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Abstract Introduction Neural stem cells from the subventricular zone (SVZ) neurogenic niche provide neurons that integrate in the olfactory bulb circuitry. However, in response to cortical injuries, the neurogenic activity of the SVZ is significantly altered, leading to increased number of neuroblasts with a modified migration pattern that leads cells towards the site of injury. Despite the increased neurogenesis and migration, many newly generated neurons fail to survive or functionally integrate into the cortical circuitry. Providing the injured area with the adequate signaling molecules may improve both migration and functional integration of newly generated neurons. Methods In here, we have studied the effect of a diterpene with the capacity to induce neuregulin release at promoting neurogenesis in a murine model of cortical brain injury. Using green fluorescent protein expressing vectors we have labeled SVZ cells and have studied the migration of newly generated neuroblasts toward the injury in response the treatment. In addition, using electrophysiological recordings we have studied the differentiation of these neuroblasts into mature neurons and their functional integration into the cortical circuitry. We have studied their electrical properties, their morphology and cortical location. Results We have found that EOF2 treatment of adult mice with mechanical cortical injuries facilitates the delivery of neuroblasts into these injuries. The newly generated neurons develop features of fully functional neurons. Our results show that the newly generated neurons receive electrical inputs, fire action potentials, and undergo complete differentiation into neurons recapitulating the stages that distinguish ontogenic differentiation. These neurons develop features representative of neurons belonging the cortical layer in which they are situated. We have also studied that EOF2 facilitates neuregulin release in SVZ cells, a signaling factor that promotes neuronal differentiation. Neuregulin is expressed in microglial cells that reach the injury in response to the damage and its release is increased by EOF2 treatment. Conclusion Promoting neuregulin release via diterpene treatment facilitates migration of SVZ-derived neuroblasts to cortical injuries stimulating their differentiation into mature functional neurons, which receive electrical inputs and develop features of cortical neurons. These findings highlight the role of diterpenoids as a potential therapy to repair cortical brain injuries.

El docente de las carreras de las ciencias médicas debe tener identificadas las áreas lingüísticas o idiomáticas para transmitir correctamente el mensaje (escuchar, hablar, leer e interpretar), pero esta competencia sociocultural estratégica influye directamente en la relación con los pacientes y con los alumnos, teniendo en cuenta el papel protagónico de éstos para la educación en el trabajo que se desarrolla en las consultas médicas. No sólo la expresión oral y escrita forman parte de la comunicación, sino las relaciones afectivas valorativas como funciones de ésta, que deben estar presentes en la relación médico-paciente, profesor-estudiante, así como la influencia que ejerce el tutor en la formación de las habilidades comunicativas en los propios estudiantes.

Los profesionales de la información y la documentación se ubican en una sociedad donde el elemento básico para el desarrollo del individuo y de la propia sociedad es la Información: una sociedad caracterizada por el desarrollo de las nuevas tecnologías de la información y la comunicación, un crecimiento abrumador de la información científico-técnica, el surgimiento de nuevos soportes, una tendencia a trabajar en entornos virtuales y al desarrollo de redes.