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Objective: Patellofemoral Pain Syndrome (PFPS) is one of the most common disorders of the knee joint. It is characterized by pain, reduced proprioception, and altered pattern of vastus muscle activation, which effectively maintain the balance needed for performing daily living activities such as walking and running. One treatment method that can reduce pain and improve balance in people with PFPS is Kinesiology Taping (KT). Considering the physiological and anatomical differences in the knee structure of men and women and the importance of studying the effect of KT on the dynamic balance of men with PFPS, this study aims to compare the effect of KT on dynamic balance and pain of men and women with unilateral PFPS. Materials & Methods: This is a quasi-experimental and non-randomized clinical trial. The participants were 30 males and 31 females aged 18-40 years suffering from unilateral PFPS. They were recruited using a convenience sampling method. First, the subjects performed the Y-balance test three times in each of the anterior, posteromedial, and posterolateral directions. The maximum score obtained from the three repetitions in each direction was divided by the limb length and recorded in percentage as a dynamic balance score. After 5 minutes of rest and performing initial tests, the subjects performed the intervention. In this stage, KT with a tension equal to 50%-75% of its initial length was applied on the patella of the involved limb to cause medial glide. The effectiveness of KT was examined under a single-leg squat-test. For this purpose, all subjects performed unilateral squatting on their affected leg for 10 seconds with 45 degrees of knee flexion before and after KT, while their pain level was recorded using the visual analog scale. In case of a 50% reduction in pain, the subjects were allowed to enter the final stage (performing the Y-balance test); otherwise, patellar taping was repeated to obtain the appropriate pain reduction. Results: Within-group comparison of balance parameters before and after KT using the paired t-test showed an increase in the reach distance at three directions in the Y-balance test, revealing a significant improvement in the dynamic balance following KT (P0.05). Moreover, the pain was significantly reduced in both genders after KT (P0.05). Conclusion: KT is an appropriate therapeutic intervention for improving dynamic balance and reducing pain in people with PFPS. It seems that KT has the same effect on dynamic balance and pain of women and men with PFPS.

Background Scavenger receptor class B type 1 (SR-BI) encoded by SCARB1 gene serves as a multifunctional HDL receptor, facilitating the uptake of cholesteryl esters from HDL to the liver. Recent studies have identified the association between the P376L missense mutation of the SCARB1 gene with increased serum HDL-Cholesterol level. However, the contribution of this variant to the development of cardiovascular disease (CVD) remains unclear. Objective We have investigated the association between the P376L polymorphism with the properties of HDL and CVD outcomes in a population sample recruited as part of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort. Methods Six hundred and fifteen individuals who had a median follow-up period of 7 years were recruited as part of the MASHAD cohort. Anthropometric, biochemical parameters and HDL lipid peroxidation (HDLox) were assessed. Genotyping was performed using TaqMan-real-time-PCR based method. The association of P376L-rs74830766 with cardiovascular-risk-factors and CVD events were evaluated. Results Carriers of the P376L variant were significantly more likely than non-carriers to develop CVD using multivariate analyses adjusted for traditional CVD risk factors defined as: age, sex, BMI, presence of diabetes, or hypertension, positive smoking habit, and total cholesterol (OR: 3.75, 95%CI: 1.76–7.98, p = 0.001). In an adjusted model, there was a two fold increase in cardiovascular endpoints among individuals who were heterozygous for the P376L variant (hazard ratio, 2.08; 95% CI, 1.12-to 3.84, p = 0.02). Although there was no association between the presence of the P376L variant and HDL-C level, serum HDLox, measured as dysfunctional HDL, was 13% higher among carriers of the P376L variant than non-carriers. Conclusion We have found that carriers of the P376L variant possessed higher HDLox and were at increased risk of CVD in a representative population-based cohort, as compared to non-carriers.

Cervical cancer is among the most common type of cancers in women and is associated with human papillomavirus (HPV) infection. Genital warts are also reported to be linked with HPV infection types 11 and 6. In turn, clinical characteristics and morphological features of warts may be useful in the prediction of prognosis and in making treatment decisions. Thus, we have investigated the association of high and low-risk HPVs genotype with genital wart risk, as well as pathological and cytological information in cases recruited from a population-based cohort study of 1380 patients. Patients infected with HPV genotype 6 or 11 had an increased risk of having warts, with OR of 2.34 (95% CI: 0.955-5.737, P = 0.06). Also, this association was enhanced in the presence of high plus low-risk HPV for having genital wart (OR: 2.814; 95%: 1.208-6.55, P = 0.017) and cases having high-risk HPV (OR: 2.329; 95% CI: 1.029-5.269, P = 0.042). Moreover, we observed patients with genital warts having CIN2/3, indicating the importance of informing the physician to the patient to prevent more severe lesions. Our data demonstrated that patients with both low/high-risk HPV types had an increased risk of developing genital warts and persistent infection with HPV was a necessary precursor for the increase in cervical lesions.

Small noncoding microRNAs (miRNAs) are known as noninvasive biomarkers for early detection in various cancers. In fact, miRNAs have key roles in carcinogenicity process such as proliferation, apoptosis and metastasis. After cardiovascular disease, cancer is the second cause of death in the world with an estimated 9.6 million deaths in 2018. So, early diagnosis of cancer is critical for successful treatment. To date, several selective and sensitive laboratory-based methods have been applied for the detection of circulating miRNA, but a simple, short assay time and low-cost method such as a biosensor method as an alternative approach to monitor cancer biomarker is required. In this review, we have highlighted recent advances in biosensors for circulating miRNA detection.

Cervical cancer (CC) is a common malignancy in women and a major cause of cancer- related mortality globally. Some novel biomarkers may enable the early diagnosis and monitoring of CC. MicroRNAs are small noncoding RNAs that control gene translation at a post transcriptional level. Hence the deregulation of these molecules can cause many diseases. There appears to be an association between aberrant miRNA expression and CC, but the molecular mechanisms involved in the development of CC remain unknown. The upregulation of some circulating miRNAs, e.g. miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue specific-miRNAs, e.g. miR-7, miR-10a, miR-17-5p, miR-135b, miR-149 and miR-203 has been found in patients with CC. There is also growing evidence for the importance of miRNAs in the development of drug-resistance. This review therefore highlights recently published preclinical and clinical investigation performed on tissue-specific and circulating miRNAs, as potential biomarkers for the detection of patients at early stages of CC, in the prediction of prognosis, and monitoring of their response to therapy.\ud Key word: cervical cancer, CIN, MiRNA, circulating biomarker, tissue-specific biomarker, HPV