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Complexation of cobalt(II) chloride with apple pectin modified with organic pharmacophores (nicotinic, salicylic, 5-aminosalicylic, or anthranilic acid) has been studied by spectral methods. Molar composition, stability constants of the complexes, and pH range of their existence have been determined; standard thermodynamic characteristics (ΔH°, ΔG°, ΔS°) of the complexes formation have been calculated. it has been shown that cobalt(II) ions form complexes of different stability with pharmacophore-containing pectins, which may be due to the unequal affinity of the metal ions to the donor groups of the monomer unit of the polysaccharide matrices.

Preparation of a polyelectrolyte complex of chitosan with the oxidized form of Siberian larch arabinogalactan at the component ratio from 0.05: 1 to 1: 1 was studied by spectrometry and laser scattering. Water-insoluble films based on this complex were prepared. These films were used as a matrix for drug immobilization. The possibility of controlling the rate and degree of the drug release from the film by variation of the polysaccharide ratio, modification of the polymer film with a sodium dodecyl sulfate solution, or heat treatment was demonstrated with cefazolin antibiotic as example. The films obtained exhibit high bactericidal activity.

A procedure was developed for preparing stable iodine-containing films and powders based on pectin and pectin-nicotinic acid complex; their high bactericidal activity was revealed. The complexation relationships in the pectin-iodine and pectin-nicotinic acid-iodine systems were studied by spectrophotometry. The optimum preparation conditions, compositions, and stability constants of the complexes were determined. The dynamics of iodine release from the films and powders was studied.

Interaction of citrus pectin with cefotaxime and 4-methyl-5-oxymethyluracyl was studied by spectrophotometric methods. New film coatings with these medicinal preparations for mesh implants were produced on the basis of the citrus pectin-polyvinyl alcohol matrix. It was demonstrated that supramolecular formations of the polymeric formulation affect the transport properties of the films. A high antibacterial activity of film coatings with cefotaxime was revealed.

Physicochemical methods were used to study the interaction of arabinogalactan from Siberian larch with the antibacterial preparation levofloxacin. Polymeric eye films with controllable output of the medicinal preparation were produced on the basis of an arabinogalactan-polyvinyl alcohol formulation. A high pharmaceutical activity of the new eye films was demonstrated.

Special features of the formation of 2-benzoylaminobenzimidazole complexes with copper(II) chloride, sulfate, and acetate were studied. Optimal conditions of obtaining the complexes were found, and chemical compositions, some physicochemical properties, and fungicidal activity of the synthesized compounds were studied.

Interaction of oxidized arabinogalactan of Siberian larch (Larix Sibirica L.) with Kanamycin antibiotic in aqueous solutions was studied by physicochemical methods. The composition and stability constant of the complex formed were determined, the possible reaction scheme was analyzed, and the optimal reaction conditions were found. The physiological activity of the compound obtained was revealed.

The possibility of using heat treatment (∼120°C) for controlling the drug release from chitosan films prepared from acetic acid solutions and containing antibiotics cefazolin and cefotaxime was examined.

Some aspects of the complexation of chitosan with an antibiotic cefazolin were studied. The optimal conditions for synthesis of the complexes were found. Their composition and physicochemical properties were analyzed.

By means of the UV, IR, and NMR spectroscopy, densimetry and viscometry reaction of arabinogalactan from Sibirian larch with kanamycin in water solutions was studied. The composition and the stability constant of the complex formed were evaluated, and optimal conditions of its synthesis were established.

Complex formation of chitosan with Amikacin and Gentamicin antibiotics was studied. The optimal conditions for preparing the complexes were found.

Features of complexation of chitosan with Cefotaxime antibiotic were examined. Optimal conditions for preparing the complexes were found, and their chemical composition and physicochemical properties were studied.