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We analyzed the cost-effectiveness of the International Conference on Harmonisation (ICH) E14 guideline that requires a thorough QT/QTc (TQT) study for all drugs under development. We compared two pharmacoeconomic scenarios: the health effects and costs resulting from implementing ICH E14 ("regulation" scenario) vs. not implementing ICH E14 ("no regulation" scenario). We used a dynamic population model to calculate the cost-effectiveness of ICH E14 for a prototype QT-prolonging antipsychotic drug entering the US and European markets. The incremental cost-effectiveness ratios of regulation vs. no regulation were ~€2.4 million per sudden cardiac death prevented and ~€187,000 per quality-adjusted life year (QALY) gained in users of antipsychotic drugs. The main driver of cost was the requirement for electrocardiogram (ECG) monitoring of users of QTc-prolonging drugs. Even when several of the assumptions in the model were varied, there were no results in favor of regulation. Our study shows that cost-effectiveness analysis of drug regulatory measures is feasible and should be considered before developing such measures.

Data from Mehsana kids born during the period of 2006 to 2012, maintained at Sheep and Goat Research Station (SGRS), Sardarkrushinagar Dantiwada Agricultural University, Gujarat, India, were used to evaluate the effect of various non-genetic factors on the different growth traits. The least squares means of body weights at birth, 3 months, 6 months, 9 months and 12 months of age were 2.75 ± 0.03, 10.33 ± 0.16, 13.83 ± 0.23, 16.98 ± 0.35 and 20.44 ± 0.31 kg, respectively. The pre-weaning and post-weaning average daily weight gains were 84.75±1.82, and 35.58±0.92 g, respectively. Although year of birth was having highly significant

Summary Double-stem Swanson silastic arthroplasty was performed without grommets on the first metatarsophalangeal joints of 45 patients (62 feet). After a mean follow-up of 7 years 3 months (range, 5 years 1 month–9 years 10 months), 91% had been helped greatly with survivorship analysis revealing 94.4% implant survival at 10 years and significant improvements in scores for pain, ambulation, function and shoe wear ( P P

The pattern of growth and regression of ovarian follicles was monitored once daily for one complete estrous cycle in eight individual water buffaloes by ultrasonographic scanning of the ovaries for an entire interovulatory interval of normal cycle length. One-wave follicular growth was observed in five animals and two-wave follicular growth in three buffaloes during the estrous cycle. The first follicular wave of a two-wave cycle emerged significantly earlier (P0.05) than the emergence of the solitary wave of a one-wave cycle. One- and two-wave cycles differed significantly (P0.05) with respect to the mean interovulatory interval (21.0 +/- 0.54 days versus 22.7 +/- 0.33 days) and the mean interestrus interval (20.8 +/- 0.58 days versus 22.3 +/- 0.66 days). The overall linear growth rate of the ovulatory follicle was significantly greater (P0.01) in a two-wave cycle compared to that of a one-wave cycle (1.17 +/- 0.33 mm/day versus 0.32 +/- 0.01 mm/day). In a one-wave pattern, the growth profile of the solitary dominant follicle was atypical, showing three distinct phases, i.e. growth phase, regression phase and regrowth phase culminating in ovulation. The level of plasma progesterone steadily increased from day 0 of estrous cycle, attained peak level on day 14 and declined thereafter. A slower growth rate of the dominant follicle was observed in the presence of higher plasma progesterone concentration. The present study shows that one-wave follicular growth is a normal phenomenon in suckled water buffaloes.