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Your search keyword '"Luigi Polidori"' showing total 3 results
Start Over Author "Luigi Polidori" Topic medicine
3 results on '"Luigi Polidori"'

1. Comprehensive Observational and Longitudinal study on the Outbreak of Stroke-related Spasticity focusing on the Early Onset management with Botulinum NeuroToxin (COLOSSEO-BoNT): protocol for a real-world prospective observational study on upper limb spasticity

Author

Vincenzo Di Lazzaro, Claudio Gasperini, Diego Centonze, Danilo Toni, Deepak Gupta, Irene Aprile, Fabio Pilato, Marina Diomedi, Massimo Marano, Giovanni Frisullo, Marco Andrighetti, Maria Concetta Altavista, Luigi Polidori, Antonio Suppa, Maria Giuseppina Palmieri, Emanuela Cecconi, Roberta Bovenzi, Vittorio Riso, Alexia Anzini, Marianna Brienza, Sabrina Anticoli, Domenica Crupi, Morena Giovannelli, Andrea Massimiani, Steno Rinalduzzi, Emanuele Morena, Maria Carlotta Massara, Letizia Cupini, Federica Bressi, Loredana Maggi, Donato Sauchelli, Ennio Iezzi, Alessandro Magliozzi, Stefano Toro, Gaia Anzini, Claudia Celletti, Paolo Amisano, Marco Falletti, Pierandrea Rizzo, Grazia Libutti, Marilena Mangiardi, Francesca Romana Pezzella, Silvia La Cesa, Marina Cao, Francesco Asci, Serena Capobianco, Luisella D’Angeli, and Caterina Galluccio

Subjects
Medicine
Abstract

Introduction Poststroke spasticity (PSS) affects up to 40% of patients who had a stroke. Botulinum neurotoxin type A (BoNT-A) has been shown to improve spasticity, but the optimal timing of its application remains unclear. While several predictors of upper limb PSS are known, their utility in clinical practice in relation to BoNT-A treatment has yet to be fully elucidated. The COLOSSEO-BoNT study aims to investigate predictors of PSS and the effects of BoNT-A timing on spasticity-related metrics in a real-world setting.Methods and analysis The recruitment will involve approximately 960 patients who have recently experienced an ischaemic stroke (within 10 days, V0) and will follow them up for 24 months. Parameters will be gathered at specific intervals: (V1) 4, (V2) 8, (V3) 12, (V4) 18 months and (V5) 24 months following enrolment. Patients will be monitored throughout their rehabilitation and outpatient clinic journeys and will be compared based on their BoNT-A treatment status—distinguishing between patients receiving treatment at different timings and those who undergo rehabilitation without treatment. Potential predictors will encompass the Fugl-Meyer assessment, the National Institute of Health Stroke Scale (NIHSS), stroke radiological characteristics, performance status, therapies and access to patient care pathways. Outcomes will evaluate muscle stiffness using the modified Ashworth scale and passive range of motion, along with measures of quality of life, pain, and functionality.Ethics and dissemination This study underwent review and approval by the Ethics Committee of the Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. Regardless of the outcome, the findings will be disseminated through publication in peer-reviewed journals and presentations at national and international conferences.Trial registration number NCT05379413.

Published
2024
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2. Spinal and cortical inhibition in huntington's chorea

Author

Alberto Priori, Luigi Polidori, Mario Manfredi, Alfredo Berardelli, and S. Rona

Subjects
Adult, Male, medicine.medical_treatment, Models, Neurological, Presynaptic Terminals, Inhibitory postsynaptic potential, H-Reflex, Magnetics, Neural Pathways, medicine, Humans, Aged, Electromyography, Motor Cortex, Reciprocal inhibition, Neural Inhibition, Middle Aged, Spinal cord, Electric Stimulation, Transcranial magnetic stimulation, Huntington Disease, medicine.anatomical_structure, Spinal Cord, Neurology, Cerebral cortex, Case-Control Studies, Female, Neurology (clinical), medicine.symptom, H-reflex, Hyperkinesia, Psychology, Neuroscience, Motor cortex
Abstract

In this article we studied spinal and cortical inhibitory mechanisms in patients with Huntington's disease. To evaluate spinal cord inhibitory circuitries, we assessed reciprocal inhibition between antagonist forearm muscles and the recovery cycle of the H reflex in the flexor carpi radialis. Patients showed a significant decrease in the presynaptic phase of reciprocal inhibition reaching a minimum at the conditioning-test interval of 20 msec and an abnormal facilitation of the test H reflex at the conditioning test interval of 40 to 60 msec. Throughout its time course (10-200 msec), the H reflex recovery cycle showed a more prominent facilitation in patients than in control subjects. To assess whether the observed pathophysiological abnormalities might have arisen from an abnormal motor cortical excitability, we examined the recovery cycle of the motor potentials evoked by paired transcranial magnetic stimuli. We found that the inhibitory mechanisms controlling motor cortical excitability were normal. An interpretation of the spinal cord abnormalities is that the intrinsically normal but deafferentated motor cortex in Huntington's disease partly loses its inhibitory control, thus disinhibiting spinal cord circuitry. Our findings from paired transcranial magnetic stimulation suggest that cortical motor areas are not hyperexcitable in Huntington's disease. Hence, the postulated thalamocortical overactivity in experimental models of Huntington's disease needs to be reappraised.

Published
2000
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3. Electromyographic silent period after transcranial brain stimulation in Huntington's disease

Author

Alberto Priori, Alfredo Berardelli, Maurizio Inghilleri, Luigi Polidori, and Mario Manfredi

Subjects
Adult, Male, medicine.medical_specialty, Stimulation, Electric Stimulation Therapy, Electromyography, Basal Ganglia, Huntington's disease, Internal medicine, Basal ganglia, Neural Pathways, medicine, Humans, Evoked Potentials, Aged, medicine.diagnostic_test, Muscles, Motor Cortex, Chorea, Neural Inhibition, Middle Aged, medicine.disease, medicine.anatomical_structure, Huntington Disease, Neurology, Brain stimulation, Cardiology, Silent period, Female, Neurology (clinical), medicine.symptom, Psychology, Neuroscience, Motor cortex, Muscle Contraction
Abstract

The silent period evoked by transcranial (TCS) and nerve stimulation was studied in the hand muscles in 13 patients with Huntington's disease and in 11 normal subjects. The duration of the silent period after TCS was longer in patients and correlated significantly with the severity of chorea; in contrast, the duration of the silent period after nerve stimulation was similar in patients and controls. The prolongation of the cortical silent period suggests that the duration of the silent period is a functional correlate reflecting basal ganglia influence over the motor cortex.

Published
1994

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