Author: "Vittorio Romano" / Topic: medicine - Searchworks@Jio Institute Digital Library Search Results

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1. TAVR in Bicuspid Valve With Pure Aortic Regurgitation

Author: Luca A. Ferri, RT Vittorio Romano, Matteo Montorfano, Gianmarco Iannopollo, Filippo Russo, Francesco Melillo, Nicola Buzzatti, Marco Ancona, Barbara Bellini, and Ciro Vella
Subjects: medicine.medical_specialty, business.industry, Bicuspid valve, medicine.medical_treatment, Internal medicine, medicine, Cardiology, Lira, Regurgitation (circulation), Cardiology and Cardiovascular Medicine, business, Prosthesis, Sizing
Published: 2021

2. Supra-annular sizing of transcatheter aortic valve prostheses in raphe-type bicuspid aortic valve disease: the LIRA method

Author: Juan F. Granada, Barbara Bellini, Nicola Buzzatti, Marco Ancona, Vittorio Romano, Filippo Russo, Alaide Chieffo, Luca A. Ferri, Matteo Montorfano, and Gianmarco Iannopollo
Subjects: Male, medicine.medical_specialty, Transcatheter aortic, medicine.medical_treatment, Heart Valve Diseases, Lira, 030204 cardiovascular system & hematology, Prosthesis Design, Prosthesis, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Bicuspid aortic valve, Patient age, Internal medicine, Multidetector Computed Tomography, medicine, Humans, 030212 general & internal medicine, Paravalvular leak, Heart valve, Aged, Aged, 80 and over, business.industry, Aortic Valve Stenosis, medicine.disease, Aortic Valve Disease, Sizing, Treatment Outcome, medicine.anatomical_structure, Aortic Valve, Heart Valve Prosthesis, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Background Recent evidence shows that THV prostheses anchoring occurs at the raphe-level, known as LIRA plane, in raphe-type bicuspid aortic valve (BAV) disease. The purpose of this study was to evaluate the application of a novel supra-annular sizing method, known as Level of Implantation at the RAphe (LIRA) method, to optimize transcatheter heart valve (THV) prosthesis sizing in raphe-type BAV disease. Methods and results The LIRA method was applied to all consecutive patients with raphe-type BAV disease between November 2018 to January 2020 in our centre. THV prostheses were sized on the basis of baseline CT scan perimeters at the LIRA plane and at the virtual basal ring. In case of discrepancy between the two plane measurements, the plane with the smallest perimeter was considered the reference for prosthesis sizing. Post-procedural device success, defined according to Valve Academic Research Consortium–2 (VARC-2) criteria, was evaluated in the overall cohort. 20 patients (mean patient age 81 ± 5.4 years, 70% males) were identified as having a raphe-type BAV disease at pre-procedural CT scans and were implanted with different types of THV prostheses. The LIRA plane method appeared to be highly successful (100% VARC-2 device success) with no procedural mortality, no valve migration, no moderate-severe paravalvular leak and low transprosthetic gradient (residual mean gradient of 8.2 ± 2.9 mm Hg). Conclusions Supra-annular sizing according to the LIRA method appeared to be safe with a high device success. The application of the LIRA method might optimize THV prosthesis sizing in patients with raphe-type BAV disease.
Published: 2020

3. Odd Residual Regurgitation After Mitral Valve-in-Ring

Author: Marco Ancona, Matteo Montorfano, RT Vittorio Romano, Nicola Buzzatti, Alessandro Castiglioni, Stefano Stella, Eustachio Agricola, Michele De Bonis, and Alessandra Sala
Subjects: medicine.medical_specialty, Mitral regurgitation, business.industry, medicine.medical_treatment, Regurgitation (circulation), 030204 cardiovascular system & hematology, Valve in ring, Ring (chemistry), Prosthesis, Seal (mechanical), Surgery, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Mitral valve, Medicine, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business
Abstract: Undersized rigid rings represent an unfavorable anatomy for valve-in-ring (ViR) procedures due to the high chances that the transcatheter prosthesis cannot fully expand to seal the commissures, remaining deformed at the same time. A 76-year-old woman with recurrent secondary mitral regurgitation (
Published: 2020

4. Coronary Access After Repeated Transcatheter Aortic Valve Implantation

Author: Béla Merkely, Michele De Bonis, Liesbeth Rosseel, Matteo Montorfano, Nicola Buzzatti, Azeem Latib, Lars Soendergaard, Bernard Prendergast, Stefania Ruggeri, Pál Maurovich-Horvat, Antonio Colombo, Júlia Karády, Vittorio Romano, and Ole De Backer
Subjects: medicine.medical_specialty, Transcatheter aortic, business.industry, medicine, MEDLINE, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business, Valve in valve, Surgery
Published: 2020

5. First‐in‐man Valve‐in‐Valve with the new balloon‐expandable Myval transcatheter heart valve in a failed sutureless Perceval bioprosthesis

Author: Nicola Buzzatti, Igor Belluschi, Vittorio Romano, Michele De Bonis, Ottavio Alfieri, Paolo Denti, Matteo Montorfano, Mattia Glauber, Antonio Miceli, Alessandro Castiglioni, Belluschi, I., Buzzatti, N., Denti, P., Romano, V., Miceli, A., Alfieri, O., De Bonis, M., Glauber, M., Castiglioni, A., and Montorfano, M.
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Percutaneous, medicine.medical_treatment, Myval, 030204 cardiovascular system & hematology, Prosthesis Design, Prosthesis, 03 medical and health sciences, 0302 clinical medicine, Older patients, medicine, Humans, Heart valve, Valve-in-Valve, Aged, Bioprosthesis, Heart Valve Prosthesis Implantation, Perceval, business.industry, Aortic Valve Stenosis, Sutureless Surgical Procedures, Valve in valve, Surgery, Treatment Outcome, Balloon expandable stent, medicine.anatomical_structure, 030228 respiratory system, Aortic Valve, Heart Valve Prosthesis, Cardiology and Cardiovascular Medicine, business
Abstract: Sutureless aortic bioprostheses were introduced more than ten years ago, with the aim of decreasing cross-clamp time and thus becoming the first choice in older patients for many surgeons. However, published data are limited to a 5-year follow-up, and some cases of deterioration have already been described. High-risk patients who once have benefitted from a fast sutureless aortic replacement and now are experiencing a prosthesis dysfunction, could take advantage of a percutaneous Valve-in-Sutureless technique. Furthermore, thanks to technological improvement, new transcatheter prostheses have been designed, allowing a more precise positioning. In this report, we described the first Myval-in-Perceval case, which resulted in a safe and effective procedure.
Published: 2021

6. Patients younger than 70 undergoing transcatheter aortic valve implantation: Procedural outcomes and mid-term survival

Author: Eustachio Agricola, Caterina Mula, Marco Ancona, Barbara Bellini, Filippo Russo, Igor Belluschi, Vittorio Romano, Nicola Buzzatti, Matteo Montorfano, Antonio Sorropago, Francesco Moroni, Alessandro Beneduce, Evelina Toscano, Costanza Festorazzi, Marco Gamardella, Luca A. Ferri, Ciro Vella, Ancona, Marco B, Toscano, Evelina, Moroni, Francesco, Ferri, Luca A, Russo, Filippo, Bellini, Barbara, Sorropago, Antonio, Mula, Caterina, Festorazzi, Costanza, Gamardella, Marco, Vella, Ciro, Beneduce, Alessandro, Romano, Vittorio, Belluschi, Igor, Buzzatti, Nicola, Agricola, Eustachio, and Montorfano, Matteo
Subjects: medicine.medical_specialty, Transcatheter aortic, Long term durability, medicine.medical_treatment, THV, transcatheter heart valve, Population, 030204 cardiovascular system & hematology, SAVR, surgical aortic valve replacement, Prosthesis, 03 medical and health sciences, Liver disease, BEV, balloon expandable valve, 0302 clinical medicine, Medicine, Diseases of the circulatory (Cardiovascular) system, 030212 general & internal medicine, education, Transcatheter heart valve, education.field_of_study, Original Paper, Transcatheter aortic valve implantation, business.industry, CABG, coronary artery bypass graft, High risk, Incidence (epidemiology), Aortic stenosis, SEV, self expandable valve, Retrospective cohort study, medicine.disease, Surgery, Stenosis, Young population, RC666-701, TAVI, transcatheter aortic valve implantation, Cardiology and Cardiovascular Medicine, business
Abstract: Introduction Based on recent data, the indication for transcatheter aortic valve implantation (TAVI) is expanding to individuals at lower surgical risk, who are generally younger than subjects historically treated for severe aortic stenosis. Indeed, younger patients have traditionally been under-represented in current TAVI literature. The aim of the present study is to report about clinical features, procedural outcomes and mid-term outcomes of patients younger than 70 who underwent TAVI in a single high-volume center. Materials and methods Consecutive patients younger than 70 years of age who underwent TAVI for severe, symptomatic aortic stenosis between 2007 and 2019 at a single, tertiary referral center have been included in this retrospective study. Procedural and mid-term outcomes were analyzed, comparing 1st generation with 2nd generation devices. Results Between 2007 and 2019, 1740 TAVI procedures were performed in our center. Among these, one hundred twenty-nine (7.4%) patients were younger than 70 years at the time of the intervention and were included in the present analysis. Fifty-eight patients (45%) were implanted with a 1st generation prosthesis while seventy-one patients (55%) were implanted with a 2nd generation device. Reasons which lead to a transcatheter approach in this population were: previous CABG (27.9%); porcelain aorta (24%); severe left ventricular systolic dysfunction (21.7%); prior chest radiation (19.4%); severe lung disease (8.5%); hemodynamic instability (7.0%); advanced liver disease (4.6%) and active cancer (3.9%). Overall device success rate was 89%, with no differences among 1st and 2nd generation devices. Threeyears all-cause mortality was 34%, with no difference among the two groups. Low incidence of aortic-valve re-intervention was observed at mid-term follow-up (late valve re-intervention = 2.3%). Conclusions TAVI in young patient with appropriate indication for intervention is a safe procedure, associated with low rate of in hospital mortality and low rate of severe complications both with 1st and with 2nd generation devices. When considering long term durability, more data are needed; in our case series long-term follow up shows a good survival and also an extremely low rate of valve re-intervention.
Published: 2021

7. A novel supra-annular plane to predict TAVI prosthesis anchoring in raphe-type bicuspid aortic valve disease: the LIRA plane

Author: Vittorio Romano, Lars Søndergaard, Nicola Buzzatti, Bernard Prendergast, Francesco Giannini, Juan F. Granada, Antonio Colombo, Azeem Latib, Ole De Backer, Alaide Chieffo, Matteo Montorfano, Gianmarco Iannopollo, and Béla Merkely
Subjects: Heart Valve Prosthesis Implantation, Raphe, Plane (geometry), business.industry, medicine.medical_treatment, Heart Valve Diseases, Anchoring, Aortic Valve Stenosis, Prostheses and Implants, Anatomy, Prosthesis Design, medicine.disease, Prosthesis, Bicuspid aortic valve, Bicuspid Aortic Valve Disease, Aortic Valve, Heart Valve Prosthesis, medicine, Humans, Cardiology and Cardiovascular Medicine, business
Published: 2020

8. Sex and Transcatheter Aortic Valve Implantation: Impact of Female Sex on Clinical Outcomes

Author: Alaide Chieffo, Vittorio Romano, Barbara Bellini, Alessandra Laricchia, Matteo Montorfano, and Saud Khawaja
Subjects: medicine.medical_specialty, Ejection fraction, RD1-811, Transcatheter aortic, business.industry, Female sex, medicine.disease, Transcatheter aortic valve replacement, Alternative treatment, Stenosis, Structural, RC666-701, Internal medicine, medicine, Cardiology, Diseases of the circulatory (Cardiovascular) system, Surgery, In patient, High surgical risk, women, Cardiology and Cardiovascular Medicine, Symptomatic aortic stenosis, business
Abstract: Transcatheter aortic valve implantation (TAVI) has emerged as an alternative treatment for severe symptomatic aortic stenosis in patients who are not suitable for surgery or are at high surgical risk. Approximately 50% of patients undergoing TAVI are female and this is reflected by a higher inclusion rate of women in TAVI trials. However, women undergoing TAVI have different baseline clinical characteristics in comparison to men, with fewer comorbidities and a more preserved left ventricular ejection fraction. This translates into favourable outcomes after TAVI, despite a higher rate of peri-procedural complications. This article discusses gender differences in terms of presentation, procedural characteristics and post-procedural results in patients with aortic stenosis undergoing TAVI, with particular focus on possible sex-specific factors affecting outcome.
Published: 2019

9. Systematic Fluoroscopic-Echocardiographic Fusion Imaging Protocol for Transcatheter Edge-to-Edge Mitral Valve Repair Intraprocedural Monitoring

Author: Matteo Montorfano, Francesco Ancona, Stefano Stella, Eustachio Agricola, Cosmo Godino, Davide Maccagni, Giacomo Ingallina, Antonio Colombo, Azeem Latib, Vittorio Romano, Francesco Melillo, Andrea Fisicaro, Stefania Ruggeri, Cristina Capogrosso, Melillo, F., Fisicaro, A., Stella, S., Ancona, F., Capogrosso, C., Ingallina, G., Maccagni, D., Romano, V., Ruggeri, S., Godino, C., Latib, A., Montorfano, M., Colombo, A., and Agricola, E.
Subjects: medicine.medical_specialty, Percutaneous mitral valve repair, medicine.medical_treatment, Population, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine, Fluoroscopy, Humans, Radiology, Nuclear Medicine and imaging, education, Heart Valve Prosthesis Implantation, Mitral valve repair, Mitral regurgitation, Percutaneous repair, education.field_of_study, 3D echocardiography, medicine.diagnostic_test, business.industry, MitraClip, Mitral Valve Insufficiency, Odds ratio, Fusion imaging, Echocardiography, Mitral Valve, Radiology, Cardiology and Cardiovascular Medicine, business, Percutaneous Mitral Valve Repair
Abstract: Background Whether fluoroscopic-echocardiographic fusion imaging (FI) might offer added value for intraprocedural guidance during transcatheter edge-to-edge mitral valve repair is yet unknown, and few data exist regarding the safety and feasibility of this novel technology. Methods The aim of this single-center study was to test and validate a FI protocol for intraprocedural monitoring of transcatheter edge-to-edge mitral valve repair and assess its clinical usefulness. Eighty patients underwent MitraClip implantation using FI guidance (FI+) for either degenerative (35%) or functional (65%) mitral regurgitation and were compared with the last 80 patients before FI introduction, treated using conventional echocardiography and fluoroscopic monitoring (FI−). Results The number of patients treated for functional and degenerative mitral regurgitation was similar between the FI+ and FI− groups, as well as the number of devices implanted (1.51 ± 0.5 vs 1.58 ± 0.6, P = .46). The prevalence of complex mitral anatomy for percutaneous repair was high (32.5%, up to 39.2% in the hybrid arm). Fluoroscopy time was significantly lower in FI+ patients (37.3 ± 14.6 vs 48.3 ± 28.3 min, P = .003), but not kerma area product (91.5 ± 74.1 vs 108.8 ± 105.0 Gy · cm2, P = .23) or procedural time (92.2 ± 36.1 vs 103.1 ± 42.7 min, P = .086). After adjusting for confounding factors (MitraClip XT device and complex anatomy), FI reduced fluoroscopy time (coefficient = −10.4 min; 95% CI, −18.03 to −2.82; P = .007) and improved procedural success at the end of the procedure (odds ratio, 2.87; 95% CI, 1.00 to 8.24; P = .049) and discharge (odds ratio, 2.24; 95% CI, 1.04 to 4.80; P = .039). Rates of periprocedural complications were similar in both groups (8.9% vs 13.0%, P = .40). Conclusions The authors describe the systematic use of an FI protocol for intraprocedural guidance during transcatheter edge-to-edge mitral valve repair, demonstrating a reduction in fluoroscopy time and an improvement in procedural success in a population with a high prevalence of challenging mitral anatomy for percutaneous repair.
Published: 2021

10. Self-expanding transcatheter aortic valve infolding: Current evidence, diagnosis, and management

Author: Barbara Bellini, Alaide Chieffo, Nicola Buzzatti, Marco Ancona, Eustachio Agricola, Vittorio Romano, Giovanni Landoni, Filippo Russo, Matteo Montorfano, Alessandro Beneduce, Luca A. Ferri, Anna Mara Scandroglio, Ancona, Marco Bruno, Beneduce, Alessandro, Romano, Vittorio, Buzzatti, Nicola, Russo, Filippo, Bellini, Barbara, Ferri, Luca Angelo, Agricola, Eustachio, Landoni, Giovanni, Scandroglio, Anna Mara, Chieffo, Alaide, and Montorfano, Matteo
Subjects: medicine.medical_specialty, Transcatheter aortic, medicine.medical_treatment, 030204 cardiovascular system & hematology, Prosthesis Design, Prosthesis, self-expanding transcatheter heart valve, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Bicuspid aortic valve, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Stroke, transcatheter aortic valve implantation, Severe complication, Retrospective Studies, business.industry, General Medicine, Aortic Valve Stenosis, medicine.disease, Surgery, Treatment Outcome, Native valve, Aortic Valve, Heart Valve Prosthesis, Cardiology and Cardiovascular Medicine, Complication, business, Calcification
Abstract: Background Prosthetic valve infolding is a rare but severe complication of transcatheter aortic valve implantation (TAVI) with self-expanding valves. However, currently available clinical data are limited and fragmented. Objectives This report aims to provide a comprehensive overview of this complication focusing on predisposing factors, clinical presentation, diagnostic findings, treatment and clinical outcomes. Methods A systematic review of the literature was performed to identify cases of infolding occurring during TAVI with self-expanding valves published until August 2020. These data were pooled with all the retrospectively identified infolding cases occurred at San Raffaele Scientific Institute between December 2014 and August 2020. Results A total of 34 cases were included. Among patients with available data, 38% received a first-generation CoreValve, and 62% a second-generation Evolut R (82%) or Evolut PRO (18%). Infolding occurred mostly with ≥29-mm valves (94%). Predisposing factors included resheathing of a second-generation valve (82%), heavy calcification of the native valve (65%), lack of predilatation (16%), Sievers type-1 bicuspid aortic valve (11%), and improper valve loading (5%). Infolding resulted in severe PVL causing hemodynamic instability (29%) or cardiac arrest (12%). Postdilatation was the treatment strategy in 68%, while prosthesis replacement with a new device in 23% of cases. Device success rate was 82%. Death and stroke occurred in 3% and 12% of cases. Conclusions Prosthetic valve infolding is typically observed after resheathing of a large-size self-expanding TAVI. When infolding is timely diagnosed, prosthesis removal and replacement should be pursued. Further studies are required to precisely define predisposing factors to prevent this complication.
Published: 2020

11. Percutaneous exclusion of left ventricular pseudoaneurysm

Author: Alessandro Beneduce, Luca A. Ferri, Davide Vignale, Barbara Bellini, Filippo Russo, Alaide Chieffo, Ciro Vella, Francesco Ancona, Vittorio Romano, Matteo Montorfano, Eustachio Agricola, Antonio Esposito, Emanuele Visco, Marco Ancona, Ancona, Marco B, Visco, Emanuele, Bellini, Barbara, Romano, Vittorio, Vella, Ciro, Ferri, Luca, Russo, Filippo, Beneduce, Alessandro, Ancona, Francesco, Vignale, Davide, Esposito, Antonio, Chieffo, Alaide, Agricola, Eustachio, and Montorfano, Matteo
Subjects: Aged, 80 and over, Male, medicine.medical_specialty, Cardiac Catheterization, Percutaneous, business.industry, Left ventricular pseudoaneurysm, MEDLINE, General Medicine, Administration, Cutaneous, Surgery, Ventricular Dysfunction, Left, Treatment Outcome, Echocardiography, Multidetector Computed Tomography, Medicine, Humans, Cardiology and Cardiovascular Medicine, business, Aneurysm, False
Published: 2020

12. Aortic valve area calculation using 3D transesophageal echocardiography: Implications for aortic stenosis severity grading

Author: Marco Ancona, Antonio Esposito, Stefano Stella, Anna Palmisano, Giacomo Ingallina, Matteo Montorfano, Antonio Colombo, Giulio Falasconi, Francesco Moroni, Luigi Pannone, Azeem Latib, Francesco Melillo, Eustachio Agricola, Vittorio Romano Rt, Alessandro Beneduce, Francesco Ancona, Cristina Capogrosso, Beneduce, A., Capogrosso, C., Moroni, F., Ancona, F., Falasconi, G., Pannone, L., Stella, S., Ingallina, G., Melillo, F., Ancona, M. B., Romano RT, V., Palmisano, A., Latib, A., Colombo, A., Montorfano, M., Esposito, A., and Agricola, E.
Subjects: Male, Echocardiography, Three-Dimensional, multidetector computed tomography, Severity grading, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Multidetector computed tomography, medicine, Cutoff, Ventricular outflow tract, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Grading (tumors), Reproducibility, business.industry, aortic stenosis, Reproducibility of Results, Stroke volume, Aortic Valve Stenosis, medicine.disease, Stenosis, Aortic Valve, 3D transesophageal echocardiography, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, Nuclear medicine, business, human activities, Echocardiography, Transesophageal
Abstract: Aims: Aortic stenosis (AS) grading by 2D-transthoracic echocardiography (2D-TTE) aortic valve area (AVA) calculation is limited by left ventricular outflow tract (LVOT) area underestimation. The combination of Doppler parameters with 3D LVOT area obtained by multidetector computed tomography (MDCT) can improve AS grading, reconciling discordant 2D-TTE findings. This study aimed to systematically evaluate the role of 3D-transesophageal echocardiography (3D-TEE) in AS grading using MDCT as reference standard. Methods and results: 288 patients (81±6.3years, 52.4% female) with symptomatic AS underwent 2D-TTE, 3D-TEE, and MDCT for transcatheter aortic valve implantation. Doppler parameters were combined with 3D LVOT areas measured by manual and semi-automated software 3D-TEE and by MDCT to calculate AVA, reassessing AS severity. Both 3D-TEE modalities demonstrated good correlation with MDCT, with excellent intra-observer and inter-observer variability. Compared to MDCT, 3D-TEE measurements significantly underestimated AVA (PANOVA&nbsp
Published: 2020

13. Surgical feasibility of ascending aorta manipulation after transcatheter aortic valve implantation: a computed tomography theoretical analysis

Author: Kusha Rahgozar, Vittorio Romano, Michele De Bonis, Ottavio Alfieri, Igor Belluschi, Matteo Montorfano, Pál Maurovich-Horvat, Alessandro Castiglioni, Júlia Karády, Ole De Backer, Nicola Buzzatti, Lars Søndergaard, Antonio Colombo, and Azeem Latib
Subjects: medicine.medical_specialty, Transcatheter aortic, medicine.medical_treatment, Computed tomography, Transcatheter Aortic Valve Replacement, Clinical Research, medicine.artery, Ascending aorta, medicine, Humans, Heart valve, Aorta, Retrospective Studies, Heart Valve Prosthesis Implantation, medicine.diagnostic_test, business.industry, Stent, Aortic Valve Stenosis, Aortic wall, Cardiac surgery, medicine.anatomical_structure, Treatment Outcome, Aortic Valve, Heart Valve Prosthesis, Feasibility Studies, Radiology, Cardiology and Cardiovascular Medicine, business, Tomography, X-Ray Computed, Artery
Abstract: Aims TAVI expansion will imply an increase in the frequency of emergent or late cardiac surgery after THV implantation. This study was designed to investigate the anatomical feasibility of surgical cross-clamp and aortotomy after TAVI through a post-TAVI CT-scan assessment. Methods and results We retrospectively analyzed 117 CTs acquired after TAVI procedures with high stent prostheses in three high-volume centers between October 2008 and May 2017. The mean distance observed between the innominate artery and the top of the transcatheter heart valve was 45 ± 11 mm, being l 30 mm in 8/117 (6.8%) patients and l 20 mm in none. The mean distance between the sino-tubular junction and the first free site for aortotomy being 22 ± 7 mm (g 20 mm in 78/117 [66.7%] cases). A total of 56/117 (47.9%) patients showed a complete continuous contact between the anterior aortic wall and the anterior part of the valve stent. Conclusions Aortic cross-clamp appears to not be an issue when cardiac surgery is needed after a TAVI, but a careful and possibly higher aortotomy may be required. CT should be performed prior to planned cardiac surgery after TAVI to determine a safe positioning for aortic cross-clamp and aortotomy.
Published: 2020

14. Self-expandable valve-in-valve treatment for failing sutureless aortic bioprosthesis

Author: Matteo Montorfano, Igor Belluschi, Vittorio Romano, Michele De Bonis, Andrea Blasio, Ottavio Alfieri, Alessandro Castiglioni, Nicola Buzzatti, Belluschi, I., Buzzatti, N., Blasio, A., Romano, V., De Bonis, M., Castiglioni, A., Montorfano, M., and Alfieri, O.
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, valve-in-valve, Self expandable, business.industry, medicine.medical_treatment, Regurgitation (circulation), 030204 cardiovascular system & hematology, SAVR, medicine.disease, Prosthesis, Valve in valve, Surgery, TAVI, 03 medical and health sciences, suturele, 0302 clinical medicine, 030228 respiratory system, Aortic valve replacement, Heart team, medicine, Cardiology and Cardiovascular Medicine, Symptomatic aortic stenosis, business
Abstract: Aortic valve replacement still represents the gold standard treatment for severe symptomatic aortic stenosis. Sutureless bioprostheses have been so far developed to enhance the minimally invasive approach, resulting in a reduction of cross-clamp time. Even if the first implantation was carried out more than 10 years ago, some cases of valve degeneration treated with balloon-expandable valve-in-valve procedures have been previously described in the literature. Here, we present a case of early sutureless valve degeneration resulting in severe aortic regurgitation. After careful evaluation of the patient's comorbidities, a successful valve-in-valve was finally performed using a self-expandable transcatheter prosthesis. A wide discussion of the Heart Team decision-making process and of the technical aspects has been addressed.
Published: 2020

15. A computed tomography study of coronary access and coronary obstruction after redo transcatheter aortic valve implantation

Author: Antonio Colombo, Liesbeth Rosseel, Vittorio Romano, Júlia Karády, Azeem Latib, Michele De Bonis, Ole De Backer, Bernard Prendergast, Nicola Buzzatti, Pál Maurovich-Horvat, Matteo Montorfano, Béla Merkely, Lars Søndergaard, Buzzatti, Nicola, Montorfano, Matteo, Romano, Vittorio, De Backer, Ole, Søndergaard, Lar, Rosseel, Liesbeth, Maurovich-Horvat, Pal, Karady, Julia, Merkely, Béla, Prendergast, Bernard D, De Bonis, Michele, Colombo, Antonio, and Latib, Azeem
Subjects: medicine.medical_specialty, Transcatheter aortic, Computed tomography, 030204 cardiovascular system & hematology, Prosthesis Design, Coronary artery disease, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Multidetector computed tomography, Multidetector Computed Tomography, Medicine, Humans, 030212 general & internal medicine, medicine.diagnostic_test, business.industry, Sinotubular Junction, Aortic Valve Stenosis, medicine.disease, Coronary ostium, Increased risk, Coronary Occlusion, Coronary occlusion, Aortic Valve, Heart Valve Prosthesis, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract: AIMS The aim of this study was to investigate the risk of impaired coronary access and coronary obstruction after redo TAVI. METHODS AND RESULTS Post-procedure multidetector computed tomography (MDCT) scans of 221 TAVI recipients were analysed. Increased risk of impaired coronary access was defined as a coronary ostium below the TAVI commissures with a valve-to-aorta distance
Published: 2020

16. Anatomic and procedural associations of transcatheter heart valve displacement following Evolut R implantation

Author: Marco Ancona, Azeem Latib, Ozan M. Demir, Vittorio Romano, Fabrizio Monaco, Satoru Mitomo, Antonio Colombo, Damiano Regazzoli, Nicola Buzzatti, Daisuke Hachinohe, Paolo Del Sole, Francesco Giannini, Pier Pasquale Leone, Alessandra Laricchia, Antonio Mangieri, Eustachio Agricola, Matteo Montorfano, Hachinohe, Daisuke, Latib, Azeem, Laricchia, Alessandra, Demir, Ozan M., Agricola, Eustachio, Romano, Vittorio, Del Sole, Paolo Alberto, Leone, Pier Pasquale, Ancona, Marco B., Mangieri, Antonio, Regazzoli, Damiano, Giannini, Francesco, Mitomo, Satoru, Monaco, Fabrizio, Buzzatti, Nicola, Montorfano, Matteo, and Colombo, Antonio
Subjects: Male, displacement, Radiology, Nuclear Medicine and Imaging, medicine.medical_specialty, Time Factors, Transcatheter aortic, TAVR, 030204 cardiovascular system & hematology, Prosthesis Design, Severity of Illness Index, Transcatheter Aortic Valve Replacement, TAVI, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Risk Factors, Upward displacement, Internal medicine, medicine.artery, Linear regression, Ascending aorta, medicine, Humans, Radiology, Nuclear Medicine and imaging, Displacement (orthopedic surgery), 030212 general & internal medicine, Heart valve, transcatheter aortic valve implantation, Aged, Retrospective Studies, Aged, 80 and over, Bioprosthesis, business.industry, Aortic Valve Stenosis, General Medicine, aortic stenosi, Confidence interval, Treatment Outcome, medicine.anatomical_structure, Aortic Valve, Heart Valve Prosthesis, Cardiology, Female, self-expanding, Multiple linear regression analysis, Cardiology and Cardiovascular Medicine, business
Abstract: Objectives This study aimed to predict the displacement of self-expanding transcatheter heart valves (THV) during final deployment. Background Accurate device positioning during transcatheter aortic valve implantation (TAVI) is crucial for optimal results. Methods At our institution, 103 patients who underwent transfemoral TAVI with Evolut R were retrospectively identified. Multiple linear regression models were created, and a predictor equation was built to quantify the factors that may affect THV behavior. Results Multiple linear regression analysis for THV displacement on the left coronary cusp (LCC) identified the angle between the THV and the ascending aorta (ATA), predilation, and less operator experience as independent predictors of upward displacement, whereas estimated glomerular filtration rate (eGFR) was inversely related with THV behavior (95% confidence interval: 0.219 to 0.340, 0.447 to 2.092, 0.165 to 1.757, and -0.053 to -0.011, respectively). Predictors of THV displacement on the noncoronary cusp side could not be identified using this model. Conclusions The ATA at the point of recapture, predilation, and less operator experience were independent predictors of upward displacement of THV on the LCC side. eGFR was an independent predictor of THV downward displacement on the LCC side. Of them, the ATA was the strongest predictor. Physicians may need to adjust this angle adequately before deployment to achieve the appropriate position.
Published: 2018

17. Tricento Transcatheter Heart Valve for Severe Tricuspid Regurgitation

Author: Alaide Chieffo, Marco Ancona, Francesco Moroni, Vittorio Romano, Francesco Ancona, F Sgura, Eustachio Agricola, Barbara Bellini, Mauro Carlino, Alessandro Beneduce, Matteo Montorfano, Luca A. Ferri, and Saud Khawaja
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Peripheral edema, Computed tomography, Regurgitation (circulation), 030204 cardiovascular system & hematology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Aortic valve replacement, Internal medicine, Heart failure, medicine, Cardiology, Chronic atrial fibrillation, 030212 general & internal medicine, Heart valve, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract: An 82-year-old woman with chronic atrial fibrillation, previous aortic valve replacement with a self-expandable transcatheter heart valve (THV), and multiple hospitalizations for congestive heart failure presented to our institution with diuretic-resistant peripheral edema and New York Heart
Published: 2019

18. Transcatheter Pulmonary Valve Replacement With 32-mm Balloon-Expandable Prosthesis

Author: Nicola Buzzatti, Antonio Esposito, RT Vittorio Romano, Marco Ancona, and Matteo Montorfano
Subjects: medicine.medical_specialty, Balloon expandable stent, business.industry, Pulmonary Valve Replacement, medicine.medical_treatment, Medicine, Cardiology and Cardiovascular Medicine, business, Prosthesis, Surgery
Published: 2021

19. A comparison of the fully repositionable and retrievable <scp>B</scp> oston <scp>L</scp> otus and direct flow medical valves for the treatment of severe aortic stenosis: A single center experience

Author: Neil Ruparelia, Ottavio Alfieri, Alaide Chieffo, Richard J. Jabbour, Vittorio Romano, Matteo Montorfano, Luca A. Ferri, Francesco Giannini, Marco Ancona, Akihito Tanaka, Matteo Longoni, Azeem Latib, Damiano Regazzoli, Antonio Colombo, Lorenzo Azzalini, Eustachio Agricola, Nicola Buzzatti, Antonio Mangieri, Giannini, Francesco, Latib, Azeem, Montorfano, Matteo, Ruparelia, Neil, Romano, Vittorio, Longoni, Matteo, Ferri, Luca, Jabbour, Richard, Mangieri, Antonio, Regazzoli, Damiano, Ancona, Marco, Buzzatti, Nicola, Azzalini, Lorenzo, Tanaka, Akihito, Agricola, Eustachio, Chieffo, Alaide, Alfieri, Ottavio, and Colombo, Antonio
Subjects: Male, Radiology, Nuclear Medicine and Imaging, medicine.medical_specialty, Time Factors, Transcatheter aortic, medicine.medical_treatment, Severe aortic stenosi, 030204 cardiovascular system & hematology, Prosthesis Design, Single Center, Severity of Illness Index, Direct flow, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Embolization, Paravalvular leak, Clinical efficacy, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Lotus valve system, fungi, Hemodynamics, Aortic Valve Stenosis, Recovery of Function, General Medicine, medicine.disease, Surgery, Stenosis, Treatment Outcome, Trans-femoral aortic valve implantation, Italy, Echocardiography, Aortic Valve, Heart Valve Prosthesis, Cardiology, Female, Technological advance, Cardiology and Cardiovascular Medicine, business, Direct flow medical valve system
Abstract: Background Second generation transcatheter aortic valve implantation (TAVI) devices have been designed to reduce the rate of paravalvular leak (PVL) and other complications. An important technological advancement has been the ability to fully reposition devices to facilitate optimal implantation depth and position to reduce the likelihood of PVL. Objectives To compare procedural and 30-day outcomes according to the Valve Academic Research Consortium (VARC)-2 criteria following TAVI with the fully repositionable and retrievable Lotus and DFM devices. Methods and Results 175 patients with severe aortic stenosis underwent transfemoral TAVI with the Lotus (n = 60) and DFM (n = 115) valve. Baseline clinical characteristics did not differ between the two groups. All devices were successfully implanted, with one case of valve embolization in the Lotus group. Device success (95 vs. 98.2%, P = 0.89), VARC-defined combined safety (90 vs. 93%, P = 0.48), and clinical efficacy (86.7 vs. 90.4%, P = 0.65) rates at 30-days were similar between Lotus and DFM groups. There was no severe PVL; one patient in both Lotus and DFM group developed moderate PVL after the procedure. The Lotus valve was associated with a higher rate of new pacemaker implantation (37.3 vs. 11.2%, P
Published: 2017

20. TAVR in a patient with an anomalous left main: Self-expanding prosthesis might be the preferred choice

Author: Barbara Bellini, Matteo Montorfano, Vittorio Romano, Fabio Sgura, Marco Ancona, and Georgios Tzanis
Subjects: lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, business.industry, medicine.medical_treatment, Aortic Valve Stenosis, Prosthesis Design, Prosthesis, Surgery, Transcatheter Aortic Valve Replacement, Treatment Outcome, lcsh:RC666-701, Risk Factors, Aortic Valve, Heart Valve Prosthesis, medicine, Humans, Cardiology and Cardiovascular Medicine, business
Published: 2020

21. Valve-in-Valve With Allegra Implantation in Failed Direct Flow Transcatheter Heart Valve

Author: Francesco Ancona, Saud Khawaja, Nicola Buzzatti, Eustachio Agricola, Matteo Montorfano, Alessandro Beneduce, Luca A. Ferri, Marco Ancona, Anna Palmisano, Barbara Bellini, Francesco Moroni, Antonio Esposito, Emanuele Visco, RT Vittorio Romano, Ancona, M. B., Visco, E., Khawaja, S., Romano, V., Moroni, F., Ferri, L., Bellini, B., Beneduce, A., Ancona, F., Agricola, E., Buzzatti, N., Palmisano, A., Esposito, A., and Montorfano, M.
Subjects: valve-in-valve, medicine.medical_specialty, Transcatheter aortic, business.industry, medicine.medical_treatment, Hemodynamics, 030204 cardiovascular system & hematology, medicine.disease, Direct flow, Valve in valve, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Valve replacement, direct flow, Internal medicine, Heart failure, Aortic valve surgery, medicine, Cardiology, Allegra, 030212 general & internal medicine, Heart valve, Cardiology and Cardiovascular Medicine, business
Abstract: An 87-year-old man with a history of transcatheter aortic valve replacement with a 6-year-old 27-mm Direct Flow bioprosthesis (Direct Flow Medical, Santa Rosa, California), presented with heart failure. Echocardiography showed normal transcatheter heart valve (THV) leaflets with no obstruction (mean
Published: 2020

22. Multimodality Imaging for Transcatheter Paravalvular Leak Closure in Radiolucent Mitral Bioprosthesis

Author: Stefano Stella, Eustachio Agricola, Alessandro Beneduce, Cristina Capogrosso, Marco Ancona, Francesco Ancona, Vittorio Romano, Matteo Montorfano, Beneduce, A., Ancona, F., Ancona, M. B., Romano, V., Stella, S., Capogrosso, C., Montorfano, M., and Agricola, E.
Subjects: Male, mitral valve, medicine.medical_specialty, Radiodensity, Echocardiography, Three-Dimensional, Heart Valve Diseases, Closure (topology), heart failure, multimodal imaging, Multimodal Imaging, Mitral valve, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Paravalvular leak, Aged, Multimodal imaging, business.industry, fiducial marker, Echocardiography, Doppler, Color, Prosthesis Failure, Treatment Outcome, medicine.anatomical_structure, bioprosthesi, Mitral Valve, Radiology, Cardiology and Cardiovascular Medicine, Fiducial marker, business, Echocardiography, Transesophageal
Published: 2019

23. Chimney technique for coronary obstruction after aortic valve in valve: pros and cons

Author: Nicola Buzzatti, Antonio Colombo, Azeem Latib, Matteo Montorfano, and Vittorio Romano
Subjects: Aortic valve, medicine.medical_specialty, 030204 cardiovascular system & hematology, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, Blood Vessel Prosthesis Implantation, Ventricular Dysfunction, Left, 0302 clinical medicine, X ray computed, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Chimney, 030212 general & internal medicine, business.industry, cons, General Medicine, medicine.anatomical_structure, Coronary Occlusion, Coronary occlusion, Heart Valve Prosthesis, Stents, Radiology, Cardiology and Cardiovascular Medicine, business, Tomography, X-Ray Computed
Published: 2018

24. Ventricular septal defect and left ventricular outflow tract obstruction after transcatheter aortic valve implantation

Author: Matteo Montorfano, Damiano Regazzoli, Ottavio Alfieri, Michele Cacucci, Nicola Buzzatti, Vittorio Romano, Francesco Giannini, Marco Ancona, Francesco Ancona, Alessandro Castiglioni, Azeem Latib, Stefano Stella, Eustachio Agricola, Antonio Colombo, Manuela Giglio, Antonio Mangieri, Ancona, Marco, Castiglioni, Alessandro, Giannini, Francesco, Mangieri, Antonio, Regazzoli, Damiano, Romano, Vittorio, Giglio, Manuela, Ancona, Francesco, Stella, Stefano, Agricola, Eustachio, Cacucci, Michele, Buzzatti, Nicola, Alfieri, Ottavio, Montorfano, Matteo, Colombo, Antonio, and Latib, Azeem
Subjects: Heart Septal Defects, Ventricular, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Transcatheter aortic, Ventricular outflow tract obstruction, Left ventricular hypertrophy, Ventricular Outflow Obstruction, Transcatheter Aortic Valve Replacement, Postoperative Complications, Internal medicine, left ventricular outflow tract obstruction, medicine, Humans, cardiovascular diseases, intracardiac shunt after transcatheter aortic valve implantation, transcatheter aortic valve implantation, Aged, 80 and over, Heart septal defect, business.industry, Aortic Valve Stenosis, General Medicine, medicine.disease, Aortic Valve Stenosi, ventricular septal defect, Heart Valve Prosthesi, Echocardiography, Heart Valve Prosthesis, Heart failure, cardiovascular system, Cardiology, Female, Postoperative Complication, medicine.symptom, Complication, business, Cardiology and Cardiovascular Medicine, Human
Abstract: Ventricular septal defect (VSD) has been reported as a rare complication after transcatheter aortic valve implantation (TAVI), presenting with signs of heart failure. Furthermore, left ventricular outflow tract obstruction (LVOTO) may worsen after TAVI, especially in cases of severe left ventricular hypertrophy and small cavity. However, the simultaneous appearance of VSD and LVOT after TAVI has not been reported before. We report a case of combined VSD and LVOTO after TAVI.
Published: 2018

25. Transcatheter Treatment of Pure Aortic Regurgitation in a Horizontal Aorta Complicated by Valve Embolization and Aortic Dissection

Author: Matteo Pagnesi, Francesco Ponticelli, Francesco Giannini, Antonio Colombo, Antonio Mangieri, Giuseppe Lanzillo, Alessandra Laricchia, Marco Ancona, Vittorio Romano, and Azeem Latib
Subjects: Aortic dissection, medicine.medical_specialty, Aorta, business.industry, medicine.medical_treatment, General Medicine, Regurgitation (circulation), 030204 cardiovascular system & hematology, medicine.disease, Surgery, 03 medical and health sciences, 0302 clinical medicine, Bicuspid aortic valve, Valve replacement, medicine.artery, Ascending aorta, cardiovascular system, medicine, 030212 general & internal medicine, Embolization, Cardiology and Cardiovascular Medicine, Complication, business
Abstract: A 83-year-old female with severe aortic regurgitation (AR) and an horizontal ascending aorta was scheduled for a transcatheter aortic valve replacement . After the complete deployment, a Portico 29 mm valve embolized in the ascending aorta due to the unfavorable anatomy of the anchoring zone. A second Portico 29 mm was successfully implanted using the embolized valve for superior anchoring. The patient died 7 days after the procedure due to a retrograde aortic dissection . This case shows a rare but possible complication that occurs especially in unfavorable and complex aortic anatomies.
Published: 2019

26. Operational definition of Active and Healthy Ageing (AHA)

Author: Henriette A. Smit, Neil Wilson, Jean-Marie Robine, J. Y. Pelissier, M. Van Beurden, A. Bedbrook, T. Standberg, Vittorio Romano, Bertrand Fougère, J. Garcia-Aymerich, C. Jeandel, Anne Hendry, B. Samolinski, Mike Bewick, Holger Schulz, P. Bertone, Yoav Ben-Shlomo, J. Coletta, D. Poethig, J. P. Michel, Valentina A. Andreeva, M. O'Neill, M. Nogues, K. Andersen Ranberg, Elena Villalba-Mora, Daniel Laune, Itziar Vergara, Maddalena Illario, F. Roubille, G. J. Buijs, J. Venne, Sylvie Arnavielhe, L. Rodriguez Manas, Carol Brayne, David Somekh, T. Camuzat, Jacques Bringer, A. Nizinkska, Marcel Goldberg, Carel Thijs, Alessandro Blasimme, Raphaëlle Varraso, Dieter Maier, Marie Zins, D. Heve, François Puisieux, Theodore D. Cosco, D. Harman, João O. Malva, Thomas Keil, Rachel Cooper, J. Mercier, M. Criton, Alfredo Cesario, Philippe-Jean Bousquet, Jean Bousquet, Davide Caimmi, John Farrell, Emmanuelle Kesse-Guyot, Dirkje S. Postma, Karen Ritchie, Joël Ankri, P. Viriot-Durandal, Pascal Demoly, G. Moda, V. Traver-Salcedo, Susanne Krauss-Etschmann, Daniela Porta, D. Kula, Jordi Alonso, Federico Alonso, Ana Todo-Bom, Frédéric Cuisinier, R. Pengelly, Guido Iaccarino, G. Mercier, C. Robalo-Cordeiro, Eveline Wouters, P. Senesse, P. Matignon, J. Touchon, Sergio Bonini, B. Combe, J. Suanzes, Marek L. Kowalski, A. Zaidi, Isabelle Momas, R. Bourret, Hasan Arshad, A. Avignon, Sylvain Lehmann, Ana Maria Carriazo, Diana Kuh, Claudine Berr, Mai Stafford, A. Scott, Marcus Richards, S. Fernandez-Nocelo, Rebecca Hardy, Z. Gutter, M. E. Joel, Erik Melén, C. Tischer, Sandra N. Slagter, Nick A. Guldemond, Bruno Vellas, H. Blain, P. Auge, O. Krys, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, Institut d'Electronique du Solide et des Systèmes (InESS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Departamento de Biología Molecular y Celular del Cáncer (CSIC-UAM), Instituto de Investigaciones Biomédicas A. Sols, Hôpital Lapeyronie [Montpellier] (CHU), Institut de Génétique Moléculaire de Montpellier (IGMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Mécanismes moléculaires dans les démences neurodégénératives (MMDN), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), École des hautes études en sciences sociales (EHESS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Gérontopôle, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse], Université Paris-Est Marne-la-Vallée (UPEM), Université de Montpellier (UM), Euromov (EuroMov), Eindhoven University of Technology [Eindhoven] (TU/e), Laboratoire de Bioingénierie et NanoSciences (LBN), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, IMIM-Hospital del Mar, Generalitat de Catalunya, Groupe Matrice Extracellulaire et Biomineralisation, Université Paris Descartes - Paris 5 (UPD5), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], Service de Pneumologie, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPC), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon ( MACVIA-LR ), Université Montpellier 1 ( UM1 ) -World Health Organization ( WHO/OMS ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -European Innovation Partnership on Active and Healthy Ageing Reference Site, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] ( PhyMedExp ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de pharmacologie et innovation dans le diabète ( CPID ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Centre National de la Recherche Scientifique ( CNRS ), Medical University of Warsaw-Faculté de Pharmacie de Paris, CNR, Rome, Italy and Department of Medicine-Second University of Naples, Institut d'Electronique du Solide et des Systèmes ( InESS ), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS ), Departamento de Biología Molecular y Celular del Cáncer ( CSIC-UAM ), Hôpital Lapeyronie [Montpellier] ( CHU ), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle ( CRESS - U1153 ), Université Paris 13 ( UP13 ) -Institut National de la Recherche Agronomique ( INRA ) -Conservatoire National des Arts et Métiers [CNAM] ( CNAM ) -Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ), Gerontopole of Toulouse, CHU- Université de Toulouse, Université Paris-Est Marne-la-Vallée ( UPEM ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Eindhoven University of Technology [Eindhoven] ( TU/e ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Arnaud de Villeneuve, Université Paris Descartes - Paris 5 ( UPD5 ), Institut de Recherche en Infectiologie de Montpellier ( IRIM ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ), Institut de génétique humaine ( IGH ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire AIM, Université Paris Diderot - Paris 7 ( UPD7 ) -Centre d'Etudes de Saclay, Telecom Bretagne, Brest, Laboratoire de magnétisme et d'optique de Versailles ( LMOV ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Centre National de la Recherche Scientifique ( CNRS ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Departement de Cardiologie, Space Science Division, Neuropsychiatrie : recherche épidémiologique et clinique, Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Antoine Béclère, UMS11 Cohortes en population, Institut National de la Santé et de la Recherche Médicale ( INSERM ), Bousquet, J, Kuh, D, Bewick, M, Standberg, T, Farrell, J, Pengelly, R, Joel, M. E, Rodriguez Mañas, L, Mercier, J, Bringer, J, Camuzat, T, Bourret, R, Bedbrook, A, Kowalski, M. L, Samolinski, B, Bonini, S, Brayne, C, Michel, J. P, Venne, J, Viriot Durandal, P, Alonso, J, Avignon, A, Ben Shlomo, Y, Bousquet, P. J, Combe, B, Cooper, R, Hardy, R, Iaccarino, G, Keil, T, Kesse Guyot, E, Momas, I, Ritchie, K, Robine, J. M, Thijs, C, Tischer, C, Vellas, B, Zaidi, A, Alonso, F, Andersen Ranberg, K, Andreeva, V, Ankri, J, Arnavielhe, S, Arshad, H, Augé, P, Berr, C, Bertone, P, Blain, H, Blasimme, A, Buijs, G. J, Caimmi, D, Carriazo, A, Cesario, A, Coletta, J, Cosco, T, Criton, M, Cuisinier, F, Demoly, P, Fernandez Nocelo, S, Fougère, B, Garcia Aymerich, J, Goldberg, M, Guldemond, N, Gutter, Z, Harman, D, Hendry, A, Heve, D, Illario, Maddalena, Jeandel, C, Krauss Etschmann, S, Krys, O, Kula, D, Laune, D, Lehmann, S, Maier, D, Malva, J, Matignon, P, Melen, E, Mercier, G, Moda, G, Nizinkska, A, Nogues, M, O'Neill, M, Pelissier, J. Y, Poethig, D, Porta, D, Postma, D, Puisieux, F, Richards, M, Robalo Cordeiro, C, Romano, V, Roubille, F, Schulz, H, Scott, A, Senesse, P, Slagter, S, Smit, H. A, Somekh, D, Stafford, M, Suanzes, J, Todo Bom, A, Touchon, J, Traver Salcedo, V, Van Beurden, M, Varraso, R, Vergara, I, Villalba Mora, E, Wilson, N, Wouters, E, Zins, M., CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), École Pratique des Hautes Études (EPHE), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Bousquet, Jean, Kuh, D., Bewick, M., Standberg, T., Farrell, J., Pengelly, R., Joel, M. E., Rodriguez Mañas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M. L., Samolinski, B., Bonini, Sergio, Brayne, C., Michel, J. P., Venne, J., Viriot Durandal, P., Alonso, J., Avignon, A., Ben Shlomo, Y., Bousquet, P. J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse Guyot, E., Momas, I., Ritchie, K., Robine, J. M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Andersen Ranberg, K., Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, H., Augé, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G. J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez Nocelo, S., Fougère, B., Garcia Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeande, C., Krauss Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., O’Neill, M., Pelissier, J. Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H. A., Somekh, D., Stafford, M., Suanzes, J., Todo Bom, A., Touchon, J., Traver Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba Mora, E., Wilson, N., Wouters, E., Groningen Research Institute for Asthma and COPD (GRIAC), Epidemiologie, RS: CAPHRI School for Public Health and Primary Care, RS: CAPHRI - R5 - Optimising Patient Care, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-École pratique des hautes études (EPHE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Antoine Béclère, UMS011 Cohortes épidémiologiques en population (CONSTANCES), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Gerontology, Aging, media_common.quotation_subject, [SDV]Life Sciences [q-bio], EUROPEAN INNOVATION PARTNERSHIP, Population, Medicine (miscellaneous), Social Environment, MACVIA-LR, Quality of life (healthcare), European Innovation Partnership on Active and Healthy Ageing, Active and Healthy Ageing, PREVENTING CHRONIC DISEASES, definition, Nutrition and Dietetics, Geriatrics and Gerontology, LIFE YEARS, Nutrition and Dietetic, Journal Article, Medicine, Humans, DISEASES CHRONIC DISEASES, Function (engineering), education, Exercise, ComputingMilieux_MISCELLANEOUS, POPULATION, media_common, education.field_of_study, [ SDV ] Life Sciences [q-bio], business.industry, Operational definition, EIP, Social environment, Conceptual framework, Health, General partnership, Chronic Disease, Quality of Life, France, Independent Living, business, Independent living, Human, macvia lr
Abstract: Health is a multi-dimensional concept, capturing how people feel and function. The broad concept of Active and Healthy Ageing was proposed by the World Health Organisation (WHO) as the process of optimizing opportunities for health to enhance quality of life as people age. It applies to both individuals and population groups. A universal Active and Healthy Ageing definition is not available and it may differ depending on the purpose of the definition and/or the questions raised. While the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) has had a major impact, a definition of Active and Healthy Ageing is urgently needed. A meeting was organised in Montpellier, France, October 20-21, 2014 as the annual conference of the EIP on AHA Reference Site MACVIA-LR (Contre les Maladies Chroniques pour un Vieillissement Actif en Languedoc Roussillon) to propose an operational definition of Active and Healthy Ageing including tools that may be used for this. The current paper describes the rationale and the process by which the aims of the meeting will be reached. Health is a multi-dimensional concept, capturing how people feel and function. The broad concept of Active and Healthy Ageing was proposed by the World Health Organisation (WHO) as the process of optimizing opportunities for health to enhance quality of life as people age. It applies to both individuals and population groups. A universal Active and Healthy Ageing definition is not available and it may differ depending on the purpose of the definition and/or the questions raised. While the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) has had a major impact, a definition of Active and Healthy Ageing is urgently needed. A meeting was organised in Montpellier, France, October 20-21, 2014 as the annual conference of the EIP on AHA Reference Site MACVIA-LR (Contre les Maladies Chroniques pour un Vieillissement Actif en Languedoc Roussillon) to propose an operational definition of Active and Healthy Ageing including tools that may be used for this. The current paper describes the rationale and the process by which the aims of the meeting will be reached.
Published: 2015

27. Valve embolization with a second-generation fully-retrievable and repositionable transcatheter aortic valve

Author: Azeem Latib, Antonio Colombo, Neil Ruparelia, Susanna Benincasa, Francesco Giannini, Matteo Montorfano, Vittorio Romano, and Richard J. Jabbour
Subjects: 0301 basic medicine, Aortic valve, medicine.medical_specialty, Transcatheter aortic, medicine.medical_treatment, 030204 cardiovascular system & hematology, Prosthesis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Embolization, Cardiac catheterization, business.industry, fungi, food and beverages, medicine.disease, First generation, Surgery, medicine.anatomical_structure, Aortic valve stenosis, Cardiology, 030101 anatomy & morphology, Permanent pacemaker, Cardiology and Cardiovascular Medicine, business
Abstract: Valve embolization during transcatheter aortic valve implantation is a rare but potentially fatal complication of first generation transcatheter valves. As a result, second generation valves were designed to be fully retrievable and minimize this complication. We report a first case of embolization with a second-generation fully-retrievable and repositionable Lotus valve. In this case, the presence of severe left ventricular hypertrophy and a sigmoid septum may have contributed to prosthesis embolization with the initial 23mm Lotus valve. With the high implantation we performed with the 23mm Lotus valve, the septal bulging may have interfered with the high implanted Lotus valve, resulting in the "watermelon seeding" phenomenon, whereby the sigmoidal septum squeezes the valve out of place distally, in spite of the initial appearance of stability. With the 25mm Lotus valve, the lower implantation height, and the prosthesis oversizing, with greater radial strength, ensured greater stability of the valve. This case highlights the importance of meticulous pre-TAVI assessment of subvalvular geometry, irrespective of the use of newer devices that are repositionable and retrievable. The identification of severe hypertrophy in the subvalvular landing zone should be incorporated into the decision-making process with the possible selection of a self-expanding prosthesis and/or a lower implantation height of an over-sized prosthesis with the Lotus valve to ensure greater valve stability whilst accepting the higher likelihood of the requirement for permanent pacemaker implantation.
Published: 2016

28. Impact of Mitral Annular Calcium on Outcomes after Transcatheter Aortic Valve Implantation

Author: Marco Ancona, Matteo Longoni, Luca Testa, Eustachio Agricola, Antonio Colombo, Damiano Regazzoli, Alaide Chieffo, Akihito Tanaka, Richard J. Jabbour, Ottavio Alfieri, Azeem Latib, Francesco Giannini, Manuela Giglio, Matteo Montorfano, Antonio Mangieri, Vittorio Romano, Francesca Besana, Michele Cacucci, Ancona, Marco B., Giannini, Francesco, Mangieri, Antonio, Regazzoli, Damiano, Jabbour, Richard J., Tanaka, Akihito, Testa, Luca, Romano, Vittorio, Longoni, Matteo, Giglio, Manuela, Besana, Francesca, Cacucci, Michele, Agricola, Eustachio, Chieffo, Alaide, Alfieri, Ottavio, Montorfano, Matteo, Colombo, Antonio, and Latib, Azeem
Subjects: Male, medicine.medical_specialty, Population, Aortic Valve Insufficiency, Disease, 030204 cardiovascular system & hematology, Follow-Up Studie, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Retrospective Studie, Risk Factors, Internal medicine, Diabetes mellitus, medicine, Prevalence, Humans, 030212 general & internal medicine, education, Retrospective Studies, Aged, 80 and over, education.field_of_study, business.industry, Mortality rate, Risk Factor, Calcinosis, Retrospective cohort study, Atrial fibrillation, medicine.disease, Surgery, Survival Rate, Italy, Cardiology, Calcinosi, Mitral Valve, Calcium, Female, Postoperative Complication, business, Cardiology and Cardiovascular Medicine, Tomography, X-Ray Computed, Kidney disease, Calcification, Human, Follow-Up Studies
Abstract: A high prevalence of mitral annular calcium (MAC) is expected in patients undergoing transcatheter aortic valve implantation (TAVI); however, data regarding the prevalence of MAC and impact on risk of cardiovascular events are lacking. To determine the prevalence of MAC and its association with clinical outcomes in patients undergoing TAVI, we retrospectively analyzed 424 patients who underwent transfemoral TAVI from 2007 to 2015 and whose preoperative computed tomography images were available for assessment of MAC. Severe circumferential MAC (SC-MAC) was defined as calcification involving at least the whole posterior annulus alone or with the attachment of the anterior leaflet. Clinical outcomes were examined according to Valve Academic Research Consortium-2 criteria up to 2 years. SC-MAC was found in 17.7% of patients. Patients with SC-MAC were more likely to be female, with a higher prevalence of atrial fibrillation and peripheral artery disease. There were no differences between the groups regarding age, functional class, prevalence of diabetes, kidney disease, and operative risk. Female gender and peripheral artery disease were independent predictors of SC-MAC. SC-MAC did not appear to be associated with periprocedural and 30-day outcomes. At 2 years' follow-up, patients with SC-MAC had significantly higher cardiovascular and all-cause mortality rates. SC-MAC was an independent predictor of cardiovascular mortality during follow-up. In conclusion, SC-MAC is a frequent finding in the TAVI population and appears to be an independent predictor of cardiovascular mortality at 2 years' follow-up.
Published: 2017

29. Patent foramen ovale closure through inferior vena cava filter in a patient with deep venous thrombosis and recurrent ischemic events

Author: Marco Ancona, Vittorio Romano, Moreno Tresoldi, Damiano Regazzoli, Giuseppe Lanzillo, Pier Pasquale Leone, Antonio Colombo, Matteo Montorfano, Eustachio Agricola, Akihito Tanaka, Azeem Latib, Antonio Mangieri, Regazzoli, Damiano, Ancona, Marco B., Mangieri, Antonio, Tanaka, Akihito, Romano, Vittorio, Leone, Pier P., Tresoldi, Moreno, Lanzillo, Giuseppe, Agricola, Eustachio, Latib, Azeem, Colombo, Antonio, and Montorfano, Matteo
Subjects: medicine.medical_specialty, Vena Cava Filters, Septal Occluder Device, Inferior vena cava filter, Foramen Ovale, Patent, 030204 cardiovascular system & hematology, Prosthesis Implantation, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Internal medicine, medicine, Secondary Prevention, Humans, 030212 general & internal medicine, Foramen ovale (heart), Aged, Secondary prevention, Vena cava filters, business.industry, Endovascular Procedures, General Medicine, medicine.disease, Surgery, Venous thrombosis, medicine.anatomical_structure, Patent foramen ovale, Cardiology, Female, business, Cardiology and Cardiovascular Medicine, Pulmonary Embolism
Published: 2017

30. Use of a parallel stiff wire to facilitate percutaneous Impella RP ventricular assist device positioning

Author: Neil Ruparelia, Richard J. Jabbour, Francesco Giannini, Azeem Latib, Antonio Colombo, Michele De Bonis, Valeria Magni, Federico Pappalardo, Matteo Montorfano, Vittorio Romano, Lorenzo Azzalini, Giannini, Francesco, Montorfano, Matteo, Jabbour, Richard J, Latib, Azeem, Ruparelia, Neil, Azzalini, Lorenzo, Magni, Valeria, Romano, Vittorio, DE BONIS, Michele, Pappalardo, Federico, and Colombo, Antonio
Subjects: Risk, medicine.medical_specialty, Percutaneous, medicine.medical_treatment, Shock, Cardiogenic, 030204 cardiovascular system & hematology, Impella, Right ventricular failure, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Aged, Heart Failure, business.industry, Tricuspid ring, General Medicine, Surgery, Treatment Outcome, Ventricular assist device, Cardiology, Female, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, business, Vascular Surgical Procedures
Abstract: Despite optimal medical management, some patients with severe right ventricular failure fail to respond and may benefit from additional support with the implantation of a RV assist device. Experience to date with Impella RP is limited. We report a case of percutaneous Impella RP implantation, using a parallel stiff wire to reduce anatomical tortuosity by acting as a buddy-wire to facilitate device implantation and reduce the risk of tricuspid ring damage in a patient recently treated with tricuspid ring annuloplasty.
Published: 2017

31. Transfemoral Lotus Valve Implantation for Treatment of Postendocarditis Stentless Prosthesis Degeneration With Pure Aortic Regurgitation

Author: Antonio Colombo, Francesco Giannini, Marco Ancona, Matteo Montorfano, Vittorio Romano, Azeem Latib, Damiano Regazzoli, Manuela Giglio, Antonio Mangieri, Ancona, Marco B., Giannini, Francesco, Mangieri, Antonio, Regazzoli, Damiano, Romano, Vittorio, Giglio, Manuela, Latib, Azeem, Colombo, Antonio, and Montorfano, Matteo
Subjects: Male, Reoperation, medicine.medical_specialty, Cardiac Catheterization, medicine.medical_treatment, Aortic Valve Insufficiency, Degeneration (medical), Regurgitation (circulation), 030204 cardiovascular system & hematology, Prosthesis Design, Prosthesis, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, 030212 general & internal medicine, Aged, 80 and over, Bioprosthesis, Heart Valve Prosthesis Implantation, business.industry, Endocarditis, Bacterial, Surgery, Prosthesis Failure, Femoral Artery, business, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, Echocardiography, Transesophageal
Published: 2017

32. TCT-97 Preserving coronary access after Valve-in-TAVI: a glimpse into the future

Author: Júlia Karády, Béla Merkely, Lars Søndergaard, Nicola Buzzatti, Matteo Montorfano, Azeem Latib, Bernard Prendergast, Antonio Colombo, Ole De Backer, Vittorio Romano, Pál Maurovich-Horvat, and Liesbeth Rosseel
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Stent, Computed tomography, equipment and supplies, cardiovascular system, medicine, lipids (amino acids, peptides, and proteins), cardiovascular diseases, Radiology, Cardiology and Cardiovascular Medicine, business, Medical science
Abstract: Valve-in-Valve after previous TAVI (ViT) pushes the old TAVI leaflets against the stent which becomes covered up to the top of the jailed leaflets. This, together with stent frame overlapping, may jeopardize coronary access. We sought to investigate this through a post-TAVI computed tomography (CT)
Published: 2018

33. Hypertrophic Left Ventricle With Small Cavity and Severe Aortic Angulation

Author: Alessandro Castiglioni, Damiano Regazzoli, Daisuke Hachinohe, Paolo Del Sole, Fabrizio Monaco, Matteo Montorfano, Azeem Latib, Antonio Colombo, Francesco Giannini, Vittorio Romano, Antonio Mangieri, Marco Ancona, Francesco Ancona, and Antonio Esposito
Subjects: medicine.medical_specialty, Transcatheter aortic, business.industry, medicine.medical_treatment, Perforation (oil well), Stroke volume, 030204 cardiovascular system & hematology, medicine.disease, 03 medical and health sciences, Stenosis, 0302 clinical medicine, medicine.anatomical_structure, Aortic valve area, Valve replacement, Ventricle, Heart failure, Internal medicine, cardiovascular system, medicine, Cardiology, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business
Abstract: An 87-year-old woman presented with worsening symptoms of heart failure. Echocardiography revealed paradoxical low-flow aortic stenosis (mean gradient 34 mm Hg; aortic valve area 0.9 cm2, indexed stroke volume 31 ml/m2) together with small left ventricular (LV) cavity and septal hypertrophy. The
Published: 2018

34. TCT-615 Impact of Mitral Annular Calcification on Clinical Outcomes after Transcatheter Aortic Valve Implantation

Author: Akihito Tanaka, Azeem Latib, Francesco Ancona, Matteo Montorfano, Antonio Colombo, Francesco Giannini, Ottavio Alfieri, Marco Ancona, Damiano Regazzoli, Eustachio Agricola, Luciano Candilio, Antonio Mangieri, Alaide Chieffo, Vittorio Romano, Richard J. Jabbour, and Manuela Giglio
Subjects: medicine.medical_specialty, Mitral annular calcification, Transcatheter aortic, business.industry, Internal medicine, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business
Published: 2017

35. Operative definition of active and healthy ageing (AHA): Meeting report. Montpellier October 20–21, 2014

Author: Carol Brayne, O. Krys, B. Samolinski, Ana Maria Carriazo, François Roubille, Joël Ankri, P. Matignon, P. Bertone, V. Traver-Salcedo, D. Poethig, Sergio Bonini, Itziar Vergara, P. Viriot-Durandal, J. Suanzes, François Puisieux, Elena Villalba-Mora, D. Kula, A. Bedbrook, Vittorio Romano, J. Touchon, Daniel Laune, J. Pelissier, L. Rodriguez Manas, G. J. Buijs, M. Criton, Marek L. Kowalski, T. Strandberg, Mai Stafford, M. Van Beurden, S. Slagter, Erik Melén, Marcus Richards, Mike Bewick, Carel Thijs, Raphaëlle Varraso, Alessandro Blasimme, A. Zaidi, Gregoire Mercier, Henriette A. Smit, S. Fernandez-Nocelo, K. Andersen Ranberg, Frédéric Cuisinier, Bruno Vellas, M. O'Neill, Claudine Berr, João O. Malva, Thomas Keil, Holger Schulz, Theodore D. Cosco, H. Blain, C. Tischer, Pierre Senesse, Emmanuelle Kesse-Guyot, Philippe-Jean Bousquet, Dirkje S. Postma, Susanne Krauss-Etschmann, Daniela Porta, Pascal Demoly, Z. Gutter, M. E. Joel, G. Moda, Claude Jeandel, I. Momas, John Farrell, Karen Ritchie, Sylvie Arnavielhe, Eveline Wouters, J. Coletta, Nick A. Guldemond, J. Bringer, Justin Michel, D. Heve, J. Garcia-Aymerich, Jordi Alonso, Jean Bousquet, Ana Todo-Bom, Dieter Maier, Jean-Marie Robine, Rachel Cooper, Diana Kuh, Guido Iaccarino, Antoine Avignon, J. Mercier, A. Hendry, Davide Caimmi, Bernard Combe, Neil Wilson, R. Pengelly, C. Robalo-Cordeiro, P. Auge, J. Venne, Rebecca Hardy, Maddalena Illario, A. Nizinkska, Alfredo Cesario, Marcel Goldberg, Sylvain Lehmann, Bertrand Fougère, Syed Hasan Arshad, A. Scott, Federico Alonso, M. Nogues, Marie Zins, Rodolphe Bourret, David Somekh, T. Camuzat, D. Harman, Valentina A. Andreeva, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Biocommunication en Cardio-Métabolique (BC2M), Université de Montpellier (UM), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, Institut d'Electronique du Solide et des Systèmes (InESS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Departamento de Biología Molecular y Celular del Cáncer (CSIC-UAM), Instituto de Investigaciones Biomédicas A. Sols, Hôpital Lapeyronie [Montpellier] (CHU), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), École des hautes études en sciences sociales (EHESS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Gérontopôle, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Paris-Est Marne-la-Vallée (UPEM), Eindhoven University of Technology [Eindhoven] (TU/e), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, IMIM-Hospital del Mar, Generalitat de Catalunya, Groupe Matrice Extracellulaire et Biomineralisation, Université Paris Descartes - Paris 5 (UPD5), GEOMAR LEGOS, Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique humaine (IGH), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Telecom Bretagne, Brest, Laboratoire de magnétisme et d'optique de Versailles (LMOV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Service de Pneumologie, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse], Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), University of Naples Federico II-CNR, Rome, Italy and Department of Medicine, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Departement de Cardiologie, Neuropsychiatrie : recherche épidémiologique et clinique, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Antoine Béclère, UMS011 Cohortes épidémiologiques en population (CONSTANCES), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), HESAM Université (HESAM)-HESAM Université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Météo-France -Institut de Recherche pour le Développement (IRD)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Météo-France -Institut de Recherche pour le Développement (IRD)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPC), Epidemiologie, RS: CAPHRI School for Public Health and Primary Care, RS: CAPHRI - R5 - Optimising Patient Care, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] ( PhyMedExp ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de pharmacologie et innovation dans le diabète ( CPID ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Centre National de la Recherche Scientifique ( CNRS ), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon ( MACVIA-LR ), Université Montpellier 1 ( UM1 ) -World Health Organization ( WHO/OMS ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -European Innovation Partnership on Active and Healthy Ageing Reference Site, Medical University of Warsaw-Faculté de Pharmacie de Paris, CNR, Rome, Italy and Department of Medicine-Second University of Naples, Institut d'Electronique du Solide et des Systèmes ( InESS ), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS ), Departamento de Biología Molecular y Celular del Cáncer ( CSIC-UAM ), Hôpital Lapeyronie [Montpellier] ( CHU ), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle ( CRESS - U1153 ), Université Paris 13 ( UP13 ) -Institut National de la Recherche Agronomique ( INRA ) -Conservatoire National des Arts et Métiers [CNAM] ( CNAM ) -Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ), Gerontopole of Toulouse, CHU- Université de Toulouse, Université Paris-Est Marne-la-Vallée ( UPEM ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Eindhoven University of Technology [Eindhoven] ( TU/e ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Arnaud de Villeneuve, Université Paris Descartes - Paris 5 ( UPD5 ), Laboratoire d'études en Géophysique et océanographie spatiales ( LEGOS ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Centre National d'Etudes Spatiales ( CNES ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Paul Sabatier - Toulouse 3 ( UPS ) -Centre National d'Etudes Spatiales ( CNES ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherche en Infectiologie de Montpellier ( IRIM ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ), Institut de génétique humaine ( IGH ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire AIM, Université Paris Diderot - Paris 7 ( UPD7 ) -Centre d'Etudes de Saclay, Laboratoire de magnétisme et d'optique de Versailles ( LMOV ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Centre National de la Recherche Scientifique ( CNRS ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Space Science Division, Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Antoine Béclère, UMS11 Cohortes en population, Institut National de la Santé et de la Recherche Médicale ( INSERM ), Groningen Research Institute for Asthma and COPD (GRIAC), Bousquet, J., Kuh, D., Bewick, M., Strandberg, T., Farrell, J., Pengelly, R., Joel, M. E., Rodriguez Manas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M. L., Samolinski, B., Bonini, S., Brayne, C., Michel, J. P., Venne, J., Viriot-Durandal, P., Alonso, J., Avignon, A., Bousquet, P. J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse-Guyot, E., Momas, I., Ritchie, K., Robine, J. M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Andersen Ranberg, K., Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, S. H., Auge, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G. J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez-Nocelo, S., Fougere, B., Garcia-Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeandel, C., Krauss-Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., Ogneill, M., Pelissier, J. Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo-Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H. A., Somekh, D., Stafford, M., Suanzes, J., Todo-Bom, A., Touchon, J., Traver-Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba-Mora, E., Wilson, N., Wouters, E., and Zins, M.
Subjects: Gerontology, LANGUEDOC-ROUSSILLON, Reference site, EUROPEAN INNOVATION PARTNERSHIP, [SDV]Life Sciences [q-bio], Population, and Healthy Ageing, 03 medical and health sciences, MACVIA-LR, active and healthy ageing, 0302 clinical medicine, Quality of life (healthcare), Medicine, media_common.cataloged_instance, definition, 030212 general & internal medicine, European union, education, ComputingMilieux_MISCELLANEOUS, media_common, education.field_of_study, [ SDV ] Life Sciences [q-bio], Operational definition, business.industry, MACVIA LR, EIP, european innovation partnership on active and healthy ageing, Noncommunicable disease, General partnership, Healthy ageing, Geriatrics and Gerontology, business, Active and Healthy Ageing, Definition, European Innovation Partnership on Active, 030217 neurology & neurosurgery
Abstract: International audience; The broad concept of Active and Healthy Ageing was proposed by WHO as the process of optimizing opportunities for health to enhance quality of life as people age. It applies to both individuals and population groups. A universal active and healthy ageing definition is not available and may differ depending on the purpose of the definition and/or the questions raised. The European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) has had a major impact but a definition of Active and Healthy Ageing is urgently needed. A meeting was organised in Montpellier October 20-21, 2014 as the annual conference of the EIP on AHA Reference Site MACVIA-LR (contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc Roussillon). The goal of the meeting was to propose an operational definition of Active and Healthy Ageing as well as tools that may be used for this definition. The current paper provides a summary of the plenary presentations that were given during the meeting.
Published: 2015

36. Use of double stiff wire allows successful transfemoral transcatheter aortic valve implantation through extreme thoracic aorta tortuosity

Author: Neil Ruparelia, Antonio Colombo, Ottavio Alfieri, Nicola Buzzatti, Antonio Mangieri, Matteo Montorfano, Linda Cota, Vittorio Romano, Buzzatti, N, Mangieri, A, Cota, L, Ruparelia, N, Romano, V, Alfieri, Ottavio, Colombo, A, and Montorfano, M.
Subjects: Aortic valve, Male, medicine.medical_specialty, Catheters, Aorta, Thoracic, Aortography, Transcatheter Aortic Valve Replacement, Electrocardiography, Internal medicine, medicine.artery, medicine, Thoracic aorta, Humans, Cardiac skeleton, Aged, 80 and over, Ejection fraction, business.industry, EuroSCORE, Aortic Valve Stenosis, medicine.disease, Surgery, Femoral Artery, Stenosis, medicine.anatomical_structure, Treatment Outcome, Cardiology, Transthoracic echocardiogram, Cardiology and Cardiovascular Medicine, Complication, business
Abstract: An 80-year-old man affected by symptomatic (New York Heart Association III) aortic stenosis was referred to our center. Transthoracic echocardiogram showed low-flow low-gradient aortic stenosis (mean gradient 30 mm Hg, valve area 0.6 cm2, ejection fraction 35%). His past medical history included liver cirrhosis in chronic hepatitis C infection (Child-Pugh A6) and severe osteoporosis with chest deformation and restrictive pulmonary disease. His EuroSCORE was 15.4% and Society of Thoracic Surgeons score was 4.8%. Preoperative computed tomography revealed significant tortuosity of the descending thoracic aorta, with a double curve (Figure 1A–1C; Movie I in the Data Supplement) and a narrowest lumen diameter of 18 mm. Significant kinking was also present at the level of the right femoro-iliac axis (Figure 1B) with a minimum diameter was 9.1 mm at both sides. His aortic annulus size was calculated at 25×27 mm (area 540 mm2). After Heart Team discussion, in view of his multiple comorbidites, he was submitted to transcathter aortic valve implantation. Transfemoral route was deemed the most suitable access route because of the presence of restrictive pulmonary disease and increased associated risk with …
Published: 2015

37. Transfemoral transcatheter aortic valve implantation in patients with small diseased peripheral vessels

Author: Azeem Latib, Hiroyoshi Kawamoto, Tadashi Miyazaki, Pietro Spagnolo, Antonio Colombo, Matteo Longoni, Matteo Montorfano, Neil Ruparelia, Ottavio Alfieri, Vittorio Romano, Fillipo Figini, Nicola Buzzatti, Ruparelia, N, Buzzatti, N, Romano, V, Longoni, M, Figini, F, Montorfano, M, Kawamoto, H, Miyazaki, T, Spagnolo, P, Alfieri, Ottavio, Colombo, A, and Latib, A.
Subjects: Male, medicine.medical_specialty, medicine.medical_treatment, Embolectomy, Balloon, Iliac Artery, Transcatheter Aortic Valve Replacement, Peripheral Arterial Disease, medicine, Humans, Aged, Ultrasonography, Vascular disease, business.industry, General Medicine, Aortic Valve Stenosis, medicine.disease, Surgery, Peripheral, Femoral Artery, Catheter, medicine.anatomical_structure, Treatment Outcome, Aortic Valve, Feasibility Studies, Female, Radiology, Cardiology and Cardiovascular Medicine, Complication, business, Tomography, X-Ray Computed, Artery, Calcification, Follow-Up Studies
Abstract: Objectives The aim of this study was to assess the feasibility, safety and short-term outcomes of transfemoral transcatheter aortic valve implantation (TF-TAVI) in patients with small diseased peripheral vessels. Background The transfemoral (TF) route for transcatheter aortic valve (TAVI) is the default option due to associated advantages. However, this is limited due to the high prevalence of significant peripheral arterial disease and increased risk of vascular complications. Methods Of 539 consecutive patients undergoing TAVI in a single Italian center, 23 patients underwent TF-TAVI in the presence of small peripheral vessels as defined by a minimal luminal diameter (MLD) of ≤5.5mm [by computed tomography (CT)] and/or the inability to advance a large-bore sheath. Calcification was defined as being concentric if calcium extended more than 270° around the circumference of the artery. All patients underwent 30-day clinical follow-up. Results 17 (73.9%) patients underwent peripheral vessel pre-dilatation with a semi-compliant balloon and 6 (26.1%) patients with a Solopath sheath. 6 (26.1%) patients suffered a peri-procedural complication, with 1 patient requiring surgical embolectomy for thrombotic occlusion and the remaining patients successfully managed percutaneously in the catheter laboratory. No patient suffered a vessel perforation or required implantation of a covered stent. At 30-day follow-up, all patients were free of symptoms and signs or symptoms of peripheral vascular disease, with well-functioning TAVI prostheses as evaluated by echocardiography. Conclusions Performing TF-TAVI is feasible in patients with no other viable vascular access option in the presence of small MLD and calcification of the peripheral vasculature, with any anticipated acute vascular complication managed in the catheter laboratory with established percutaneous techniques.
Published: 2015

38. A Novel Technique for Prosthetic Valve Retrieval After Transcatheter Aortic Valve Embolization

Author: Luciano Candilio, Francesco Ancona, Cosmo Godino, Richard J. Jabbour, Neil Ruparelia, Damiano Regazzoli, Antonio Colombo, Vittorio Romano, Matteo Montorfano, Azeem Latib, Marco Ancona, Antonio Mangieri, Francesco Giannini, Francesca Del Furia, Giannini, Francesco, Ruparelia, Neil, Del Furia, Francesca, Romano, Vittorio, Ancona, Marco, Mangieri, Antonio, Regazzoli, Damiano, Latib, Azeem, Godino, Cosmo, Ancona, Francesco, Candilio, Luciano, Jabbour, Richard, Colombo, Antonio, and Montorfano, Matteo
Subjects: Reoperation, Novel technique, medicine.medical_specialty, Transcatheter aortic, medicine.medical_treatment, Diastole, 030204 cardiovascular system & hematology, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Left coronary artery, Internal medicine, medicine.artery, medicine, Cardiac Surgical Procedure, Humans, 030212 general & internal medicine, Embolization, Cardiac Surgical Procedures, Device Removal, Aged, 80 and over, Prosthetic valve, business.industry, Aortic Valve Stenosis, Aortic Valve Stenosi, Embolization, Therapeutic, Prosthesis Failure, Surgery, Heart Valve Prosthesi, Heart Valve Prosthesis, Cardiology, Female, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business, Complication, Perfusion, Echocardiography, Transesophageal, Human
Abstract: Although the rate of procedural complications during transcatheter aortic valve implantation has decreased because of technological advancement and increased operator experience, device embolization remains a rare but potentially fatal complication, even with new generation devices. We report, to our knowledge, the first case of Portico valve (St Jude Medical, Minneapolis, MN) migration despite apparent optimal initial implantation depth, which was retrieved using a novel strategy after failure of a traditional retrieval technique. We also describe a mechanism of left coronary artery systolic perfusion with diastolic backflow, which led to myocardial ischemia.
Published: 2017

39. Relation between growth dynamics and diffusional limitations inSaccharomyces cerevisiaecells growing as entrapped in an insolubilised gelatin gel

Author: Danilo Porro, Vittorio Romano, Elisabetta de Alteriis, Palma Parascandola, de Alteriis, E, Porro, D, Romano, V, Parascandola, P, DE ALTERIIS, Elisabetta, Porro, D., Romano, V., and Parascandola, P.
Subjects: Saccharomyces cerevisiae, Population, Saccharomyces cerevisiae, Flow citometry, growth dynamics, Microbiology, Flow cytometry, Diffusion, Fungal Proteins, Matrix (chemical analysis), Gelatin gel, Genetics, medicine, Biomass, education, Molecular Biology, education.field_of_study, medicine.diagnostic_test, biology, Dynamics (mechanics), Cells, Immobilized, Flow Cytometry, biology.organism_classification, Yeast, Culture Media, Glucose, Biochemistry, Gelatin matrix, Biophysics, Gelatin, Gels
Abstract: Flow-cytometric analysis was employed to investigate growth dynamics of a yeast cell population immobilised in an insolubilised gelatin gel by means of the quantitative determination of the average protein content per cell. This analysis was carried out on both the immobilised cell population considered as a whole and the subpopulations colonising the gelatin matrix at different depths. The results show that growth of the gelatin-immobilised yeast population was affected by the existence of a gradient of nutrient concentrations through the matrix and are in agreement with the unsteady-state diffusion model employed for the description of glucose transfer in the gel.
Published: 2001

40. TCT-698 Comparison of the fully repositionable and retrievable Lotus Valve and Direct Flow Medical Valve for the treatment of severe aortic stenosis: a high-volume single center experience

Author: Andrea Aurelio, Akihito Tanaka, Azeem Latib, Neil Ruparelia, Vittorio Romano, Ottavio Alfieri, Luca A. Ferri, Damiano Regazzoli, Antonio Colombo, Eustachio Agricola, Antonio Mangieri, Matteo Montorfano, Francesco Giannini, Richard J. Jabbour, Alaide Chieffo, Marco Ancona, and Matteo Longoni
Subjects: medicine.medical_specialty, Transcatheter aortic, business.industry, medicine.medical_treatment, 030204 cardiovascular system & hematology, medicine.disease, Single Center, First generation, Direct flow, Surgery, 03 medical and health sciences, Stenosis, 0302 clinical medicine, Valve replacement, medicine, Paravalvular leak, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, Volume (compression)
Abstract: A limitation of first generation transcatheter aortic valve replacement (TAVR) devices was the occurrence of paravalvular leak (PVL) that when greater than mild has been demonstrated to a predictor of mortality. Second generation devices have been designed to reduce this. One technological advance
Published: 2016

41. Percutaneous treatment of an iatrogenic aorta-to-right atrium fistula

Author: Neil Ruparelia, Matteo Montorfano, Antonio Colombo, Eustachio Agricola, Romano Vittorio, Rachele Contri, Ruparelia, Neil, Contri, Rachele, Agricola, Eustachio, Vittorio, Romano, Montorfano, Matteo, and Colombo, Antonio
Subjects: Male, medicine.medical_specialty, Cardiac Catheterization, Percutaneous, Fistula, Intraoperative Complication, medicine.medical_treatment, Iatrogenic Disease, Comorbidity, Risk Assessment, Follow-Up Studie, medicine.artery, medicine, Humans, Heart Atria, Intraoperative Complications, Aorta, Cardiac catheterization, Aged, Heart Valve Prosthesis Implantation, Vascular Fistula, Interventional cardiology, business.industry, Mitral Valve Insufficiency, General Medicine, medicine.disease, Surgery, Radiography, medicine.anatomical_structure, Treatment Outcome, Echocardiography, Right atrium, Radiology, Complication, business, Cardiology and Cardiovascular Medicine, Transseptal puncture, Human, Follow-Up Studies
Abstract: • Transseptal puncture is commonly performed in both interventional cardiology and electrophysiology procedures, however complications occur in approximately 1% of cases.
Published: 2015

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