1. Microbiology of bacterial bloodstream infections among patients with solid tumors and hematologic malignancies in Africa: A scoping review
- Author
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Gulleen, Elizabeth, Lubwama, Margaret, Thielen, Beth, Bwanga, Freddie, Kateete, David, Orem, Jackson, Liu, Catherine, and Phipps, Warren
- Subjects
Oncology ,Bacteria ,Bacterial Infections and Mycoses ,Neoplasms ,Organisms ,Medicine and Health Sciences ,Medical Specialties ,Infectious Disease ,Diseases - Abstract
Bacterial bloodstream infections (BSIs) are a major cause of morbidity and mortality among patients receiving cancer treatment. Current international/consensus guidelines for the antibiotic management of bacterial BSIs in patients with cancer were developed in settings with low prevalence of multi-drug resistant bacteria and where HIV, tuberculosis, and malaria are non-endemic. In this scoping review, we will summarize the current state of evidence regarding the bacterial causes of BSIs among patients with cancer who are living in Africa. We will also describe the antibiotic resistance patterns among Gram-negative and Gram-positive bacteria isolated from the blood of patients with cancer. The objective of this review is to summarize the current literature regarding the bacterial causes of BSIs among patients with cancer who live in North Africa or sub-Saharan Africa. This information can be used to adapt antibiotic management guidelines developed in high-resource settings to best address the microbiologic causes of infections among patients with cancer in Africa. Our primary review question is: - What are the most common bacterial causes of BSIs among patients with solid tumors and hematologic malignancies living in Africa. Our secondary review questions are: - How do the bacterial causes of BSIs differ for adult and pediatric patients with solid tumors or hematologic malignancies? - What are the most frequently described antibiotic resistance patterns among Gram-positive bacteria isolated from blood cultures of patients with cancer? - What are the most frequently described antibiotic resistance patterns among Gram-negative bacteria isolated from blood cultures of patients with cancer? - What are the currently identified risk -factors associated with developing bacterial BSIs among adult and pediatric patients with solid tumor or hematologic malignancies living in Africa? - What are the currently described mortality rates for patients who develop bacterial BSIs?
- Published
- 2022
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