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5 results on '"O'Loughlin, P"'

2. Knowledge Gains and Changing Attitudes from the Anatomy Education Research Institute (AERI 2017): A Mixed Methods Analysis

Author

Husmann, Polly R., O'Loughlin, Valerie D., and Brokaw, James J.

Abstract

The inaugural Anatomy Education Research Institute (AERI 2017) was held in Bloomington, Indiana in July of 2017. This workshop style conference paired experienced educational researchers (invited speakers) with individuals interested in learning more about the field (accepted applicants). In 2017, AERI was held over a five-day period and entailed plenary style presentations, break-out sessions, and specific times for small group mentorship. All participants (applicants and invited speakers) completed a pre-conference survey at the beginning of the institute and a post-conference survey at the end of the institute. Both surveys included categorical and Likert scale questions as well as open-ended questions for participant feedback. Quantitative and qualitative analyses indicate that both applicants and speakers increased their knowledge of anatomy education research, but that additional obstacles remain. Funding, time, and a lack of respect for the field remain problematic for faculty that wish to complete educational research. Mentorship and a community of practice also emerged as major themes necessary for educational research to be successful.

Published
2020
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3. Transanal total mesorectal excision: international registry results of the first 720 cases

Author

Penna M, Hompes R, Arnold S, Wynn G, Austin R, Warusavitarne J, Moran B, Hanna GB, Mortensen NJ, Tekkis PP, Albert M, Al Furajii H, Allison A, Arezzo A, Aryal K, Ashraf S, Atallah S, Baig K, Baral J, Bemelman W, Berger D, Boni L, Bonjer J, Bordeianou L, Borreca D, Buchs NC, Cahill R, Campbell K, Capolupo G, Caricato M, Cassinotti E, Chambers W, Courtney ED, Cunningham C, Dalton S, Dawson R, Delrio P, de Graaf E, De Paolis P, D'Hondt M, D'Hoore A, Doornebosch P, Erikson JR, Estevez-Schwarz L, Fabryko M, Fernandez-Hevia M, Forsmo H, Francis N, Garimella V, Gecim IE, Geissmann D, Gill K, Glockler M, Grieco M, Grolich T, Guy R, Hayes J, Hoffman TJ, Houben B, Ito M, Jelic F, Jones O, Joy H, Kala Z, Katory M, Kneist W, Knol J, Korsgen S, Kukreja N, Kunz R, Lacy A, Lal R, Lang H, La Vaccara V, Lezoche E, Lima MA, Mamedli Z, Mansfield S, Marsanic P, Mellano A, Mendes CRS, Merrie A, Miles A, Miroshnychenko Y, Morino M, Muratore A, Nicol D, Oh JH, O'Loughlin P, Pandey S, Paraoan M, Pei CFW, Perez RO, Pfeffer F, Picchetto A, Pockney P, Radley S, Rasulov A, Rega D, Ris F, Riss S, Sains P, Samarasinghe S, Juliao GPS, Seitinger G, Shaikh I, Sietses C, Sileri P, Fernandez VS, Smith S, Sohn DK, Speakman C, Stevenson A, Stift A, Sylla P, Tanis P, Teso EP, Tuech JJ, Tuynman J, van der Zaag E, van Duijvendijk P, Van Nieuwenhove Y, Vansteenkiste F, Velthuis S, Venkatsubramaniam A, Vorburger S, Wassenaar E, Wegstapel H, Wolthuis A, Wu L, Penna, M, Hompes, R, Arnold, S, Wynn, G, Austin, R, Warusavitarne, J, Moran, B, Hanna, Gb, Mortensen, Nj, Tekkis, Pp, Albert, M, Al Furajii, H, Allison, A, Arezzo, A, Aryal, K, Ashraf, S, Atallah, S, Baig, K, Baral, J, Bemelman, W, Berger, D, Boni, L, Bonjer, J, Bordeianou, L, Borreca, D, Buchs, Nc, Cahill, R, Campbell, K, Capolupo, G, Caricato, M, Cassinotti, E, Chambers, W, Courtney, Ed, Cunningham, C, Dalton, S, Dawson, R, Delrio, P, de Graaf, E, De Paolis, P, D'Hondt, M, D'Hoore, A, Doornebosch, P, Erikson, Jr, Estevez-Schwarz, L, Fabryko, M, Fernandez-Hevia, M, Forsmo, H, Francis, N, Garimella, V, Gecim, Ie, Geissmann, D, Gill, K, Glockler, M, Grieco, M, Grolich, T, Guy, R, Hayes, J, Hoffman, Tj, Houben, B, Ito, M, Jelic, F, Jones, O, Joy, H, Kala, Z, Katory, M, Kneist, W, Knol, J, Korsgen, S, Kukreja, N, Kunz, R, Lacy, A, Lal, R, Lang, H, La Vaccara, V, Lezoche, E, Lima, Ma, Mamedli, Z, Mansfield, S, Marsanic, P, Mellano, A, Mendes, Cr, Merrie, A, Miles, A, Miroshnychenko, Y, Morino, M, Muratore, A, Nicol, D, Oh, Jh, O'Loughlin, P, Pandey, S, Paraoan, M, Pei, Cfw, Perez, Ro, Pfeffer, F, Picchetto, A, Pockney, P, Radley, S, Rasulov, A, Rega, D, Ris, F, Riss, S, Sains, P, Samarasinghe, S, Juliao, Gp, Seitinger, G, Shaikh, I, Sietses, C, Sileri, P, Fernandez, V, Smith, S, Sohn, Dk, Speakman, C, Stevenson, A, Stift, A, Sylla, P, Tanis, P, Teso, Ep, Tuech, Jj, Tuynman, J, van der Zaag, E, van Duijvendijk, P, Van Nieuwenhove, Y, Vansteenkiste, F, Velthuis, S, Venkatsubramaniam, A, Vorburger, S, Wassenaar, E, Wegstapel, H, Wolthuis, A, Wu, L, Surgery, CCA - Cancer Treatment and quality of life, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and AGEM - Digestive immunity

Subjects
Male, SURGERY, medicine.medical_treatment, Anal Canal, registry, Body Mass Index, 0302 clinical medicine, Postoperative Complications, Risk Factors, PATHOLOGICAL OUTCOMES, Registries, Intraoperative Complications, Neoadjuvant therapy, Digestive System Surgical Procedures, 11 Medical and Health Sciences, Aged, 80 and over, education.field_of_study, Anal canal, Middle Aged, Total mesorectal excision, Neoadjuvant Therapy, RANDOMIZED CLINICAL-TRIAL, Dissection, medicine.anatomical_structure, Treatment Outcome, transanal total mesorectal excision, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Female, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, Adolescent, Population, Perforation (oil well), LOW-RECTAL-CANCER, Rectum, 03 medical and health sciences, Young Adult, medicine, Humans, Minimally Invasive Surgical Procedures, education, rectal cancer, MARGIN INVOLVEMENT, Mesorectal, Aged, Neoplasm Staging, Science & Technology, poor histological outcomes, LAPAROSCOPIC-ASSISTED RESECTION, business.industry, Rectal Neoplasms, TaTME Registry Collaborative, Surgery, Surgery, poor histological outcomes, rectal cancer, registry, risk factors, transanal total mesorectal excision, business
Abstract

OBJECTIVE: This study aims to report short-term clinical and oncological outcomes from the international transanal Total Mesorectal Excision (taTME) registry for benign and malignant rectal pathology. BACKGROUND: TaTME is the latest minimally invasive transanal technique pioneered to facilitate difficult pelvic dissections. Outcomes have been published from small cohorts, but larger series can further assess the safety and efficacy of taTME in the wider surgical population. METHODS: Data were analyzed from 66 registered units in 23 countries. The primary endpoint was "good-quality TME surgery." Secondary endpoints were short-term adverse events. Univariate and multivariate regression analyses were used to identify independent predictors of poor specimen outcome. RESULTS: A total of 720 consecutively registered cases were analyzed comprising 634 patients with rectal cancer and 86 with benign pathology. Approximately, 67% were males with mean BMI 26.5 kg/m. Abdominal or perineal conversion was 6.3% and 2.8%, respectively. Intact TME specimens were achieved in 85%, with minor defects in 11% and major defects in 4%. R1 resection rate was 2.7%. Postoperative mortality and morbidity were 0.5% and 32.6% respectively. Risk factors for poor specimen outcome (suboptimal TME specimen, perforation, and/or R1 resection) on multivariate analysis were positive CRM on staging MRI, low rectal tumor CONCLUSIONS: TaTME appears to be an oncologically safe and effective technique for distal mesorectal dissection with acceptable short-term patient outcomes and good specimen quality. Ongoing structured training and the upcoming randomized controlled trials are needed to assess the technique further.

Published
2017
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4. ARE STANDARDS AND EVIDENCE SUFFICIENT?

Author

O'Loughlin, Kathleen T. and Compton, Robert

Subjects
EVIDENCE-based dentistry, MEDICINE, PATIENTS, DISEASES, GUIDELINES, COST, INSURANCE, DIAGNOSIS, THERAPEUTICS
Abstract

The origins of standards and guidelines in medicine are traced from work in the 1970s showing that treatment variations could not be accounted for by objective differences in the disease or other conditions of patients. Guidelines based on evidence can be effective in reducing such variation and in reducing costs. However, population disparities in disease and access, as well as dramatically rising insurance costs, pose challenges. Standards based entirely on efficacy of procedures will leave unanswered important questions about diagnosis and effective allocation of resources throughout population groups. [ABSTRACT FROM AUTHOR]

Published
2005

5. Osteocyte cell density is reduced during vitamin D depletion and predicts osteoclast surface and bone mineral volume

Author

A.J. Moore, Gerald J. Atkins, Rebecca K. Sawyer, Paul H. Anderson, Howard A. Morris, Peter D. O’Loughlin, Anderson, Paul, Sawyer, Rebecca, Moore, A, Atkins, G, O'Loughlin, P, and Morris, H

Subjects
Bone mineral, Histology, medicine.anatomical_structure, Volume (thermodynamics), Physiology, Osteoclast, Chemistry, Endocrinology, Diabetes and Metabolism, Osteocyte, Cell density, medicine, Vitamin D and neurology, Biophysics
Abstract

Although the association between hip fracture risk and vitamin D deficiency is well established, understanding of the cellular mechanisms is less clear. Previously, we have reported maintaining adequate levels of serum 25-hydroxyvitamin D (25D) prevent bone loss by reducing RANKL-mediated osteoclastic bone resorption in an animal model. Interestingly, it has been demonstrated that increased bone resorption is mediated by osteocytes (OCY) either via apoptosis or trans-cellular signalling. Hence, we have used our vitamin D-deplete animal model to investigate the relationship between trabecular bone OCY cell density and other bone variables.

Published
2009
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