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Supplemental material, sj-pdf-1-wso-10.1177_1747493020984073 for Tenecteplase in wake-up ischemic stroke trial: Protocol for a randomized-controlled trial by Melinda B Roaldsen, Haakon Lindekleiv, Agnethe Eltoft, Mirza Jusufovic, Mary-Helen Søyland, Jesper Petersson, Bent Indredavik, Arnstein Tveiten, Jukka Putaala, Hanne Christensen, Janika Kõrv, Dalius Jatužis, Stefan T Engelter, Gian Marco De Marchis, Tom Wilsgaard, David J Werring, Thompson Robinson, Ellisiv B Mathiesen and Eivind Bergenr in International Journal of Stroke

Supplemental material, sj-pdf-1-wso-10.1177_1747493020984073 for Tenecteplase in wake-up ischemic stroke trial: Protocol for a randomized-controlled trial by Melinda B Roaldsen, Haakon Lindekleiv, Agnethe Eltoft, Mirza Jusufovic, Mary-Helen Søyland, Jesper Petersson, Bent Indredavik, Arnstein Tveiten, Jukka Putaala, Hanne Christensen, Janika Kõrv, Dalius Jatužis, Stefan T Engelter, Gian Marco De Marchis, Tom Wilsgaard, David J Werring, Thompson Robinson, Ellisiv B Mathiesen and Eivind Bergenr in International Journal of Stroke

Supplemental material, sj-pdf-1-wso-10.1177_1747493020984073 for Tenecteplase in wake-up ischemic stroke trial: Protocol for a randomized-controlled trial by Melinda B Roaldsen, Haakon Lindekleiv, Agnethe Eltoft, Mirza Jusufovic, Mary-Helen Søyland, Jesper Petersson, Bent Indredavik, Arnstein Tveiten, Jukka Putaala, Hanne Christensen, Janika Kõrv, Dalius Jatužis, Stefan T Engelter, Gian Marco De Marchis, Tom Wilsgaard, David J Werring, Thompson Robinson, Ellisiv B Mathiesen and Eivind Bergenr in International Journal of Stroke

Supplemental material, sj-pdf-1-eso-10.1177_2396987320925205 for Patterns in hospital readmissions after ischaemic stroke – An observational study from the Swedish stroke register (Riksstroke) by Stefan Sennfält, Jesper Petersson, Teresa Ullberg and Bo Norrving in European Stroke Journal

Supplemental material, sj-pdf-1-eso-10.1177_2396987320925205 for Patterns in hospital readmissions after ischaemic stroke – An observational study from the Swedish stroke register (Riksstroke) by Stefan Sennfält, Jesper Petersson, Teresa Ullberg and Bo Norrving in European Stroke Journal

Supplemental material, ESO883154 Supplemental Material for Long-term outcome after ischemic stroke in relation to comorbidity – An observational study from the Swedish Stroke Register (Riksstroke) by Stefan Sennfält, Mats Pihlsgård, Jesper Petersson, Bo Norrving and Teresa Ullberg in European Stroke Journal

The original version of this consensus statement on mechanical thrombectomy was approved at the European Stroke Organisation (ESO)-Karolinska Stroke Update conference in Stockholm, 16–18 November 2014. The statement has later, during 2015, been updated with new clinical trials data in accordance with a decision made at the conference. Revisions have been made at a face-to-face meeting during the ESO Winter School in Berne in February, through email exchanges and the final version has then been approved by each society. The recommendations are identical to the original version with evidence level upgraded by 20 February 2015 and confirmed by 15 May 2015. The purpose of the ESO-Karolinska Stroke Update meetings is to provide updates on recent stroke therapy research and to discuss how the results may be implemented into clinical routine. Selected topics are discussed at consensus sessions, for which a consensus statement is prepared and discussed by the participants at the meeting. The statements are advisory to the ESO guidelines committee. This consensus statement includes recommendations on mechanical thrombectomy after acute stroke. The statement is supported by ESO, European Society of Minimally Invasive Neurological Therapy (ESMINT), European Society of Neuroradiology (ESNR), and European Academy of Neurology (EAN).

BACKGROUND: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive.OBJECTIVE: To assess the associations between alcohol consumption and PD risk.METHODS: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence.RESULTS: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD.CONCLUSION: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Background/Aims: Large epidemiological prospective studies represent an important opportunity for investigating risk factors for rare diseases such as Parkinson's disease (PD). Here we describe the procedures we used for ascertaining PD cases in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: The following three-phase procedure was used: (1) elaboration of a NeuroEPIC4PD template for clinical data collection, (2) identification of all potential PD cases via record linkage and (3) validation of the diagnosis through clinical record revision, in a population of 220,494 subjects recruited in 7 European countries. All cases were labelled with the NeuroEPIC4PD diagnoses of ‘definite', ‘very likely', ‘probable', or ‘possible' PD. Results: A total of 881 PD cases were identified, with over 2,741,780 person-years of follow-up (199 definite, 275 very likely, 146 probable, and 261 possible). Of these, 734 were incident cases. The mean age at diagnosis was 67.9 years (SD 9.2) and 458 patients (52.0%) were men. Bradykinesia was the most frequent presenting motor sign (76.5%). Tremor-dominant and akinetic rigid forms of PD were the most common types of PD. A total of 289 patients (32.8%) were dead at the time of the last follow-up. Conclusions: This exercise proved that it is feasible to ascertain PD in large population-based cohort studies and offers a potential framework to be replicated in similar studies.

Previous case–control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected thorough standardised questionnaires. Total PA was expressed by the Cambridge Physical Activity Index (CPAI) and analysed in relation to ALS mortality, using Cox hazard models. Interactions with age, sex, and anthropometric measures were assessed. Total PA was weakly inversely associated with ALS mortality with a borderline statistically significant trend across categories (p = 0.042), with those physically active being 33 % less likely to die from ALS compared to those inactive: HR = 0.67 (95 % CI 0.42–1.06). Anthropometric measures, sex, and age did not modify the association with CPAI. The present study shows a slightly decreased—not increased like in case–control studies—risk of dying from ALS in those with high levels of total PA at enrolment. This association does not appear confounded by age, gender, anthropometry, smoking, and education. Ours was the first prospective cohort study on ALS and physical activity. Electronic supplementary material The online version of this article (doi:10.1007/s10654-016-0119-9) contains supplementary material, which is available to authorized users.

Supplemental Material for Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial by H Bart van der Worp, Malcolm R Macleod, Philip MW Bath, Raj Bathula, Hanne Christensen, Bridget Colam, Charlotte Cordonnier, Jacques Demotes-Mainard, Isabelle Durand-Zaleski, Christian Gluud, Janus Christian Jakobsen, Bernd Kallmünzer, Rainer Kollmar, Derk W Krieger, Kennedy R Lees, Dominik Michalski, Carlos Molina, Joan Montaner, Risto O Roine, Jesper Petersson, Richard Perry, Nikola Sprigg, Dimitre Staykov, Istvan Szabo, Geert Vanhooren, Joanna M Wardlaw, Per Winkel, Stefan Schwab and the EuroHYP-1 investigators in European Stroke Journal