1. Risk Factors for Failure of Splenic Angioembolization: A Multicenter Study of Level I Trauma Centers
- Author
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S. Rob Todd, Brittany Bankhead-Kendall, Jason Murry, Carlos V.R. Brown, Michael L. Foreman, David Archer, Justin L. Regner, Kelly Harrell, Sharmila Dissanaike, Carlos Rodriguez, Alan H. Tyroch, Tashinga Musonza, Adel Alhaj-Saleh, Stephen Pan, Lillian S. Kao, Pedro G.R. Teixeira, and Timothy R. Donahue
- Subjects
Adult ,Male ,medicine.medical_specialty ,Blood transfusion ,Adolescent ,Computed Tomography Angiography ,medicine.medical_treatment ,Splenectomy ,Abdominal Injuries ,Logistic regression ,Time-to-Treatment ,law.invention ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Primary outcome ,Trauma Centers ,Risk Factors ,law ,Humans ,Medicine ,Blood Transfusion ,Treatment Failure ,Embolization ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Length of Stay ,Middle Aged ,Embolization, Therapeutic ,Intensive care unit ,Massive transfusion ,Surgery ,Multicenter study ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,business ,Splenic Artery ,Spleen - Abstract
Angioembolization (AE) is an adjunct to nonoperative management (NOM) of splenic injuries. We hypothesize that failure of AE is associated with blood transfusion, grade of injury, and technique of AE.We performed a retrospective (2010-2017) multicenter study (nine Level I trauma centers) of adult trauma patients with splenic injuries who underwent splenic AE. Variables included patient physiology, injury grade, transfusion requirement, and embolization technique. The primary outcome was NOM failure requiring splenectomy. Secondary outcomes were mortality, complications, and length of stay.A total of 409 patients met inclusion criteria; only 33 patients (8%) required delayed splenectomy. Patients who failed received more blood in the first 24 h (P = 0.009) and more often received massive transfusion (P = 0.01). There was no difference in failure rates for grade of injury, contrast blush on computed tomography, and branch embolized. After logistic regression, transfusion in the first 24 h was independently associated with failure of NOM (P = 0.02). Patients who failed NOM had more complications (P = 0.002) and spent more days in the intensive care unit (P 0.0001), on the ventilator (P = 0.0001), and in the hospital (P 0.0001). Patients who failed NOM had a higher mortality (15% versus 3%, P = 0.007), and delayed splenectomy was independently associated with mortality (odds ratio, 4.2; 95% confidence interval, 1.2-14.7; P = 0.03).AE for splenic injury leads to effective NOM in 92% of patients. Transfusion in the first 24 h is independently associated with failure of NOM. Patients who required a delayed splenectomy suffered more complications and had higher hospital length of stay. Failure of NOM is independently associated with a fourfold increase in mortality.
- Published
- 2021