1. Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet
- Author
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Salka Elbøl Rasmussen, Lea Bredsdorff, Jóhanna Haraldsdóttir, Kirstine Suszkiewicz Krogholm, and Pia Knuthsen
- Subjects
Adult ,Male ,Naringenin ,Flavonoid ,Cmax ,Biological Availability ,Medicine (miscellaneous) ,Young Adult ,chemistry.chemical_compound ,Humans ,heterocyclic compounds ,Food science ,chemistry.chemical_classification ,Nutrition and Dietetics ,Hesperidin ,Hesperidina ,Area under the curve ,Hesperetin ,food and beverages ,Diet ,Bioavailability ,chemistry ,Biochemistry ,Area Under Curve ,Flavanones ,Quercetin - Abstract
The bioavailability and urinary excretion of three dietary flavonoids, quercetin, hesperetin and naringenin, were investigated. Ten healthy men were asked to consume a 'juice mix' containing equal amounts of the three flavonoids, and their urine and plasma samples were collected. The resulting mean plasma area under the curve (AUC)(0-48 h) and C(max) values for quercetin and hesperetin were similar, whereas the AUC(0-48 h) of naringenin and, thus, the relative bioavailability were higher after consumption of the same dose. The study consolidates a significantly lower urinary excretion of quercetin (1.5+/-1%) compared with hesperetin (14.2+/-9.1%) and naringenin (22.6+/-11.5%) and shows that this is not due to a lower bioavailability of quercetin, but rather reflects different clearance mechanisms.
- Published
- 2010