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International audience; BACKGROUND: Atopic dermatitis (AD) and psoriasis are chronic inflammatory cutaneous disorders for which the gold standard treatment is topical corticosteroids. Although fears about topical corticosteroids are known to be a primary cause of poor therapeutic adherence in AD, this has not been evaluated in psoriasis. TOPICOP is a helpful and easy-to-use tool for the evaluation of topical corticosteroid concerns (TCC). It may help clinicians improve adherence to treatment and correct misconceptions. OBJECTIVE: We aimed to compare the TCC of parents of children with psoriasis or AD using the TOPICOP scale and a visual analog scale (VAS). METHODS: We performed a cross-sectional multicenter study in nine French hospitals from 1 October 2015 to 31 May 2016. The~TOPICOP scale was developed for patients with AD and comprises 12 questions to assess patients' worries and beliefs about topical corticosteroids, with a maximum score of 36.~We used a standardized questionnaire to collect epidemiologic and medical data, and the parents completed the TOPICOP scale and VAS (score 0-10). RESULTS: A total of 122 children were enrolled (61 patients in each group). The mean Physician Global Assessment was 2.1 in the psoriasis group, and the mean SCORing AD index was 33.3 in the AD group. The TOPICOP score was 16.0 in the psoriasis group and 18.8 in the AD group (p~=~0.10). The VAS score was 5.6 and 5.1 in the psoriasis and AD groups, respectively (p~=~0.18). The mean TOPICOP score was higher if the mother answered (p~

Background Blueberry Muffin Baby is a rare neonatal cutaneous syndrome for purpuric lesions reflective of extramedullary hematopoiesis. Many causes are known, examples are congenital infections, malignancy and hematologic disorders. Langerhans' cell histiocytosis is a clonal proliferation of dendritic histiocytes. This has very rarely been associated with a Blueberry Muffin Baby presentation. Case report We report the case of a newborn presenting with Blueberry Muffin Baby syndrome related to congenital Langherans' cell histiocytosis. At birth, he had multiple purpuric lesions on the trunk, limbs and face. Skin biopsy showed a dermal proliferation of histiocytes staining positive for S100 and CD1a. Chest and bone radiographs, and abdominal ultrasound were normal. Skin lesions have resolved in 8 weeks, the patient is in complete remission at 18 months of follow-up. Discussion A Blueberry Muffin Baby syndrome may reveal neonatal Langerhans' histiocytosis.

Resume Nous rapportons le cas d’un enfant de 4 ans et 10 mois atteint de fievre mediterraneenne familiale (FMF) revelee par une atteinte cutanee polymorphe. La FMF est une maladie autosomique recessive caracterisee par des acces febriles recurrents associes a des epanchements sereux tels que peritonite, pleuresie et arthrite. L’atteinte cutanee est rare. Dans notre observation, l’enfant avait presente successivement une eruption pseudo-erysipeloide, des œdemes des mains et des pieds puis des lesions purpuriques. Devant ces lesions, plusieurs diagnostics avaient ete evoques : dermohypodermite infectieuse, maladie de Kawasaki, purpura rhumatoide, FMF. Seul ce dernier diagnostic avait ete retenu puis confirme par l’analyse genetique ayant mis en evidence une mutation M694V a l’etat homozygote. L’eruption pseudo-erysipeloide est l’atteinte cutanee la plus frequente d’apres la litterature et la seule a etre en lien avec le genotype M694V homozygote. L’originalite de notre observation repose sur le polymorphisme des lesions cutanees qui ont revele la maladie.

________________________________________ Resume Introduction Nous rapportons le cas d'une fille de six ans qui a developpe un eczema aigu du visage secondaire a l'application d'un cosmetique emollient contenant du methoxy PEG 22 dodecyl glycol. Observation Une petite fille de six ans etait amenee en urgence pour un eczema aigu du visage secondaire a une application, la veille, de creme " Mustela Cold Cream Nutriprotecteur® ". Afin de confirmer son imputabilite, des patch-tests ont ete realises avec la batterie standard europeenne et avec la creme de la patiente : le seul test positif a ++ correspondait au Mustela Cold Cream®. Des patch-tests complementaires ont alors ete effectues avec les composants de la creme : le seul test positif a ++ correspondait au methoxy PEG 22 dodecyl glycol. Discussion Le methoxy PEG 22 dodecyl glycol appartient a la famille des copolymeres, molecules utilisees dans les cosmetiques afin de stabiliser les emulsions et d'augmenter la viscosite. Une vingtaine de cosmetiques sur le marche comportent ce copolymere, dont la majorite sont destines aux enfants. L'allergie de contact au methoxy PEG 22 dodecyl glycol reste rare mais doit etre connue en raison de l'importance des reactions cliniques et d'une cible essentiellement pediatrique. ________________________________________ Summary Background We report the case of a girl presenting acute allergic contact dermatitis due to methoxy PEG 22 dodecyl glycol contained in Mustela Cold Cream Nutriprotecteur®. Patients and methods A 6-year-old girl was referred with acute eczema of the face occurring within 12 h of applying a new moisturizing cream, Mustela Cold Cream Nutriprotecteur®. Patch tests were performed on the upper back using the Finn Chamber technique with the European standard series and the patient's own cream. Readings were performed after 2 days and the sole positive ++ reaction was associated with Mustela Cold Cream®. Additional patch testing was carried out with the ingredients of the cream, with the sole positive ++ reaction again being to methoxy PEG 22 dodecyl glycol copolymer. The other ingredients were negative. Discussion Methoxy PEG 22 dodecyl glycol is a copolymer used in cosmetics as an emulsion stabilizer and viscosity-increasing agent. It is found in 20 cosmetics currently on the market, most of which are prescribed for children. Conclusion Although it is rare, doctors must be aware of allergic contact dermatitis due to methoxy PEG 22 dodecyl glycol because of the extent of clinical reactions and because it chiefly affects the paediatric population. Choose an option to locate/access this article: " " Mots cles " Eczema de contact; " Copolymeres; " Cosmetiques; " Methoxy PEG 22 dodecyl glycol Keywords " Allergic contact dermatitis; " Copolymers; " Cosmetics; " Methoxy PEG 22 dodecyl glycol ________________________________________ Figures and tables from this article: Figure 1. Eczema de contact aigu du visage. Figure options Figure 2. Patch-tests a 48 heures positif a ++ pour la creme de la patiente, negatifs pour la batterie standard europeenne. Figure options Figure 3. Patch test complementaires a 48 heures positif a ++ pour le methoxy PEG 22 dodecyl glycol.