1. Noninvasive evaluation of diabetic patients with high fasting blood glucose using DWI and BOLD MRI
- Author
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Yue-Ming He, Jie Lu, and Shuang-Shuang Zheng
- Subjects
Blood Glucose ,medicine.medical_specialty ,Urology ,Renal function ,Type 2 diabetes ,Kidney ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,medicine ,Humans ,Effective diffusion coefficient ,Radiology, Nuclear Medicine and imaging ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Type 2 Diabetes Mellitus ,Magnetic resonance imaging ,Fasting ,Hypoxia (medical) ,medicine.disease ,Magnetic Resonance Imaging ,Diffusion Magnetic Resonance Imaging ,medicine.anatomical_structure ,Diabetes Mellitus, Type 2 ,030220 oncology & carcinogenesis ,medicine.symptom ,business - Abstract
To investigate the renal microstructure changes and hypoxia changes in type 2 diabetic patients and the relationship between them and glucose using both diffusion-weighted imaging (DWI) and blood oxygenation level-dependent magnetic resonance imaging (BOLD MRI). After measuring morning fasting blood glucose, DWI and BOLD MRI were performed in 57 patients with type 2 diabetes mellitus (DM group) and 14 healthy volunteers (NC group). According to the fasting blood glucose levels, diabetic patients were divided into a normoglycemic diabetes group (group A), a less hyperglycemic diabetes group (group B) and a more hyperglycemic diabetes group (group C). The renal parenchymal apparent diffusion coefficient (ADC), renal cortical R2* (CR2*), and medullary R2* (MR2*) were measured, and the R2* ratio between the medulla and cortex (MCR) was calculated. To test for differences in ADC, R2*, and MCR among the four groups, the data were analyzed by separate one-way ANOVAs. The correlations between ADC, R2*, and MCR and the clinical index of renal function were analyzed. Groups B and C had significantly lower ADC values in the renal parenchyma (P = 0.048, 0.002) and significantly higher MR2* and MCR values (P
- Published
- 2020