1. Vitamin E Intake Is Associated with Lower Brain Volume in Haptoglobin 1-1 Elderly with Type 2 Diabetes
- Author
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Laili Soleimani, Jeremy M. Silverman, Andrew P. Levy, Mary Mamistalov, Ramit Ravona-Springer, Derek LeRoith, Rachel Preiss, Barbara B. Bendlin, Danit-Rivka Shahar, Anthony Heymann, Abigail Livny, Yuval Berman, Erin Moshier, Michal Schnaider Beeri, and Galia Tsarfaty
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Middle temporal gyrus ,medicine.medical_treatment ,Inferior frontal gyrus ,Type 2 diabetes ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Internal medicine ,Genotype ,medicine ,Humans ,Vitamin E ,Longitudinal Studies ,Aged ,Haptoglobins ,biology ,business.industry ,General Neuroscience ,Haptoglobin ,Brain ,Organ Size ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,Endocrinology ,Diabetes Mellitus, Type 2 ,Brain size ,biology.protein ,Female ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery - Abstract
Backgrounds The efficacy of vitamin E in prevention of diabetes-related complications differs by Haptoglobin (Hp) genotype. Objective To examine the role of Hp genotype in the relationship of vitamin E intake with brain volume in cognitively normal elderly patients with type 2 diabetes. Methods Brain volumes for the superior, middle, and inferior frontal gyri and for the middle temporal gyrus were generated from structural T1 MRI in 181 study participants (Hp 1-1: n = 24, Hp 2-1: n = 77, Hp 2-2: n = 80). Daily vitamin E intake was assessed using the Food Frequency Questionnaire. Analyses of covariance, controlling for demographic and cardiovascular variables was used to evaluate whether the association of daily vitamin E intake with brain volume was modified by Hp genotype. Results Average age was 70.8 (SD = 4.2) with 40% females, and mean Mini-Mental State Examination score of 28.17 (SD = 1.90). A significant interaction was found between vitamin E intake and Hp genotype in inferior frontal gyrus' volume; p = 0.0108. For every 1 microgram increase in vitamin E intake, the volume of the inferior frontal gyrus decreased by 0.955% for Hp 1-1 (p = 0.0348), increased by 0.429% for Hp 2-1 (p = 0.0457), and by 0.077% for Hp 2-2 (p = 0.6318). There were no significant interactions between vitamin E intake and Hp genotype for the middle (p = 0.6011) and superior (p = 0.2025) frontal gyri or for the middle temporal gyrus (p = 0.503). Conclusions The effect of dietary vitamin E on the brain may differ by Hp genotype. Studies examining the impact of vitamin E on brain-related outcomes should consider Hp genotype.
- Published
- 2020