476 results on '"Yogo, A."'
Search Results
2. High-performance glass filters for capturing and culturing circulating tumor cells and cancer-associated fibroblasts
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Hiromasa Tanaka, Daijiro Iwata, Yuki Shibata, Tetsunari Hase, Daisuke Onoshima, Naoyuki Yogo, Hirofumi Shibata, Mitsuo Sato, Kenji Ishikawa, Ikuo Nagasawa, Yoshinori Hasegawa, Makoto Ishii, Yoshinobu Baba, and Masaru Hori
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Medicine ,Science - Abstract
Abstract Various liquid biopsy methods have been developed for the non-invasive and early detection of diseases. In particular, the detection of circulating tumor cells (CTCs) and cancer-associated fibroblasts (CAFs) in blood has been receiving a great deal of attention. We have been developing systems and materials to facilitate such liquid biopsies. In this study, we further developed glass filters (with various patterns of holes, pitches, and non-adhesive coating) that can capture CTCs, but not white blood cells. We optimized the glass filters to capture CTCs, and demonstrated that they could be used to detect CTCs from lung cancer patients. We also used the optimized glass filters for detecting CAFs. Additionally, we further developed a system for visualizing the captured cells on the glass filters. Finally, we demonstrated that we could directly culture the captured cells on the glass filters. Based on these results, our high-performance glass filters appear to be useful for capturing and culturing CTCs and CAFs for further examinations.
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- 2023
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3. Super-strong magnetic field-dominated ion beam dynamics in focusing plasma devices
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A. Morace, Y. Abe, J. J. Honrubia, N. Iwata, Y. Arikawa, Y. Nakata, T. Johzaki, A. Yogo, Y. Sentoku, K. Mima, T. Ma, D. Mariscal, H. Sakagami, T. Norimatsu, K. Tsubakimoto, J. Kawanaka, S. Tokita, N. Miyanaga, H. Shiraga, Y. Sakawa, M. Nakai, H. Azechi, S. Fujioka, and R. Kodama
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Medicine ,Science - Abstract
Abstract High energy density physics is the field of physics dedicated to the study of matter and plasmas in extreme conditions of temperature, densities and pressures. It encompasses multiple disciplines such as material science, planetary science, laboratory and astrophysical plasma science. For the latter, high energy density states can be accompanied by extreme radiation environments and super-strong magnetic fields. The creation of high energy density states in the laboratory consists in concentrating/depositing large amounts of energy in a reduced mass, typically solid material sample or dense plasma, over a time shorter than the typical timescales of heat conduction and hydrodynamic expansion. Laser-generated, high current–density ion beams constitute an important tool for the creation of high energy density states in the laboratory. Focusing plasma devices, such as cone-targets are necessary in order to focus and direct these intense beams towards the heating sample or dense plasma, while protecting the proton generation foil from the harsh environments typical of an integrated high-power laser experiment. A full understanding of the ion beam dynamics in focusing devices is therefore necessary in order to properly design and interpret the numerous experiments in the field. In this work, we report a detailed investigation of large-scale, kilojoule-class laser-generated ion beam dynamics in focusing devices and we demonstrate that high-brilliance ion beams compress magnetic fields to amplitudes exceeding tens of kilo-Tesla, which in turn play a dominant role in the focusing process, resulting either in a worsening or enhancement of focusing capabilities depending on the target geometry.
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- 2022
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4. Time–frequency analysis of serum with proton nuclear magnetic resonance for diagnosis of pancreatic cancer
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Asahi Sato, Toshihiko Masui, Akitada Yogo, Takashi Ito, Keiko Hirakawa, Yoshimasa Kanawaku, Kaoru Koike, and Shinji Uemoto
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Medicine ,Science - Abstract
Abstract Although serum markers such as carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) have been widely used in screening for pancreatic cancer (PC), their sensitivity and specificity are unsatisfactory. Recently, a novel tool of analyzing serum using the short-time Fourier transform (STFT) of free induction decays (FIDs) obtained by 1H-NMR has been introduced. We for the first time evaluated the utility of this technology as a diagnostic tool for PC. Serum was obtained from PC patients before starting any treatments. Samples taken from individuals with benign diseases or donors for liver transplantation were obtained as controls. Serum samples from both groups underwent 1H-NMR and STFT of FIDs. STFT data were analyzed by partial least squares discriminant analysis (PLS-DA) to clarify whether differences were apparent between groups. As a result, PLS-DA score plots indicated that STFT of FIDs enabled effective classification of groups with and without PC. Additionally, in a subgroup of PC, long-term survivors (≥ 2 years) could be discriminated from short-term survivors (
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- 2020
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5. Author Correction: Proof-of-principle experiment for laser-driven cold neutron source
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S. R. Mirfayzi, A. Yogo, Z. Lan, T. Ishimoto, A. Iwamoto, M. Nagata, M. Nakai, Y. Arikawa, Y. Abe, D. Golovin, Y. Honoki, T. Mori, K. Okamoto, S. Shokita, D. Neely, S. Fujioka, K. Mima, H. Nishimura, S. Kar, and R. Kodama
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Medicine ,Science - Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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- 2021
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6. Development of an immuno-wall device for the rapid and sensitive detection of EGFR mutations in tumor tissues resected from lung cancer patients.
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Naoyuki Yogo, Tetsunari Hase, Toshihiro Kasama, Keine Nishiyama, Naoya Ozawa, Takahiro Hatta, Hirofumi Shibata, Mitsuo Sato, Kazuki Komeda, Nozomi Kawabe, Kohei Matsuoka, Toyofumi Fengshi Chen-Yoshikawa, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba, and Yoshinori Hasegawa
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Medicine ,Science - Abstract
Detecting molecular targets in specimens from patients with lung cancer is essential for targeted therapy. Recently, we developed a highly sensitive, rapid-detection device (an immuno-wall device) that utilizes photoreactive polyvinyl alcohol immobilized with antibodies against a target protein via a streptavidin-biotin interaction. To evaluate its performance, we assayed epidermal growth factor receptor (EGFR) mutations, such as E746_A750 deletion in exon 19 or L858R substitution in exon 21, both of which are common in non-small cell lung cancer and important predictors of the treatment efficacy of EGFR tyrosine kinase inhibitors. The results showed that in 20-min assays, the devices detected as few as 1% (E746_A750 deletion) and 0.1% (L858R substitution) of mutant cells. Subsequent evaluation of detection of the mutations in surgically resected lung cancer specimens from patients with or without EGFR mutations and previously diagnosed using commercially available, clinically approved genotyping assays revealed diagnostic sensitivities of the immuno-wall device for E746_A750 deletion and L858R substitution of 85.7% and 87.5%, respectively, with specificities of 100% for both mutations. These results suggest that the immuno-wall device represents a good candidate next-generation diagnostic tool, especially for screening of EGFR mutations.
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- 2020
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7. Simplified Clinical Decision Rule Using Clinically Important Events for Risk Prediction in Pediatric Head Injury: A Retrospective Cohort Study
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Naoki Yogo, Chiaki Toida, Takashi Muguruma, Masayasu Gakumazawa, Mafumi Shinohara, and Ichiro Takeuchi
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pediatrics ,emergency department ,clinically important traumatic brain injury ,Medicine - Abstract
Computed tomography (CT) scans are useful for confirming head injury diagnoses. However, there is no standard clinical decision rule (CDR) for determining the need for CT scanning in pediatric patients with head injuries. We developed a CDR and conducted a retrospective cohort study to evaluate its diagnostic accuracy in identifying children with clinically important traumatic brain injury (ciTBI). We selected predictors based on three existing CDRs: CATCH, CHALICE, and PECARN. Of the 2569 eligible patients, 645 (439 (68%) boys, median age: five years) were included in this study. In total, 59 (9%) patients showed ciTBI, and 129 (20%) were admitted to hospital. The novel CDR comprised six predictors of abnormal CT findings. It had a sensitivity of 79.5% (95% confidence interval (CI): 65.5–89.0%) and a specificity of 50.9% (95% CI: 48.9–52.3%). The area under the receiver-operating characteristic curve (0.72, 95% CI: 0.67–0.77) was non-inferior to those of CATCH, CHALICE, and PECARN (0.71, 95% CI: 0.66–0.77; 0.67, 95% CI: 0.61–0.74; and 0.69, 95% CI: 0.64–0.73, respectively; p = 0.57). The novel CDR was statistically noninferior in diagnostic accuracy compared to the three existing CDRs. Further development and validation studies are needed before clinical application.
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- 2021
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8. Control of unsteady laser-produced plasma-flow with a multiple-coil magnetic nozzle
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Taichi Morita, Masafumi Edamoto, Satoshi Miura, Atsushi Sunahara, Naoya Saito, Yutaro Itadani, Tomihiko Kojima, Yoshitaka Mori, Tomoyuki Johzaki, Yoshihiro Kajimura, Shinsuke Fujioka, Akifumi Yogo, Hiroaki Nishimura, Hideki Nakashima, and Naoji Yamamoto
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Medicine ,Science - Abstract
Abstract We report an experimental demonstration of controlling plasma flow direction with a magnetic nozzle consisting of multiple coils. Four coils are controlled separately to form an asymmetric magnetic field to change the direction of laser-produced plasma flow. The ablation plasma deforms the topology of the external magnetic field, forming a magnetic cavity inside and compressing the field outside. The compressed magnetic field pushes the plasma via the Lorentz force on a diamagnetic current: j × B in a certain direction, depending on the magnetic field configuration. Plasma and magnetic field structure formations depending on the initial magnetic field were simultaneously measured with a self-emission gated optical imager and B-dot probe, respectively, and the probe measurement clearly shows the difference of plasma expansion direction between symmetric and asymmetric initial magnetic fields. The combination of two-dimensional radiation hydrodynamic and three-dimensional hybrid simulations shows the control of the deflection angle with different number of coils, forming a plasma structure similar to that observed in the experiment.
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- 2017
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9. Mesoscopic Multimodal Imaging Provides New Insight to Tumor Tissue Evaluation: An Example of Macrophage Imaging of Hepatic Tumor using Organosilica Nanoparticles
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Michihiro Nakamura, Koichiro Hayashi, Hitoshi Kubo, Masafumi Harada, Keisuke Izumi, Yoshihiro Tsuruo, and Toshinobu Yogo
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Medicine ,Science - Abstract
Abstract Multimodal imaging using novel multifunctional nanoparticles provides new approach to biomedical field. Thiol-organosilica nanoparticles containing iron oxide magnetic nanoparticles (MNPs) and rhodamine B (thiol OS-MNP/Rho) were applied to multimodal imaging of hepatic tumor of Long−Evans Cinnamon (LEC) rat. The magnetic resonance imaging (MRI) of LEC rats revealed tumors in the liver clearly and semi-quantitatively due to a labeling of macrophages in liver. The fluorescent imaging (FI) showed abnormal fluorescent patterns of the liver at the mesoscopic level that was between macroscopic and microscopic level. We performed correlation analysis between optical imaging including FI and MRI. We found that the labeled macrophages located specific area in the tumor tissue and influenced the tumor size on MRI. In addition histological observation showed the labeled macrophages related specific tissue in the pathological region. We demonstrated a new approach to evaluate tumor tissue at the macroscopic and microscopic level as well as mesoscopic level using multimodal imaging.
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- 2017
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10. TECHNICAL INDICATORS OF CARDIO-PULMONARY RESUSCITATION (CPR) WITH TRAVELING TIME 20, 40 AND 60 KM/H
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Yogo Apriyanto, Nursalam Nursalam, and Arie Sunarno
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Travelling Time, Technical Indicators of CPR, Ambulances 118 ,Medicine ,Nursing ,RT1-120 - Abstract
Introduction: Ambulances had special rule of velocity. Ambulances could accelerate over 80 km/h and could break through traffic light. During transport the patient might be got cardiac arrest. Almost all of the pre hospital nurses had reported that doing CPR during transport was difficult. The objective of this study was to analyze the effect of traveling time 20 km/h, 40 km/h and 60 km/h on technical indicators of CPR. Method: Design used in this study was pre-experiment. The population were nurses in ambulances 118 of Dr. Soetomo hospital Surabaya. A total of 14 respondents were taken as samples by purposive sampling. The independent variable was effectiveness of traveling time, while the dependent variable were technical indicators of CPR: Tidal Volume (TV), landmark hand position, deep of chest compression and chest compression rhythm in manekin. Data were measured by observation sheet and then analyzed using Chi-square test with level of significance α ≤ 0.05. Result: The result showed that travelling time 20 km/h and 40 km/h had a significant effect on technical indicators of CPR, but not at 60 km/h. Discussion: It could be concluded, the faster the travelling time, the more difficult to perform CPR. Further study should involve the travelling time and the accuracy of CPR technical indicators to treat and safe the patients, either in traumatic or non traumatic case.
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- 2017
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11. Assessing drug target suitability using TargetMine [version 2; peer review: 2 approved]
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Yi-An Chen, Erika Yogo, Naoko Kurihara, Tomoshige Ohno, Chihiro Higuchi, Masatomo Rokushima, and Kenji Mizuguchi
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Medicine ,Science - Abstract
In selecting drug target candidates for pharmaceutical research, the linkage to disease and the tractability of the target are two important factors that can ultimately determine the drug efficacy. Several existing resources can provide gene-disease associations, but determining whether such a list of genes are attractive drug targets often requires further information gathering and analysis. In addition, few resources provide the information required to evaluate the tractability of a target. To address these issues, we have updated TargetMine, a data warehouse for assisting target prioritization, by integrating new data sources for gene-disease associations and enhancing functionalities for target assessment. As a data mining platform that integrates a variety of data sources, including protein structures and chemical compounds, TargetMine now offers a powerful and flexible interface for constructing queries to check genetic evidence, tractability and other relevant features for the candidate genes. We demonstrate these features by using several specific examples.
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- 2019
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12. Assessing drug target suitability using TargetMine [version 1; peer review: 2 approved]
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Yi-An Chen, Erika Yogo, Naoko Kurihara, Tomoshige Ohno, Chihiro Higuchi, Masatomo Rokushima, and Kenji Mizuguchi
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Medicine ,Science - Abstract
In selecting drug target candidates for pharmaceutical research, the linkage to disease and the tractability of the target are two important factors that can ultimately determine the drug efficacy. Several existing resources can provide gene-disease associations, but determining whether such a list of genes are attractive drug targets often requires further information gathering and analysis. In addition, few resources provide the information required to evaluate the tractability of a target. To address these issues, we have updated TargetMine, a data warehouse for assisting target prioritization, by integrating new data sources for gene-disease associations and enhancing functionalities for target assessment. As a data mining platform that integrates a variety of data sources, including protein structures and chemical compounds, TargetMine now offers a powerful and flexible interface for constructing queries to check genetic evidence, tractability and other relevant features for the candidate genes. We demonstrate these features by using several specific examples.
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- 2019
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13. Effects of establishing a trauma center on the mortality rate among injured pediatric patients in Japan.
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Takashi Muguruma, Chiaki Toida, Masayasu Gakumazawa, Naoki Yogo, Mafumi Shinohara, and Ichiro Takeuchi
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Medicine ,Science - Abstract
INTRODUCTION:It remains unclear whether trauma centers are effective for the treatment of injured pediatric patients. The aim of this study was to evaluate children's mortality before and after the establishment a trauma center by using standard mortality ratios (SMR) and a modified observed-expected chart. METHODS:This was a single center, retrospective chart review study that included injured pediatric patients (age
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- 2019
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14. Safety, immunogenicity, and efficacy of a COVID-19 vaccine (NVX-CoV2373) co-administered with seasonal influenza vaccines: an exploratory substudy of a randomised, observer-blinded, placebo-controlled, phase 3 trial
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Seth Toback, Eva Galiza, Catherine Cosgrove, James Galloway, Anna L Goodman, Pauline A Swift, Sankarasubramanian Rajaram, Alison Graves-Jones, Jonathan Edelman, Fiona Burns, Angela M Minassian, Iksung Cho, Lakshmi Kumar, Joyce S Plested, E Joy Rivers, Andreana Robertson, Filip Dubovsky, Greg Glenn, Paul T Heath, Roy L. Soiza, Robin Brittain-Long, Chiara Scicluna, Carole Edwards, Lynn Mackay, Mariella D'Allesandro, Amy Nicol, Karen Norris, Sandra Mann, Heather Lawrence, Ruth Valentine, Marianne Elizabeth Viljoen, Carol H. Pretswell, Helen Nicholls, Imrozia Munsoor, Agnieszka Meyrick, Christina Kyriakidou, Shalini Iyengar, Arham Jamal, Nick Richards, Helen Price, Bridie Rowbotham, Danielle Bird, Karen Smith, Olga Littler, Kirsty Fielding, Anna Townsend-Rose, Karen Miller, Jessica Davis, Alison Elliot-Garwood, Lauren Trottier, Paul Edwards, Margaret McFarland, Orod Osanlou, Laura Longshaw, Jane Stockport, Lynne Grundy, Katharine Lucy Broad, Karen Regan, Kim Storton, Declan Ryan-Wakeling, Brad Wilson, Malathy Munisamy, John Wright, Anil Shenoy, Beverley English, Lucy Brear, Paola Cicconi, Marta Boffito, Ana Milinkovic, Ruth Byrne, Roya Movahedi, Rosalie Housman, Naveed Kara, Ellen Brown, Andrea Cipriani, Mary-Jane Attenburrow, Katharine A. Smith, Jonathan Packham, Geoff Sparrow, Richard Smith, Josephine M. Rosier, Khalid Saja, Nyasha Nago, Brian Camilleri, Anita Immanuel, Mike Hamblin, Rawlings Osagie, Mahalakshmi Mohan, Hilary Floyd, Suzanne Goddard, Sanjay Mutgi, John Evans, Sean McKeon, Neringa Vilimiene, Rosavic Chicano, Rachel Hayre, Alice Pandaan, Catherine Henshall, Sonia Serrano, Andrea Mazzella, Thurkka Rajeswaran, Moncy Mathew, Karen Bisnauthsing, Laura Bremner, Henry Fok, Franca Morselli, Paola Cinardo, Blair Merrick, Lucy Sowole, Samantha Broadhead, Natalie Palmer, Jessica Cordle, Jaimie Wilson Goldsmith, Enya Cooney, Beth Jackson, Thilina Jayatilleke, Zelda Cheng, Toby Helliwell, Adrian Chudyk, Rafaela Giemza, John Lord Villajin, Noah Yogo, Esther Makanju, Pearl Dulawan, Deepak Nagra, April Buazon, Alice Russell, Georgie Bird, Amardeep Heer, Rex Sarmiento, Balraj Sanghera, Melanie Mullin, Adam Champion, Aisling Bevan, Kinzah Iqbal, Alshia Johnson, Rebecca Clark, Sarah Shaw, Steven Shaw, Amanda Chalk, Martin Lovatt, Caroline Lillicrap, Angela Parker, Jan Hansel, Zhi Wong, Galvin Gan, Eyad Tuma, Jane Minton, Jennifer Murira, Razan Saman, Alistair Hall, Kyra Holliday, Zara Khan, James Calderwood, George Twigg, Helena Baker, Julie Corrigan, Katy Houseman, Subhra Raguvanshi, Dominic Heining, Jake Weddell, Liz Glaves, Kim Thompson, Francis Davies, Ruth Lambley Burke, Emma C. Thomson, Dinesh Saralaya, Lisa Berry, Nancy Hopewell, Leigh Gerdes, Mihaela Pacurar, Saul N. Faust, Jeremy Turner, Christopher Jeanes, Adele Cooper, Jocelyn Keshet-Price, Lou Coke, Melissa Cambell-Kelly, Ketan Dhatariya, Claire Williams, Georgina Marks, James Sudbury, Lisa Rodolico, Judy Bradley, Sharon Carr, Roisin Martin, Angelina Madden, Paul Biagioni, Sonia McKenna, Alison Clinton, Maurice O'Kane, Justin Carter, Matthew Dewhurst, Bill Wetherill, Thandiwe Hoggarth, Katrina Lennon Collins, Marie Chowdhury, Adil Nathoo, Anna Heinen, Orla MacDonald, Claudia Hurducas, Liliana Cifuentes, Harjeevan Gill, Andy Gibson, Raha West, Jane Ewing, Rachel Blacow, John Haughney, Jonathan MacDonald, John Paul Seenan, Stewart Webb, Colin O'Leary, Scott Muir, Beth White, Neil Ritchie, Daniel F. McAuley, Jonathan Stewart, Mariella D'Alessandro, Nicki Lakeman, Laura Purandare, Duncan Browne, David Tucker, Peter Luck, Angharad Everden, Lisa Trembath, Michael Visick, Nick Morley, Laura Reid, Helen Chenoweth, Kirsty Maclean, Ray P. Sheridan, Tom Burden, Craig Francis Lunt, Shirley Todd, Stephanie Estcourt, Jasmine Marie Pearce, Suzanne Wilkins, Cathryn Love-Rouse, Eva Torok-Pollok, Mike Youle, Sara Madge, Danielle Solomon, Aarti Nandani, Janet M. North, Nargis Hemat, Rachel Newport, Philip A. Kalra, Chukwuma Chukwu, Olivia Wickens, Vikki O'Loughlin, Hema Mistry, Louise Harrison, Robert Oliver, Anne-Marie Peers, Jess Zadik, Katie Doyle, David R. Chadwick, Kerry Colling, Caroline Wroe, Marie Branch, Alison Chilvers, Sarah Essex, Mark Stone, Alberto San Francisco Ramos, Emily Beales, Olivia Bird, Zsofia Danos, Hazel Fofie, Cecilia Hultin, Sabina Ikram, Fran Mabesa, Aoife Mescall, Josyanne Pereira, Jennifer Pearce, Natalina Sutton, Emma Snashall, David Neil Baxter, Sara Bennett, Debbie Suggitt, Kerry Hughes, Wiesia Woodyatt, Lynsey Beacon, Alissa Kent, Chris Cooper, Milan Rudic, Simon Tunstall, Matthew Jackson, Claire Hombersley, Patrick Moore, Rebecca Cutts, Andrew Higham, Marwan Bukhari, Mohamed Elnaggar, Michelle Glover, Fiona Richardson, Alexandra Dent, Shahzeb Mirza, Rajiv Ark, Jennie Han, Suzy V. Hope, Philip J. Mitchelmore, Rostam Osanlou, Andrew Freedman, Alison Cooper, Katherine Burton, Kashyap Katechia, Michael Barrett, Jo Salkeld, Natalie Hill, Nathaniel Lee, Jon Perkins, and Polly Fox
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Adult ,Pulmonary and Respiratory Medicine ,Trivalent influenza vaccine ,medicine.medical_specialty ,COVID-19 Vaccines ,Adolescent ,Influenza vaccine ,Population ,Placebo ,Young Adult ,Immunogenicity, Vaccine ,Double-Blind Method ,Internal medicine ,Humans ,Medicine ,education ,Adverse effect ,Aged ,education.field_of_study ,Reactogenicity ,SARS-CoV-2 ,business.industry ,COVID-19 ,Articles ,Middle Aged ,Vaccine efficacy ,Vaccination ,Influenza Vaccines ,Seasons ,business - Abstract
Background The safety and immunogenicity profile of COVID-19 vaccines when administered concomitantly with seasonal influenza vaccines have not yet been reported. We therefore aimed to report the results of a substudy within a phase 3 UK trial, by evaluating the safety, immunogenicity, and efficacy of NVX-CoV2373 when co-administered with licensed seasonal influenza vaccines. Methods We did a planned exploratory substudy as part of the randomised, observer-blinded, placebo-controlled, phase 3 trial of the safety and efficacy of the COVID-19 vaccine (NVX-CoV2373) by co-administrating the influenza vaccine at four study hospitals in the UK. Approximately, the first 400 participants meeting the main study entry criteria—with no contraindications to influenza vaccination—were invited to join the substudy. Participants of the main study were randomly assigned (1:1) to receive two intramuscular injections of either NVX-CoV2373 (5 μg) or placebo (normal saline) 21 days apart; participants enrolled into the substudy were co-vaccinated with a single (0·5 mL) intramuscular, age-appropriate (quadrivalent influenza cell-based vaccine [Flucelvax Quadrivalent; Seqirus UK, Maidenhead] for those aged 18–64 years and adjuvanted trivalent influenza vaccine [Fluad; Seqirus UK, Maidenhead] for those ≥65 years), licensed, influenza vaccine on the opposite deltoid to that of the first study vaccine dose or placebo. The influenza vaccine was administered in an open-label manner and at the same time as the first study injection. Reactogenicity was evaluated via an electronic diary for 7 days after vaccination in addition to monitoring for unsolicited adverse events, medically attended adverse events, and serious adverse events. Immunogenicity was assessed with influenza haemagglutination inhibition and SARS-CoV-2 anti-spike protein IgG assays. Vaccine efficacy against PCR-confirmed, symptomatic COVID-19 was assessed in participants who were seronegative at baseline, received both doses of study vaccine or placebo, had no major protocol deviations affecting the primary endpoint, and had no confirmed cases of symptomatic COVID-19 from the first dose until 6 days after the second dose (per-protocol efficacy population). Immunogenicity was assessed in participants who received scheduled two doses of study vaccine, had a baseline sample and at least one post-vaccination sample, and had no major protocol violations before unmasking (per-protocol immunogenicity population). Reactogenicity was analysed in all participants who received at least one dose of NVX-CoV2373 or placebo and had data collected for reactogenicity events. Safety was analysed in all participants who received at least one dose of NVX-CoV2373 or placebo. Comparisons were made between participants of the substudy and the main study (who were not co-vaccinated for influenza). This study is registered with ClinicalTrials.gov, number NCT04583995. Findings Between Sept 28, 2020, and Nov 28, 2020, a total of 15 187 participants were randomised into the main phase 3 trial, of whom 15 139 received treatment (7569 received dose one of NVX-CoV2373 and 7570 received dose one of placebo). 431 participants were co-vaccinated with a seasonal influenza vaccine in the substudy (217 received NVX-CoV2373 plus the influenza vaccine and 214 received placebo plus the influenza vaccine). In general, the substudy participants were younger, more racially diverse, and had fewer comorbid conditions than those in the main study. Reactogenicity events were more common in the co-administration group than in the NVX-CoV2373 alone group: tenderness (113 [64·9%] of 174 vs 592 [53·3%] of 1111) or pain (69 [39·7%] vs 325 [29·3%]) at injection site, fatigue (48 [27·7%] vs 215 [19·4%]), and muscle pain (49 [28·3%] vs 237 [21·4%]). Incidences of unsolicited adverse events, treatment-related medically attended adverse events, and serious adverse events were low and balanced between the co-administration group and the NVX-CoV2373 alone group. No episodes of anaphylaxis or deaths were reported within the substudy. Co-administration resulted in no change to influenza vaccine immune response although a reduction in antibody responses to the NVX-CoV2373 vaccine was noted. NVX-CoV2373 vaccine efficacy in the substudy (ie, participants aged 18 to
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- 2022
15. Interleukin-6: evolving role in the management of neuropathic pain in neuroimmunological disorders
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Kenji Yogo, Kenichi Serizawa, Shota Miyake, Yoshihiro Matsumoto, and Haruna Tomizawa-Shinohara
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medicine.medical_specialty ,Immunology ,Review ,Disease ,Neuropathic pain ,Placebo ,law.invention ,Multiple sclerosis ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Pathology ,Immunology and Allergy ,RB1-214 ,MR16-1 ,IL-6 ,Neuromyelitis optica ,Experimental autoimmune encephalomyelitis ,business.industry ,Satralizumab ,medicine.disease ,Anti–IL-6 receptor antibody ,Review article ,Neuromyelitis optica spectrum disorder ,business - Abstract
Background Neuropathic pain in neuroimmunological disorders refers to pain caused by a lesion or disease of the somatosensory system such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). MS and NMOSD are autoimmune disorders of the central nervous system, and ≥ 50% of patients with these disorders experience chronic neuropathic pain. The currently available medications for the management of neuropathic pain have limited effectiveness in patients with MS and NMOSD, and there is an unmet medical need to identify novel therapies for the management of chronic neuropathic pain in these patients. In this review article, we summarize the role of interleukin-6 (IL-6) in the pathogenesis of MS and NMOSD and the ameliorative effects of anti–IL-6 therapies in mouse models of experimental autoimmune encephalomyelitis (EAE). Main body Intraperitoneal injection of MR16-1, an anti–IL-6 receptor (IL-6R) antibody, reduced mechanical allodynia and spontaneous pain in EAE mice, which was attributed to a reduction in microglial activation and inhibition of the descending pain inhibitory system. The effect of anti–IL-6 therapies in ameliorating neuropathic pain in the clinical setting is controversial; a reduction in pain intensity has been reported with an anti–IL-6 antibody in four studies, namely a case report, a pilot study, a retrospective observational study, and a case series. Pain intensity was evaluated using a numerical rating scale (NRS), with a lower score indicating lesser pain. A reduction in the NRS score was reported in all four studies. However, in two randomized controlled trials of another anti–IL-6R antibody, the change in the visual analog scale pain score was not statistically significantly different when compared with placebo. This was attributed to the low mean pain score at baseline in both the trials and the concomitant use of medications for pain in one of the trials, which may have masked the effects of the anti–IL-6R antibody on neuropathic pain. Conclusion Thus, anti–IL-6 therapies might have a potential to reduce neuropathic pain, but further investigations are warranted to clarify the effect of inhibition of IL-6 signaling on neuropathic pain associated with MS and NMOSD.
- Published
- 2021
16. A Case of Sparganosis Caused by Spirometra decipiens on the Femur
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Shoko Yogo, Haruhiko Maruyama, Sakurako Imamura, Kazunori Urabe, Kiko Nagai, Kayo Harada, and Eiji Nagayasu
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Sparganosis ,Spirometra decipiens ,medicine ,Femur ,Dermatology ,Anatomy ,Biology ,medicine.disease - Published
- 2021
17. A Case of Anaphylactic Shock due to Hydrocortisone Sodium Succinate Suspected to Be Associated with Aspirin Asthma
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Sakurako Imamura, Shoko Yogo, Kayo Harada, and Kazunori Urabe
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business.industry ,Hydrocortisone sodium succinate ,Anaphylactic shock ,Medicine ,Dermatology ,Pharmacology ,business ,Aspirin asthma - Published
- 2021
18. SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2
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Toshihiko Masui, Shigeo Takaishi, Kenji Masuo, Ru Chen, Aiko Sugiyama, Akihisa Fukuda, Hiroshi Seno, Akitada Yogo, and Shinji Uemoto
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cancer stem cells ,Cancer Research ,Epithelial-Mesenchymal Transition ,Carcinogenesis ,pancreatic cancer ,Antineoplastic Agents ,Mice, SCID ,Cell Line ,SNAIL2 ,Cell, Molecular, and Stem Cell Biology ,Cancer stem cell ,RNA interference ,Mice, Inbred NOD ,Pancreatic cancer ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Epithelial–mesenchymal transition ,Transcription factor ,epithelial‐mesenchymal transition ,biology ,Microarray analysis techniques ,business.industry ,Gene Expression Profiling ,CD44 ,General Medicine ,Original Articles ,medicine.disease ,tumor spheroid ,Xenograft Model Antitumor Assays ,Gemcitabine ,Gene Expression Regulation, Neoplastic ,Pancreatic Neoplasms ,Insulin-Like Growth Factor Binding Protein 2 ,HEK293 Cells ,Oncology ,Drug Resistance, Neoplasm ,biology.protein ,Cancer research ,Neoplastic Stem Cells ,Original Article ,RNA Interference ,Snail Family Transcription Factors ,business ,medicine.drug - Abstract
Pancreatic cancer has an extremely poor prognosis because of its resistance to conventional therapies. Cancer stem cell (CSC)‐targeted therapy is considered a promising approach for this disease. Epithelial‐mesenchymal transition‐inducing transcription factors (EMT‐TFs) contribute to CSC properties in some solid tumors; however, this mechanism has not been fully elucidated in pancreatic cancer. Zinc finger protein, SNAIL2 (also known as SLUG), is a member of the SNAIL superfamily of EMT‐TFs and is commonly overexpressed in pancreatic cancer. Patients exhibiting high SNAIL2 expression have a poor prognosis. In this study, we showed that the suppression of SNAIL2 expression using RNA interference decreased tumorigenicity in vitro (sphere formation assay) and in vivo (xenograft assay) in 2 pancreatic cancer cell lines, KLM1 and KMP5. In addition, SNAIL2 suppression resulted in increased sensitivity to gemcitabine and reduced the expression of CD44, a pancreatic CSC marker. Moreover, experiments on tumor spheroids established from surgically resected pancreatic cancer tissues yielded similar results. A microarray analysis revealed that the mechanism was mediated by insulin‐like growth factor (IGF) binding protein 2. These results indicate that IGFBP2 regulated by SNAIL2 may represent an effective therapeutic target for pancreatic cancer., SNAIL2 knockdown reduces tumorigenicity and resistance to gemcitabine in tumor spheroid established from resected tissue of human pancreatic cancer as well as human pancreatic cancer cell lines.
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- 2021
19. Usefulness of adhesive strapping for umbilical hernias of infants
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Takahiko Oohira, Yogo Haraguchi, Yoshiko Suginohara, Eiichi Suefuji, Yuichi Miura, Kimiyasu Egami, Toshihiro Moroi, Akito Kitano, and Toshiko Kuwahara
- Subjects
medicine.medical_specialty ,030204 cardiovascular system & hematology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Pediatric Surgery ,Randomized controlled trial ,Japan ,Healing rate ,law ,030225 pediatrics ,Adhesives ,medicine ,Humans ,Observation group ,Hernia ,Prospective Studies ,Strapping ,Proportional Hazards Models ,umbilical hernia ,business.industry ,Infant ,adhesive strapping ,medicine.disease ,Umbilical hernia ,Surgery ,Log-rank test ,Pediatrics, Perinatology and Child Health ,Original Article ,Adhesive ,ORIGINAL ARTICLES ,business ,Hernia, Umbilical - Abstract
Background Using a controlled trial, this study aimed to evaluate the effectiveness of adhesive strapping to improve the natural healing rate of umbilical hernia. Methods This prospective, observational study included 128 patients from Kumamoto, Japan (97 in the adhesive strapping group, and 31 in observation group), from 2012–2015. The duration from first hospital visit to the hernia orifice closure was compared between the two groups. Result Kaplan‐Meier curves showed that the probability of umbilical hernia in the adhesive strapping group was lower until approximately 200 days, but it was not statistically significant in the log rank test. According to multivariate Cox proportional hazard models, the hazard risk of umbilical hernia in the adhesive strapping group was significantly higher within 0–60 days after adjusting for confounding factors such as hernial cavity and hernia orifice area (P < 0.0001). Conclusion Adhesive strapping of umbilical hernia was significantly associated with earlier closure of the hernia orifice from baseline until at least 60 days.
- Published
- 2021
20. Impact of vascular abnormality on contrast-enhanced CT and high C-reactive protein levels on postoperative pancreatic hemorrhage after pancreaticoduodenectomy: A multi-institutional, retrospective analysis of 590 consecutive cases
- Author
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Kenzo Nakano, Toshihiko Masui, Asahi Sato, Yuichiro Uchida, Shinji Uemoto, Kyoichi Takaori, Kazuyuki Nagai, Takayuki Anazawa, Takafumi Machimoto, Kazuki Hashida, and Akitada Yogo
- Subjects
Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Postoperative Hemorrhage ,Gastroenterology ,Pancreaticoduodenectomy ,Pancreatic Fistula ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Ascites ,medicine ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,Hepatology ,biology ,business.industry ,C-reactive protein ,Perioperative ,Odds ratio ,Middle Aged ,medicine.disease ,C-Reactive Protein ,Pancreatic fistula ,030220 oncology & carcinogenesis ,biology.protein ,Blood Vessels ,Female ,030211 gastroenterology & hepatology ,Abnormality ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Complication ,Aneurysm, False - Abstract
Background /Objectives: This study aimed to elucidate the efficacy of CT findings and perioperative characteristics to predict post-pancreatectomy hemorrhage (PPH): a critical complication after pancreaticoduodenectomy. Methods The records of 590 consecutive patients who underwent pancreaticoduodenectomy at three institutes between 2012 and 2018 were included. The presence of a vascular wall abnormality or ascites with high density (vascular abnormality) on postoperative day (POD) 5–10 contrast-enhanced CT (early CT), perioperative characteristics, and any PPH or pseudoaneurysm formation (PPH events) were analyzed through a multivariate analysis. Results PPH events occurred in 48 out of 590 patients (8%). The vascular abnormality on early CT and the C-reactive protein (CRP) value on POD 3 were independent risk factors for PPH events after POD5 (vascular abnormality: odds ratio 6.42, p = 0.001; CRP on POD 3: odds ratio 1.17, p = 0.016). The sensitivity of vascular abnormality for PPH events was 24% (7/29), and the positive predictive value was 30% (7/23). The combination of vascular abnormality and a high CRP value (≥15.5 mg/dL) on postoperative day 3 had a higher positive predictive value of 64% (7/11) than the vascular abnormality alone. None of the seven PPH events that occurred more than one month after surgery were foreseen via early CT. Conclusion The combination of vascular abnormality and high CRP value was associated with increasing risk of PPH events after pancreaticoduodenectomy, but the low sensitivity of early CT must be noted as an important shortcoming. The normal findings on early CT could not eliminate the risk of late PPH.
- Published
- 2021
21. Source position measurement by Cherenkov emission imaging from applicators for high‐dose‐rate brachytherapy
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Hiroyuki Okamoto, Kuniyasu Okudaira, Yumiko Noguchi, Hiroshi Oguchi, Hiroshi Yasuda, Hiromichi Ishiyama, Marika Nozawa, Katsunori Yogo, and Seiichi Yamamoto
- Subjects
Diagnostic Imaging ,Materials science ,medicine.medical_treatment ,Brachytherapy ,Uterine Cervical Neoplasms ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Optics ,Position (vector) ,medicine ,Humans ,Single image ,Cherenkov radiation ,Phantoms, Imaging ,business.industry ,Radiotherapy Planning, Computer-Assisted ,Device Camera ,Radiotherapy Dosage ,General Medicine ,High-Dose Rate Brachytherapy ,030220 oncology & carcinogenesis ,Female ,Light emission ,business - Abstract
Purpose We developed a novel and simple method to measure the source positions in applicators directly for high-dose-rate (HDR) brachytherapy based on Cherenkov emission imaging, and evaluated the performance. Methods The light emission from plastic applicators used in cervical cancer treatments, irradiated by an 192 Ir γ-ray source, was captured using a charge-coupled device camera. Moreover, we attached plastics of different shapes, including tapes, tubes, and plates to a metal applicator, to use as screens for the Cherenkov imaging. We determined the source positions and dwell intervals from the light profiles along with the applicator and compared these with preset values and dummy marker measurements. Results The source positions and dwell intervals measured from the light images were comparable to the dummy marker measurements and preset values. The distance from the applicator tip to the first source positions agreed with the dummy marker measurements within 0.2 mm for the plastic tandem. The dwell intervals measured using the Cherenkov method agreed with the preset values within 0.6 mm. The distances measured with three plastic types on the metal applicator also agreed with the dummy marker measurements within 0.2 mm. The dwell intervals measured using the plastic tape agreed with the preset values within 0.7 mm. Conclusions The proposed method should be suitable for rapid and easy quality assurance (QA) investigations in HDR brachytherapy, as it enables source position using a single image. The method allows for real-time, filmless measurements of the source positions to be obtained and is useful for rapid feedback in QA procedures.
- Published
- 2020
22. Left-posterior approach for artery-first en bloc resection in laparoscopic distal pancreatectomy for left-sided pancreatic cancer
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Akitada Yogo, Kazuyuki Nagai, Kyoichi Takaori, Gozo Kiguchi, Shintaro Yagi, Kojiro Taura, Takayuki Anazawa, and Toshihiko Masui
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Pancreatic Intraepithelial Neoplasia ,030230 surgery ,Splenic artery ,03 medical and health sciences ,Pancreatectomy ,0302 clinical medicine ,Mesenteric Artery, Superior ,medicine.artery ,Pancreatic cancer ,medicine ,Humans ,Superior mesenteric artery ,Pancreas ,Gastric emptying ,business.industry ,medicine.disease ,Surgery ,Pancreatic Neoplasms ,medicine.anatomical_structure ,Pancreatic fistula ,030220 oncology & carcinogenesis ,Female ,Laparoscopy ,Lymphadenectomy ,business - Abstract
We describe a “left-posterior approach” in which the important steps in laparoscopic distal pancreatectomy (LDP) for left-sided pancreatic cancer are accomplished in the direction caudal and dorsal to the pancreas. The patients who underwent LDP with a left-posterior approach at our hospital from January 2016 to April 2020 were reviewed to evaluate the short-term postoperative outcomes. In LDP, we first dissected retroperitoneal tissues above the left renal vein and superior mesenteric artery, yielding the mobilization of the pancreatic body widely. Then, the splenic artery was divided behind the ventrally lifted pancreas as an artery-first approach. The regional lymphadenectomy was performed in an en bloc manner consecutively in the same operative field. The neck of the pancreas was transected with a linear stapler after mobilization of the spleen. In nine patients (five men and four women) aged 76 years (range: 64–82 years), the operative time was 398 min (276–482 min) with the estimated blood loss of 40 ml (0–80 ml). No patients developed grade B/C pancreatic fistula or delayed gastric emptying. Postoperative complications classified as grade III in the Clavien–Dindo classification occurred in one patient (abdominal abscess). The pathology confirmed R0 resection in all patients who had pancreatic cancer (n = 5), IPMNs (n = 3), and high-grade pancreatic intraepithelial neoplasia (PanIN) (n = 1). The number of retrieved lymph nodes was 35 (11–49). The procedure with a left-posterior approach is a rational surgical technique in LDP for left-sided pancreatic cancer.
- Published
- 2020
23. Dlec1 is required for spermatogenesis and male fertility in mice
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Takahiro Yamagata, Hideo Dohra, Wataru Fujii, Keiichiro Yogo, Mamoru Nagano, Kiyotaka Toshimori, Yu Okitsu, and Chizuru Ito
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Male ,Reproductive biology ,lcsh:Medicine ,Biology ,Ion Channels ,Article ,Male infertility ,Mice ,Tubulin ,Intraflagellar transport ,medicine ,Animals ,Humans ,Spermatogenesis ,lcsh:Science ,Infertility, Male ,Multidisciplinary ,Tumor Suppressor Proteins ,Cilium ,HEK 293 cells ,lcsh:R ,medicine.disease ,Spermatozoa ,Phenotype ,Sperm ,Cell biology ,HEK293 Cells ,A549 Cells ,Organ Specificity ,Differentiation ,Adenocarcinoma ,lcsh:Q ,CRISPR-Cas Systems ,Gene Deletion - Abstract
Deleted in lung and esophageal cancer 1 (DLEC1) is a tumour suppressor gene that is downregulated in various cancers in humans; however, the physiological and molecular functions of DLEC1 are still unclear. This study investigated the critical role of Dlec1 in spermatogenesis and male fertility in mice. Dlec1 was significantly expressed in testes, with dominant expression in germ cells. We disrupted Dlec1 in mice and analysed its function in spermatogenesis and male fertility. Dlec1 deletion caused male infertility due to impaired spermatogenesis. Spermatogenesis progressed normally to step 8 spermatids in Dlec1−/− mice, but in elongating spermatids, we observed head deformation, a shortened tail, and abnormal manchette organization. These phenotypes were similar to those of various intraflagellar transport (IFT)-associated gene-deficient sperm. In addition, DLEC1 interacted with tailless complex polypeptide 1 ring complex (TRiC) and Bardet–Biedl Syndrome (BBS) protein complex subunits, as well as α- and β-tubulin. DLEC1 expression also enhanced primary cilia formation and cilia length in A549 lung adenocarcinoma cells. These findings suggest that DLEC1 is a possible regulator of IFT and plays an essential role in sperm head and tail formation in mice.
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- 2020
24. Enhancement of CO2 Adsorption/Desorption Properties of Solid Sorbents Using Tetraethylenepentamine/Diethanolamine Blends
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Katsunori Yogo, Hidetaka Yamada, and Duc Sy Dao
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Carbamate ,Diethanolamine ,Chemistry ,General Chemical Engineering ,medicine.medical_treatment ,General Chemistry ,Article ,chemistry.chemical_compound ,Adsorption ,Physisorption ,Elemental analysis ,Desorption ,medicine ,Amine gas treating ,Fourier transform infrared spectroscopy ,QD1-999 ,Nuclear chemistry - Abstract
Mesocellular silica foam was impregnated with tetraethylenepentamine (TEPA), diethanolamine (DEA), and their mixtures and examined as sorbents for CO2 capture. The sorbents were characterized by N2 physisorption, elemental analysis, and Fourier transform infrared spectroscopy. The effects of amine blending on the CO2 uptake, working capacity, and heat of adsorption were investigated and discussed. The experimental results showed that the heat of adsorption decreased with increasing DEA-to-TEPA ratios, but the CO2 uptake improved by the blending of TEPA and DEA. Furthermore, the DEA/TEPA blend considerably improved the regeneration properties of the sorbents. Mesocellular silica foam loaded with a mixture of 40 wt % TEPA and 30 wt % DEA exhibited a CO2 adsorption uptake of 5.91 mmol/g at 50 °C and 100 kPa with a heat of adsorption of 80 kJ/mol. Additionally, these sorbents demonstrated high cyclic stability and high selectivity toward CO2/N2 separation. In situ infrared spectroscopy investigations revealed that CO2 adsorption occurred predominantly through the formation of carbamate species for both TEPA and DEA.
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- 2020
25. Laparoscopic surgery for sigmoid colon cancer with complicated communication between the superior and inferior mesenteric arteries
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Satoru Kawai, Atsushi Ogura, Satoaki Kamiya, Kiyotaka Kawai, Ryutaro Kobayashi, Masanori Sando, Kenji Takagi, Takashi Maeda, Natsuki Nagano, and Konosuke Yogo
- Subjects
Left colic artery ,medicine.medical_specialty ,business.industry ,General Medicine ,medicine.disease ,Inferior mesenteric artery ,Surgery ,Vascular anomaly ,03 medical and health sciences ,Stenosis ,Middle colic artery ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,medicine.artery ,medicine ,030211 gastroenterology & hepatology ,Superior mesenteric artery ,business ,Median arcuate ligament syndrome ,Mesenteric arteries - Abstract
To perform complete mesocolic excision with central vessel ligation, it is important to recognize the vessel anomaly and the location of the tumor. For left-sided colon cancer, the variations in the course of the left colic artery and accessary middle colic artery must be recognized preoperatively. Here, we describe our experience with a 57-year-old man who was diagnosed with sigmoid colon cancer with complicated inter-mesenteric connections between the inferior mesenteric artery (IMA) and superior mesenteric artery (SMA), possibly due to median arcuate ligament syndrome. We performed laparoscopic sigmoidectomy with low ligation of the IMA to preserve the extremely enlarged left colic artery. The total operative time was 155 minutes, and the estimated total blood loss was 10 mL. The patient was discharged on postoperative day 9 without any postoperative complications. For patients with vascular anomalies in the left-sided mesocolon, preoperatively ruling out SMA stenosis by using angiography and 3-D CT might be important.
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- 2020
26. Short hydration with 20 mEq of magnesium supplementation for lung cancer patients receiving cisplatin-based chemotherapy: a prospective study
- Author
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Takahiro Hatta, Kiyofumi Yamada, Masashi Kondo, Kazuya Ichikawa, Yoshinori Hasegawa, Naoyuki Yogo, Naoya Ozawa, Mitsuo Sato, Masayuki Miyazaki, Tetsunari Hase, and Masahiko Ando
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Lung Neoplasms ,medicine.medical_treatment ,Renal function ,Antineoplastic Agents ,Kidney Function Tests ,Protective Agents ,Gastroenterology ,Nephrotoxicity ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Magnesium ,Prospective Studies ,Renal Insufficiency ,Lung cancer ,Aged ,Cisplatin ,Chemotherapy ,Creatinine ,business.industry ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,Palonosetron ,Regimen ,030104 developmental biology ,Oncology ,chemistry ,030220 oncology & carcinogenesis ,Dietary Supplements ,Antiemetics ,Female ,Kidney Diseases ,Surgery ,business ,Chemoradiotherapy ,medicine.drug - Abstract
Intravenous administration of magnesium with a short hydration regimen is recommended for patients receiving high-dose cisplatin to protect against cisplatin-induced nephrotoxicity. However, the optimal dose of magnesium supplementation has not been clarified. The aim of this trial was to investigate the safety and efficacy of a short hydration regimen with 20 mEq of magnesium supplementation for lung cancer patients receiving cisplatin-based chemotherapy. The key eligibility criteria included cytologically or histologically diagnosed lung cancer, candidacy for cisplatin-based (≥ 60 mg/m2) chemotherapy or chemoradiotherapy, no prior chemotherapy, aged 20–75 years, and adequate renal function. Cisplatin was administered with pre-hydration with 20 mEq of magnesium sulfate. Mannitol was administered just before cisplatin infusion to enforce diuresis. The primary endpoint was the proportion of patients who underwent cisplatin-based chemotherapy with a short hydration regimen with 20 mEq of magnesium supplementation without a grade 2 or higher elevation in creatinine. Forty patients with a median age of 66 years (range 35–74) were prospectively enrolled. Median baseline creatinine was 0.71 mg/dL. Median dose of cisplatin in the first cycle was 80 mg/m2. In the first cycle, no patients developed grade 2 creatinine toxicity. During the treatment period, one patient developed grade 2 creatinine elevation; thus, the proportion of patients without a grade 2 or higher elevation in creatinine was 97.5% (95% confidence interval 86.8–99.9). A short hydration regimen with 20 mEq of magnesium supplementation is safe and feasible for patients with lung cancer receiving cisplatin-based chemotherapy.
- Published
- 2020
27. The associations among emotional factors, personality traits, and addiction‐like eating: A study on university students in six Asian countries/regions
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Masao Yogo, Jung‐hyde Kwon, Jenny Ko, Elsie Yan, Catherine So-kum Tang, Anise Wu, and Yiqun Gan
- Subjects
Male ,Agreeableness ,Asia ,Universities ,Food addiction ,media_common.quotation_subject ,Emotions ,Impulsivity ,Young Adult ,Risk Factors ,medicine ,Humans ,Personality ,Big Five personality traits ,Students ,media_common ,Yale Food Addiction Scale ,Extraversion and introversion ,Psychiatry and Mental health ,Anxiety ,Female ,Food Addiction ,medicine.symptom ,Psychology ,Clinical psychology - Abstract
Objective Addiction-like eating (AE) is characterized by food cravings and loss of control over excessive food consumption. This study investigated the associations among emotional factors, personality traits, and AE symptoms in Asian young adults. Method This study included 6,823 Asian university students in South Korea, China, Singapore, Hong Kong/Macao, Japan, and Taiwan. Participants completed the modified Yale Food Addiction Scale (mYFAS) and scales on the Big-Five personality traits, impulsivity, anxiety, and depression. Results 6.2% of the participants met the mYFAS (DSM-IV-TR) food addiction diagnostic threshold. Participants from South Korea (7.9%) had the highest rate of food addiction, while participants from Japan (5.1%) and Taiwan (4.1%) reported the lowest rates. Emotional factors of anxiety and depression were the most robust correlates of AE symptoms, followed by country/region and personality factors of higher impulsivity, higher extraversion, and lower agreeableness. Personality correlates were region-specific. Higher impulsivity was a significant correlate for participants from South Korea and Taiwan, higher extraversion for participants from Singapore and Japan, and lower agreeableness for participants from China and Taiwan. Gender was also a significant correlate for participants from South Korea, Hong Kong/Macao, and Taiwan. Discussion Emotional and personality factors are important correlates of AE symptoms among Asian young adults.
- Published
- 2020
28. Usefulness of 18 F‐FDG‐PET/CT in the diagnosis and prediction of recurrence of pancreatic neuroendocrine neoplasms
- Author
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Yuji Nakamoto, Asahi Sato, Takayuki Anazawa, Yuichiro Uchida, Akitada Yogo, Kazuyuki Nagai, Kyoichi Takaori, Shinji Uemoto, Kenzo Nakano, and Toshihiko Masui
- Subjects
Oncology ,medicine.medical_specialty ,Univariate analysis ,Multivariate analysis ,Hepatology ,business.industry ,Disease ,Neuroendocrine tumors ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,030211 gastroenterology & hepatology ,Surgery ,Avidity ,Fdg pet ct ,Pancreas ,business ,Pathological - Abstract
Background Although 18 F-FDG-PET/CT is a widely used diagnostic tool for several malignancies, its efficacy in diagnosing pancreatic neuroendocrine tumors is reported to be controversial because of the short-term follow-up. Methods We retrospectively compared demographics and pathological features between 18 F-FDG-positive and -negative diseases. Additionally, we evaluated whether the avidity of 18 F-FDG-PET/CT affected earlier recurrence after curative treatment of non-functioning tumors. The median duration of observation was 65.6 months. Results Seventy-two patients were enrolled. 18 F-FDG-positive diseases were pathologically advanced and significantly associated with metastatic behavior. In a multivariate analysis, metastatic behavior and WHO tumor grade was independently associated with 18 F-FDG accumulation. Only 25% of functional tumors (4/16) and 8% of insulinomas (1/12) were 18 F-FDG-positive. In a Kaplan-Meier analysis in patients with non-functioning tumors (n = 56), 18 F-FDG-positivity was significantly correlated with poorer recurrence-free survival (RFS) but had no correlation with overall survival. In univariate analysis of factors associated with shorter RFS, male gender, prevalence of nodal metastasis, WHO tumor grade ≥G2, or 18 F-FDG-positive disease were significantly higher in patients with shorter RFS, whereas only 18 F-FDG-positivity was associated with shorter RFS in multivariate analyses. Conclusions The avidity of 18 F-FDG-PET/CT was associated with metastatic behavior of pancreatic neuroendocrine tumors and recurrence after treatment of non-functioning tumors.
- Published
- 2020
29. Tyrosinase Inhibition, Antiglycation, and Antioxidant Activity of Xylocarpus granatum
- Author
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Irmanida Batubara, Wulan Tri Wahyuni, Waras Nurcholis, Erna Subroto, Yogo Suro Priyadi, Kilala Tilaar, Saat Egra, Maily Mustofa, Fransiska Devy Junardy, and Nevianti Zamany
- Subjects
Antioxidant ,DPPH ,medicine.medical_treatment ,Tyrosinase ,Fractionation ,antiglycation, antioxidant, tyrosinase inhibition, xylocarpus granatum ,030226 pharmacology & pharmacy ,lcsh:Education (General) ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Xylocarpus granatum ,medicine ,Potency ,Bovine serum albumin ,lcsh:QH301-705.5 ,General Environmental Science ,biology ,Traditional medicine ,Chemistry ,General Engineering ,Fructose ,biology.organism_classification ,lcsh:Biology (General) ,030220 oncology & carcinogenesis ,biology.protein ,General Earth and Planetary Sciences ,lcsh:L7-991 - Abstract
Xylocarpus granatum is mangrove plant that traditionally used as face powder in Central Sulawesi, Indonesia which related to antioxidant, antiglycation and tyrosinase inhibition activities. This study aimed to evaluate the potency of X. granatum as a tyrosinase inhibitor, antiglycation, and antioxidant. The leaves, stem, stem bark, fruit flesh, fruit peel, and kernel of X. granatum were extracted using ethanol then their tyrosinase inhibition, antiglycation, and antioxidant were evaluated. Tyrosinase inhibition activity was evaluated using in vitro assay with L-tyrosine and L-DOPA as the substrate of monophenolase and diphenolase. Antiglycation activity was studied by measuring the excitation and emission fluorescence from glucose and fructose reaction with Bovine Serum Albumin. Antioxidant activity was measured using the DPPH radical scavenging assay. The result showed that the ethanolic extract of fruit flesh has higher potency as tyrosinase inhibitor (IC 50 of 393.8 mg/L and IC 50 of 448 mg/L, respectively for monophenolase and diphenolase). Antiglycation assay showed that the ethanolic extract of stem bark provides the strongest antiglycation activity with an IC 50 of 118.1 mg/L. Meanwhile, fruit peel provides the strongest antioxidant activity with an IC 50 of 5.5 mg/L. Fractionation of ethanolic extracts of each part of X. granatum tree yield fractions with lower bioactivity compared to the crude extract. Moreover, stem extract and fractions from two different locations (Tarakan and Kendari) tend to have different bioactivities strengths. The stem part of X granatum could be developed as new raw material of cosmetic product in Indonesia, while ethanol as the solvent for extraction, and the different bioactivity of stem extract from different location can be the consideration for the industry to standardize the extract prior to production of final product.
- Published
- 2020
30. A Case of Indeterminate Cell Histiocytosis
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Taketoshi Ide, Masutaka Furue, Maiko Yoshida, Noriko Kitagawa, Takeshi Nakahara, Shoko Yogo, Maiko Wada-Ohno, Makiko Kido-Nakahara, Gaku Tsuji, and Seisho Sato
- Subjects
Pathology ,medicine.medical_specialty ,P16 ink4a ,business.industry ,medicine ,Dermatology ,Indeterminate Cell Histiocytosis ,medicine.disease ,business - Published
- 2020
31. A case of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) without relapse after early steroid treatment
- Author
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Shinji Miyagawa, Yuki Asahara, Makiko Yogo, and Masahiko Suzuki
- Subjects
Adult ,Inflammation ,Male ,Pathology ,medicine.medical_specialty ,Chronic lymphocytic inflammation ,business.industry ,Methylprednisolone ,Diffusion Magnetic Resonance Imaging ,Treatment Outcome ,Steroid therapy ,Pulse Therapy, Drug ,Chronic Disease ,Encephalitis ,Humans ,Medicine ,Neurology (clinical) ,Infusions, Intravenous ,business ,Lymphatic Diseases ,Brain Stem ,Follow-Up Studies - Abstract
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a brainstem predominant lymphocytic inflammatory disease, which often relapses without oral immunosuppressants. This report describes a 37-year-old male case of CLIPPERS without relapse for 1 year after early steroid treatment. He was admitted to our hospital because of sensory disturbance in the left side of his body and ataxic gait. Gadolinium-enhanced T
- Published
- 2020
32. Long-term outcome and progression of osteoarthritis in uncomplicated cases of cranial cruciate ligament rupture treated by tibial plateau leveling osteotomy in dogs
- Author
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Nichika Mizokami, Yasushi Hara, Shuji Suzuki, Masakazu Shimada, Takuya Yogo, Yasuji Harada, Tom Ichinohe, and Nobuo Kanno
- Subjects
medicine.medical_specialty ,orthopedic surgery ,040301 veterinary sciences ,Stifle joint ,Osteoarthritis ,0403 veterinary science ,Cruciate ligament ,03 medical and health sciences ,Dogs ,Animals ,Medicine ,Dog Diseases ,Anterior Cruciate Ligament ,030304 developmental biology ,0303 health sciences ,Full Paper ,Tibia ,General Veterinary ,business.industry ,Anterior Cruciate Ligament Injuries ,tibial plateau leveling osteotomy ,04 agricultural and veterinary sciences ,medicine.disease ,Stifle ,Osteotomy ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,cranial cruciate ligament rupture ,Tibial-plateau-leveling osteotomy ,dog ,Orthopedic surgery ,stifle joint ,Disease Progression ,Ligament ,Tears ,business ,Medial meniscus - Abstract
The object of this study is to evaluate the long-term outcome of hind limb weight-bearing function and progression of stifle osteoarthritis (OA) after tibial plateau leveling osteotomy (TPLO). Groups were classified by the degree of cranial cruciate ligament (CrCL) damage and presence or absence of medial meniscus damage as macroscopically evaluated during surgery. Weight-bearing function was assessed via the peak vertical force (PVF), and OA progression was assessed via the radiographic OA score (OAS) preoperatively and 1, 3, 6, 12, 18, 24, and 36 months postoperatively. In all stifles, PVF was significantly higher within 6 months postoperatively than preoperatively, and this high ratio was maintained for 36 months. The OAS was significantly higher 24 months postoperatively than preoperatively in stifles with a partial CrCL tear, and significantly increased at each timepoint after 3 months postoperatively in stifles with complete CrCL rupture. The OAS remained consistently lower in stifles with a partial CrCL tear and no treatment of the medial meniscus than in stifles with complete rupture. Thus, after TPLO, the weight-bearing function improved in the early postoperative period and was maintained for as long as 36 months. Although OA progressed over time after TPLO, the progression was more gradual in stifles with partial tears than in those with complete rupture. Canine patients would benefit from earlier surgical intervention through development of technology that enables early detection of ligament degeneration.
- Published
- 2020
33. Successful Management of Airway and Esophageal Foreign Body Obstruction in a Child
- Author
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Chiaki Toida, Naoki Yogo, Masayasu Gakumazawa, Takashi Muguruma, Mafumi Shinohara, and Ichiro Takeuchi
- Subjects
Asphyxia ,medicine.medical_specialty ,business.industry ,Mortality rate ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,Esophageal foreign body ,Case Report ,lcsh:RC86-88.9 ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,High morbidity ,0302 clinical medicine ,medicine.anatomical_structure ,Swallowing ,030225 pediatrics ,medicine ,Esophagus ,Foreign body ,medicine.symptom ,Intensive care medicine ,business ,Airway - Abstract
Foreign body asphyxia is a serious clinical problem with high morbidity and mortality rates. It is relatively common among children, especially those younger than 3 years, because they have a high risk of aspirating foreign bodies owing to their tendency to place objects in their mouth and lack of a well-developed swallowing reflex. Moreover, the neurologic outcome after out-of-hospital cardiac arrests (OHCA) in pediatric patients remains generally poor. Here, we report an unusual pediatric case of asphyxial OHCA caused by foreign bodies obstructing the airway, complicating esophageal foreign body, with a neurologically favorable outcome. This case highlights the importance of adequate treatment for pediatric patients with OHCA, as well as the prompt and efficient management for pediatric patients with foreign bodies obstructing the airway and esophagus.
- Published
- 2019
34. Immune-related Liver Injury is a Poor Prognostic Factor in Patients with Nonsmall Cell Lung Cancer Treated with Immune Checkpoint Inhibitors
- Author
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Takafumi Yamamoto, Tetsunari Hase, Hiroki Kawashima, Masatoshi Ishigami, Takanori Ito, Naoyuki Yogo, Naozumi Hashimoto, Takashi Abe, Kenta Yamamoto, Takashi Honda, Takahiro Hatta, Norihiro Imai, Satoshi Yasuda, Hidenori Toyoda, Hirofumi Shibata, Mitsuhiro Fujishiro, Kazuyuki Mizuno, and Yoji Ishizu
- Subjects
Oncology ,Male ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,Immune checkpoint inhibitors ,Cell ,Drug Administration Schedule ,Immune system ,Internal medicine ,Carcinoma, Non-Small-Cell Lung ,medicine ,Carcinoma ,Humans ,Adverse effect ,Lung cancer ,Immune Checkpoint Inhibitors ,Aged ,Retrospective Studies ,Liver injury ,Lung ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Survival Analysis ,medicine.anatomical_structure ,Treatment Outcome ,Female ,Chemical and Drug Induced Liver Injury ,business - Abstract
It remains unclear whether severe liver immune-related adverse events (liver-irAEs) can affect the prognosis in non-small cell lung carcinoma (NSCLC) patients. Of the 365 NSCLC patients treated with immune checkpoint inhibitors (ICIs), 19 suffered from severe liver-irAEs (grade ≥3). The median time-to-onset of liver-irAEs was 53 days post-injection of the first ICI. The progression-free survival and overall survival of the liver-irAEs group (median 69 and 262 days, respectively) were significantly worse than the non-liver-irAEs group (128 and 722 days; P = 0.010 and P = 0.007; respectively). In conclusion, liver-irAEs were associated with poor prognosis in NSCLC patients.
- Published
- 2021
35. Author Correction: Proof-of-principle experiment for laser-driven cold neutron source
- Author
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D. Golovin, M. Nagata, Takuya Ishimoto, T. Mori, Akifumi Iwamoto, Yasuhiro Abe, Yuki Honoki, Akifumi Yogo, R. Kodama, S. R. Mirfayzi, Zechen Lan, D. Neely, Shinsuke Fujioka, S. Shokita, Hiroaki Nishimura, Kiyoko Okamoto, K. Mima, Satyabrata Kar, Yasunobu Arikawa, and M. Nakai
- Subjects
Physics ,Multidisciplinary ,business.industry ,Science ,Published Erratum ,Laser ,law.invention ,Optics ,law ,Proof of concept ,Medicine ,Neutron source ,business ,Author Correction ,General - Abstract
The scientific and technical advances continue to support novel discoveries by allowing scientists to acquire new insights into the structure and properties of matter using new tools and sources. Notably, neutrons are among the most valuable sources in providing such a capability. At the Institute of Laser Engineering, Osaka, the first steps are taken towards the development of a table-top laser-driven neutron source, capable of producing a wide range of energies with high brightness and temporal resolution. By employing a pure hydrogen moderator, maintained at cryogenic temperature, a cold neutron ([Formula: see text]) flux of [Formula: see text]/pulse was measured at the proximity of the moderator exit surface. The beam duration of hundreds of ns to tens of [Formula: see text] is evaluated for neutron energies ranging from 100s keV down to meV via Monte-Carlo techniques. Presently, with the upcoming J-EPoCH high repetition rate laser at Osaka University, a cold neutron flux in orders of [Formula: see text] is expected to be delivered at the moderator in a compact beamline.
- Published
- 2021
36. A Case of Folliculosebaceous Cystic Hamartoma Adjacent to a Trichilemmal Cyst
- Author
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Takeshi Nakahara, Shoko Yogo, Keiko Sakamoto, Hiromaro Kiryu, Masutaka Furue, and Makiko Kido-Nakahara
- Subjects
Pathology ,medicine.medical_specialty ,Trichilemmal cyst ,business.industry ,Medicine ,Folliculosebaceous cystic hamartoma ,Dermatology ,business ,medicine.disease - Published
- 2020
37. Community‐wide seasonal shifts in thermal tolerances of mosquitoes
- Author
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Daniel A. Hahn, Brunno F. Oliveira, Wendtwoin I. G. Yogo, Jiang Yongxing, and Brett R. Scheffers
- Subjects
0106 biological sciences ,Ecophysiology ,Ecology ,Acclimatization ,Climate Change ,010604 marine biology & hydrobiology ,Temperature ,Climate change ,Tropics ,Seasonality ,Atmospheric sciences ,medicine.disease ,010603 evolutionary biology ,01 natural sciences ,Latitude ,Culicidae ,Thermal ,Temperate climate ,medicine ,Animals ,Environmental science ,Seasons ,Ecology, Evolution, Behavior and Systematics ,Body Temperature Regulation - Abstract
The broadening in species' thermal tolerance limits and breadth from tropical to temperate latitudes is proposed to reflect spatial gradients in temperature seasonality, but the importance of seasonal shifts in thermal tolerances within and across locations is much less appreciated. We performed thermal assays to examine the maximum and minimum critical temperatures (CTmax and CTmin , respectively) of a mosquito community across their active seasons. Mosquito CTmin tracked seasonal shifts in temperature, whereas CTmax tracked a countergradient pattern with lowest heat tolerances in summer. Mosquito thermal breadth decreased from spring to summer and then increased from summer to autumn. We show a temporal dichotomy in thermal tolerances with thermal breadths of temperate organisms in summer reflecting those of the tropics ("tropicalization") that is sandwiched between a spring and autumn "temperatization." Therefore, our tolerance patterns at a single temperate latitude recapitulate classical patterns across latitude. These findings highlight the need to understand the temporal and spatial components of thermotolerance variation better, including plasticity and rapid seasonal selection, and the potential for this variation to affect species responses to climate change. With summers becoming longer and increasing winter nighttime temperatures, we expect increasing tropicalization of species thermal tolerances in both space and time.
- Published
- 2021
38. PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human Macrophages
- Author
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Mutsuko Hara, Takuya Yashiro, Sanae Araumi, Koichiro Uchida, Kyoko Yogo, Machiko Yamamoto, Chiharu Nishiyama, and Kazumi Kasakura
- Subjects
lcsh:Immunologic diseases. Allergy ,Small interfering RNA ,Inflammasomes ,THP-1 Cells ,Immunology ,macrophage ,IRF8 ,Mice ,Species Specificity ,Transcription (biology) ,inflammasome ,Proto-Oncogene Proteins ,Gene expression ,NLR Family, Pyrin Domain-Containing 3 Protein ,medicine ,Immunology and Allergy ,Animals ,Humans ,N LRP3 ,Promoter Regions, Genetic ,Transcription factor ,Original Research ,Gene knockdown ,integumentary system ,Chemistry ,Macrophages ,PU.1 ,Inflammasome ,U937 Cells ,Cell biology ,Gene Expression Regulation ,Gene Knockdown Techniques ,Interferon Regulatory Factors ,Trans-Activators ,lcsh:RC581-607 ,Chromatin immunoprecipitation ,medicine.drug - Abstract
NLRP3 inflammasomes play crucial roles in the initiation of host defense by converting pro-Caspase-1 to mature Caspase-1, which in turn processes immature IL-1β and IL-18 into their biologically active forms. Although NLRP3 expression is restricted to monocytic lineages such as monocytes, macrophages, and dendritic cells, the mechanisms determining the lineage-specific expression of NLRP3 remain largely unknown. In this study, we investigated the transcription factors involved in cell-type-specific transcription of NLRP3. We found that a distal, rather than a proximal, promoter of human NLRP3 was predominantly used in the human monocytic cell lines and macrophages. Reporter analysis showed that an Ets/IRF composite element (EICE) at -309/-300 and an Ets motif at +5/+8 were critical for transcriptional activity of the distal promoter. Electrophoretic mobility shift assays and chromatin immunoprecipitation assays demonstrated that two transcription factors, PU.1 and IRF8, both of which play essential roles in development and gene expression of the monocytic lineage, were bound to the EICE site, whereas PU.1 alone was bound to the Ets site. Knockdown of PU.1 and/or IRF8 mediated by small interfering RNA downregulated expression of NLRP3 and related molecules and markedly diminished the LPS-induced release of IL-1β in THP-1, suggesting that activity of the NLRP3 inflammasome was suppressed by knockdown of PU.1 and IRF8. Taken together, these results indicate that PU.1 and IRF8 are involved in the monocytic lineage-specific expression of NLRP3 by binding to regulatory elements within its promoter and that PU.1 and IRF8 are potential targets for regulating the activity of the NLRP3 inflammasome.
- Published
- 2021
39. Laparoscopic sacrocolpopexy in a patient with vault prolapse of the sigmoid stump after vaginoplasty in Mayer-Rokitansky-Küster-Hauser syndrome: A case report
- Author
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Yogo Sawada, Tokumasa Hayashi, Auran Rosanne Cortes, Manisha Yadav, Ratih Krisna, Masayoshi Nomura, Pattiya Nutthachote, and Shino Tokiwa
- Subjects
medicine.medical_specialty ,MRKH Syndrome ,RD1-811 ,Sigmoid stump prolapse ,MRKH syndrome, Mayer-Rokitansky-Küster-Hauser syndrome ,digestive system ,Article ,03 medical and health sciences ,0302 clinical medicine ,Mayer-Rokitansky-Küster-Hauser syndrome ,Neovagina ,medicine ,Mayer-Rokitansky-Kuster-Hauser Syndrome ,Laparoscopic sacrocolpopexy ,030212 general & internal medicine ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics and Gynecology ,Sigmoid function ,Gynecology and obstetrics ,medicine.disease ,digestive system diseases ,Surgery ,Müllerian agenesis ,LSC, laparoscopic sacrocolpopexy ,NTR, native tissue repair ,medicine.anatomical_structure ,Vagina ,RG1-991 ,Vaginoplasty ,Complication ,business - Abstract
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare congenital anomaly that results in Müllerian agenesis that affects the uterus and upper two-thirds of the vagina. Sigmoid vaginoplasty is a surgical treatment option; however, vaginal prolapse may result as a complication of the sigmoid neovagina. There are no standards for treatment due to the rarity of this condition. We present the case of a 59-year-old woman with a history of sigmoid vaginoplasty who underwent laparoscopic sacrocolpopexy (LSC) for grade IV sigmoid stump prolapse. The patient had a successful outcome and no evidence of recurrent prolapse. This clinical case reveals the feasibility of LSC as a surgical treatment for sigmoid stump prolapses in patients with MRKH syndrome., Highlights • There is no gold standard treatment for neovaginal prolapse, due to its rarity. • Laparoscopic sacrocolpopexy (LSC) can be considered as an optimal treatment of choice for neovaginal prolapse. • LSC for sigmoid stump prolapse in a patient with MRKH syndrome results to a good functional and anatomical outcome at 3-year follow up.
- Published
- 2021
40. A Large Scale Outbreak of Food Poisoning Caused by Broiled Eels Contaminated with Salmonella Serovar Saintpaul
- Author
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Kazuhiko Uchida, Shinji Tachino, Manabu Aono, Kotoha Kimura, Chizuko Kimura, Nozomi Yogo, Hiroto Shinomiya, Yukiko Asano, Naoaki Tomita, Masayuki Fukuda, Yuki Abe, Yukihiro Kitagawa, Tatsuya Karasudani, Keiko Semba, Seiji Takekata, and Risa Kikuchi
- Subjects
Serotype ,Salmonella ,Veterinary medicine ,Food poisoning ,Scale (ratio) ,medicine ,Environmental science ,Outbreak ,Contamination ,medicine.disease ,medicine.disease_cause - Published
- 2019
41. Hepatocellular carcinoma with duodenal invasion resected subsequent to multimodal therapies: A case report
- Author
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Tetsuro Hirose, Tomoko Okuno, Ryuichiro Doi, Takashi Ito, Atsushi Matsumoto, and Akitada Yogo
- Subjects
Sorafenib ,medicine.medical_specialty ,Hepatocellular carcinoma ,medicine.medical_treatment ,Duodenal invasion ,TACE, transarterial chemoembolization ,Pancreas-preserving partial duodenectomy ,Gastroenterology ,Article ,Disease course ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Case report ,medicine ,Hepatectomy ,Embolization ,Collateral vessels ,neoplasms ,DEB-TACE, drug-eluting beads-transarterial chemoembolization ,AFP, α-fetoprotein ,business.industry ,BCLC, Barcelona Clinic Liver Cancer ,medicine.disease ,GI, gastrointestinal ,digestive system diseases ,PIVKA-2, protein induced by vitamin K absence or antagonist -Ⅱ ,Major duodenal papilla ,medicine.anatomical_structure ,JSH, the Japan Society of Hepatology ,HPPD, hepatectomy with pancreas-preserving partial duodenectomy ,030220 oncology & carcinogenesis ,Duodenum ,030211 gastroenterology & hepatology ,Surgery ,HPD, hepatectomy with pancreaticoduodenectomy ,business ,HCC, hepatocellular carcinoma ,medicine.drug - Abstract
Highlights • Hepatocellular carcinoma (HCC) with duodenal invasion is a very rare occurrence. • Aggravated disease condition of HCC with duodenal invasion usually makes surgical treatment not advisable. • We present the first case of HCC with duodenal invasion resected following a multimodal therapy that included sorafenib. • Partial hepatectomy in conjunction with partial duodenectomy was selected to lessen surgical stress. • Surgical resection should be taken into consideration as a therapeutic choice even in progressive HCC disease condition., Introduction Gastrointestinal (GI) involvement in hepatocellular carcinoma (HCC) is uncommon. In particular, HCC with duodenal invasion is known to be a rare condition. In such cases, surgical indication has been generally negative except in few reported cases. To our knowledge, this report describes the first case of HCC with duodenal invasion, resected by hepatectomy accompanied by pancreas-preserving partial duodenectomy (HPPD) following multimodal therapies including systemic sorafenib administration. Case presentation A 65-year-old man had been repeatedly treated for multiple HCCs by transarterial chemoembolization (TACE) and sorafenib. However, the main tumor formerly ruptured began to involve his duodenum, causing GI bleeding. The collateral vessels from the pancreatic and omental branches entered the tumor and nullified the transarterial hemostatic embolization. Hence, HPPD was performed to preserve the major Vater papilla. Histopathological examination revealed poorly-to -moderately differentiated HCC cells invading the duodenum. Discussion and conclusion HPPD treatment successfully removed HCC with duodenal invasion achieving viable tumor clearance status (R0). We underline the importance of achieving viable tumor clearance status at any time during the treatment course of patients with advanced HCC as this approach may be the only approach to enable HCC patients with duodenal invasion to resume a healthy life.
- Published
- 2019
42. Successful Conservative Treatment of Traumatic Intraperitoneal Bladder Rupture in a Child: A Case Report
- Author
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Naoki Yogo, Makoto Kato, Ichiro Takeuchi, Mafumi Shinohara, Chiaki Toida, Ko Takahashi, Takashi Muguruma, and Masayasu Gakumazawa
- Subjects
Conservative treatment ,medicine.medical_specialty ,Bladder rupture ,business.industry ,Medicine ,General Medicine ,urologic and male genital diseases ,business ,Surgery - Abstract
The urinary bladder is protected by the pelvic bones and hence is a site less susceptible to external force injury than other organs. As children’s bones are not fully developed, the risk of bladder injury by external force is greater in children than adults. Pelvic fractures often cause the bladder to rupture, as do strong external forces when the bladder is filled. Bladder rupture is categorized as extraperitoneal or intraperitoneal, and treatments differ between the two. Extraperitoneal injury usually heals after drainage alone, whereas intraperitoneal injury usually requires surgical intervention such as a combination of surgical repairs and drainage. Herein, we report a pediatric case of intraperitoneal bladder rupture successfully treated without surgical repair (i.e., with drainage via an intraperitoneal tube and a urethral catheter only). Our report suggests that nonoperative treatment is an option for pediatric patients with intraperitoneal bladder rupture if certain conditions are met.
- Published
- 2019
43. Pancreatic acinar cell carcinoma diagnosed by BCL10 staining: A case report
- Author
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Kyouichi Takaori, Kei Yamane, Seiichiro Tada, Yuichiro Uchida, Kenta Inoguchi, Shinji Uemoto, Toshihiko Masui, Kenzo Nakano, Akitada Yogo, Takayuki Anazawa, and Kazuyuki Nagai
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,medicine ,business ,BCL10 ,Pancreatic Acinar Cell Carcinoma ,Staining - Published
- 2019
44. Clinical and experimental studies of intraperitoneal lipolysis and the development of clinically relevant pancreatic fistula after pancreatic surgery
- Author
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Asahi Sato, Kyoichi Takaori, Yasuhiko Tabata, Toshihiko Masui, Yuichiro Uchida, Kazuyuki Nagai, Takayuki Anazawa, Shinji Uemoto, Kenzo Nakano, and Akitada Yogo
- Subjects
Male ,medicine.medical_specialty ,Lipolysis ,Fistula ,Fatty Acids, Nonesterified ,Intra-Abdominal Fat ,Gastroenterology ,Pancreaticoduodenectomy ,Rats, Sprague-Dawley ,Pancreatic Fistula ,03 medical and health sciences ,chemistry.chemical_compound ,Pancreatectomy ,Postoperative Complications ,0302 clinical medicine ,Pancreatic Juice ,Risk Factors ,Internal medicine ,medicine ,Animals ,Humans ,Aged ,Triglyceride ,business.industry ,Lipase ,Middle Aged ,medicine.disease ,Disease Models, Animal ,Orlistat ,medicine.anatomical_structure ,chemistry ,Pancreatic fistula ,Obesity, Abdominal ,030220 oncology & carcinogenesis ,Lipase inhibitors ,Pancreatic juice ,Female ,030211 gastroenterology & hepatology ,Surgery ,Pancreas ,business ,medicine.drug - Abstract
Background Visceral obesity is one of the risk factors for clinically relevant pancreatic fistula after pancreatic resection. The objective of this study was to evaluate the impact of intraperitoneal lipolysis on postoperative pancreatic fistula. Methods The degree of intraperitoneal lipolysis was investigated by measuring the free fatty acid concentration in drain discharge in patients after pancreatic resection. An experimental pancreatic fistula model was prepared by pancreatic transection, and the impact of intraperitoneal lipolysis was evaluated by intraperitoneal administration of triolein (triglyceride) with, or without orlistat (lipase inhibitor). Results Thirty-three patients were included in the analysis. The free fatty acid concentration in drain discharge on postoperative day 1 was significantly associated with the development of a clinically relevant pancreatic fistula (P = 0·004). A higher free fatty acid concentration in drain discharge was associated with more visceral adipose tissue (P = 0·009). In the experimental model that included 98 rats, intraperitoneal lipolysis caused an increased amount of pancreatic juice leakage and multiple organ dysfunction. Intraperitoneal administration of a lipase inhibitor reduced lipolysis and prevented deterioration of the fistula. Conclusion Intraperitoneal lipolysis significantly exacerbates pancreatic fistula after pancreatic resection. Inhibition of lipolysis by intraperitoneal administration of a lipase inhibitor could be a promising therapy to reduce clinically relevant postoperative pancreatic fistula. Surgical relevance Clinically, there are two types of pancreatic fistula after pancreatic resections: harmless biochemical leak and harmful clinically relevant pancreatic fistula. Visceral obesity is one of the known risk factors for clinically relevant pancreatic fistula; however, the underlying mechanisms remained to be elucidated. Patients with clinically relevant pancreatic fistula had a higher free fatty acid concentration in the drain discharge, suggesting a relationship between intraperitoneal lipolysis and pancreatic fistula. The experimental model of pancreatic fistula demonstrated that intraperitoneal lipolysis caused deterioration in pancreatic fistula, suggesting that intraperitoneal lipolysis is one of the mechanisms that drives biochemical leakage to clinically relevant pancreatic fistula. Intraperitoneal administration of a lipase inhibitor prevented lipolysis as well as pancreatic fistula deterioration in the experimental model, suggesting a future clinical application for lipase inhibitors in prevention of clinically relevant pancreatic fistula.
- Published
- 2019
45. Gallbladder Metastases of Invasive Ductal Carcinoma of the Breast Resected 9 Years after Initial Mastectomy
- Author
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Takashi Ito, Hideaki Oe, Ryuichiro Doi, Tetsuro Hirose, Jun Matsubayashi, Tomoko Okuno, Akitada Yogo, Naoto Nakamura, and Yusuke Abe
- Subjects
medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Gallbladder ,medicine.medical_treatment ,Gastroenterology ,medicine ,Surgery ,Radiology ,Invasive ductal carcinoma ,business ,Mastectomy - Published
- 2018
46. Relative risks of Internet-related addictions and mood disturbances among college students: a 7-country/region comparison
- Author
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Anise M. S. Wu, J.H. Kwon, J.H.C. Ko, Elsie Yan, Catherine So-kum Tang, Yiqun Gan, Masao Yogo, and Yee Woen Koh
- Subjects
Adult ,Cross-Cultural Comparison ,Male ,Risk ,Asia ,Adolescent ,Universities ,media_common.quotation_subject ,education ,Anxiety ,Social Networking ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Intervention (counseling) ,mental disorders ,medicine ,Humans ,Students ,China ,Depression (differential diagnoses) ,media_common ,Internet ,Depression ,business.industry ,Addiction ,Public Health, Environmental and Occupational Health ,General Medicine ,United States ,030227 psychiatry ,Behavior, Addictive ,Cross-Sectional Studies ,Video Games ,Relative risk ,Female ,The Internet ,Health education ,medicine.symptom ,business ,Psychology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Objectives This study aimed to determine the relative risks of addiction to the Internet, online gaming and online social networking of college students in six Asian countries/regions (Singapore, Hong Kong [HK]/Macau, China, South Korea, Taiwan and Japan) compared with students in the United States (US). It also explored the relative risks of depression and anxiety symptoms among students with Internet-related addictions from these countries/regions. Study design This is a cross-sectional survey. Methods A convenience sample of 8067 college students aged between 18 and 30 years was recruited from seven countries/regions. Students completed a survey about their use of the Internet, online gaming and online social networking as well as the presence of depression and anxiety symptoms. Results For all students, the overall prevalence rates were 8.9% for Internet use addiction, 19.0% for online gaming addiction and 33.1% for online social networking addiction. Compared with the US students, Asian students showed higher risks of online social networking addiction but displayed lower risks of online gaming addiction (with the exception of students from HK/Macau). Chinese and Japanese students also showed higher risks of Internet addiction compared with the US students. In general, addicted Asian students were at higher risks of depression than the addicted US students, especially among Asian students who were addicted to online gaming. Addicted Asian students were at lower risks of anxiety than the addicted US students, especially among Asian students who were addicted to online social networking, and addicted students from HK/Macau and Japan were more likely to have higher relative risks of depression. Conclusions There are country/regional differences in the risks of Internet-related addictions and psychiatric symptoms. It is suggested that country/region-specific health education programmes regarding Internet-related addictions are warranted to maximise the efficiency of prevention and intervention. These programmes should attempt to tackle not only problematic Internet-related behaviours but also mood disturbances among college students.
- Published
- 2018
47. Preoperative risk stratification of lymph node metastasis for non-functional pancreatic neuroendocrine neoplasm: An international dual-institutional study
- Author
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Etsuro Hatano, Emily K. Bergsland, Grace E. Kim, Bryan K. Le, Eric K. Nakakura, Asahi Sato, Thomas A. Hope, Kazuyuki Nagai, Toshihiko Masui, Kyoichi Takaori, Yosuke Kasai, Takayuki Anazawa, Yuichiro Uchida, Kenzo Nakano, Akitada Yogo, Shinji Uemoto, and Julia Whitman
- Subjects
Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Lymph node metastasis ,Logistic regression ,Gastroenterology ,Risk Assessment ,California ,Japan ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,medicine ,Humans ,Neoplasm Invasiveness ,Aged ,Neoplasm Staging ,Retrospective Studies ,Pancreatic duct ,Hepatology ,business.industry ,Odds ratio ,Middle Aged ,Confidence interval ,Pancreatic Neuroendocrine Neoplasm ,Pancreatic Neoplasms ,medicine.anatomical_structure ,Lymphatic Metastasis ,Lymph Node Excision ,Lymphadenectomy ,Female ,Lymph ,Lymph Nodes ,business - Abstract
BACKGROUND /Objectives: Although the presence of lymph node metastasis (LNM) defines malignant potential, preoperative prediction of LNM has not been established for non-functional pancreatic neuroendocrine neoplasm (NF-PNEN). We sought to develop a prediction system using only preoperatively available factors that would stratify the risk of LNM for NF-PNEN. METHODS We retrospectively reviewed patients who underwent R0/1 resection of NF-PNEN at Kyoto University (2007-2019) and the University of California, San Francisco (2010-2019). Risk stratification of LNM was developed using preoperative factors by the logistic regression analysis. Long-term outcomes were compared across the risk groups. RESULTS A total of 131 patients were included in this study. Lymph nodes were pathologically examined in 116 patients, 23 (20%) of whom had LNM. Radiological tumor size [1.5-3.5 cm (odds ratio: 13.5, 95% confidence interval: 1.77-398) and >3.5 cm (72.4, 9.06-2257) against ≤1.5 cm]
- Published
- 2021
48. Methaemoglobinaemia due to food protein-induced enterocolitis syndrome
- Author
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Naoki Yogo and Shota Fujito
- Subjects
medicine.medical_specialty ,Sodium bicarbonate ,business.industry ,Bicarbonate ,medicine.disease ,Food protein-induced enterocolitis syndrome ,chemistry.chemical_compound ,Endocrinology ,Blood pressure ,chemistry ,Term Infant ,Shock (circulatory) ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Heart rate ,medicine ,medicine.symptom ,business ,Oxygen saturation (medicine) - Abstract
A 25-day-old term infant presented with fever, diarrhoea and 10% wt loss since birth (figure 1A) and 80% oxygen saturation in ambient air. His heart rate was 178 beats/min and blood pressure was 64/45 mmHg. Blood tests revealed a pH of 7.0, and bicarbonate, lactate and methaemoglobin levels of 6.2 mmol/L, 5.2 mmol/L, and 21%, respectively. After rehydration with fluid for shock, administration of sodium bicarbonate and stopping formula milk, …
- Published
- 2021
49. Red Blood Cell-Shaped Microparticles with a Red Blood Cell Membrane Demonstrate Prolonged Circulation Time in Blood
- Author
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Toshinobu Yogo, Eri Usugi, Koichiro Hayashi, Wataru Sakamoto, Masatoshi Watanabe, and Shota Yamada
- Subjects
0301 basic medicine ,congenital, hereditary, and neonatal diseases and abnormalities ,Biodistribution ,Chemistry ,Biomedical Engineering ,nutritional and metabolic diseases ,hemic and immune systems ,Spleen ,02 engineering and technology ,Pharmacology ,021001 nanoscience & nanotechnology ,Biomaterials ,03 medical and health sciences ,Red blood cell ,030104 developmental biology ,Membrane ,medicine.anatomical_structure ,Drug delivery ,medicine ,Surface structure ,Circulation time ,Microparticle ,skin and connective tissue diseases ,0210 nano-technology ,circulatory and respiratory physiology - Abstract
Prolonging the circulation time (CT) of microparticles (MPs) in the blood is key for a successful microparticle-based medicinal approach to serve as drug delivery systems (DDSs). Previously, we reported that MPs that mimic the shape of red blood cells (RBCs) avoid accumulation in the spleen and lungs. We now describe the effectiveness of mimicking not only the shape of RBCs but also their surface structure for the prolongation of CT. RBC-shaped MPs (RBC-MPs) were electrosprayed with cellulose and covered with a native RBC membrane (RBCM) collected from mouse blood. Seven hours after intravenous injection, approximately twice as many RBCM-covered RBC-MPs (RBC-MPs@RBCM) were present in the blood of mice compared to unmodified RBC-MPs. Twenty-four hours postinjection, the concentration of RBC-MPs@RBCM in the blood was 4 times higher. These findings suggest that an RBCM covering the MPs contributed to significant CT prolongation, which may positively impact their applications as DDSs.
- Published
- 2021
50. Point prevalence survey to evaluate the seropositivity for coronavirus disease 2019 (COVID-19) among high-risk healthcare workers
- Author
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Omid Bakhtar, Norihiro Yogo, Besa Smith, Kristina L. Greenwood, Stephen Munday, Leslie Thompson, Pamela J Wells, and Tyler C. Smith
- Subjects
Positive antibody ,Point prevalence survey ,Microbiology (medical) ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,SARS-CoV-2 ,business.industry ,Epidemiology ,Health Personnel ,viruses ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Concise Communication ,virus diseases ,COVID-19 ,medicine.disease_cause ,Virology ,Virus ,Infectious Diseases ,Surveys and Questionnaires ,Health care ,Prevalence ,Humans ,Medicine ,business ,Coronavirus - Abstract
Among 1,770 healthcare workers serving in high-risk care areas for coronavirus disease 2019 (COVID-19), 39 (2.2%) were seropositive. Exposure to severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in the community was associated with being seropositive. Job or unit type and percentage of time working with COVID-19 patients were not associated with positive antibody tests.
- Published
- 2020
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