Search

Background: We examined the association between childhood poverty and mental health disorders (MHD) in childhood and early adulthood. We also investigated whether the association between poverty in childhood and MHD is mediated by exposure to stressful life events (SLE). Methods: We used data from a prospective community cohort of young people assessed at baseline (M=9.7 years, SD=1.9), first (M=13.5 years, SD=1.9), and second (M=18.2 years, SD=2.0) follow-ups (N=1,590) in Brazil. Poverty was assessed using a standardized classification. Exposure to 20 different SLE was measured using the Life History instrument. Psychiatric diagnoses were evaluated using the Development and Well-Being Assessment. Latent growth models investigated the association between poverty at baseline and the growth of any MHD, externalizing, and internalizing disorders. Mediation models evaluated whether the association between childhood poverty and MHD in early adulthood was mediated by exposure to SLE. Results: Poverty affected 11.4% of the sample at baseline and was associated with an increased propensity for presenting externalizing disorders in adolescence or early adulthood (standardized estimate=0.27, p=0.016). This association was not significant for any disorder or internalizing disorders. Childhood poverty increased the likelihood of externalizing disorders in early adulthood through higher exposure to SLE (OR=1.07, 95CI% 1.01–1.14). Results were only replicated among females in stratified analyses. Conclusions: Childhood poverty had detrimental consequences on externalizing MHD in adolescence, especially among females. Poverty and SLE are preventable risk factors that need to be tackled to reduce the burden of externalizing disorders in young people.

Twin studies suggest a substantial role for genes in explaining individual differences in aggressive behavior across development. It is unclear, however, how directly measured genetic risk is associated with aggressive behavior at different moments across adolescence and how genes might distinguish developmental trajectories of aggressive behavior. Here, a polygenic risk score derived from the EAGLE-Consortium genome-wide association study of aggressive behavior in children was tested as predictor of latent growth classes derived from those measures in an adolescent population (n = 2229, of which n = 1246 with genetic information) and a high-risk sample (n = 543, of which n = 335 with genetic information). In the population sample, the polygenic risk score explained variation in parent-reported aggressive behavior at all ages and distinguished between stable low aggressive behavior and moderate and high-decreasing trajectories based on parent-report. In contrast, the polygenic risk score was not associated with self- and teacher-reported aggressive behavior, and no associations were found in the high-risk sample. This pattern of results suggests that methodological choices made in genome-wide association studies impact the predictive strength of polygenic risk scores, not just with respect to power but likely also in terms of generalizability and specificity.

Investigating the concepts affecting individuals' attachment styles in early adulthood is essential for healthy and satisfying social and emotional/romantic relationships. The purpose of this study was to examine the direct effects of self-esteem, loneliness, and emotional dependency on university students’ attachment styles. In addition, this study investigated the mediating roles of emotional dependency and loneliness on the relationships between attachment styles and self-esteem. The research group consisted of 518 volunteer university students in their first adulthood. Demographic Information Form, Rosenberg Self- Esteem Scale (RSES), Experiences in Close Relationships- Revised (ECR- R), Emotional Dependency, and UCLA Loneliness Scale were used to collect the data. Pearson moments correlation coefficients, hierarchical regression analyses, and bootstrapping methods were performed to test the hypotheses. The results of hierarchical regression analysis showed that self-esteem negatively and loneliness positively predicted anxious and avoidant attachment styles. Emotional dependency positively predicted anxious attachment and negatively predicted avoidant attachment styles. In addition, the bootstrapping analysis showed that loneliness played a significant partial mediator role on the relationships between self-esteem and avoidant and anxious attachment, while emotional dependency was not a significant mediator. The findings were discussed along with the theoretical basis and the previous findings, and suggestions were presented for future studies., İlk yetişkinlik dönemindeki bireylerin bağlanma stillerini etkileyen kavramların araştırılması kişilerin sağlıklı ve doyum verici sosyal ve duygusal/romantik ilişkileri için önem arz etmektedir. Bu araştırmanın amacı ilk yetişkinlik dönemindeki üniversite öğrencilerinin bağlanma stilleri üzerinde benlik saygısı, yalnızlık ve duygusal bağımlılığın doğrudan etkilerinin incelenmesidir. Ayrıca bu araştırmada duygusal bağımlılığın ve yalnızlığın bağlanma stilleri ile benlik saygısı arasındaki ilişkilerdeki aracı rolü de incelenmiştir. Araştırma grubunu gönüllü 518 ilk yetişkinlik dönemindeki üniversite öğrencileri oluşturmaktadır. Araştırmada veriler Demografik Bilgi Formu, Rosenberg Benlik Saygısı Ölçeği, Yakın İlişkilerde Yaşantılar Envanteri II, Duygusal Bağımlılık Ölçeği ve UCLA Yalnızlık Ölçeği aracılığı ile toplanmıştır. Araştırmadaki hipotezleri test etmek amacıyla Pearson momentler çarpım korelasyon katsayısı, hiyerarşik regresyon analizi ve yeniden örnekleme yöntemi (bootstrapping) yapılmıştır. Hiyerarşik regresyon analizi sonuçlarına göre benlik saygısı kaygılı ve kaçınan bağlanmayı negatif yönde, yalnızlık ise pozitif yönde yordamıştır. Duygusal bağımlılık ise kaygılı bağlanmayı pozitif yönde ve kaçınan bağlanmayı negatif yönde yordamıştır. Yeniden örnekleme yöntemi ile yapılan analiz sonuçlarına göre ise yalnızlık benlik saygısı ile kaçınan ve kaygılı bağlanma arasındaki ilişkilerde kısmi aracı rol oynarken duygusal bağımlılığın anlamlı bir aracı rolü bulunmamıştır. Elde edilen bulgular kuramsal temel ve alanyazındaki çalışmalar açısından tartışılmış ve gelecekte yapılabilecek çalışmalar için öneriler sunulmuştur.

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB). Determinants of pulmonary TB disease include gender, and age. The Rapid Molecular Test Method (TCM) is a breakthrough TB program for Drug Resistant TB patients. The TCM method takes two hours to get the patient's diagnosis. TCM method for diagnosing TB and resistance to rifampin quickly and accurately. Tidar Magelang Hospital is one of the referral places for TCM examinations from various health facilities. The purpose of this study was to describe the results of the TCM method of pulmonary TB examination on pulmonary TB suspects at Tidar Magelang Hospital. This type of research is descriptive. The research data is secondary data obtained from Tidar Hospital Magelang. Based on age, namely early adolescence, late adolescence, early adulthood, late adulthood, early elderly, late elderly, and seniors, the results were sensitive rif 0.76%, 11.45%, 9, 54%, 7.25%, 5.73%, 8.78% and 3.82%. Negative results 1.15%, 1.91%, 6.87%, 7.25%, 7.63%, 14.89% and 12.98%. The rif results were sensitive to 27.1% males and 20.23% females. Negative results in 31.3% men and 21.37% women. The most sensitive rif results are in Magelang, followed by Magelang City, then East Jakarta Municipality, Banjarnegara and Purworejo. Negative results were found in Magelang, followed by Magelang City, then Wonosobo and East Waringin City.

BACKGROUND: Adolescence is a period of transition from childhood to early adulthood, an important period because of the rapid development of reproductive organs. The quality of adolescent food consumption in South Tangerang City in 2018 was not appropriate because of consumption less fiber, fruit, and vegetables, consuming foods high in sugar, fast food, and skipping meals, and consuming snacks outside the home. Adolescent eating behavior was also determined through knowledge information and attitude about food originated from parents’ feeding practices that influenced adolescent eating behavior. AIM: This study aims to determine the effect of parents’ feeding practices, eating knowledge, and attitude on eating behavior among senior high school students in South Tangerang. METHODS: The study involved 503 high school students who were selected purposively using the online data collection through convenience sampling technique. The design of this study used a cross-sectional study through an online self-administered method with the help of a questionnaire. Path analysis is used to see the direct and indirect effects using the Statistical Package for the Social Sciences 25.0. RESULTS: The influence test results show that parents feeding practices (PX1 = 0.318*), eating knowledge (PX2 = 0.158*), and eating attitudes (PX3 = *0.022) directly affect students eating behavior. CONCLUSION: There was a significant effect of parents’ feeding practices, knowledge, and eating attitude on the eating behavior.

Background Given the high incidence of perinatal maternal depression, implementation of preventive actions is crucial. In France, two prenatal preventive measures are available to the general population: early prenatal interview (EPI) and antenatal classes (ANC). Objective To explore the independent associations between EPI and / or ANC and maternal depressive symptoms at 2 months postpartum. Method We used data from the Etude Longitudinale Francaise depuis l'Enfance (ELFE), a French national representative cohort of children and their parents, followed-up from birth to early adulthood. Data concerning characteristics were collected from the mothers during the maternity stay and between 6/8 weeks’ post-partum. The level of depressive symptoms was scored by the French version of the Edinburgh Postnatal Depression Scale (EPDS) between 6/8 weeks’ post-partum. We considered EPDS score ≥10 indicative of postnatal psychological distress (PPD) and EPDS ≥12 for postnatal depressive symptoms (PNDS). After data imputation, multivariate logistic regression analysis was performed. Results Among the 16,411 mothers included in our sample, 26% benefited both from EPI and ANC, 31.1 % of ANC, 7.7% of an EPI and 35% of neither; 20,1% presented PPD and 12,1% PNDS. The likelihood of presenting PPD was significantly higher in mothers who had neither had EPI nor ANC (OR = 1.15 (95% CI : 1.01–1.30). There was no association between receiving or not an EPI and/or ANC and presenting PNDS. Conclusions Antenatal preventive measures may be helpful to prevent PPD at 2 months’ post- partum, while PNDS do not seem to be influenced by these actions.

Background: Several sellar and parasellar pathologies affect the size and shape of sella turcica. A deviation from normal dimensions of sella turcica could be an indication of a pathological condition of the structure itself or the pituitary gland. Aim: This study was designed to assess the dimensions and morphology of the sella turcica of Yoruba ethnic population using cranial computed tomography (CT) images. Materials and Methods: This was a retrospective study involving 321 cranial CT images of the Yoruba subjects acquired in a tertiary health institution between January 2020 and April 2021. The sella turcica length, depth and anteroposterior diameter were measured using the digital calipers of the CT system while sella morphological shape was determined qualitatively by observing the floor of sella in the midsagittal slice and quantitatively by taking the ratio of superoinferior diameter to the transverse diameter. Result: In general, the mean and standard deviation value of sella turcica length was 12.2±`2.35mm. The mean sella length for males was 12.62`±2.50 and that for females was 11.69 ±`2.04mm. The result showed that males’ sella length differed significantly from that of females (t=3.635, p=0.000). A significant difference was noted between the sella depths of the two genders (p=0.032). The total mean anteroposterior diameter (APD) of sella turcica was 13.4`± 2.47mm. Male and female mean diameters were 13.6`± 2.45mm and 13.3±`2.17mm respectively. No significant difference was noted in sella length and APD across the age categories but sella depth showed a significant difference, which was noted to only exist between early adulthood (≤34 years) and late adulthood (≥65) (p=0.027). No statistically significant association was noted between sella shape and gender (c2=3.124, p=0.210) as well as age (c2=9.336, p=0.156). Conclusion: Only the mean sella length and depth differ significantly between male and female genders. Anteroposterior diameter is the same irrespective of gender. The sella turcica dimensions obtained from this study will serve as reference values for physicians in the assessment of sellar and parasellar pathologies in the study population. Key words: Computed tomography, sella turcica, morphology.

Background and ObjectivesSporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of human prion disease and typically occurs in middle to late life. sCJD in early adulthood is extremely uncommon. The purpose of this report is to raise awareness of cases of sCJD in young patients that are not associated with a genetic mutation or acquired prion disease risk factors.MethodsWe describe the clinical presentation, diagnostic workup, and postmortem examination of a 22-year-old man with sCJD.ResultsThe patient presented with a rapidly progressive neurocognitive disorder consisting of early and prominent psychiatric symptoms. CSF real-time quaking-induced conversion (RT-QuIC) was indeterminate, and brain MRI was suggestive of prion disease. Neuropathologic examination and the absence of a genetic mutation and acquired prion disease risk factors resulted in a final diagnosis of sCJD.ConclusionAlthough extremely rare, sCJD can occur in young people and should be considered in the setting of rapidly progressive neuropsychiatric conditions. Postmortem examination is required to diagnose the type of prion disease and remains important to surveil for known and potentially novel acquired prion diseases.

Cross-sectional studies have established a variety of structural, synaptic, and cell physiological changes corresponding to critical periods in cortical development. However, the emergence of functional connectivity (FC) in development has not been fully characterized, and hemodynamic-based measures are vulnerable to any neurovascular coupling changes occurring in parallel. We therefore used optical fluorescence imaging to trace longitudinal calcium FC in the awake, resting-state mouse cortex at 5 developmental timepoints beginning at postnatal day 15 (P15) and ending in early adulthood at P60. Calcium FC displayed coherent functional maps as early as P15, and FC significantly varied in connections between many regions across development, with the developmental trajectory’s shape specific to the functional region. Evaluating 325 seed–seed connections, we found that there was a significant increase in FC between P15 and P22 over the majority of the cortex as well as bilateral connectivity and node degree differences in frontal, motor, and retrosplenial cortices after P22. A rebalancing of inter- and intrahemispheric FC and local-distal FC dominance was also observed during development. This longitudinal developmental calcium FC study therefore provides a resource dataset to the field and identifies periods of dynamic change which cross-sectional studies may target for examination of disease states.

PROFILE OF CONDYLOMA AKUMINATA PATIENTS IN THE SKIN AND SEX POLYCLINIC OF PERTAMINA BINTANG AMIN HOSPITAL FOR THE PERIOD OF JANUARY 2016 TO DECEMBER 2019. Introduction : Sexually transmitted infection (STI) is one of the diseases and causes of health, social and economic problems in many countries. According to WHO, more than 1 million sexually transmitted infections are acquired every day in various parts of the world and more than 290 million women have human papillomavirus infection. In America, data from the CDC shows new cases with more than 19.7 million sexually transmitted infections each year, and about 14.1 million cases are human papillomavirus infections. Objective : This study aims to find out information about the profile of condyloma acuminata sufferers at the Dermatology and Venereology Polyclinic at Pertamina Bintang Amin Hospital for the period January 2016 to December 2019. Methods: This study used quantitative descriptive analysis with the aim of knowing the profile of patients with condyloma acuminata. Sampling was done by using the total sampling method. The sample in this study were patients with condyloma acuminata who were treated at the Dermatology and Venereology Polyclinic at Pertamina Bintang Amin Hospital for the period January 2016 to December 2019 totaling 22 patient medical records. Results: It was found that patients with condyloma acuminata were more commonly found in the age group of 26 to 35 years (early adulthood), as many as 9 patients (40.9) in the female sex, namely 17 patients (77.3%) with married status. as many as 17 patients (77.3) while based on the management of patients more were given treatment using electric surgery, namely as many as 8 patients (36.4%). Conclusion : Patients with condyloma acuminata in order to maintain their health condition, and avoid risk factors that can increase the occurrence of condyloma acuminata, it is hoped that health workers can hold health promotion activities about the prevention of sexually transmitted diseases, especially condyloma acuminata and this research can be used as additional information to develop further research regarding the factors that have not been studied in this study Keywords: Condyloma acuminata, sexually transmitted infection, HPV

Background: Reproductive Tract infections (RTIs) in women is one of the wide spread health concerns. Untreated RTIs can lead to adverse health and pregnancy outcomes, so there is a need for education and consultation on it. Aim: This study aimed to assess effect of educational program on knowledge of early adulthood women about RTIs. Methods: Quasi experimental research design was used in this study. It was conducted at gynecological outpatient clinics of South Valley University’s Hospital and General Qena Hospital. Sample included 380 women. Structured interview questionnaire was used and involved four sections (personal, obstetrics, gynecological and RTIs' knowledge). An educational program about RTIs was implemented on early adulthood women. Results: There is statistical significant difference between pre and post intervention regarding total knowledge about RTIs P- values are 0.001. Conclusion: There was an improvement in the total knowledge about RTIs after implementation educational program about RTIs. Recommendations: Planning and implementing educational program as a routine hospital care with providing a booklet about RTIs and its preventive measures to reduce rate of RTIs among women. Keywords: Educational Program, knowledge, Reproductive Tract Infections, Early Adulthood

The majority of mental health disorders have their onset during adolescence and early adulthood, with roughly half of these disorders emerging in mid-adolescence. While sport offers a range of critically important benefits, competitive demands on young athletes may increase susceptibility to mental health symptoms and disorders during an already challenging developmental period, especially in the context of elite sport, which is characterized by increasing professionalization and specialization. This clinical review examines key literature regarding risk factors for mental health symptoms and disorders in youth athletes, as well as providing informed practical guidance for clinicians working with this cohort.

Background Individuals with cystic fibrosis (CF) diagnosed as adults represent a rare but growing subset of the CF population. Limited studies have described their lung function trajectories. Research Question What is the overall trajectory of lung function and clinical characteristics associated with lung function decline in people who receive a diagnosis of CF as adults? Study Design and Methods The Canadian CF Patient Registry (CCFR) was used to identify patients with CF who were ≥ 18 years of age at diagnosis and received a diagnosis between 2000 and 2017. Linear mixed-effects models were used to quantify the change in lung function over age and to examine clinical characteristics associated with lung function decline. Results Lung function was stable in early adulthood, with a decline in middle adulthood (age 30-50 years) and a greater decline after 50 years of age. Individuals who receive a diagnosis at older ages (> 50 years: slope, –0.71%/y; 41-50 years: –0.68%/y; 31-40 years: –0.29%/y; 18-30 years: –0.28%/y) and those demonstrating pulmonary symptoms (slope, –0.41%/y) compared with no pulmonary symptoms at baseline were associated with faster rate of lung function decline. Interpretation The lung function of who receive a diagnosis of CF as adults in the CCFR declines slowly compared with estimates from the overall adult CF population. Individuals with adult-diagnosed CF who are older and demonstrate pulmonary symptoms at diagnosis experience a faster rate of lung function decline and should be monitored more closely.

Background. The physical benefits of fitness for middle-aged women are well-known. Unlike the usual training sessions, aquafitness occupies a special place among the types of health-related exercise training. Its health-enhancing effect results from the activation of the body's functional systems, the gravitational unloading of the musculoskeletal system, high energy expenditures, and overall body hardening effect. The objective of this study was to evaluate the health-enhancing effects of an aquafitness program on the functional indicators and physical fitness of early adulthood women. Materials and methods. Theoretical analysis and generalization of scientific and methodological literature, anthropometric techniques, pedagogical methods, and methods of mathematical statistics were used. The functional status of the body was assessed with the indices characterizing the function of the cardiorespiratory system, which are commonly used. The study was conducted at the Sport Life fitness club, Chernivtsi. The study involved 48 women aged 21-31 with an average age of 26.3 years. The subjects took part in a six-month aquafitness program consisting of 60-min sessions, three times a week. The program was developed by the authors and included aquatic stretching, body shaping and bodybuilding exercise, aquadance, aquatic gymnastics, and aqua tae-bo. Results. After participation in the exercise program: vital capacity increased from 45.96±4.69 to 48.88±0.68; strength index increased from 35.80±1.07 to 43.26±0.71; Robinson's index increased from 85.72±12.34 to 89.63±10.11; Shtange test increased from 30.28±10.32 to 37.78±12.34; Hench test changed from 16.48±4.24 to 25.19±4.58; Kerdo index decreased from 5.23±0.74 to 0.88±0.38; and Rufier's test decreased from 12.21±4.26 to 8.03±2.14. The assessment of somatic health of the women showed a significant improvement (p

Physical and psychiatric health conditions affect the lives of many autistic adults. However, relatively little is known about individual trajectories in autistic individuals' physical and mental health from adolescence to adulthood.This study uses a well-characterized longitudinal sample (Seizure onset continued well into adulthood, with two individuals experiencing their first seizure at the age of 25 years. Seizures and neuropsychiatric medication use were both higher for those with lower intelligence quotient (IQs). In addition, medication use increased over time for these individuals, whereas those with higher IQs saw a reduction in medication use with age. Between the ages of 15 to 30 years, the predicted probability of medication use increased from 82% to 88% for those with lower IQs and decreased from 37% to 13% for those with higher IQs. Collectively, almost 70% of all participants in this study were classified as either overweight or obese. Body mass index (BMI) increased throughout adulthood, especially for those with higher IQs. The steepest increase in BMI over time occurred for those with higher IQs who also took antipsychotic medications.Overall, continued risk for developing seizures, high rates of neuropsychiatric medication use, and significant and increasing rates of obesity from adolescence to adulthood underscore the importance of monitoring health issues in autistic individuals and those diagnosed with other neurodevelopmental conditions throughout the lifespan.Autistic individuals and those diagnosed with other neurodevelopmental conditions are at risk for many physical health issues from adolescence to adulthood. This includes, but is not limited to, seizure disorders, high rates of medication use, and obesity. Yet, not much longitudinal research exists measuring these health issues throughout the lifespan and, especially, in adulthood.The researchers analyzed data from a sample of 253 individuals who lived in North Carolina, Michigan, and Illinois. This sample was recruited almost 30 years ago, beginning the study when they were roughly 2 years old. Some participants had an autism spectrum disorder diagnosis, and some did not, but instead had other neurodevelopmental conditions. The researchers measured changes in medication use, height, and weight beginning in early adolescence (age 10 years) into adulthood (age 30 years). The researchers also tracked seizure occurrences across the life span (beginning at age 2 years up until age 30 years).In adulthood, this sample showed high rates of obesity and medication use. For example, almost 70% of this sample was classified as either overweight or obese. In addition, 55% of this sample was taking at least one neuropsychiatric medication in adulthood, and 22% of this sample was taking three different types of medication at the same time. Individuals with higher and lower intelligence quotient (IQs) had different findings over time: obesity increased throughout adulthood for those with higher IQs and medication use increased throughout adulthood for those with lower IQs. Seizures first developed for a group of individuals in adolescence and adulthood. Two individuals experienced their first seizure as late as 25 years of age.Research, and especially longitudinal research, on physical health in autistic adults is limited. Although we know that autistic individuals generally experience high rates of obesity, seizure disorders, and medication use, less is known about how these physical health issues change over the lifespan. This study has provided useful information regarding how certain physical health issues change over time, and who these physical health issues impact the most in adulthood.The findings in this study identified that, in adulthood, autistic adults experience high rates of physical health issues, including increasing rates of obesity and medication use for certain populations. These findings confirm how important it is for autistic adults to have access to quality health care across the lifespan. We hope that, with these findings in mind, caregivers and health professionals will work to ensure that autistic individuals, from childhood through adolescence and adulthood, will have access and assistance in monitoring these ongoing and persistent health problems.

Purposes: The aims of this study were to investigate the cross-sectional and prospective associations between accelerometer-measured physical activity and cardiometabolic health in the transition to adulthood. Methods: Data from the 1993 Pelotas (Brazil) Birth Cohort were analyzed (n = 2280). Moderate-to-vigorous intensity physical activity (MVPA) (measured using a triaxial accelerometer) and cardiometabolic health (total fat mass, blood glucose, non-high-density lipoprotein cholesterol, triglycerides, and mean resting blood pressure) were examined at age 18 and 22 yr. Results: Overall, inverse dose–response associations between MVPA and cardiometabolic health at age 18 and 22 yr were observed in cross-sectional analyses of data from men and women. Prospective analyses showed that, in general, MVPA declined, and cardiometabolic health worsened in this 4-yr period in both men and women. Cardiometabolic health at age 22 yr reflected both MVPA at age 18 yr (β, −0.007; 95% confidence interval [CI], −0.014 to 0.000) and changes in MVPA from 18 to 22 yr (β, −0.030; 95% CI, −0.043 to −0.016) in men, but only changes in MVPA in women (β, −0.035; 95% CI, −0.058 to −0.011). In analyses of change over time, men who improved MVPA by 20 to 30 min·d−1 showed significant improvements in cardiometabolic health over 4 yr. The magnitude of association was slightly stronger for MVPA in 10-min bouts than for MVPA accumulated in bouts of 1 min, especially in women. Conclusions: Moderate-to-vigorous intensity physical activity is an important predictor of cardiometabolic health in early adulthood. Strategies to prevent declines in MVPA at this life stage are required to prevent deteriorating cardiometabolic health profiles. Associations between Device-measured Physical Activity and Cardiometabolic Health in the Transition to Early Adulthood

I show that serious, yet common, parental health events in childhood have immediate and lasting effects on mental health and educational outcomes for children. Following a parental health event, the children are more likely to receive therapy and consume anti-depressant (AD) medication. More so, the children achieve lower test scores and have lower school enrollment rates. The effect immediately occurs following the event and persists at least into early adulthood. I find that the effect on test scores doesn't differ significantly across family income, but that children from low-income families are more likely to be prescribed ADs following the event, while children from high-income families are more likely to receive therapy. Exploiting differences in general practitioners' behavior in prescribing AD and referring children to therapy, I find suggestive evidence that children who are more exposed to medical treatment of mental health issues have lower educational attainments in early adulthood.

BACKGROUND: Previous research has suggested that vigorous physical activity (VPA) during adolescence and early adulthood is associated with ALS. The National ALS Registry (Registry) collects physical activity data from persons with ALS. OBJECTIVE: To examine the association between vigorous VPA and early onset ALS, defined as a diagnosis before age 60, among patients enrolled in the Registry. VPA was defined as engaging in dynamic exercise for at least 10 minutes in a session that caused heavy sweating or large increases in breathing or heart rate. METHODS: A cross-sectional study was conducted of 5,463 ALS patients with VPA history and 956 ALS patients who never engaged in VPA. Patient characteristics were collected via online surveys in the following areas: demographic, lifetime VPA history, and initial onset of symptoms. General linear modeling was used to estimate mean age of diagnosis and to compute 95% confidence intervals. RESULTS: Patients who reported engaging in VPA at least moderately (three times a week) during early adulthood were more likely to have an ALS diagnosis earlier compared to patients who did not (p

Apsychoactiveorpsychotropic substanceis a chemicalsubstancethat acts primarily uponthe central nervous system, altering mental processes, e.g., cognition or affect.Their use can lead to addiction, so in common language ‘substance abuse’ implicate dependence-producing effect. In general, initiation to substance use happen during adolescence and early adulthood. The aim of this study was determining the pattern of psychoactive substance consumption among students at Faculty of Medicine of Sarajevo University. A cross-sectional study was conducted during May 2019 at Faculty of Medicine of Sarajevo University. The survey covered 102 students, who attended first and fifth year of study. The research instrument was a self-administered anonymous questionnaire. Results were expressed as percentages and means ± standard deviation. During statistical analysis we performed Chi-squared and the bivariate testes. A sample included 102 students, of which 66 (64.7%) were female and 36 (35.3%) were male, while 52 (51.0%) attended first year and 50 (49.0%) attended fifth year. The majority of students (91.2%) had consumed caffeine. Consumption of cigarettes reported 63.7% of students, and consumption of alcohol reported 60.8% of students. Statistically significant differences in consumption of alcohol (P

Solar urticaria is a well-recognized photodermatosis, sometimes accompanied by angioedema. However, isolated solar angioedema (ISA) is a rare and unrecognized entity. The purpose of our work was to systematically review the available data on ISA. Therefore, a systematic review of studies evaluating ISA was performed. Additionally, a case of a 21-years-old patient from our photodermatosis service is presented. The search yielded 421 publications, with 3 eligible for review. Together with our case, 5 cases were included overall. All patients were female. Four out of 5 patients first experienced ISA at childhood or early adulthood (age range 6-22 years). UVA photoprovocation was positive in the 3 out of the 4 patients who were tested. Improvement was noted following NB-UVB hardening (2 out of 5 patients) or a short course of oral prednisone (3 out of 5 patients) combined with regular sunscreen application. To conclude, ISA is an extremely rare entity, although it may be underdiagnosed due to lack of awareness. The clinician must consider ISA in the differential diagnosis of angioedema since it can have a detrimental effect on quality of life. Besides sun avoidance, there is no consensus regarding treatment.

Introduction: Ankylosing spondylitis(AS) is a rheumatic disease that comes under the category of Spondyloarthritides. The symptoms of the disease are usually first noticed in late adolescence or early adulthood, with male to the female prevalence of 3:1. Which can be better managed by a combination of Panchakarma procedures and Ayurveda drugs. Clinical findings - We present a case of AS, having symptoms of low back pain along with stiffness unable to bend forward completely, and pain in the nape of the neck with stiffness and restricted movement so it was considered to be Gambhira Vatarakta. Intervention: Patient was treated with Panchakarma treatment Vaitrana Basti(Enema with medicated drugs) in Kala Schedule for 9 days and Jambeera Pinda Swedana(JPS) for 6 days along with oral medicines. Outcomes - As oral Medication along with Panchakarma procedures help in relieving signs and symptoms like pain and restricted movement and providing best comfort to the patient by reducing the severity of the disability. Conclusion - so it can be concluded that Panchakarma is effective in the management of Ankylosing Spondylitis.

BackgroundExisting evidence on profiles of psychological distress across adulthood uses cross-sectional or longitudinal studies with short observation periods. The objective of this research was to study the profile of psychological distress within the same individuals from early adulthood to early old age across three British birth cohorts.MethodsWe used data from three British birth cohorts: born in 1946 (n= 3093), 1958 (n= 13 250) and 1970 (n= 12 019). The profile of psychological distress – expressed both as probability of being a clinical case or a count of symptoms based on comparable items within and across cohorts – was modelled using the multilevel regression framework.ResultsIn both 1958 and 1970 cohorts, there was an initial drop in the probability of being a case between ages 23–26 and 33–34. Subsequently, the predicted probability of being a case increased from 12.5% at age 36 to 19.5% at age 53 in the 1946 cohort; from 8.0% at age 33 to 13.7% at age 42 in the 1958 cohort and from 15.7% at age 34 to 19.7% at age 42 in the 1970 cohort. In the 1946 cohort, there was a drop in the probability of caseness between ages 60–64 and 69 (19.5%v.15.2%). Consistent results were obtained with the continuous version of the outcome.ConclusionsAcross three post-war British birth cohorts midlife appears to be a particularly vulnerable phase for experiencing psychological distress. Understanding the reasons for this will be important for the prevention and management of mental health problems.

To identify low back pain (LBP) trajectories from early adolescence through to early adulthood and to investigate whether sustained levels of elevated subclinical C-reactive protein (CRP) are linked with these LBP trajectories. We analysed longitudinal data from 1513 participants who were enrolled in the Raine Study cohort. Data on LBP with impact on daily living and CRP were collected at the ages of 14, 17, 20, and 22. We constructed group-based trajectory models to identify discrete trajectories of LBP with impact. We then evaluated how the CRP trajectories and the LBP with impact trajectories evolved jointly over time using a multi-trajectory analysis. The model identified three LBP trajectories. One subgroup included almost half the participants (46.1%) who had a consistently low probability of LBP. Another subgroup comprising 43.5% of participants had an increasing probability of LBP, while one in ten participants (10.4%) had a decreasing probability of LBP. There were no associations between elevated CRP and LBP trajectory subgroup membership. Although young people follow distinct trajectories of LBP, CRP trajectories do not appear to be a distinguishing factor of the LBP trajectories. Previously reported associations between CRP and LBP may be explained by comorbidity or other factors. Future studies undertaking trajectory analysis should consider comorbidity clusters. Diagnostic: individual cross-sectional studies with the consistently applied reference standard and blinding

Background There is evidence that the amygdala undergoes extensive development. The exact nature of this change remains less clear, with evidence suggesting linear, curvilinear, and null effects. The aim of this study was the identification of a normative reference of left and right amygdala development by parceling variance into separate effects of age and longitudinal growth. Methods Data came from the National Institutes of Health MRI Study of Normal Brain Development. Participants in this sample were 54% female and ranged in age from 5 to 18 years (mean = 11.37 years) at study entry. Results As predicted, the age at initial scan moderated the slope of both left and right amygdala volumes, demonstrating that the nature of longitudinal growth varies across age (i.e., steeper slopes observed among those first scanned at an early age). Follow-up analysis showed that the positive longitudinal growth slope becomes nonsignificant at 13.1 years of age for the left amygdala and at 14.5 years for the right amygdala, suggesting that growth of the left amygdala peaks earlier than growth of the right amygdala. Conclusions Findings suggest that rapid increases in volumes at early ages decline as youths enter adolescence and may turn to minor declines in volume during late adolescence or early adulthood.

Background: Although adolescent dietary patterns tend to be of poor quality, it is unclear whether dietary patterns established in adolescence persist into adulthood. Objectives: We examined trajectories across adolescence and early adulthood for 2 major dietary patterns and their associations with childhood and parental factors. Methods: Using data from the Western Australian Pregnancy Cohort (Raine Study), intakes of 38 food groups were estimated at ages 14, 17, 20 and 22 y in 1414 participants using evaluated FFQs. Using factor analysis, 2 major dietary patterns (healthy and Western) were consistently identified across follow-ups. Sex-specific group-based modeling assessed the variation in individual dietary pattern ȥ scores to identify group trajectories for each pattern between ages 14 and 22 y and to assess their associations with childhood and parental factors. Results: Two major trajectory groups were identified for each pattern. Between ages 14 and 22 y, a majority of the cohort (70% males, 73% females) formed a trajectory group with consistently low ȥ scores for the healthy dietary pattern. The remainder had trajectories showing either declining (27% females) or reasonably consistent healthy dietary pattern ȥ scores (30% males). For the Western dietary pattern, the majority formed trajectories with reasonably consistent average scores (79% males, 81% females) or low scores that declined over time. However, 21% of males had a trajectory of steady, marked increases in Western dietary pattern scores over time. A lower maternal education and higher BMI (in kg/m2) were positively associated with consistently lower scores of the healthy dietary pattern. Lower family income, family functioning score, maternal age, and being in a single-parent family were positively related to higher scores of the Western dietary pattern. Conclusions: Poor dietary patterns established in adolescence are likely to track into early adulthood, particularly in males. This study highlights the transition between adolescence and early adulthood as a critical period and the populations that could benefit from dietary interventions.

The article is devoted to the results of a study that revealed significant relationships between responsibility and such phenomena as perfectionism and psychological well-being of the individual. The results of the study allow us to attribute responsibility to the fundamental properties of the individual. The formation of responsible behavior is associated with normal (healthy) perfectionism and a subjective sense of well-being. Low levels of responsibility reveal a link with neurotic perfectionism and personality in General. At the same time, it was found that a high level of responsibility can occur with neurotic perfectionism and a low level of well-being.

Background: Exclusive breastfeeding has important role in ensuring adequate nutrition, stunting prevention, and child development. The success rate of exclusive breastfeeding in the World is only (38%), Indonesia (65.1%), Central Java (78.5%) and the working area of ​​ Sibela Local Government Clinic of Surakarta (85.4%). Maternal's knowledge level is part of the determinants of success rates in exclusive breastfeeding. Health education is efforts used to increase maternal knowledge about exclusive breastfeeding. Methods: This research is Pre Experiment with One Group Pre-Post Test. The methode of collecting of data is accidental sampling with questionnaire who containing 20 questions. The comparative hypothesis test used Wilcoxon test. Results: from 42 respondents, 22 (52.4%) had high school education, 21 (50%) were housewives, 24 (57.1%) according to the range of early adulthood (26-35 years) and 31 (73.8%) had got education about exclusive breastfeeding from health workers. The comparative hypothesis test results show a significance 0,00 (p value

Objective The aim was to map rates and cumulative incidences of psychiatric disorders during lifetime for siblings to patients with a diagnosis of bipolar disorder compared with the general population. Methods Danish nationwide population-based longitudinal register linkage study including 13,923 unaffected siblings to 19,955 patients with bipolar disorder and 278,460 unaffected control individuals from the general population matched according to year of birth and sex. Follow-up covered 22 years from 1995 to 2017. Results Rates of 'any psychiatric disorder' among siblings compared with control individuals were constantly around twofold increased throughout lifespan whereas there was a bimodal age distribution of hazard ratios of bipolar disorder, unipolar disorder and use of alcohol or psychoactive drugs with the highest hazard ratios up to age 20 and above 60 years of age. Cumulative incidences from age 15 years of any psychiatric disorder were 44.2% at age 80 years for siblings versus 27.6% for control individuals and the corresponding numbers for bipolar disorder was 8.7% for siblings compared with 1.6% for control individuals. Conclusion Strategies to prevent onset of psychiatric illness in individuals with a first-generation family history of bipolar disorder should not be limited to adolescence and early adulthood but should be lifetime, likely with differentiated age-specific strategies.

BackgroundTraumatic experiences are associated with a higher risk of psychotic illnesses, but little is known about potentially modifiable mechanisms underlying this relationship. This study aims to examine whether post-traumatic stress disorder (PTSD) symptoms mediate the relationship between trauma and psychotic experiences (PEs).MethodsWe used data from the Avon Longitudinal Study of Parents and Children to examine whether: PTSD symptoms mediate the relationships between (a) childhood trauma and adolescent PEs (study of adolescent PEs; n = 2952), and (b) childhood/adolescent trauma and PEs in early adulthood (study of adult PEs; n = 2492). We examined associations between variables using logistic regression, and mediation using the parametric g-computation formula.ResultsExposure to trauma was associated with increased odds of PEs (adolescent PEs: ORadjusted 1.48, 95% CI 1.23–1.78; adult PEs: ORadjusted 1.57, 95% CI 1.25–1.98) and PTSD symptoms (adolescent PTSD: ORadjusted 1.59, 95% CI 1.31–1.93; adult PTSD: ORadjusted 1.50, 95% CI 1.36–1.65). The association between PTSD symptoms and PE was stronger in adolescence (ORadjusted 4.63, 95% CI 2.34–9.17) than in adulthood (ORadjusted 1.62, 95% CI 0.80–3.25). There was some evidence that PTSD symptoms mediated the relationship between childhood trauma and adolescent PEs (proportion mediated 14%), though evidence of mediation was weaker for adult PEs (proportion mediated 8%).ConclusionsThese findings are consistent with the hypothesis that PTSD symptoms partly mediate the association between trauma exposure and PEs. Targeting PTSD symptoms might help prevent the onset of psychotic outcomes.

LIFE Child Depression - a prospective longitudinal cohort study on the origin of depressive disorders between childhood and early adulthood LIFE Child Depression is a prospective longitudinal study on the origin and course of depressive symptoms and disorders between child- and adulthood. The aim of the study is to identify patterns of developmental courses of symptoms and disorders and to investigate the interplay of psychosocial, biological and genetic risk and protective factors in the development of depressive disorders. The present paper gives an overview on results of the study. The sample was already assessed three times. A clinical sample was recruited from two local child psychiatric in- and outpatient services in Leipzig, a control sample was recruited from a children's health check program at our medical faculty (LIFE Child Health) and from the local registration office. We found some important context- and parent-associated risk factors for depressive disorders, such as negative life events, low socioeconomic status and depression in mothers (but not in fathers). Moreover, we found some characteristic biological and cognitive-emotional characteristics of children with depressive disorders, such as low stress-related cortisol, low evaluation of own performance, and more negative cognitions in dealing with stressful situations, low self-esteem and a general impairment of emotional processing of human faces. Only some of the risk factors were found to be specific to depression. Instead, most of them can be regarded as general risk factors for psychological disorders in childhood. It is also noteworthy, that some of the risk associations were gender-specific and need to be looked at from a differential point of view. Our study gives important indications for prevention for children at risk for depressive disorders as well as for therapeutic approaches.

Aims: The link between perceived social support and mental health has received much attention from numerous scientific fields in recent years. Most studies, however, have examined associations only over relatively short follow-up periods using global measures of perceived social support and dichotomous negative indicators of mental health. We investigated the long-term association between perceived social support from friends, parents and teachers and multiple positive hedonic and eudemonic indicators of mental health, including hope, meaningfulness and subjective well-being. Methods: This study used questionnaire data from 2004, 2007 and 2010 from the West Jutland Birth Cohort study with linked register data. The study population consisted of 3681 adolescents born in 1989. Multiple linear and ordered logistic regression were used to analyse the association between perceived social support at age 14/15 years and mental health indicators at age 20/21 years while controlling for possible confounders, including the Big Five personality traits and baseline symptoms of depression. Results: The results show that perceived social support from friends in adolescence was positively associated with all indicators of mental health in early adulthood. Furthermore, perceived paternal social support was positively associated with meaningfulness and subjective well-being, while perceived social support from teachers was positively associated with meaningfulness. Conclusions: Overall, the results from this study indicate that perceived social support in adolescence, particularly support from friends, could promote positive mental health outcomes in early adulthood.

Adolescence is a test of new and different behaviors and part of the natural process of separating from parents, gaining acceptance and popularity with peers, developing a sense of identity, autonomy, independence, and maturity, seeking fun and adventure, and or rebelling against authority. Hence, according to the view of some adolescents, engaging in alcohol, tobacco, and the use of other drugs may be seen as a functional way of achieving independence, maturity, or popularity along with other developmental goals. Cannabis is the most commonly used illegal drug in most countries. Many university students are taking cannabis and other illicit drugs. The main objective of this research was to identify the reasons behind the usage of cannabis among Sri Lankan undergraduates, undergraduates’ attitudes towards the use of cannabis, and Cannabis subculture of undergraduates. The purposive sample included six undergraduates who are excessive users of cannabis. Three participants were from the University of Peradeniya and the other three participants were from the University of Colombo. The study used a qualitative research design comprising of semi-structured individual interviews and the data were analyzed using thematic analysis. The results showed that the most influential reasons to use cannabis were, to reduce stress and anxiety, being an early user, the special feeling felt after using cannabis, to enjoy life and due to the freedom afforded at University; to maintain relationships and to build new relationships with others; to be a hero among others, a perceived increase in academic performance and because cannabis is always available at the university premises. It is important to pay attention to this debilitating issue among our future generations.

OBJECTIVE This study tested the hypothesized stress-buffering effects of social support on physical activity, sitting time, and blood lipid profiles. PARTICIPANTS 537 college students. METHODS College students volunteered to self-report stress, social support for exercise, physical activity and sitting time, and provided blood samples to assess lipid profiles in this cross-sectional study. RESULTS Lower stress was associated with higher vigorous physical activity (β = -0.1, t = -2.9, p = .004). Higher social support was associated with higher moderate (β = 0.2, t = 2.0, p = .042), vigorous (β = 0.5, t = 5.4, p

Social anhedonia has been employed in psychometric high risk studies to identify putative schizotypes. The current study reports three-year longitudinal results from a community study of social anhedonia: the Maryland Longitudinal Study of Schizotypy (MLSS). The initial recruitment for the MLSS involved mailed questionnaire screening of 2434 18-year olds. Baseline and three-year follow-up laboratory assessments were subsequently conducted with individuals identified as being high in social anhedonia (N = 79) and a comparison sample (N = 79). Across the assessments both groups showed maturational improvement on all clinical symptom measures with declining symptom severity at the follow-up compared to baseline and there were no group differences in personality disorder diagnoses at follow-up. However, compared to the control group, over the three-year follow-up individuals in the social anhedonia group were found to have elevated schizophrenia-spectrum personality disorder (Cluster A) characteristics, greater negative symptom characteristics, and lower global functioning. The social anhedonia group also had lower educational attainment, higher unemployment, and higher rates of mental health service utilization than did the control group. Within the social anhedonia group, social support and family relationships were cross-sectionally related to symptom severity at follow-up, although social support and family variables from baseline were not predictive of clinical symptom outcomes at follow-up. Results indicate that social anhedonia is associated with persistent schizophrenia-spectrum symptoms and functional impairment in early adulthood.

Aging is a gradual, continuous process of natural change that begins in early adulthood. During early middle age, many bodily functions begin to gradually decline. Aging is a multifaceted biological process that affects all organs and organ systems of the body. Dietary restriction and exercise have been found to extend human lifespan. Exercise, Dietary supplements, antioxidants, preventive intervention can delay aging process. Keywords: lifespan, Longevity, Aging, Oxidative stress, Coenzyme Q10.

Background Moderate to heavy alcohol use during pregnancy (≥3 drinks/occasion) is linked to a range of adverse offspring outcomes. Prior studies suggest that adolescent and young adult mothers may be particularly vulnerable to these risky drinking behaviors during and after pregnancy. This study used latent class growth analysis (LCGA) to examine changes in risky drinking from prepregnancy to postpregnancy and identified prepregnancy predictors representing cognitive and social factors to inform prevention. Methods Participants included 432 adolescent and young adult mothers (aged 13 to 24; 78% Black) assessed annually since childhood in the Pittsburgh Girls Study. Participants prospectively reported frequency of risky drinking (≥3 drinks/occasion) in the year of pregnancy and 2 years before and after pregnancy, as well as social-cognitive risk factors for drinking (alcohol expectancies, drinking motives, caregiver, and peer alcohol use). Results Approximately 11% of young mothers in this community-based sample engaged in risky drinking at least once a month during the year of pregnancy, with greater frequency observed for young adult (vs. adolescent) mothers. LCGA revealed 4 risky drinking trajectories across the perinatal period, including 3 relatively stable trajectories (low, moderate, and high frequency) and 1 distinct trajectory ("postpartum initiators") characterized by increased risky drinking post-childbirth. Peer alcohol use during and after pregnancy distinguished higher risk from lower risk trajectories, controlling for age, race, and age of drinking onset. Exposure to caregiver alcohol use and prepregnancy coping motives for drinking also elevated risk, but only for mothers who became pregnant in early adulthood (vs. adolescence). Conclusions Adolescent and young adult mothers show heterogeneous risky drinking trajectories from prepregnancy to postpregnancy. Pregnant women in the transitional age of early adulthood who report exposure to caregiver alcohol use, more friends who drink, and coping motives for drinking may have elevated risk for moderate-heavy drinking during the perinatal period and may benefit from targeted intervention.

Despite increased attention to the links between the criminal justice system and health, how criminal justice contacts shape health and contribute to racial health disparities remains to be better understood. Using data from the National Longitudinal Study of Adolescent to Adult Health (N = 5,488) and several analytic techniques—including a quasi-treatment–control design, treatment-weighting procedures, and mediation analyses—this study examines how criminal justice contacts shape inflammatory and depressive risk and contribute to black–white health gaps. Findings revealed that incarceration is associated with increased C-reactive protein and depressive risk, particularly for individuals who experienced long durations of incarceration. Arrests are also associated with mental health, and mediation analyses showed that racial disparities in arrests and incarceration were drivers of black–white gaps in depressive symptoms. Together, this study provides new evidence of the role of the criminal justice system in shaping health and patterning black–white health gaps from adolescence through early adulthood.

Purpose: To quantitatively describe the structural corneal changes from infancy to early adulthood using ultrasound biomicroscopy. Methods: In this prospective study, 168 ultrasound biomicroscopy images were obtained from 24 healthy eyes of 24 patients who consented and enrolled in the Pediatric Anterior Segment Imaging Innovation Study. Their ages ranged from birth to 26 years. An established ultrasound biomicroscopy imaging protocol including seven views of one eye per patient were obtained and measured using ImageJ software (National Institutes of Health). Twelve corneal structural parameters were measured. Means were compared between younger and older groups. Results: Among the 12 measured structures, 5 demonstrated statistically significant differences ( P < .05) between patients younger than 1 year and patients older than 1 year. The mean values for corneal cross-sectional width and length, central corneal thickness, and radii of curvature (anterior and posterior) were significantly different in patients younger than 1 year. Curvature and limbus-to-limbus dimensions changed more dramatically than thickness and tissue density. When comparing the youngest to oldest subgroups, anterior curvature flattened (6.14 to 7.55 radius), posterior curvature flattened (5.53 to 6.72 radius), angle-to-angle distance increased (8.93 to 11.40 mm), and endothelial cross-sectional distance increased (10.63 to 13.61 mm). Conclusions: Pediatric corneal structures change with age. The most significant changes occur in the first months of life, with additional changes later in childhood. This study further demonstrates the importance of age in pediatric corneal imaging analysis. [ J Pediatr Ophthalmol Strabismus. 2020;57(4):238–245.]

Purpose Poor diet quality is one of the key contributors to poor cardiovascular health and associated morbidity and mortality. This study aimed to assess how the short-term associations between diet quality and metabolic risk factors change with age. Methods This longitudinal, observational study used data from the National Diet and Nutrition Survey (2008–2016) (n = 2024). Diet quality was measured using the Dietary Approaches to Stop Hypertension (DASH) index, fruit and vegetable (F&V) intake, and a F&V biomarker score. We assessed associations between measures of diet quality and a metabolic risk z score (generated from five metabolic risk factors) among those aged 11–60 years, and then tested effect modification by age group (adolescents 11–18 years, young adults 19–35 years, mid-aged adults 36–60 years). Results Analysis across all age groups showed inverse associations between standardised DASH index and metabolic risk z score of − 0.19 (95% CI − 0.26, − 0.11). These associations were moderated by age group, with strong associations seen in mid-aged adults: − 0.27 (95% CI − 0.39, − 0.16), but associations were significantly attenuated in young adults [− 0.10 (95% CI − 0.22, 0.01)] and adolescents [0.03 (95% CI − 0.05, 0.11)]. Similar results were found for F&V intake and F&V biomarker score. Conclusions Short-term associations between diet quality and metabolic risk are not consistent across adolescent and young adult age groups, suggesting that mechanisms by which diet impacts on metabolic risk may be acting differently in younger age groups compared to adults. Further research is warranted using longitudinal study designs and replication in different populations to understand changes in determinants of cardiometabolic health with age.

본 연구는 아동기 외상과 초기 성인기 대인관계문제 간의 관계에서 초기부적응도식과 감정표현불능이 매개효과를 가지는지 살펴보기 위해 구조방정식모형을 사용했다. 선행연구 고찰과 이론적 배경을 바탕으로 아동기 외상을 독립변인으로, 초기 성인기 대인관계문제를 종속변인으로, 초기부적응도식과 감정표현불능을 매개변인으로 하는 연구모형을 설정했다. 모델을 평가하기 위하여 초기 성인기 대학생 584명을 대상으로 CTQ-SF와 KIIP-SF, YSQ-SF, KAS 척도를 사용하여 설문조사를 실시했다. 아동기 외상과 초기 성인기 대인관계문제 간의 관계에서 아동기 외상은 직접적으로 대인관계문제에 영향을 미치기보다는 초기부적응도식과 감정표현불능을 통하여 간접적으로 영향을 미치는 것으로 확인되었고, 초기부적응도식의 매개효과가 더 크게 나타났다. 이러한 결과에 근거하여 의의와 후속 연구에 대한 제언을 논의했다.

Objective: The aim of this study was to evaluate and compare the underlying pathologies, demographic and retinal detachment characteristics in pediatric and early adulthood retinal detachment. Methods: Patients with rhegmatogenous, serous, or tractional retinal detachment aged 0–26 years were retrospectively reviewed. The preschool group (n = 4) comprised children aged 0–6 years, the pediatric group (n = 19) comprised children aged 7–16 years, and the early adulthood group (n = 13) aged 17–26 years. Demographic information and retinal detachment characteristics, type of surgery, and intraocular tamponade were analyzed. Postoperatively, the functional outcome, anatomic success, and ocular adverse events were evaluated. Due to the low patient number in the preschool group, statistical analysis was performed for pediatric group and early adulthood group only. Results: All causes of retinal detachment were present in the pediatric group, but only rhegmatogenous retinal detachment in the early adulthood group. In both groups, the main type of surgical intervention was pars plana vitrectomy (pediatric group: 52%, early adulthood group: 38%; p = 0.36). The type of intraocular tamponade varied statistically significantly between the groups (p = 0.014). Silicone oil was the main intraocular tamponade in the pediatric group (48%), whereas no tamponade (54%) followed by gas tamponade (46%) in the early adulthood group. Final attachment rate was similar in both groups (pediatric group: 89%, early adulthood group: 100%; p = 0.35). Re-detachment occurred significantly sooner in the pediatric group (1.3 ± 0.3 months) than in the early adulthood group (4.3 ± 1.4 months; p = 0.03). Conclusion: In pediatric and early adulthood retinal detachment, pars plana vitrectomy appeared as a successful surgical intervention. Re-attachment rate and re-treatment were similar in both groups with a better functional outcome observed in cases of retinal detachment in early adulthood and poorer results in young children.