1. EEG microstates are a candidate endophenotype for schizophrenia
- Author
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Eka Chkonia, Michael H. Herzog, Christine Mohr, Maya Roinishvili, Patrícia Figueiredo, Andreas Brand, Ophélie Favrod, and Janir Nuno da Cruz
- Subjects
Male ,Psychosis ,medicine.medical_specialty ,Electroencephalography - EEG ,Endophenotypes ,Science ,General Physics and Astronomy ,Electroencephalography ,Audiology ,General Biochemistry, Genetics and Molecular Biology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Ministate ,mental disorders ,medicine ,Humans ,In patient ,lcsh:Science ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,General Chemistry ,medicine.disease ,030227 psychiatry ,EEG microstates ,medicine.anatomical_structure ,Psychotic Disorders ,Schizophrenia ,Endophenotype ,Scalp ,Female ,lcsh:Q ,business ,030217 neurology & neurosurgery - Abstract
Electroencephalogram microstates are recurrent scalp potential configurations that remain stable for around 90 ms. The dynamics of two of the four canonical classes of microstates, commonly labeled as C and D, have been suggested as a potential endophenotype for schizophrenia. For endophenotypes, unaffected relatives of patients must show abnormalities compared to controls. Here, we examined microstate dynamics in resting-state recordings of unaffected siblings of patients with schizophrenia, patients with schizophrenia, healthy controls, and patients with first episodes of psychosis (FEP). Patients with schizophrenia and their siblings showed increased presence of microstate class C and decreased presence of microstate class D compared to controls. No difference was found between FEP and chronic patients. Our findings suggest that the dynamics of microstate classes C and D are a candidate endophenotype for schizophrenia., EEG microstate abnormalities have been reported in patients with schizophrenia. Here the authors demonstrate that patients and their siblings show similar microstate abnormalities compared to healthy controls.
- Published
- 2020