179 results on '"tardive dystonia"'
Search Results
2. The effect of antipsychotic-induced extrapyramidal disorders on patient’s compliance with schizophrenia (a clinical case)
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Alexander Kornetov, Arkady V. Semke, EKATERINA DMITRIEVA, Anastasya Goncharova, and Elena Kornetova
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schizophrenia ,tardive dyskinesia ,tardive dystonia ,Molecular Medicine ,Medicine ,akathisia ,compliance - Abstract
Extrapyramidal disorders are common adverse events in antipsychotic therapy. However, their diagnosis is difficult due to broad differential diagnosis, and often their specific clinical variant is not recognized, and timely intervention is not performed, which leads to severe patient suffering. This affects the quality of life of patients with schizophrenia and leads to their refusal to receive therapy, which aggravates the course of the disease. The article presents a clinical case of a 33-year-old patient at a psychiatric hospital with schizophrenia combined with such rare severe extrapyramidal disorders as antipsychotic-induced tardive dyskinesia and tardive dystonia.The diagnosis was carried out in accordance with the criteria of the International Classification of Diseases, Tenth Revision (ICD-10). The intensity of clinical manifestations was assessed using the Positive and Negative Syndrome Scale (PANSS), the Abnormal Involuntary Movement Scale (AIMS), and the Barnes Akathisia Rating Scale (BARS). Compliance was assessed using the Method for Measuring Medication Adherence in Psychiatry. Detailed differential diagnosis of tardive dyskinesia and tardive dystonia with akathisia and Huntington’s disease was presented. Substantiated treatment strategy and positive clinical dynamics with increased compliance were described. more...
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- 2022
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3. Early Remission in Focal Tardive Dystonia Associated with the Use of Neuroleptic Medication: A Rare Case Report and Review of Literature
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Gulsen Aykol and Neslihan Cansel
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Tardive dystonia ,neuroleptic ,early remission ,physical therapy ,Medicine - Abstract
Tardive dystonia is a movement disorder which develops with twisting of one part of the body or abnormal posture because of severe muscle contractions. The most important factor in the occurrence of tardive dystonia is the use of antipsychotic medication. Tardive dystonia associated with long-term use of antipsychotic drugs may be focal, segmental or generalised. When tardive dystonia has occurred once, there is a tendency for it to be permanent and complete recovery is rare. The aim of this paper was to present a case of neuroleptic drug-associated tardive dystonia with focal involvement where early remission was observed and thus draw attention to the necessity of considering physical therapy approaches in addition to medication in the treatment choices. [Med-Science 2015; 4(1.000): 2013-23] more...
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- 2015
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4. Olanzapine-induced Concurrent Tardive Dystonia and Tardive Dyskinesia in Schizophrenia with Intellectual Disability: A Case Report
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Boung Chul Lee, Young Min Choe, Guk Hee Suh, So Yeon Kim, Dong Young Lee, Ihn-Geun Choi, and Jee Wook Kim
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Olanzapine ,Psychosis ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Intellectual disability ,Atypical antipsychotic ,Case Report ,Tardive dyskinesia ,Tardive dystonia ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,medicine ,0501 psychology and cognitive sciences ,Pharmacology (medical) ,Antipsychotic ,Psychiatry ,Clozapine ,business.industry ,05 social sciences ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Schizophrenia ,business ,050104 developmental & child psychology ,medicine.drug - Abstract
Tardive dystonia and tardive dyskinesia (TDs) are rare extrapyramidal side effects that develop after long-term use of antipsychotics, but they are different syndromes and rarely occur at the same time. Olanzapine is an atypical antipsychotic drug associated with a low risk of extrapyramidal side effects in schizophrenia, but its associations with tardive movements are not clear. We present a case of a 19-year-old Asian female patient with schizophrenia and intellectual disabilities who developed concurrent TDs after long-term use of olanzapine. At her 10-month follow-up examination, her concurrent TDs had been treated successfully with clozapine. This case demonstrates that although the use of olanzapine to treat psychosis and behavioral disturbances is increasing due to its high efficacy and low rate of extrapyramidal side effects, concurrent TDs should be carefully assessed after long-term use of this antipsychotic, especially in patients with schizophrenia and intellectual disabilities. Clozapine, by preventing or reversing the debilitating consequences of concurrent TDs, may be an effective treatment for these patients. more...
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- 2020
5. Drug-Induced Movement Disorders and Its Associated Factors Among Patients Attending Treatment at Public Hospitals in Eastern Ethiopia
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Niguse Yigzaw, Tadesse Misgana, and Getachew Asfaw
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Drug ,medicine.medical_specialty ,Movement disorders ,business.industry ,media_common.quotation_subject ,Logistic regression ,Tardive dyskinesia ,medicine.disease ,Akathisia ,030227 psychiatry ,03 medical and health sciences ,0302 clinical medicine ,Extrapyramidal symptoms ,Rating scale ,Internal medicine ,medicine ,Tardive Dystonia ,medicine.symptom ,business ,030217 neurology & neurosurgery ,media_common - Abstract
Background Antipsychotic medications have both beneficial and undesired effects at a dose used for treatment purposes. Among undesired effects caused by antipsychotics, movement disorders are prevalent. However, there is no study done to determine the prevalence of movement disorders that occurred due to antipsychotics and their determinants in eastern Ethiopia. Objective This study aimed to find out the prevalence of drug-induced movement disorders and its determinants among patients who had been on follow-up at public hospitals in eastern Ethiopia. Methods A cross-sectional study was conducted from May to June 2018 at HFSUH and Jugal hospital. Extrapyramidal symptom rating scale (ESRS) was used to identify patients with drug-induced movement disorders in a sample of 411 outpatients. A systematic random sampling method was used to select the sample. Logistic regression was done to identify factors associated. Results A drug-induced movement disorder was found in 44% of the participants: Of this, 27.3% had drug-induced pseudo-Parkinsonism, 21.2% had drug-induced akathisia, 9.5% had drug-induced tardive dyskinesia, and 3.4% had drug-induced tardive dystonia. Being female was associated with pseudo-Parkinsonism (AOR=3.6, 95% CI: 2.03, 6.35), akathisia (AOR=4.9, 95% CI: 2.73, 8.78), and tardive dyskinesia (AOR=2.51, 95% CI: 1.08, 5.86) and being male with tardive dystonia (AOR=4.6, 95% CI: 1.8, 18.5). Alcohol use was associated with tardive dyskinesia (AOR= 5.89, 95% CI: 2.20, 15.69). Conclusion Drug-induced movement disorder in this study was high and nearly half of patients on antipsychotic treatment were experiencing it. Age, sex, and doses of antipsychotics were factors associated with all of the types of drug-induced movement disorders. more...
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- 2020
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6. A Low Clozapine Dose Improved Refractory Tardive Dystonia without Exacerbating Psychiatric Symptoms: A Case Report
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Reiji Yoshimura, Yuki Konishi, Atsuko Ikenouchi, Hirofumi Tesen, and Naomichi Okamoto
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medicine.medical_specialty ,clozapine ,business.industry ,Low dose ,Case Report ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,Clozapine Dose ,schizophrenia ,03 medical and health sciences ,0302 clinical medicine ,Refractory ,tardive dystonia ,Schizophrenia ,030221 ophthalmology & optometry ,medicine ,Tardive Dystonia ,business ,Psychiatry ,Clozapine ,medicine.drug - Abstract
Clozapine is recommended for patients with schizophrenia and tardive dystonia (TD); however, the appropriate dose remains unclear. In this case, a low dose (150 mg/day) of clozapine improved refractory TD and further ameliorated psychiatric symptoms. Herein, we report on a 41-year-old female with schizophrenia and TD who was treated with a low clozapine dose. After eight weeks of continuous clozapine at 150 mg/day (16 weeks after clozapine initiation), her TD dramatically improved, and her psychiatric symptoms were relieved. Low clozapine doses could ameliorate refractory TD. However, this effect might require up to several weeks. Clinicians should be patient unless they consider it better to increase the clozapine dose. more...
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- 2021
7. Quality of life outcomes after deep brain stimulation in dystonia: A systematic review
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Takashi Tsuboi, Michael S. Okun, Adolfo Ramirez-Zamora, and Joshua K. Wong
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Adult ,0301 basic medicine ,medicine.medical_specialty ,Deep brain stimulation ,Adolescent ,Deep Brain Stimulation ,medicine.medical_treatment ,MEDLINE ,Cochrane Library ,Motor symptoms ,Article ,Cerebral palsy ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Quality of life ,Outcome Assessment, Health Care ,otorhinolaryngologic diseases ,medicine ,Humans ,Tardive Dystonia ,Child ,Aged ,Dystonia ,business.industry ,Middle Aged ,medicine.disease ,humanities ,nervous system diseases ,030104 developmental biology ,Neurology ,Dystonic Disorders ,Quality of Life ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery - Abstract
Dystonia is an incurable movement disorder which can cause not only physical but also mental problems, leading to impaired health-related quality of life (HRQoL). For patients with dystonia refractory to medical treatment, deep brain stimulation (DBS) is a well-established surgical treatment. The objective of this systematic review is to provide a better understanding of HRQoL outcomes after DBS for dystonia. A search of the literature was conducted using Medline (PubMed), Embase, and Cochrane Library databases in May 2019. HRQoL outcomes after DBS along with motor outcomes were reported in a total of 36 articles involving 610 patients: 21 articles on inherited or idiopathic isolated dystonia, 5 on tardive dystonia, 3 on cerebral palsy, 2 on myoclonus-dystonia, 1 on X-linked dystonia-parkinsonism, and 3 on mixed cohorts of different dystonia subtypes. DBS improved motor symptoms in various subtypes of dystonia. Most studies on patients with inherited or idiopathic isolated dystonia showed significant improvement in physical QoL, whereas gains in mental QoL were less robust and likely related to the complexity of associated neuropsychiatric problems. HRQoL outcomes beyond 5 years remain scarce. Although the studies on patients with other subtypes of dystonia also demonstrated improvement in HRQoL after DBS, the interpretation is difficult because of a limited number of articles with small cohorts. Most articles employed generic measures (e.g. Short Form Health Survey-36) and this highlights the critical need to develop and to utilize sensitive and disease-specific HRQoL measures. Finally, long-term HRQoL outcomes and predictors of HRQoL should also be clarified. more...
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- 2020
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8. Deep Brain Stimulation of the Globus Pallidus Internus for Secondary Dystonia: Clinical Cases and Systematic Review of the Literature Regarding the Effectiveness of Globus Pallidus Internus versus Subthalamic Nucleus
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Sait Ozturk, Ersoy Kocabicak, Yasin Temel, and Dursun Aygün
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Deep brain stimulation ,medicine.medical_treatment ,Deep Brain Stimulation ,CEREBRAL-PALSY ,Stimulation ,Target selection ,GENERALIZED DYSTONIA ,Globus Pallidus ,Globus pallidus internus ,KINASE-ASSOCIATED NEURODEGENERATION ,Cerebral palsy ,BASAL GANGLIA ,Subthalamic Nucleus ,Basal ganglia ,otorhinolaryngologic diseases ,Medicine ,Humans ,Dystonia ,business.industry ,TARDIVE DYSTONIA ,MICROELECTRODE RECORDINGS ,medicine.disease ,nervous system diseases ,LONG-TERM BENEFIT ,Subthalamic nucleus ,surgical procedures, operative ,Treatment Outcome ,nervous system ,Anesthesia ,Surgery ,MEIGE SYNDROME ,Neurology (clinical) ,NEURONAL-ACTIVITY ,business ,FOLLOW-UP ,Meige Syndrome - Abstract
Objective Deep brain stimulation (DBS) is a frequently applied therapy in primary dystonia. For secondary dystonia, the effects can be less favorable. We share our long-term findings in 9 patients with severe secondary dystonia and discuss these findings in the light of the literature. Methods Patients who had undergone globus pallidus internus (GPi)-DBS for secondary dystonia were included. Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) scores, clinical improvement rates, follow-up periods, stimulation parameters and the need for internal pulse generator replacements were analyzed. The PubMed and Google Scholar databases were searched for articles describing GPi-DBS and subthalamic nucleus (STN)-DBS only for secondary dystonia cases. Keywords were “dystonia,” “deep brain stimulation,” “GPi,” “dystonia,” “deep brain stimulation,” and “STN.” Results A total of 9 secondary dystonia patients (5 male, 4 female) had undergone GPi-DBS with microelectrode recording in our units. The mean follow-up period was 29 months. The average BFMDRS score was 58.2 before the surgery, whereas the mean value was 36.5 at the last follow-up of the patients (mean improvement, 39%; minimum, 9%; maximum, 63%). In the literature review, we identified 264 GPi-DBS cases (mean follow-up, 19 months) in 72 different articles about secondary dystonia. The mean BFMDRS improvement rate was 52%. In 146 secondary dystonia cases, reported in 19 articles, STN-DBS was performed. The average follow-up period was 20 months and the improvement in BFMDRS score was 66%. Conclusions Although GPi-DBS has favorable long-term efficacy and safety in the treatment of patients with secondary dystonia, STN seems a promising target for stimulation in patients with secondary dystonia. Further studies including a large number of patients, longer follow-up periods, and more homogenous patients are necessary to establish the optimal target for DBS in the management of secondary dystonias. more...
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- 2021
9. Deep brain stimulation in Fragile X syndrome with tardive dystonia
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Tommaso Tufo, Anna Rita Bentivoglio, Carla Piano, Francesco Bove, and Pietro Chiurazzi
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medicine.medical_specialty ,Pediatrics ,Neurology ,Deep brain stimulation ,business.industry ,medicine.medical_treatment ,Dermatology ,General Medicine ,medicine.disease ,Fragile X syndrome ,Psychiatry and Mental health ,medicine ,Neurology (clinical) ,Tardive Dystonia ,Neurosurgery ,business ,Neuroradiology - Published
- 2021
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10. Tardive Dystonia and Dyskinesia Responsive to Deep Brain Stimulation
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Shannon Y. Chiu and Irene A. Malaty
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Deep brain stimulation ,business.industry ,medicine.medical_treatment ,nervous system diseases ,surgical procedures, operative ,nervous system ,Dyskinesia ,otorhinolaryngologic diseases ,medicine ,Tardive Dystonia ,medicine.symptom ,business ,therapeutics ,Neuroscience - Abstract
Tardive disorders encompass phenomenologically diverse delayed-onset persistent involuntary motor symptoms associated with exposure to dopamine receptor blocking agents. Two common tardive disorders encountered in the clinical setting include tardive dyskinesia and tardive dystonia. This chapter presents a patient with severe refractory tardive dyskinesia and also tardive dystonia, manifesting as frequent and disabling retropulsion. He initially underwent bilateral globus pallidus interna (GPi) deep brain stimulation (DBS) but was found to have lead migration secondary to his severe hyperkinetic movements. He had persistent symptoms despite lead revision and ultimately required bilateral subthalamic nucleus (STN) rescue DBS implantation. The rescue procedure was synergistic with the initial GPi DBS and markedly improved his symptoms. Severe tardive dyskinesia and dystonia may respond to bilateral GPi DBS, and if necessary, rescue STN DBS can be added. more...
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- 2020
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11. Speech-Induced Task-Specific Cranio-Cervical Tardive Dystonia: An Unusual Phenomenology
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Vikram V. Holla
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medicine.medical_specialty ,Neurology ,business.industry ,Task-Specific Dystonia ,lcsh:RC346-429 ,Task (project management) ,lcsh:RC321-571 ,medicine ,Neurology (clinical) ,Tardive Dystonia ,business ,Phenomenology (particle physics) ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Letter to the Editor ,lcsh:Neurology. Diseases of the nervous system ,Cognitive psychology - Published
- 2020
12. Tardive dystonia improved with discontinuation of trazodone in an elderly schizophrenia patient: a case report
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Michiko Takayama, Yoshinori Kadota, Naotoshi Ohara, Chikako Okabe, and Hikaru Hori
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medicine.medical_specialty ,Pediatrics ,congenital, hereditary, and neonatal diseases and abnormalities ,Insomnia ,lcsh:RC435-571 ,Case Report ,Tardive dystonia ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Psychiatry ,mental disorders ,medicine ,otorhinolaryngologic diseases ,Psychiatric hospital ,Psychiatry ,Dystonia ,business.industry ,Trazodone ,Delirium ,medicine.disease ,030227 psychiatry ,Discontinuation ,nervous system diseases ,Psychiatry and Mental health ,Schizophrenia ,Antidepressant ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Geriatric psychiatry ,medicine.drug - Abstract
Background Tardive dystonia associated with antidepressant use is rare and often under-recognized. We had an experience with trazodone, which is used for delirium and insomnia prescribed in general hospital, inducing tardive dystonia. Case presentation A 61-year-old Japanese woman had been treated for schizophrenia. She was moved to general hospital because of consciousness disturbance. She was prescribed trazodone (25 mg/day) for delirium and insomnia. After she was discharged, she returned to the psychiatric hospital with tardive dystonia. Her dystonia symptoms improved with 3 days of discontinuing trazodone. Conclusion In the present case, long-term use of trazodone induced tardive dystonia. Discontinuing trazodone rapidly improved tardive dystonia. more...
- Published
- 2020
13. Neurostimulation in tardive dystonia/dyskinesia: A delayed start, sham stimulation-controlled randomized trial
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Christoph Schrader, Alfons Schnitzler, Andreas Kupsch, Joerg Mueller, Joachim K. Krauss, Günther Deuschl, Martin Südmeyer, Jan Vesper, Christine Winter, Jan-Uwe Müller, Jens Volkmann, Doreen Gruber, Daniela Falk, Gerd-Helge Schneider, and Werner Poewe more...
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Adult ,Male ,Time Factors ,Movement disorders ,Deep brain stimulation ,Stereotactic surgery ,Deep Brain Stimulation ,medicine.medical_treatment ,Biophysics ,Globus Pallidus ,Tardive dystonia ,lcsh:RC321-571 ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,otorhinolaryngologic diseases ,medicine ,Clinical endpoint ,Humans ,Tardive Dyskinesia ,Single-Blind Method ,030212 general & internal medicine ,Neurostimulation ,Adverse effect ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Dystonia ,business.industry ,General Neuroscience ,Middle Aged ,medicine.disease ,Generalized and segmental dystonia ,Implantable Neurostimulators ,Treatment Outcome ,Dyskinesia ,Anesthesia ,Female ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Introduction Growing evidence suggests that pallidal deep brain stimulation represents a potential new therapeutic avenue in tardive dystonia/dyskinesia, but controlled and blinded randomized studies (RCT) are missing. The present RCT compares dystonia/dyskinesia severity of pallidal neurostimulation in patients with tardive dystonia using a delayed-start design paradigm. Methods Dystonia/dyskinesia severity was assessed via blinded videos following pallidal neurostimulation at 3 (blinded phase) and 6 months (open extension phase). Primary endpoint was the percentage change of dystonia severity (Burke-Fahn-Marsden-Dystonia-Rating-Scale, BFMDRS) at 3 months between active vs. sham neurostimulation using blinded-video assessment. Secondary endpoints comprised clinical rating scores for movement disorders. Clinicaltrials.gov NCT00331669. Results Twenty-five patients were randomized (1:1) to active (n = 12) or sham neurostimulation (n = 13). In the intention-to-treat analyses the between group difference of dystonia severity (BFMDRS) between active vs. sham stimulation was not significant at 3 months. Three months post-randomisation dystonia severity improved significantly within the neurostimulation by 22.8% and non-significantly within the sham group (12.0%) compared to their respective baseline severity. During the open-label extension with both groups being actively treated, significant and pronounced improvements of 41.5% were observed via blinded evaluation. Adverse events (n = 10) occurred in 10/25 of patients during the 6 months, mostly related to surgical implantation of the device; all resolved without sequelae. Conclusion The primary endpoint of this randomized trial was not significant, most likely due to incomplete recruitment. However, pronounced improvements of most secondary endpoints at 3 and 6 months provide evidence for efficacy and safety of pallidal neurostimulation in tardive dystonia. more...
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- 2018
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14. Antipsychotika-induzierte tardive Bewegungsstörungen – Fallbeispiel einer tardiven Dystonie unter Aripiprazol und Literaturübersicht
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Martina Pitzer, Thomas Stammschulte, and Guido Engelmann
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Pediatrics ,medicine.medical_specialty ,Movement disorders ,business.industry ,General Medicine ,medicine.disease ,Tardive dyskinesia ,Tourette syndrome ,030227 psychiatry ,03 medical and health sciences ,Psychiatry and Mental health ,Clinical Psychology ,0302 clinical medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Aripiprazole ,Tardive Dystonia ,Differential diagnosis ,medicine.symptom ,business ,Adverse effect ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Zusammenfassung. Extrapyramidalmotorische Nebenwirkungen (EPMS) werden im Vergleich zu Antipsychotika der ersten Generation (FGA) unter Antipsychotika der zweiten Generation (SGA) seltener beschrieben. Dies scheint bei Erwachsenen auch tardive Dyskinesien (TDs) einzuschließen, jedoch nicht tardive Dystonien (TDts). Bei Kindern und Jugendlichen wurde unter FGA eine TD seltener beobachtet als bei Erwachsenen. Zur TDt existieren keine Daten. Unter SGA finden sich zu tardiven Bewegungsstörungen bei Kindern und Jugendlichen nur wenige und widersprüchliche Angaben. SGA unterscheiden sich in ihrem Nebenwirkungsprofil. Dabei verursacht Aripiprazol zwar weniger metabolische und kardiale Nebenwirkungen, verglichen mit anderen SGA bei Kindern und Jugendlichen jedoch relativ häufig EPMS. Bisher wurden TDs oder TDts unter Aripiprazol nur bei Erwachsenen beschrieben. Anhand des Fallberichts einer TDt unter Aripiprazol bei einer 13-jährigen Patientin werden Symptomatik, Differentialdiagnostik, Pathophysiologie, Prävalenz und Therapie tardiver Dystonien dargestellt. Unter Medikation mit SGA sollte das mögliche Auftreten von EPMS einschließlich tardiver Bewegungsstörungen berücksichtigt und klinisch regelmäßig überprüft werden. more...
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- 2017
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15. Risperidone-induced tardive dystonia in 10 years old boy and efficacy of aripiprazole: a case report
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Tuna Ozmen, Cicek Hocaoglu, and Ayla Uzun Cicek
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Psychiatry and Mental health ,Pediatrics ,medicine.medical_specialty ,Risperidone ,business.industry ,Medicine ,Aripiprazole ,Neurology (clinical) ,Tardive Dystonia ,business ,medicine.drug - Published
- 2020
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16. Long-Term Follow-Up of 12 Patients Treated with Bilateral Pallidal Stimulation for Tardive Dystonia
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Hiroshi Koyama, Kazuhisa Miyake, Koji Fujita, Ryosuke Miyamoto, Yuishin Izumi, Hideo Mure, Yasushi Takagi, Ryoma Morigaki, Taku Matsuda, Satoshi Goto, and Ryuji Kaji
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Deep brain stimulation ,Side effect ,Long term follow up ,medicine.medical_treatment ,Science ,long-term follow-up ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,Refractory ,Medicine ,Tardive Dystonia ,Ecology, Evolution, Behavior and Systematics ,Dystonia ,business.industry ,globus pallidus internus ,Paleontology ,medicine.disease ,Globus pallidus internus ,030227 psychiatry ,nervous system diseases ,deep brain stimulation ,tardive dystonia ,Space and Planetary Science ,Anesthesia ,business ,030217 neurology & neurosurgery - Abstract
Tardive dystonia (TD) is a side effect of prolonged dopamine receptor antagonist intake. TD can be a chronic disabling movement disorder despite medical treatment. We previously demonstrated successful outcomes in six patients with TD using deep brain stimulation (DBS), however, more patients are needed to better understand the efficacy of DBS for treating TD. We assessed the outcomes of 12 patients with TD who underwent globus pallidus internus (GPi) DBS by extending the follow-up period of previously reported patients and enrolling six additional patients. All patients were refractory to pharmacotherapy and were referred for surgical intervention by movement disorder neurologists. In all patients, DBS electrodes were implanted bilaterally within the GPi under general anesthesia. The mean ages at TD onset and surgery were 39.2 ± 12.3 years and 44.6 ± 12.3 years, respectively. The Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS) performed the preoperative and postoperative evaluations. The average BFMDRS improvement rate at 1 month postoperatively was 75.6 ± 27.6% (p <, 0.001). Ten patients were assessed in the long term (78.0 ± 50.4 months after surgery), and the long-term BFMDRS improvement was 78.0 ± 20.4%. Two patients responded poorly to DBS. Both had a longer duration from TD onset to surgery and older age at surgery. A cognitive and psychiatric decline was observed in the oldest patients, while no such decline ware observed in the younger patients. In most patients with TD, GPi-DBS could be a beneficial therapeutic option for long-term relief of TD. more...
- Published
- 2021
17. Surgical Treatment of Tardive Dystonia in Nepal: A Case Report
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Takaomi Taira, Sudan Dhakal, Pranaya Shrestha, Samir Acharya, Basant Pant, Resha Shrestha, and Pravesh Rajbhanari
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Dystonia ,congenital, hereditary, and neonatal diseases and abnormalities ,Deep brain stimulation ,business.industry ,medicine.medical_treatment ,lcsh:Surgery ,lcsh:RD1-811 ,Antipsychotic treatment ,medicine.disease ,nervous system diseases ,deep brain stimulation ,lcsh:RC321-571 ,tardive dystonia ,Anesthesia ,Long period ,medicine ,otorhinolaryngologic diseases ,Pallidotomy ,In patient ,Tardive Dystonia ,pallidotomy ,business ,Surgical treatment ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry - Abstract
Tardive dystonia is a subtype of dystonia which is seen in patients receiving antipsychotic treatment for long period. Medical treatment of tardive dystonia is very complex and many cases do not respond well to currently available treatment and sometimes can be irreversible. Surgical treatments like pallidotomy and Deep Brain Stimulation (DBS) have shown some promising results. We report this case of Tardive Dystonia who benefitted from Pallidotomy. We believe this is the first case in Nepal.Nepal Journal of Neuroscience 12:81-84, 2015 more...
- Published
- 2016
18. Tardive Dystonia Related with Aripiprazole
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Kyoung-Uk Lee, Sunghwan Kim, Seung-Yup Lee, and Minseob Kim
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Olanzapine ,Pediatrics ,medicine.medical_specialty ,Schizoaffective disorder ,medicine.drug_class ,Aripiprazole ,Case Report ,Tardive dystonia ,03 medical and health sciences ,0302 clinical medicine ,Antipsychotic Agent ,medicine ,Tardive Dystonia ,Clozapine ,Biological Psychiatry ,Benzodiazepine ,business.industry ,Ginkgo biloba ,medicine.disease ,First generation ,030227 psychiatry ,Psychiatry and Mental health ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Tardive dystonia is characterized by sustained, generally slow involuntary twisting movements. It is estimated to occur at a frequency of 1% to 4% among patients who are taking an antipsychotic agent. Unlike the first generation antipsychotics, the second generation antipsychotics are less likely to cause neuroleptic-induced movement disorder. For aripiprazole, only a few cases have been reported for tardive dystonia. We present a young male, who developed a severe tardive dystonia after taking aripiprazole for 5 years. The patient was admitted to for the treatment of both hisdystonic and psychotic symptoms. Olanzapine was administered instead of aripiprazole and while his psychotic symptoms improved, the dystonic symptoms were continued. Therefore, olanzapine was switched to clozapine while augmenting with benzodiazepine, anti-cholinergic, and ginko biloba to control his tardive dystonia. After 2 weeks of treatment, the dystonic movement decreased remarkably. more...
- Published
- 2017
19. Treatment of Dystonia: Deep Brain Stimulation
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Michael H. Pourfar
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Dystonia ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Deep brain stimulation ,business.industry ,medicine.medical_treatment ,medicine.disease ,nervous system diseases ,Physical medicine and rehabilitation ,otorhinolaryngologic diseases ,Medicine ,Tardive Dystonia ,Management principles ,Hereditary Dystonia ,business ,Secondary Dystonia - Abstract
Deep brain stimulation (DBS) currently has FDA humanitarian device exemption status for the management of hereditary dystonia but is frequently used for a variety of nongenetic forms of dystonia including isolated, adult-onset dystonia and tardive dystonia. The degree and latency of improvement following DBS can be highly variable, particularly for secondary forms of dystonia, with some patients responding almost immediately and others requiring several months before any benefit is achieved. Despite these challenges, the management principles of DBS for primary and secondary dystonia are similar in terms of programming parameters and approach to adjustments. more...
- Published
- 2019
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20. Tardive Dystonia due to D2 Antagonists and Other Agents
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Adamantia Giamarelou, Evangelia-Eirini Tsermpini, Athanasios Gogos, Philippos Gourzis, and Maria Skokou
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business.industry ,InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL ,Medicine ,Tardive Dystonia ,business ,Bioinformatics ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) - Published
- 2018
21. Management of aripiprazole-induced tardive Pisa syndrome
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Marco Di Nicola, Alfonso Fasano, Mauro Pettorruso, Luisa De Risio, Luigi Janiri, and Giovanni Martinotti
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Adult ,Pediatrics ,medicine.medical_specialty ,Movement disorders ,anticholinergic drugs ,Settore MED/25 - PSCHIATRIA ,Treatment outcome ,Aripiprazole ,Axial rotation ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Pharmacology (medical) ,Tardive Dystonia ,Psychiatry ,Movement Disorders ,Optimal treatment ,antipsychotic medications ,movement disorders ,side effects ,tardive dystonia ,Algorithms ,Antipsychotic Agents ,Case Management ,Female ,Psychotic Disorders ,Syndrome ,Treatment Outcome ,Psychiatry and Mental Health ,Case management ,Trunk ,030227 psychiatry ,Psychiatry and Mental health ,medicine.symptom ,Psychology ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Pisa syndrome (PS) is characterized by an abnormally sustained posture with flexion of the body and head to one side and slight axial rotation of the trunk. PS has been related to the use of neuroleptics and is clinically classified as either an acute or a tardive dystonia. This is the first report describing a case of late-onset PS, occurring in a young patient treated with aripiprazole for 2 years. To establish optimal treatment management, we reviewed the literature on aripiprazole-induced PS and tardive dystonia. In light of current knowledge, we proposed a multistep algorithm to aid in the clinical management of this condition. more...
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- 2016
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22. Paliperidone Palmitate-Associated Severe Refractory Tardive Dyskinesia With Tardive Dystonia
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Raman Deep Pattanayak, Sudhir K Khandelwal, Pooja Patnaik Kuppili, Swarndeep Singh, and Ankit Gupta
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Paliperidone Palmitate ,Pediatrics ,medicine.medical_specialty ,business.industry ,Follow up studies ,Tardive dyskinesia ,medicine.disease ,030227 psychiatry ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Refractory ,medicine ,Pharmacology (medical) ,Tardive Dystonia ,Young adult ,business ,030217 neurology & neurosurgery - Published
- 2016
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23. Interdisciplinary recognizing and managing of drug-induced tardive oromandibular dystonia:two case reports
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Tove Henriksen, Heidi Bryde Biernat, Merete Bakke, Eigild Møller, and Torben Dalager
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Drug ,Faculty of Health and Medical Sciences ,Pediatrics ,medicine.medical_specialty ,masticatory muscles ,media_common.quotation_subject ,Case Report ,Case Reports ,Antipsychotic treatment ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,Tongue ,Medicine ,Antipsychotics ,Tardive Dystonia ,botulinum toxin ,Risk factor ,Antipsychotics, botulinum toxin, bruxism, masticatory muscles, tardive dystonia ,media_common ,bruxism ,Dentition ,business.industry ,General Medicine ,Oromandibular dystonia ,medicine.disease ,Botulinum toxin ,medicine.anatomical_structure ,tardive dystonia ,030220 oncology & carcinogenesis ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Key Clinical MessageTardive dystonia is a risk factor in medical antipsychotic treatment. It oftenbegins with repetitive involuntary jaw and tongue movements resulting inimpaired chewing and detrimental effect on the dentition. The orofacial dysfunctionmay go unrecognized in a neurological setting. The diagnosis may bedifficult so we suggest interdisciplinary collaboration. more...
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- 2018
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24. Bupropion-Induced Acute Dystonia with Dose Escalation and Use of Naranjo Nomogram
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Komal Wasif, Nawal Wasif, and Muhammad Wasif Saif
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medicine.medical_specialty ,tardive dyskinesias ,medicine.medical_treatment ,030226 pharmacology & pharmacy ,trismus ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,mental disorders ,medicine ,otorhinolaryngologic diseases ,Internal Medicine ,Antipsychotic ,neck stiffness ,Depression (differential diagnoses) ,Bupropion ,Dystonia ,business.industry ,General Engineering ,temporomandibular joint (tmj) ,medicine.disease ,030227 psychiatry ,Discontinuation ,smoking cessation ,Neurology ,tardive dystonia ,antidepressants ,depression ,behavior and behavior mechanisms ,Smoking cessation ,dystonia ,business ,Adverse drug reaction ,Family/General Practice ,Wellbutrin ,medicine.drug - Abstract
Acute drug-induced dystonia is commonly associated with antipsychotic drugs, antidepressants, antiemetics, and other medications. Bupropion (Wellbutrin and Zyban) is one of the most frequently prescribed antidepressants in the United States and Canada and smoking cessation aid. However, only few reported cases have been published of acute dystonia including dystonia after discontinuation of bupropion and even after a single dose of bupropion. Here, we report another case concerning an acute dystonia resulting from bupropion after dose escalation. To further assess this association, we used the Naranjo nomogram, which is a questionnaire designed for determining the likelihood of whether an adverse drug reaction is actually due to the drug rather than the result of other factors. Our patient's total score was seven, suggesting that our patient had probable adverse drug reaction. In summary, our case is that selected patients may experience dose-related acute dystonia as adverse reactions to bupropion sustained release (SR). Since it is one of the most commonly prescribed antidepressants and smoking cessation aids, clinicians should be aware of the potential dystonia associated with bupropion. more...
- Published
- 2017
25. Globus pallidus deep brain stimulation for adult-onset axial dystonia
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Klaus Mewes, Aasef G. Shaikh, Robert E. Gross, Hyder A. Jinnah, Mahlon R. DeLong, Shirley Triche, Alan Freeman, and Stewart A. Factor
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Adult ,Male ,congenital, hereditary, and neonatal diseases and abnormalities ,Pathology ,medicine.medical_specialty ,Deep brain stimulation ,Movement disorders ,Deep Brain Stimulation ,medicine.medical_treatment ,Globus Pallidus ,Severity of Illness Index ,Article ,Basal ganglia ,otorhinolaryngologic diseases ,Humans ,Medicine ,Tardive Dystonia ,Cervical dystonia ,Aged ,Axial dystonia ,business.industry ,Middle Aged ,medicine.disease ,nervous system diseases ,Treatment Outcome ,surgical procedures, operative ,Globus pallidus ,nervous system ,Neurology ,Dystonic Disorders ,Quality of Life ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,medicine.symptom ,business ,Dystonic disorder - Abstract
Generalized dystonia, both primary and secondary forms, and axial dystonias such as tardive dystonia, and idiopathic cervical dystonia are responsive to globus pallidus interna (GPi) DBS. There is a paucity of investigations probing the impact of DBS on adult-onset axial dystonia. We assessed the efficacy of GPi DBS in four patients with rare adult-onset axial dystonia.Primary outcome measure was improvement in the motor component of the Burke-Fahn-Marsden (BFM) rating scale. Secondary outcome measures were quality of life as determined by the SF-36 questionnaire, time to achieve best possible benefit and DBS parameters that accounted for the best response. In patients with prominent concomitant cervical dystonia we also used the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS).GPi DBS improved BFM scores by 87.63 ± 11.46%. Improvement in total severity scale of TWSTRS was 71.5 ± 12.7%. Quality of life also remarkably improved as evidenced by 109.38 ± 82.97 and 7.05 ± 21.48% percent change in psychometrically-based physical component summary (PCS), and a mental component summary (MCS) score respectively.GPi DBS is a very effective treatment for adult-onset axial dystonia. Considering its refractoriness to medical therapy and significant impact on quality of life DBS should be considered for this disorder. more...
- Published
- 2014
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26. Management of tardive syndromes with clozapine: A case series
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Kaustav Chakraborty, Natasha Kate, Nandita Hazari, Dharmendra Singh, Sandeep Grover, Akhilesh Sharma, Jyoti Gupta, and Sanjay Lahariya
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Response rate (survey) ,Pediatrics ,medicine.medical_specialty ,business.industry ,General Medicine ,Tardive dyskinesia ,medicine.disease ,Psychiatry and Mental health ,medicine ,Tardive Dystonia ,Psychiatry ,business ,General Psychology ,Clozapine ,medicine.drug - Abstract
Tardive syndromes are among the most debilitating side effects associated with use of antipsychotics. In this case series we present 5 cases of drug induced tardive syndromes, who had not responded to many of the other therapeutic measures but responded to clozapine. The response rate with clozapine varied from 50% to 100% and the response was seen by week 3 in most cases. Over the long term follow-up of as long as 6 years the response to clozapine was sustained. In two cases clozapine could be stopped. more...
- Published
- 2014
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27. Quetiapine successfully treating oculogyric crisis induced by antipsychotic drugs.
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Gourzis, Philippos, Polychronopoulos, Panagiotis, Argyriou, Andreas A., Chroni, Elisabeth, and Beratis, Stavroula
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ANTIPSYCHOTIC agents ,CENTRAL nervous system diseases ,MEDICINE ,HEALTH - Abstract
Abstract: We report two patients who developed persistent oculogyric crisis, obsessional thoughts and psychiatric symptoms after prolonged treatment with typical and atypical antipsychotics. Both our patients did not improve after withdrawal of these antipsychotics, but rather after quetiapine was administered. [Copyright &y& Elsevier] more...
- Published
- 2007
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28. GPi-DBS for Tardive Dystonia : A Case Report
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Globus pallidus ,Deep brain stimulation ,business.industry ,medicine.medical_treatment ,medicine ,Surgery ,Neurology (clinical) ,Tardive Dystonia ,business ,Neuroscience - Published
- 2014
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29. Globus pallidus interna deep brain stimulation for tardive dyskinesia: Case report and review of the literature
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Jayne R. Wilkinson, Nicholas B. Galifianakis, Meredith Spindler, and John E. Duda
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Deep brain stimulation ,medicine.medical_treatment ,Globus pallidus ,Clinical Neurology ,Tardive dyskinesia ,Tardive dystonia ,Pallidal stimulation ,Refractory ,medicine ,Humans ,Movement Disorders ,Treatment options ,medicine.disease ,Mood ,Neurology ,Anesthesia ,Neurology (clinical) ,Geriatrics and Gerontology ,Psychology ,Medical therapy ,Globus pallidus interna - Abstract
Tardive dyskinesia (TD) can be a disabling condition and is frequently refractory to medical therapy. Over the past decade there have been many reports of TD patients experiencing significant benefit with deep brain stimulation (DBS) of the globus pallidus interna (GPi). The growing literature on this treatment option for TD consists predominantly of case reports and series. The reported benefit ranges widely, but the majority of cases experienced at least a 50% improvement in symptoms. The anatomical distribution of dyskinesias has not clearly influenced outcome, though fixed postures appear less likely to improve than phasic movements. Onset of benefit can be immediate or take months, and benefit is sustained in most cases, for at least 6 months and up to several years. A wide variety of voltages, frequencies, and pulse widths have demonstrated efficacy. A small number of reports which examined psychiatric symptoms before and after surgery did not find any decline, and in some cases revealed improvement in mood. However, these overall positive results should be interpreted with caution, as the majority of reports lacked blinded assessments, control groups, or standardized therapy parameters. Finally, we present an illustrative case of refractory tardive dyskinesia treated with GPi-DBS with 5 years of follow-up and 4 accompanying video segments. more...
- Published
- 2013
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30. Deep Brain Stimulation for Dystonia: Patient Selection, Surgical Technique, and Programming
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Michele Tagliati and Ron L. Alterman
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Dystonia ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Internal globus pallidus ,Deep brain stimulation ,Younger age ,business.industry ,medicine.medical_treatment ,Stimulation ,medicine.disease ,nervous system diseases ,Surgery ,nervous system ,Anesthesia ,Basal ganglia ,otorhinolaryngologic diseases ,medicine ,Neurology (clinical) ,Tardive Dystonia ,Cervical dystonia ,business - Abstract
Deep brain stimulation (DBS) at the internal globus pallidus (GPi) is currently approved for the treatment of primary generalized and segmental dystonia. Younger age at surgery, shorter disease duration, and absence of fixed skele- tal deformities correlate with a better response to stimulation. Patients with cervical dystonia may also improve. As a group, patients with secondary dystonias respond less well to DBS than do patients with primary dystonia; however, pa- tients with dystonia secondary to anoxic brain injury who have grossly intact basal ganglia anatomy, and patients with tardive dystonia may represent secondary dystonia sub-types for whom pallidal DBS is a viable option. In this submission we review the selection of dystonia patients for DBS surgery and provide details of our approach to surgery and device programming. more...
- Published
- 2011
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31. Missed Diagnosis of Tardive Dystonia in an Adolescent Girl Treated with Risperidone
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Tamara Pringsheim
- Subjects
medicine.medical_specialty ,Risperidone ,business.industry ,media_common.quotation_subject ,Missed diagnosis ,Psychiatry and Mental health ,Pediatrics, Perinatology and Child Health ,medicine ,Pharmacology (medical) ,Girl ,Tardive Dystonia ,Psychiatry ,business ,media_common ,medicine.drug - Published
- 2011
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32. Dramatic improvement of truncal tardive dystonia following globus pallidus pars interna deep brain stimulation
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Neil Mahant, Ainhi D. Ha, Benson Trinh, Samuel D. Kim, Victor S.C. Fung, and Brian Owler
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Adult ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Deep brain stimulation ,Deep Brain Stimulation ,medicine.medical_treatment ,Globus Pallidus ,Physical medicine and rehabilitation ,Physiology (medical) ,otorhinolaryngologic diseases ,Humans ,Medicine ,Tardive Dystonia ,Dystonia ,Movement Disorders ,business.industry ,General Medicine ,medicine.disease ,nervous system diseases ,Globus pallidus ,nervous system ,Neurology ,Female ,Surgery ,Neurology (clinical) ,Presentation (obstetrics) ,business - Abstract
Truncal predominant tardive dystonia is an uncommon presentation of dystonia, and may be associated with significant disability. We report a patient with near-complete resolution of severe, disabling truncal tardive dystonia following globus pallidus pars interna deep brain stimulation. Her unusual clinical presentation highlights the difficulties in diagnosing unusual forms of dystonia, and the therapeutic gains that can be achieved once the diagnosis is recognised. more...
- Published
- 2014
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33. Which patients with dystonia benefit from deep brain stimulation? A metaregression of individual patient outcomes
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Marwan Hariz, Thomas Foltynie, Caroline Andrews, Iciar Aviles-Olmos, National Hospital for Neurology & Neurosurgery, UCL Institute of neurology, UCL Institute of Neurology, Ume University Hospital, and Umea University Hospital more...
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Deep brain stimulation ,DYSTONIA ,Deep Brain Stimulation ,medicine.medical_treatment ,Neurological disorder ,Diagnosis, Differential ,Central nervous system disease ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Quality of life ,otorhinolaryngologic diseases ,medicine ,Humans ,Tardive Dystonia ,030304 developmental biology ,Neurologic Examination ,Dystonia ,0303 health sciences ,business.industry ,STEREOTAXIC SURGERY ,medicine.disease ,nervous system diseases ,3. Good health ,SYSTEMATIC REVIEWS ,Psychiatry and Mental health ,Treatment Outcome ,Dystonic Disorders ,Meta-analysis ,Physical therapy ,Heredodegenerative Disorders, Nervous System ,Regression Analysis ,Surgery ,Neurology (clinical) ,medicine.symptom ,business ,Myoclonus ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
International audience; There is substantial variability in the responsiveness of dystonia patients to deep brain stimulation (DBS), presumably due to the multiple causes of dystonia. This article presents the results of an analysis of the combined published results of individual patient outcomes following DBS for all types of dystonia. From 157 papers reporting clinical outcomes of DBS for dystonia, individual quantitative data were available for 466 patients with all forms of dystonia. The sub-classification of these patients included 344 with primary forms of dystonia, 10 with myoclonus dystonia, 19 with heredo-degenerative dystonias and 93 patients that had DBS for secondary dystonia. Patients with primary forms of dystonia, myoclonus dystonia, subtypes of heredo-degenerative dystonia and tardive dystonia have a greater than 50% mean improvement in dystonia severity following DBS. Among patients with primary generalised dystonia, multiple regression analysis showed that a shorter duration of symptoms (p=0.008), a lower baseline severity score (p=0.024) and DYT-1 positive status (p=0.002) were all independently associated with a significantly higher percentage improvement from surgery. Patients with other forms of heredodegenerative and secondary dystonia have variable responses making prediction of response in future patients difficult. The degree of dystonia response that justifies DBS is a highly subjective issue. Emphasis should be placed on both safety of surgical technique and an in depth evaluation of patients' own perception of their life before and after DBS by using validated quality of life measures, in addition to existing use of objective severity scales. more...
- Published
- 2010
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34. A Biopsychosocial Approach to Improving Quality of Life in Tardive Dystonia
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Sundus H. Alusi, Charlotte Buscombe, and David A. Kahn
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Biopsychosocial model ,Dyskinesia, Drug-Induced ,medicine.medical_specialty ,Movement disorders ,Metoclopramide ,Side effect ,Severity of Illness Index ,Quality of life (healthcare) ,Physical medicine and rehabilitation ,Severity of illness ,otorhinolaryngologic diseases ,Humans ,Medicine ,Tardive Dystonia ,Dystonia ,Movement Disorders ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Quality of Life ,Physical therapy ,Antiemetics ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
Tardive dystonia is a potential side effect of antipsychotic medications and certain other dopamine antagonists. It is characterized by sustained muscle contractions that lead to abnormal postures and movements. It is generally a permanent side effect that has a significant impact on a patient's physical, psychological, and social well-being, decreasing overall quality of life. The authors present the case of a patient with severe tardive dystonia due to metoclopramide that illustrates the profound physical, psychological, and social impact of this condition. It is important for clinicians to be knowledgeable about tardive dystonia so that they can take active steps to prevent its development and have a positive impact on its prognosis when it does develop by recognizing the condition early. Treatment of tardive dystonia should follow a biopsychosocial approach that combines an array of treatment modalities, depending on the individual presentation. Incorporating a quality of life questionnaire specific to dystonia into clinical practice can help clinicians tailor care to the needs of the individual patient. more...
- Published
- 2010
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35. Surgical treatment of dystonia
- Author
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J. K. Krauss
- Subjects
Dystonia ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Deep brain stimulation ,business.industry ,medicine.medical_treatment ,medicine.disease ,Risk profile ,Botulinum toxin ,nervous system diseases ,Physical medicine and rehabilitation ,Neurology ,otorhinolaryngologic diseases ,Physical therapy ,Medicine ,Neurology (clinical) ,Tardive Dystonia ,Cervical dystonia ,Surgical treatment ,business ,Meige Syndrome ,medicine.drug - Abstract
Surgical treatment of dystonia has experienced a tremendous change over the past decade. Whilst selective peripheral denervation is reserved for cervical dystonia refractory to botulinum toxin injections, deep brain stimulation (DBS) of the pallidum has gained a wide scope and presents an elementary column in the treatment of medically refractory patients, nowadays. There is consensus that idiopathic generalized, cervical and segmental dystonia are good indications for DBS, although there is still a paucity of studies providing high-level data according to EBM criteria. Efficacy is maintained on longterm. Several other forms of primary dystonia are still under investigation but it appears that patients with Meige syndrome and myoclonus-dystonia gain also marked benefit. Study of the outcome in secondary dystonia disorders is more complex, in general, but patients with tardive dystonia gain similar improvement than patients with idiopathic dystonia. Overall, the risk profile of pallidal DBS is quite low, and it has been shown to be cognitively safe. The effect of pallidal DBS on non-dystonic extremities has not received much attention, albeit there are hints for a pro-akinetic mechanism. Several questions remain to be solved including optimal programming of stimulation settings, battery drain with high stimulation energies and the elucidation of the mechanisms of DBS in dystonia. more...
- Published
- 2010
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36. Long-Term Benefit Sustained after Bilateral Pallidal Deep Brain Stimulation in Patients with Refractory Tardive Dystonia
- Author
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Edward F. Chang, Lauren E. Schrock, Philip A. Starr, and Jill L. Ostrem
- Subjects
Adult ,Male ,Dyskinesia, Drug-Induced ,Deep brain stimulation ,Deep Brain Stimulation ,medicine.medical_treatment ,Globus Pallidus ,Severity of Illness Index ,Refractory ,Rating scale ,medicine ,Humans ,In patient ,Tardive Dystonia ,Retrospective Studies ,Dystonia ,Mood Disorders ,Middle Aged ,medicine.disease ,Electrodes, Implanted ,nervous system diseases ,Treatment Outcome ,Mood ,Schizophrenia ,Anesthesia ,Dopamine Antagonists ,Female ,Surgery ,Neurology (clinical) ,Psychology - Abstract
Background/Aims: Tardive dystonia (TD) can be a highly disabling, permanent condition related to the use of dopamine-receptor-blocking medications. Our aim was to evaluate the long-term effect of bilateral pallidal deep brain stimulation (DBS) for TD. Methods: Five consecutive patients with disabling TD who underwent stereotactic placement of bilateral globus pallidus internus DBS leads were included. All patients had a history of mood disorder or schizophrenia previously treated with neuroleptic medication, with a mean duration of motor symptoms of 10.2 years. Dystonia severity was measured using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) movement score by a blinded neurologist reviewing pre- and postoperative videotaped examinations. Results: The mean baseline movement BFMDRS score was 49.7 (range 20–88). Overall, we observed a mean reduction of 62% in the BFMDRS movement score within the first year after surgery. Persistent improvement in dystonia (71%) was seen at the last follow-up ranging from 2 to 8 years after surgery. Conclusion: Our experience suggests that pallidal DBS can be an effective therapy with long-term benefits for patients with TD. more...
- Published
- 2010
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37. A case of tardive dystonia associated with long-acting injectable paliperidone palmitate
- Author
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Chia-Hsien Lin, I-Ming Chen, Yi-Ling Chien, Chia-Hao Ma, and Chen-Chung Liu
- Subjects
Adult ,medicine.medical_specialty ,Speech Therapy ,Speech therapy ,03 medical and health sciences ,0302 clinical medicine ,Paliperidone Palmitate ,Medicine ,Humans ,Tardive Dyskinesia ,Pharmacology (medical) ,Tardive Dystonia ,Psychiatry ,Biological Psychiatry ,Clozapine ,Pharmacology ,business.industry ,Dysarthria ,Combined Modality Therapy ,030227 psychiatry ,Psychiatry and Mental health ,Dopamine D2 Receptor Antagonists ,Long acting ,Treatment Outcome ,Neurology ,Delayed-Action Preparations ,Female ,Neurotoxicity Syndromes ,Neurology (clinical) ,Drug Monitoring ,Obsessive Behavior ,business ,Deglutition Disorders ,030217 neurology & neurosurgery ,medicine.drug ,Antipsychotic Agents - Published
- 2016
38. Deep brain stimulation of the internal globus pallidus for refractory tardive dystonia
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Sharon Hassin-Baer, Oren S. Cohen, and Roberto Spiegelmann
- Subjects
Adult ,Male ,Internal globus pallidus ,Deep brain stimulation ,business.industry ,Deep Brain Stimulation ,Mental Disorders ,medicine.medical_treatment ,Symptomatic treatment ,Middle Aged ,Globus Pallidus ,Globus pallidus internus ,Neurology ,Refractory ,Dystonic Disorders ,Pallidal stimulation ,Anesthesia ,medicine ,Humans ,Effective treatment ,Neurology (clinical) ,Tardive Dystonia ,Geriatrics and Gerontology ,business ,Antipsychotic Agents - Abstract
We report a rapid, dramatic and sustained improvement following bilateral pallidal stimulation in two patients affected by intractable generalized tardive dystonia. Both patients had a chronic psychiatric disorder and developed chronic disabling generalized dystonic symptoms persisting despite prolonged withdrawal of neuroleptics and all available symptomatic treatment. The clinical benefit in both patients persisted throughout all the follow up period of 13 and 7 months. The favorable and prolonged response in our two patients suggests that deep brain stimulation may be an effective treatment for medically refractory tardive dystonia. more...
- Published
- 2007
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39. Tiefe Hirnstimulation bei psychischen Erkrankungen - Indikation in Einzelfällen bei Depressionen, Zwangsstörungen, Tourette-Syndrom und tardiven Dyskinesien
- Author
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Irene Neuner and Frank Schneider
- Subjects
Dystonia ,medicine.medical_specialty ,Deep brain stimulation ,business.industry ,medicine.medical_treatment ,Thalamus ,Nucleus accumbens ,medicine.disease ,Tourette syndrome ,nervous system diseases ,Neuropsychology and Physiological Psychology ,Physical medicine and rehabilitation ,nervous system ,Medicine ,In patient ,Tardive Dystonia ,business ,Psychiatry ,Depression (differential diagnoses) - Abstract
The application of deep brain stimulation in neurologic disorders such as dystonia or M. Parkinson raises the question which psychiatric disorder may benefit from deep brain stimulation as well. Until now single case reports or reports summarizing 6 to 10 patients report clinical improvement to a variable degree in patients suffering from depression, obsessive-compulsive disorder, Tourette syndrome or tardive dystonia. The indication for deep brain stimulation was met only after utilised use of medication and psychotherapy. Target regions for depression are a subgenual cingular region, for OCD the anterior part of the internal capsula and the nucleus accumbens. In Tourette syndrome reports mention the subregions of the thalamus , the globus pallidus internus or the nucleus accumbens as target region. In tardive dystonia the globus pallidus internus was stimulated. more...
- Published
- 2007
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40. Local field potential oscillations of the globus pallidus in cervical and tardive dystonia
- Author
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Carlos Trenado, Saskia Elben, Lena Friggemann, Stefan Jun Groiss, Lars Wojtecki, K. Amande M. Pauls, Lars Timmermann, Alfons Schnitzler, Jan Vesper, and Christian J. Hartmann
- Subjects
0301 basic medicine ,Adult ,Male ,Sensory processing ,Intraoperative Neurophysiological Monitoring ,medicine.medical_treatment ,Deep Brain Stimulation ,Alpha (ethology) ,Stimulation ,Sensory system ,Local field potential ,Globus Pallidus ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Tardive Dyskinesia ,Cervical dystonia ,Tardive Dystonia ,Torticollis ,Aged ,business.industry ,Middle Aged ,medicine.disease ,Brain Waves ,030104 developmental biology ,Globus pallidus ,Implantable Neurostimulators ,Neurology ,Female ,Neurology (clinical) ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Background Reports about neural oscillatory activity in the globus pallidus internus (GPi) have targeted general (GD) and cervical dystonia (CD), however to our knowledge they are nonexistent for tardive dystonia (TD). Methods Local field potentials (LFPs) from seven CD and five TD patients were recorded intraoperatively. We compared LFP power in thetadelta, alpha and beta band during rest and sensory palmar stimulation (SPS) in patients with general anesthesia and local/analgo sedation. Results We found prominent LFP power activity in thetadelta for both CD and TD. Unlike TD, a significant difference between rest and SPS was revealed for CD. Conclusions Our data support the presence of LFP oscillatory activity in CD and TD. Thetadelta power modulation in the GPi is suggested as a signature for sensory processing in CD. more...
- Published
- 2015
41. Deep brain stimulation for intractable tardive dystonia: Literature overview
- Author
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Mirosław Ząbek and Michał Sobstyl
- Subjects
medicine.medical_specialty ,Deep brain stimulation ,Movement disorders ,Side effect ,medicine.medical_treatment ,Deep Brain Stimulation ,Tardive dyskinesia ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,medicine ,Humans ,Tardive Dystonia ,Dystonia ,Movement Disorders ,business.industry ,medicine.disease ,nervous system diseases ,Subthalamic nucleus ,Globus pallidus ,030220 oncology & carcinogenesis ,Anesthesia ,Surgery ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Background Tardive dystonia (TD) represents a side effect of prolonged intake of dopamine receptor blocking compounds. TD can be a disabling movement disorder persisting despite available medical treatment. Deep brain stimulation (DBS) has been reported successful in this condition although the number of treated patients with TD is still limited to small clinical studies or case reports. The aim of this study was to present the systematical overview of the existing literature regarding DBS for intractable TD. Methods and results A literature search was carried out in PudMed. Clinical case series or case reports describing the patients with TD after DBS treatment were included in the present overview. Literature search revealed 19 articles reporting 59 individuals operated for TD. GPi was the target in 55 patients, while subthalamic nucleus (STN) was the target in the remaining 4. In most studies the motor part of Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS) was improved by more than 80% when compared to preoperative BFMDRS scores. Conclusions The performed literature analysis indicates that bilateral GPi DBS is an effective treatment for disabling TD. The response of TD to bilateral GPi DBS may be very rapid and occurs within days/weeks after the procedure. The efficacy of bilateral GPi DBS in TD patients is comparable to results achieved in patients with primary generalized dystonia. more...
- Published
- 2015
42. Deep brain stimulation of the internal globus pallidus for disabling haloperidol-induced tardive dystonia. Report of two cases
- Author
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Artur Zaczyński, Mirosław Ząbek, Zbigniew Mossakowski, and Michał Sobstyl
- Subjects
0301 basic medicine ,Adult ,Male ,Deep brain stimulation ,Bipolar Disorder ,Side effect ,medicine.medical_treatment ,Deep Brain Stimulation ,Stimulation ,Tardive dyskinesia ,Globus Pallidus ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Haloperidol ,Humans ,Tardive Dyskinesia ,Tardive Dystonia ,Bipolar disorder ,Depressive Disorder ,business.industry ,Middle Aged ,medicine.disease ,030104 developmental biology ,Globus pallidus ,Treatment Outcome ,Anesthesia ,Surgery ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,medicine.drug ,Antipsychotic Agents - Abstract
Aim Tardive dystonia (TD) represents a side effect of prolonged intake of neuroleptic drugs. TD can be a disabling movement disorder persisting despite available medical treatment. Deep brain stimulation (DBS) has been reported successful in this condition although the number of treated patients with TD is still limited to small clinical studies or case reports. In this study, we present 2 additional cases of patients after bilateral globus pallidus internus (GPi) stimulation. Methods The formal assessment included the Burke–Fahn–Dystonia Rating Scale (BFMDRS). The preoperative and postoperative functional and motor parts of this scale were compared in each patient. The postoperative assessments were done every 6 months. Results Both patients underwent successful bilateral GPi DBS for TD. The postoperative motor score improved by 78% at 24 months in patient 1 and 69% at 12 months in patient 2. There were no surgical or hardware-related complications over follow-up period. Conclusion Our experience indicates that bilateral GPi DBS can be an effective treatment for disabling TD. The response of TD to bilateral GPi DBS is very rapid and occurs within days after the procedure. more...
- Published
- 2015
43. Deep brain stimulation for tardive disorders
- Author
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Kelvin L. Chou and Bernardo Rodrigues
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Microelectrode recording ,Deep brain stimulation ,business.industry ,medicine.medical_treatment ,Thalamus ,medicine ,Pallidotomy ,Tardive Dystonia ,MEDICATION-INDUCED MOVEMENT DISORDERS ,Tardive dyskinesia ,medicine.disease ,business ,Neuroscience - Published
- 2015
- Full Text
- View/download PDF
44. Deep brain stimulation in the treatment of tardive dystonia
- Author
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Zhong-cheng Wang, Jianguo Zhang, and Kai Zhang
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Dystonia ,Subthalamic nucleus ,Globus pallidus ,Deep brain stimulation ,business.industry ,medicine.medical_treatment ,Medicine ,General Medicine ,Tardive Dystonia ,Ventral Thalamic Nucleus ,business ,medicine.disease ,Neuroscience - Published
- 2006
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45. Excoriation disorder as a risk factor for deep brain stimulation hardware removal
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Daniela Calandrella, Michele Rizzi, Francesca Ferrè, and Luigi Romito
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Dystonia ,Deep brain stimulation ,business.industry ,medicine.medical_treatment ,Excoriation ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Neurology ,Anesthesia ,medicine ,Pallidotomy ,030212 general & internal medicine ,Neurology (clinical) ,Bipolar disorder ,Tardive Dystonia ,Risk factor ,business ,030217 neurology & neurosurgery - Published
- 2017
- Full Text
- View/download PDF
46. Fatal Status Dystonicus in Tardive Dystonia Due to Depletion of Deep Brain Stimulation's Pulse Generator
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Shahnaz Miri, Mohammad Rohani, Renato P. Munhoz, Mansour Parvaresh, and Gholam Ali Shahidi
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0301 basic medicine ,medicine.medical_specialty ,Deep brain stimulation ,business.industry ,General Neuroscience ,Pulse generator ,medicine.medical_treatment ,Biophysics ,medicine.disease ,Status dystonicus ,lcsh:RC321-571 ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Physical medicine and rehabilitation ,medicine ,Neurology (clinical) ,Tardive Dystonia ,business ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,030217 neurology & neurosurgery - Published
- 2017
47. Mouvements anormaux d’origine médicamenteuse : les syndromes tardifs
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Hélène Peyrière, Véronique Pinzani, Dominique Hillaire-Buys, and Jean-Pierre Blayac
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Dystonia ,Involuntary movement ,medicine.medical_specialty ,Movement disorders ,business.industry ,Neurological disorder ,medicine.disease ,Tardive dyskinesia ,Akathisia ,Dyskinesia ,medicine ,Pharmacology (medical) ,Tardive Dystonia ,medicine.symptom ,business ,Psychiatry - Abstract
Persistent drug-induced movement disorders (tardive syndromes) remain an important clinical problem and consist of a variety of involuntary movements appearing in a patient exposed to a dopamine-blocking agent. The current state of knowledge on this topic is summarised in this article. Clinical aspects (tardive dyskinesia, tardive dystonia and other forms), prevalence, risk factors, prevention and management are discussed. more...
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- 2004
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48. Tardive dystonia with olanzapine: A rare case report
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Rajinder Kumar, Poonam Bharti, and Gurvinder Pal Singh
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Drug ,Olanzapine ,medicine.medical_specialty ,Pediatrics ,Side effect ,medicine.drug_class ,media_common.quotation_subject ,olanzapine ,RC435-571 ,Atypical antipsychotic ,Alcohol dependence syndrome ,Case Report ,Rare case ,medicine ,Tardive Dystonia ,Psychiatry ,media_common ,business.industry ,Clinical Practice ,Clinical Psychology ,Psychiatry and Mental health ,tardive dystonia ,business ,medicine.drug - Abstract
Olanzapine is an atypical antipsychotic drug which is available in oral and injectable forms that is used for treatment of various psychiatric disorders. We report a rare case of tardive dystonia after receiving single dose of olanzapine (10 mg) in parental form. Clinicians should be very vigilant regarding this rare side effect with use of olanzapine in clinical practice. more...
- Published
- 2012
49. A case report of Olanzapine induced Tardive Dystonia presenting along with Catatonia
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Jayati Simlai, Neha Singh, Sanjay Kumar Munda, and Christoday Rj Khess
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Olanzapine ,medicine.medical_specialty ,Pediatrics ,Catatonia ,business.industry ,medicine.disease ,Prolonged exposure ,medicine ,Tardive Dystonia ,Involuntary muscle contractions ,Psychiatry ,business ,Clozapine ,medicine.drug - Abstract
Tardive dystonia (TD) is a movement disorder dominated by involuntary muscle contractions associated with prolonged exposure to neuroleptics. We are reporting a unique case of Olanzapine induced TD which presented along with catatonia. Both the disorders showed significant improvement with Clozapine. We recommend use of Clozapine for the management of cases of TD with catatonia. more...
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- 2015
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50. Tardive syndrome and Parkinson’s disease responsive to concomitant tetrabenazine and levodopa therapy
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Oriol Franch and Monica M. Kurtis
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medicine.medical_specialty ,Levodopa ,Parkinson's disease ,business.industry ,Parkinsonism ,Tetrabenazine ,Levodopa therapy ,medicine.disease ,Gastroenterology ,Neurology ,Internal medicine ,Concomitant ,Medicine ,Neurology (clinical) ,Tardive Dystonia ,Geriatrics and Gerontology ,business ,medicine.drug - Published
- 2011
- Full Text
- View/download PDF
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