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The elimination of malaria in the world is targeted in 2030. Java and Bali are targeted to get malaria elimination certification in 2023. The area in the Menoreh Hills, which is the border of 3 districts and two provinces, namely Magelang district and Purworejo district in Central Java Province; and Kulonprogo district, in Special Province of Yogyakarta. Magelang district has obtained a certificate of malaria elimination. This study uses a qualitative design with in-depth interviews with 4-6 informants in each district consisting of officers in the District Health Service, Public Health Center, District Planning and Development Agency, and People Welfare Unit in regional government. The activity was carried out from March 2018 to May 2019. The districts in the Menoreh Hills area have collaborated and held cross-regional meetings to eliminate malaria. Even though it had a different problem in human resources, funds, infrastructure, in general, cross-program has a role in the form of cooperation in activities that carried out together. The cross-sectoral involvement has not been seen much at the meeting, consolidation, and planning. Communities from three locations play a role in environmental cleanliness and migration surveillance. In the past, Magelang district has been active in collaborating cross-program and sectors as well as community participation compared to Kulonprogo and Purworejo districts, so that Magelang district can obtain a malaria elimination certificate first. However, currently, Kulonprogo and Purworejo districts have been active in collaborating cross-program and sectors, while in Magelang district are now weakening. The community already has awareness in the implementation of malaria migration surveillance. The community already has awareness in the implementation of malaria migration surveillance. Abstrak Eliminasi malaria di dunia ditargetkan pada tahun 2030. Jawa dan Bali ditargetkan mendapat sertifikasi eliminasi malaria pada tahun 2023. Kawasan Bukit Menoreh merupakan perbatasan dari 3 wilayah kabupaten dan 2 provinsi yaitu Magelang, Purworejo Provinsi Jawa Tengah dan Kabupaten Kulonprogo Provinsi Daerah Istimewa Yogyakarta. Saat ini, Kabupaten Magelang telah memperoleh sertifikat eliminasi malaria. Penelitian ini bertujuan menilai/menentukan status kemitraan/kerjasama, lintas program, lintas sektor dan peran serta masyarakat dalam eliminasi malaria. Penelitian ini menggunakan desain kualitatif dengan metode wawancara mendalam kepada 4-6 informan pada setiap kabupaten yang terdiri dari petugas di dinas kesehatan kabupaten, puskesmas, Badan Perencanaan dan Pembangunan Daerah (Bappeda), serta pemerintah daerah bagian kesejahteraan rakyat (Kesra). Kegiatan dilakukan pada bulan Maret 2018-Mei 2019. Kabupaten di Kawasan Bukit Menoreh telah melakukan kerjasama dan pertemuan lintas wilayah dalam menanggulangi malaria. Meskipun mempunyai kendala yang berbeda-beda dari segi SDM, dana, sarana pra sarana, secara umum peran lintas program berupa kerjasama dalam pelaksanaan kegiatan yang dilaksanakan bersama-sama. Lintas sektor yang terlibat belum banyak yang terlihat pada pertemuan, konsolidasi, dan perencanaan. Masyarakat dari ketiga lokasi berperan dalam kebersihan lingkungan, surveilans migrasi. Magelang lebih dahulu aktif melakukan kerjasama lintas program dan lintas sektor serta peran serta masyarakat dibandingkan Kulonprogo dan Purworejo sehingga dapat lebih dahulu memperoleh sertifikat eliminasi malaria. Saat ini kegiatan kerjasama lintas program dan sektor di kabupaten Magelang melemah. Sedangkan, Kulonprogo dan Purworejo telah aktif melakukan kerjasama lintas program dan lintas sektor serta peran serta masyarakat. Masyarakat sudah mempunyai kesadaran dalam pelaksanaan surveilans migrasi malaria.

Dengue prevention and control still depend on insecticides usage. Household insecticides were the most preferable choice to prevent and control Aedes aegypti at settlements. The purpose of this study was to analyze the usage of household insecticides to prevent and control Ae. aegypti in settlement, especially in North Sumatra Province. The research was conducted during April-November 2015. The larvae examination and interviews were conducted on 900 respondents in three districts in North Sumatra Province (Tebing Tinggi, Pematang Siantar and Deli Serdang). The results of the study showed that the house index, container index, breteau index and densty figure in three districts were revealed that the regions were at moderate and high risk of dengue transmission. Most people in three districts use household insecticide at night to prevent dengue transmission. In conclusion, the household insecticides usage by the community in North Sumatra Province is ineffective to Ae. aegypti prevent and control in settlements, because the community only use adulticide and the time of use of insecticide is not in accordance with the activities of Ae. aegypti to transmit DHF during the daytime without any larva control activity.

A skeletal-related event (SRE) is an event occurring due to bone metastasis in prostate cancer. SREs are usually marked by pain, pathological fractures, spinal cord compression, hypercalcemia, or bone metastasis requiring radiotherapy or operation. Case I: A 64-year-old male was diagnosed with a pathological fracture of the left femur. Thoracal CT scan showed osteoblastic lesions in the thoracal vertebrae, sternum, clavicle, and humeral head. Spinal MRI showed destruction of the cervical to sacral vertebral bodies. The histopathological result with Adenocarcinoma Gleason scores 8 (4+4) and an initial prostate-specific antigen (PSA) level of 689,7 ng/dL. Afterward, subcapsular orchiectomy was performed. However, his PSA level was still high (>100 ng/dL) even after serum testosterone had reached a castration level. The patient died during the first chemotherapy using docetaxel. Case II: A 61-year-old male was diagnosed with inferior paraplegia and neurogenic bladder, paraparesis, urinary retention, and pain in the flank area. Spinal MRI showed a pathological compression fracture of the 8th thoracic vertebrae. Thoracal CT scan showed costal and 8th thoracal vertebrae destruction as well as multiple nodules in the lungs. Histological results with Adenocarcinoma Gleason score 9 (4+5) and an initial PSA level of 750 ng/dL. Afterward, subcapsular orchiectomy was performed. Serum testosterone reached castration level with the lowest PSA concentration of 21.6 g/dL. The patient declined chemotherapy and agreed to palliative treatment. He died one year after diagnosis. A high PSA level (>500 ng/dL) could potentially be used as a predictor for severe SRE.

The Boercang goat is a crossbred between male Boer goat and local female goat. This study was aimed to analyze the production and physical performances of Boercang goats during the weaning up to the age of one year. Thirty nine males and 37 females goats aged 3 - 12 months were used in the study. Body weight, daily weight gain, coat colour pattern, horn, ears, nose shape and birth type were recorded during study. The data obtained were calculated for the means, standard deviation (SD), and coefficient of variation (CV) and the analysis was descriptive. Student t test was performed to compare differences between groups of age and between group of sex. Field observations showed that the qualitative characteristics of Boercang such as body colour, horns, ears, and nose shape were 50 % identical with the characteristics of male Boer. The average body weight of the male Boercang goats was 23.02±1.56 kg whereas the female Boercang goats was 21.86±1.63 kg. Body weight gain was affected by age and birth type. The conclusion is that the genetic superiority of the qualitative characteristics of the Boer goats is still expressed in the offspring although it varies; for the characteristics of horns, colour patterns and ears still contribute more than 50%. The appearance of superior quantitative traits from the male Boer goat during the period of weaning up to one year of age both based on the birth type and offspring sex tends to be higher than the appearance of local goat.

The human footprint (HF) was developed to measure of the impact of human activities on the environment. The human footprint has been found to be closely related to the vulnerability of protected areas around the world. In Indonesia, as nature conservation is still seen as hindering economic development, it is especially important to assess the human footprint in order to comprehend the overall pressures resulting from the various human activities on Indonesia’s national parks. This study measured the change in the human footprint in and around 43 terrestrial national parks over 5 years, between 2012 and 2017. As many as 37 out of 43 NPs experienced an increase in the HF, ranging from 0.4 to 77.3%. Tanjung Puting in Kalimantan experienced the greatest increase (77.3%), while Ujung Kulon in Jawa Bali bioregion had the greatest decrease (10.5%). An increase in human population density and improved access to parks from roads, rivers and coastlines are the main drivers of increasing impacts on national parks.

BACKGROUND: Normal pressure hydrocephalus (NPH) is characterized by an abnormal buildup of cerebrospinal fluid in the ventricles or cavities of the brain. The objective of the case report was to define the importance of physical medicine and rehabilitation intervention as an approach for an elderly patient with NPH. CASE REPORT: A 75-year-old woman presented with a balance and gait disturbance after injury from a motor vehicle accident. The patient experience Hakim’s triad (gait disturbance, urinary frequency, and mild cognitive impairment), and her computed tomography scan of the head revealed ventriculomegaly, multiple lacunar infarctions on the paraventricle, and cerebral atrophy, which could indicate NPH. Balance and gait training, cardiopulmonary training, and environment modification were interventions from physical medicine and rehabilitation provided to this patient. CONCLUSION: An elderly patient with NPH should receive physical medicine and rehabilitation intervention to prevent falls, improve functional ability, and improve quality of life.

Introduction: Increased aerobic exercise capacity appears to reduce all-cause mortality and cardiovascular mortality. Aerobic exercise improves functional capacity (FC) is strongly recommended.However, evidence regarding the most efficient exercise intensity for patients post Coronary Artery Bypass Surgery (CABG) is still limited. This study aimed to assess the effects of high-intensity intervalexercise (HIIT) compared to moderate-continous intensity exercise (MCT) for increasing FC in patients post CABG. Methods: True experimental pre-post study included 6 men post CABG participating in a phase II cardiac rehabilitation (CR) with age ≤ 65 years old, ejection fraction ≥ 40%, no heart failure, no valve disease.Each group had 3 participants. HIIT group exercise at 80-90% Heart Rate Reserve (HRR) followed by 60-70% HRR active rest periods, MCT group exercised at 60-80% HRR. Both groups trained 3 days/week for 4 weeks. FC measured at baseline and after 4 weeks of rehabilitation. FC was assessed by maximal exercise testing through indirect VO2 max measurement. Results: After training, FC increased significantly in both group HIIT: 0,98±0,48 METs (8.07±1.51 METs to 9.05±1.21 METs), p=0.03 and MCT : 0,79±1,03 METs (5.74±2.24 to 6.53±1.69 METs), p=0.04).Differences in FC improvement between the two groups are p=0.792. Conclusion: HIIT exercise had no difference with MCT in increasing FC in patients post CABG. Keywords: CABG, cardiac rehabilitation, continuous moderate training, functional capacity, highintensity interval training

Background This study aimed to assess the effects of exogenous SOD administration on prostate cancer cell line (PC-3) apoptosis via the intrinsic pathway by examining the expression of manganese superoxide dismutase (MnSOD), caspase-3, and apoptosis index of the PC-3 cell line. Methods We used the prostate cancer cells from secondary prostate cancer cell lines (PC-3) derived from castration refractory prostate cancer (CRPC), cell differentiation grade IV, and had metastasized to the bone from the American Type Culture Collection (ATCC, Rockville, MD, USA). Superoxide dismutase (SOD) is derived from extracts of melon seeds and wheat gliadin biopolymer, and divided into 62.5 mg/mL, 83 mg/mL, 125 mg/mL, and 250 mg/mL doses. Expression of MnSOD was measured by immunohistochemistry (IHC). Expression of caspase-3 was measured using Western Blot method. Apoptotic index is calculated based on the reaction introduction 3OH end of fragmentation of DNA by the enzyme terminal transferase in preparations with TUNEL staining reagents. A one-way ANOVA test and Pearson correlation test were used to determine the relationship between SOD with expression of caspase-3 and apoptotic index. Results SOD extract significantly increased the expression of caspase-3 (P=0.016) and the apoptotic index (P=0.000) (P

Pada Iklim kerja dengan suhu panas berawal dari timbulnya energi yang bersumber dari panas yang masuk ke lingkungan atau tempat kerja kemudian jadi tekanan yang panas, hal tersebut menjadi beban kerja tambahan untuk pekerja. Kondisi seperti itu memengaruhi kesehatan dan energi/ stamina pekerja jika dihubungkan dengan beban kerja berat yang dikerjakan. Kondisi Iklim kerja dengan suhu panas dapat memperberat kondisi kesehatan fisik dan mental pekerja. Dampak yang sering terjadi pada pekerja akibat iklim kerja panas yaitu dehidrasi dan keluhan kesehatan lain seperti heat rash. Tujuan dari penelitian ini adalah untuk mengetahui gambaran dan pengendalian iklim kerja dengan keluhan kesehatan pada pekerja, hasil tersebut nantinya akan dibandingkan dengan nilai ambang batas sehingga dapat dijadikan dasar dalam melakukan tindakan pengendalian dalam upaya pencegahan penyakit akibat kerja pada industri. Pengukuran Iklim kerja yang dilakukan pada bagian kerja di indutri pembuatan lilin, diketahui memiliki hasil yaitu sebagian besar memiliki nilai ISBB > 30oC. Berdasarkan pengamatan yang telah dilakukan beban kerja pada pekerja yaitu beban kerja dengan tingkatan sedang dengan waktu kerja 75% hingga 100% dengan 25% waktu beristirahat. Berdasarkan hasil rata-rata 10 titik dari ke dua bagian kerja di industri tersebut, sebagian besar nilai ISBB hasil pengukuran lebih besar dari nilai NAB yang telah ditetapkan, dengan nilai NAB 28oC. Pada keluhan kesehatan yang sering di rasakan oleh pekerja yaitu dehidrasi banyak dirasakan oleh pekerja karena pekerja yang jarang mencukupi asupan cairan atau air. Begitu pula pada keluhan heat rash, keluhan ini dirasakan para pekerja yang jarang menjaga hieginitas diri. Oleh sebab itu, perlunya pengendalian iklim kerja baik dalam lingkungannya maupun pekerjanya. Pengendalian tersebut seperti Training (pendidikan/latihan), Pengendalian tekanan panas melalui penerapan hygiene.

Extracorporeal shockwave lithotripsy (ESWL) is a commonly used procedure for kidney stones and ureters because it is a non-invasive, effective, and first-line therapy of the upper urinary tract. The presence of side effects is still being evaluated in order to reduce the incidence of both acute and chronic. One of the methods used is the measurement of Resistive Index (RI) in the area of ESWL. To provide a description of the difference in the value of RI in the interlobar artery that is near and distant from the stones at before and after ESWL. There were 15 samples with clinical kidney stones to be performed with ESWL at IIU and fulfilled inclusion criteria from June to September 2012. Paired samplet-test was conducted to assess the difference of RI value based on the distance of interlobar artery from stones between pre and post ESWL. Sex of the samples in this study consisted of 66.7% male and 33.3% female with mean age of 45.9±8.4 years (between 32-59 years old) and the highest percentage was 40% in the age range of 40-49 years old. There was a significant difference between the RI value of the area near the stones at pre-ESWL and an hour post-ESWL. While there was no significant difference between the RI value of the area that was away from the stones at pre and post ESWL. There was a significant difference between RI values based on the distance of interlobaris artery from stones at pre and post ESWL.

Diabetic feet ulcer is four times more likely to be found in patients who suffer from diabetes mellitus than in those who don't. Diabetic feet ulcer is one of chronic complications of diabetes mellitus which causes defects even deaths. Diabetes mellitus in one of the ten most frequent diseases in Indonesia. According to Riskesdas (Riset Kesehatan Dasar - Basic Health Research), the increment number of patients with diabetes mellitus from 2007 up to 2013 is 330,512.1 The research is aimed to find out the effect of oral hydrotherapy on risk reduction of diabetic feet ulcer in patients with type-2 diabetes mellitus. The research was done by applying quasi-experimental design (pre-test and post-test design with control group). By total population sampling, there were 68 respondents who participated. About 34 of the respondents were in experimental group at Dr. Soediran Mangun Sumarso of Wonogiri, and 34 respondents were patients who had check-ups at RS PKU Muhammadiyah of Surakarta. The research result shows that oral hydrotherapy can minimize risk reduction of diabetic feet ulcer in patients with type-2 diabetes mellitus significantly with p-value of 000.0 (α=0.005).

Dust is one type of potential hazardzs in the workplace that can affect the health of the workers. The occupation that are always exposed to dust is furniture industry workers so that they have higher risk of getting acute respiratory tract infection (ARI) disorder which can interfere with breathing. The wood dust is formed from some of the sawn wood and sanding that will lead to an acute respiratory tract infection. The study aimed to determine the effect of environmental factor and the use of Personal Protective Equipment (PPE) against the symptoms of acute respiratory infections in the furniture industry workers. The research method used was quantitative method with observational and cross-sectional research types and it was analysed by using logistic regression test. The population in this study was the workers of the furniture industry at Semarang street, Surabaya City, with a total of 57 people, of which 37 furniture workers as a sample. The results show that most of the workers has symptoms of acute respiratory tract infection. It could be influenced by the environmental factor such as dust exposure that produced wood dust in each manufacturing processes. Additionally, the use of PPE also affected the occurrence of acute respiratory tract infections symptoms in the workers. In conslusion, many factors can influence the occurrence of acute respiratory tract infection symptoms in the furniture industry workers. Therefore, it is necessary to minimize the dust exposure in workers by wearing PPE such as respirators.

Background: Physiotherapy service standards are used as a basis for risk management in preparing strategies to anticipate unexpected events that appear in the management of the physiotherapy process. This research aims to improve the quality of physiotherapy services through the calculation of the risk of the physiotherapy process and risk mitigation measures using the Workload Indicator Staffing Need (WISN) method from the World Health Organization (WHO). Methods: The research uses the stages of risk management as a method of analysis and WISN as a method for risk mitigation. Risk analysis begins with the identification of risks and then measures the risks by calculating the probabilities and impacts of these risks and designing risk management as mitigation. Results: Based on the research that has average 50-60/day, which is not proportional to the number of only 4 physiotherapists. In addition, there is a lack of physiotherapy intervention tools. Conclusion: In this research it has concluded that to improve the quality of physiotherapy services must be done by making policies to mitigate unexpected events and reducing the probabilities such as: increasing the number of physiotherapists and arranging the separation schedule of examination days for physiotherapy been done, events with the highest risk are found in the stages of examination and measurement, documentation, and physiotherapy intervention where there is an opportunity to reduce the type and duration of long or unsuccessful healing interventions. The trigger for the occurrence of potential risks is the number of patients on measurements from intervention days and increasing the number of physiotherapy intervention tools.

Background Urethral reconstruction has been a problem for a long time and is a major challenge for surgeons. Surgical management of urethral defects is still controversial because there is no synthetic material that is considered ideal as a substitute for the urethra. With the development of adipose-derived mesenchymal stem cells, this research aims to observe the difference between the use of dried amniotic membrane as a scaffold with and without mesenchymal stem cells seeding as graft in urethral reconstruction. Methods This research was a pure experimental research with a post-test only control group design using 24 male New Zealand white rabbits. The samples were divided into 3 groups: one control group, one scaffold (dried amniotic membrane) without stem cell seeding group, and one stem cell-seeded scaffold group. The rabbits were evaluated at 28 days after treatment and the results were analyzed using Chi-Square test. Results The number of urethras that were healed were higher in stem cell-seeded scaffold compared to scaffold without stem cell seeding group (p Conclusion Considering the promising result, application of dried amniotic membrane as a scaffold with adipose-derived mesenchymal stem cell seeding could be an option for urethral reconstruction.

Introduction: Indonesia is a high incidence country of multidrug-resistant tuberculosis. There are approximately 11,000 MDR TB cases, 2.8% of them are new cases and 16% of them are relapse cases. Although guidelines for MDR-TB are frequently designed, medication freely provided, and centers for treatment duly expanded, studies on time to sputum culture conversion have been very limited in Indonesia. Therefore the aim of the study is to identify risk factors that effect on sputum and culture conversion.Methods: Data on short-term regimen for MDR TB in Dr. Soetomo General Hospital from January 1st – December 31st, 2018 were collected with a total sampling approach, and fulfill the inclusion and exclusion. Data were analyzed by computer software IBM SPSS Statistic 24 for windows. Results: Male is more likely to have delayed sputum conversion and culture conversion but no statistical difference is observed (p>0.05). Smoking history is more likely to have delayed sputum and culture conversion but only in sputum smear test shows a significant difference (p≤ 0.05). Alcohol consumption has delay effect on sputum and culture conversion but there is statistically difference in only culture conversion (p

Background: Coping mechanism is a process whereby individuals try to handle and master stressful situations that suppress the consequences of the problems it faces, it is very necessary in patients with psychiatric. Purpose : The purpose of this study was to analyze the effect of pre- and post-intervention therapy on cooperative mechanisms of cooperative schizophrenia Methods : The research design used in this research is experimental pre with one group pretest and posttest approach where the mechanism of client cloning before and after Schizophrenia is given intervention in the form of prayer therapy. The analysis used is descriptive where the data is taken directly on each respondent, the score obtained from each respondent will be adjusted with the standard assessment, while testing the hypothesis using t test Dependent analysis. Result : Based on the result of statistical test, the mechanism of cooperative schizophrenia client cooperate in outpatient care in health center of Puskesmas Karanganyar Gandusari District Trenggalek mean difference of therapy of prayer in Islam before therapy and after therapy is 0,400 with standard deviation 0,503. Beside that got value p value = 0,002. Conclusion :The results of this study indicate there is a significant difference between before prayer therapy and after therapy do'a to coping mechanism of client of schizophrenia

Background: Research in natural substances for their anticancer potential has become increasingly popular. Lunasin, a soybean protein, is known to inhibit cancer progression via various pathways. The aim of this study was to investigate the effect of Lunasin Extract (LE) on the expression of Intercellular Adhesion Molecule 1 (ICAM-1) and epithelial cadherins (E-Cadherin) in breast cancer. Methods: In this true-experimental in vivo study, 24 Sprague-Dawley rats that were induced by 7,12-Dimethylbenz[a]anthracene (DMBA), were used. Based on the therapy given, the groups were divided into, normal, positive control (PC), negative control (NC), adjuvant, curative, and preventive. Lunasin was extracted from soybean seeds of the Grobogan variety in Indonesia. Tissue samples were obtained, processed, stained with anti-ICAM-1 and anti-E-Cadherin antibodies, examined under a microscope, and quantified using H-score. The data were analyzed using ANOVA, which was then followed by Duncan's test. Results: Statistically significant difference in ICAM-1 expression was observed between the following groups: adjuvant and NC, normal and NC, PC and NC, adjuvant and preventive, normal and preventive, PC and preventive, adjuvant and curative, normal and curative, PC and curative. E-Cadherin expression was significantly different between preventive and NC, adjuvant and NC, PC and NC, normal and NC, adjuvant and curative, PC and curative, normal and curative, normal and preventive. Significant negative correlation was found between ICAM-1 and E-Cadherin [-0.616 (-0.8165; -0.283)] with p = 0.001. Conclusion: Preventive dose of LE was able to reduce ICAM-1 expression while increasing E-Cadherin expression.

INTRODUCTION AND OBJECTIVE:The feasibility of ultrasonic propulsion and burst wave lithotripsy (BWL) to noninvasively reposition distal ureteral stones to facilitate passage and relieve pain was te...

Background: Research in natural substances for their anticancer potential has become increasingly popular. Lunasin, a soybean protein, is known to inhibit cancer progression via various pathways. The aim of this study was to investigate the effect of Lunasin Extract (LE) on the expression of Intercellular Adhesion Molecule 1 (ICAM-1) and epithelial cadherins (E-Cadherin) in breast cancer. Methods: In this true-experimental in vivo study, 24 Sprague-Dawley rats that were induced by 7,12-Dimethylbenz[a]anthracene (DMBA), were used. Based on the therapy given, the groups were divided into, normal, positive control (PC), negative control (NC), adjuvant, curative, and preventive. Lunasin was extracted from soybean seeds of the Grobogan variety in Indonesia. Tissue samples were obtained, processed, stained with anti-ICAM-1 and anti-E-Cadherin antibodies, examined under a microscope, and quantified using H-score. The data were analyzed using ANOVA, which was then followed by Duncan's test. Results: Statistically significant difference in ICAM-1 expression was observed between the following groups: adjuvant and NC, normal and NC, PC and NC, adjuvant and preventive, normal and preventive, PC and preventive, adjuvant and curative, normal and curative, PC and curative. E-Cadherin expression was significantly different between preventive and NC, adjuvant and NC, PC and NC, normal and NC, adjuvant and curative, PC and curative, normal and curative, normal and preventive. Significant negative correlation was found between ICAM-1 and E-Cadherin [-0.616 (-0.8165; -0.283)] with p = 0.001. Conclusion: Preventive dose of LE was able to reduce ICAM-1 expression while increasing E-Cadherin expression.

INTRODUCTION AND OBJECTIVE:We report stone comminution in the first human subjects by burst wave lithotripsy (BWL), which is the transcutaneous application of focused, cyclic ultrasound pulses.METH...

Air pollution has become a growing concern, especially in urban cities with rapidly developing economies, increasing infrastructure and vehicular population, and reduced green spaces. Fossil fuel and transportation are the main source of pollutive particles (e.g., sulfur oxide and nitrous) released into the atmosphere. Once they have entered the atmosphere, these particles create health problems, degrade air quality, and cause acid rain. Seasonal investigations on rainwater chemistry and particulate matter pollution (SPM, PM10, and PM2.5) were conducted to understand the recent state of the ambient air quality in Jakarta, Indonesia. The characteristics of PM2.5 were also analyzed during Ied Al Fitr in 2016 and 2017. Based on the observational data, the ambient air quality in Jakarta improved during the period of our study (2000–2016). The chemical constituents, i.e., the anion and cation concentrations, in precipitation show decreasing trends starting from 2006. Moreover, the PM10 and SPM concentrations also decreased slightly. The causes of these favorable trends are climatic conditions—namely, an increasing trend of rainfall—and policy intervention. Additionally, an assessment during the feast of Ied Al Fitr in 2016 and 2017 indicated a further decrease in PM2.5 due to highly reduced inner-city traffic. These events exhibited an extreme reduction of the PM2.5 concentration in Jakarta.

Based on the phenomenon occurred at all level of education, it was found that the circumstances of the schools were unsafe and uncomfortable for students and academics. There were a number of direct and indirect violence carried out at schools and it had impacts on physical and psychological health of students. There was no existence of positive peace in the form of structural violence, socio-cultural violence, ecological violence and negative peace such as tribal warfare, fights and aggression. What happened actually although the nature of man in conscience had the basic harmony and desire to live together in tranquility? Therefore, the common perception of the concept of peace and peace pedagogy was needed to be created. Teachers as peace educators, thus, played an important role as a figure that had the personality of peace in the classroom and at school. The teacher as a peaceful personality consisted of three components: peaceful states, attitudes, and behavior that were consistent across one’s life spaces and life span. Moreover, the school also needed to develop an educational approach in the curriculum in synergy with the goals of education.

Rokok merupakan sumber radikal bebas yang dapat menyebabkan stress oksidatif dandapat merusak fungsi organ-organ penting dalam tubuh diantaranya organ hati yang ditandaidengan peningkatan kadar SGPT dan SGOT. Penelitian bertujuan mengetahui aktivitas ekstraketanol 70% daun kemuning (Murraya paniculata (L.) Jack) terhadap penurunan kadar SGPTdan SGOT pada tikus yang dipapar asap rokok.Penelitian ini bersifat eksperimental menggunakan 25 tikus yang dibagi menjadi 5kelompok yaitu kontrol normal(Ko), kontrol negative(Kn), dan 3 kelompok perlakuan yang diberiekstrak etanol 70% daun kemuning dengan dosis 100 mg/KgBB (K1), 200 mg/KgBB (K2), dan400 mg/KgBB (K3). Data kadar SGPT dan SGOT dianalisis dengan ANOVA satu arah dan ujiTukey.Hasil ANOVA satu arah menunjukkan terdapat pengaruh perlakuan terhadap kontrol (p< 0,05). Hasil uji Tukey dapat dilihat bahwa kadar SGPT pada dosis II dan III berbedabermakna dengan kontrol negatif dan tidak berbeda bermakna dengan kontrol normal denganhasil kadar sebesar 34,6 U/L (dosis II) dan 14,4 U/L (dosis III). Pada kadar SGOT semuakelompok perlakuan menunjukkan hasil berbeda bermakna dengan kontrol negatif dan tidakberbeda bermakna dengan kontrol normal dengan nilai sebesar 193,6 U/L (dosis I), 191,4 U/L(dosis II), 156,6 U/L (dosis III). Dari hasil penelitian dapat disimpulkan bahwa ekstrak etanol70% daun kemuning memiliki aktivitas sebagai hepatoprotektor.

Objective: to determine the patient’s characteristics, correlation between staging and chemotherapy response, furthermore two years overall survival rate. Methods: a retrospective analytic study was conducted. Data were obtained from medical records in January 2008 to December 2014 and analyzed using SPSS 17.0. All of correlation between staging and chemotherapy response, primary tumor staging (pT) and metastasis (M), regional lymph nodes staging (N) and metastasis (M), serum tumor marker and chemotherapy response were tested by Spearman correlation test. Two years overall survival rate was analyzed by Kaplan-Meier. Data ratio with normal distribution was tested by Paired T-test. Results: the mean age of patients were 31.03 ± 13.751 years, with seven patients (15.6%) had previous history of undescended testis. Based on TNM staging, we found that most patients had already develop into stage pT3 (46.7%), N3 (57.7%), and M0 (57.7%). A significant correlation between staging and chemotherapy response was shown with stage I of testicular seminoma had completely chemotherapy response (100%) and two years overall survival rate in stage I was 100%, whereas in metastatic seminoma (stage II and III) was 60%, with Hazard Ratio 0.63 (p=0.294; 95%CI 0.276-1.476). Conclusion: patients in early stage of testicular seminoma will give a better response to chemotherapy and will have better survival rate compared to those with metastatic seminoma.

The purpose of this study was to find a method of determining laser models and intra vaginal progesteronesponge in Bali Cattle. An assessment was carried out at Sapi Loka Grati, Pasuruan, Indonesia. The parametersobserved included the symptoms of estrus, response of estrus, and the level of pregnancy. Twenty Balinesecows were divided at random in two groups. P1 treated with laser puncture at a certain point and P2 treatedwith 1.5 g of progesterone + 10 mg of estradiol benzoate intra vaginal sponge. The diagnosis of subsequentpregnancies was done by ultrasonographic examination on day 40th after artificial insemination (AI). Thelaser used in this study was a soft laser with power supply specifications as follows: 50 Hz, 220 Volts, 50Watts, ranging from 0.2 Joules to 0.5 Joules. These lasers include semiconductor lasers and laser probes.Three acupuncture points were used (GV 4, BL-22, and GV-2). Furthermore, the intra vaginal progesteronesponge used was made from silicone plastic similar to the drugs containing medroxyprogesterone acetate.Data testing was done by using the T-test. Results demonstrated that the P1 responses of estrus appeared onday 3rd, while P2 on day 9th. There was no significant difference (p >0.05) in the accumulation of estrus andpregnancy. In conclusion, estrus synchronization and pregnancy rate could be efficiently achieved in Balicattle using either laser puncture or intra vaginal progesterone sponge. However, laser puncture treatmentinduced more spread estrus with higher pregnancy rate.

Culex quinquefasciatus is the main vector of lymphatic filariasis in Pekalongan City. Sterile Insect Tehnique (SIT) could be complementary vector control for filariasis. The key success of the technique depend on the ability of laboratory-reared sterile males with the wild-type females.The aim of the research was to determine the mating competitiveness, the fecundity and the fertility of sterile male Culex quinquefasciatus. The pupae of Cx. quinquefasciatus were gamma irradiated at the doses of 60Gy, 70Gy, and 80Gy, while unirradiated pupae were prepared as control. The mosquitoes emerging from the irradiated pupae could mate with a normal female in the cages. It were observed for the mean female laying eggs, the fecundity, the fertility and the mating competitiveness. The data were analyzed by one way ANOVA. The result showed that the irradiated Cx. quinquefasciatus at the doses tested did not affect on the fecundity and the mating competitiveness, but the fertility was disturbed (sterile). A dose of 70 Gy was the optimum dose or a fertility rate of 1.8% (98.2% sterile), and the value of competitiveness (C index) was 0.568. Based on the result, the irradiated Cx. quinquefasciatus can be recommended for semifield application.

Colibacillosis in Indonesia until now still appears frequently, so the case of colibacillosis laying hens cannot reach the peak of egg production; the egg production period is delayed and easily infected with other diseases. The purpose of this research is that the acidifier-dextrose combination is expected to be able to suppress the development of Avian Pathogenic Escherichia coli (APEC) bacteria in laying hens so that, in the end, the case of colibacillosis can be controlled in Indonesia. A total of 240 heads of laying hens were divided into 6 treatments and each consisted of 40 replications. The results of this research state that a combination of acidifier-dextrose can increase Hen Day Production ( p < 0.05 ) and decrease Feed Conversion Ratio ( p < 0.05 ) in laying hens infected with APEC. The Hen Day Production results of the treatment group infected with APEC showed the lowest results, amounting to 65.75% whereas the other treatments are still above 90%. Furthermore, the highest Feed Conversion Ratio results were on treatments infected with APEC, which amounted to 2.17 while other treatments of the Feed Conversion Ratio results are still below 1.80. In general, the use of a combination of acidifier and dextrose with the lowest dose, that is, 1 g/3.75 liters of drinking water can still give good results to Hen Day Production and Feed Conversion Ratio for laying hens infected with APEC. Giving combination of acidifier-dextrose can increase Hen Day Production and decrease Feed Conversion Ratio in laying hens infected with APEC. The recommended dosage of acidifier-dextrose combination in laying hens based on this research is 1 g/3.75 liters of drinking water.

Relative deficiencies develop in two types of society: poor (deprived) and disadvantaged (unfortunate), little research for this arrangement has been conducted in the field of education. This will discuss the relative deprivation character of underprivileged children in the realm of education. This research uses a descriptive method. The descriptive survey was used to describe the relative character of deprivation among underprivileged children at school, knowing the differences between boys and girls. The subjects in this study were grade 5 and grade 6 elementary school students in the Bekasi area with a total of 77 students: 37 boys and 40 girls. The instrument used in this study is an instrument that has been tested by experts, validity and reliability. It uses a relative deprivation scale for disadvantaged children. The data were analyzed descriptively by describing the minimum and maximum scores of each item, thus showing strength of each characteristic. In addition, the frequency score also described to highlight differences in the relative characteristics of deprivation among male and female students. The results explained that the participants had a very strong deprivation character, males were more dominant than females. The strongest characters reflected their lesser curiosity about things, but the girls exhibit better score related to rule obedience. The results of this study could be used as a reference to treat students' relative deficiencies through guidance and counseling services.

The beef cattle breeding business in Kedungrejo village, Kedungadem sub-district, Bojonegoro Regency in general has not implemented an efficient business concept considering that there are many potentials and opportunities that have not been utilized and managed optimally, especially those related to livestock reproduction and beef cattle production. Constraints that are often encountered are the low success rate of Artificial Insemination (IB) of beef cattle because poor quality cement and inseminator skills are not sufficient. Such conditions are also an illustration of the Beef Cattle Breeders in Kedungrejo Village, Kedungadem District, Bojonegoro Regency. Kedungrejo village was chosen to be a place for cattle development on dry land because it has the potential to breed cattle crosses of Lemosin and Simental cattle which produce good meat. The development of cattle in Kedungrejo village, Kedungadem sub-district, aims to increase economic activities in support of cattle reproduction intensification efforts to increase people’s cattle farming. This activity for the community aims to fulfill meat self-sufficiency through the introduction, dissemination, transfer of reproductive technology by artificial insemination using Limousine and Simental sperm crosses. Beef cattle farmers in Kedungrejo Village Kedungadem Bojonegoro Subdistrict have the prospect of beef cattle breeding which can be developed to fulfill meat self-sufficiency that is being promoted. Specific targets of outcomes to be achieved include the success of insemination, increased birth rate, improvement of genetic quality of beef cattle through Artificial Insemination using Limousine and Simental sperm crosses in the Kedungrejo Village, Kedungadem Bojonegoro District. The method used in achieving this goal by socializing Artificial Insemination using Limousine and Simental Sperm Crosses. The solution offered is through the coaching, training and application stages. The results of community service activities indicate that Artificial Insemination using Limousine and Simental Sperm Crosses has the prospect of being developed as an increase in the success of insemination, increased birth rate, genetic quality improvement has a positive influence on beef reproductive and meat self-sufficiency. Abstrak Usaha peternakan sapi potong di desa Kedungrejo Kecamatan Kedungadem Kabupaten Bojonegoro pada umumnya belum menerapkan konsep usaha yang efi sien mengingat banyak potensi dan peluang yang belum dimanfaatkan dan dikelola secara optimal terutama yang terkait reproduksi ternak dan produksi ternak sapi potong. Kendala yang sering dijumpai adalah rendahnya tingkat keberhasilan Inseminasi Buatan (IB) ternak sapi potong karena kualitas semen yang kurang baik dan skill inseminator belum memadai. Kondisi demikian juga merupakan gambaran dari Peternak Sapi Potong Desa Kedungrejo Kecamatan Kedungadem Kabupaten Bojonegoro. Desa Kedungrejo dipilih menjadi tempat pengembangan ternak sapi di lahan kering karena mempunyai potensi untuk pemuliabiakan persilangan sapi Lemosin dan sapi Simental yang menghasilkan daging yang bagus. Pengembangan ternak sapi di desa Kedungrejo Kecamatan Kedungadem bertujuan meningkatkan kegiatan perekonomian dalam mendukung usaha intensifi kasi reproduksi sapi untuk peningkatan peternakan sapi rakyat. Kegiatan kepada masyarakat ini bertujuan pemenuhan swasembada daging melalui pengenalan, penyebarluasan, alih teknologi reproduksi dengan cara Inseminasi buatan menggunakan persilangan sperma Limousin dan Simental. Peternak sapi potong Desa Kedungrejo Kecamatan Kedungadem Bojonegoro mempunyai prospek peternakan sapi potong yang dapat dikembangkan untuk memenuhi swasembada daging yang sedang digalakkan. Target khusus luaran yang ingin dicapai berupa keberhasilan inseminasi, peningkatan angka kelahiran, perbaikan mutu genetik sapi potong melalui Inseminasi Buatan menggunakan persilangan sperma Limousin dan Simental di wilayah Desa Kedungrejo Kecamatan Kedungadem Bojonegoro. Metode yang dipakai dalam pencapaian tujuan tersebut dengan sosialisasi Inseminasi Buatan menggunakan Persilangan Sperma Limousin dan Simental. Solusi yang ditawarkan adalah melalui tahap pembinaan, pelatihan dan aplikasi. Hasil kegiatan pengabdian kepada masyarakat ini menunjukkan bahwa Inseminasi Buatan menggunakan Persilangan Sperma Limousin dan Simental mempunyai prospek untuk dikembangkan sebagai peingkatan keberhasilan inseminasi, peningkatan angka kelahiran, perbaikan mutu genetik memberi pengaruh positif terhadap reproduktivitas sapi potong dan pemenuhan swasembada daging.

Background: Accuracy of preoperative brain tumor’s histopathologic differentiation is very important to determine preoperative staging, intraoperative management and postoperative therapy. Diffusion weighted magnetic resonance imaging is an advanced technique developed as an important method for brain tumor assessment. Objectives: This study aimed to investigate correlation between diffusion weighted imaging (DWI) profile and apparent diffusion coefficient (ADC) value with brain tumor’s histopathology. Methods: This study examined 86 subjects with brain tumors using magnetic resonance imaging and histopathology examination at Dr. Soetomo Teaching Hospital and evaluated DWI profile and ADC maps. The spherical ROI on ADC maps was placed on the solid part of the tumor to measure ADC value. Spearman’s correlation test was conducted to determine correlation between DWI profile and ADC values with histopathological grading and types of brain tumor. Results: There was a significant correlation between DWI profile and ADC values (p = 0.000), as well as DWI and ADC values with histopathological grading and types of brain tumor (p = 0.000). There was an inverse corelation between ADC value and histopathological grading. The higher the ADC value, the lower the brain tumor grade, while lower ADC value resulted in high tumor grade. The average ADC value of grade-1 meningiomas was 1.061±0.257 x 10-3 mm2/sec, pilocytic astrocytoma was 1.301±0.107 x 10-3 mm2/ sec, glioblastoma multiforme was 0.831±0.080 x 10-3 mm2/sec, and medulloblastomas was 0.600±0.078 x 10-3 mm2/sec. Conclusion: Evaluation on DWI profile and ADC value could provide additional information on conventional magnetic resonance imaging examination to determine histopathological grading and types of both intra and extra-axial brain tumors.

INTRODUCTION AND OBJECTIVE:Medical malpractice (MP) is an important issue in our country. There has been controversy surrounding PSA testing and prostate cancer screening, specifically the United S...