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Introduction Adenocarcinoma of the rete testis is a rare malignancy with a poor prognosis. We report a case of adenocarcinoma of the rete testis with a durable response to cisplatin-based chemotherapy. Case presentation A 48-year-old man with Down syndrome (trisomy 21) presented with a 1-month history of painless swelling of the left scrotum. The physical examination revealed a left testis with a hydrocele associated with a tumor and enlarged pelvic and para-aortic lymph nodes. He underwent a radical orchiectomy. The specimen was diagnosed as adenocarcinoma of the rete testis. The patient received 7 cycles of chemotherapy (1 cycle of BEP and 6 cycles of EP) postoperatively. The metastatic lymph nodes were reduced in size for at least 12 months. Our patient with adenocarcinoma of the rete testis obtained an acceptable response to cisplatin-based chemotherapy. Conclusion We treated a patient with an adenocarcinoma of the rete testis who had an acceptable response to platinum-based chemotherapy.

Disease sites of female genital tract cancers of BRCA1/2-associated hereditary breast and ovarian cancer (HBOC) are less understood than non-hereditary cancers. We aimed to elucidate the disease site distribution of genital cancers in women with the germline BRCA1 and BRCA2 pathogenic variants (BRCA1+ and BRCA2+) of HBOC. For the primary disease site, the proportion of fallopian tube and peritoneal cancer was significantly higher in BRCA2+ (40.5%) compared with BRCA1+ (15.4%) and BRCA− (no pathogenic variant, 12.8%). For the metastatic site, the proportion of peritoneal dissemination was significantly higher in BRCA1+ (71.9%) than BRCA− (55.1%) and not different from BRCA2+ (71.4%). With one of the most extensive patients, this study supported the previous reports showing that the pathogenic variants of BRCA1/2 were involved in the female genitalia’s disease sites.

Objectives: The prevalence rate of migraines is 8.4%; it is mostly diagnosed in women at 20s to 40s, and is known to cause major physical and mental disruption to daily life. This study was conducted on women aged between their 20s and 40s, in order to investigate the possible differences in the features of the occlusal state between a migraine and a non-migraine (control) group.Methods: Age-matched female patients with migraine (n = 60) diagnosed by headache specialists and healthy controls (n = 57) were enrolled. Dental casts were used to evaluate some features.Results: The maxillary and mandibular dentition casts from the migraine group showed significantly characteristic findings in their Angle’s classification, overjet, and deviation in the anterior tooth midline, compared to the control group.Discussion: The results relating occlusal state to both tension-related headaches and migraines, which have different pathogeneses, suggest the possibility of dental intervention to improve the symptoms of prim...

Objective The nerve growth factor (NGF) family comprises of NGF, brain-derived neurotrophic factor (BDNF) and neurotrophins (NTs)-3 to -7, all of which are collectively referred to as NTs. However, the expression of NTs other than NGF in the salivary gland has not been described in detail. BDNF is a well-studied NT involved in the neurogenesis, differentiation, and maintenance of select peripheral and central populations of neuronal cells during development and adulthood. NTs, in concert with the hypothalamic–pituitary–adrenal (HPA) axis, play key roles in modulating brain plasticity and behavioral coping, especially during ontogenetically critical periods, when the developing brain is particularly sensitive to external stimuli. Early life events, such as psychophysical stress, affect BDNF levels, and induce dysregulation of the HPA axis, thereby affecting brain development and contributing to inter-individual differences in vulnerability to stress or psychiatric disorders. Immobilization stress modifies BDNF mRNA expression in some organs. Results We studied the effect of immobilization stress on BDNF and its receptor, tyrosine receptor kinase B (TrkB), in rat submandibular glands, and found increased BDNF expression in duct cells under immobilization stress. In addition, stress increases the amount of plasma BDNF derived from the submandibular gland, and the amount of TrkB receptor mRNA in the adrenal medulla. Conclusions Plasma BDNF might therefore activate TrkB receptors in the adrenal medulla during acute stress. The salivary glands are also likely to influence not only oral health, but also systemic organs. This review addresses the relationship between BDNF and stress in the saliva and salivary glands.

Objectives: Details on grinding patterns and types of contact during sleep bruxism in association with migraine headache have not yet been elucidated. This study compared the characteristics of sleep bruxism between patients with migraine and controls.Methods: The study included 80 female patients who had been diagnosed with migraine and 52 women with no history of migraine. Grinding patterns were measured using the BruxChecker® (Scheu Dental, Iserlohn, Germany).Results: There was a significant difference between the two groups in the distribution of grinding patterns at the laterotrusive side (p

In recent years, research has progressed about the relevance of the Temporomandibular joint (TMJ) and headache, we also feels malocclusion are involved in the background. However, induction factors of migraine are many. In this study, we carried out splint therapy for migraine patients. We summarize the features of malocclusion and its effectiveness.

Temporomandibular joint (TMJ) is acting as the only diarthrodial joint in the crania. Therefore, disorders of muscles and TMJ are frequently caused by disharmony of occlusion. It generally showed patients malocclusion and temporomandibular disorders (TMD) treatment of a large number of patients resulted in significant improvement in the physiological state of the general condition and some indefinite complaints including the primary headache.