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3. Intracellular retention of the extracellular domain of the (pro)renin receptor in mammalian cells

Author

Akio Ebihara, Masako Noda, Misa Nishimura, Tsutomu Nakagawa, Masaru Hattori, Hideyuki Iwata, Chiharu Suzuki-Nakagawa, and Fumiaki Suzuki

Subjects
Cell, Immunocytochemistry, Intracellular Space, Receptors, Cell Surface, Biology, Applied Microbiology and Biotechnology, Biochemistry, Intracellular retention, Analytical Chemistry, Renin-Angiotensin System, chemistry.chemical_compound, Renin–angiotensin system, Chlorocebus aethiops, medicine, Extracellular, Animals, Humans, Prorenin Receptor, Receptor, Molecular Biology, Organic Chemistry, General Medicine, Glutathione, Hep G2 Cells, Protein Structure, Tertiary, Protein Transport, medicine.anatomical_structure, Membrane, chemistry, COS Cells, Extracellular Space, Biotechnology
Abstract

As a component of the renin-angiotensin system, the (pro)renin receptor [(P)RR] activates prorenin along with intracellular signaling pathways. In this study, the glutathione S-transferase-fused extracellular domain of (P)RR expressed in mammalian cells was recovered in the detergent phase in detergent-based two-phase separation experiments, and intracellular localization was observed by immunocytochemistry, suggesting retention inside the cell through stable membrane association.

Published
2014

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