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1. [DNVF Memorandum Health Services Research in Oncology].

Author

Kowalski C, Albert US, Baumann W, Carl EG, Ernstmann N, Hermes-Moll K, Fallenberg EM, Feick G, Feiten S, Härter M, Heidt V, Heuser C, Hübner J, Joos S, Katalinic A, Kempkens Ö, Kerek-Bodden H, Klinkhammer-Schalke M, Koller M, Langer T, Lehner B, Lux MP, Maatouk I, Pfaff H, Ratsch B, Schach S, Scholl I, Skoetz N, Voltz R, Wiskemann J, and Inwald E

Subjects
Germany, Humans, Palliative Care, Health Services Research, Medical Oncology, Medicine
Abstract

Health services research in oncology deals with all situations which cancer patients face. It looks at the different phases of care, i. e. prevention / early detection, prehabilitation, diagnostics, therapy, rehabilitation and palliative care as well as the various actors, including those affected, the carers and self-help. It deals with healthy people (e. g. in the context of prevention / early detection), patients and cancer survivors. Due to the nature of cancer and the existing care structures, there are a number of specific contents for health services research in oncology compared to general health services research while the methods remain essentially identical. This memorandum describes the subject, illustrates the care structures and identifies areas of health services research in oncology. This memorandum has been prepared by the Oncology Section of the German Network for Health Services Research and is the result of intensive discussions., Competing Interests: Dr. Christoph Kowalski ist Mitarbeiter der Deutschen Krebsgesellschaft. Alle anderen Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht., (Thieme. All rights reserved.)

Published
2020
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2. Device runtime and costs of cardiac resynchronization therapy pacemakers – a health claims data analysis

Author

Hadwiger, Moritz, Dagres, Nikolaos, Hindricks, Gerhard, L’hoest, Helmut, Marschall, Ursula, Katalinic, Alexander, and Frielitz, Fabian-Simon

Subjects
cardiac resynchronization therapy, device longevity, device runtime, battery runtime, health claims data, Medicine
Abstract

Introduction: This study investigates the runtime and costs of biventricular defibrillators (CRT-D) and biventricular pacemakers (CRT-P). Accurate estimates of cardiac resynchronization therapy (CRT) device runtime across all manufactures are rare, especially for CRT-P.Methods: Health claims data of a large nationwide German health insurance was used to analyze CRT device runtime. We defined device runtime as the time between the date of implantation and the date of generator change or removal. The median costs for implantation, change, and removal of a CRT device were calculated accordingly.Results: In total, the data set comprises 17,826 patients. A total of 4,296 complete runtimes for CRT-D devices and 429 complete runtimes for CRT-P devices were observed. Median device runtime was for CRT-D devices and 8.16 years for CRT-P devices (log-rank test p

Published
2022
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3. Are the results of questionnaires measuring non-cognitive characteristics during the selection procedure for medical school application biased by social desirability?

Author

Obst, Katrin U., Brüheim, Linda, Westermann, Jürgen, Katalinic, Alexander, and Kötter, Thomas

Subjects
Medical Education, College Admission Test, Psychometrics, Personality Inventory, Social Desirability, Special aspects of education, LC8-6691, Medicine
Abstract

Introduction: A stronger consideration of non-cognitive characteristics in Medical School application procedures is desirable. Psychometric tests could be used as an economic supplement to face-to-face interviews which are frequently conducted during university internal procedures for Medical School applications (AdH, Auswahlverfahren der Hochschulen). This study investigates whether the results of psychometric questionnaires measuring non-cognitive characteristics such as personality traits, empathy, and resilience towards stress are vulnerable to distortions of social desirability when used in the context of selection procedures at Medical Schools.Methods: This study took place during the AdH of Lübeck University in August 2015. The following questionnaires have been included: NEO-FFI, SPF, and AVEM. In a 2x1 between-subject experiment we compared the answers from an alleged application condition and a control condition. In the alleged application condition we told applicants that these questionnaires were part of the application procedure. In the control condition applicants were informed about the study prior to completing the questionnaires.Results: All included questionnaires showed differences which can be regarded as social-desirability effects. These differences did not affect the entire scales but, rather, single subscales.Conclusion: These results challenge the informative value of these questionnaires when used for Medical School application procedures. Future studies may investigate the extent to which the differences influence the actual selection of applicants and what implications can be drawn from them for the use of psychometric questionnaires as part of study-place allocation procedures at Medical Schools.

Published
2016
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4. Qualitative Erhebung mit Patient*innen und Angehörigen zu Einstellungen und Bewertungen einer Intervention zur Förderung der Teilnahme an einer Früherkennungskoloskopie unter erstgradig Verwandten von Darmkrebserkrankten (SAPHIR-Studie)

Author

Noftz, Maria Raili, Brunßen, Alicia, Bussmann, Marie Luise, Frielitz, Fabian Simon, Waldmann, Annika, and Katalinic, Alexander

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund/Fragestellung: In der 2014-2016 durchgeführten SAPHIR-Studie konnte in einem RCT gezeigt werden, dass eine zielgerichtete Kommunikator*in-Schulung zum Thema familiäres Darmkrebsrisiko und Vorsorgekoloskopie bei Patient*innen mit neu diagnostiziertem Kolonkarzinom,[zum vollständigen Text gelangen Sie über die oben angegebene URL], Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin

Published
2020

5. Survival of malignant mesothelioma and other rare thoracic cancers in Germany and the United States: A population-based study

Author

Sirri, Eunice, Kieschke, Joachim, Vohmann, Claudia, Katalinic, Alexander, Nennecke, Alice, Ressing, Meike, Eberle, Andrea, Holleczek, Bernd, Jansen, Lina, Brenner, Hermann, and The GEKID Cancer Survival Working Group

Subjects
Oncology, Male, Cancer Research, 0302 clinical medicine, Risk Factors, Germany, Epidemiology, Mass Screening, Mesothelioma, Neoplasms, Glandular and Epithelial, Registries, Child, Relative survival, Incidence (epidemiology), Incidence, Age Factors, Middle Aged, Prognosis, 030220 oncology & carcinogenesis, Child, Preschool, Epidemiological Monitoring, Malignant Epithelial Tumors, Female, End results, Adult, medicine.medical_specialty, Adolescent, 03 medical and health sciences, Young Adult, Sex Factors, Internal medicine, medicine, Humans, United States, Survival, Rare thoracic cancers, Mortality, Aged, Health Services Needs and Demand, business.industry, Mesothelioma, Malignant, Infant, Newborn, Cancer, Infant, Thymus Neoplasms, medicine.disease, Survival Analysis, Population based study, Tracheal Neoplasms, business
Abstract

Evidence on survival of malignant mesothelioma (MM) and other rare thoracic cancers is limited due to the rarity of these cancer sites. Here, we provide a comprehensive overview of MM incidence and survival after MM and other rare thoracic cancers in Germany and the United States (US). Incidence was estimated from a German National Cancer Database and from the Surveillance, Epidemiology and End Results (SEER) 18 database for 2000–2014. Patients diagnosed in 1997–2013 with malignant epithelial tumors of the trachea (Etra), epithelial tumors of the thymus (Ethy) and MM were extracted from a German cancer survival database and from the SEER 13 database. Period analysis was employed to compute 5‐year relative survival (RS). During 2000–2014, an annual average of 0.9 and 0.6 MM cases per 100,000 person‐years was diagnosed in Germany and the US. Rates decreased in Germany and in the US. Patients with Ethy had highest 5‐year RS with US patients surviving longer (69.1% compared to 63.7%, p = 0.02). Survival after Etra was comparable in both countries (Germany 33.6%, US 34.4%, p = 0.07). Survival in MM patients was poor overall (Germany 11.8%, US 12.1%, p

Published
2019

6. Divergent Patterns and Trends in Breast Cancer Incidence, Mortality and Survival Among Older Women in Germany and the United States

Author

Jansen, Lina, Holleczek, Bernd, Kraywinkel, Klaus, Weberpals, Janick, Schröder, Chloé Charlotte, Eberle, Andrea, Emrich, Katharina, Kajüter, Hiltraud, Katalinic, Alexander, Kieschke, Joachim, Nennecke, Alice, Sirri, Eunice, Heil, Joerg, Schneeweiss, Andreas, Brenner, Hermann, and The GEKID Cancer Survival Working Group

Subjects
trends, Cancer Research, United States, Survival, Trends, Mortality, Incidence, Breast cancer, Germany, Breast cancer mortality, Population, survival, lcsh:RC254-282, Article, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Medicine, 030212 general & internal medicine, Stage (cooking), Mortality trends, education, education.field_of_study, Relative survival, business.industry, Incidence (epidemiology), lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, mortality, Cancer registry, Oncology, 030220 oncology & carcinogenesis, incidence, business, Demography
Abstract

Background: Breast cancer treatment has changed tremendously over the last decades. In addition, the use of mammography screening for early detection has increased strongly. To evaluate the impact of these developments, long-term trends in incidence, mortality, stage distribution and survival were investigated for Germany and the United States (US). Methods: Using population-based cancer registry data, long-term incidence and mortality trends (1975&ndash, 2015), shifts in stage distributions (1998&ndash, 2015), and trends in five-year relative survival (1979&ndash, 2015) were estimated. Additionally, trends in five-year relative survival after standardization for stage were explored (2004&ndash, 2015). Results: Age-standardized breast cancer incidence rates were much higher in the US than in Germany in all periods, whereas age-standardized mortality began to lower in the US from the 1990s on. The largest and increasing differences were observed for patients aged 70+ years with a 19% lower incidence but 45% higher mortality in Germany in 2015. For this age group, large differences in stage distributions were observed, with 29% (Germany) compared to 15% (US) stage III and IV patients. Age-standardized five-year relative survival increased strongly between 1979&ndash, 1983 and 2013&ndash, 2015 in Germany (+17% units) and the US (+19% units) but was 9% units lower in German patients aged 70+ years in 2013&ndash, 2015. This difference was entirely explained by differences in stage distributions. Conclusions: Overall, our results are in line with a later uptake and less extensive utilization of mammography screening in Germany. Further studies and efforts are highly needed to further explore and overcome the increased breast cancer mortality among elderly women in Germany.

Published
2020

7. TaBeL: gebrauchstaugliche Patient-Reported Outcomes für Patienten und Patientinnen mit Kopf-Hals-Tumoren

Author

Scherf, Jannick, Herczeg, Michael, Mentler, Tilo, Quandt, Joachim, Peters, Elke, Katalinic, Alexander, and Wollenberg, Barbara

Subjects
Epidemiologie, Medizinische Dokumentation, ddc: 610, Medizinische Informatik, 610 Medical sciences, Medicine
Abstract

Einleitung: Im Kontext der ambulanten Routineversorgung von Kopf-Hals-Tumor-Patienten ist die Kommunikation zwischen Patienten und behandelnden Ärzten eine zentrale Herausforderung. In den regelmäßig, üblicherweise vierteljährlich stattfindenden Nachsorgesprächen zwischen[zum vollständigen Text gelangen Sie über die oben angegebene URL], 63. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)

Published
2018
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8. Survival of patients with lymphoplasmacytic lymphoma and solitary plasmacytoma in Germany and the United States of America in the early 21st century

Author

Weberpals, Janick, Pulte, Dianne, Jansen, Lina, Luttmann, Sabine, Holleczek, Bernd, Nennecke, Alice, Ressing, Meike, Katalinic, Alexander, Merz, Maximilian, Brenner, Hermann, and GEKID Cancer Survival Working Group

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Adolescent, Population, Improved survival, Lymphoplasmacytic Lymphoma, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Germany, medicine, Humans, Registries, education, Online Only Articles, Multiple myeloma, Aged, education.field_of_study, business.industry, Hematology, Middle Aged, medicine.disease, United States, Survival Rate, 030220 oncology & carcinogenesis, Population Surveillance, Female, Waldenstrom Macroglobulinemia, business, Solitary plasmacytoma, 030215 immunology, Plasmacytoma, SEER Program
Abstract

Population-level survival has increased for a number of hematologic malignancies.[1][1]–[3][2] Multiple myeloma, in particular, has seen improved survival both in clinical trials[4][3]–[8][4] and on the population level.[3][2],[9][5]–[11][6] However, it is not known whether the changes in

Published
2017

9. Erstellung einer Datenbasis zur Analyse von Darmkrebsinzidenz und -mortalität und der Teilnahme an Darmkrebsfrüherkennung auf Ebene der Landkreise in Deutschland

Author

Lewin, Philip, Hübner, Joachim, Pritzkuleit, Ron, Eisemann, Nora, and Katalinic, Alexander

Subjects
ddc: 610, Big Data techniques for clinical registries, 610 Medical sciences, Medicine, Cancer
Abstract

Hintergrund: In den letzten Jahren ist für Darmkrebs ein Rückgang der altersstandardisierten Inzidenz und Mortalität bei beiden Geschlechtern zu beobachten [ref:1]. Ein Zusammenhang mit der Einführung der Früherkennungskoloskopie wird diskutiert. Prinzipiell könnten[zum vollständigen Text gelangen Sie über die oben angegebene URL], HEC 2016: Health – Exploring Complexity; Joint Conference of GMDS, DGEpi, IEA-EEF, EFMI

Published
2016

10. Einschränkungen der Teilhabe - Normdaten für den Index zur Messung von Einschränkungen der Teilhabe (IMET) auf der Basis eines Bevölkerungssurveys

Author

Deck, Ruth, Walther, Anna Lena, Staupendahl, Alexandra, and Katalinic, Alexander

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Die medizinische Rehabilitation ist geprägt vom bio-psycho-sozialen Denkmodell der Internationalen Klassifikation der Funktionsfähigkeit, Behinderung und Gesundheit (ICF). Seit der Einführung des SGB IX im Jahr 2001 ist die soziale Teilhabe ein zentrales Ziel rehabilitativer[zum vollständigen Text gelangen Sie über die oben angegebene URL], 14. Deutscher Kongress für Versorgungsforschung

Published
2015
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11. Steigt die Krankheitslast durch den nichtmelanozytären Hautkrebs? - Inzidenztrends im Zeitraum 1998 bis 2010

Author

Eisemann, Nora, Rudolph, Christiane, and Katalinic, Alexander

Subjects
Inzidenz, ddc: 610, 610 Medical sciences, Medicine, Nichtmelanozytärer Hautkrebs, Epidemiologisches Krebsregister
Abstract

Einleitung: Der nichtmelanozytäre Hautkrebs („weißer Hautkrebs“, NMSC) ist die häufigste Krebserkrankung in Deutschland. Aufgrund des meist günstigen Verlaufes findet der NMSC in der Epidemiologie oft weniger Beachtung als andere Krebserkrankungen. In der regulären[zum vollständigen Text gelangen Sie über die oben angegebene URL], GMDS 2015; 60. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)

Published
2015

12. Kleinräumiger Atlas der Krebsepidemiologie in Schleswig-Holstein

Author

Eisemann, Nora, Pritzkuleit, Ron, and Katalinic, Alexander

Subjects
Geographie, ddc: 610, Krebsepidemiologie, 610 Medical sciences, Medicine
Abstract

Einleitung: Bevölkerungsbezogene Krebsregister erheben flächendeckend Daten zur Krebsepidemiologie und sind dadurch für räumliche Auswertungen prädestiniert. Für kleinräumige Analysen müssen die Daten sowohl in ausreichend kleinen administrative Gebiete gegeben[zum vollständigen Text gelangen Sie über die oben angegebene URL], GMDS 2015; 60. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)

Published
2015

13. Ein systematisches Review zum Einfluss von Hautkrebsscreening und Kampagnen der Sekundärprävention auf Inzidenz und Mortalität

Author

Brunßen, Alicia, Waldmann, Annika, Eisemann, Nora, and Katalinic, Alexander

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Zielsetzung: Die deutsche S3-Leitlinie „Prävention von Hautkrebs“ spricht auf Basis einer Primärstudie die Empfehlung aus, dass zur Hautkrebsprävention ein Hautkrebsscreening (HKS) angeboten werden sollte. Sie enthält jedoch ein Sondervotum der Deutschen Gesellschaft[for full text, please go to the a.m. URL], EbM zwischen Best Practice und inflationärem Gebrauch; 16. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin

Published
2015
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14. Einfluss von Maßnahmen zur Geschwindigkeitsmessung auf die subjektive Verkehrslärmbelastung von Anwohnern lärmbelasteter Straßen in Lübeck

Author

Schnoor, Maike, Waldmann, Annika, and Katalinic, Alexander

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung und Fragestellung: Weniger bzw. verstetigter Autoverkehr mit geringerer Durchschnittsgeschwindigkeit in Städten dient nicht nur der Verbesserung des Lärm- und Klimaschutzes, sondern auch der Förderung von Gesundheit und Lebensqualität. Da das subjektive Lärmempfinden[for full text, please go to the a.m. URL], GMDS 2013; 58. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)

Published
2013

15. Trends der Stadien-spezifischen Darmkrebsinzidenz in Deutschland nach Einführung der Koloskopie als Früherkennungsmaßnahme

Author

Schnoor, Maike, Eisemann, Nora, and Katalinic, Alexander

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung und Fragestellung: Seit 2002 haben in Deutschland alle Versicherten ab einem Alter von 55 Jahren gesetzlichen Anspruch auf eine Koloskopie zur Darmkrebsfrüherkennung. Ziel des flächendeckenden Screenings ist es, durch die Entfernung von Adenomen und Polypen im Darm die Zahl der [for full text, please go to the a.m. URL], GMDS 2013; 58. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)

Published
2013

16. GMDS meets Neues Krebsregistergesetz

Author

Katalinic, Alexander and Hofstädter, Ferdinand

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Am 9. April 2013 ist das neue KFRG, dass Krebsfrüherkennungs- und -registergesetz in Kraft getreten. Alle Bundesländer müssen nun neben den epidemiologischen auch flächendeckende klinische Krebsregister einrichten. Ein wesentliches Ziel der klinischen Registrierung ist die Verbesserung[for full text, please go to the a.m. URL], GMDS 2013; 58. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)

Published
2013
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17. Cluster - Möglichkeiten und Grenzen von Krebsregisterdaten bei der Beurteilung von Krebsclustern - Das Beispiel Wewelsfleth

Author

Pritzkuleit, Ron and Katalinic, Alexander

Subjects
Krebs, ddc: 610, Risikokommunikation, 610 Medical sciences, Medicine, Häufung
Abstract

Hintergrund: Eine wesentliche Aufgabe epidemiologischer Krebsregister ist die Beurteilung verdächtiger Häufungen von Krebsfällen. Am Beispiel der Gemeinde Wewelsfleth (Schleswig-Holstein), der Nachbargemeinde eines Atomkraftwerkes (Brokdorf), soll gezeigt werden, welche Analysen standardmäßig[for full text, please go to the a.m. URL], Mainz//2011; 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi)

Published
2011

18. Unterschiedliche Aspekte der selbstberichteten gesundheitsbezogenen Lebensqualität von 450 Melanompatienten aus Schleswig-Holstein

Author

Waldmann, Annika, Nolte, Sandra, Pritzkuleit, Ron, Breitbart, Eckhard W., and Katalinic, Alexander

Subjects
ddc: 610, populationsbezogene Studie, Hautkrebs, 610 Medical sciences, Medicine, Melanom, Lebensqualität
Abstract

Einleitung/Hintergrund: In den letzten Jahren haben patientenzentrierte Endpunkte in der Bewertung von medizinischen Maßnahmen an Bedeutung gewonnen – so auch die selbstberichtete, gesundheitsbezogene Lebensqualität. Während die Datenlage für Brust-, Prostata- oder auch[for full text, please go to the a.m. URL], Mainz//2011; 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi)

Published
2011

19. Long-term prognosis of cancer patients in Germany:Up-to-date national estimates, regional variation and international comparisons

Author

Brenner, Hermann and Katalinic, Alexander

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Background: Monitoring cancer survival by population-based cancer registries is a prerequisite for evaluating overall quality of cancer care. In the past, population-based cancer survival data from Germany were often restricted to Saarland (about 1 of >80 million inhabitants). Methods: We set[for full text, please go to the a.m. URL], Mainz//2011; 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi)

Published
2011

20. Cancer and area-based social deprivation

Author

Pritzkuleit, Ron, Mielck, Andreas, Meyer, Martin, and Katalinic, Alexander

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Background: The CANADA project (CANcer And Deprivation Analyses) had the aim to develop an index or to choose relevant indicators to measure the social deprivation on an area level. Two reasons for such an index are given - first, to do ecological analyses and second to estimate the social deprivation[for full text, please go to the a.m. URL], Mainz//2011; 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi)

Published
2011
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21. Tumorstadienverschiebung des malignen Melanoms nach Hautkrebsscreening

Author

Eisemann, Nora, Waldmann, Annika, and Katalinic, Alexander

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Das Hautkrebsscreening als Leistung der gesetzlichen Krankenkassen wurde 2008 flächendeckend in Deutschland eingeführt, nachdem in Schleswig-Holstein 2003 bis 2004 ein Pilot-Projekt durchgeführt wurde. Bislang gibt es keine verlässlichen Daten zu den Effekten eines Hautkrebsscreenings[for full text, please go to the a.m. URL], Mainz//2011; 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi)

Published
2011

22. A Novel Approach to Estimate the Population-based Incidence of Testicular Cancer in Germany

Author

Stang, Andreas, Katalinic, Alexander, and Stabenow, Roland

Subjects
endocrine system, hospitalization data, endocrine system diseases, ddc: 610, urogenital system, incidence, 610 Medical sciences, Medicine, urologic and male genital diseases, testicular cancer
Abstract

Introduction: Nationwide DRG hospitalization data may provide a data source for the estimation of testicular cancer incidence. As orchiectomy for testicular cancer is the standard therapy undertaken in hospitals, a hospitalization with a diagnosis of testicular cancer and a treatment by orchiectomy [for full text, please go to the a.m. URL], 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds)

Published
2009

23. Survival of patients with gastric lymphoma in Germany and in the United States.

Author

Castro, Felipe A, Jansen, Lina, Krilaviciute, Agne, Katalinic, Alexander, Pulte, Dianne, Sirri, Eunice, Ressing, Meike, Holleczek, Bernd, Luttmann, Sabine, and Brenner, Hermann

Subjects
GASTRIC diseases, LYMPHOMAS, B cell lymphoma, MUCOSA-associated lymphoid tissue lymphoma, CANCER, MEDICINE, PATIENTS, THERAPEUTICS
Abstract

Background and Aim This study aims to examine survival for gastric lymphomas and its main subtypes, mucosa-associated lymphoid tissue lymphoma ( MALT), and diffuse large B-cell lymphoma ( DLBCL), in Germany and in the United States. Methods Data for patients diagnosed in 1997-2010 were used from 10 population-based German cancer registries and compared to the data from the US Surveillance, Epidemiology and End Results ( SEER) 13 registries database. Patients age 15-74 diagnosed with gastric lymphomas were included in the analysis. Period analysis and modeled period analysis were used to estimate 5-year and 10-year relative survival ( RS) in 2002-2010 and survival trends from 2002-2004 to 2008-2010. Results Overall, the database included 1534 and 2688 patients diagnosed with gastric lymphoma in 1997-2010 in Germany and in the United States, respectively. Survival was substantially higher for MALT (5-year and 10-year RS: 89.0% and 80.9% in Germany, 93.8% and 86.8% in the United States) than for DLBCL (67.5% and 59.2% in Germany, and 65.3% and 54.7% in the United States) in 2002-2010. Survival was slightly higher among female patients and decreased by age for gastric lymphomas combined and its main subtypes. A slight, nonsignificant, increase in the 5-year RS for gastric lymphomas combined was observed in Germany and the United States, with increases in 5-year RS between 2002-2004 and 2008-2010 from 77.1% to 81.0% and from 77.3% to 82.0%, respectively. Five-year RS of MALT exceeded 90% in 2008-2010 in both countries. Conclusions Five-year RS of MALT meanwhile exceeds 90% in both Germany and the United States, but DLBCL has remained below 70% in both countries. [ABSTRACT FROM AUTHOR]

Published
2015
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24. Survival of Adults with Acute Lymphoblastic Leukemia in Germany and the United States.

Author

Pulte, Dianne, Jansen, Lina, Gondos, Adam, Katalinic, Alexander, Barnes, Benjamin, Ressing, Meike, Holleczek, Bernd, Eberle, Andrea, and Brenner, Hermann

Subjects
LYMPHOBLASTIC leukemia, RARE diseases, DISEASES in young adults, MEDICAL protocols, BIOSURVEILLANCE, CLINICAL trials, PATIENTS
Abstract

Background: Adulthood acute lymphoblastic leukemia (ALL) is a rare disease. In contrast to childhood ALL, survival for adults with ALL is poor. Recently, new protocols, including use of pediatric protocols in young adults, have improved survival in clinical trials. Here, we examine population level survival in Germany and the United States (US) to gain insight into the extent to which changes in clinical trials have translated into better survival on the population level. Methods: Data were extracted from the Surveillance, Epidemiology, and End Results database in the US and 11 cancer registries in Germany. Patients age 15–69 diagnosed with ALL were included. Period analysis was used to estimate 5-year relative survival (RS). Results: Overall 5-year RS was estimated at 43.4% for Germany and 35.5% for the US (p = 0.004), with a decrease in survival with increasing age. Survival was higher in Germany than the US for men (43.6% versus 37.7%, p = 0.002) but not for women (42.4% versus 40.3%, p>0.1). Five-year RS estimates increased in Germany and the US between 2002 and 2006 by 11.8 and 7.3 percent units, respectively (p = 0.02 and 0.04, respectively). Conclusions: Survival for adults with ALL continues to be low compared with that for children, but a substantial increase in 5-year survival estimates was seen from 2002 to 2006 in both Germany and the US. The reasons for the survival differences between both countries require clarification. [ABSTRACT FROM AUTHOR]

Published
2014
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25. Sex Differences in Colorectal Cancer Survival: Population-Based Analysis of 164,996 Colorectal Cancer Patients in Germany.

Author

Majek, Ondrej, Gondos, Adam, Jansen, Lina, Emrich, Katharina, Holleczek, Bernd, Katalinic, Alexander, Nennecke, Alice, Eberle, Andrea, and Brenner, Hermann

Subjects
SEX differences (Biology), COLON cancer patients, COLON cancer risk factors, COLON cancer prognosis, GASTROINTESTINAL cancer, SEX hormones
Abstract

Risk of colorectal cancer (CRC) is considerably higher in men compared to women; however, there is inconclusive evidence of sex differences in CRC prognosis. We aimed to assess and explain sex differences in 5-year relative survival using standard and model-based period analysis among 164,996 patients diagnosed with CRC from 1997 to 2006 and reported to 11 German cancer registries covering a population of 33 million inhabitants. Age-adjusted 5-year relative survival was higher in women (64.5% vs. 61.9%, P<0.0001). A substantial survival advantage of women was confirmed in multivariate analysis after adjusting for CRC stage and subsite in subjects under 65 years of age (relative excess risk, RER 0.86, 95% CI 0.82–0.90), but not in older subjects (RER 1.01, 95% CI 0.98–1.04); this pattern was similar in the 1st and in the 2nd to 5th year after diagnosis. The survival advantage of women varied by CRC stage and age and was most pronounced for localized disease (RERs 0.59–0.88 in various age subgroups) and in patients under 45 years of age (RERs 0.59, 0.72 and 0.76 in patients with localized, regional or advanced disease, respectively). On the contrary, sex differences in survival did not vary by location of CRC. In conclusion, our large population-based study confirmed a survival advantage of female compared to male CRC patients, most notably in young and middle aged patients and patients with localized disease. The effect of sex hormones, either endogenous or through hormonal replacement therapy, might be the most plausible explanation for the observed patterns. [ABSTRACT FROM AUTHOR]

Published
2013
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