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Background and Objective: Acute myocardial infarction (AMI) is a serious and life-threatening disease caused by a sudden blockage of blood flow in the heart muscle. According to the contradictory results in studies investigating the levels of chemerin (with the role of enhancing inflammation) and omentin-1 (with anti-inflammatory properties) in patients with diabetes, this study aims to compare the levels of omentin-1 and chemerin in patients with acute myocardial infarction (AMI) with and without diabetes and its relationship with vascular lesions, HbA1c, blood pressure, CRP and serum creatinine. Methods: In this cross-sectional study, a total of 80 AMI patients were randomly included in this study with the age range of 37-79 years old, categorized according to the presence (26 patients) or absence (54 patients) of diabetes and the number of arteries with lesions. The levels of omentin-1 and chemerin were measured using ELISA kits, and correlations between the adipokines and other parameters were evaluated using Pearson correlation analysis. ROC curve analysis was performed to assess the diagnostic value of omentin-1 and chemerin in distinguishing AMI patients with and without diabetes. Findings: The demographic characteristics of patients of the two groups, including age, systolic and diastolic blood pressure showed non-significant differences. The levels of omentin-1 were not significantly different between AMI patients with and without diabetes, while chemerin levels were significantly higher in AMI patients with diabetes (1.212±0.232) as compared to the AMI patients without diabetes (0.72±0.116) (p

BACKGROUND: Serum glucose levels can get close to a normal level by an appropriate diet. The present study aims to investigate the effect of low-calorie diets (1200, 1500, 1800 Kcal) on glucose and lipid levels, and HbA1C serum levels of newly diagnosed type II diabetic patients. MATERIALS AND METHODS: This prospective cross-sectional study was conducted among 68 patients with type II diabetes mellitus, whose disease was recently diagnosed. The study criteria included fasting blood glucose higher than 126 mg/dL, HbA1c higher than 7% and BMI higher than 25. Fasting blood glucose levels, 2-hour post-prandial blood sugar and blood lipids were measured before and after intervention. Then, the patients were trained by an expert. After completing the questionnaires, the data were analyzed. RESULTS: In this study, the mean fasting blood glucose level in patients who used 1200, 1500 and 1800 kcal diets decreased significantly after intervention (p

Objective: Diabetes mellitus is the most common chronic endocrine disease worldwide. Intensive glycemic control plays an important role in decreasing morbidity and mortality rate of the disease. Preclinical studies have shown that biotin has an essential role in regulating blood glucose and serum lipid metabolism. This study aims to evaluate the effect of biotin on glycemic control and plasma lipids concentrations in type 1diabetic patients.Methods: This randomized double-blind placebo-controlled clinical trial study was conducted 70 type 1 diabetic patients with an age range 5-25 years old with poorly controlled (glycosylated hemoglobin ≥8%). Subjects were randomly allocated into two groups. In the intervention group biotin (40 microgram/kg) was administered plus daily insulin, while the control group received placebo plus daily insulin regimen for three months. Laboratory tests including glycosylated hemoglobin (HbA1c), fasting blood sugar and plasma lipids were measured at the base and after 3 months.Results: In this study, seventy patients were evaluated, 35 were allocated to each group. There were no statistically significant differences between age, gender, duration of diabetes, BMI and BP between the two groups (p>0.05). HbA1c in the intervention (biotin) group was 9.84±1.80 at base and after 3 months treatment, it declined to 8.88±1.73 (p