Search

Your search keyword '"Ayala, A."' showing total 4,667 results
Start Over Author "Ayala, A." Topic medicine.disease
4,667 results on '"Ayala, A."'

1. Echocardiographic markers of cardiac amyloidosis in patients with heart failure and left ventricular hypertrophy

Author

Anyuli Gracia Gutiérrez, Raquel Pérez-Palacios, Ana Roteta Unceta-Barrenechea, Jorge Melero Polo, Pablo Revilla Martí, Esperanza Bueno Juana, Alejandro Andrés Gracia, Miguel Ángel Aibar Arregui, and Saida Atienza Ayala

Subjects
medicine.medical_specialty, business.industry, Retrospective cohort study, General Medicine, Left ventricular hypertrophy, medicine.disease, Right atrial, medicine.anatomical_structure, Cardiac amyloidosis, Heart failure, Internal medicine, cardiovascular system, Cardiology, Medicine, In patient, Decompensation, cardiovascular diseases, Interventricular septum, Cardiology and Cardiovascular Medicine, business
Abstract

Background: Cardiac amyloidosis (CA), following a non-invasive diagnosis, constitutes an increasingly prevalent heart failure (HF) etiology. This study aims to determine which echocardiography findings help to diagnose cardiac amyloidosis in patients with left ventricular hypertrophy (LVH) admitted for decompensated HF. M ethods: The present study is a retrospective observational study on a cohort of 85 LVH patients admitted for HF decompensation, in which 99m Tc-DPD scanning was performed to rule out transthyretin CA. The echocardiographic findings obtained were compared between CA and non-CA groups. Results: From a total number of 85 patients, 49 (57.6%) met the CA criteria and 36 (42.3%) were ruled out for the disease. Interventricular septum thickness (16 ± 3 mm vs. 14 ± 3 mm), left ventricular posterior wall thickness (14 ± 3 mm vs. 11 ± 2 mm), left ventricular mass (259 ± 76 g vs. 224 ± 53 g), left ventricular telediastolic diameter (48 ± 7 mm vs. 53 ± 6 mm), left ventricular telediastolic indexed volume (51 ± 18 cm 3 /m 2 vs. 59 ± 16 cm 3 /m 2 ), tricuspid annular plane systolic excursion (16 ± 5 mm vs. 20 ± 4 mm), right atrial area (27.4 ± 8.4 cm 2 vs. 22.2 ± 5.7 cm 2 ) and strain relative apical sparing (2.2 ± 0.9 vs. 1.03 ± 0.4; p = 0.04) were significantly associated with the diagnosis of CA. Conclusions: In patients with LVH admitted for HF decompensation, there are several echocardiographic features (LVH, reduced left ventricular cavity size, strain relative apical sparing, right atrial dilation, and altered right ventricular function) that are associated with the diagnosis of cardiac amyloidosis.

Published
2023

2. Long-term chronic joint pain after sleeve gastrectomy and its influence on clinical and psychological outcomes

Author

Luisa Ayala, Pilar Sanchis, Lluís Masmiquel, Joana Nicolau, Keyla Dotres, Andrés Cifuentes, María Isabel Tamayo, Salvador Pascual, and Irene Rodríguez

Subjects
medicine.medical_specialty, Sleeve gastrectomy, Nutrition and Dietetics, Chronic joint pain, business.industry, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Gastric Bypass, medicine.disease, Arthralgia, Comorbidity, Obesity, Morbid, Cross-Sectional Studies, Endocrinology, Gastrectomy, Internal medicine, Metabolic effects, Weight Loss, medicine, Humans, Functional status, In patient, business
Abstract

Bariatric surgery (BS) is effective in improving chronic joint pain (CJP). However, the long-term effects on this comorbidity are poorly understood.To determine the prevalence of CJP in a sample of patients who had undergone BS with a minimum follow-up of 18 months. To determine whether or not there was any relationship between CJP and clinical or psychological outcomes after BS.Cross-sectional study. The Lattinen index (LI) was used to evaluate CJP, using the cut-off point of 10 to define significant CJP (SCJP).Of the 110 subjects assessed, 31.2% (35/110) had SCJP. The patients with SCJP were older (57.4±13 vs 47.8±11.6 years; p0.0001) and more time had elapsed since their BS (105.6±54.3 vs 78.5±39 months; p=0.023). The last BMI was higher in subjects with SCJP (35±5 vs 33.3±6.9kg/mSCJP is highly prevalent in patients who have had BS once they reach the weight plateau phase. There is an association between having SCJP and worse psychological and functional status, with potential detrimental metabolic effects.

Published
2022

3. Determinants of Discordance Between Criteria for Inactive Disease and Low Disease Activity in Juvenile Idiopathic Arthritis

Author

Gabriella Giancane, Chiara Campone, Maria Francesca Gicchino, Alessandra Alongi, Cecilia Bava, Silvia Rosina, Yaryna Boyko, Neil Martin, Yasser El Miedany, Miroslav Harjacek, Soad Hashad, Maka Ioseliani, Ruben Burgos-Vargas, Rik Joos, Christiaan Scott, Mejbri Manel, Zoilo Morel Ayala, Maria Ekelund, Safiya Al-Abrawi, Maya-Feriel Aiche, Ximena Norambuena, Jose Antonio Melo-Gomes, Nicolino Ruperto, Alessandro Consolaro, Angelo Ravelli, Paediatric Rheumatology International Trials Organisation, Giancane, Gabriella, Campone, Chiara, Gicchino, MARIA FRANCESCA, Alongi, Alessandra, Bava, Cecilia, Rosina, Silvia, Boyko, Yaryna, Martin, Neil, El Miedany, Yasser, Harjacek, Miroslav, Hashad, Soad, Ioseliani, Maka, Burgos-Vargas, Ruben, Joos, Rik, Scott, Christiaan, Manel, Mejbri, Morel Ayala, Zoilo, Ekelund, Maria, Al-Abrawi, Safiya, Aiche, Maya-Feriel, Norambuena, Ximena, Antonio Melo-Gomes, Jose, Ruperto, Nicolino, Consolaro, Alessandro, Ravelli, Angelo, and Rheumatology International Trials Organisation, Paediatric

Subjects
Male, medicine.medical_specialty, Oligoarthritis, Absolute number, business.industry, Concordance, Patient Acuity, Infant, Arthritis, medicine.disease, Severity of Illness Index, Arthritis, Juvenile, Disease activity, Cross-Sectional Studies, Rheumatology, Child, Preschool, Internal medicine, medicine, Humans, Juvenile, Female, Polyarthritis, Child, Inactive disease, business
Abstract

Objective To assess concordance among criteria for inactive disease (ID) and low disease activity (LDA) in juvenile idiopathic arthritis (JIA) and to seek factors driving discordance. Methods The frequency of fulfillment of existing criteria was evaluated in information on 10,186 patients extracted from 3 cross-sectional data sets. Patients were divided up according to the functional phenotypes of oligoarthritis and polyarthritis. Concordance between criteria was examined using weighted Venn diagrams. The role of each individual component in explaining discordance between criteria was assessed by calculating the absolute number and percentage of instances in which the component was responsible for discrepancy between definitions. Results Criteria for ID were met by 28.6–41.1% of patients with oligoarthritis and by 24.0–33.4% of patients with polyarthritis. Criteria for LDA were met by 44.8–62.4% of patients with oligoarthritis and by 44.6–50.4% of patients with polyarthritis. There was a 57.9–62.3% overlap between criteria for ID and a 67.9–85% overlap between criteria for LDA. Parent and physician global assessments and acute-phase reactants were responsible for the majority of instances of discordance among criteria for ID (8.7–15.5%, 10.0–12.3%, and 10.8–17.3%, respectively). Conclusion We found fair concordance between criteria for ID and LDA in JIA, with the main drivers of discordance for ID being physician and parent global assessments and acute-phase reactants. This observation highlights the need for further studies aimed to evaluate the impact of subjective physician and parent perception of disease remission and of laboratory measures of inflammatory activity on the definition of ID.

Published
2021

4. Tomographic behavior of pneumonia caused by SARS-CoV-2

Author

Eva A. Izquierdo-Echávarri, Francisco J. Ayala-Ochoa, Luis A. Concha-Rebollar, Luis F. Alva-López, and Vito S. Hernández-Melchor

Subjects
Adult, Male, medicine.medical_specialty, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Ground-glass opacity, Young Adult, medicine, Medical imaging, Humans, Chest tomography, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Respiratory disease, Transverse axis, COVID-19, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Pneumonia, Female, Radiology, medicine.symptom, Tomography, X-Ray Computed, business
Abstract

From the first report of the respiratory disease caused by SARS-Cov-2 towards the end of 2019, in Wuhan, China, to June 8, 2020, 6,931,000 people had been affected in the world, and 113,619 in Mexico, where there is a lack of literature describing the tomographic behavior of this disease throughout its evolution and its correlation with patient clinical data.To identify, describe and classify the manifestations detected on chest computed tomography images of patients with pneumonia caused by SARS-CoV-2.Hospitalized patients with RT-PCR-confirmed SARS-CoV-2 infection and who underwent a plain chest tomography were included.The most common tomographic patterns were ground glass opacity, consolidation, cobblestone pattern and mixed pattern, with peripheral and subpleural distribution and bilateral involvement in up to 95 %. Subpleural bands that distorted the architecture were identified in up to 62 % of patients, with an average of seven days of evolution. The most common extrapulmonary finding was an increase in pulmonary artery transverse axis.Knowing the behavior of this type of pneumonia allows becoming familiarized with the characteristic tomographic patterns, in order to aid timely detection and treatment.Desde el primer reporte de la enfermedad respiratoria causada por SARS-Cov-2 a finales de 2019, en Wuhan, China, hasta el 8 de junio de 2020, habían sido afectadas 6 931 000 personas en el mundo y 113 619 en México, donde se carece de informes que describan el comportamiento tomográfico de esta enfermedad a lo largo de su evolución y su correlación con los datos clínicos del paciente.Identificar, describir y clasificar las manifestaciones en las imágenes de tomografía de tórax de pacientes con neumonía causada por SARS-CoV-2.Se incluyeron pacientes hospitalizados con infección por SARS-CoV-2 confirmada mediante PCR-TR y en quienes se realizó tomografía simple de tórax.Los patrones tomográficos más comunes fueron opacidad de vidrio despulido, consolidación, empedrado y patrón mixto, con distribución periférica, subpleural y afectación bilateral hasta en 95 %. Se identificaron bandas subpleurales que distorsionaban la arquitectura hasta en 62 % de los pacientes, con un promedio de siete días de evolución. El aumento del eje transverso de la arteria pulmonar constituyó el hallazgo extrapulmonar más frecuente.Conocer el comportamiento de este tipo de neumonía permite la familiarización con los patrones tomográficos característicos, con el fin de coadyuvar a la detección y tratamiento oportunos.

Published
2023

5. Role of sleep disorders during gestation on fetal programming for the development of obesity and chronic-degenerative diseases

Author

Erika Estrada-Ramírez, Claudia González-Méndez, Montserrat Melgarejo-Gutiérrez, Arely Vergara-Castañeda, María del Rosario Ayala-Moreno, and Rafael Velázquez-Martínez

Subjects
Pediatrics, medicine.medical_specialty, business.industry, medicine, Gestation, General Medicine, Fetal programming, medicine.disease, business, Obesity, Sleep in non-human animals
Published
2023

7. Systematic review and meta-analysis of aortic valve-sparing surgery versus replacement surgery in ascending aortic aneurysms and dissection in patients with Marfan syndrome and other genetic connective tissue disorders

Author

Eric Ochoa-Hein, María Elena Soto, Micaela Ayala-Picazo, Javier E Anaya-Ayala, and Solange Gabriela Koretzky

Subjects
Pulmonary and Respiratory Medicine, Aortic dissection, Marfan syndrome, Aortic valve, medicine.medical_specialty, business.industry, medicine.disease, Surgery, Aortic aneurysm, Dissection, medicine.anatomical_structure, Aneurysm, Meta-analysis, medicine, Endocarditis, Original Article, business
Abstract

Background Aortic aneurysm and dissection are important causes of morbimortality in patients with Marfan syndrome (MFS) and other connective tissue diseases that affect the cardiovascular tissues. Timely intervention through different surgical techniques improves the prognosis. Both sparing and replacement-type interventions of the aortic valve are used, but selection depends on the condition of the patient at the time of diagnosis, the patient's emergency condition, surgeon preference and hospital resources. Previous meta-analyses have suggested an advantage with the use of sparing-type interventions, but this finding must be updated and extended to patients with other connective tissue disorders. The objetive of this study is to evaluate the outcomes of valve-sparing root replacement versus aortic root replacement procedures in patients with MFS and similar connective tissue diseases that present with aortic aneurysm or dissection. Methods A systematic review of cohort studies that evaluated sparing-type (preserving, remodeling, reimplantation, Yacoub, David or Florida Sleeve) or replacement-type (repair, Bentall, Button-Bentall, composite valve graft or Cabrol) procedures in patients with Marfan, Loeys-Dietz, Beals-Hecht or Ehlers-Danlos syndromes was done. Studies were retrieved from the SCOPUS, MEDLINE, CINAHL, EMBASE and LILACS electronic databases up to January 2020 without language restrictions. Only studies that directly compared sparing- versus replacement-type procedures were included in the meta-analysis. Results A total of 33 studies (n=1,807 subjects) reported sparing-type surgical interventions and 26 studies (n=2,218 subjects) reported replacement-type surgical interventions. Pooled rates of endocarditis, thromboembolism and aneurysm were higher in replacement-type surgical intervention studies. Sixteen studies were included in the meta-analysis. Sparing-type interventions were associated with a reduced risk of endocarditis (RR =0.13, 95% CI: 0.03-0.61); however, replacement-type interventions favored freedom from valve reoperation (RR =2.39, 95% CI: 1.24-4.60). All studies were at low risk of bias. Conclusions The choice of the best surgical technique is dependent on the type of disease (MFS or other connective tissue diseases) as well as the accompanying aortic and cardiovascular damage, since these key factors are heterogeneous. Although the results of this meta-analysis tend to show some advantages for one type of surgical intervention over the other and viceversa, the surgeon can only make the best decision during the surgical act.

Published
2021

8. European Surveillance System on Contact Allergies (ESSCA)

Author

Loman, Laura, Uter, Wolfgang, Armario-Hita, José C., Ayala, Fabio, Balato, Anna, Ballmer-Weber, Barbara K., Bauer, Andrea, Bircher, Andreas J., Buhl, Timo, Czarnecka-Operacz, Magdalena, Dickel, Heinrich, Fuchs, Thomas, Giménez Arnau, Ana, John, Swen M., Kränke, Birger, Kręcisz, Beata, Mahler, Vera, Rustemeyer, Thomas, Sadowska-Przytocka, Anna, Sánchez-Pérez, Javier, Scherer Hofmeier, Kathrin, Schliemann, Sibylle, Simon, Dagmar, Spiewak, Radoslaw, Spring, Philip, Valiukevičienė, Skaidra, Wagner, Nicola, Weisshaar, Elke, Pesonen, Maria, Schuttelaar, Marie L. A., Aberer, Werner, Beiteke, Ulrike, Frosch, Peter, Werfel, Thomas, Elsner, Peter, Becker, Detlef, Sliuziaviciene, Gondinga, Kiec-Swierczynska, Marta, Silvestre, Juan F., Ruiz, Inmaculada, Mercader, Pedro, Fernández-Redondo, Virginia, García-Gavín, Juan, Grabbe, J. rgen, Navarini, Alexander, Loman, Laura, Uter, Wolfgang, Armario-Hita, José C, Ayala, Fabio, Balato, Anna, Ballmer-Weber, Barbara K, Bauer, Andrea, Bircher, Andreas J, Buhl, Timo, Czarnecka-Operacz, Magdalena, Dickel, Heinrich, Fuchs, Thoma, Giménez Arnau, Ana, John, Swen M, Kränke, Birger, Kręcisz, Beata, Mahler, Vera, Rustemeyer, Thoma, Sadowska-Przytocka, Anna, Sánchez-Pérez, Javier, Scherer Hofmeier, Kathrin, Schliemann, Sibylle, Simon, Dagmar, Spiewak, Radoslaw, Spring, Philip, Valiukevičienė, Skaidra, Wagner, Nicola, Weisshaar, Elke, Pesonen, Maria, Schuttelaar, Marie L A, Medicina, Dermatology, and Public Health Research (PHR)

Subjects
medicine.medical_specialty, Allergy, IMPACT, Population, 610 Medicine & health, Dermatology, Disease, occupational contact dermatiti, sensitization, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, irritant contact dermatitis, Epidemiology, medicine, Immunology and Allergy, ATOPIC-DERMATITIS, Clinical significance, 030212 general & internal medicine, NETWORK, education, RRID, Allergic contact dermatitis, patch testing, education.field_of_study, patch test, Kontaktallergie, allergic contact dermatitis, body site, contact allergy, business.industry, SCR_001905 [RRID], BASE-LINE SERIES, Original Articles, medicine.disease, RRID:SCR_001905, 3. Good health, occupational contact dermatitis, irritant contact dermatiti, DISEASES, Irritant contact dermatitis, Original Article, epidemiology, eczema, SCR_001905, business, Contact dermatitis, SKIN
Abstract

Background Irritant contact dermatitis (ICD) is caused by the acute locally toxic effect of a strong irritant, or the cumulative exposure to various weaker physical and/or chemical irritants. Objectives To describe characteristics of patients with ICD in the population patch tested in the European Surveillance System on Contact Allergies (ESSCA; www.essca-dc.org) database. Methods Data collected by the ESSCA in consecutively patch tested patients from January 2009 to December 2018 were analyzed. Results Of the 68 072 patients, 8702 patients were diagnosed with ICD (without concomitant allergic contact dermatitis [ACD]). Hand and face were the most reported anatomical sites, and 45.7% of the ICD was occupational ICD (OICD). The highest proportions of OICD were found in metal turners, bakers, pastry-cooks and confectionery makers. Among patients diagnosed with ICD, 45% were found sensitized with no relevance for the current disease. Conclusions The hands were mainly involved in OICD also in the subgroup of contact dermatitis patients, in whom relevant contact sensitization had been ruled out, emphasizing the need for limiting irritant exposures. However, in difficult to treat contact dermatitis, unrecognized contact allergy, or unrecognized clinical relevance of identified allergies owing to incomplete or wrong product ingredient information must always be considered. This article is protected by copyright. All rights reserved.

Published
2021

9. La hidroxicloroquina como fármaco fundamental en dermatología y su papel controvertido en la COVID-19

Author

J. Ibaceta-Ayala, Daniel Morgado-Carrasco, and J. Piquero-Casals

Subjects
Drug, medicine.medical_specialty, Systemic lupus erythematosus, business.industry, media_common.quotation_subject, Hydroxychloroquine, General Medicine, medicine.disease, Dermatology, Immune system, medicine, Porphyria cutanea tarda, Sarcoidosis, skin and connective tissue diseases, business, Adverse effect, Granuloma annulare, media_common, medicine.drug
Abstract

Hydroxychloroquine is an antimalarial drug with immunomodulatory, anti-inflammatory, antibacterial, and antiviral properties. It has a good safety profile, can be used in children and in pregnant and breastfeeding women, and does not suppress the immune system. Regular screening for retinopathy, one of the drug's most feared adverse effects, is necessary. Hydroxychloroquine is a widely used, essential drug in dermatology. Clinical response rates are good in lupus erythematous, where it is a first-line therapy, as well in numerous autoimmune/inflammatory diseases, including lichen planus, polymorphic light eruption, porphyria cutanea tarda, granuloma annulare, and sarcoidosis. In 2020, it was widely prescribed both to prevent and to treat COVID-19 caused by SARS-CoV-2. Its increased use led to serious supply shortages and in some cases stocks were entirely depleted. Recent meta-analyses have concluded that hydroxychloroquine is ineffective against COVID-19 and have advised against its use.

Published
2022

10. Impact of Cell of Origin on Outcomes After Autologous Hematopoietic Cell Transplant in Diffuse Large B-Cell Lymphoma

Author

Mohamed A. Kharfan-Dabaja, Luis F. Porrata, Jose Villasboas Bisneto, Hemant S. Murthy, Ivana N. Micallef, Ernesto Ayala, Muhamad Alhaj Moustafa, Allison C. Rosenthal, Zhuo Li, Han W. Tun, Patrick B. Johnston, Yennifer Gil Castano, Stephen M. Ansell, Madiha Iqbal, David J. Inwards, James M. Foran, Manuel Beltran, Jonas Paludo, Vivek Roy, and Craig B. Reeder

Subjects
Cancer Research, medicine.medical_specialty, Multivariate analysis, Cell of origin, Gastroenterology, Refractory, immune system diseases, Median follow-up, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, In Situ Hybridization, Fluorescence, medicine.diagnostic_test, business.industry, Incidence (epidemiology), Hematopoietic Stem Cell Transplantation, Germinal center, Hematology, Prognosis, medicine.disease, Oncology, Lymphoma, Large B-Cell, Diffuse, Neoplasm Recurrence, Local, business, Diffuse large B-cell lymphoma, Fluorescence in situ hybridization
Abstract

Germinal center B-cell-like diffuse large B cell lymphoma (GCB-DLBCL) at diagnosis is associated with superior long-term outcomes compared to non-GCB-DLBCL in patients treated with conventional chemo-immunotherapy. Whether cell of origin (COO) by Hans algorithm retains its prognostic significance in patients with (R/R) relapsed/refractory DLBCL undergoing autologous hematopoietic cell transplant (auto-HCT) is not well established. Three hundred and fifty-seven patients underwent auto-HCT between 2005 and 2018. The COO status was determined in 284 patients and these were included in the analysis. One hundred ninety-four patients had GCB-DLBCL while 90 had non-GCB-DLBCL. Median follow up was 1.7 (0-13) years. The GCB-DLBCL was associated with inferior 5-year overall survival at 44% (95%CI, 36-52) versus 64% (95%CI, 54-77) (P = .004) and a higher relapse incidence at 67% (95%CI, 58-74) versus 49% (95%CI, 35-60) (P = .01) in the non-GCB-DLBCL. The difference between GCB and non-GCB-DLBCL remained statistically significant in multivariate analysis. Additionally, response at the time of transplant was an independent prognostic factor. GCB-DLBCL was enriched in double-hit and triple hit phenotype based on available fluorescence in situ hybridization data. These results suggest an enrichment of high-risk genetic rearrangements in R/R GCB-DLBCL resulting in limited efficacy of auto-HCT.

Published
2022

11. Amplicon-based next-generation sequencing reveals the co-existence of multiple Leishmania species in patients with visceral leishmaniasis

Author

Alberto Paniz-Mondolfi, Jessica Bautista, Martha S. Ayala, Maryi Segura, Juan David Ramírez, Luz H. Patiño, Maryia V. Shaban, Adriana Castillo-Castañeda, and Marina Muñoz

Subjects
Microbiology (medical), Infectious and parasitic diseases, RC109-216, Biology, DNA sequencing, parasitic diseases, medicine, Animals, Humans, In patient, Leishmania infantum, Leishmania species, HSP70, Visceral leishmaniasis, Leishmania, Trypanosomatid, Coinfection, Amplicon-based NGS, High-Throughput Nucleotide Sequencing, General Medicine, Amplicon, medicine.disease, Virology, Co-infection, Infectious Diseases, Leishmaniasis, Visceral, Female
Abstract

Visceral leishmaniasis (VL) is a mammalian protozoal disease propagated in the Americas by female phlebotomine sandflies, mainly caused by Leishmania infantum. However, in recent years, cases of VL caused by different Leishmania species, such as L. amazonensis and L. colombiensis, have been reported in the continent. This study used an amplicon-based next-generation sequencing approach to identify VL aetiologic species using high-depth sequencing targeting a region on the Heat Shock Protein 70 gene. In this first approach, six samples from five patients diagnosed with VL were selected and analysed to identify DNA of Leishmania spp. All samples harboured DNA of L. infantum; five samples were found to be co-infected with other Leishmania spp. or with Trypanosoma cruzi, and just one sample was mono-infected with L. infantum. This study demonstrates the usefulness of this methodology to identify trypanosomatid co-infections in clinical samples, which presents an interesting study panorama considering their biological, clinical and epidemiological implications.

Published
2022

12. More Than an ERAS Pathway is Needed to Meet Target Length of Stay After Pancreaticoduodenectomy

Author

Alicia M. Wilson, George A. Poultsides, John R. Bergquist, Brendan C. Visser, Amy Li, Carlos I. Ayala, Monica M. Dua, Jeffrey A. Norton, and Amy C. Lu

Subjects
medicine.medical_specialty, Ileus, Gastric emptying, business.industry, General surgery, medicine.medical_treatment, Medical record, Anastomosis, Surgical, Length of Stay, medicine.disease, Pancreaticoduodenectomy, Orthostatic vital signs, Pancreatectomy, Postoperative Complications, Cohort, medicine, Humans, Surgery, Enhanced Recovery After Surgery, Complication, business, Gastrointestinal function, Retrospective Studies
Abstract

Background Enhanced Recovery After Surgery (ERAS) protocols have been successfully instituted for pancreaticoduodenectomy (PD). This study evaluates reasons patients fail to meet length of stay (LOS) and areas for pathway improvement. Materials and Methods A multidisciplinary team developed and implemented an ERAS protocol for open PD in 2017. The study includes a medical record review of all patients who were perioperatively managed with the ERAS protocol and failed to meet LOS after PD procedures. Target LOS was defined as 7 d. Results From 2017 to 2020, 44% (93 of 213) of patients using ERAS protocol after PD procedures failed to meet target LOS. The most common reason to fail target LOS was ileus or delayed gastric emptying (47 of 93, LOS 11). Additional reasons included work-up of leukocytosis or pancreatic leak (17 of 93, LOS 14), additional “night” of observation (14 of 93, LOS 8), and orthostatic hypotension (3 of 93, LOS 10). Of these additional 46 patients, 19 patients underwent computed tomography (on or after POD 7) and only four patients received additional inpatient intervention. Conclusions The most common reason for PD pathway failure included slow return of gastrointestinal function, a known complication after PD. The remaining patients were often kept for observation without additional intervention. This group represents an actionable cohort to target for improving LOS through surgeon awareness rather than protocol modification.

Published
2022

13. Comprehensive management of risk factors in peripheral vascular disease. Expert consensus

Author

Pilar Caridad Morata Barrado, Carlos Guijarro Herraiz, Jorge Jesús Martín Cañuelo, J.F. Merino-Torres, Cristina Tejera Pérez, María Ángeles Martínez López, Teresa Rama Martínez, Sergio Cinza-Sanjurjo, Mª Dolores Aicart Bort, C. Brotons, Vicente Pascual Fuster, Emilio Ortega, Tomás Ripoll Vera, Carmen Peinado Adiego, Alberto Cordero, Carlos Jericó Alba, Luis Castilla-Guerra, Francisco Valls-Roca, Pablo Antonio Toledo Frías, Rosa María Sánchez-Hernández, Antonio Pérez Pérez, Ángel Brea Hernando, Juan Girbés Borrás, Miguel Ángel Prieto Díaz, J.M. Mostaza, María Soledad Navas de Solís, Elisa Velasco Valdazo, Estíbaliz Jarauta Simón, Juan Carlos Ferrer García, José Manuel Ruiz Palomar, Francisco M. Morales-Pérez, Julio Sánchez Álvarez, Javier de Juan Bagudá, Núria Muñoz Rivas, Elías Delgado, Manuel Frías Vargas, Ovidio Muñiz Grijalvo, Esther Doiz Artázcoz, Pedro Valdivielso, Adriana Saltijeral Cerezo, Rebeca Reyes García, Manuel Rodríguez Piñero, Beatriz Jiménez Muñoz, Luis Leiva Hernando, Enrique Rodilla Sala, Alfonso Barquilla García, Jose Daniel Mosquera Lozano, Carlos Santos Altozano, Antonio Miguel Hernández Martínez, Alejandro Berenguel Senén, Manuel Gargallo Fernández, María Gloria Cánovas Molina, Julio Antonio Carbayo Herencia, Ignacio Párraga Martínez, Elena Iborra Ortega, Aurora García Lerín, Vicente Ignacio Arrarte Esteban, Vivencio Barrios, Jose Polo García, Manuel Antonio Botana López, Ruth Sánchez Ortiga, Manuel Suárez Tembra, Miguel Brito Banfiel, Ángel Carlos Matía Cubillo, José María Cepeda Rodrigo, Daniel Escribano Pardo, P. Beato, M. Comellas, Inés Gil Gil, R. Campuzano, Martín Ruiz Ortiz, Víctor Rodríguez Sáenz de Buruaga, Agustín Blanco Echevarría, Rosario Lorente Calvo, José Manuel Comas Samper, Sergio Hevia, Natalia de la Fuente, Juan Cosin Sales, Rafael Vidal-Pérez, Virginia Bellido Castañeda, N. Plana, Amelia Carro, Carlos Lahoz, Magdalena León Mazorra, Sergio Martínez Hervas, Maria Seoane Vicente, Melina Vega de Ceniga, M. Antonia Pérez Lázaro, Sergio Jansen Chaparro, Antonio Ruiz García, Isabel Ayala Vigueras, Miren Morillas Bueno, Esther Merino Lanza, Andrés Galarza Tapia, Marta Casañas Martínez, Daiana Ibarretxe Gerediaga, María Durán Martínez, José Antonio Rubio, Óscar Moreno-Pérez, Andrés García León, Luis Estallo Laliena, Eduardo Carrasco Carrasco, Vicente Pallarés-Carratalá, Alberto Zamora Cervantes, Javier Escalada, Juan Carlos Obaya Rebollar, Mercedes Guerra Requena, José Antonio Quindimil Vázquez, Pedro J. Pinés Corrales, Carlos Escobar Cervantes, Lisardo García-Martín, Albert Clarà, Jose María Fernández Rodriguez-Lacin, Miguel Turégano Yedro, Francisco Javier Félix Redondo, Luis Masmiquel, Jacinto Fernández Pardo, Laura Calsina Juscafresa, María Eugenia López Valverde, Eva María Pereira López, Fátima Almagro Múgica, and Agustín Medina Falcón

Subjects
medicine.medical_specialty, Consensus, Vascular disease, business.industry, Arterial disease, Delphi method, Expert consensus, General Medicine, Disease, medicine.disease, Quit smoking, Peripheral Arterial Disease, Risk Factors, Multidisciplinary approach, Diabetes Mellitus, medicine, Humans, Ankle Brachial Index, Medical prescription, Intensive care medicine, business
Abstract

There is currently a degree of divergence among the main clinical practice guidelines on the management of risk factors for peripheral arterial disease (PAD). This project aims to gain understanding of the management of PAD risk factors in clinical practice and to reach a multidisciplinary consensus on the strategies to be followed in order to optimize its identification, treatment, and follow-up.A multidisciplinary consensus following the Delphi methodology.Professionals (n = 130) with extensive experience in PAD participated in this consultation. The results suggest that in order to optimize the control of risk factors, efforts should be aimed at: (1) promoting the involvement and awareness of all specialists in the identification of and screening for the disease; (2) guaranteeing the possibility of evaluating the ankle-brachial index (ABI) in all the medical specialties involved; (3) promoting strategies for patients to quit smoking through the use of drugs, programs, or referrals to specialized units; (4) promoting an appropriate Mediterranean-based diet and the prescription of daily exercise; (5) raising awareness of the importance of ensuring LDL cholesterol values below 70 mg/dL, especially in symptomatic but also in asymptomatic patients (55 mg/dL following the publication of the ESC/EAS guide); (6) recommending the use of antiplatelet therapy in asymptomatic patients with diabetes mellitus (DM) and/or a pathological ABI; and (7) protocolizing the annual evaluation of ABI in high-risk patients.This document presents the 22 agreed-upon strategies which are intended to help professionals optimize multidisciplinary management of PAD risk factors.

Published
2022

14. Distinct visual resolution supports aperture shaping in natural and pantomime-grasping

Author

Maryam Hamidi, Benjamin Tari, Naila Ayala, and Matthew Heath

Subjects
Hand Strength, Aperture, media_common.quotation_subject, GRASP, Experimental and Cognitive Psychology, General Medicine, medicine.disease, Apraxia, Natural (archaeology), Spatial relation, Task (computing), Feedback, Sensory, Perception, Visual Perception, medicine, Humans, Psychology, Psychomotor Performance, media_common, Haptic technology, Cognitive psychology
Abstract

Pantomime-grasping is a "simulated" motor response wherein an individual grasps to an area dissociated from a physical target. The task has been used in the apraxia literature as a proxy for natural grasping (i.e., physically grasping a target); however, it is important to recognize that the task's decoupled spatial relations between stimulus and response renders the top-down processing of target features (e.g., size) that accumulating evidence has shown to be mediated by visual information functionally distinct from natural grasping. Here, we examined whether the visual information supporting pantomime-grasps exhibits a visual resolution power commensurate with natural grasps. Participants were presented with a target and nontarget that differed in size below the perceptual threshold (i.e., 0.5 mm or ∼1.3%) and were asked to make a perceptual judgment about the target (i.e., "smaller" or "larger" than the nontarget) before and after completing natural and pantomime-grasps. Results showed that perceptual judgments "before" and "after" natural and pantomime-grasps did not reliably distinguish between target and nontarget. Natural grasp peak grip apertures (PGAs) scaled to target size and were comparable for "before" and "after" perceptual judgment trials-a result indicating that haptic feedback from physically grasping the target did not "boost" perceptual accuracy. Most notably, pantomime-grasp PGAs were insensitive to target size; that is, responses elicited a visual resolution power less than natural grasps. These results provide convergent evidence that pantomime-grasps are mediated by the same visual information as obligatory perceptions and do not provide a proxy for natural grasps. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Published
2023

15. Predictive and diagnosis models of stroke from hemodynamic signal monitoring

Author

Luis García-Terriza, Gemma Reig Roselló, José L. Risco-Martín, and José L. Ayala

Subjects
Signal Processing (eess.SP), FOS: Computer and information sciences, Computer Science - Machine Learning, medicine.medical_specialty, Stroke recurrence, 0206 medical engineering, Biomedical Engineering, Hemodynamics, Spec#, Computed tomography, 02 engineering and technology, 030218 nuclear medicine & medical imaging, Machine Learning (cs.LG), 03 medical and health sciences, 0302 clinical medicine, FOS: Electrical engineering, electronic engineering, information engineering, Medicine, Electrical Engineering and Systems Science - Signal Processing, Stroke, computer.programming_language, Acute stroke, medicine.diagnostic_test, business.industry, Stroke subtype, medicine.disease, 020601 biomedical engineering, Computer Science Applications, Radiology, business, computer, Signal monitoring
Abstract

This work presents a novel and promising approach to the clinical management of acute stroke. Using machine learning techniques, our research has succeeded in developing accurate diagnosis and prediction real-time models from hemodynamic data. These models are able to diagnose stroke subtype with 30 min of monitoring, to predict the exitus during the first 3 h of monitoring, and to predict the stroke recurrence in just 15 min of monitoring. Patients with difficult access to a CT scan and all patients that arrive at the stroke unit of a specialized hospital will benefit from these positive results. The results obtained from the real-time developed models are the following: stroke diagnosis around 98% precision (97.8% sensitivity, 99.5% specificity), exitus prediction with 99.8% precision (99.8% Sens., 99.9% Spec.), and 98% precision predicting stroke recurrence (98% Sens., 99% Spec.). Graphical abstract depicting the complete process since a patient is monitored until the data collected is used to generate models.

Published
2023
Full Text
View/download PDF

16. Performance of the ESC 0/2h-algorithm using high-sensitivity cardiac troponin I in the early diagnosis of myocardial infarction

Author

Eva Ganovská, Beatriz López, Nicolas Geigy, Adam Bakula, Tobias Reichlin, Òscar Miró, Raphael Twerenbold, Sofia Calderón, Maria Rubini Gimenez, Michael Freese, Thomas Nestelberger, Karin Wildi, Joaquim Gea, Michael Christ, Tobias Zimmermann, Carolina Fuenzalida, Pedro Lopez-Ayala, Damian Kawecki, Christian Puelacher, Beata Morawiec, Eliska Potlukova, Jasper Boeddinghaus, Desiree Wussler, Matthias Diebold, Tobias Resa, Isabel Campodarve, Samyut Shrestha, Noemi Glarner, Katharina Rentsch, Ivo Strebel, Oliver Reuthebuch, Piotr Munzk, Friedrich Eckstein, Luca Koechlin, Christian Mueller, Danielle Menosi Gualandro, Tobias Breidthardt, Jeanne du Fay de Lavallaz, Jiri Parenica, Arnold von Eckardstein, F. Javier Martín-Sánchez, Sandra Mitrovic, Dagmar I. Keller, Esther Rodríguez Adrada, Simon Martin Frey, and University of Zurich

Subjects
medicine.medical_specialty, Cardiac troponin, Myocardial Infarction, 610 Medicine & health, 030204 cardiovascular system & hematology, 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, 540 Chemistry, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Myocardial infarction, reproductive and urinary physiology, 10038 Institute of Clinical Chemistry, urogenital system, business.industry, Chest discomfort, Troponin I, Reproducibility of Results, Emergency department, medicine.disease, Triage, 3. Good health, Early Diagnosis, embryonic structures, Cardiology, biological phenomena, cell phenomena, and immunity, Cardiology and Cardiovascular Medicine, business, Algorithms, Biomarkers
Abstract

The 2020 guidelines of the European Society of Cardiology (ESC) recommend a novel ESC 0/2h-algorithm as the preferred alternative to the ESC 0/1h-algorithm in the early triage for rule-out and/or rule-in of Non-ST-segment-elevation myocardial infarction (NSTEMI). The aim was to prospectively validate the performance of the ESC 0/2h-algorithm using the high-sensitivity cardiac troponin I (hs-cTnI) assay (ARCHITECT) in an international, multicenter diagnostic study enrolling patients presenting with acute chest discomfort to the emergency department.

Published
2021

17. Recommendations of the Mexican College of Rheumatology for the management of psoriatic arthritis

Author

Julio Casasola-Vargas, Diana Flores-Alvarado, Luis H. Silveira, Sandra Sicsik-Ayala, Greta Reyes-Cordero, Guadalupe Villanueva Quintero, Mario Amaya Guerra, Sara G. Reyes Orozco, Beatriz E. Zazueta Montiel, Roberto Hernández-Paz, Angélica Mendoza-Fuentes, Ana G. Bernard-Medina, Alejandra López Rodriguez, Rosa E. Barbosa Cobos, Rubén Burgos-Vargas, and César Pacheco-Tena

Subjects
medicine.medical_specialty, Ankylosing spondylitis, business.industry, Sacroiliitis, General Medicine, Disease, medicine.disease, Rheumatology, Psoriatic arthritis, Quality of life (healthcare), Psoriasis, Internal medicine, Family medicine, medicine, Life expectancy, business
Abstract

Psoriatic arthritis is a chronic systemic inflammatory disease that affects the skin, musculoskeletal structures and other organs and systems compromising functionality, quality of life and reducing the life expectancy of patients. It is a complex disease that requires specialist and timely care and management. The alternatives for treating the manifestations of psoriatic arthritis have increased and the effect of the different agents on specific manifestations has been clarified in recent studies. Therefore, we should incorporate the available evidence to build a strategy for the treatment of these patients. The Mexican College of Rheumatology selected a committee to evaluate these different alternatives and make recommendations. Methods The study group included 16 rheumatologists and 3 certified dermatologists, selected from different health institutions and regions of the country. An executive committee was formed to coordinate the meetings and a committee of experts selected the literature search criteria, prepared the research questions, rated the quality of the evidence, and produced the recommendations in the different disease domains based on the GRADE methodology. Results 24 updated recommendations were generated for the treatment of patients with psoriatic arthritis. The recommendations establish the role of the drugs currently available in our country. The importance of adequate disease control is emphasized, individualizing the level of involvement of each patient in each of the six domains potentially affected by the disease. In addition, the sequence in the choice of treatments available for each domain is established, based on their efficacy, safety profile and accessibility. Conclusions With this consensus document, it will be possible to improve the care of patients with psoriatic arthritis. The recommendations were generated based on the best available information and in consideration of the Mexican health system.

Published
2021

18. The coexistence of low albumin levels and obesity worsens clinical outcomes among subjects admitted for sars-cov-2 infection

Author

Keyla Dotres, Joana Nicolau, Luisa Ayala, Pilar Sanchis, Antelm Pujol, Lluís Masmiquel, Irene Rodríguez, and Andrea Pompeo Romano

Subjects
medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Fibrinogen, Asymptomatic, Gastroenterology, Procalcitonin, Albumins, Internal medicine, Humans, Medicine, Obesity, Hypoalbuminemia, Retrospective Studies, Nutrition and Dietetics, SARS-CoV-2, business.industry, Albumin, COVID-19, medicine.disease, Pneumonia, Original Article, medicine.symptom, business, medicine.drug
Abstract

Background and aims The clinical spectrum of the SARS-CoV-2 infection is very broad, ranging from asymptomatic infection to severe pneumonia. However, the majority of fatalities related to COVID-19 have involved old, frail and patients with comorbidities, such as obesity, groups that also have high rates of a poor nutritional status. To assess the impact on clinical outcomes of the coexistence of any degree of obesity and low albumin levels on admission among patients with COVID-19. Methods This is a sub-analysis of a former study where 75 patients admitted due to COVID-19 were evaluated cross-sectionally. In this analysis, patients were divided in two groups, according to the presence of obesity and albumin levels on admission lower than 3.5 g/dl. Results 11 out 75 patients evaluated (14.7%) had obesity and albumin levels lower than 3.5 g/dl. Patients with obesity and hypoalbuminemia were older than patients without these two conditions (65.3 ± 7.7 vs 54.2 ± 17 years; p = 0.01). CRP (141.4 ± 47.9 vs 70.1 ± 60.6 mg/l; p = 0.002), D-dimer (2677.3 ± 2358.3 vs 521.7 ± 480.3 ng/ml; p = 0.001), fibrinogen (765.9 ± 123.9 vs 613.5 ± 158gr/L; p = 0.007) ferritin levels (903.1 ± 493 vs 531.4 ± 418.9 mcg/l; p = 0.01) and procalcitonin (3.5 ± 0.6 vs 1.1 ± 0.7 ng/ml; p = 0.009) were significantly higher in the group with obesity and hypoalbuminemia. Among patients with low albumin and obesity, length of hospital was higher (21.9 ± 18.7 vs 10.5 ± 9.5 days; p = 0.004) and the proportion of subjects admitted to ICU was greater (81.8% vs 11.5%; p

Published
2021

19. Etiology and outcome of febrile children coming from the tropics

Author

Cinta Moraleda, Pablo Rojo, David Torres-Fernandez, Alfredo Perez Rivilla, Daniel Blázquez-Gamero, Cristina Epalza, Luis Manuel Prieto Tato, Ana Perez-Ayala, and Elisa Fernandez Cooke

Subjects
0301 basic medicine, Microbiology (medical), Pediatrics, medicine.medical_specialty, Adolescent, Fever, 030106 microbiology, Communicable Diseases, Dengue fever, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Tropical Medicine, Global health, Humans, Medicine, 030212 general & internal medicine, Child, Travel, business.industry, Infant, Tropics, medicine.disease, Intensive care unit, Malaria, Child, Preschool, Tropical medicine, Etiology, business, Pediatric population
Abstract

Introduction International travelers have grown significantly over last years, as well as imported diseases from tropical areas. Information in pediatric population is scarce. We describe demographic and clinical characteristics of febrile children coming from the tropics. Methods Retrospective review of patients under 18 years old, presenting at a tertiary hospital and surrounding primary health care centers between July 2002 and July 2018 with a stay in a tropical region during the previous year. Patients were selected from microbiological charts of thick smears for malaria or dengue serologies. Results 188 patients were studied: 52.7% were born in Spain with a median age of 3.0 years old (IQR 1.5–8.0). Main regions of stay were Sub-Saharan Africa (54.8%) and Latin America (29.8%), mostly for visiting their friends and relatives (56.3%), followed by recent arrival migrants (32.4%). Only 34% of travelers attended pre-travel consultation. More than 80% of these febrile children attended directly the Emergency Room. The most frequent diagnoses were febrile syndrome without source (56.4%), respiratory condition (15.4%) and acute diarrhea (11.7%). Around a half (52.1%) were managed as outpatients, but 46.2% were hospitalized and 7.4% were admitted to Intensive Care Unit. No specific diagnosis was achieved in 24% of cases. However, 29.7% were diagnosed with malaria. Conclusion Children with fever coming from tropical areas were at risk of severe infectious diseases. Malaria was diagnosed in one out of four and 7% required admission in PICU. This information emphasizes the need of reinforcing training about tropical diseases among first line physicians.

Published
2021

20. Critical view of the myopectineal orifice: a scoring system to objectively evaluate transabdominal preperitoneal inguinal hernia repair

Author

Antonio Marmolejo, Carlos Armando Navarro, Alain Sánchez, Sergio Ayala, Jorge Daes, Jorge Farell, Ana Paula Ruiz Funes, Nubia Andrea Ramírez, and Luis Julián Alpírez García

Subjects
medicine.medical_specialty, Scoring system, business.industry, Hernia, Inguinal, Objective method, Surgical Mesh, medicine.disease, Objective assessment, Surgery, Inguinal hernia, Cronbach's alpha, Internal consistency, medicine, Expert evaluation, Humans, Laparoscopy, business, Herniorrhaphy, Transabdominal preperitoneal
Abstract

BACKGROUND More than 20 million inguinal hernia repair (IHR) procedures are performed worldwide every year. The critical view of the myopectineal orifice (CV of the MPO) is a stepwise guide to the achievement and standardization of minimally invasive IHR (MI IHR). We propose a scoring system as an objective method for fulfillment of the CV of the MPO. METHODS The scoring system was employed for evaluation of the transabdominal preperitoneal (TAPP) technique in 15 video-recorded procedures. Two variants of the score were used: the simple CV of the MPO score (s-CVMPO score) and the extended CV of the MPO score (e-CVMPO score). The inter-rater agreement and internal consistency for both scores and the correlation between the two scores were assessed. RESULTS Inter-rater agreement with respect to satisfactory/unsatisfactory achievement of the CV of the MPO was high for both the s-CVMPO and e-CVMPO scores (κ = 1, p

Published
2021

21. 0/2 h-Algorithm for Rapid Triage of Suspected Myocardial Infarction Using a Novel High-Sensitivity Cardiac Troponin I Assay

Author

Carolina Mitrovic, Esther Rodriguez Calderón, Tobias Munzk, Joaquim Campodarve, Maria Rubini Gimenez, Thomas Nestelberger, F. Javier Martín-Sánchez, Sandra Rentsch, Gea, Luca Koechlin, Michael Christ, Christian Zimmermann, Christian Mueller, Bernhard Okamura, Gemma Martínez-Nadal, Eva Adrada, Noemi Fuenzalida, Jiri Ganovská, Katharina Geigy, Desiree Wussler, Sofia López, Eliska du Fay de Lavallaz, Jeanne Puelacher, Pedro Lopez-Ayala, Karin Wildi, Dagmar I. Keller, Michael Breidthardt, Ana Yufera Sanchez, Matthias Potlukova, Nicolas Diebold, Beata Morawiec Piotr Glarner, Adam Strebel, Simon Bakula, Arnold Parenica, Beatriz Freese, Damian Kawecki, Isabel von Eckardstein, Òscar Miró, Danielle M Frey, Jasper Boeddinghaus, Samyut Shrestha, Jennifer Rohner, Tobias Gualandro, and Raphael Twerenbold

Subjects
medicine.medical_specialty, Cardiac troponin, business.industry, Internal medicine, Biochemistry (medical), Clinical Biochemistry, medicine, Cardiology, Myocardial infarction, Sensitivity (control systems), medicine.disease, business, Triage
Abstract

Background We aimed to derive and validate a 0/2 h-algorithm using the new high-sensitivity cardiac troponin I (hs-cTnI)-VITROS assay (VITROS® Immunodiagnostic Products hs-Troponin I Reagent Pack, Ortho Clinical Diagnostics) for rapid rule-out/in of non-ST-segment elevation myocardial infarction (NSTEMI). Methods The final diagnosis was centrally adjudicated by 2 independent cardiologists according to the fourth universal definition of myocardial infarction (MI) among 1888 patients presenting to the emergency department with acute chest pain. hs-cTnI-VITROS concentrations were measured at presentation and at 2 h in a blinded fashion. The optimal assay-specific thresholds for the hs-cTnI-VITROS 0/2 h-algorithm were derived in a randomly selected 70% of the cohort and validated in the remaining 30%. Results NSTEMI was the final diagnosis in 216/1322 (16.3%) patients of the derivation cohort. Rule-out was defined as baseline hs-cTnI concentrations of 3 h or a baseline hs-cTnI concentration of Conclusion hs-cTnI-VITROS concentrations at presentation combined with absolute changes within the first 2 h allowed safe rule-out and accurate rule-in of NSTEMI in two-thirds of unselected patients presenting with acute chest pain to the emergency department. Trial registration www.clinicaltrials.gov: NCT0047058

Published
2021

22. IgG Subclasses and Congenital Transmission of Chagas Disease

Author

Freddy Tinajeros, Robert H. Gilman, Edward Valencia-Ayala, Cristian Roca, Billy Scola, Sassan Noazin, Edith S. Málaga-Machaca, Peru, Natalie M. Bowman, Maria Del Carmen Menduiña, and Manuela Verastegui

Subjects
Adult, Male, Chagas disease, Bolivia, medicine.medical_specialty, Blood transfusion, Trypanosoma cruzi, medicine.medical_treatment, Article, law.invention, Pregnancy, Risk Factors, law, Virology, parasitic diseases, Humans, Medicine, Chagas Disease, biology, business.industry, Obstetrics, Infant, Newborn, Igg subclasses, biology.organism_classification, medicine.disease, Healthy Volunteers, Infectious Disease Transmission, Vertical, Infectious Diseases, Increased risk, Transmission (mechanics), Case-Control Studies, Immunoglobulin G, Pregnancy Complications, Parasitic, Trypanosoma, Female, Parasitology, Congenital transmission, business
Abstract

The mechanism of vertical transmission of Trypanosoma cruzi is poorly understood. In this study, we evaluated the role of IgG subclasses in the congenital transmission of Chagas disease. We conducted a case-control study in a public maternity hospital in Santa Cruz, Bolivia, enrolling women at delivery. Thirty women who transmitted T. cruzi to their newborns (cases), and 51 women who did not (controls) were randomly selected from 676 total seropositive women. Trypanosoma cruzi–specific IgG1, IgG2, and IgG3 levels were measured by in-house ELISA. The IgG4 levels were unmeasurable as a result of low levels in all participants. Quantitative polymerase chain reaction results and demographic factors were also analyzed. One-unit increases in normalized absorbance ratio of IgG1 or IgG2 levels increased the odds of congenital T. cruzi transmission in Chagas-seropositive women by 2.0 (95% CI: 1.1–3.6) and 2.27 (95% CI: 0.9–5.7), adjusted for age and previous blood transfusion. Odds of congenital transmission were 7.0 times higher in parasitemic mothers (95% CI: 2.3–21.3, P < 0.01) compared with nonparasitemic mothers. We observed that all mothers with IgG1 ≥ 4 were transmitters (sensitivity = 20%, specificity = 100%). Additionally, no mothers with IgG2 < 1.13 were transmitters (sensitivity = 100%, specificity = 21.6%). We demonstrated that IgG subclasses and parasite presence in blood are associated with vertical transmission of T. cruzi and could identify women at increased risk for congenital transmission by measuring IgG subclasses. These measures have potential as objective screening tests to predict the congenital transmission of Chagas.

Published
2021

23. Initial survival of the Isis® total trapeziometacarpal prosthesis with conical trunk threaded cups

Author

M.Á. de la Red-Gallego, J. Rodríguez-Fernández, F. del Canto-Álvarez, M.R. Sánchez-Crespo, H. Ayala-Gutiérrez, J. Couceiro-Otero, and Universidad de Cantabria

Subjects
Trapeziometacarpal osteoarthritis, Survival, medicine.medical_treatment, 030230 surgery, Prosthesis, 03 medical and health sciences, 0302 clinical medicine, Rizartrosis del pulgar, Functional results, Prótesis totales trapeciometacarpianas, medicine, Orthopedics and Sports Medicine, Statistical analysis, Resultados funcionales, Total trapeziometacarpal prostheses, Trapeziometacarpal prosthesis, Orthopedic surgery, 030222 orthopedics, Supervivencia, business.industry, medicine.disease, Trunk, Estudio prospectivo, Threaded anchorage prosthesis, Cúpula roscada, Surgery, Nuclear medicine, business, RD701-811
Abstract

Introducción El tratamiento de la rizartrosis del pulgar mediante la implantación de prótesis totales está en continua expansión. La prótesis Isis® es un implante de cúpula troncocónica de anclaje roscado y semiconstreñida. Nuestro objetivo fue valorar los resultados funcionales y de supervivencia de este implante durante un mínimo de un año de evolución. Material y método Estudio prospectivo sobre 53 prótesis Isis® implantadas entre abril de 2014 y enero de 2019. Se evaluaron el test funcional de Van Cappelle, dolor, fuerza, movilidad, regreso a la actividad, variables radiológicas y colocación de la cúpula. La técnica quirúrgica se realizó siempre con aguja guía centrada en el trapecio y control de escopia. Se registraron complicaciones y se llevó a cabo un análisis estadístico. Resultados Se revisaron 51 implantes (49 pacientes) con un seguimiento medio de 2,1 años (1-5,7). El test de Van Cappelle, el dolor, la movilidad y la fuerza de puño y pinza mejoraron significativamente; también la distancia entre cabeza de metacarpiano y base de trapecio. El 96% de los pacientes regresaron en menos de 6 meses a sus actividades. Las complicaciones registradas fueron: 3 tendinopatías de De Quervain, 2 fracturas de metacarpiano y 2 de trapecio intraoperatoriamente, y un síndrome del túnel carpiano. No hubo ninguna luxación, infección ni movilización del implante en el último seguimiento. Conclusiones Los resultados funcionales de la prótesis Isis® son excelentes a corto plazo, con una supervivencia del 100% tras el primer año de evolución. Las complicaciones surgidas fueron escasas. El anclaje y colocación de la cúpula guiada por escopia parecen ser cruciales para el buen resultado. Introduction The treatment of trapeziometacarpal osteoarthritis through the implantation of total trapeziometacarpal prostheses is in continuous expansion. The Isis® prosthesis is a trunk-conical threaded anchorage prosthesis. Our objective was to assess the functional results and survival of this implant for at least one year of follow-up. Material and method Prospective study on 53 Isis® prosthesis, implanted from april 2014 to january 2019. The Van Cappelle functional test, pain, strength, mobility, return to previous activity, radiological variables and placement of the trapezial component were evaluated. The surgical technique was performed with a guide wirefocused on the trapezius and control of the scopia. Observed complications were recorded and statistical analysis was performed. Results Fifty-one implants (49 patients) were reviewed. Mean follow-up was 2.1 years (1-5.7). Van Cappelle's test, pain, mobility, and grip and clamp strength improved significantly, as did the distance between the metacarpal head and the trapezius base; 96% of the patients returned in less than 6 months to their activities. Minor complications, 3 De Quervain's tendinopathy and 2 intra-operative metacarpal and 2 trapezium fractures were recorded, and one carpal tunnel syndrome. There was no dislocation, mobilization, or implant infection. Conclusions The functional results of the Isis® prosthesis are excellent in the short term, far exceeding the first year of 100% of survival. The complications that arose were minor and few. The anchorage and placement of the trapezial component guided by scopia seem to be crucial for the good result.

Published
2021

24. Third-trimester repeat HIV testing: it is time we make it universal

Author

Irina R. Cassimatis, Laurie D. Ayala, Patricia M. Garcia, Lynn M. Yee, Emily S. Miller, and Jennifer Jao

Subjects
medicine.medical_specialty, HIV seroconversion, Cost-Benefit Analysis, Pregnancy Trimester, Third, HIV Infections, Hiv testing, Third trimester, HIV Testing, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, medicine, Humans, 030212 general & internal medicine, Hiv transmission, 030219 obstetrics & reproductive medicine, Obstetrics, business.industry, Health Policy, Incidence (epidemiology), virus diseases, Obstetrics and Gynecology, HIV screening, medicine.disease, Antiretroviral therapy, Infectious Disease Transmission, Vertical, Practice Guidelines as Topic, Female, Illinois, business
Abstract

Since the 1990s, perinatal transmission of HIV has decreased substantially, largely as a result of improved detection secondary to routine HIV screening in pregnancy and the use of antiretroviral therapy. However, despite reductions in HIV transmission, elimination of perinatal transmission, defined as an incidence of perinatal HIV infection of1 per 100,000 live births and a transmission rate of1%, remains elusive. An estimated 80% of perinatal transmissions occur after 36 weeks' gestation, which highlights the importance of diagnosis and treatment of maternal HIV infection before the highest-risk period for perinatal transmission. With timely identification of seroconversion, intrapartum and neonatal interventions can lower the risk of perinatal transmission from 25% to 10%, substantially reducing perinatal transmission events. The American College of Obstetricians and Gynecologists and the Centers for Disease Control and Prevention recommend that routine HIV testing be performed in all pregnancies, as early in the prenatal course as possible. Third-trimester repeat testing is only recommended for individuals known to be at high risk of acquiring HIV (ie, those who are incarcerated; who reside in jurisdictions with elevated HIV incidence; who are receiving care in facilities that have an HIV incidence in pregnant women1 per 1000 per year; or have signs or symptoms of acute HIV). However, among reproductive-age women, heterosexual intercourse is the most common mode of HIV transmission, and the risk of HIV seroconversion is greater during pregnancy than outside of pregnancy. Furthermore, state statutes for HIV testing in pregnancy are largely lacking. In this clinical opinion, we reviewed the evidence in support of universal third-trimester repeat HIV testing in pregnancy using a successful state-mandated testing program in Illinois. In addition, we provided clinical recommendations to further reduce missed perinatal transmission cases by implementing universal third-trimester repeat testing, obtaining hospital buy-in, monitoring testing adherence, bridging communications across multidisciplinary teams, and engaging clinicians in advocacy work.

Published
2021

25. Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka

Author

Madhubhani Hemachandra, Kazutoshi Fujioka, Mayumi Ishizuka, H M Ayala S Herath, S. K. Weragoda, Kumiko Taira, Yoshiko Aoyama, Yoshinori Ikenaka, Tomonori Kawakami, Makiko Komori, Nirmalie Pallewatta, and Jean-Marc Bonmatin

Subjects
Male, Insecticides, Pyridines, Thiazines, urologic and male genital diseases, Guanidines, Gastroenterology, Dinotefuran, Neonicotinoids, chemistry.chemical_compound, Tandem Mass Spectrometry, Chronic kidney disease, Surveys and Questionnaires, Farmers, Multidisciplinary, Geography, Middle Aged, Nitro Compounds, Thiacloprid, Diarrhea, Kidney Tubules, Medicine, Female, medicine.symptom, Thiamethoxam, Adult, Quality Control, medicine.medical_specialty, Urinary system, Science, Urinalysis, Fatty Acid-Binding Proteins, Article, Renal tubular dysfunction, Internal medicine, Interstitial nephritis, medicine, Humans, Pharmacokinetics, Cystatin C, Renal Insufficiency, Chronic, Sri Lanka, business.industry, Neonicotinoid, Diagnostic markers, medicine.disease, Thiazoles, chemistry, Etiology, Nervous System Diseases, business, Biomarkers, Chromatography, Liquid, Kidney disease
Abstract

Neonicotinoids are systemic insecticides used since the 1990’s , that possess renal tubular toxicity. We conducted a field-based descriptive study in the North Central Dry-zone of Sri Lanka, where chronic kidney disease (CKD) of unknown etiology has been increasing since the 1990’s. To elucidate the relationship between renal tubular dysfunctions and urinary neonicotinoids concentrations, we collected spot urine samples from15 CKD patients, 15 family members, and 62 neighbors in 2015, analyzed two renal tubular biomarkers, Cystatin-C and L-FABP, quantified seven neonicotinoids and a metabolite N-desmethyl-acetamiprid by LC–MS/MS; and we investigated their symptoms using a questionnaire. Cystatin-C and L-FABP had a positive correlation (p N-Desmethyl-acetamiprid was detected in 92.4% of the urine samples, followed by dinotefuran (17.4%), thiamethoxam (17.4%), clothianidin (9.8%), thiacloprid and imidacloprid. Dinotefuran and thiacloprid have never been registered in Sri Lanka. In High Cystatin-C group (> 70 μg/gCre, n = 7), higher urinary concentration of dinotefuran (p = 0.009), and in Zero Cystatin-C group (N-desmethyl-acetamiprid (p = 0.013), dinotefuran (p = 0.049), and thiacloprid (p = 0.035), and more complaints of chest pains, stomachache, skin eruption and diarrhea (p

Published
2021

26. Retinal Lineage Therapeutic Specific Effect of Human Orbital and Abdominal Adipose-Derived Mesenchymal Stem Cells

Author

Shira Weisthal Algor, Oded Ohana, Itay Nakdimon, Shay Keren, Igal Leibovitch, Ayala Elhikis, Ran Ben Cnaan, Moshe Benhamou, Aya Barzelay, Bryan Krief, Anouk Savir Kadmon, Adiel Barak, Anat Loewenstein, and Ilan Feldman

Subjects
Retinal degeneration, Programmed cell death, Pathology, medicine.medical_specialty, Article Subject, business.industry, Mesenchymal stem cell, Adipose tissue, Retinal, Cell Biology, medicine.disease, RC31-1245, Embryonic stem cell, Transplantation, chemistry.chemical_compound, chemistry, medicine, sense organs, business, Internal medicine, Molecular Biology, Research Article, Retinal regeneration
Abstract

Retinal degenerative diseases are one of the main causes of complete blindness in aged population. In this study, we compared the therapeutic potential for retinal degeneration of human mesenchymal stem cells derived from abdominal subcutaneous fat (ABASCs) or from orbital fat (OASCs) due to their accessibility and mutual embryonic origin with retinal tissue, respectively. OASCs were found to protect RPE cells from cell death and were demonstrated to increase early RPE precursor markers, while ABASCs showed a raise in retinal precursor marker expression. Subretinal transplantation of OASCs in a mouse model of retinal degeneration led to restoration of the RPE layer while transplantation of ABASCs resulted in a significant restoration of the photoreceptor layer. Taken together, we demonstrated a lineage-specific therapeutic effect for either OASCs or ABASCs in retinal regeneration.

Published
2021

27. Omission of day +11 methotrexate dose and allogeneic hematopoietic cell transplantation outcomes: results of a systematic review/meta-analysis

Author

Hemant S. Murthy, Mohamed A. Kharfan-Dabaja, Ernesto Ayala, Farah Yassine, Arni Kumar, Mahmoud Aljurf, Katelyn Keller, Andre Fernandez, Tea Reljic, and Madiha Iqbal

Subjects
Oncology, Transplantation, medicine.medical_specialty, Transplantation Conditioning, business.industry, Hematopoietic Stem Cell Transplantation, Graft vs Host Disease, Hematology, Disease, medicine.disease, Calcineurin, Methotrexate, Recurrence, Internal medicine, Meta-analysis, Toxicity, medicine, Mucositis, Humans, Prospective Studies, business, Complication, medicine.drug
Abstract

Allogeneic hematopoietic cell transplantation (allo-HCT) is potentially curative for patients with malignant and benign hematologic conditions. Graft-versus-host disease (GVHD) is a known complication of allo-HCT that results in significant morbidity and mortality. A common GVHD prophylaxis strategy combines a calcineurin inhibitor with methotrexate. When mucositis and organ toxicity develop, the day +11 dose is frequently omitted to limit further organ damage. The potential impact of this practice on allo-HCT outcomes is unclear as published data show conflicting results. Thus, we performed a systematic review/meta-analysis of the available literature to assess the impact of omitting day +11 methotrexate on allo-HCT recipients. Data were extracted in relation to benefits (overall survival [OS], progression-free survival [PFS]) and harms (acute and chronic GVHD, non-relapse mortality [NRM], and relapse). Pooled OS rate favored those who received day +11 methotrexate vs. those who did not (HR = 1.21; 95% CI = 1.02-1.43; p = 0.03). There was no significant difference in pooled rates of PFS (HR = 0.96; 95% CI = 0.60-1.52; p = 0.85), acute GVHD (HR = 1.03; 95% CI = 0.35-2.98; p = 0.96), chronic GVHD (HR = 0.83; 95% CI = 0.44-1.57; p = 0.57), NRM (HR = 0.86; 95% CI = 0.67-1.11; p = 0.25), and relapse (HR = 0.97; 95% CI = 0.75-1.26; p = 0.83) between the two groups. Large prospective multicenter studies are needed to better define the significance of day +11 methotrexate omission.

Published
2021

28. Efectividad de la ritmo terapia en las funciones cognitivas durante el aislamiento Covid-19

Author

Josselyn Gabriela Bonilla Ayala, Geovanna Cristina Almeida Villegas, and Alicia Zavala Calahorrano

Subjects
medicine.medical_specialty, Wilcoxon signed-rank test, business.industry, Significant difference, Cognition, medicine.disease, Test (assessment), Informed consent, Intervention (counseling), Physical therapy, Medicine, Dementia, business, Pathological
Abstract

Introducción: En el año 2020 la OMS lo reconoce como pandemia la presencia del virus SARS-Cov-2, las entidades gubernamentales adoptaron medidas de confinamiento para salvaguardar la salud de los adultos mayores (AM), el aislamiento social se relaciona con el deterioro de las funciones cognitivas, siendo necesario implementar la ritmo terapia (RT) para mejorar su estilo de vida. Objetivo: Establecer la efectividad de la ritmo terapia en las funciones cognitivas de los adultos mayores durante el confinamiento por Covid-19. Material y métodos: Se realizó una investigación con enfoque cuantitativo y cuasi-experimental, la intervención fue aprobada por el comité de bioética de la Universidad Técnica de Ambato. Participaron 20 adultos entre 65 años o más, quienes firmaron el consentimiento informado; se aplicó 12 sesiones de ritmo terapia de 45 minutos una vez por semana; evaluando el deterioro mediante el test de Minimental antes y después de la intervención. Para el análisis estadístico se utilizó el sistema informático SPSS versión 25.0 y se aplicó la prueba estadística de Chi cuadrado y Wilcoxon. Resultados: En la evaluación inicial presentaron los AM funciones cognitivas normales (30-27) con el 45%, el 25% con sospecha patológica (26-24), 25% deterioro (23-12) y solo el 5% demencia (9-11). Sin embargo en la post-intervención se observó efectos positivos en las funciones cognitivas representando un 85% normal, el 10% sospecha patológica y el 5% deterioro. Se observa que la técnica de RT fue efectiva para el deterioro cognitivo en la post intervención con una diferencia significativa del 5%, P=0.004. Conclusión: La intervención mejoró las funciones cognitivas en la población adulta mayor, permitiéndoles un envejecimiento activo y saludable.

Published
2021

29. Reimagining Perinatal Mental Health: An Expansive Vision For Structural Change

Author

P. Mimi Niles, Inas K. Mahdi, Wendy Davis, Fleda Mask Jackson, Aza Nedhari, Caitlin R. Williams, Sayida Peprah, Sequoia Ayala, Vu An Foster, Monica R. McLemore, Nastassia K. Davis, Jamila B. Perritt, Ifeyinwa V. Asiodu, Jasmine Getrouw-Moore, and Jessica M. Harrison

Subjects
Oppression, Poverty, business.industry, Health Policy, media_common.quotation_subject, Mental illness, medicine.disease, Structural violence, Mental health, Racism, Developmental psychology, Health care, medicine, business, Psychology, Psychosocial, media_common
Abstract

Diagnoses of depression, anxiety, or other mental illness capture just one aspect of the psychosocial elements of the perinatal period. Perinatal loss; trauma; unstable, unsafe, or inhumane work environments; structural racism and gendered oppression in health care and society; and the lack of a social safety net threaten the overall well-being of birthing people, their families, and communities. Developing relevant policies for perinatal mental health thus requires attending to the intersecting effects of racism, poverty, lack of child care, inadequate postpartum support, and other structural violence on health. To fully understand and address this issue, we use a human rights framework to articulate how and why policy makers must take progressive action toward this goal. This commentary, written by an interdisciplinary and intergenerational team, employs personal and professional expertise to disrupt underlying assumptions about psychosocial aspects of the perinatal experience and reimagines a new way forward to facilitate well-being in the perinatal period.

Published
2021

30. Shock Cryptic, emerging diagnostic

Author

Ricardo J. Ayala García, Sandra Soto Ticse, Stephany Matos Santiváñez, and Allison Ortiz de Orue

Subjects
Medicine (General), medicine.medical_specialty, Physical examination, shock, Timely diagnosis, sepsis, Sepsis, R5-920, medicine, Medical history, Intensive care medicine, ácido láctico, medicine.diagnostic_test, business.industry, lactic acid, General Medicine, Emergency department, medicine.disease, Blood pressure, Shock (circulatory), Medicine, medicine.symptom, business, Perfusion
Abstract

Cryptic shock is a poorly identified clinical entity, and it still describes a patient with signs of tissue hypoperfusion without affecting blood pressure. In the emergency department, it is important to identify signs of hypoperfusion and evaluate various hidden sources of infection by taking a complete medical history, a thorough physical examination, and, if necessary advanced imaging. It is necessary to conclude that the importance of the timely diagnosis of this clinical entity helps to improve the prognosis significantly. El shock críptico es una entidad clínica poco identificada, describe aún paciente con signos de hipoperfusión tisular sin afectación de la presión arterial. En el departamento de emergencia es importante identificar signos de hipoperfusión y evaluar diversas fuentes ocultas de infección realizando una historia clínica completa, un examen físico exhaustivo y de ser necesario imagenología avanzada. Es necesario concluir que la importancia del diagnóstico oportuno de esta entidad clínica ayuda a mejorar significativamente el pronóstico.

Published
2021

31. Early prenatal diagnosis of double inlet left ventricle

Author

Moshe Bronshtein, Ron Beloosesky, Yuval Ginsberg, Osnat Zmora, Nizar Khatib, Ayala Gover, and Zeev Weiner

Subjects
medicine.medical_specialty, Heart malformation, Heart Ventricles, Gestational Age, Prenatal diagnosis, Ultrasonography, Prenatal, Pregnancy, Prenatal Diagnosis, medicine, Humans, Retrospective Studies, Fetus, medicine.diagnostic_test, Obstetrics, business.industry, Infant, Obstetrics and Gynecology, Gestational age, medicine.disease, Bays, Double inlet left ventricle, Pediatrics, Perinatology and Child Health, Female, Trisomy, business, Fetal echocardiography
Abstract

Objective The aim of this study to describe the presentation of double inlet left ventricle (DILV) very early in prenatal life, to assess its prevalence and to portray the associated anomalies. Methods This was a retrospective study which included all the women who attended our clinic for early fetal screening sonography, between 2006 and 2020. Most of the screening was done at 14-16 weeks of gestation (except one high risk pregnancy, which was performed at nine gestational weeks), and included an anatomic fetal scan and Doppler imaging. The diagnosis of DILV was done based on sonographic features of abnormal four-chamber view. Complete fetal echocardiography was carried out to rule out additional heart malformations. Results Out of 26,805 early prenatal transvaginal ultrasound screening examinations, 14 cases of DILV were diagnosed. The gestational age range of our DILV diagnosis was 9-16 gestational weeks. All pregnancies were terminated as per parental request. In five fetuses, a chromosomal analysis was performed, one had trisomy 21, and the rest fetuses had a normal karyotype. In two fetuses, an autopsy was performed and the diagnosis of DILV was confirmed in both. Conclusions Very early prenatal detection of DILV is possible and may have an implication in parent decision regarding their pregnancy future.

Published
2021

32. Lymphocytoma cutis (cutaneous B‐cell pseudolymphoma): study of 102 cases with emphasis on the histological characteristics and immunohistochemistry of the miliarial type

Author

Romina A Villalobos-Ayala, Marina Ramos-Suárez, Alberto Tlacuilo-Parra, Marco A Rodríguez-Castellanos, Guillermo Solis-Ledesma, América A Espinoza-Gurrola, and Elizabeth Guevara-Gutiérrez

Subjects
CD20, Pathology, medicine.medical_specialty, Skin Neoplasms, biology, business.industry, Rare entity, Retrospective cohort study, Dermatology, Middle Aged, Cutaneous B-cell pseudolymphoma, Immunoglobulin light chain, Lymphocytoma cutis, medicine.disease, Immunohistochemistry, Cutaneous lymphoma, Diagnosis, Differential, Pseudolymphoma, biology.protein, Humans, Medicine, Female, business, Retrospective Studies
Abstract

BACKGROUND Lymphocytoma cutis (LC) is a benign reactive lymphoproliferative B-cell process. It has two variants: localized type with solitary lesions and miliarial type with numerous lesions. The objective was to investigate the characteristics of LC with emphasis on the miliarial type. METHODS Retrospective study, patients with clinical and histopathological diagnosis of LC were included. Age, sex, evolution time, affected site, and type of treatment were investigated. In miliarial-type LC, the histological and immunohistochemical characteristics were also investigated. RESULTS In an 18-year period, there were 102 patients found with LC: 72 (71%) corresponded to females, the median age was 45 years, the median evolution time was 4 months, and the face was the most predominant affected area in 81 (79%) cases. Localized-type LC corresponded to 88 (86%) cases, and miliarial type in 14 (14%). The most common treatment was surgery, which was used in 32 (31%) patients, all of whom had localized type (P

Published
2021

33. Initial analysis of the dosimetric benefit and clinical resource cost of CBCT‐based online adaptive radiotherapy for patients with cancers of the cervix or rectum

Author

Mahmoud Ahmed, A. Bapsi Chakravarthy, Adam D. Yock, Diandra Ayala-Peacock, and Michael Price

Subjects
adaptive therapy, medicine.medical_specialty, Colorectal cancer, Planning target volume, Uterine Cervical Neoplasms, Rectum, motion management, medicine, Radiation Oncology Physics, Humans, Radiology, Nuclear Medicine and imaging, Clinical significance, online adaptive radiotherapy, Adaptive radiotherapy, Instrumentation, Cervix, Cervical cancer, Radiation, business.industry, Radiotherapy Planning, Computer-Assisted, Sigmoid colon, Radiotherapy Dosage, Spiral Cone-Beam Computed Tomography, medicine.disease, medicine.anatomical_structure, adaptive radiotherapy, Female, Radiotherapy, Intensity-Modulated, Radiology, business, adaptive replanning, ART, Radiotherapy, Image-Guided
Abstract

Purpose This provides a benchmark of dosimetric benefit and clinical cost of cone‐beam CT‐based online adaptive radiotherapy (ART) technology for cervical and rectal cancer patients. Methods An emulator of a CBCT‐based online ART system was used to simulate more than 300 treatments for 13 cervical and 15 rectal cancer patients. CBCT images were used to generate adaptive replans. To measure clinical resource cost, the six phases of the workflow were timed. To evaluate the dosimetric benefit, changes in dosimetric values were assessed. These included minimum dose (Dmin) and volume receiving 95% of prescription (V95%) for the planning target volume (PTV) and the clinical target volume (CTV), and maximum 2 cc's (D2cc) of the bladder, bowel, rectum, and sigmoid colon. Results The average duration of the workflow was 24.4 and 9.2 min for cervical and rectal cancer patients, respectively. A large proportion of time was dedicated to editing target contours (13.1 and 2.7 min, respectively). For cervical cancer patients, the replan changed the Dmin to the PTVs and CTVs for each fraction 0.25 and 0.25 Gy, respectively. The replan changed the V95% by 9.2 and 7.9%. The D2cc to the bladder, bowel, rectum, and sigmoid colon for each fraction changed −0.02, −0.08, −0.07, and −0.04 Gy, respectively. For rectal cancer patients, the replan changed the Dmin to the PTVs and CTVs for each fraction of 0.20 and 0.24 Gy, respectively. The replan changed the V95% by 4.1 and 1.5%. The D2cc to the bladder and bowel for each fraction changed 0.02 and −0.02 Gy, respectively. Conclusions Dosimetric benefits can be achieved with CBCT‐based online ART that is amenable to conventional appointment slots. The clinical significance of these benefits remains to be determined. Managing contours was the primary factor affecting the total duration and is imperative for safe and effective adaptive radiotherapy.

Published
2021

34. Survival from a Triple Co-Infection of COVID-19, HIV, and Tuberculosis: A Case Report

Author

Diriba Ayala, Belay Bekele, Reta Tsegaye, Siraj Shiferaw, Tesfaye Shibiru, Tadesse Tolossa, and Bizuneh Wakuma

Subjects
Pediatrics, medicine.medical_specialty, Tuberculosis, Productive Cough, Referral, business.industry, COVID-19, HIV, Case Report, General Medicine, medicine.disease, medicine.disease_cause, Bloody, Regimen, PTB, co-infection, medicine, Sputum, Ethiopia, Presentation (obstetrics), medicine.symptom, business, Nasal cannula
Abstract

Introduction: The triple burden of COVID-19, human immune virus (HIV), and TB co infection is one of the contemporary challenges to this globe. People living with chronic medical diseases such as HIV and TB are more likely to experience poor outcomes from COVID-19. This study aimed to report survival from triple co-infection with PTB, HIV, and COVID-19 in Wollega University referral hospital (WURH), western Ethiopia. Case Presentation: A 55-year-old male known HIV patient on HAART for the last 3 years presented to WURH on May 26, 2021, with chief complaints of shortness of breath of 5 days' duration associated with productive cough, history of high-grade fever, and severe headache. He had produced a lot of bloody sputum one month prior to the current complaints. On 1st day of his presentation, a Gene Expert test was done from sputum, and he was positive for pulmonary TB. On the same day, a nasopharyngeal sample for COVID-19 using polymerase chain reaction (PCR) was positive. On his 2nd day of admission, he was transferred to the COVID-19 treatment center with the diagnosis of severe COVID-19, PTB, and WHO stage-3 RVI. During his stay in the hospital, he was provided with oxygen via a nasal cannula. Intensive phase anti-TB treatment was initiated on the 3rd day of admission. HAART was continued with the same regimen he was taking prior to his presentation. On June 6, 2021, the patient was recovered and discharged from the hospital after 10 days of hospital stay. Conclusion: This case report suggests, after 10 days of admission with triple infections, there is a good clinical prognosis and survival from COVID-19. On admission, further diagnosis and investigations of TB co-infection should be performed for all patients admitted with COVID-19 due to their similar and non-specific clinical manifestations.

Published
2021

35. Change in opioid and analgesic use for headaches after aneurysmal subarachnoid hemorrhage over time

Author

Carolina B. Maciel, C. Jones, V. Viswanathan, A. Ayala, Y. Li, W.C. Fox, Katharina M. Busl, Brandon Lucke-Wold, and G. Aiello

Subjects
Subarachnoid hemorrhage, Narcotic, medicine.medical_treatment, Analgesic, 03 medical and health sciences, 0302 clinical medicine, Aneurysm, medicine, Humans, Medical prescription, Retrospective Studies, Analgesics, business.industry, Headache, Guideline, Subarachnoid Hemorrhage, medicine.disease, Analgesics, Opioid, Opioid, 030220 oncology & carcinogenesis, Anesthesia, Female, Surgery, Neurology (clinical), Headaches, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Background Severe headache, a hallmark of aneurysmal subarachnoid hemorrhage (aSAH), affects up to 90% of patients during hospitalization. Opioids remain the guideline recommended mainstay of acute therapy despite their significant side effects and potential for tolerance and addiction. We evaluated time trends in opioid prescriptions, hypothesizing a decline with increasing recognition of the opioid crisis. Methods We performed a retrospective review of patients with aSAH admitted to a single tertiary care center between 2012 and 2019 and included patients with Hunt-Hess-Grade ≤ 3 who were able to verbalize pain scores. Collected variables included mean and maximum daily headache scores, aneurysm treatment modality, and daily analgesic medication doses. Results Of 340 patients with aSAH, 114 (86 from 2012–2016 and 28 from 2017–2019) were included. Of the included patients, 86/114 (75.4%) were female. Patients in the 2012–2016 had a median age of 55 compared to 63 in the 2017–2019 group (P = 0.02). Otherwise, there was no significant difference in demographic data including time in hospital, treatment option utilized, or aneurysm characteristics. Maximal daily headache score ranged from 6 to 8 for 2012–2016 and 5 to 8 for 2017–2019 cohorts. Average oral morphine equivalents (in mg) administered during hospitalization were similar between groups (2012–2016: 251 ± 345 95% CI [178,323]; 2017–2019: 207 ± 237 95% CI [119,295]; P = 0.319). When prescribed, doses of opioids provided at discharge were less in the more recent group (2012–2016: 84.4 ± 78.9 95% CI [57.5, 111]; 2017–2019: 38.1 ± 20.2 95% CI [33.7, 42.5]; P = 0.004) Conclusion Despite recognition of important drawbacks of opioid use for headache control, and efforts to reduce opioid use during hospitalization, we found that utilization during hospitalization for SAH did not decrease over time. Maximal headache scores remained similar in the studied time periods, indicative of insufficient pain relief. This points out a pressing need to further investigate alternative opioid and narcotic sparing strategies for patients with SAH.

Published
2021

36. Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Author

Labeau, Sonia O, Afonso, Elsa, Benbenishty, Julie, Blackwood, Bronagh, Boulanger, Carole, Brett, Stephen J, Calvino-Gunther, Silvia, Chaboyer, Wendy, Coyer, Fiona, Deschepper, Mieke, François, Guy, Honore, Patrick M, Jankovic, Radmilo, Khanna, Ashish K, Llaurado-Serra, Mireia, Lin, Frances, Rose, Louise, Rubulotta, Francesca, Saager, Leif, Williams, Ged, Blot, Stijn I, Dritan, Muzha, Antoni Margarit Ribas, Fernando, Lipovesty, Cecilia, Loudet, Fiona, Coyer, Philipp, Eller, Nafseen, Mostafa, Patrick, M Honoré, Vanesa Mercado Telleria, Jasmina, Smajic, Paula Cristina Nogueira, Khalid Mahmood Khan Nafees, Romuald, Hentchoya, Louise, Rose, Javiera, Soledad, Frances, Lin, Yenny, Cardenas, Amylkar Garay Reyes, Alan, Sustic, Meropi, Mpouzika, Tamas, Vymazal, Hanne Irene Jensen, Hernan, Aguirre-Bermeo, Liivi, Maddison, Maija, Valta, Silvia, Calvino-Gunther, Frank, Bloos, Faustina Excel Adipa, Vasilios, Koulouras, Judy, Enamorado, Zsuzsann, Ágoston, Hrönn, Birgisdóttir, Amit, Gupta, Mohan, Gurjar, Bram, Kilapong, Seyed Mohammadreza Hashemian, Ignacio, Martin-Loeches, Julie, Benbenishty, Andrea, Cortegiani, Kelly, Fletcher, Yoshiro, Hayashi, Wangari, Waweru-Siika, Khalid, Abidi, Sang-Min, Lee, Burhan, Hadri, Mihails, Dolgusevs, Fayez François Abillama, Tomas, Jovaisa, Cyril, Thix, Muhammed, Elhadi, Basri Mat Nor, Shanti, Ratnam, Mohd Zulfakar Mazlan, Sundaresan, Maiyalagan, Luis, Sánchez-Hurtado, Adrian, Belii, Mendsaikhan, Naranpurev, Prabha, Gautam, Dylan De Lange, Rachael, Parke, Rose Ekama Ilesanmi, Mirjana, Shosholcheva, Antonija, Petosic, Ranveig, Lind, Madiha Hashmi Ffarcsi, Javier, Bogarin, Aaron Mark Hernandez, Malgorzata, Mikaszewska-Sokolewicz, Bruno, Sousa, Dana, Tomescu, Dorel, Sandesc, Theogene, Twagirumugabe, Vitaly, Gusarov, Maie, Ebaid, Radmilo, Jankovic, Gari, Slobodianiuk, Andrea, Martonova, Rihard, Knafelj, Mervyn, Mer, Emilio, Maseda, Bernardo, Panka, Joerg, C Schefold, Eva, Joelsson-Alm, Konlawij, Trongtrakul, Lorna, Merritt-Charles, Lamia Ouanes Besbes, Yalım, Dikmen, Lesia, Zgrzheblovska, Mark, Fielding, Francesca, Rubulotta, Ashish, K Khanna, Leif, Saager, Ingrid von der Osten, Alban, Greca, Alma, Cani, Nordian, Xhindi, Genci, Hyska, Antonio Margarit Ribas, Susana, Pinto, Paulo, Alves, Romina, Esposito, Emanuel, Valgolio, John Thomas Sanchez Minope, Antonio, Abdala, Maria, Ayala, Silvina, Bravo, Ana, Bantar, Patricia, Delgado, Gustavo, Badariotti, Fernando, Lipovestky, Ana, Diaz, Pablo, Saul, Mariano, Setten, Alejandra, Aucapina, Ysica, Acosta, Victor, Gonzalez, Luis, Camputaro, Fernando, Baccaro, Robert, Villa, Marcela, Mastantuono, Emiliano, Dean, Oscar Fernández Rostello, Patricia, Brizuela, Julio Ricardo Bartoli, Matias, Guereschi, Cristian, Quiroga, Sofia, Putruele, Paula, Villegas, Veronica, Curilen, Ruben, Fernandez, Mariangeles Gabriela Nocheretti, Rosana Gabriela Escalante, Cecilia Inés Loudet, Silvia, Fernandez, Ana Laura Gonzalez, Gustavo Andres Alvarez, Federico, Iglesias, Silvia, Chaparro, Graciela, Zakalik, Gonzalo, Pagella, Matías, Baini, Pierina Arias Campos, Ignacio, Sabbag, Armando, Schmukler, Imelda Perdomo Fonseca, Gonzalo Martín Alvarez, Mario, Ramirez, Fernando, Tapia, Carlos Alejandro Bascary, Graciela Del Valle Gimenez, Fernando Pablo Bertoletti, Esteban, Milioto, Pablo Julio Maldonaldo Bonsignore, Maria Alejandra Fernandez, Julie, Smith, Tim, Chimunda, Lorraine, Thompson, Teena, Maguire, Wendy, Chaboyer, Stacey, Watts, Marion, Mitchell, Madeleine, Powell, India, Lye, Leanne, Parsons, Nerilee, Baker, Claire, Reynolds, Amy, Thompson, Kristy, Masters, Kellie, Sosnowski, Lynette, Morrison, Gavin, D Leslie, Ramanathan, Lakshmanan, Alexis, Tabah, Wendy, Brown, Sharon, McDowell-Skaines, Andrea, Mclucas, Chris, Smith, Mandy, Tallot, Sarah, Jones, Michelle, Barakat-Johnson, Thomas, Leong, Rand, Butcher, Kerrie, Martin, Philipp, Douschan, Dirk von Lewinski, René, Schmutz, Uta, Kolussi, Fatema, Salman, Zainab, Ateya, Koen De Decker, Niels Van Regenmortel, Anita, Jans, Patricia, Wijnands, Stefano, Coremans, Patrick, M Honore, David De Bels, Tanja, Depuydt, Caroline, Paillet, Luc-Marie, Jacquet, Walter, Swinnen, Francis, Hannes, Matthia, Mergeay, Stijn Van de Velde, Silvie, Allaert, Pieter, Hoste, Christophe, Borin, Sandrine, Balon, Vincent, Fraipont, Patrick, Biston, Nicolas De Schryver, Thierry, Dugernier, Ilse Van Cotthem, Angelica Olivetto de Almeida, Silvia Angelica Jorge, Delmiro, Becker, Raysa Cristina Schmidt, Evellyn, Oliveira, Aline, Ramalho, Eliane, Mazocoli, Audrey, Fioretti, Elaine, Barros, Leticia, Serpa, Suzana, Bianchini, Ticiane, Campanili, Taís, Pantaleao, Paulo Carlos Garcia, Ana Lucia Vitti Ronchini, Rayanne, Santos, Nurulhuda Binti, A Manap, Sean, Bagshaw, Dominic, Carney, Jon, Davidow, Ella, Rokosh, Andréa Maria Laizner, Samantha, Smith, Megan, Mcquirter, Betty Star Kampayana, René, Favre, Martin, Sills, Julie, Dallaire, Cathy, Becker, Sherissa, Microys, Bonnie, Bowes, Jennifer, Lajeunesse, Rishi, Ghosh, Jacqueline, Baptiste-Savoie, Rose, Raizman, Gabriel, Suen, Noushin, Taghavi, Orla, Smith, Clare, Fielding, Julieta, Canales, Pia, Molina, Javiera, Chaparro, Maria Idalia Sepulveda, Matias Jesús Flamm Zamorano, Pamela, Rocha, Ximena, Villanueva, Paola, Araya, Meneses, Dayan, Fernando, Avalos, Xiaohan, Li, Liu, Yu, Xinxia, Li, Xiaoyan, Chen, Zhixia, Jiang, Jing, Yang, Jingfang, Chen, Lei, Yang, Kefang, Wang, Jie, Gao, Xiuhua, Fang, Ronghua, Zhao, Xinhua, Xia, Hongmei, Liu, Jing, Li, Haiyan, Wang, Gen, Meng, Yanhong, Di, Damei, Wang, Rong Hua Zhao, Li Ping Hu, Peipei, Xu, Qing Feng Jiao, Hai Yun Wang, Chun Jie Xia, Yan, Liu, Mei, Ye, Yan, Wan, Wenmei, Wang, Yajun, Ding, Aiua, Ren, Yan, Gao, Qi, Li, Guifang, Du, Yanling, Shen, Yanming, Ding, Ning, Li, Cui, Yuan, Lei, Tan, Qiang, Lin, Hailing, Guo, Howe, Yan, Xiao, Xu, Wei, Zhang, Jinxian, Liang, Libing, Zhang, Eryun, Tian, Qian, Zhao, Lin, Insu, Jingwen, Dong, Yanmei, Gu, Ying, Liu, Lina, Zhao, Wei, Wang, Hongmei, Qiao, Lili, Tuo, Mengmeng, Lv, Jin Yu Zhu, Jifen, Zhu, Ying, Wei, Man, Liu, Yin, He, Jiyin, Cheng, Jin, Liu, Jia, Na, Dongfang, Wei, Qing, Li, Xiaoying, Wu, Huan, Duan, Dongliang, Lin, Qiong, Liang, Xiaofang, Luo, Yunfeng, Xiong, Rong Fen Huang, Jing, Fu, Tao, Zan, Man, Ye, Zeya, Shi, Yanfei, Long, Yang, Lei, Xiaodi, Liu, Chen, Yumei, Lingling, Wang, Yali, Zhang, Yan, Xu, Cheng, Wang, Zhijuan, Chengxia, Sun, Jinhui, Song, Yingli, Wang, Xiumei, Liu, Yupeng, Liu, Yuxia, Yuan, Qingping, Huang, Fengling, Yang, Yun, Wu, Xianping, Luo, Xiaowu, Bai, Hong, Zheng, Min, Song, Yue, Sun, Zhangshuangzi, Li, Feifei, Luo, Miao, Liu, Li Chuntang Li, Xinjian, Li, Guiping, Zhang, Lina, Xiao, Tingting, Yu, Guangyuan, Gao, Wei, Wei, Fanglan, Wang, Ting, Han, Tingting, Li, Zeng, Qi, Jing Mei Zeng, Yan, Long, Fuqun, Pan, Jing, Wang, Guoxue, He, Haiyan, Chen, Feifei, Zhang, Chao, Yu, Gao, Chunhua, Xiuying, Yao, Dongmei, Bai, Liu, Lu, Xuelian, Xu, Yan, Wang, Xuejuan, Liang, Zhang, Na, Aizhi, Zhang, Xiaochun, Hu, Hui, Zhang, Ruixia, Wang, Poon Shing Tak, Sung Wai Ho, Qun Xia Jiang, Xinran, Ding, Liu, Hong, Limei, Miao, Zhaoxia, Feng, Liping, Huang, Juan, Wu, Yuping, Wang, Jiye, Guo, Baoke, Zhang, Chaoqun, Ma, Han, Yu, Congcong, Liu, Min, Ding, Linlin, Luan, Jing, Zheng, Shanshan, Lv, Shumin, Jiang, Wenzhen, Cao, Xiujuan, Xue, Guangyan, Liu, Xiyan, Wei, Youru, Jiang, Zhiru, Yao, Gao, Li, Jinhua, Li, Wenwen, Zhao, Mei, Jiang, Junping, Hao, Jing, Zhang, Caiju, Song, Feifei, Chen, Shuhui, Wang, Lili, Hu, Deyan, Cao, Jianhong, Wan, Xiaomin, Wang, Hongyan, Shao, Zhenxia, Zhang, Xia, Cui, Jingyu, Liu, Lijuan, Zhao, Xingguo, Li, Limei, Fan, Ling, Zhang, Min, Yu, Biyan, Li, Chunxia, Li, Ling, Liu, Xuelian, Liu, Wenmin, Chen, Yan, Li, Zhang, Zhigang, Yuchen, Wu, Chenghau, Mu, Guoyan, Zhu, Fan, Yang, Qi, Bo, Ling, Li, Meili, Chen, Jing Hua Jiang, Hai, Yin, Xuelian, Pang, Yue Ying Gong, Shunzhu, Yang, Xiaoli, Yan, Xianhong, Zheng, Dehong, Lei, Lei, Lei, Yinhua, Guo, Lihong, Liu, Jing, Yu, Wei, Sun, Aiping, Bi, Weiwei, Li, Yang, Wu, Ji, Li, Dongshu, Ni, Zijing, Wu, Bing, Song, Qin, Fei, Yang, Xiaoyan, Qiong, Ran, Xixi, Li, Xueping, Jiao, Hua, Ji, Sun, Zhiping, Hong, Ma, Jianhong, Mu, Yanhua, Hao, Yin, Li, Ying, Wang, Caihong, Hui, Wenjie, Ju, Yuxia, Huo, Yuxia, Wang, Lei, Chen, Yan, Yan, Qingli, Zhao, Hongjuan, Chen, Guijun, Bao, Ying, Cao, Hong, Li, Hong, Zhang, Ying, Zhang, Lina, Xu, Jia, Guixiang, Ying, Li, Hui Min Zhao, Xia, Huang, Zhaoxing, Dai, Yanman, Jian, Hongsu, Zhang, Zhixia, Tian, Zu Qing Cao, Miao, Li, Yang, Liu, Fei, Ouyang, Fuying, Ma, Wangyan, Jin, Liuyan, Ge, Shifen, Wu, Weilian, Yuan, Tianfei, Chen, Guanxiu, Shi, Zhihong, Chen, Kewei, Liu, Xue, Lin, Yuemen, Ly, Sun, Lijuan, Xiao Fang Tian, Shuo, Wang, Zhangxia, Feng, Xiaozhe, Liu, Yunchun, Dong, Jundi, Zhang, Nie, Bocui, Guoxian, Wang, Yingjuan, Zhao, Xiaojun, Wu, Qiao, Yang, Rongjun Ling Hu, Xue Qin Li, Zhu Jun Yu, Yanlan, Yao, Xiaoqiong, Deng, Yan, Xiao, Yan, Xie, Yanping, Yang, Huai, Yang, Yuming, Zhou, Zhuqing, Li, Min, Xiao, Yongxia, Yang, Yani, Tian, Luz Marina Silva Gama, Juan Sebastian Hernandez, Nestor, Caicedo, Jorge, Marin, Maria-Elena, Ochoa, Monica, Gomez, José, Rojas-Suarez, Jeniffer, Gonzalez, Amylkar José Garay Reyes, Edwin, Chapeta, Estefania, Orozco, Ina, Filipović-Grčić, Anita, Vuković, Suzana, Pečenković, Aleksandar, Šuput, Gordana, Zivanovic-Posilovic, Armanda, Bozena, Nikolina, Udiljak, Morena, Milic, Renata Curic Radivojevic, Slobodan, Mihaljevic, Marijana, Matas, Dinko, Tonkovic, Hemena, Čuljak, Ivana, Herceg, Gordana, Pavlisa, Milena, Dobric, Tatjana, Beker, Višnja Nesek Adam, Tanja, Goranovic, Chrysanthos, Markoulias, Mina, Mathaios, Maria, Mylordou, Eleni, Achilleos, Pavlina, Kleanthous, Veronika, Kotanidi, Maria, Foka, Iwy, Charalabous, Anna, Alexandrou, Marios, Georgiou, Artemis, Patsalos, Sofia, Zepoy, Constantina, Constantinou, Petr, Piza, Tomas, Vymazal, Elisabeth, Wiborg, Louise, Bruhn, Karin, Kaasby, Karin Rehnholt Pedersen, Sanne, Mikkelsen, Marie, Collet, Anne, Langvad, Hanne, Andresen, Susanne, Fischer, Inger Ebbesen Kjærgård, Britta, Jepsen, Birthe, Husted, Morten, Bestle, Anne Marie Kodal, Tina Charlotte Bitsch Hansen, Anne Sofie Bomholt Pedersen, Tina Damgaar Thomsen, Anisette, Hoegenhaven, Mette, From, Tine Melgaard Frandsen, Grit, Henning, Anja, Hansen, Inger Abildgaard Bliksted, Luis Mario Tamayo, Pedro, Mogrovejo, Carolina, Palaez, Diego Rolando Morocho Tutillo, Cintia Valencia Hurtado, Maria Fernanda García, Diana, Alvarez, Fausto, Guerrero, Alexandra, Vasquez, Martin, Kütimets, Kadri, Tamme, Eneli, Anvelt, Lomangisi, Dlamini-Sserumaga, Carita, Löfqvist, Virpi, Lusenius, Outi, Kauppi, Jenni-Katarina, Sakki, Tarja, Tervo-Heikkinen, Ulla, Kesti, Merja, Merilainen, Elina, Karjula, Minna, Peltomaa, Auli, Palmu, Maarit, Ahtiala, Maija Anniina Valta, Hervé, Mentec, Gaëtan, Plantefève, Guillaume, Besch, Sébastien, Pili-Floury, Stanislas, Ledochowski, Marc Danguy des Déserts, Christophe, Giacardi, Cédric, Daubin, Audrey, Massard, Yann Le Guen, Agnès, Blanc, Simon, Mandaroux, Silvia Calvino Günther, Prune, Avogadro, Anthony, Radavidson, Jean, Turc, Sébastien, Jochmans, Hervé, Quintard, Laetitia, Boyer, Cédric, Bruel, François, Philippart, Philippe, Montravers, Enora, Atchade, Nadine, Flessel, Benoît, Chinardet, Léa, Soulisse, Cindy, Pillard, Delphine, Ngo, Benjamin, Bongiorno, Nathalie, Heitzler, Virginie, Souppart, Nathalie, Gautheret, Jean-Francois, Timsit, Fatiha, Essardy, Muriel, Fartoukh, Daisy, Mehay, Fabienne, Etourneau, Jean-Christophe, Farkas, Pascal, Beuret, Gabriel, Preda, Etienne De Montmollin, Vincent, Castelain, Ulrich, Jaschinski, Monika, Rothenfusser, Detlef, Kindgen-Milles, Thomas, Dimski, Christine, Fiedler, Tobias, Heinicke, Patrick, Meybohm, Tobias, Schulze, Marc, Bota, Sabrina, Pelz, Tobias, Odenthal, Martin, Christ, Kathrin, Bösl, Achilleas, Chovas, Sebastian, Stehr, Philipp, Simon, Sarah, Grotheer, Sebastian, Schüppel, Stefan, Schaller, Lea, Albrecht, Andeas, Stübner, Stephan, Graeser, Nina, Kolbe, Martina, Lausch, Anja, Diers, Ulf, Guenther, Reimer, Riessen, Martin, Roller, Irene Pearl Osei, Anita-Chrysolyte, Kusi-Appiah, Yakubu, H Yakubu, Belinda, Guadi-Gosh, Christos, Dragoumanis, Christos, Christofis, Nikolaos, Kazakos, Styliani, Bastani, Charalampos, Martinos, Vasileios, Bekos, Metaxia, Papanikolaou, Theonymfi, Papavasilopoulou, Anna, Efthymiou, Vasiliki, Chantziara, Anna, Kyriakoudi, Nikolaos, Kakaras, Chrisi, Diakaki, Aikaterini, Flevari, Charikleia, Nikolaou, Kounougeri, Katerina, Lamprini, Avramopoulou, Kyriaki, Tsikritsaki, Georgios, Gkiokas, Eirini, Pantiora, Chrysostomos, Katsenos, Eirini-Chysovalanto, Patsiou, Paraskevi, Alexandropoulou, Ioannis, Koutsodimitropoulos, Epaminontas, Farmakis, Konstantina, Nestora, Marinos, Chatzis, Eumorfia, Kondili, Stella, Soundoulounaki, Ourania, Mousafiri, Dimitra, Lepida, Antonia, Liarmakopoulou, Georgios, Papathanakos, Mrina, Oikonomou, Panagiotis, Ioannides, Dimitrios, Papadopoulos, Ioannis, Staikos, Maria, Stafylaraki, Bogdan, Raitsiou, Konstantinos, Mandis, Ifigenia, Ravani, Styliani, Kourelea, Aikaterini, Efthimiou, Giannoula, Thoma, Apostolos, Bakas, Konstantinos, Psarulis, Souzana, Anisoglou, Eirini, Papageorgiou, Evangelia, Michailidou, Thomai, Tholioti, Athena, Lavrentieva, Evdokia, Sourla, Anastasia, Spyropoulou, Nikolaos, Pantelas, Kristina Mariana Matei Stalika, Ioannis, Georgakas, Antigoni, Karathanou, Syragoula, Tsikriki, Aikaterini, Dimoula, Sofia, Kanakaki, Aristeidis, Vakalos, Konstantinos, Pagioulas, Judy Enamorado Enamorado, Gabor, Nardai, Fatime, Hawchar, Asbjorn, Blondal, Brynja, Rygvadottir, Rannveig, J Jonasdottir, Hrönn, Birgisdottir, Bhagyesh, Shah, Shuchi, Kaushik, Swagata, Tripathy, Mukta, Singh, Sonika, Agarwal, Manish, Gupta, Meraj, Ahmad, Kishore, Mangal, Vaibhav, Bhargava, Vilas, Kushare, Simant, Jha, Lakshay, Bhakhtiani, Manoj, Kamal, Arvind, Baronia, Ade, Susanti, Mayang Indah Lestari, Zulkifli, Zulkifli, Windu, Baskoro, Farid, Zand, Fatemeh, Zarei, Ata, Mahmoodpoor, Farshad, Heidari, Fateme, Jafaraghaee, Aidan, O'Shea, Fiona, O'Shea, Caroline, O'Donnell, Geraldine, Craig, Gerry, Fitzpatrick, Lisa, Dunne, Jennifer, Hastings, Brian, Marsh, Caitriona, Cody, Elizabeth, Campbell, Deirdre, Doyle, Michelle, Pacturanan, Christine, Sheehan, Annette, Carey, Charlotte, Carter, Regina, Mulvey, Damien O'Connell Rosemary Finn, Catherine, Motherway, Amy, Walsh, Jennifer, Kehoe, Shella, Delossantos, Jennifer, Lalor, Siobhan, O'Nuallain, Helena, Behan, Sandra, Mcpherson, Ailesh, Corcoran, Patricia, Gordon, Glenda, Rooney, Dassy, Levy, Mazal, Azencot, Vladimir, Gurevich, Alinoy, Lavy, Valentina, Bendelari, Romina, Marconi, Antonio, Barone, Chiara, Gatti, Andrea, Giampaoletti, Cinzia, Borgognoni, Davide Massimo Ghioldi, Arena, Raimondo, Giacomo, Castiglione, Anna Vita Bruno, Giorgia, Rubulotta, Antonella, Mo, Amalia, Corso, Salvatore, Girianni, Andrea, Bruni, Eugenio, Garofalo, Salvatore Maurizio Maggiore, Alessandro Di Risio, Italo, Calamai, Rosario, Spina, Savino, Spadaro, Carlo Alberto Volta, Antonella, Cotoia, Lucia, Mirabella, Laura, Maulicino, Giancarlo, Abregal, Maria, Donvito, Paolo, D'Ambrosio, Filipo, Binda, Ileana, Adamina, Alessandro, Galazzi, Alessandra, Negro, Rosanna, Vaschetto, Fabio, Capuzzi, Margherita, Boschetto, Lucia, Stivanello, Luciano, Bonaccorso, Chiara, Megna, Pasquale, Iozzo, Antonino, Rizzo, Giovanni, Scire, Maria Rosa Taibi, Francesca Paola Tranello, Antonio, Manzo, Lidia, Traina, Beatrice, Pastore, Attilio, Quaini, Gian Domenico Giusti, Gloria, Montaldi, Federica, Piergentili, Federica, Mancini, Simona, Casaioli, Francesco, Uccelli, Fabio, Guarracino, Adriana, Onelli, Valentina Di Gravio, Maria, Cossu, Oliva, Matrona, Monica, Rocco, Daniela, Alampi, Federica, Dellafiore, Flavia, Ranalli, Matteo, Bossolasco, Elisabetta, Brizio, Pina, Migliorino, Paolo, Cortellazi, Moris, Rosati, Francesco, D'Ambrosio, Catia, Quagliotto, Erik, Roman-Pognuz, Alberto, Peratoner, De Rosa, Silvia, Marina Alessandra Martin, Francesca De Sanctis, Paolo, Ciorba, Patrick, Toppin, Hyacinth, Harding-Goldson, Shunsuke, Taito, Nobuaki, Shime, Ryohey, Yamamoto, Fumiya, Kanda, Akemi, Hirao, Moritoki, Egi, Ayako, Noguchi, Satoru, Hashimoto, Umeda, Aya, Hideaki, Sakuramoto, Akira, Ohuchi, Jun, Kataoka, Kumi, Maruyama, Izumi, Nakayama, Yoshimasa, Nishime, Koji, Fujimoto, Kenji, Takahashi, Mayumi, Tsujimoto, Masako, Shimizu, Eunice, Tole, Malcolm, C Correia, Je Hyeong Kim, Sunghoon, Park, Kyung Chan Kim, Jonghyun, Baek, Jung-Min, Bae, So Young Park, Tai Sun Park, Heung Bum Lee, Seung Yong Park, Jisoo, Park, Lee, Yeon-Joo, Cho, Young-Jae, Sang-Miin, Lee, Kyeongman, Jeon, Seok Chan Kim, Jongmin, Lee, Hyun Keun Chee, Jin Won Huh, Yun Su Sim, Junghyun, Kim, Youjin, Chang, Jong-Joon, Ahn, Byung Ju Kang, Won-Yeon, Lee, Seok Jeong Lee, Nehat, Baftiu, Ivasr, Krastins, Sonia, Stiban, Michel El Feghaly, Elie, Gharios, Marie, Merheb, Mohamed, Benlamin, Ala, Khaled, Wesal Ali Belkhair, Majd, Tabib, Firas, Ashour, Ahmed, Elhadi, Osama Wanees Emhemid Tababa, Taha, Khaled, Soad Imhmed, R Alkhumsi, Abdualhamid, I Alshrif, Ahmed Ali Aboufray, Aya, Alabuzidi, Ahmed Ramadan Triki, Mala, Elgammudi, Hajer Ben Zahra, Enas, Soula, Maram Milud Said Al-Alawi, Hazem, Ahmed, Mohamed Abdurazzag Ali Ghula, Saulius, Vosylius, Lucie, Mouton, Touraj, Rastegar, Claude, Sertznig, Gilles, Martin, Christian, Theisen, Christian, Ferretti, Fränk, Gils, Marc, Gallion, Asmah, Zainudin, Laila Kamaliah Kamalul Bahrin, Shanti Rudra Deva, Azmin Huda Abdul Rahim, Sherliza, Wahab, W Nazaruddin, W Hassan, Wan Nasrudin Wan Ismail, Mohd Nazri Ali, Tien Meng Khoo, Noryani Mohd Samat, Jenny May Geok Tong, Nik Azman Nik Adib, Mohd Basri Mat Nor, Shanthi, Ratnam, Nahla, Ismail, Siti Rohayah Sulaiman, Kit Weng Foong, Anita, Alias, Ngu Pei Hua, Jorge Macias Zermeno, Daniel, Blanco, Karely, Duran, Claudia Lizbeth Lopez Nava, San Juan Roman Nandyelly, Luis Alejandro Sanchez-Hurtado, Brigitte, Tejeda-Huezo, Mario Del Moral Armengol, Luis Pedro Ambriz Nava, Jorge Guerra Herrera, Gilberto Felipe Vazquez de Anda, Humberto, Gallegos-Perez, Nancy, Hernandez-Sanchez, Lucia, Hernandez-Ponce, Luis, Gorordo-Delsol, Marcos, Hernandez-Romero, Saira, Gomez, Fernando, Molinar, Silvio, A Ñamendys-Silva, Juan, P Romero-Gonzalez, Daira, Gonzalez, Antonio, Landaverde, Miguel Ángel Sosa, Berenice, Navarro, José Ivan Rodriguez de Molina Serrano, Sergio Reyes Iburrigarro, Alejandro, Ibarra, Joaquin, Aguirre, Mayra, Martinez-Gonzalez, Nayeli Rocio Cañas Padilla, Ana Alícia Velarde Pineda, Missael Vladimir Espinoza Villafuerte, María Ocotlan Gonzalez Herrera, Battsetseg, Baasanjav, Abdelhamid, Hachimi, Mina, Elkhayari, Tarek, Dendane, Nisha Bhandari Subedi, Sabina Dhakal Pathak, Meena, Manandhar, Laura Van Gulik, Mark Van Den Brink, Peter Van Vliet, Benjamin, Gerretsen, Lettie Van Den Berg, Marina De Haan, Binny, Tuinstra, Paul, Kuijpers, Jennifer, Reijntjens, Jan Wytze Vermeijden, Martin, Rinket, Margijske, Vanroest, Auke, Reidinga, Bert, Loef, Willem, Dieperink, Marisa, Onrust, Tom, Dormans, Laura, Bormans, Matty, Koopmans, Rik, T Gerritsen, Arlette Van Den Elst, Mirjam, Evers, Oscar, Oiting, Rob, Wilting, Bart, Ramaker, Mark van der Kuil, Jan-Willem, Fijen, Lenneke, Haas, Jasper, Haringman, Lynette, Newby, Eileen, Gilder, Danielle, Hacking, Rica, Dagooc, Rima, Song, Hansjoerg, Waibel, Frances, Dawn, Jackie, Rapley, Llesley, Chadwick, Carmel, Chapman, Petra, Crone, Jonathan, Albrett, Peter, Marko, Jennifer, Goodson, Troy, Browne, Richard, Whitticase, Cheryl, Davidson, Harriet, Judd, Daniel, Owens, Tonia, Onyeka, Innocent, Ugwu, Rose, Ilesanmi, Prisca Olabisi Adejumo, Afolabi, Owojuyigbe, Anthony, Adenekan, Stella, Uba, Christiana, Chime, Deborah, Jibrin, Babangida John Sankey, Oyebola, Adekola, Simeon, Olanipekun, Mirjana, Shosolcheva, Vanja, Gievski, Andrijan, Kartalov, Filip, Naumovski, Biljana, Kuzmanovska, Angela, Trposak, Zaneta, Bogoevska-Miteva, Rodney, Rosalia, Brita Fosser Olsen, Britt, Sjobo, Karianne Dale Jensen, Drammen, Sykehus, Birgitte Fosser Johansen, Esben, Straede, Edda, Johansen, Inger Johanne Finnstrom, Annette, Toellefsen, Hege, Ostenjo, Hege, Bjorgen, Bjorn, Bratsberg, Elin, Kristoffersen, Elin Mari Skorstad, Siri, Hansen, Sylvi, Vullum, Gro Anne Lunde, Wenche, Arntsen, Mette, Lund, Gro Ringstad Akselsen, Kristina Reinertsen Monstad, Ane, Stenset, Hanne, Haugom, Bjoern, Monsen, Lisa, Høgvall, Siw, Trudvang, Britt, Galaaen, Siv Karin Malmin, Marit Hildegunn Andersen, Rita Foss Hargott, Yvonne, Andersen, Elin, Steffenak, Marit, Nyhus, Barbro, Meland, Madiha, Hashmi, Noelia, Rivas, Elizabeth, Maidana, Alberto de Jesús Ortiz, Dolly Mabel Bordon Cabral, Marcelo, Simi, Cesar, Aponte, Juan Carlos Rivas, Sirley, Gill, Amilcar, Garcia, Gloria, Alvarenga, Laura, Cespedes, Hugo, Perez, Maria Liz Moreira, Fidelina, Canete, Roberto, Gonzalez, Natalia, Monges, Mary, Coman, Marcelo, Pederzani, Natalia, Franco, Ferdinand, Aganon, Regina, Martinez, Debbie, Noblezada-Uy, Chris Gerome Ellazar, Franklin Dean Cerezo, Jose Emmanuel Palo, Cristal April Jane Aperocho, Michael, Isanan, Marta, Tubacka, Przemyslaw, Jasiewicz, Miroslaw, Czuczwar, Michal, Borys, Aleksandra, Gutysz-Wojnicka, Lidia, Glinka, Ryszard, Gawda, Jan, Bilawicz, Paula, Cabrita, João, Vieira, Margarida Ferreira Figueiredo, Cristiana Mota Pinheiro, Nelson, Antunes, Laura, Pedro, Fatima, Ferreira, Isabel, Parente, Maria, Varela, Fatima, Fernandes, Claudia, Martins, Abel, Viveiros, Raquel, Cavaco, Clara Santa Rita, Sofia, Dias, Ana Margarida Feranandes, Pedro, Silva, Catarina, Nunes, João, Cabral, Filpe, Pires, Hilaryano, Ferreira, Jacinta, Santos, Vitor Manuel Vaz Pinto, Bruno Miguel Bispo, Amelia, Ferreira, Elena, Molinos, Estevão, Lafuente, Ricardo, Gregorio, Humberto, Costa, Ângela, Lima, Susana, Ferreira, Vanda, Seromenho, Eulália, Luis, Idália, Valerio, Helena, Cesar, Ana, Tavares, Ahmed Subhy Alsheikhly, Saeed, Mahmood, Catalin Traian Guran, Alida, Moise, Daniela Carmen Filipescu, Mihail, Luchian, Mihai, Popescu, Monica Adriana Scutariu, Cristina, Petrisor, Natalia, Hagau, Ioana, Grigoras, Tatiana, Patrichi, Vitaly, Gusarev, Alexandra, Pivkina, Vladimir, Kulakov, Olga, Ignatenko, Julia, Kovaleva, Trina, Zhivotneva, Marina, Zhedaeva, Nikita, Matiushkov, Olga, Ershova, Natalya, Egorova, Victoria, Khoronenko, Danil, Baskakov, Dmitry, Sergeev, Michael, Piradov, Liudmila, Grishina, Marat, Magomedov, Evgeniy, Zuev, Uri, Gorokhovatsky, Anna, Leonova, Liudmila, Fadeeva, Vladislav, Belskiy, Dmitriy, Galishevskiy, Nadezhda, Zubareva, Maksim, Tribulev, Oksana, Zueva, Alexander, Kiselev, Nikolaj, Kamenshchikov, Ekaterina, Tokareva, Maxim, Petrushin, Irina, Starchenko, Isaac, Nshimyumuremyi, Jerome, Muhizi, Egide, Buregeya, Josue, Nzarora, Amer, Assiri, Maie Salem Ebaid, Ghaleb, Almekhlafi, Yasser, Mandourah, Jelena, Velickovic, Dejan, Veličković, Bojan, Jovanovic, Adi, Hadzibegovic, Branislava, Stefanovic, Vanja, Misic, Vesna, Bumbasirevic, Marija, Rajković, Milena, Stojanovic, Srđan, Gavrilovic, Maja, Stanojević, Aktham, Yaghi, Anton, Turčan, Peter, Firment, Garri, Slobodianiuk, Daria, Rabarova, Danca, Lančaričová, Janko, Vlaovic, Matjaž, Groznik, Milica, Lukic, Janja, Perme, Maja, Sostaric, Nejc, Umek, Tomislav, Mirkovic, Simon, Dolenc, Misa, Fister, Nika, Zorko, Andrej, Markota, Nomhle Princess Yeni, Phumele, Jali, Shelley, Schmollgruber, Muhommed Ridwaan Syed, Nivisha, Parag, Robert, Wise, Maria, Galiana, José Alejandro Navarro, Ana María De Pablo, Patricia, Albert, Pilar, Martinez, Yolanda, Mendiara, Barbara, Garcia, Ana Alabart Llinas, Marilyn, Riveiro, Elisabet, Gallart, Alba, Riera, Miquel, Sanz, Swagotika, Salo, Miguel Angel Gimenez Lajara, Montserrat Venturas Nieto, Rosa, Garcia, José Manuel Garcia Pena, Maria Carmen Gorgolas, Maria Aranzazu Isasi, Rafael, Sierra, Federico, Gordo, Isabel, Conejo, Vicent, Salvà-Costa, Carolina, Garzón-Tovar, Sara, Lospitao, Rafael, Gonzalez, Pedro, Gutierrez, Mercè, Girona, Jordi, Adamuz, Pablo Garcia Olivares, José Peral Gutierrez de Ceballos, Celia, Tirado, Irene De Wit, Ana Belén Curto Polo, Maria Del Mar Diaz Salcedo, Javier, Ripolles-Melchor, Eugenio, Martinez-Hurtado, Jorge Duerto Alvarez, María Luisa Bravo Arcas, Juan Ignacio Torres Gonzalez, Ana Belén Sánchez de la Ventana, Pablo Lopez-Arcas Calleja, Raquel Garcia Alvarez, Purificacion Sanchez Zamora, Alvaro Ortega Guerrero, Rosario, Cosano, Jonathan, Perez-Vacas, Margarita, Campos-Perez, Emma Moreno Barreiro, Losune Cano Sanchez, Monica Garcia Diaz, Raquel, Jimenez, Lorena Del Rio Cabajo, Daniel Sancho Muriel, Helena Fernandez Alonso, Ana Wensell Fernández, Isabel Santín Piñan, Guillermo Muñiz Albaiceta, Maria Cristina Iglesias Fernandez, Francisco Javier Saenz Abos, Pablo, Monedero, Ramon Molina Chueca, Lydia Gallego Aguirre, Silvia Call Manosa, Carmen Partera Luque, Neus, Calpe, Monica Recio Losilla, Meritxell Tapia Fores, Olga, Farre, Oscar, Fernandez, M Del Rosario Villar Redondo, Donaldo, S Arteta Arteta, Maria Angeles Hurtado Sanchez, Cristina Paños Espinosa, Laura Martinez Reyes, Laura Claramunt Domenech, Carmen Velasco Guillén, Josep Trenado Alvarez, Mercedes Del Cotillo, Jesus Emilio Barrueco-Francioni, Belen Burgos Conde, Maria Pilar Sogues Blanco, Maria Luisa Blasco, Ana Isabel Clement, Clara, Hurtado, Luz Coronado Sanz, David, Perez-Torres, Estefanía, Prol-Silva, Jorge, Pereira, Iván Areán González, Anastasio Espejo Cano, Cesar Rodriguez Nuñez, Inmaculada Lorenzo Fernadez, Alejandra Azahara Marguello Fernandez, Rosa Del Bosque Diez, Badiola, Hilario, Begoña, Zalba-Etayo, Ana, Pascual-Bielsa, Preveen, Banwarie, Dick, Nahar, Alisha van Axel, Naraindath, N Boedjawan, Erika Backlund Jansson, Ann-Sofie, Malvemyr, Lotta, Johansson, Ulla, Sandberg, Catarina, Tingsvik, Gunilla, Mattsson, Gun, Löf, Martin, Spångfors, Mona, Ringdal, Sebastian, Geijer, Lotti, Orvelius, Mia, Hylen, Caroline, Lagerhäll, Eva, Åkerman, Viveca Hamback Hellkvist, Ulrica, Mickelsson, Ewa, Wahlbom, Ing-Marie, Larsson, Ewa, Wallin, Filippo, Boroli, Solenne, Ory, Margaret Lynn Jong, Alexander, Dullenkopf, Martin, Lang, Yvan, Fleury, Marianne, Maus, Nawfel, Ben-Hamouda, Anne, Fishman, Mei Yu Hsu, Shu Chuan Chang, Konlawij, Trongtratul, Chaiwut, Sawawiboon, Sunthiti, Morakul, Bodin, Khwannimit, Keevan, Singh, Dale, Ventour, Dianne, Figaro-Barclay, Sasha, Sankar-Maharaj, Mhamed Sami Mebazaa, Salma, Kamoun, Souheil, Elatrous, Lamia, Besbes, Fekri, Abroug, Walid, Naija, Youssef Zied Elhechmi, Walid, Sellami, Zied, Hajjej, Takoua, Merhabene, Imen, Talik, Ozlem Ozkan Kuscu, Ozcengiz, Dilek, Avşar, Zerman, Hayriye Cankar Dal, Sema, Turan, Semih, Aydemir, Hakan, Yilmaz, Duygu Kayar Calili, Seval, İzdes, Melike, Cengiz, Ayça, Gümüş, Banu, Taşdemir, Ali, Kağnıcı, Mustafa, Ay, Serap Avcı Ay, Gulbahar, Caliskan, Turkay, Akbas, Abidin Oner Balbay, Serdar, Efe, Volkan, Inal, Gülseren, Elay, Pınar, Karabacak, Boğaç, Özserezli, Evren, Şentürk, Oktay, Demirkiran, Suha, Bozbay, Elif, Erdogan, Mustafa, Akker, Nebia, Peker, Asu, Ozgultekin, Sibel Ocak Serin, Can, Turan, Gulsah, Karaoren, Senay, Goksu, Sait, Karakurt, Huseyin, Arikan, Fethi, Gül, İsmail, Cinel, Iskender, Kara, Hasan Nabi Undar, Yesim Serife Bayraktar, Jale Bengi Çelik, Murat Emre Tokur, Demet Tok Aydin, İsmail, Yildiz, Beysim, Özcan, Başar, Erdivanli, Ahmet, Eroglu, Devrim, Akdağ, Nurdan, Ünlü, Adonis, Dungca, Ashwaq, Ali, Bindu, Thankamma, Paul Eric Reyes, Sini, John, Ajitha, Rajendran, Fatima Kasem El Ahmad, Kathleen Ann Smiley, Susanna, Hojden, Mia Thorning Miller, Vishnu Das Sasidharan Nair, Maria Gracia San Antonio, Khaled Al Qawasmeh, Sabah Abu Shawish, Hilary, Twiggs, Ines, Rosado, Volodymyr, Babych, Faye, Morren, Charlotte, Young, Nicola, Vaughan-Jones, Stephanie, Harris, Karen, Burns, Carmel, Georgiev, Rosina, Shayamano, Ian, Kerslake, Peter, Creber, Ana, Vochin, Catherine, O'Brien, Paul, Caddell, Samantha, Hagan, Mandy, Hughes, Tomasz, Torlinski, James, Sherwin, Santhana, Kannan, Amber, Markham, Richard, Lebon, Jason, Cupitt, Julius, Cranshaw, Nigel, White, Victoria, Marriott, Wendy, Milner, Casiano Barrera Groba, Joao, Azoia, Petra, Polgarova, Shaly, George, Ritoo, Kapoor, Ceri, Lynch, Nathalie, Fox, Karen, Cranmer, Natalie, Fox, Thomas, Llewellym, Kelly, Matthews, Louise, Maltby, Jowena, Ibao, Karen, Boulton, Rachel, Jarman, Karen, Baxter, Ashok Sundai Raj, Arif, Moghal, Joanne, White, Suzanne, Barrowcliffe, Mark, Pulletz, Vaarisan, Ganeshalingam, Rosaleen, Baruah, Carole, Boulanger, Helen, Baker, Justin, Woods, Poe Poe Ei, Vongayi, Ogbeide, Paul, Hayden, Jennifer, Hughes, Madhu, Balasubramanian, Armorel, Salberg, Rajnish, Saha, Dagmar, Holmquist, Claire, Derbyshire, Neil, Smith, Elizabeth, Stones, Jane, Ademokun, Monica, Popescu, Maria Schofield Legorburo, Samantha, North, Carole, Brett, Helen, Jaundoo, Jayne, Craig, Simon, Whiteley, Clare, Howcroft, Liz, Wilby, Peter, Delve, David, Shaw, Karen, Williams, Ingeborg, D Welters, Jane, Mcmullen, Stephen, Brett, Leah, Flores, Treiza, Trueman-Dawkins, Mae, Templeton, John, Adams, Catherine, Smith, John, Prowle, Heather, Byers, Andrea, Mcdonnell, Bernd Oliver Rose, Rosie, Reece-Anthony, Luis, Mendes, Marcela, Vizcaychipi, Rhian, Bull, Grace, Lacaden, Eleanor, Santiago, Carlos Castro Delgado, Sarah, Farnell-Ward, Elaine, Thorpe, Justine, Somerville, Anne, Williams, Donna, Cummings, Helen, Derrick, Sarah, Brumwell, Claire, Randell, Nicola, Mccann, Emma, Aves, Gillian, Berry, Tamas, Szakmany, Una, Gunter, Paul, Pulak, Nikki, Sarkar, Kerry, Wright, Vitor, Gomes, Jones, Jo, Ruth, Palfrey, Julie, Camsooksai, Abby, Lewis, Antony, Eneas, Ascanio, Tridente, Louise, Barr, Beverley, Thomas, Emma, Parkin, Daniel, Horner, Christian, Frey, Suzanne, Bench, Rachel, Baumber, Phil, Broadhurst, Matthew, Jackson, Lynne, Williams, Michele, Clark, Jonathan, Paddle, Sarah, Bean, Sarah, Buckley, Christopher, Palfreeman, Sophie, Liu, Nicola, Allison, Ben, Attwood, Penny, Parsons, Victoria, Houghton, Sarah Jane Turner, David, Higgins, Egidija, Bielskute, Nicola, Horrigan, Reni, Jacob, Karen, Habgood, Ahmed, Zaki, Amy, Collins, Jenny, Lord, Charalice, Ramiro, Agnieszka, Kubisz-Pudelko, Michelle, Kotze, Helen, Williams, Ihor, Iovenko, Alexander, Tsarev, Arturo, Briva, Gabriela, Mendez, Lena, Napolitano, Magnus, Teig, Jarone, Lee, Gabriel Enrique Rodriguez, Talia, Ben-Jacob, Christopher, Potestio, Timothy, Eng, Dea, Mahanes, Ashish, Khanna, Abhijit, Duggal, Masakatsu, Nananmori, Manuel, Lois, Anna, Diaz, Kunal, Karamchandani, Cheryl, Bealer, Cindy, Barefield, Dorothy, Terry, Pauline, Fivecoat, Olakunle, Idowu, Juan, Cata, Tara, Clesi, Jessica, Peterson, Kevin, Hatton, Jasdeep, Dhaliwal, Dorothee, Mueller, Jing, Tao, Ashley Szabo Eltorai, Stephen, M Pastores, Natalie, Remor, Janel, Salazar, Diane, Barkas, Aaron, Joffe, Christopher, Barnes, Carrie, Sona, Marilyn, Schallom, Jack, Short, Javier, Lorenzo, Ingrid Von Der Osten, Marta, Borkowska, Mireia, Llaurado-Serra, Liesbet, Demarré, Vincianne, Pleitinckx, Cynthia, Xing, Anne-Sophie, Debue, Stefan, Goller, Elsa, Afonso, Gusarov, V, Eugeniya, Larina, Llaurado-Serra, M, Yalim, Dikmen, DecubICUs Study Team, European Society of Intensive Care Medicine (ESICM) Trials Group Collaborators, Muzha, D., Ribas, A.M., Lipovesty, F., Loudet, C., Coyer, F., Eller, P., Mostafa, N., Honoré, P.M., Telleria, V.M., Smajic, J., Nogueira, P.C., Nafees, KMK, Hentchoya, R., Rose, L., Soledad, J., Lin, F., Cardenas, Y., Reyes, A.G., Sustic, A., Mpouzika, M., Vymazal, T., Jensen, H.I., Aguirre-Bermeo, H., Maddison, L., Valta, M., Calvino-Gunther, S., Bloos, F., Adipa, F.E., Koulouras, V., Enamorado, J., Ágoston, Z., Birgisdóttir, H., Gupta, A., Gurjar, M., Kilapong, B., Hashemian, S.M., Martin-Loeches, I., Benbenishty, J., Cortegiani, A., Fletcher, K., Hayashi, Y., Waweru-Siika, W., Abidi, K., Lee, S.M., Hadri, B., Dolgusevs, M., Abillama, F.F., Jovaisa, T., Thix, C., Elhadi, M., Nor, B.M., Ratnam, S., Mazlan, M.Z., Maiyalagan, S., Sánchez-Hurtado, L., Belii, A., Naranpurev, M., Gautam, P., De Lange, D., Parke, R., Ilesanmi, R.E., Shosholcheva, M., Petosic, A., Lind, R., Ffarcsi, M.H., Bogarin, J., Hernandez, A.M., Mikaszewska-Sokolewicz, M., Sousa, B., Tomescu, D., Sandesc, D., Twagirumugabe, T., Gusarov, V., Ebaid, M., Jankovic, R., Slobodianiuk, G., Martonova, A., Knafelj, R., Mer, M., Maseda, E., Panka, B., Schefold, J.C., Joelsson-Alm, E., Trongtrakul, K., Merritt-Charles, L., Besbes, L.O., Dikmen, Y., Zgrzheblovska, L., Fielding, M., Rubulotta, F., Khanna, A.K., Saager, L., von der Osten, I., Greca, A., Cani, A., Xhindi, N., Hyska, G., Pinto, S., Alves, P., Esposito, R., Valgolio, E., Minope, JTS, Abdala, A., Ayala, M., Bravo, S., Bantar, A., Delgado, P., Badariotti, G., Lipovestky, F., Diaz, A., Saul, P., Setten, M., Aucapina, A., Acosta, Y., Gonzalez, V., Camputaro, L., Baccaro, F., Villa, R., Mastantuono, M., Dean, E., Rostello, O.F., Brizuela, P., Bartoli, J.R., Guereschi, M., Quiroga, C., Putruele, S., Villegas, P., Curilen, V., Fernandez, R., Nocheretti, M.G., Escalante, R.G., Loudet, C.I., Fernandez, S., Gonzalez, A.L., Alvarez, G.A., Iglesias, F., Chaparro, S., Zakalik, G., Pagella, G., Baini, M., Campos, P.A., Sabbag, I., Schmukler, A., Fonseca, I.P., Alvarez, G.M., Ramirez, M., Tapia, F., Bascary, C.A., Del Valle Gimenez, G., Bertoletti, F.P., Milioto, E., Bonsignore, PJM, Fernandez, M.A., Smith, J., Chimunda, T., Thompson, L., Maguire, T., Chaboyer, W., Watts, S., Mitchell, M., Powell, M., Lye, I., Parsons, L., Baker, N., Reynolds, C., Thompson, A., Masters, K., Sosnowski, K., Morrison, L., Leslie, G.D., Lakshmanan, R., Tabah, A., Brown, W., McDowell-Skaines, S., McLucas, A., Smith, C., Tallot, M., Jones, S., Barakat-Johnson, M., Leong, T., Butcher, R., Martin, K., Douschan, P., von Lewinski, D., Schmutz, R., Kolussi, U., Salman, F., Ateya, Z., De Decker, K., Van Regenmortel, N., Jans, A., Wijnands, P., Coremans, S., Honore, P.M., De Bels, D., Depuydt, T., Paillet, C., Jacquet, L.M., Swinnen, W., Hannes, F., Mergeay, M., Van de Velde, S., Allaert, S., Hoste, P., Borin, C., Balon, S., Fraipont, V., Biston, P., De Schryver, N., Dugernier, T., Van Cotthem, I., de Almeida, A.O., Jorge, S.A., Becker, D., Schmidt, R.C., Oliveira, E., Ramalho, A., Mazocoli, E., Fioretti, A., Barros, E., Serpa, L., Bianchini, S., Campanili, T., Pantaleao, T., Garcia, P.C., Ronchini, ALV, Santos, R., Manap, NBA, Bagshaw, S., Carney, D., Davidow, J., Rokosh, E., Laizner, A.M., Smith, S., McQuirter, M., Kampayana, B.S., Favre, R., Sills, M., Dallaire, J., Becker, C., Microys, S., Bowes, B., Lajeunesse, J., Ghosh, R., Baptiste-Savoie, J., Raizman, R., Suen, G., Taghavi, N., Smith, O., Fielding, C., Canales, J., Molina, P., Chaparro, J., Sepulveda, M.I., Zamorano, MJF, Rocha, P., Villanueva, X., Araya, P., Dayan, M., Avalos, F., Li, X., Liu, Y., Chen, X., Jiang, Z., Yang, J., Chen, J., Yang, L., Wang, K., Gao, J., Fang, X., Zhao, R., Xia, X., Liu, H., Li, J., Wang, H., Meng, G., Di, Y., Wang, D., Zhao, R.H., Hu, L.P., Peipei, X., Jiao, Q.F., Wang, H.Y., Xia, C.J., Ye, M., Wan, Y., Wang, W., Ding, Y., Ren, A., Gao, Y., Li, Q., Du, G., Shen, Y., Li, N., Yuan, C., Tan, L., Lin, Q., Guo, H., Yan, H., Xu, X., Zhang, W., Liang, J., Zhang, L., Tian, E., Zhao, Q., InSu, L., Dong, J., Gu, Y., Zhao, L., Qiao, H., Tuo, L., Lv, M., Zhu, J.Y., Zhu, J., Wei, Y., Liu, M., He, Y., Cheng, J., Liu, J., Jia, N., Wei, D., Wu, X., Duan, H., Lin, D., Liang, Q., Luo, X., Xiong, Y., Huang, R.F., Fu, J., Zan, T., Shi, Z., Long, Y., Lei, Y., Liu, X., Yumei, C., Wang, L., Zhang, Y., Xu, Y., Cheng, X., Zhijuan, W., Sun, C., Song, J., Wang, Y., Yuan, Y., Huang, Q., Yang, F., Wu, Y., Bai, X., Zheng, H., Song, M., Sun, Y., Li, Z., Luo, F., Li, L.C., Zhang, G., Xiao, L., Yu, T., Gao, G., Wei, W., Wang, F., Han, T., Li, T., Zeng, Q., Zeng, J.M., Pan, F., Wang, J., He, G., Chen, H., Zhang, F., Chao, Y., Chunhua, G., Yao, X., Bai, D., Liu, L., Liang, X., Zhang, N., Zhang, A., Hu, X., Zhang, H., Wang, R., Tak, P.S., Ho, S.W., Jiang, Q.X., Ding, X., Hong, L., Miao, L., Feng, Z., Huang, L., Wu, J., Guo, J., Zhang, B., Ma, C., Han, Y., Liu, C., Ding, M., Luan, L., Zheng, J., Lv, S., Jiang, S., Cao, W., Xue, X., Liu, G., Wei, X., Jiang, Y., Yao, Z., Gao, L., Zhao, W., Jiang, M., Hao, J., Zhang, J., Song, C., Chen, F., Wang, S., Hu, L., Cao, D., Wan, J., Wang, X., Shao, H., Zhang, Z., Cui, X., Fan, L., Yu, M., Li, B., Li, C., Chen, W., Li, Y., Zhigang, Z., Yuchen, W., Mu, C., Zhu, G., Bo, Q., Li, L., Chen, M., Jiang, J.H., Yin, H., Pang, X., Gong, Y.Y., Yang, S., Yan, X., Zheng, X., Lei, D., Lei, L., Guo, Y., Yu, J., Sun, W., Bi, A., Li, W., Ni, D., Wu, Z., Song, B., Fei, Q., Xiaoyan, Y., Ran, Q., Xixi, L., Jiao, X., Ji, H., Zhiping, S., Hong, M., Jianhong, M., Hao, Y., Yin, L., Hui, C., Ju, W., Huo, Y., Chen, L., Yan, Y., Bao, G., Cao, Y., Xu, L., Guixiang, J., Zhao, H.M., Huang, X., Dai, Z., Jian, Y., Tian, Z., Cao, Z.Q., Li, M., Ouyang, F., Ma, F., Jin, W., Ge, L., Wu, S., Yuan, W., Chen, T., Shi, G., Chen, Z., Liu, K., Lin, X., Yuemen, L., Lijuan, S., Tian, X.F., Dong, Y., Bocui, N., Wang, G., Zhao, Y., Yang, Q., Hu, R.L., Li, X.Q., Yu, Z.J., Yao, Y., Deng, X., Xiao, Y., Xie, Y., Yang, Y., Yang, H., Zhou, Y., Xiao, M., Tian, Y., Gama, LMS, Hernandez, J.S., Caicedo, N., Marin, J., Ochoa, M.E., Gomez, M., Rojas-Suarez, J., Gonzalez, J., Reyes, AJG, Chapeta, E., Orozco, E., Filipović-Grčić, I., Vuković, A., Pečenković, S., Šuput, A., Zivanovic-Posilovic, G., Bozena, A., Udiljak, N., Milic, M., Radivojevic, R.C., Mihaljevic, S., Matas, M., Tonkovic, D., Čuljak, H., Herceg, I., Pavlisa, G., Dobric, M., Beker, T., Adam, V.N., Goranovic, T., Markoulias, C., Mathaios, M., Mylordou, M., Achilleos, E., Kleanthous, P., Kotanidi, V., Foka, M., Charalabous, I., Alexandrou, A., Georgiou, M., Patsalos, A., Zepoy, S., Constantinou, C., Piza, P., Wiborg, E., Bruhn, L., Kaasby, K., Pedersen, K.R., Mikkelsen, S., Collet, M., Langvad, A., Andresen, H., Fischer, S., Kjærgård, I.E., Jepsen, B., Husted, B., Bestle, M., Kodal, A.M., Hansen, TCB, Pedersen, ASB, Thomsen, T.D., Hoegenhaven, A., From, M., Frandsen, T.M., Henning, G., Hansen, A., Bliksted, I.A., Tamayo, L.M., Mogrovejo, P., Palaez, C., Tutillo, DRM, Hurtado, C.V., García, M.F., Alvarez, D., Guerrero, F., Vasquez, A., Kütimets, M., Tamme, K., Anvelt, E., Dlamini-Sserumaga, L., Löfqvist, C., Lusenius, V., Kauppi, O., Sakki, J.K., Tervo-Heikkinen, T., Kesti, U., Merilainen, M., Karjula, E., Peltomaa, M., Palmu, A., Ahtiala, M., Valta, M.A., Mentec, H., Plantefève, G., Besch, G., Pili-Floury, S., Ledochowski, S., Déserts, MDD, Giacardi, C., Daubin, C., Massard, A., Le Guen, Y., Blanc, A., Mandaroux, S., Günther, S.C., Avogadro, P., Radavidson, A., Turc, J., Jochmans, S., Quintard, H., Boyer, L., Bruel, C., Philippart, F., Montravers, P., Atchade, E., Flessel, N., Chinardet, B., Soulisse, L., Pillard, C., Ngo, D., Bongiorno, B., Heitzler, N., Souppart, V., Gautheret, N., Timsit, J.F., Essardy, F., Fartoukh, M., Mehay, D., Etourneau, F., Farkas, J.C., Beuret, P., Preda, G., De Montmollin, E., Castelain, V., Jaschinski, U., Rothenfusser, M., Kindgen-Milles, D., Dimski, T., Fiedler, C., Heinicke, T., Meybohm, P., Schulze, T., Bota, M., Pelz, S., Odenthal, T., Christ, M., Bösl, K., Chovas, A., Stehr, S., Simon, P., Grotheer, S., Schüppel, S., Schaller, S., Albrecht, L., Stübner, A., Graeser, S., Kolbe, N., Lausch, M., Diers, A., Guenther, U., Riessen, R., Roller, M., Osei, I.P., Kusi-Appiah, A.C., Yakubu, Y.H., Guadi-Gosh, B., Dragoumanis, C., Christofis, C., Kazakos, N., Bastani, S., Martinos, C., Bekos, V., Papanikolaou, M., Papavasilopoulou, T., Efthymiou, A., Chantziara, V., Kyriakoudi, A., Kakaras, N., Diakaki, C., Flevari, A., Nikolaou, C., Katerina, K., Avramopoulou, L., Tsikritsaki, K., Gkiokas, G., Pantiora, E., Katsenos, C., Patsiou, E.C., Alexandropoulou, P., Koutsodimitropoulos, I., Farmakis, E., Nestora, K., Chatzis, M., Kondili, E., Soundoulounaki, S., Mousafiri, O., Lepida, D., Liarmakopoulou, A., Papathanakos, G., Oikonomou, M., Ioannides, P., Papadopoulos, D., Staikos, I., Stafylaraki, M., Raitsiou, B., Mandis, K., Ravani, I., Kourelea, S., Efthimiou, A., Thoma, G., Bakas, A., Psarulis, K., Anisoglou, S., Papageorgiou, E., Michailidou, E., Tholioti, T., Lavrentieva, A., Sourla, E., Spyropoulou, A., Pantelas, N., Stalika, KMM, Georgakas, I., Karathanou, A., Tsikriki, S., Dimoula, A., Kanakaki, S., Vakalos, A., Pagioulas, K., Enamorado, J.E., Nardai, G., Hawchar, F., Blondal, A., Rygvadottir, B., Jonasdottir, R.J., Birgisdottir, H., Shah, B., Kaushik, S., Tripathy, S., Singh, M., Agarwal, S., Gupta, M., Ahmad, M., Mangal, K., Bhargava, V., Kushare, V., Jha, S., Bhakhtiani, L., Kamal, M., Baronia, A., Susanti, A., Lestari, M.I., Zulkifli, Z., Baskoro, W., Zand, F., Zarei, F., Mahmoodpoor, A., Heidari, F., Jafaraghaee, F., O'Shea, A., O'Shea, F., O'Donnell, C., Craig, G., Fitzpatrick, G., Dunne, L., Hastings, J., Marsh, B., Cody, C., Campbell, E., Doyle, D., Pacturanan, M., Sheehan, C., Carey, A., Carter, C., Mulvey, R., Finn, DOR, Motherway, C., Walsh, A., Kehoe, J., Delossantos, S., Lalor, J., O'Nuallain, S., Behan, H., McPherson, S., Corcoran, A., Gordon, P., Rooney, G., Levy, D., Azencot, M., Gurevich, V., Lavy, A., Bendelari, V., Marconi, R., Barone, A., Gatti, C., Giampaoletti, A., Borgognoni, C., Ghioldi, D.M., Raimondo, A., Castiglione, G., Bruno, A.V., Rubulotta, G., Mo, A., Corso, A., Girianni, S., Bruni, A., Garofalo, E., Maggiore, S.M., Di Risio, A., Calamai, I., Spina, R., Spadaro, S., Volta, C.A., Cotoia, A., Mirabella, L., Maulicino, L., Abregal, G., Donvito, M., D'Ambrosio, P., Binda, F., Adamina, I., Galazzi, A., Negro, A., Vaschetto, R., Capuzzi, F., Boschetto, M., Stivanello, L., Bonaccorso, L., Megna, C., Iozzo, P., Rizzo, A., Scire, G., Taibi, M.R., Tranello, F.P., Manzo, A., Traina, L., Pastore, B., Quaini, A., Giusti, G.D., Montaldi, G., Piergentili, F., Mancini, F., Casaioli, S., Uccelli, F., Guarracino, F., Onelli, A., Di Gravio, V., Cossu, M., Matrona, O., Rocco, M., Alampi, D., Dellafiore, F., Ranalli, F., Bossolasco, M., Brizio, E., Migliorino, P., Cortellazi, P., Rosati, M., D'Ambrosio, F., Quagliotto, C., Roman-Pognuz, E., Peratoner, A., De Rosa, S., Martin, M.A., De Sanctis, F., Ciorba, P., Toppin, P., Harding-Goldson, H., Taito, S., Shime, N., Yamamoto, R., Kanda, F., Hirao, A., Egi, M., Noguchi, A., Hashimoto, S., Aya, U., Sakuramoto, H., Ohuchi, A., Kataoka, J., Maruyama, K., Nakayama, I., Nishime, Y., Fujimoto, K., Takahashi, K., Tsujimoto, M., Shimizu, M., Tole, E., Correia, M.C., Kim, J.H., Park, S., Kim, K.C., Baek, J., Bae, J.M., Park, S.Y., Park, T.S., Lee, H.B., Park, J., Yeon-Joo, L., Young-Jae, C., Jeon, K., Kim, S.C., Lee, J., Chee, H.K., Huh, J.W., Sim, Y.S., Kim, J., Chang, Y., Ahn, J.J., Kang, B.J., Lee, W.Y., Lee, S.J., Baftiu, N., Krastins, I., Stiban, S., Feghaly, M.E., Gharios, E., Merheb, M., Benlamin, M., Khaled, A., Belkhair, W.A., Tabib, M., Ashour, F., Elhadi, A., Tababa, OWE, Khaled, T., Alkhumsi, SIR, Alshrif, A.I., Aboufray, A.A., Alabuzidi, A., Triki, A.R., Elgammudi, M., Zahra, H.B., Soula, E., Al-Alawi, MMS, Ahmed, H., Ghula, MAA, Vosylius, S., Mouton, L., Rastegar, T., Sertznig, C., Martin, G., Theisen, C., Ferretti, C., Gils, F., Gallion, M., Zainudin, A., Bahrin, LKK, Deva, S.R., Rahim, AHA, Wahab, S., Hassan, WNW, Ismail, WNW, Ali, M.N., Khoo, T.M., Samat, N.M., Tong, JMG, Adib, NAN, Nor, MBM, Ismail, N., Sulaiman, S.R., Foong, K.W., Alias, A., Hua, N.P., Zermeno, J.M., Blanco, D., Duran, K., Nava, CLL, Nandyelly, SJR, Sanchez-Hurtado, L.A., Tejeda-Huezo, B., Del Moral Armengol, M., Nava, LPA, Herrera, J.G., de Anda, GFV, Gallegos-Perez, H., Hernandez-Sanchez, N., Hernandez-Ponce, L., Gorordo-Delsol, L., Hernandez-Romero, M., Gomez, S., Molinar, F., Ñamendys-Silva, S.A., Romero-Gonzalez, J.P., Gonzalez, D., Landaverde, A., Sosa, M.Á., Navarro, B., de Molina Serrano, JIR, Iburrigarro, S.R., Ibarra, A., Aguirre, J., Martinez-Gonzalez, M., Padilla, NRC, Pineda, AAV, Villafuerte, MVE, Herrera, MOG, Baasanjav, B., Hachimi, A., Elkhayari, M., Dendane, T., Subedi, N.B., Pathak, S.D., Manandhar, M., Van Gulik, L., Van Den Brink, M., Van Vliet, P., Gerretsen, B., Van Den Berg, L., De Haan, M., Tuinstra, B., Kuijpers, P., Reijntjens, J., Vermeijden, J.W., Rinket, M., Vanroest, M., Reidinga, A., Loef, B., Dieperink, W., Onrust, M., Dormans, T., Bormans, L., Koopmans, M., Gerritsen, R.T., Van Den Elst, A., Evers, M., Oiting, O., Wilting, R., Ramaker, B., van der Kuil, M., Fijen, J.W., Haas, L., Haringman, J., Newby, L., Gilder, E., Hacking, D., Dagooc, R., Song, R., Waibel, H., Dawn, F., Rapley, J., Chadwick, L., Chapman, C., Crone, P., Albrett, J., Marko, P., Goodson, J., Browne, T., Whitticase, R., Davidson, C., Judd, H., Owens, D., Onyeka, T., Ugwu, I., Ilesanmi, R., Adejumo, P.O., Owojuyigbe, A., Adenekan, A., Uba, S., Chime, C., Jibrin, D., Sankey, B.J., Adekola, O., Olanipekun, S., Shosolcheva, M., Gievski, V., Kartalov, A., Naumovski, F., Kuzmanovska, B., Trposak, A., Bogoevska-Miteva, Z., Rosalia, R., Olsen, B.F., Sjobo, B., Jensen, K.D., Sykehus, D., Johansen, B.F., Straede, E., Johansen, E., Finnstrom, I.J., Toellefsen, A., Ostenjo, H., Bjorgen, H., Bratsberg, B., Kristoffersen, E., Skorstad, E.M., Hansen, S., Vullum, S., Lunde, G.A., Arntsen, W., Lund, M., Akselsen, G.R., Monstad, K.R., Stenset, A., Haugom, H., Monsen, B., Høgvall, L., Trudvang, S., Galaaen, B., Malmin, S.K., Andersen, M.H., Hargott, R.F., Andersen, Y., Steffenak, E., Nyhus, M., Meland, B., Hashmi, M., Rivas, N., Maidana, E., de Jesús Ortiz, A., Cabral, DMB, Simi, M., Aponte, C., Rivas, J.C., Gill, S., Garcia, A., Alvarenga, G., Cespedes, L., Perez, H., Moreira, M.L., Canete, F., Gonzalez, R., Monges, N., Coman, M., Pederzani, M., Franco, N., Aganon, F., Martinez, R., Noblezada-Uy, D., Ellazar, C.G., Cerezo, F.D., Palo, J.E., Aperocho, CAJ, Isanan, M., Tubacka, M., Jasiewicz, P., Czuczwar, M., Borys, M., Gutysz-Wojnicka, A., Glinka, L., Gawda, R., Bilawicz, J., Cabrita, P., Vieira, J., Figueiredo, M.F., Pinheiro, C.M., Antunes, N., Pedro, L., Ferreira, F., Parente, I., Varela, M., Fernandes, F., Martins, C., Viveiros, A., Cavaco, R., Rita, C.S., Dias, S., Feranandes, A.M., Silva, P., Nunes, C., Cabral, J., Pires, F., Ferreira, H., Santos, J., Pinto, VMV, Bispo, B.M., Ferreira, A., Molinos, E., Lafuente, E., Gregorio, R., Costa, H., Lima, Â., Ferreira, S., Seromenho, V., Luis, E., Valerio, I., Cesar, H., Tavares, A., Alsheikhly, A.S., Mahmood, S., Guran, C.T., Moise, A., Filipescu, D.C., Luchian, M., Popescu, M., Scutariu, M.A., Petrisor, C., Hagau, N., Grigoras, I., Patrichi, T., Gusarev, V., Pivkina, A., Kulakov, V., Ignatenko, O., Kovaleva, J., Zhivotneva, T., Zhedaeva, M., Matiushkov, N., Ershova, O., Egorova, N., Khoronenko, V., Baskakov, D., Sergeev, D., Piradov, M., Grishina, L., Magomedov, M., Zuev, E., Gorokhovatsky, U., Leonova, A., Fadeeva, L., Belskiy, V., Galishevskiy, D., Zubareva, N., Tribulev, M., Zueva, O., Kiselev, A., Kamenshchikov, N., Tokareva, E., Petrushin, M., Starchenko, I., Nshimyumuremyi, I., Muhizi, J., Buregeya, E., Nzarora, J., Assiri, A., Ebaid, M.S., Almekhlafi, G., Mandourah, Y., Velickovic, J., Veličković, D., Jovanovic, B., Hadzibegovic, A., Stefanovic, B., Misic, V., Bumbasirevic, V., Rajković, M., Stojanovic, M., Gavrilovic, S., Stanojević, M., Yaghi, A., Turčan, A., Firment, P., Rabarova, D., Lančaričová, D., Vlaovic, J., Groznik, M., Lukic, M., Perme, J., Sostaric, M., Umek, N., Mirkovic, T., Dolenc, S., Fister, M., Zorko, N., Markota, A., Yeni, N.P., Jali, P., Schmollgruber, S., Syed, M.R., Parag, N., Wise, R., Galiana, M., Navarro, J.A., De Pablo, A.M., Albert, P., Martinez, P., Mendiara, Y., Garcia, B., Llinas, A.A., Riveiro, M., Gallart, E., Riera, A., Sanz, M., Salo, S., Lajara, MAG, Nieto, M.V., Garcia, R., Pena, JMG, Gorgolas, M.C., Isasi, M.A., Sierra, R., Gordo, F., Conejo, I., Salvà-Costa, V., Garzón-Tovar, C., Lospitao, S., Gutierrez, P., Girona, M., Adamuz, J., Olivares, P.G., de Ceballos, JPG, Tirado, C., De Wit, I., Polo, ABC, Del Mar Diaz Salcedo, M., Ripolles-Melchor, J., Martinez-Hurtado, E., Alvarez, J.D., Arcas, MLB, Gonzalez, JIT, de la Ventana, ABS, Calleja, P.L., Alvarez, R.G., Zamora, P.S., Guerrero, A.O., Cosano, R., Perez-Vacas, J., Campos-Perez, M., Barreiro, E.M., Sanchez, L.C., Diaz, M.G., Jimenez, R., Del Rio Cabajo, L., Muriel, D.S., Alonso, H.F., Fernández, A.W., Piñan, I.S., Albaiceta, G.M., Fernandez, MCI, Abos, FJS, Monedero, P., Chueca, R.M., Aguirre, L.G., Manosa, S.C., Luque, C.P., Calpe, N., Losilla, M.R., Fores, M.T., Farre, O., Fernandez, O., Del Rosario Villar Redondo, M., Arteta Arteta, D.S., Sanchez, MAH, Espinosa, C.P., Reyes, L.M., Domenech, L.C., Guillén, C.V., Alvarez, J.T., Del Cotillo, M., Barrueco-Francioni, J.E., Conde, B.B., Blanco, MPS, Blasco, M.L., Clement, A.I., Hurtado, C., Sanz, L.C., Perez-Torres, D., Prol-Silva, E., Pereira, J., González, I.A., Cano, A.E., Nuñez, C.R., Fernadez, I.L., Fernandez, AAM, Del Bosque Diez, R., Hilario, B., Zalba-Etayo, B., Pascual-Bielsa, A., Banwarie, P., Nahar, D., van Axel, A., Boedjawan, N.N., Jansson, E.B., Malvemyr, A.S., Johansson, L., Sandberg, U., Tingsvik, C., Mattsson, G., Löf, G., Spångfors, M., Ringdal, M., Geijer, S., Orvelius, L., Hylen, M., Lagerhäll, C., Åkerman, E., Hellkvist, V.H., Mickelsson, U., Wahlbom, E., Larsson, I.M., Wallin, E., Boroli, F., Ory, S., Jong, M.L., Dullenkopf, A., Lang, M., Fleury, Y., Maus, M., Ben-Hamouda, N., Fishman, A., Hsu, M.Y., Chang, S.C., Trongtratul, K., Sawawiboon, C., Morakul, S., Khwannimit, B., Singh, K., Ventour, D., Figaro-Barclay, D., Sankar-Maharaj, S., Mebazaa, M.S., Kamoun, S., Elatrous, S., Besbes, L., Abroug, F., Naija, W., Elhechmi, Y.Z., Sellami, W., Hajjej, Z., Merhabene, T., Talik, I., Kuscu, O.O., Dilek, O., Zerman, A., Dal, H.C., Turan, S., Aydemir, S., Yilmaz, H., Calili, D.K., İzdes, S., Cengiz, M., Gümüş, A., Taşdemir, B., Kağnıcı, A., Ay, M., Ay, S.A., Caliskan, G., Akbas, T., Balbay, A.O., Efe, S., Inal, V., Elay, G., Karabacak, P., Özserezli, B., Şentürk, E., Demirkiran, O., Bozbay, S., Erdogan, E., Akker, M., Peker, N., Ozgultekin, A., Serin, S.O., Turan, C., Karaoren, G., Goksu, S., Karakurt, S., Arikan, H., Gül, F., Cinel, İ., Kara, I., Undar, H.N., Bayraktar, Y.S., Çelik, J.B., Tokur, M.E., Aydin, D.T., Yildiz, İ., Özcan, B., Erdivanli, B., Eroglu, A., Akdağ, D., Ünlü, N., Dungca, A., Ali, A., Thankamma, B., Reyes, P.E., John, S., Rajendran, A., Ahmad, FKE, Smiley, K.A., Hojden, S., Miller, M.T., Das Sasidharan Nair, V., Antonio, MGS, Qawasmeh, K.A., Shawish, S.A., Twiggs, H., Rosado, I., Babych, V., Morren, F., Young, C., Vaughan-Jones, N., Harris, S., Burns, K., Georgiev, C., Shayamano, R., Kerslake, I., Creber, P., Vochin, A., O'Brien, C., Caddell, P., Hagan, S., Hughes, M., Torlinski, T., Sherwin, J., Kannan, S., Markham, A., Lebon, R., Cupitt, J., Cranshaw, J., White, N., Marriott, V., Milner, W., Groba, C.B., Azoia, J., Polgarova, P., George, S., Kapoor, R., Lynch, C., Fox, N., Cranmer, K., Llewellym, T., Matthews, K., Maltby, L., Ibao, J., Boulton, K., Jarman, R., Baxter, K., Raj, A.S., Moghal, A., White, J., Barrowcliffe, S., Pulletz, M., Ganeshalingam, V., Baruah, R., Boulanger, C., Baker, H., Woods, J., Ei, P.P., Ogbeide, V., Hayden, P., Hughes, J., Balasubramanian, M., Salberg, A., Saha, R., Holmquist, D., Derbyshire, C., Smith, N., Stones, E., Ademokun, J., Legorburo, M.S., North, S., Brett, C., Jaundoo, H., Craig, J., Whiteley, S., Howcroft, C., Wilby, L., Delve, P., Shaw, D., Williams, K., Welters, I.D., McMullen, J., Brett, S., Flores, L., Trueman-Dawkins, T., Templeton, M., Adams, J., Prowle, J., Byers, H., McDonnell, A., Rose, B.O., Reece-Anthony, R., Mendes, L., Vizcaychipi, M., Bull, R., Lacaden, G., Santiago, E., Delgado, C.C., Farnell-Ward, S., Thorpe, E., Somerville, J., Williams, A., Cummings, D., Derrick, H., Brumwell, S., Randell, C., McCann, N., Aves, E., Berry, G., Szakmany, T., Gunter, U., Pulak, P., Sarkar, N., Wright, K., Gomes, V., Jones, J., Palfrey, R., Camsooksai, J., Lewis, A., Eneas, A., Tridente, A., Barr, L., Thomas, B., Parkin, E., Horner, D., Frey, C., Bench, S., Baumber, R., Broadhurst, P., Jackson, M., Williams, L., Clark, M., Paddle, J., Bean, S., Buckley, S., Palfreeman, C., Liu, S., Allison, N., Attwood, B., Parsons, P., Houghton, V., Turner, S.J., Higgins, D., Bielskute, E., Horrigan, N., Jacob, R., Habgood, K., Zaki, A., Collins, A., Lord, J., Ramiro, C., Kubisz-Pudelko, A., Kotze, M., Williams, H., Iovenko, I., Tsarev, A., Briva, A., Mendez, G., Napolitano, L., Teig, M., Rodriguez, G.E., Ben-Jacob, T., Potestio, C., Eng, T., Mahanes, D., Khanna, A., Duggal, A., Nananmori, M., Lois, M., Karamchandani, K., Bealer, C., Barefield, C., Terry, D., Fivecoat, P., Idowu, O., Cata, J., Clesi, T., Peterson, J., Hatton, K., Dhaliwal, J., Mueller, D., Tao, J., Eltorai, A.S., Pastores, S.M., Remor, N., Salazar, J., Barkas, D., Joffe, A., Barnes, C., Sona, C., Schallom, M., Short, J., Lorenzo, J., Von Der Osten, I., Borkowska, M., Llaurado-Serra, M., Demarré, L., Pleitinckx, V., Xing, C., Debue, A.S., Goller, S., Afonso, E., Larina, E., Labeau, Sonia O. [0000-0003-3863-612X], Afonso, Elsa [0000-0003-0873-0852], Benbenishty, Julie [0000-0002-8488-9649], Blackwood, Bronagh [0000-0002-4583-5381], Boulanger, Carole [0000-0002-1392-6633], Brett, Stephen J. [0000-0003-4545-8413], Calvino-Gunther, Silvia [0000-0003-3586-7205], Chaboyer, Wendy [0000-0001-9528-7814], Coyer, Fiona [0000-0002-8467-0081], Deschepper, Mieke [0000-0001-6797-3147], Honore, Patrick M. [0000-0002-6697-4890], Jankovic, Radmilo [0000-0003-0742-8686], Khanna, Ashish K. [0000-0002-9083-891X], Llaurado-Serra, Mireia [0000-0002-5123-0581], Lin, Frances [0000-0001-8735-5469], Rose, Louise [0000-0003-1700-3972], Rubulotta, Francesca [0000-0001-8644-1728], Saager, Leif [0000-0003-3416-4727], Williams, Ged [0000-0002-7481-2445], Blot, Stijn I. [0000-0003-2145-0345], Apollo - University of Cambridge Repository, Critical Care, Labeau S.O., Afonso E., Benbenishty J., Blackwood B., Boulanger C., Brett S.J., Calvino-Gunther S., Chaboyer W., Coyer F., Deschepper M., Francois G., Honore P.M., Jankovic R., Khanna A.K., Llaurado-Serra M., Lin F., Rose L., Rubulotta F., Saager L., Williams G., Blot S.I., Muzha D., Ribas A.M., Lipovesty F., Loudet C., Eller P., Mostafa N., Telleria V.M., Smajic J., Nogueira P.C., Nafees K.M.K., Hentchoya R., Soledad J., Cardenas Y., Reyes A.G., Sustic A., Mpouzika M., Vymazal T., Jensen H.I., Aguirre-Bermeo H., Maddison L., Valta M., Bloos F., Adipa F.E., Koulouras V., Enamorado J., Agoston Z., Birgisdottir H., Gupta A., Gurjar M., Kilapong B., Hashemian S.M., Martin-Loeches I., Cortegiani A., Fletcher K., Hayashi Y., Waweru-Siika W., Abidi K., Lee S.-M., Hadri B., Dolgusevs M., Abillama F.F., Jovaisa T., Thix C., Elhadi M., Nor B.M., Ratnam S., Mazlan M.Z., Maiyalagan S., Sanchez-Hurtado L., Belii A., Naranpurev M., Gautam P., De lange D., Parke R., Ilesanmi R.E., Shosholcheva M., Petosic A., Lind R., Ffarcsi M.H., Bogarin J., Hernandez A.M., Mikaszewska-Sokolewicz M., Sousa B., Tomescu D., Sandesc D., Twagirumugabe T., Gusarov V., Ebaid M., Slobodianiuk G., Martonova A., Knafelj R., Mer M., Maseda E., Panka B., Schefold J.C., Joelsson-Alm E., Trongtrakul K., Merritt-Charles L., Besbes L.O., Dikmen Y., Zgrzheblovska L., Fielding M., von der Osten I., Greca A., Cani A., Xhindi N., Hyska G., Pinto S., Alves P., Esposito R., Valgolio E., Minope J.T.S., Abdala A., Ayala M., Bravo S., Bantar A., Delgado P., Badariotti G., Lipovestky F., Diaz A., Saul P., Setten M., Aucapina A., Acosta Y., Gonzalez V., Camputaro L., Baccaro F., Villa R., Mastantuono M., Dean E., Rostello O.F., Brizuela P., Bartoli J.R., Guereschi M., Quiroga C., Putruele S., Villegas P., Curilen V., Fernandez R., Nocheretti M.G., Escalante R.G., Loudet C.I., Fernandez S., Gonzalez A.L., Alvarez G.A., Iglesias F., Chaparro S., Zakalik G., Pagella G., Baini M., Campos P.A., Sabbag I., Schmukler A., Fonseca I.P., Alvarez G.M., Ramirez M., Tapia F., Bascary C.A., del Valle Gimenez G., Bertoletti F.P., Milioto E., Bonsignore P.J.M., Fernandez M.A., Smith J., Chimunda T., Thompson L., Maguire T., Watts S., Mitchell M., Powell M., Lye I., Parsons L., Baker N., Reynolds C., Thompson A., Masters K., Sosnowski K., Morrison L., Leslie G.D., Lakshmanan R., Tabah A., Brown W., McDowell-Skaines S., McLucas A., Smith C., Tallot M., Jones S., Barakat-Johnson M., Leong T., Butcher R., Martin K., Douschan P., von Lewinski D., Schmutz R., Kolussi U., Salman F., Ateya Z., De Decker K., Van Regenmortel N., Jans A., Wijnands P., Coremans S., De Bels D., Depuydt T., Paillet C., Jacquet L.-M., Swinnen W., Hannes F., Mergeay M., Van de Velde S., Allaert S., Hoste P., Borin C., Balon S., Fraipont V., Biston P., De Schryver N., Dugernier T., Van Cotthem I., de Almeida A.O., Jorge S.A., Becker D., Schmidt R.C., Oliveira E., Ramalho A., Mazocoli E., Fioretti A., Barros E., Serpa L., Bianchini S., Campanili T., Pantaleao T., Garcia P.C., Ronchini A.L.V., Santos R., Manap N.B.A., Bagshaw S., Carney D., Davidow J., Rokosh E., Laizner A.M., Smith S., McQuirter M., Kampayana B.S., Favre R., Sills M., Dallaire J., Becker C., Microys S., Bowes B., Lajeunesse J., Ghosh R., Baptiste-Savoie J., Raizman R., Suen G., Taghavi N., Smith O., Fielding C., Canales J., Molina P., Chaparro J., Sepulveda M.I., Zamorano M.J.F., Rocha P., Villanueva X., Araya P., Dayan M., Avalos F., Li X., Liu Y., Chen X., Jiang Z., Yang J., Chen J., Yang L., Wang K., Gao J., Fang X., Zhao R., Xia X., Liu H., Li J., Wang H., Meng G., Di Y., Wang D., Zhao R.H., Hu L.P., Peipei X., Jiao Q.F., Wang H.Y., Xia C.J., Ye M., Wan Y., Wang W., Ding Y., Ren A., Gao Y., Li Q., Du G., Shen Y., Li N., Yuan C., Tan L., Lin Q., Guo H., Yan H., Xu X., Zhang W., Liang J., Zhang L., Tian E., Zhao Q., InSu L., Dong J., Gu Y., Zhao L., Qiao H., Tuo L., Lv M., Zhu J.Y., Zhu J.F., Wei Y., Liu M., He Y., Cheng J., Liu J., Jia N., Wei D., Wu X., Duan H., Lin D., Liang Q., Luo X., Xiong Y., Huang R.F., Fu J., Zan T., Shi Z., Long Y., Lei Y., Liu X., Yumei C., Wang L.L., Zhang Y., Xu Y., Cheng, Zhijuan W., Sun C., Song J.H., Wang Y., Liu X.M., Yuan Y., Huang Q., Yang F., Wu Y., Bai X., Zheng H., Song M., Sun Y., Li Z.S., Luo F., Li L.C., Zhang G., Xiao L., Yu T., Gao G., Wei W., Wang F., Han T., Li T., Zeng Q., Zeng J.M., Pan F., Wang J., He G., Chen H., Zhang F., Chao Y., Chunhua G., Yao X., Bai D., Liu L., Liang X., Zhang N., Zhang A., Hu X.C., Zhang H., Wang R.X., Tak P.S., Ho S.W., Jiang Q.X., Ding X., Hong L., Miao L., Feng Z., Huang L.P., Wu J., Guo J., Zhang B., Ma C., Han Y., Liu C., Ding M., Luan L., Zheng J., Lv S., Jiang S., Cao W., Xue X., Liu G., Wei X., Jiang Y., Yao Z., Gao L., Zhao W., Jiang M., Hao J., Zhang J., Song C., Chen F., Wang S., Hu L., Cao D., Wan J., Wang X., Shao H., Zhang Z., Cui X., Fan L., Yu M., Li B., Li C., Liu X.L., Chen W., Li Y., Zhigang Z., Yuchen W., Mu C., Zhu G., Bo Q., Li L., Chen M., Jiang J.H., Yin H., Pang X., Gong Y.Y., Yang S., Yan X., Zheng X., Lei D.H., Lei L., Guo Y., Yu J., Sun W., Bi A.P., Li W., Ni D., Wu Z., Song B., Fei Q., Xiaoyan Y., Ran Q., Xixi L., Jiao X., Ji H., Zhiping S., Hong M., Jianhong M., Hao Y., Yin L., Hui C., Ju W., Huo Y., Chen L., Yan Y., Bao G., Cao Y., Xu L., Guixiang J., Zhao H.M., Huang X., Dai Z., Jian Y., Tian Z., Cao Z.Q., Li M., Ouyang F., Ma F., Jin W., Ge L., Wu S.F., Yuan W., Chen T., Shi G., Chen Z., Liu K., Lin X., Yuemen L., Lijuan S., Tian X.F., Feng Z.X., Liu X.Z., Dong Y., Bocui N., Jiang Z.X., Wang G.X., Zhao Y., Yang Q., Hu R.L., Li X.Q., Yu Z.J., Yao Y., Deng X., Xiao Y., Xie Y., Yang Y., Yang H., Zhou Y., Li Z., Xiao M., Yang Y.X., Tian Y., Gama L.M.S., Hernandez J.S., Caicedo N., Marin J., Ochoa M.-E., Gomez M., Rojas-Suarez J., Gonzalez J., Reyes A.J.G., Chapeta E., Orozco E., Filipovic-Grcic I., Vukovic A., Pecenkovic S., Suput A., Zivanovic-Posilovic G., Bozena A., Udiljak N., Milic M., Radivojevic R.C., Mihaljevic S., Matas M., Tonkovic D., Culjak H., Herceg I., Pavlisa G., Dobric M., Beker T., Adam V.N., Goranovic T., Markoulias C., Mathaios M., Mylordou M., Achilleos E., Kleanthous P., Kotanidi V., Foka M., Charalabous I., Alexandrou A., Georgiou M., Patsalos A., Zepoy S., Constantinou C., Piza P., Wiborg E., Bruhn L., Kaasby K., Pedersen K.R., Mikkelsen S., Collet M., Langvad A., Andresen H., Fischer S., Kjaergard I.E., Jepsen B., Husted B., Bestle M., Kodal A.M., Hansen T.C.B., Pedersen A.S.B., Thomsen T.D., Hoegenhaven A., From M., Frandsen T.M., Henning G., Hansen A., Bliksted I.A., Tamayo L.M., Mogrovejo P., Palaez C., Tutillo D.R.M., Hurtado C.V., Garcia M.F., Alvarez D., Guerrero F., Vasquez A., Kutimets M., Tamme K., Anvelt E., Dlamini-Sserumaga L., Lofqvist C., Lusenius V., Kauppi O., Sakki J.-K., Tervo-Heikkinen T., Kesti U., Merilainen M., Karjula E., Peltomaa M., Palmu A., Ahtiala M., Valta M.A., Mentec H., Plantefeve G., Besch G., Pili-Floury S., Ledochowski S., Deserts M.D., Giacardi C., Daubin C., Massard A., Le Guen Y., Blanc A., Mandaroux S., Gunther S.C., Avogadro P., Radavidson A., Turc J., Jochmans S., Quintard H., Boyer L., Bruel C., Philippart F., Montravers P., Atchade E., Flessel N., Chinardet B., Soulisse L., Pillard C., Ngo D., Bongiorno B., Heitzler N., Souppart V., Gautheret N., Timsit J.-F., Essardy F., Fartoukh M., Mehay D., Etourneau F., Farkas J.-C., Beuret P., Preda G., De Montmollin E., Castelain V., Jaschinski U., Rothenfusser M., Kindgen-Milles D., Dimski T., Fiedler C., Heinicke T., Meybohm P., Schulze T., Bota M., Pelz S., Odenthal T., Christ M., Bosl K., Chovas A., Stehr S., Simon P., Grotheer S., Schuppel S., Schaller S., Albrecht L., Stubner A., Graeser S., Kolbe N., Lausch M., Diers A., Guenther U., Riessen R., Roller M., Osei I.P., Kusi-Appiah A.-C., Yakubu Y.H., Guadi-Gosh B., Dragoumanis C., Christofis C., Kazakos N., Bastani S., Martinos C., Bekos V., Papanikolaou M., Papavasilopoulou T., Efthymiou A., Chantziara V., Kyriakoudi A., Kakaras N., Diakaki C., Flevari A., Nikolaou C., Katerina K., Avramopoulou L., Tsikritsaki K., Gkiokas G., Pantiora E., Katsenos C., Patsiou E.-C., Alexandropoulou P., Koutsodimitropoulos I., Farmakis E., Nestora K., Chatzis M., Kondili E., Soundoulounaki S., Mousafiri O., Lepida D., Liarmakopoulou A., Papathanakos G., Oikonomou M., Ioannides P., Papadopoulos D., Staikos I., Stafylaraki M., Raitsiou B., Mandis K., Ravani I., Kourelea S., Efthimiou A., Thoma G., Bakas A., Psarulis K., Anisoglou S., Papageorgiou E., Michailidou E., Tholioti T., Lavrentieva A., Sourla E., Spyropoulou A., Pantelas N., Stalika K.M.M., Georgakas I., Karathanou A., Tsikriki S., Dimoula A., Kanakaki S., Vakalos A., Pagioulas K., Enamorado J.E., Nardai G., Hawchar F., Blondal A., Rygvadottir B., Jonasdottir R.J., Shah B., Kaushik S., Tripathy S., Singh M., Agarwal S., Gupta M., Ahmad M., Mangal K., Bhargava V., Kushare V., Jha S., Bhakhtiani L., Kamal M., Baronia A., Susanti A., Lestari M.I., Zulkifli Z., Baskoro W., Zand F., Zarei F., Mahmoodpoor A., Heidari F., Jafaraghaee F., O'Shea A., O'Shea F., O'Donnell C., Craig G., Fitzpatrick G., Dunne L., Hastings J., Marsh B., Cody C., Campbell E., Doyle D., Pacturanan M., Sheehan C., Carey A., Carter C., Mulvey R., Finn D.O.C.R., Motherway C., Walsh A., Kehoe J., Delossantos S., Lalor J., O'Nuallain S., Behan H., McPherson S., Corcoran A., Gordon P., Rooney G., Levy D., Azencot M., Gurevich V., Lavy A., Bendelari V., Marconi R., Barone A., Gatti C., Giampaoletti A., Borgognoni C., Ghioldi D.M., Raimondo A., Castiglione G., Bruno A.V., Rubulotta G., Mo A., Corso A., Girianni S., Bruni A., Garofalo E., Maggiore S.M., Di Risio A., Calamai I., Spina R., Spadaro S., Volta C.A., Cotoia A., Mirabella L., Maulicino L., Abregal G., Donvito M., D'Ambrosio P., Binda F., Adamina I., Galazzi A., Negro A., Vaschetto R., Capuzzi F., Boschetto M., Stivanello L., Bonaccorso L., Megna C., Iozzo P., Rizzo A., Scire G., Taibi M.R., Tranello F.P., Manzo A., Traina L., Pastore B., Quaini A., Giusti G.D., Montaldi G., Piergentili F., Mancini F., Casaioli S., Uccelli F., Guarracino F., Onelli A., Di Gravio V., Cossu M., Matrona O., Rocco M., Alampi D., Dellafiore F., Ranalli F., Bossolasco M., Brizio E., Migliorino P., Cortellazi P., Rosati M., D'Ambrosio F., Quagliotto C., Roman-Pognuz E., Peratoner A., De Rosa S., Martin M.A., De Sanctis F., Ciorba P., Toppin P., Harding-Goldson H., Taito S., Shime N., Yamamoto R., Kanda F., Hirao A., Egi M., Noguchi A., Hashimoto S., Aya U., Sakuramoto H., Ohuchi A., Kataoka J., Maruyama K., Nakayama I., Nishime Y., Fujimoto K., Takahashi K., Tsujimoto M., Shimizu M., Tole E., Correia M.C., Kim J.H., Park S., Kim K.C., Baek J., Bae J.-M., Park S.Y., Park T.S., Lee H.B., Park J., Yeon-Joo L., Young-Jae C., Jeon K., Kim S.C., Lee J., Chee H.K., Huh J.W., Sim Y.S., Kim J., Chang Y., Ahn J.-J., Kang B.J., Lee W.-Y., Lee S.J., Baftiu N., Krastins I., Stiban S., Feghaly M.E., Gharios E., Merheb M., Benlamin M., Khaled A., Belkhair W.A., Tabib M., Ashour F., Elhadi A., Tababa O.W.E., Khaled T., Alkhumsi S.I.R., Alshrif A.I., Aboufray A.A., Alabuzidi A., Triki A.R., Elgammudi M., Zahra H.B., Soula E., Al-Alawi M.M.S., Ahmed H., Ghula M.A.A., Vosylius S., Mouton L., Rastegar T., Sertznig C., Martin G., Theisen C., Ferretti C., Gils F., Gallion M., Zainudin A., Bahrin L.K.K., Deva S.R., Rahim A.H.A., Wahab S., Hassan W.N.W., Ismail W.N.W., Ali M.N., Khoo T.M., Samat N.M., Tong J.M.G., Adib N.A.N., Nor M.B.M., Ismail N., Sulaiman S.R., Foong K.W., Alias A., Hua N.P., Zermeno J.M., Blanco D., Duran K., Nava C.L.L., Nandyelly S.J.R., Sanchez-Hurtado L.A., Tejeda-Huezo B., Del Moral Armengol M., Nava L.P.A., Herrera J.G., de Anda G.F.V., Gallegos-Perez H., Hernandez-Sanchez N., Hernandez-Ponce L., Gorordo-Delsol L., Hernandez-Romero M., Gomez S., Molinar F., Namendys-Silva S.A., Romero-Gonzalez J.P., Gonzalez D., Landaverde A., Sosa M.A., Navarro B., de Molina Serrano J.I.R., Iburrigarro S.R., Ibarra A., Aguirre J., Martinez-Gonzalez M., Padilla N.R.C., Pineda A.A.V., Villafuerte M.V.E., Herrera M.O.G., Baasanjav B., Hachimi A., Elkhayari M., Dendane T., Subedi N.B., Pathak S.D., Manandhar M., Van Gulik L., Van Den Brink M., Van Vliet P., Gerretsen B., Van Den Berg L., De Haan M., Tuinstra B., Kuijpers P., Reijntjens J., Vermeijden J.W., Rinket M., Vanroest M., Reidinga A., Loef B., Dieperink W., Onrust M., Dormans T., Bormans L., Koopmans M., Gerritsen R.T., Van Den Elst A., Evers M., Oiting O., Wilting R., Ramaker B., van der Kuil M., Fijen J.-W., Haas L., De Lange D., Haringman J., Newby L., Gilder E., Hacking D., Dagooc R., Song R., Waibel H., Dawn F., Rapley J., Chadwick L., Chapman C., Crone P., Albrett J., Marko P., Goodson J., Browne T., Whitticase R., Davidson C., Judd H., Owens D., Onyeka T., Ugwu I., Ilesanmi R., Adejumo P.O., Owojuyigbe A., Adenekan A., Uba S., Chime C., Jibrin D., Sankey B.J., Adekola O., Olanipekun S., Shosolcheva M., Gievski V., Kartalov A., Naumovski F., Kuzmanovska B., Trposak A., Bogoevska-Miteva Z., Rosalia R., Olsen B.F., Sjobo B., Jensen K.D., Sykehus D., Johansen B.F., Straede E., Johansen E., Finnstrom I.J., Toellefsen A., Ostenjo H., Bjorgen H., Bratsberg B., Kristoffersen E., Skorstad E.M., Hansen S., Vullum S., Lunde G.A., Arntsen W., Lund M., Akselsen G.R., Monstad K.R., Stenset A., Haugom H., Monsen B., Hogvall L., Trudvang S., Galaaen B., Malmin S.K., Andersen M.H., Hargott R.F., Andersen Y., Steffenak E., Nyhus M., Meland B., Hashmi M., Rivas N., Maidana E., de Jesus Ortiz A., Cabral D.M.B., Simi M., Aponte C., Rivas J.C., Gill S., Garcia A., Alvarenga G., Cespedes L., Perez H., Moreira M.L., Canete F., Gonzalez R., Monges N., Coman M., Pederzani M., Franco N., Aganon F., Martinez R., Noblezada-Uy D., Ellazar C.G., Cerezo F.D., Palo J.E., Aperocho C.A.J., Isanan M., Tubacka M., Jasiewicz P., Czuczwar M., Borys M., Gutysz-Wojnicka A., Glinka L., Gawda R., Bilawicz J., Cabrita P., Vieira J., Figueiredo M.F., Pinheiro C.M., Antunes N., Pedro L., Ferreira F., Parente I., Varela M., Fernandes F., Martins C., Viveiros A., Cavaco R., Rita C.S., Dias S., Feranandes A.M., Silva P., Nunes C., Cabral J., Pires F., Ferreira H., Santos J., Pinto V.M.V., Bispo B.M., Ferreira A., Molinos E., Lafuente E., Gregorio R., Costa H., Lima A., Ferreira S., Seromenho V., Luis E., Valerio I., Cesar H., Tavares A., Alsheikhly A.S., Mahmood S., Guran C.T., Moise A., Filipescu D.C., Luchian M., Popescu M., Scutariu M.A., Petrisor C., Hagau N., Grigoras I., Patrichi T., Gusarev V., Pivkina A., Kulakov V., Ignatenko O., Kovaleva J., Zhivotneva T., Zhedaeva M., Matiushkov N., Ershova O., Egorova N., Khoronenko V., Baskakov D., Sergeev D., Piradov M., Grishina L., Magomedov M., Zuev E., Gorokhovatsky U., Leonova A., Fadeeva L., Belskiy V., Galishevskiy D., Zubareva N., Tribulev M., Zueva O., Kiselev A., Kamenshchikov N., Tokareva E., Petrushin M., Starchenko I., Nshimyumuremyi I., Muhizi J., Buregeya E., Nzarora J., Assiri A., Ebaid M.S., Almekhlafi G., Mandourah Y., Velickovic J., Velickovic D., Jovanovic B., Hadzibegovic A., Stefanovic B., Misic V., Bumbasirevic V., Rajkovic M., Stojanovic M., Gavrilovic S., Stanojevic M., Yaghi A., Turcan A., Firment P., Rabarova D., Lancaricova D., Vlaovic J., Groznik M., Lukic M., Perme J., Sostaric M., Umek N., Mirkovic T., Dolenc S., Fister M., Zorko N., Markota A., Yeni N.P., Jali P., Schmollgruber S., Syed M.R., Parag N., Wise R., Galiana M., Navarro J.A., De Pablo A.M., Albert P., Martinez P., Mendiara Y., Garcia B., Llinas A.A., Riveiro M., Gallart E., Riera A., Sanz M., Salo S., Lajara M.A.G., Nieto M.V., Garcia R., Pena J.M.G., Gorgolas M.C., Isasi M.A., Sierra R., Gordo F., Conejo I., Salva-Costa V., Garzon-Tovar C., Lospitao S., Gutierrez P., Girona M., Adamuz J., Olivares P.G., de Ceballos J.P.G., Tirado C., De Wit I., Polo A.B.C., del Mar Diaz Salcedo M., Ripolles-Melchor J., Martinez-Hurtado E., Alvarez J.D., Arcas M.L.B., Gonzalez J.I.T., de la Ventana A.B.S., Calleja P.L.-A., Alvarez R.G., Zamora P.S., Guerrero A.O., Cosano R., Perez-Vacas J., Campos-Perez M., Barreiro E.M., Sanchez L.C., Diaz M.G., Jimenez R., Del Rio Cabajo L., Muriel D.S., Alonso H.F., Fernandez A.W., Pinan I.S., Albaiceta G.M., Fernandez M.C.I., Abos F.J.S., Monedero P., Chueca R.M., Aguirre L.G., Manosa S.C., Luque C.P., Calpe N., Losilla M.R., Fores M.T., Farre O., Fernandez O., del Rosario Villar Redondo M., Arteta Arteta D.S., Sanchez M.A.H., Espinosa C.P., Reyes L.M., Domenech L.C., Guillen C.V., Alvarez J.T., del Cotillo M., Barrueco-Francioni J.E., Conde B.B., Blanco M.P.S., Blasco M.L., Clement A.I., Hurtado C., Sanz L.C., Perez-Torres D., Prol-Silva E., Pereira J., Gonzalez I.A., Cano A.E., Nunez C.R., Fernadez I.L., Fernandez A.A.M., Del Bosque Diez R., Hilario B., Zalba-Etayo B., Pascual-Bielsa A., Banwarie P., Nahar D., van Axel A., Boedjawan N.N., Jansson E.B., Malvemyr A.-S., Johansson L., Sandberg U., Tingsvik C., Mattsson G., Lof G., Spangfors M., Ringdal M., Geijer S., Orvelius L., Hylen M., Lagerhall C., Akerman E., Hellkvist V.H., Mickelsson U., Wahlbom E., Larsson I.-M., Wallin E., Boroli F., Ory S., Jong M.L., Dullenkopf A., Lang M., Fleury Y., Maus M., Ben-Hamouda N., Fishman A., Hsu M.Y., Chang S.C., Trongtratul K., Sawawiboon C., Morakul S., Khwannimit B., Singh K., Ventour D., Figaro-Barclay D., Sankar-Maharaj S., Mebazaa M.S., Kamoun S., Elatrous S., Besbes L., Abroug F., Naija W., Elhechmi Y.Z., Sellami W., Hajjej Z., Merhabene T., Talik I., Kuscu O.O., Dilek O., Zerman A., Dal H.C., Turan S., Aydemir S., Yilmaz H., Calili D.K., Izdes S., Cengiz M., Gumus A., Tasdemir B., Kagnici A., Ay M., Ay S.A., Caliskan G., Akbas T., Balbay A.O., Efe S., Inal V., Elay G., Karabacak P., Ozserezli B., Senturk E., Demirkiran O., Bozbay S., Erdogan E., Akker M., Peker N., Ozgultekin A., Serin S.O., Turan C., Karaoren G., Goksu S., Karakurt S., Arikan H., Gul F., Cinel I., Kara I., Undar H.N., Bayraktar Y.S., Celik J.B., Tokur M.E., Aydin D.T., Yildiz I., Ozcan B., Erdivanli B., Eroglu A., Akdag D., Unlu N., Dungca A., Ali A., Thankamma B., Reyes P.E., John S., Rajendran A., Ahmad F.K.E., Smiley K.A., Hojden S., Miller M.T., Das Sasidharan Nair V., Antonio M.G.S., Qawasmeh K.A., Shawish S.A., Twiggs H., Rosado I., Babych V., Morren F., Young C., Vaughan-Jones N., Harris S., Burns K., Georgiev C., Shayamano R., Kerslake I., Creber P., Vochin A., O'Brien C., Caddell P., Hagan S., Hughes M., Torlinski T., Sherwin J., Kannan S., Markham A., Lebon R., Cupitt J., Cranshaw J., White N., Marriott V., Milner W., Groba C.B., Azoia J., Polgarova P., George S., Kapoor R., Lynch C., Fox N., Cranmer K., Llewellym T., Matthews K., Maltby L., Ibao J., Boulton K., Jarman R., Baxter K., Raj A.S., Moghal A., White J., Barrowcliffe S., Pulletz M., Ganeshalingam V., Baruah R., Baker H., Woods J., Ei P.P., Ogbeide V., Hayden P., Hughes J., Balasubramanian M., Salberg A., Saha R., Holmquist D., Derbyshire C., Smith N., Stones E., Ademokun J., Legorburo M.S., North S., Brett C., Jaundoo H., Craig J., Whiteley S., Howcroft C., Wilby L., Delve P., Shaw D., Williams K., Welters I.D., McMullen J., Brett S., Flores L., Trueman-Dawkins T., Templeton M., Adams J., Prowle J., Byers H., McDonnell A., Rose B.O., Reece-Anthony R., Mendes L., Vizcaychipi M., Bull R., Lacaden G., Santiago E., Delgado C.C., Farnell-Ward S., Thorpe E., Somerville J., Williams A., Cummings D., Derrick H., Brumwell S., Randell C., McCann N., Aves E., Berry G., Szakmany T., Gunter U., Pulak P., Sarkar N., Wright K., Gomes V., Jones J., Palfrey R., Camsooksai J., Lewis A., Eneas A., Tridente A., Barr L., Thomas B., Parkin E., Horner D., Frey C., Bench S., Baumber R., Broadhurst P., Jackson M., Williams L., Clark M., Paddle J., Bean S., Buckley S., Palfreeman C., Liu S., Allison N., Attwood B., Parsons P., Houghton V., Turner S.J., Higgins D., Bielskute E., Horrigan N., Jacob R., Habgood K., Zaki A., Collins A., Lord J., Ramiro C., Kubisz-Pudelko A., Kotze M., Williams H., Iovenko I., Tsarev A., Briva A., Mendez G., Napolitano L., Teig M., Rodriguez G.E., Ben-Jacob T., Potestio C., Eng T., Mahanes D., Khanna A., Duggal A., Nananmori M., Lois M., Karamchandani K., Bealer C., Barefield C., Terry D., Fivecoat P., Idowu O., Cata J., Clesi T., Peterson J., Hatton K., Dhaliwal J., Mueller D., Tao J., Eltorai A.S., Pastores S.M., Remor N., Salazar J., Barkas D., Joffe A., Barnes C., Sona C., Schallom M., Short J., Lorenzo J., Von Der Osten I., Borkowska M., Demarre L., Pleitinckx V., Xing C., Debue A.-S., Goller S., Larina E., Labeau, S. O., Blackwood, B., Brett, S. J., Deschepper, M., Francois, G., Honore, P. M., Khanna, A. K., Williams, G., Blot, S. I., Ribas, A. M., Telleria, V. M., Nogueira, P. C., Nafees, K. M. K., Reyes, A. G., Jensen, H. I., Adipa, F. E., Agoston, Z., Hashemian, S. M., Lee, S. -M., Abillama, F. F., Nor, B. M., Mazlan, M. Z., Sanchez-Hurtado, L., De lange, D., Ilesanmi, R. E., Ffarcsi, M. H., Hernandez, A. M., Schefold, J. C., Besbes, L. O., Minope, J. T. S., Rostello, O. F., Bartoli, J. R., Nocheretti, M. G., Escalante, R. G., Loudet, C. I., Gonzalez, A. L., Alvarez, G. A., Campos, P. A., Fonseca, I. P., Alvarez, G. M., Bascary, C. A., del Valle Gimenez, G., Bertoletti, F. P., Bonsignore, P. J. M., Fernandez, M. A., Leslie, G. D., Mclucas, A., Jacquet, L. -M., de Almeida, A. O., Jorge, S. A., Schmidt, R. C., Garcia, P. C., Ronchini, A. L. V., Manap, N. B. A., Laizner, A. M., Mcquirter, M., Kampayana, B. S., Sepulveda, M. I., Zamorano, M. J. F., Zhao, R. H., Hu, L. P., Jiao, Q. F., Wang, H. Y., Xia, C. J., Insu, L., Zhu, J. Y., Zhu, J. F., Huang, R. F., Wang, L. L., Song, J. H., Liu, X. M., Li, Z. S., Li, L. C., Zeng, J. M., Hu, X. C., Wang, R. X., Tak, P. S., Ho, S. W., Jiang, Q. X., Huang, L. P., Liu, X. L., Jiang, J. H., Gong, Y. Y., Lei, D. H., Bi, A. P., Zhao, H. M., Cao, Z. Q., Wu, S. F., Tian, X. F., Feng, Z. X., Liu, X. Z., Jiang, Z. X., Wang, G. X., Hu, R. L., Li, X. Q., Yu, Z. J., Yang, Y. X., Gama, L. M. S., Hernandez, J. S., Ochoa, M. -E., Reyes, A. J. G., Filipovic-Grcic, I., Vukovic, A., Pecenkovic, S., Suput, A., Radivojevic, R. C., Culjak, H., Adam, V. N., Pedersen, K. R., Kjaergard, I. E., Kodal, A. M., Hansen, T. C. B., Pedersen, A. S. B., Thomsen, T. D., Frandsen, T. M., Bliksted, I. A., Tamayo, L. M., Tutillo, D. R. M., Hurtado, C. V., Garcia, M. F., Kutimets, M., Lofqvist, C., Sakki, J. -K., Valta, M. A., Plantefeve, G., Deserts, M. D., Gunther, S. C., Timsit, J. -F., Farkas, J. -C., Bosl, K., Schuppel, S., Stubner, A., Osei, I. P., Kusi-Appiah, A. -C., Yakubu, Y. H., Patsiou, E. -C., Stalika, K. M. M., Enamorado, J. E., Jonasdottir, R. J., Lestari, M. I., Finn, D. O. C. R., Mcpherson, S., Ghioldi, D. M., Bruno, A. V., Maggiore, S. M., Volta, C. A., Taibi, M. R., Tranello, F. P., Giusti, G. D., Martin, M. A., Correia, M. C., Kim, J. H., Kim, K. C., Bae, J. -M., Park, S. Y., Park, T. S., Lee, H. B., Kim, S. C., Chee, H. K., Huh, J. W., Sim, Y. S., Ahn, J. -J., Kang, B. J., Lee, W. -Y., Lee, S. J., Feghaly, M. E., Belkhair, W. A., Tababa, O. W. E., Alkhumsi, S. I. R., Alshrif, A. I., Aboufray, A. A., Triki, A. R., Zahra, H. B., Al-Alawi, M. M. S., Ghula, M. A. A., Bahrin, L. K. K., Deva, S. R., Rahim, A. H. A., Hassan, W. N. W., Ismail, W. N. W., Ali, M. N., Khoo, T. M., Samat, N. M., Tong, J. M. G., Adib, N. A. N., Nor, M. B. M., Sulaiman, S. R., Foong, K. W., Hua, N. P., Zermeno, J. M., Nava, C. L. L., Nandyelly, S. J. R., Sanchez-Hurtado, L. A., Nava, L. P. A., Herrera, J. G., de Anda, G. F. V., Namendys-Silva, S. A., Romero-Gonzalez, J. P., Sosa, M. A., de Molina Serrano, J. I. R., Iburrigarro, S. R., Padilla, N. R. C., Pineda, A. A. V., Villafuerte, M. V. E., Herrera, M. O. G., Subedi, N. B., Pathak, S. D., Vermeijden, J. W., Gerritsen, R. T., Fijen, J. -W., Adejumo, P. O., Sankey, B. J., Olsen, B. F., Jensen, K. D., Johansen, B. F., Finnstrom, I. J., Skorstad, E. M., Lunde, G. A., Akselsen, G. R., Monstad, K. R., Hogvall, L., Malmin, S. K., Andersen, M. H., Hargott, R. F., de Jesus Ortiz, A., Cabral, D. M. B., Rivas, J. C., Moreira, M. L., Ellazar, C. G., Cerezo, F. D., Palo, J. E., Aperocho, C. A. J., Figueiredo, M. F., Pinheiro, C. M., Rita, C. S., Feranandes, A. M., Pinto, V. M. V., Bispo, B. M., Lima, A., Alsheikhly, A. S., Guran, C. T., Filipescu, D. C., Scutariu, M. A., Ebaid, M. S., Velickovic, D., Rajkovic, M., Stanojevic, M., Turcan, A., Lancaricova, D., Yeni, N. P., Syed, M. R., Navarro, J. A., De Pablo, A. M., Llinas, A. A., Lajara, M. A. G., Nieto, M. V., Pena, J. M. G., Gorgolas, M. C., Isasi, M. A., Salva-Costa, V., Garzon-Tovar, C., Olivares, P. G., de Ceballos, J. P. G., Polo, A. B. C., del Mar Diaz Salcedo, M., Alvarez, J. D., Arcas, M. L. B., Gonzalez, J. I. T., de la Ventana, A. B. S., Calleja, P. L. -A., Alvarez, R. G., Zamora, P. S., Guerrero, A. O., Barreiro, E. M., Sanchez, L. C., Diaz, M. G., Muriel, D. S., Alonso, H. F., Fernandez, A. W., Pinan, I. S., Albaiceta, G. M., Fernandez, M. C. I., Abos, F. J. S., Chueca, R. M., Aguirre, L. G., Manosa, S. C., Luque, C. P., Losilla, M. R., Fores, M. T., del Rosario Villar Redondo, M., Arteta Arteta, D. S., Sanchez, M. A. H., Espinosa, C. P., Reyes, L. M., Domenech, L. C., Guillen, C. V., Alvarez, J. T., del Cotillo, M., Barrueco-Francioni, J. E., Conde, B. B., Blanco, M. P. S., Blasco, M. L., Clement, A. I., Sanz, L. C., Gonzalez, I. A., Cano, A. E., Nunez, C. R., Fernadez, I. L., Fernandez, A. A. M., Boedjawan, N. N., Jansson, E. B., Malvemyr, A. -S., Lof, G., Spangfors, M., Lagerhall, C., Akerman, E., Hellkvist, V. H., Larsson, I. -M., Jong, M. L., Hsu, M. Y., Chang, S. C., Mebazaa, M. S., Elhechmi, Y. Z., Kuscu, O. O., Dal, H. C., Calili, D. K., Izdes, S., Gumus, A., Tasdemir, B., Kagnici, A., Ay, S. A., Balbay, A. O., Ozserezli, B., Senturk, E., Serin, S. O., Gul, F., Cinel, I., Undar, H. N., Bayraktar, Y. S., Celik, J. B., Tokur, M. E., Aydin, D. T., Yildiz, I., Ozcan, B., Akdag, D., Unlu, N., Reyes, P. E., Ahmad, F. K. E., Smiley, K. A., Miller, M. T., Antonio, M. G. S., Qawasmeh, K. A., Shawish, S. A., Groba, C. B., Raj, A. S., Ei, P. P., Legorburo, M. S., Welters, I. D., Mcmullen, J., Mcdonnell, A., Rose, B. O., Delgado, C. C., Mccann, N., Turner, S. J., Rodriguez, G. E., Eltorai, A. S., Pastores, S. M., Demarre, L., and Debue, A. -S.

Subjects
Male, Original, medicine.medical_treatment, artificial, Critical Care and Intensive Care Medicine, Medical and Health Sciences, Pressure ulcer, law.invention, Decubitus epidemiology, ICU, Morbidity, Mortality, Outcome, Pressure injury, Risk factors, Adult, Aged, Hospital Mortality, Humans, Patient Discharge, Prevalence, Risk Factors, Intensive Care Units, Respiration, Artificial, 0302 clinical medicine, decubitus epidemiology, pressure injury, pressure ulcer, outcome, risk factors, morbidity, mortality, law, Medicine and Health Sciences, adults, Medicine, Simplified Acute Physiology Score, icu, ziekenhuissterfte, Immunodeficiency, intensive care, European Society of Intensive Care Medicine (ESICM) Trials Group Collaborators, mannen, volwassenen, COST, Intensive care unit, STATE, ULCERS, Underweight, medicine.symptom, Life Sciences & Biomedicine, Human, medicine.medical_specialty, risicofactoren, Decubitus epidemiology, ICU, Pressure injury, Pressure ulcer, Outcome, Risk factors, Morbidity, Mortality, pressure injuries, Intensive Care Unit, prevalentie, NO, 1117 Public Health and Health Services, DecubICUs Study Team, 03 medical and health sciences, Critical Care Medicine, Anesthesiology, General & Internal Medicine, Health Sciences, ouderen, Mechanical ventilation, Science & Technology, business.industry, decubitus, Risk Factor, 030208 emergency & critical care medicine, 1103 Clinical Sciences, Odds ratio, medicine.disease, Emergency & Critical Care Medicine, Confidence interval, 030228 respiratory system, Emergency medicine, kunstmatige ademhaling, RISK-FACTORS, business, respiration
Abstract

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347, Funder: Flemish Society for Critical Care Nurses, Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score < 19, ICU stay > 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat.

Published
2021
Full Text
View/download PDF

37. Stroke prevention in patients from Latin American countries with non‐valvular atrial fibrillation: Insights from the GARFIELD‐AF registry

Author

Jerjes-Sanchez C., Corbalan R., Barretto A. C. P., Luciardi H. L., Allu J., Illingworth L., Pieper K. S., Kayani G., Fitzmaurice D. A., Goto S., Hacke W., Mantovani L. G., Turpie A. G. G., Gersh B. J., Gibbs H., Brodmann M., Cools F., Connolly S. J., Spyropoulos A., Eikelboom J., Hu D., Jansky P., Nielsen J. D., Ragy H., Raatikainen P., Le Heuzey J. -Y., Darius H., Keltai M., Kakkar S., Sawhney J. P. S., Agnelli G., Ambrosio G., Koretsune Y., Diaz C. J. S., ten Cate H., Atar D., Stepinska J., Panchenko E., Lim T. W., Jacobson B., Oh S., Vinolas X., Rosenqvist M., Steffel J., Angchaisuksiri P., Parkhomenko A., Al Mahmeed W., Chen K. N., Zhao Y. S., Zhang H. Q., Chen J. Z., Cao S. P., Wang D. W., Yang Y. J., Li W. H., Yin Y. H., Tao G. Z., Yang P., Chen Y. M., He S. H., Wang Y., Fu G. S., Li X., Wu T. G., Cheng X. S., Yan X. W., Zhao R. P., Chen M. S., Xiong L. G., Chen P., Jiao Y., Guo Y., Xue L., Wang F. Z., Li H., Yang Z. M., Bai C. L., Chen J., Chen J. Y., Chen X., Feng S., Fu Q. H., Gao X. J., Guo W. N., He R. H., He X. A., Hu X. S., Huang X. F., Li B., Li J., Li L., Li Y. H., Liu T. T., Liu W. L., Liu Y. Y., Lu Z. C., Luo X. L., Ma T. Y., Peng J. Q., Sheng X., Shi X. J., Sun Y. H., Tian G., Wang K., Wang L., Wu R. N., Xie Q., Xu R. Y., Yang J. S., Yang L. L., Yang Q., Ye Y., Yu H. Y., Yu J. H., Yu T., Zhai H., Zhan Q., Zhang G. S., Zhang Q., Zhang R., Zhang Y., Zheng W. Y., Zhou B., Zhou Z. H., Zhu X. Y., Jadhav P., Durgaprasad R., Ravi Shankar A. G., Rajput R. K., Bhargava K., Sarma R., Srinivas A., Roy D., Nagamalesh U. M., Chopda M., Kishore R., Kulkarni G., Chandwani P., Pothiwala R. A., Padinhare Purayil M., Shah S., Chawla K., Kothiwale V. A., Raghuraman B., Vijayaraghavan G., Vijan V. M., Bantwal G., Bisne V., Khan A., Gupta J. B., Kumar S., Jain D., Abraham S., Adak D., Barai A., Begum H., Bhattacharjee P., Dargude M., Davies D., Deshpande B., Dhakrao P., Dhyani V., Duhan S., Earath M., Ganatra A., Giradkar S., Jain V., Karthikeyan R., Kasala L., Kaur S., Krishnappa S., Lawande A., Lokesh B., Madarkar N., Meena R., More P., Naik D., Prashanth K., Rao M., Rao N. M., Sadhu N., Shah D., Sharma M., Shiva P., Singhal S., Suresh S., Vanajakshamma V., Panse S. G., Kanamori S., Yamamoto K., Kumagai K., Katsuda Y., Sadamatsu K., Toyota F., Mizuno Y., Misumi I., Noguchi H., Ando S., Suetsugu T., Minamoto M., Oda H., Shiraishi K., Adachi S., Chiba K., Norita H., Tsuruta M., Koyanagi T., Ando H., Higashi T., Okada K., Azakami S., Komaki S., Kumeda K., Murayama T., Matsumura J., Oba Y., Sonoda R., Goto K., Minoda K., Haraguchi Y., Suefuji H., Miyagi H., Kato H., Nakamura T., Nandate H., Zaitsu R., Fujiura Y., Yoshimura A., Numata H., Ogawa J., Tatematsu H., Kamogawa Y., Murakami K., Wakasa Y., Yamasawa M., Maekawa H., Abe S., Kihara H., Tsunoda S., Saito K., Fudo T., Obunai K., Tachibana H., Oba I., Kuwahata T., Higa S., Gushiken M., Eto T., Yoshida H., Ikeda D., Ishizawa M., Nakatsuka M., Murata K., Ogurusu C., Shimoyama M., Akutsu M., Takamura I., Hoshino F., Yokota N., Iwao T., Tsuchida K., Takeuchi M., Hatori Y., Kitami Y., Nakamura Y., Oyama R., Ageta M., Go Y., Mishima K., Unoki T., Morii S., Shiga Y., Sumi H., Nagatomo T., Sanno K., Fujisawa K., Atsuchi Y., Nagoshi T., Seto T., Tabuchi T., Kameko M., Nii K., Oshiro K., Takezawa H., Nagano S., Miyamoto N., Iwaki M., Fujii M., Okawa M., Abe M., Saito T., Mito T., Nagao K., Minami J., Mita T., Sakuma I., Taguchi T., Marusaki S., Doi H., Tanaka M., Fujito T., Matsuta M., Kusumoto T., Kakinoki S., Ashida K., Yoshizawa N., Agata J., Arasaki O., Manita M., Ikemura M., Fukuoka S., Murakami H., Matsukawa S., Hata Y., Taniguchi T., Ko T., Kubo H., Imamaki M., Akiyama M., Inagaki M., Odakura H., Ueda T., Katsube Y., Nakata A., Watanabe H., Techigawara M., Igarashi M., Taga K., Kimura T., Tomimoto S., Shibuya M., Nakano M., Ito K., Seo T., Hiramitsu S., Hosokawa H., Hoshiai M., Hibino M., Miyagawa K., Horie H., Sugishita N., Soma A., Neya K., Yoshida T., Mizuguchi M., Ishiguro M., Minagawa T., Wada M., Mukawa H., Okuda F., Nagasaka S., Abe Y., Adachi T., Akahane K., Amano T., Aoki K., Aoyama T., Arai H., Arima S., Arino T., Asano H., Asano T., Azuma J., Baba T., Betsuyaku T., Chibana H., Date H., Doiuchi J., Emura Y., Endo M., Fujii Y., Fujiki R., Fujisawa A., Fujisawa Y., Fukuda T., Fukui T., Furukawa N., Furukawa T., Furumoto W., Goto T., Hamaoka M., Hanazono N., Hasegawa K., Hatsuno T., Hayashi Y., Higuchi K., Hirasawa K., Hirayama H., Hirose M., Hirota S., Honda M., Ido T., Iiji O., Ikeda H., Ikeda K., Ikeoka K., Imaizumi M., Inaba H., Inoue T., Iseki F., Ishihara A., Ishioka N., Ito N., Iwase T., Kakuda H., Kamata J., Kanai H., Kanda H., Kaneko M., Kano H., Kasai T., Kato T., Kato Y., Kawada Y., Kawai K., Kawakami K., Kawakami S., Kawamoto T., Kawano S., Kim J., Kira T., Kitazawa H., Kitazumi H., Kito T., Kobayashi T., Koeda T., Kojima J., Komatsu H., Komatsu I., Koshibu Y., Kotani T., Kozuka T., Kumai Y., Kumazaki T., Maeda I., Maeda K., Maruyama Y., Matsui S., Matsushita K., Matsuura Y., Mineoi K., Mitsuhashi H., Miura N., Miyaguchi S., Miyajima S., Miyamoto H., Miyashita A., Miyata S., Mizuguchi I., Mizuno A., Mori T., Moriai O., Morishita K., Murai O., Nagai S., Nagata E., Nagata H., Nakagomi A., Nakahara S., Nakamura M., Nakamura R., Nakanishi N., Nakayama T., Nakazato R., Nanke T., Nariyama J., Niijima Y., Niinuma H., Nishida Y., Nishihata Y., Nishino K., Nishioka H., Nishizawa K., Niwa I., Nomura K., Nomura S., Nozoe M., Ogawa T., Ohara N., Okada M., Okamoto K., Okita H., Okuyama M., Ono H., Ono T., Pearce Y. O., Oriso S., Ota A., Otaki E., Saito Y., Sakai H., Sakamoto N., Sakamoto Y., Samejima Y., Sasagawa Y., Sasaguri H., Sasaki A., Sasaki T., Sato K., Sawano M., Seki S., Sekine Y., Seta Y., Sezaki K., Shibata N., Shiina Y., Shimono H., Shimoyama Y., Shindo T., Shinohara H., Shinohe R., Shinozuka T., Shirai T., Shiraiwa T., Shozawa Y., Suga T., Sugimoto C., Suzuki K., Suzuki S., Suzuki Y., Tada M., Taguchi A., Takagi T., Takagi Y., Takahashi K., Takahashi S., Takai H., Takanaka C., Take S., Takeda H., Takei K., Takenaka K., Tana T., Tanabe G., Taya K., Teragawa H., Tohyo S., Toru S., Tsuchiya Y., Tsuji T., Tsuzaki K., Uchiyama H., Ueda O., Ueyama Y., Wakaki N., Wakiyama T., Washizuka T., Watanabe M., Yamada T., Yamagishi T., Yamaguchi H., Yamamoto T., Yamaura M., Yamazoe M., Yasui K., Yokoyama Y., Yoshida K., Ching C. K., Foo C. G., Chow J. H., Chen D. D., Jaufeerally F. R., Lee Y. M., Lim G., Lim W. T., Thng S., Yap S. Y., Yeo C., Pak H. N., Kim J. -B., Kim J. H., Jang S. -W., Kim D. H., Ryu D. R., Park S. W., Kim D. -K., Choi D. J., Oh Y. S., Cho M. -C., Kim S. -H., Jeon H. -K., Shin D. -G., Park J. S., Park H. K., Han S. -J., Sung J. H., Cho J. -G., Nam G. -B., On Y. K., Lim H. E., Kwak J. J., Cha T. -J., Hong T. J., Park S. H., Yoon J. H., Kim N. -H., Kim K. -S., Jung B. C., Hwang G. -S., Kim C. -J., Kim D. B., Ahn J. J., An H. J., Bae H., Baek A. L., Chi W. J., Choi E. A., Choi E. H., Choi H. K., Choi H. S., Han S., Heo E. S., Her K. O., Hwang S. W., Jang E. M., Jang H. -S., Jang S., Jeon H. -G., Jeon S. R., Jeon Y. R., Jeong H. K., Jung I. -A., Kim H. J., Kim J. S., Kim J. A., Kim K. T., Kim M. S., Kim S. H., Kim Y. -I., Lee C. S., Lee E. H., Lee G. H., Lee H. Y., Lee H. -Y., Lee K. H., Lee K. R., Lee M. S., Lee M. -Y., Lee R. W., Lee S. E., Lee S. H., Lee S., Lee W. Y., Noh I. K., Park A. R., Park B. R., Park H. N., Park J. H., Park M., Park Y., Seo S. -Y., Shim J., Sim J. H., Sohn Y. M., Son W. S., Son Y. S., Song H. J., Wi H. K., Woo J. J., Ye S., Yim K. H., Yoo K. M., Yoon E. J., Yun S. Y., Chawanadelert S., Mongkolwongroj P., Kanokphatcharakun K., Cheewatanakornkul S., Laksomya T., Pattanaprichakul S., Chantrarat T., Rungaramsin S., Silaruks S., Wongcharoen W., Siriwattana K., Likittanasombat K., Katekangplu P., Boonyapisit W., Cholsaringkarl D., Chatlaong B., Chattranukulchai P., Santanakorn Y., Hutayanon P., Khunrong P., Bunyapipat T., Jai-Aue S., Kaewsuwanna P., Bamungpong P., Gunaparn S., Hongsuppinyo S., Inphontan R., Khattaroek R., Khunkong K., Kitmapawanont U., Kongsin C., Naratreekoon B., Ninwaranon S., Phangyota J., Phrommintikul A., Phunpinyosak P., Pongmorakot K., Poomiphol S., Pornnimitthum N., Pumprueg S., Ratchasikaew S., Sanit K., Sawanyawisuth K., Silaruks B., Sirichai R., Sriwichian A., Suebjaksing W., Sukklad P., Suttana T., Tangsirira A., Thangpet O., Tiyanon W., Vorasettakarnkij Y., Wisaratapong T., Wongtheptien W., Wutthimanop A., Yawila S., Altun A., Ozdogru I., Ozdemir K., Yilmaz O., Aydinlar A., Yilmaz M. B., Yeter E., Ongen Z., Cayli M., Pekdemir H., Ozdemir M., Sucu M., Sayin T., Demir M., Yorgun H., Ersanli M., Okuyan E., Aras D., Abdelrahman H., Aktas O., Alpay D., Aras F., Bireciklioglu M. F., Budeyri S., Buyukpapuc M., Caliskan S., Esen M., Felekoglu M. A., Genc D., Ikitimur B., Karaayvaz E. B., Karatas S. K., Okutucu S., Ozcelik E., Quisi A., Sag H., Sahiner L., Sayin B. Y., Seker T., Alkan D. U., Yildirim E., Yildirim R., Yilmaz F., Yuksekdag V., Vensentini N., Ingaramo A. C., Sambadaro G. A., Caputi V. F., Berman S. G., Dragotto P., Kleiban A. J., Centurion N., Giacomi G., Guerrero R. A. A., Conde D., Zapata G., Di Paola L. A., Ramos J. L., Dran R. D., Egido J., Fernandez A. A., Fosco M. J., Sassone S., Sinisi V. A., Cartasegna L. R., Berli M. A., Vilamajo O. A. G., Ferroni F., Alaguibe E. D., D'Amelio A. A., Arabetti C., Arias L., Belardi J. A., Bergesio L., Berli F., Berli M., Borchowiec S., Buzzetti C., Cabrini R., Campisi V., Cappi A. L., Carrizo R., Berra F. C., Costabel J. P., Costamagna O. J. A., Damonte A. A., De Urquiza I. N., Diez F., Eden M. F., Fanuele M., Voena F. F., Torres M. F., Funosas C., Giacomi M. P., Gimenez C. H., Gurfinkel E. P., Had M. D. L. M., Hansen V., Hrabar A. D., Ingratta M., Lopez A., Maehara G., Maffei L., Martinelli A., Martinelli C., Matkovich J., Mautner B., Meirino A., Munguia R., Navarro A., Novas V., Prados G. P., Pontoriero J., Potito R. N., Ricotti C., Rodriguez M. A., Rolandi F., Palladino M. E. S., Salinger M., Sanziani L. S., Schygiel P. O., Sossich A., Tinto J. F., Tonelli L., Tufare A. L., Vallejo M., Yunis M. E., Zillo M., Zurbrigk F. J., Filho D. C. S., Jaber J., Armaganijan D., Neto J. F., Steffens A., de Souza W. K. S. B., de Souza Neto J. D., Ribeiro J. M., Teixeira M. S., Rossi P. R. F., Pires L., Moreira D., Jorge J. C. M., Filho A. M. L., Bodanese L. C., Montera M. W., Del Carlo C. H., Rodrigues T. D. R., da Costa F. A. A., Lopes A., Lopes R., Araujo G. R., Manenti E. R. F., Saraiva J. F. K., Braga J. C. F., Negri A., Souto L., Moncada C., Precoma D. B., Roquette F., Reis G., Filho R. A. R., Figueiredo E. L., Botelho R. V., Tavares C. M. D. F., Frack C. R. C., Saad J. A., Finimundi H. C., Pisani C., Chemello D., Martins M. P., Franca C. C. B., Alban F., Rosito G. B. A., Moraes Junior J. B. M. X., Tumelero R. T., Maia L. N., de Almeida R. S., do Carmo Borges N. C., Ferreira L. G. G., Agliardi P., Gomes J. A. O., Araujo V., Nakazone M. A., Barbosa T., Barroso S., Falchetto E. B., Lopes H. B., Lemos M. A. B. T., Biazus G., Queiroz L. B., Camazzola F. E., Caporale M., Cardoso Boscato S., Chieza F., Chokr M. O., Mingireanov R. C., Goes N. C., Correa C., Costa M., Ortiz C. C., da Silva L. S., Paulitsch F. D. S., da Silveira J. A., Daros E., de Araujo G. R., Del Monaco M. I., Dias C., Dias M. A., Wainstein A. P. D., Pizzato P. E., Esteves D. C., Fabri P., Fonseca T. F. L., Fernandes E., Fonseca C., Costantini C. R. F., Ferraz R. F., Freire F., Gottardo P., Guanaes D., Guizzardi S., Magedanz E. H., Igansi F., Jannuzzi F., Junior G., Komar D., Lino E. G., Lopes D., Junior O. L. D. S., Lustosa E., Macagnan A. P., Marinho M. C., Mazzoni M., Melo G., Mortari L., Mouco O. M. C. C., Vital C. N., Ormundo C., Emmer S. O., Palmegiani E., Pavani R., Pereira L., Pereira V. L., Perreira R., Poletti S., Fortunato S. C. Q., Queirantes C., Pereira N. R., Rech R. L., Ribeiro S., Rodrigues A., Roesch H., Reichert T. R., Santos D., Santos I., Santos M., Seroqui M. V., Silva S., Soares L., Spolaor L., Stoll C., Duda N. T., Trama L., Unterkircher B., Valois M. V., Vargas T., Viana T., Vicente C., Armaganijan L. V., Homem R. V., Torres L. G. V., Vila L., Filho F. V. G., Eggers G., Gutierrez C. B., Arriagada G., Cardenas S. P., Fernandez B. A. J. S., Conejeros C., Houzvic C., Cuevas P. M., Montecinos H., Forero A., Lanas F., Gomez M. L., Vilches G. C., Rey C., Astudillo C., Aguilar J., Campisto Y., Lara C., Molina E., Oyarzon J. M., Olguin V., Vergara M., Villan C., Diaz J. I., Cantu R. L., Zavala M. G. R., Jardines R. C., Zavaleta N. E., Umana S. V., Rosas E. L., Esperon G. L., Pozas G., Munoz E. C., Hernandez N. M., Rendon A. L., Hernandez N. G., Ibarra M. L. R., Carrillo L. V., Villezca D. L., Herrera C. H., Prieto J. J. L., Rodriguez R. G., Espinosa E. V., Martinez D. F., Barcena J. V., Yong R., Briones I. R., Pons J. L. L., Lopez H. A., Ruiz R. O., de la Vega C. D., Brito C. C., Valenzuela E. C., Reyes-Sanchez R., Ruiz A. B., Flores O. N., Gonzalez M. B., Nava R. A., Cerda J. D. M., Fierro O. F., Campos P. F., Alfaro T. A. A., Bellorin S. A., Avena R., Chavarria M., Espinosa I., Silva F. F., Nava R. H. G., Godoy K., Felix E. J. G., Garcia C. L. G., Salas L. G. G., Guajardo P., Gonzalez S. H., Izquierdo T., Ortiz M. C. M., Vasquez D. M., Mendoza N., Morales J., Nikitina N., Aybar S. O., Ortiz A., Macias P. P., Perez F., Sanchez J. A. P., Toledano S. P., Gonzalez M. R., Ramos C. R., Castro V. R., Cardona G. R., Cornejo M. R., Salinas A., Santana G., Perez P. S., Castaneda A. C. T., Cortes R. T., Lenz K., Drexel H., Foechterle J., Hagn C., Podczeck-Schweighofer A., Huber K., Winkler M., Schneeweiss B., Gegenhuber A., Lang W., Eichinger-Hasenauer S., Kaserer P., Sykora J., Rasch H., Pichler M., Schaflinger E., Strohmer B., Breier R., Ebner K. -M., Eischer L., Freihoff F., Lischka-Lindner A., Mark T., Mirtl A., Said A., Stocklocker C., Vogel B., Vonbank A., Wohrer C., Zanolin D., Paparella G., Vandergoten P., Parque J. -L., Capiau L., Vervoort G., Wollaert B., Desfontaines P., Mairesse G., Boussy T., Godart P., De Wolf A., Voet J., Heyse A., Hollanders G., Anne W., Vercammen J., Purnode P., Blankoff I., Faes D., Balthazar Y., Beutels M., Marechal P., Verstraete S., Xhaet O., Striekwold H., Thoeng J., Hermans K., Alzand B., Ascoop A. -K., Banaeian F., Barbuto A. -M., Billiaux A. C., Blockmans M., Bouvy C., Brike C., Capiau H., Casier T., Bolado A. C. Y., De Cleen D., De Coninck M., de Vos M., de Weerdt N., Delforge M., Delvigne M., Denie D., Derycker K., Deweerd E., Dormal F., Drieghe S., Everaert M., Eykerman T., Feys E., Ghekiere M., Gits F., Hellemans S., Helvasto L., Jacobs C., Lips S., Mestdagh I., Nimmegeers J., Piamonte V., Pollet P., Postolache A., Raepers M., Raymenants E., Richa J., Rombouts H., Salembier J., Scheurwegs C., Semeraro O., Simons N., Smessaert C., Smolders W., Stockman I., Tahon S., Thyssen V., Tincani G., Van Durme F., Van Lier D., Vandekerckhove H., Vandekerckhove Y., Vandenbroeck D., Vandorpe A., Vanhalst E., Vanhauwaert B., Vantomme C., Vergauwen L., Verloove H., Vydt T., Weyn T., Reichert P., Spacek R., Machova V., Zidkova E., Ludka O., Olsr J., Kotik L., Plocova K., Racz B., Ferkl R., Hubac J., Kotik I., Monhart Z., Burianova H., Jerabek O., Pisova J., Petrova I., Dedek V., Honkova M., Podrazil P., Spinar J., Vitovec J., Novak M., Lastuvka J., Durdil V., Antonova P., Bockova L., Bultas J., Chlumsky J., Dastychova L., Drasnar T., Honek J., Horejsi M., Hubacova V., Janska L., Kopeckova I., Kratochvilova R., Krcova E., Labrova R., Lindourkova A., Lipoldova J., Lubanda H., Ludkova A., Mahdalikova L., Majernikova M., Michalik D., Potuznik P., Prochazkova E., Sulc A., Sveceny J., Valtova M., Zidek M., Zika J., Nielsen H., Husted S., Hintze U., Rasmussen S., Bremmelgaard A., Markenvard J., Boerger J., Solgaard J., Simonsen P., Loekkegaard T., Bruun M., Mertz J., Dominguez H., Skagen K., Egstrup K., Ibsen H., Raymond I., Bang-Hansen T., Ellervik C., Eriksen E., Jensen L., Jensen M., Leth M., Nygaard A., Park J., Schou M., Therkelsen A., Tilma J., Vesterager K., Airaksinen J., Arola O., Koistinen J., Nappila H., Peltomaki K., Rasanen V., Vasankari T., Galinier M., Gottwalles Y., Paganelli F., Loiselet P., Muller J. -J., Koujan M. B., Marquand A., Destrac S., Piot O., Delarche N., Cebron J. -P., Boveda S., Guenoun M., Guedj-Meynier D., Galley D., Ohayon J., Assouline S., Zuber M., Amarenco P., Ellie E., Kadouch J., Fournier P. -Y., Huberman J. -P., Lemaire M., Rodier G., Milandre L., Vandamme X., Sibon I., Neau J. -P., Mahagne M. H., Mielot A., Bonnefoy M., Churet J. -B., Navarre V., Sellem F., Monniot G., Boyes J. -P., Doucet B., Martelet M., Obadia D., Crousillat B., Mouallem J., Bearez E., Nazeyrollas P., Brugnaux J. P., Fedorowsky A., Casassus F., Berneau J. -B., Chemin F., Falvo N., Perron J. -M., Poulard J. -E., Barreau A., Beltra C., Corrihons E., Decarsin N., Dubois B., Ducasse E., Giry X., Kemmel A., Ledure S., Lemaire N., Robin F., Rosolin N., Sanchez D., Suissa A., Koniger G., Purr J., Gerbaulet U., Kellner B. -T., Kopf A., Schafer T., Zauzig H., Riegel P., Hohensee H., Eissfeller E., Eder W., Rehling G., Glatzel D., Zutz S., Heinz G. -U., Menke H., Pustelnik A., Sandow P., Ludwig N., Wiswedel H., Wildenauer W., Axthelm C., Schwarz T., Babyesiza A., Stuchlik G., Zimny H. -H., Kropp M., Kahl F., Caspar A., Omankowsky S., Lassig T., Hartmann H. -J., Lehmann G., Bindig H. -W., Hergdt G., Reimer D., Hauk J., Dorsch W., Dshabrailov J., Michel H., Rapp K. -A., Vormann R., Mayer P., Horstmeier U., Eissing V., Hey H., Leuchtgens H., Lilienweiss V., Kolitsch K., Schubert C., Lauer H., Buchner T., Brauer G., Kamin S., Muller K., Abdel-Qader M., Baumbach S., Ebert H. -H., Schwencke C., Schellong S., Bernhardt P., Karolyi L., Sievers B., Haverkamp W., Salbach P., Rohnisch J. -U., Schoen S., Erdle W., Mueller T., Mueller H., Mitrovic V., Babjakova Z., Bergner K., Boehme S., Bonin K., Buckert D., Busch F., Dichristin U., Diez S., Fleck A., Flint K., Floegel H., Fritz C., Frommhold R., Gehre J., Geyer J., Grytzmann A., Hahn M., Helgert K., Hubert K., Kirchner-Volker K., Klein V., Kroll D., Krueger A., Lehmann R., Mann L., Maselli A., Menken G., Mikes K., Mortan H., Nasser N., Nicolaus D., Plauskat A., Pomper L., Quietzsch A., Ravenhorst C., Reichelt C., Reimer C., Schaefer B., Scharrer S., Schirmer K., Schmidt K., Schoene R., Schulze J., Schuppe M., Simon S., Sommer S., Spranger K., Talkenberger A., Tauber K., Tetlak A., Toennishoff T., Voelkel-Babyesiza R., Voigts B., Weiser U., Wesendorf S., Wildenauer S., Wolf T., Wurziger J., Zak J., Zauzig H. -D., Ziefle S., Zincke S., Vangel S., Szalai G., Merkely B., Kancz S., Boda Z., Nagy A., Laszlo Z., Matoltsy A., Gaszner B., Polgar P., Habon T., Noori E., Juhasz G., Kanakaridisz N., Szentpeteri I., Juhasz F., Vertes A., Papp A., May Z., Ferenczi J., Egyutt M., Kis E., Engelthaler G., Szantai G., Fulop E., Gombos P., Gulyas D., Jen P., Kiralyhazine Gyorke E., Kovacs M., Kovacsne Levang S., Marianna S., Radics Z., Sydo N., Szalo R., Szilagyi A., Sztanyik F., Vandrus B., Tiraferri E., Santoro R., Testa S., Di Minno G., Moia M., Caimi T. M., Martini G., Tessitori M., Cappelli R., Poli D., Quintavalla R., Melone F., Cosmi F., Pizzini A., Piseddu G., Fanelli R., Latella C., Santi R., Pancaldi L., De Cristofaro R., Palareti G., De Blasio A., Salerno Uriarte J., Minetti F., Pogliani E. M., Lonati L. M., Accogli M., Ciampani N., Malengo S., Feola M., Raisaro A., Fattore L., Grilli P., Germini F., Settimi M., Alunni M., Duranti G., Tedeschi L., Baglioni G., Avanzino G., Berardi M., Pannacci V., Giombolini A., Nicoli S., Scarponi T., Allasia B., Ricciarini P., Nasorri R., Argena A., Bossolasco P., Ronchini P., Filippi A., Tradati F., Bulla C., Donzelli L., Foppa L., Bottarelli M. L., Tomasello A., Mauric A., Femiano C., Reggio R., Lillo F., Mariani A., Forcignano F., Volpe M., D'Avino M., Bongiorni M. G., Severi S., Capucci A., Lodigiani C., Salomone E., Serviddio G., Tondo C., Golino P., Mazzone C., Iacopino S., Pengo V., Galvani M., Moretti L., Ambrosino P., Banfi E., Biagioli V., Bianchi A., Boggian G., Breschi M., Brusorio S., Calcagnoli F., Campagna G., Carpenedo M., Ciabatta C., Ciliberti G., Cimmino G., D'Arienzo C., Di Gennaro L., Fedele M., Ferrini P. M., Granzow K., Guazzaloca G., Guerra F., Lo Buglio A., Longo S., Macellari F., Mesolella E., Mollica Poeta E., Occhilupo P., Oriana V., Rangel G., Salomone L., Scaccianoce A., Scarone C., Segreti L., Sottilota G., Villani R., Zecca C., Ruiter J. H., Klomps H., Bongaerts M., Pieterse M. G. C., Guldener C., Herrman J. -P., Lochorn G., Lucassen A., Adriaansen H., The S. H. K., Nierop P. R., Hoogslag P. A. M., Hermans W., Groenemeijer B. E., Terpstra W., Buiks C., Boersma L. V. A., Boersma-Slootweg M., Bosman F., Bosschaert M., Bruin S., Danse I., De Graaf J., de Graauw J., Debordes M., Dols S., Geerlings F., Gorrebeeck K., Jerzewski A., Jetten W., Kelderman M., Kloosterman T., Koomen E. M., Krikken J., Melman P., Mulder R., Pronk A., Stallinga-de Vos A., te Kaat J., Tonino P., Uppelschoten B., van de Loo R., van der Kley T., van Leeuwen G., van Putten J. J., Westerman L., Berge E., Sirnes P. A., Gjertsen E., Hole T., Erga K., Hallaraker A., Skjelvan G., Ostrem A., Ghezai B., Svilaas A., Christersson P., Oien T., Hoegh Henrichsen S., Berg-Johansen J., Otterstad J. E., Antonsen H., Ausen K., Claussen H., Dominguez I., Jekthammer A., Lensebraaten A. B., Nilsen V., O'Donovan M., Ringdalen K., Strand S., Korzeniak R., Gieroba A., Biedrzycka M., Ogorek M., Wozakowska-Kaplon B., Loboz-Grudzien K., Kosior J., Supinski W., Kuzniar J., Zaluska R., Hiczkiewicz J., Swiatkowska-Byczynska L., Kucharski L., Gruchala M., Minc P., Olszewski M., Kania G., Krzciuk M., Lajkowski Z., Ostrowska-Pomian B., Lewczuk J., Zinka E., Karczmarczyk A., Chmielnicka-Pruszczynska M., Trusz-Gluza M., Opolski G., Bronisz M., Glanowska G., Ruszkowski P., Jaworska K., Sciborski R., Okopien B., Kukla P., Wozniak-Skowerska I., Galbas K., Cymerman K., Jurowiecki J., Miekus P., Myszka W., Mazur S., Lysek R., Baszak J., Rusicka-Piekarz T., Raczak G., Domanska E., Nessler J., Lesnik J., Ambicka M., Andrzejewski D., Araminowicz J., Barszcz A., Bartkowiak R., Bartnik J., Basiak M., Bekieszczuk E., Bernat L., Biedrzycki L., Biernacka A., Blaszczyk D., Broton E., Brzozowski W., Brzustowska M., Bzymek R., Chmielowski A., Chojnowski P., Cichomski R., Cieslak K., Cieszynska A., Curyllo B., Czamara M., Danilowicz-Szymanowicz L., Dolecka B., Drelich L., Dudzik-Richter B., Dybala T., Dziuba M., Faron W., Figura-Chmielewska M., Frankiewicz A., Gadzinski W., Gasior E., Gosciniecka B., Gutknecht P., Guziewicz M., Jackun-Podlesna A., Jaguszewska G., Jankielewicz J., Jaremczuk-Kaczmarczyk A., Jargiello-Baszak M., Jarzebowski A., Jaskulska-Niedziela E., Jaworska-Drozdowska M., Kabat J., Kaczmarzyk-Radka A., Kalin K., Kaliszczak R., Kiliszek M., Klata M., Kluczewski M., Kobielusz-Gembala I., Kochanska E., Kociolek D., Kolodzinska A., Komlo A., Konopka A., Korczowska E., Kowal E., Kowalczyk H. K., Kremis E., Kruczyk D., Krzesiak-Lodyga A., Krzyzanowski M., Kurdzielewicz W., Kustrzycka-Kratochwil D., Lesniewska-Krynska D., Leszczynski J., Lewicka E., Lichota E., Lip K., Loboz-Rudnicka M., Luka J., Lysek-Jozefowicz A., Machnikowska M., Majewska K., Mariankowski R., Markiewicz A., Mazur M., Metzgier-Gumiela A., Miedlar E., Mielcarek M., Neubauer-Geryk J., Niedek J., Niemirycz-Makurat A., Nowak A., Nowak S., Opielowska-Nowak B., Ozgowicz M., Pawelska-Buczen A., Pawlik-Rak E., Piotrowicz R., Ptaszynski P., Raczynska A., Rogowski W., Romanek J., Romaszkiewicz R., Rostoff P., Roszczyk N., Rozewska-Furmanek D., Rychta J., Rzyczkowska B., Sidor A., Skalska J., Smichura M., Splawski M., Staneta P., Staniszewska E., Starak-Marciniak J., Stopyra-Poczatek M., Sukiennik-Kujawa M., Szafranski J., Szalecki P., Szczepanska A., Szkrobka W., Szuchnik E., Szulowska A., Szumczyk-Muszytowska G., Szwoch M., Traczyk T., Troszczynska M., Trzcinski G., Tybura S., Walasik P., Wegrzynowska M., Wesolowska K., Wieczorek W., Wierzbicka A., Wilczewski P., Wilgat-Szecowka M., Wojewoda P., Wojnowski L., Wrobel M., Zakutynska-Kowalczyk K., Zyczynska-Szmon M., Eltishcheva V., Libis R., Tereshchenko S., Popov S., Kamalov G., Belenky D., Zateyshchikova A., Kropacheva E., Kolesnikova A., Nikolaev K., Egorova L., Khokhlov A., Yakupov E., Poltavskaya M., Zateyshchikov D., Drapkina O., Vishnevsky A., Barbarash O., Miller O., Aleksandrova E., Chizhov P., Sergeev M., Shutemova E., Mazur E., Zrazhevskiy K., Novikova T., Kostenko V., Moiseeva Y., Polkanova E., Sobolev K., Rossovskaya M., Zubeeva G., Shapovalova Y., Nagibovich O., Edin A., Agakhanyan A., Batalov R., Belenkova Y., Bitakova F., Chugunnaya S., Dumikyan A., Erofeeva S., Gorbunova E., Gorshkova T., Gubanov A., Gurmach M., Ivanova Y., Kolesova T., Konyushenko D., Korneeva O., Kropova O., Kuchuk P., Kungurtseva O., Kupriyanova T., Kurylo B., Kuvanova M., Lebedeva O., Lileeva E., Machilskaya O., Medvedeva T., Monako G., Motylev I., Nagibovich G., Novikova E., Orlov Y., Osmolovskaya Y., Ovsannikova A., Platonov D., Rachkova S., Sinitsina O., Speshilova S., Suslova O., Ushakov A., Volodicheva O., Zemlianskaia O., Zhirov I., Zhuravleva E., Zotova I., Garcia P. A., Fernandez M. F. L., Tercedor L., Iparraguirre S. T., Monserrat P. T., Contreras E. M., Rafecas J. I., Carrasco J. M., Pavia P. G., Pajuelo C. G., Serrano C. M., Alonso L. F. I., Ruiz A. G., Klein J. M., Juanatey J. R. G., Esquivias G. B., Collado I. M., Piquero H. P., Cuixart C. B., Morato M. R., Llibre J. B. I., Vicente C. C., Gutierrez M. V., Gonzalo F. E., Fernandez C. A. A., Plana N. D. V., Montserrat E. E., Alia J. J. M., Oliva M. A. M., Sanmartin J. I., Gonzalez M. J., Alvarez M. R., Melenchon J. H., Vera T. R., Soriano F. R., Riesco L. G., Macian M. D. M., Granado J. Q., Navarro M. J., Sales J. C., Perez J. V. V., Caamano M. V., Torres M. F. A., Gomez G. M., Romo A. I., Diaz M. A. P., Alonso C., Alvarez D., Alvarez M., Amaro M., Andere N., Villar J. A., Ochoa R. A., Austria A., Barbeira S., Feu E. B., Bartes A., Munoz V. B., Jimenez F. J. B., Tijuan A. B., Ramirez J. C., Ramos M. C., Martinez E. C., Moreno M. C., Corchado G. C., Gil M. C., Orive M. C., Fernandez D. C., del Misterio M. C., Alsina R. C., Cabrera A. C., de Faria J. C. P. P., Costas S., Marco M. I. C., Dachs M., Lopez C. M. D., Borras A. D., Madariaga A. E., Espallargas A., Fernandez M., Escobar E. F., Mas E. F., Ferrer A., Fosch J., Bermudez M. G., Millan V. G., Saenz M. G., Garcia C. G., Gomez C., Perez Y. G., Segovia A. G., Gonzalez P., Grigorian L., Molina A. G., del Val M. C. G., Maeso B. H., Rodriguez E. H., Garcia A. I., Fernandez M. J. J., Besa B. J., Salvadores P. J., Bouzamayor M. B. L., Lasuncion I., Gort L. E. L., Molina M. L., Lopez M., Rey A. M., Guerra J. M., Marcus S., Vila A. M., Mena M. M., Mazon P., Zurita F. M., Millan G., Molina M., Alia P. M., Montes D., Gonzalez M. M., Munoz R. B. M., Palma A. N., Figueroa H. N. O., Ortega V. M., Cortes C. O., Tomera D. O., Merchan N. P., Ibar I. P., Garcia E. P., Armayor M. P., Carasa M. P., Prieto I., Quintern V., Renom R., Diaz L. M. R., Rios V., Sola L. R., Rivera R., Robiro X. R., Roca M., Saumell C. R., Rodrigo C., Rodriguez E., Garcia M. R., Jimenez S. S., Calderon P. S., Mendez L. S., Parra S. S., Santolaya C., Sanz M. R. S., Blanco A. S., Serralvo E., Sierra N., Valero C. S., Lopez J. S., Fontanillas M. T., Riera M. T., Tobajas G., Torres C., Marques J. T., Pastor M. U., Wirdby A., Linden J., Henriksson K., Elmersson M., Egilsson A., Borjesson U., Svard G., Liu B., Lindh A., Olsson L. -B., Gustavsson M., Andersson L., Benson L., Bothin C., Hajimirsadeghi A., Kadir K., Ericsson M., Ohlsson A., Lindvall H., Svensson P., Thorne K., Handel H., Platonov P., Eriksson B., Timberg I., Romberg K., Crisby M., Karlsson J. -E., Jensen S. A., Andersson A., Malmqvist L., Martinsson B., Bernsten F., Engdahl J., Thulin J., Hot-Bjelac A., Stalby P., Aaroe H., Ahbeck E., Ahlmark H., Al-Khalili F., Bonkowski G., Dzeletovic S., Ekstrand A. -B., Eriksson G. -B., Floren K., Grassjo C., Hahn S., Jaensson P., Jansson B., Jansson J. -H., Kangert R. -M., Koch A., Kusiak D., Lettenstrom A., Lindberg A., Lindholm C. -J., Mannermyr A., Mansson K., Millborg M., Nilsson C., Ohlin A. -M., Olofsson A., Osberg A., Pedersen A., Risbecker K., Rosenberg K., Samuelsson J., Shayesteh M., Skoglund K., Stjernberg M., Thorsen C., Beer J. H., Debrunner J., Amstutz D., Bruegger J., Elise G., Grau A., Guinand A., Henriette I., Saga E., Winnik S., Rudyk I., Tseluyko V., Karpenko O., Zhurba S., Kraiz I., Kupnovytska I., Serediuk N., Mostovoy Y., Ushakov O., Koval O., Kovalskyi I., Svyshchenko Y., Sychov O., Stanislavchuk M., Kraydashenko O., Yagensky A., Tykhonova S., Fushtey I., Belegai R., Berko G., Burdeuna L., Chabanna O., Daniuk I., Ivanov A., Kamenska E., Kaplan P., Khyzhnyak O., Kizim S., Matova O., Medentseva O., Mochonyi V., Mospan M., Nemtsova V., Ovdiienko T., Palamarchuk O., Pavelko M., Petrovskyy R., Plevak D., Proshak O., Pyvovar S., Rasputina L., Romanenko O., Romanova O., Sapatyi A., Shumakov O., Stets R., Todoriuk L., Varenov V., Chauhan N., Goodwin D., Saunders P., Evans R., Leese J., Jhittay P. S., Ross A., Kainth M. S., Pickavance G., McDonnell J., Williams A., Gooding T., Wagner H., Suryani S., Singal A., Sircar S., Bilas R., Hutchinson P., Wakeman A., Stokes M., Paul N., Aziz M., Ramesh C., Wilson P., Franklin S., Fairhead S., Thompson J., St Joseph V., Taylor G., Tragen D., Seamark D., Paul C., Richardson M., Jefferies A., Sharp H., Jones H., Giles C., Page M., Oginni O., Aldegather J., Wetherwell S., Lumb W., Evans P., Scouller F., Macey N., Stipp Y., West R., Thurston S., Wadeson P., Matthews J., Pandya P., Gallagher A., Railton T., Sinha B., Russell D., Davies J. A., Ainsworth P., Jones C. P., Weeks P., Eden J., Kernick D., Murdoch W., Lumley L., Patel R. P., Wong S. W., Saigol M., Ladha K., Douglas K., Cumberlidge D. F., Bradshaw C., Van Zon G., Jones K. P., Thomas M. J., Watson E., Sarai B., Ahmad N., Willcock W., Cairns J., Sathananthan S., de Kare-Silver N., Gilliland A., Strieder E., Howitt A., Vishwanathan B., Bird N., Gray D., Clark M., Bisatt J., Litchfield J., Fisher E., Fooks T., Kelsall A. R., Alborough E., Wakeling J., Parfitt M., Milne K., Rogers S., Priyadharshan R., Oliver J. L., Davies E., Abushal S., Jacobs M., Hutton C., Walls N. I., Thompson R., Chigbo C., Zaidi S. M. A., Howard M., Butter K. C., Barrow S., Little H., Haq I. U., Gibbons L., Glencross S., McLeod A. J., Poland K., Mulholland C., Warke A., Conn P., Burns G., Smith R. N., Lowe S., Kamath R., Dau H. S., Webster J., Hodgins I., Vercoe S., Roome P. C., Pinnock H., Patel J. R. A., Ali A., Hart N., Davies R., Stuart E., Neden C. A., Danielsen M., Heath R., Sharma P., Galloway S., Hawkins C., Oliver R., Aylward M., Mannion S., Braddick M., Edwards D., Rothwell A. C., Sabir A., Choudhary F., Khalaque S., Wilson A., Peters S., Coulson W., Roberts N., Heer A., Coates S., Ward B., Jackson D., Walton S., Shepherd D., Sterry M., Wong T., Boon M., Bunney R., Haria-Shah R., Baron R. T., Davies S., Schatzberger T., Hargreaves N., Stephenson T., Choi H., Batson R., Lucraft L., Myhill T., Estifano S., Geatch D., Wilkinson J., Veale R., Forshaw K., Davies T., Zaman K., Vinson P., Liley C., Bandrapalli M., McGinty P., Wastling R., McEleny P., Beattie A., Cooke P., Wong M., Gunasegaram J., Pugsley M., Ahmad S., A'Court C., Ayers J., Bennett J., Cartwright S., Dobson S., Dooldeniya C., Flynn A., Fox R., Goram J., Halpin A., Hay A., Jacobs P., Jeffers L., Lomax L., Munro I., Muvva R., Nadaph M., Powell K., Randfield S., Redpath D., Reed R., Rickenbach M., Rogers G., Saunders P. B., Seamark C., Shewring J., Simmons P., Simper H., Stoddart H., Sword A., Thomas N., Thomson A., Blenkhorn A., Singh B., Van Gaal W., Abhayaratna W., Lehman R., Roberts-Thomson P., Kilian J., Coulshed D., Catanchin A., Colquhoun D., Kiat H., Eccleston D., French J., Zimmett L., Ayres B., Phan T., Blombery P., Crimmins D., O'Donnell D., Choi A., Astridge P., Arstall M., Jepson N., Binnekamp M., Lee A., Rogers J., Starmer G., Carroll P., Faunt J., Aggarwala A., Barry L., Batta C., Beveridge R., Black A., Bonner M., Boys J., Buckley E., Campo M., Carlton L., Connelly A., Conway B., Cresp D., Dimitri H., Dixon S., Dolman M., Duroux M., Eskandari M., Eslick R., Ferreira-Jardim A., Fetahovic T., Fitzpatrick D., Geraghty R., Gibbs J., Grabek T., Modi M. H., Hayes K., Hegde M. P., Hesketh L., Hoffmann B., Johnson K., Juergens C., Kassam I., Lawlor V., Lehman M., Lehman S., Leung D., Mackay S., MacKenzie M., McCarthy C., McIntosh C., McKeon L., Morrison H., Mussap C., Myers J. -D., Nagalingam V., Oldfield G., O'May V., Palmer J., Parsons L., Patching K., Patching T., Paul V., Plotz M., Preston S., Rashad H., Ratcliffe M., Raynes S., Rose J., Sanders L., Seremetkoska M., Setio H., Shone S., Shrestha P., Singh C., Singleton C., Stoyanov N., Sutcliffe S., Swaraj K., Tarrant J., Thompson S., Tsay I. M., Vorster M., Waldman A., Wallis L., Wilford E., Wong K., Luton R., Gupta M., Pandey A. S., Cheung S., Leader R., Beaudry P., Ayala-Paredes F., Berlingieri J., Heath J., Poirier G., Du Preez M., Nadeau R., Dresser G., Dhillon R., Hruczkowski T., Schweitzer B., Coutu B., Angaran P., MacDonald P., Vizel S., Fikry S., Parkash R., Lavoie A., Cha J., Ramjattan B., Bonet J., Ahmad K., Aro L., Aves T., Beaudry K., Bergeron C., Bigcanoe J., Bignell N., Breakwell L., Burke E., Carroll L., Clarke B., Cleveland T., Daheb S., Dehghani P., Denis I., Djaidani Z., Dorian P., Douglass S., Dunnigan J., Ewert A., Farquhar D., Fearon A., Ferleyko L., Fournier D., Fox B., Grenier M. -C., Gulliver W., Haveman K., Hines C., Hines K., Jackson A. M., Jean C., Jethoo G., Kahlon R., Kelly S., Kim R., Korley V., Kornder J., Kwan L., Largy J., Lewis C., Lewis S., Mangat I., Moor R., Navratil J., Neas I., Otis J., Otis R., Pandey M., Petrie F., Pinter A., Raines M., Roberts P., Robinson M., Sas G., Schulman S., Snell L., Spearson S., Stevenson J., Trahey T., Wong S., Wright D., El-Aziz A. A., Seif S. K. A., El Din M. G., El Etriby S., Elbahry A., El-Etreby A., Elkhadem M., Katta A., Khairy T., Mowafy A., Nawar M., Ohanissian A., Reda A., Reda M., Salem H., Sami N., Samir S., Setiha M., Sobhy M., Soliman A., Taha N., Tawfik M., Zaatout E., Kettles D., Bayat J., Siebert H., Horak A., Kelfkens Y., Garda R., Pillay T., Guerra M., van Zyl L., Theron H., Murray A., Louw R., Greyling D., Mntla P., Ueckermann V., Loghdey R., Ismail S., Ahmed F., Engelbrecht J., Ramdass A., Maharajh S., Oosthuysen W., Angel G., Bester C., Booysen M., Boshoff C., Cannon C., Cassimjee S., Chami C., Conway G., Davids A., de Meyer L., Du Plessis G., Ellis T., Henley L., Karsten M., Loyd E., Marks J., Mavhusa L., Mostert M., Page A., Rikhotso L., Salie M., Sasto J., Shaik F., Skein A., Smith L., Tarr G., Tau T., van Zyl F., Yousef G., Agrawal A., Nathani M., Ibrahim M., Esheiba E. M., Singh R., Naguib A., Abu-Mahfouz M., Al Omairi M., Al Naeemi A., Maruthanayagam R., Bazargani N., Wassef A., Gupta R., Khan M., Subbaraman B., Abdul A., Al Mulla A., El Bardisy S., Haridas P., Jadhav S., Magdaluyo K., Makdad M., Maqsood I., Mohamed R., Sharma N., Sharma R., Thanzeel M., Canosa R., Rama P., Blumberg E., Garcia J., Mullen P., Wilson V., Quick A., Ferrick K., Kutayli W. M., Cox M., Franco M., Falkowski S., Mendelson R., Williams M., Miller S., Beach S., Alfieri A., Gutowski T., Haque I., Reddy R., Ahmed W., Delafontaine P., Diercks D., Theodoro D., Remmel K., Alberts M., Ison R., Noveck H., Duffy P., Pitta S., Nishijima D., Treasure C., Asafu-Adjaye N., Ball K., Bartlett M., Bentley M., Bowers S., Brown A., Browne A., Cameron-Watts J., Canova M., Cassidy D., Cervellione K., Congal S., DePauw J., Dickerson A., Eley M., Evans L., Felpel S., Ferdinand K., Fielder D., Gentry P., Haideri A., Hakimi F., Harbour T., Hartranft E., Hawkins B., Headlee M., Henson L., Herrick C., Hicks T., Jasinski S., Jones A., Jones L., Jones P., Karl S., Keeling M., Kerr J., Knowles P., Langdon J., Lay M., Lee J. A., Lincoln T., Malone E., Merliss A., Merritt D., Minardo J., Mooso B., Orosco C., Palumbo V., Parker M., Parrott T., Paserchia S., Pearl G., Peterson J., Pickelsimer N., Purcell T., Raynor J., Raziano S., Richard C., Richardson T., Robertson C., Sage A., Sanghera T., Shaw P., Shoemaker J., Smith K., Stephanie B., Thatcher A., Theobald H., Thompson N., Treasure L., Tripti T., Verdi C., Worthy V., Jerjes-Sanchez, C, Corbalan, R, Barretto, A, Luciardi, H, Allu, J, Illingworth, L, Pieper, K, Kayani, G, Fitzmaurice, D, Goto, S, Hacke, W, Mantovani, L, Turpie, A, Gersh, B, Gibbs, H, Brodmann, M, Cools, F, Connolly, S, Spyropoulos, A, Eikelboom, J, Hu, D, Jansky, P, Nielsen, J, Ragy, H, Raatikainen, P, Le Heuzey, J, Darius, H, Keltai, M, Kakkar, S, Sawhney, J, Agnelli, G, Ambrosio, G, Koretsune, Y, Diaz, C, ten Cate, H, Atar, D, Stepinska, J, Panchenko, E, Lim, T, Jacobson, B, Oh, S, Vinolas, X, Rosenqvist, M, Steffel, J, Angchaisuksiri, P, Parkhomenko, A, Al Mahmeed, W, Chen, K, Zhao, Y, Zhang, H, Chen, J, Cao, S, Wang, D, Yang, Y, Li, W, Yin, Y, Tao, G, Yang, P, Chen, Y, He, S, Wang, Y, Fu, G, Li, X, Wu, T, Cheng, X, Yan, X, Zhao, R, Chen, M, Xiong, L, Chen, P, Jiao, Y, Guo, Y, Xue, L, Wang, F, Li, H, Yang, Z, Bai, C, Chen, X, Feng, S, Fu, Q, Gao, X, Guo, W, He, R, He, X, Hu, X, Huang, X, Li, B, Li, J, Li, L, Li, Y, Liu, T, Liu, W, Liu, Y, Lu, Z, Luo, X, Ma, T, Peng, J, Sheng, X, Shi, X, Sun, Y, Tian, G, Wang, K, Wang, L, Wu, R, Xie, Q, Xu, R, Yang, J, Yang, L, Yang, Q, Ye, Y, Yu, H, Yu, J, Yu, T, Zhai, H, Zhan, Q, Zhang, G, Zhang, Q, Zhang, R, Zhang, Y, Zheng, W, Zhou, B, Zhou, Z, Zhu, X, Jadhav, P, Durgaprasad, R, Ravi Shankar, A, Rajput, R, Bhargava, K, Sarma, R, Srinivas, A, Roy, D, Nagamalesh, U, Chopda, M, Kishore, R, Kulkarni, G, Chandwani, P, Pothiwala, R, Padinhare Purayil, M, Shah, S, Chawla, K, Kothiwale, V, Raghuraman, B, Vijayaraghavan, G, Vijan, V, Bantwal, G, Bisne, V, Khan, A, Gupta, J, Kumar, S, Jain, D, Abraham, S, Adak, D, Barai, A, Begum, H, Bhattacharjee, P, Dargude, M, Davies, D, Deshpande, B, Dhakrao, P, Dhyani, V, Duhan, S, Earath, M, Ganatra, A, Giradkar, S, Jain, V, Karthikeyan, R, Kasala, L, Kaur, S, Krishnappa, S, Lawande, A, Lokesh, B, Madarkar, N, Meena, R, More, P, Naik, D, Prashanth, K, Rao, M, Rao, N, Sadhu, N, Shah, D, Sharma, M, Shiva, P, Singhal, S, Suresh, S, Vanajakshamma, V, Panse, S, Kanamori, S, Yamamoto, K, Kumagai, K, Katsuda, Y, Sadamatsu, K, Toyota, F, Mizuno, Y, Misumi, I, Noguchi, H, Ando, S, Suetsugu, T, Minamoto, M, Oda, H, Shiraishi, K, Adachi, S, Chiba, K, Norita, H, Tsuruta, M, Koyanagi, T, Ando, H, Higashi, T, Okada, K, Azakami, S, Komaki, S, Kumeda, K, Murayama, T, Matsumura, J, Oba, Y, Sonoda, R, Goto, K, Minoda, K, Haraguchi, Y, Suefuji, H, Miyagi, H, Kato, H, Nakamura, T, Nandate, H, Zaitsu, R, Fujiura, Y, Yoshimura, A, Numata, H, Ogawa, J, Tatematsu, H, Kamogawa, Y, Murakami, K, Wakasa, Y, Yamasawa, M, Maekawa, H, Abe, S, Kihara, H, Tsunoda, S, Saito, K, Fudo, T, Obunai, K, Tachibana, H, Oba, I, Kuwahata, T, Higa, S, Gushiken, M, Eto, T, Yoshida, H, Ikeda, D, Ishizawa, M, Nakatsuka, M, Murata, K, Ogurusu, C, Shimoyama, M, Akutsu, M, Takamura, I, Hoshino, F, Yokota, N, Iwao, T, Tsuchida, K, Takeuchi, M, Hatori, Y, Kitami, Y, Nakamura, Y, Oyama, R, Ageta, M, Go, Y, Mishima, K, Unoki, T, Morii, S, Shiga, Y, Sumi, H, Nagatomo, T, Sanno, K, Fujisawa, K, Atsuchi, Y, Nagoshi, T, Seto, T, Tabuchi, T, Kameko, M, Nii, K, Oshiro, K, Takezawa, H, Nagano, S, Miyamoto, N, Iwaki, M, Fujii, M, Okawa, M, Abe, M, Saito, T, Mito, T, Nagao, K, Minami, J, Mita, T, Sakuma, I, Taguchi, T, Marusaki, S, Doi, H, Tanaka, M, Fujito, T, Matsuta, M, Kusumoto, T, Kakinoki, S, Ashida, K, Yoshizawa, N, Agata, J, Arasaki, O, Manita, M, Ikemura, M, Fukuoka, S, Murakami, H, Matsukawa, S, Hata, Y, Taniguchi, T, Ko, T, Kubo, H, Imamaki, M, Akiyama, M, Inagaki, M, Odakura, H, Ueda, T, Katsube, Y, Nakata, A, Watanabe, H, Techigawara, M, Igarashi, M, Taga, K, Kimura, T, Tomimoto, S, Shibuya, M, Nakano, M, Ito, K, Seo, T, Hiramitsu, S, Hosokawa, H, Hoshiai, M, Hibino, M, Miyagawa, K, Horie, H, Sugishita, N, Soma, A, Neya, K, Yoshida, T, Mizuguchi, M, Ishiguro, M, Minagawa, T, Wada, M, Mukawa, H, Okuda, F, Nagasaka, S, Abe, Y, Adachi, T, Akahane, K, Amano, T, Aoki, K, Aoyama, T, Arai, H, Arima, S, Arino, T, Asano, H, Asano, T, Azuma, J, Baba, T, Betsuyaku, T, Chibana, H, Date, H, Doiuchi, J, Emura, Y, Endo, M, Fujii, Y, Fujiki, R, Fujisawa, A, Fujisawa, Y, Fukuda, T, Fukui, T, Furukawa, N, Furukawa, T, Furumoto, W, Goto, T, Hamaoka, M, Hanazono, N, Hasegawa, K, Hatsuno, T, Hayashi, Y, Higuchi, K, Hirasawa, K, Hirayama, H, Hirose, M, Hirota, S, Honda, M, Ido, T, Iiji, O, Ikeda, H, Ikeda, K, Ikeoka, K, Imaizumi, M, Inaba, H, Inoue, T, Iseki, F, Ishihara, A, Ishioka, N, Ito, N, Iwase, T, Kakuda, H, Kamata, J, Kanai, H, Kanda, H, Kaneko, M, Kano, H, Kasai, T, Kato, T, Kato, Y, Kawada, Y, Kawai, K, Kawakami, K, Kawakami, S, Kawamoto, T, Kawano, S, Kim, J, Kira, T, Kitazawa, H, Kitazumi, H, Kito, T, Kobayashi, T, Koeda, T, Kojima, J, Komatsu, H, Komatsu, I, Koshibu, Y, Kotani, T, Kozuka, T, Kumai, Y, Kumazaki, T, Maeda, I, Maeda, K, Maruyama, Y, Matsui, S, Matsushita, K, Matsuura, Y, Mineoi, K, Mitsuhashi, H, Miura, N, Miyaguchi, S, Miyajima, S, Miyamoto, H, Miyashita, A, Miyata, S, Mizuguchi, I, Mizuno, A, Mori, T, Moriai, O, Morishita, K, Murai, O, Nagai, S, Nagata, E, Nagata, H, Nakagomi, A, Nakahara, S, Nakamura, M, Nakamura, R, Nakanishi, N, Nakayama, T, Nakazato, R, Nanke, T, Nariyama, J, Niijima, Y, Niinuma, H, Nishida, Y, Nishihata, Y, Nishino, K, Nishioka, H, Nishizawa, K, Niwa, I, Nomura, K, Nomura, S, Nozoe, M, Ogawa, T, Ohara, N, Okada, M, Okamoto, K, Okita, H, Okuyama, M, Ono, H, Ono, T, Pearce, Y, Oriso, S, Ota, A, Otaki, E, Saito, Y, Sakai, H, Sakamoto, N, Sakamoto, Y, Samejima, Y, Sasagawa, Y, Sasaguri, H, Sasaki, A, Sasaki, T, Sato, K, Sawano, M, Seki, S, Sekine, Y, Seta, Y, Sezaki, K, Shibata, N, Shiina, Y, Shimono, H, Shimoyama, Y, Shindo, T, Shinohara, H, Shinohe, R, Shinozuka, T, Shirai, T, Shiraiwa, T, Shozawa, Y, Suga, T, Sugimoto, C, Suzuki, K, Suzuki, S, Suzuki, Y, Tada, M, Taguchi, A, Takagi, T, Takagi, Y, Takahashi, K, Takahashi, S, Takai, H, Takanaka, C, Take, S, Takeda, H, Takei, K, Takenaka, K, Tana, T, Tanabe, G, Taya, K, Teragawa, H, Tohyo, S, Toru, S, Tsuchiya, Y, Tsuji, T, Tsuzaki, K, Uchiyama, H, Ueda, O, Ueyama, Y, Wakaki, N, Wakiyama, T, Washizuka, T, Watanabe, M, Yamada, T, Yamagishi, T, Yamaguchi, H, Yamamoto, T, Yamaura, M, Yamazoe, M, Yasui, K, Yokoyama, Y, Yoshida, K, Ching, C, Foo, C, Chow, J, Chen, D, Jaufeerally, F, Lee, Y, Lim, G, Lim, W, Thng, S, Yap, S, Yeo, C, Pak, H, Jang, S, Kim, D, Ryu, D, Park, S, Choi, D, Oh, Y, Cho, M, Kim, S, Jeon, H, Shin, D, Park, J, Park, H, Han, S, Sung, J, Cho, J, Nam, G, On, Y, Lim, H, Kwak, J, Cha, T, Hong, T, Yoon, J, Kim, N, Kim, K, Jung, B, Hwang, G, Kim, C, Ahn, J, An, H, Bae, H, Baek, A, Chi, W, Choi, E, Choi, H, Heo, E, Her, K, Hwang, S, Jang, E, Jang, H, Jeon, S, Jeon, Y, Jeong, H, Jung, I, Kim, H, Kim, M, Kim, Y, Lee, C, Lee, E, Lee, G, Lee, H, Lee, K, Lee, M, Lee, R, Lee, S, Lee, W, Noh, I, Park, A, Park, B, Park, M, Park, Y, Seo, S, Shim, J, Sim, J, Sohn, Y, Son, W, Son, Y, Song, H, Wi, H, Woo, J, Ye, S, Yim, K, Yoo, K, Yoon, E, Yun, S, Chawanadelert, S, Mongkolwongroj, P, Kanokphatcharakun, K, Cheewatanakornkul, S, Laksomya, T, Pattanaprichakul, S, Chantrarat, T, Rungaramsin, S, Silaruks, S, Wongcharoen, W, Siriwattana, K, Likittanasombat, K, Katekangplu, P, Boonyapisit, W, Cholsaringkarl, D, Chatlaong, B, Chattranukulchai, P, Santanakorn, Y, Hutayanon, P, Khunrong, P, Bunyapipat, T, Jai-Aue, S, Kaewsuwanna, P, Bamungpong, P, Gunaparn, S, Hongsuppinyo, S, Inphontan, R, Khattaroek, R, Khunkong, K, Kitmapawanont, U, Kongsin, C, Naratreekoon, B, Ninwaranon, S, Phangyota, J, Phrommintikul, A, Phunpinyosak, P, Pongmorakot, K, Poomiphol, S, Pornnimitthum, N, Pumprueg, S, Ratchasikaew, S, Sanit, K, Sawanyawisuth, K, Silaruks, B, Sirichai, R, Sriwichian, A, Suebjaksing, W, Sukklad, P, Suttana, T, Tangsirira, A, Thangpet, O, Tiyanon, W, Vorasettakarnkij, Y, Wisaratapong, T, Wongtheptien, W, Wutthimanop, A, Yawila, S, Altun, A, Ozdogru, I, Ozdemir, K, Yilmaz, O, Aydinlar, A, Yilmaz, M, Yeter, E, Ongen, Z, Cayli, M, Pekdemir, H, Ozdemir, M, Sucu, M, Sayin, T, Demir, M, Yorgun, H, Ersanli, M, Okuyan, E, Aras, D, Abdelrahman, H, Aktas, O, Alpay, D, Aras, F, Bireciklioglu, M, Budeyri, S, Buyukpapuc, M, Caliskan, S, Esen, M, Felekoglu, M, Genc, D, Ikitimur, B, Karaayvaz, E, Karatas, S, Okutucu, S, Ozcelik, E, Quisi, A, Sag, H, Sahiner, L, Sayin, B, Seker, T, Alkan, D, Yildirim, E, Yildirim, R, Yilmaz, F, Yuksekdag, V, Vensentini, N, Ingaramo, A, Sambadaro, G, Caputi, V, Berman, S, Dragotto, P, Kleiban, A, Centurion, N, Giacomi, G, Guerrero, R, Conde, D, Zapata, G, Di Paola, L, Ramos, J, Dran, R, Egido, J, Fernandez, A, Fosco, M, Sassone, S, Sinisi, V, Cartasegna, L, Berli, M, Vilamajo, O, Ferroni, F, Alaguibe, E, D'Amelio, A, Arabetti, C, Arias, L, Belardi, J, Bergesio, L, Berli, F, Borchowiec, S, Buzzetti, C, Cabrini, R, Campisi, V, Cappi, A, Carrizo, R, Berra, F, Costabel, J, Costamagna, O, Damonte, A, De Urquiza, I, Diez, F, Eden, M, Fanuele, M, Voena, F, Torres, M, Funosas, C, Giacomi, M, Gimenez, C, Gurfinkel, E, Had, M, Hansen, V, Hrabar, A, Ingratta, M, Lopez, A, Maehara, G, Maffei, L, Martinelli, A, Martinelli, C, Matkovich, J, Mautner, B, Meirino, A, Munguia, R, Navarro, A, Novas, V, Prados, G, Pontoriero, J, Potito, R, Ricotti, C, Rodriguez, M, Rolandi, F, Palladino, M, Salinger, M, Sanziani, L, Schygiel, P, Sossich, A, Tinto, J, Tonelli, L, Tufare, A, Vallejo, M, Yunis, M, Zillo, M, Zurbrigk, F, Filho, D, Jaber, J, Armaganijan, D, Neto, J, Steffens, A, de Souza, W, de Souza Neto, J, Ribeiro, J, Teixeira, M, Rossi, P, Pires, L, Moreira, D, Jorge, J, Filho, A, Bodanese, L, Montera, M, Del Carlo, C, Rodrigues, T, da Costa, F, Lopes, A, Lopes, R, Araujo, G, Manenti, E, Saraiva, J, Braga, J, Negri, A, Souto, L, Moncada, C, Precoma, D, Roquette, F, Reis, G, Filho, R, Figueiredo, E, Botelho, R, Tavares, C, Frack, C, Saad, J, Finimundi, H, Pisani, C, Chemello, D, Martins, M, Franca, C, Alban, F, Rosito, G, Moraes Junior, J, Tumelero, R, Maia, L, de Almeida, R, do Carmo Borges, N, Ferreira, L, Agliardi, P, Gomes, J, Araujo, V, Nakazone, M, Barbosa, T, Barroso, S, Falchetto, E, Lopes, H, Lemos, M, Biazus, G, Queiroz, L, Camazzola, F, Caporale, M, Cardoso Boscato, S, Chieza, F, Chokr, M, Mingireanov, R, Goes, N, Correa, C, Costa, M, Ortiz, C, da Silva, L, Paulitsch, F, da Silveira, J, Daros, E, de Araujo, G, Del Monaco, M, Dias, C, Dias, M, Wainstein, A, Pizzato, P, Esteves, D, Fabri, P, Fonseca, T, Fernandes, E, Fonseca, C, Costantini, C, Ferraz, R, Freire, F, Gottardo, P, Guanaes, D, Guizzardi, S, Magedanz, E, Igansi, F, Jannuzzi, F, Junior, G, Komar, D, Lino, E, Lopes, D, Junior, O, Lustosa, E, Macagnan, A, Marinho, M, Mazzoni, M, Melo, G, Mortari, L, Mouco, O, Vital, C, Ormundo, C, Emmer, S, Palmegiani, E, Pavani, R, Pereira, L, Pereira, V, Perreira, R, Poletti, S, Fortunato, S, Queirantes, C, Pereira, N, Rech, R, Ribeiro, S, Rodrigues, A, Roesch, H, Reichert, T, Santos, D, Santos, I, Santos, M, Seroqui, M, Silva, S, Soares, L, Spolaor, L, Stoll, C, Duda, N, Trama, L, Unterkircher, B, Valois, M, Vargas, T, Viana, T, Vicente, C, Armaganijan, L, Homem, R, Torres, L, Vila, L, Filho, F, Eggers, G, Gutierrez, C, Arriagada, G, Cardenas, S, Fernandez, B, Conejeros, C, Houzvic, C, Cuevas, P, Montecinos, H, Forero, A, Lanas, F, Gomez, M, Vilches, G, Rey, C, Astudillo, C, Aguilar, J, Campisto, Y, Lara, C, Molina, E, Oyarzon, J, Olguin, V, Vergara, M, Villan, C, Diaz, J, Cantu, R, Zavala, M, Jardines, R, Zavaleta, N, Umana, S, Rosas, E, Esperon, G, Pozas, G, Munoz, E, Hernandez, N, Rendon, A, Ibarra, M, Carrillo, L, Villezca, D, Herrera, C, Prieto, J, Rodriguez, R, Espinosa, E, Martinez, D, Barcena, J, Yong, R, Briones, I, Pons, J, Lopez, H, Ruiz, R, de la Vega, C, Brito, C, Valenzuela, E, Reyes-Sanchez, R, Ruiz, A, Flores, O, Gonzalez, M, Nava, R, Cerda, J, Fierro, O, Campos, P, Alfaro, T, Bellorin, S, Avena, R, Chavarria, M, Espinosa, I, Silva, F, Godoy, K, Felix, E, Garcia, C, Salas, L, Guajardo, P, Gonzalez, S, Izquierdo, T, Ortiz, M, Vasquez, D, Mendoza, N, Morales, J, Nikitina, N, Aybar, S, Ortiz, A, Macias, P, Perez, F, Sanchez, J, Toledano, S, Ramos, C, Castro, V, Cardona, G, Cornejo, M, Salinas, A, Santana, G, Perez, P, Castaneda, A, Cortes, R, Lenz, K, Drexel, H, Foechterle, J, Hagn, C, Podczeck-Schweighofer, A, Huber, K, Winkler, M, Schneeweiss, B, Gegenhuber, A, Lang, W, Eichinger-Hasenauer, S, Kaserer, P, Sykora, J, Rasch, H, Pichler, M, Schaflinger, E, Strohmer, B, Breier, R, Ebner, K, Eischer, L, Freihoff, F, Lischka-Lindner, A, Mark, T, Mirtl, A, Said, A, Stocklocker, C, Vogel, B, Vonbank, A, Wohrer, C, Zanolin, D, Paparella, G, Vandergoten, P, Parque, J, Capiau, L, Vervoort, G, Wollaert, B, Desfontaines, P, Mairesse, G, Boussy, T, Godart, P, De Wolf, A, Voet, J, Heyse, A, Hollanders, G, Anne, W, Vercammen, J, Purnode, P, Blankoff, I, Faes, D, Balthazar, Y, Beutels, M, Marechal, P, Verstraete, S, Xhaet, O, Striekwold, H, Thoeng, J, Hermans, K, Alzand, B, Ascoop, A, Banaeian, F, Barbuto, A, Billiaux, A, Blockmans, M, Bouvy, C, Brike, C, Capiau, H, Casier, T, Bolado, A, De Cleen, D, De Coninck, M, de Vos, M, de Weerdt, N, Delforge, M, Delvigne, M, Denie, D, Derycker, K, Deweerd, E, Dormal, F, Drieghe, S, Everaert, M, Eykerman, T, Feys, E, Ghekiere, M, Gits, F, Hellemans, S, Helvasto, L, Jacobs, C, Lips, S, Mestdagh, I, Nimmegeers, J, Piamonte, V, Pollet, P, Postolache, A, Raepers, M, Raymenants, E, Richa, J, Rombouts, H, Salembier, J, Scheurwegs, C, Semeraro, O, Simons, N, Smessaert, C, Smolders, W, Stockman, I, Tahon, S, Thyssen, V, Tincani, G, Van Durme, F, Van Lier, D, Vandekerckhove, H, Vandekerckhove, Y, Vandenbroeck, D, Vandorpe, A, Vanhalst, E, Vanhauwaert, B, Vantomme, C, Vergauwen, L, Verloove, H, Vydt, T, Weyn, T, Reichert, P, Spacek, R, Machova, V, Zidkova, E, Ludka, O, Olsr, J, Kotik, L, Plocova, K, Racz, B, Ferkl, R, Hubac, J, Kotik, I, Monhart, Z, Burianova, H, Jerabek, O, Pisova, J, Petrova, I, Dedek, V, Honkova, M, Podrazil, P, Spinar, J, Vitovec, J, Novak, M, Lastuvka, J, Durdil, V, Antonova, P, Bockova, L, Bultas, J, Chlumsky, J, Dastychova, L, Drasnar, T, Honek, J, Horejsi, M, Hubacova, V, Janska, L, Kopeckova, I, Kratochvilova, R, Krcova, E, Labrova, R, Lindourkova, A, Lipoldova, J, Lubanda, H, Ludkova, A, Mahdalikova, L, Majernikova, M, Michalik, D, Potuznik, P, Prochazkova, E, Sulc, A, Sveceny, J, Valtova, M, Zidek, M, Zika, J, Nielsen, H, Husted, S, Hintze, U, Rasmussen, S, Bremmelgaard, A, Markenvard, J, Boerger, J, Solgaard, J, Simonsen, P, Loekkegaard, T, Bruun, M, Mertz, J, Dominguez, H, Skagen, K, Egstrup, K, Ibsen, H, Raymond, I, Bang-Hansen, T, Ellervik, C, Eriksen, E, Jensen, L, Jensen, M, Leth, M, Nygaard, A, Schou, M, Therkelsen, A, Tilma, J, Vesterager, K, Airaksinen, J, Arola, O, Koistinen, J, Nappila, H, Peltomaki, K, Rasanen, V, Vasankari, T, Galinier, M, Gottwalles, Y, Paganelli, F, Loiselet, P, Muller, J, Koujan, M, Marquand, A, Destrac, S, Piot, O, Delarche, N, Cebron, J, Boveda, S, Guenoun, M, Guedj-Meynier, D, Galley, D, Ohayon, J, Assouline, S, Zuber, M, Amarenco, P, Ellie, E, Kadouch, J, Fournier, P, Huberman, J, Lemaire, M, Rodier, G, Milandre, L, Vandamme, X, Sibon, I, Neau, J, Mahagne, M, Mielot, A, Bonnefoy, M, Churet, J, Navarre, V, Sellem, F, Monniot, G, Boyes, J, Doucet, B, Martelet, M, Obadia, D, Crousillat, B, Mouallem, J, Bearez, E, Nazeyrollas, P, Brugnaux, J, Fedorowsky, A, Casassus, F, Berneau, J, Chemin, F, Falvo, N, Perron, J, Poulard, J, Barreau, A, Beltra, C, Corrihons, E, Decarsin, N, Dubois, B, Ducasse, E, Giry, X, Kemmel, A, Ledure, S, Lemaire, N, Robin, F, Rosolin, N, Sanchez, D, Suissa, A, Koniger, G, Purr, J, Gerbaulet, U, Kellner, B, Kopf, A, Schafer, T, Zauzig, H, Riegel, P, Hohensee, H, Eissfeller, E, Eder, W, Rehling, G, Glatzel, D, Zutz, S, Heinz, G, Menke, H, Pustelnik, A, Sandow, P, Ludwig, N, Wiswedel, H, Wildenauer, W, Axthelm, C, Schwarz, T, Babyesiza, A, Stuchlik, G, Zimny, H, Kropp, M, Kahl, F, Caspar, A, Omankowsky, S, Lassig, T, Hartmann, H, Lehmann, G, Bindig, H, Hergdt, G, Reimer, D, Hauk, J, Dorsch, W, Dshabrailov, J, Michel, H, Rapp, K, Vormann, R, Mayer, P, Horstmeier, U, Eissing, V, Hey, H, Leuchtgens, H, Lilienweiss, V, Kolitsch, K, Schubert, C, Lauer, H, Buchner, T, Brauer, G, Kamin, S, Muller, K, Abdel-Qader, M, Baumbach, S, Ebert, H, Schwencke, C, Schellong, S, Bernhardt, P, Karolyi, L, Sievers, B, Haverkamp, W, Salbach, P, Rohnisch, J, Schoen, S, Erdle, W, Mueller, T, Mueller, H, Mitrovic, V, Babjakova, Z, Bergner, K, Boehme, S, Bonin, K, Buckert, D, Busch, F, Dichristin, U, Diez, S, Fleck, A, Flint, K, Floegel, H, Fritz, C, Frommhold, R, Gehre, J, Geyer, J, Grytzmann, A, Hahn, M, Helgert, K, Hubert, K, Kirchner-Volker, K, Klein, V, Kroll, D, Krueger, A, Lehmann, R, Mann, L, Maselli, A, Menken, G, Mikes, K, Mortan, H, Nasser, N, Nicolaus, D, Plauskat, A, Pomper, L, Quietzsch, A, Ravenhorst, C, Reichelt, C, Reimer, C, Schaefer, B, Scharrer, S, Schirmer, K, Schmidt, K, Schoene, R, Schulze, J, Schuppe, M, Simon, S, Sommer, S, Spranger, K, Talkenberger, A, Tauber, K, Tetlak, A, Toennishoff, T, Voelkel-Babyesiza, R, Voigts, B, Weiser, U, Wesendorf, S, Wildenauer, S, Wolf, T, Wurziger, J, Zak, J, Ziefle, S, Zincke, S, Vangel, S, Szalai, G, Merkely, B, Kancz, S, Boda, Z, Nagy, A, Laszlo, Z, Matoltsy, A, Gaszner, B, Polgar, P, Habon, T, Noori, E, Juhasz, G, Kanakaridisz, N, Szentpeteri, I, Juhasz, F, Vertes, A, Papp, A, May, Z, Ferenczi, J, Egyutt, M, Kis, E, Engelthaler, G, Szantai, G, Fulop, E, Gombos, P, Gulyas, D, Jen, P, Kiralyhazine Gyorke, E, Kovacs, M, Kovacsne Levang, S, Marianna, S, Radics, Z, Sydo, N, Szalo, R, Szilagyi, A, Sztanyik, F, Vandrus, B, Tiraferri, E, Santoro, R, Testa, S, Di Minno, G, Moia, M, Caimi, T, Martini, G, Tessitori, M, Cappelli, R, Poli, D, Quintavalla, R, Melone, F, Cosmi, F, Pizzini, A, Piseddu, G, Fanelli, R, Latella, C, Santi, R, Pancaldi, L, De Cristofaro, R, Palareti, G, De Blasio, A, Salerno Uriarte, J, Minetti, F, Pogliani, E, Lonati, L, Accogli, M, Ciampani, N, Malengo, S, Feola, M, Raisaro, A, Fattore, L, Grilli, P, Germini, F, Settimi, M, Alunni, M, Duranti, G, Tedeschi, L, Baglioni, G, Avanzino, G, Berardi, M, Pannacci, V, Giombolini, A, Nicoli, S, Scarponi, T, Allasia, B, Ricciarini, P, Nasorri, R, Argena, A, Bossolasco, P, Ronchini, P, Filippi, A, Tradati, F, Bulla, C, Donzelli, L, Foppa, L, Bottarelli, M, Tomasello, A, Mauric, A, Femiano, C, Reggio, R, Lillo, F, Mariani, A, Forcignano, F, Volpe, M, D'Avino, M, Bongiorni, M, Severi, S, Capucci, A, Lodigiani, C, Salomone, E, Serviddio, G, Tondo, C, Golino, P, Mazzone, C, Iacopino, S, Pengo, V, Galvani, M, Moretti, L, Ambrosino, P, Banfi, E, Biagioli, V, Bianchi, A, Boggian, G, Breschi, M, Brusorio, S, Calcagnoli, F, Campagna, G, Carpenedo, M, Ciabatta, C, Ciliberti, G, Cimmino, G, D'Arienzo, C, Di Gennaro, L, Fedele, M, Ferrini, P, Granzow, K, Guazzaloca, G, Guerra, F, Lo Buglio, A, Longo, S, Macellari, F, Mesolella, E, Mollica Poeta, E, Occhilupo, P, Oriana, V, Rangel, G, Salomone, L, Scaccianoce, A, Scarone, C, Segreti, L, Sottilota, G, Villani, R, Zecca, C, Ruiter, J, Klomps, H, Bongaerts, M, Pieterse, M, Guldener, C, Herrman, J, Lochorn, G, Lucassen, A, Adriaansen, H, The, S, Nierop, P, Hoogslag, P, Hermans, W, Groenemeijer, B, Terpstra, W, Buiks, C, Boersma, L, Boersma-Slootweg, M, Bosman, F, Bosschaert, M, Bruin, S, Danse, I, De Graaf, J, de Graauw, J, Debordes, M, Dols, S, Geerlings, F, Gorrebeeck, K, Jerzewski, A, Jetten, W, Kelderman, M, Kloosterman, T, Koomen, E, Krikken, J, Melman, P, Mulder, R, Pronk, A, Stallinga-de Vos, A, te Kaat, J, Tonino, P, Uppelschoten, B, van de Loo, R, van der Kley, T, van Leeuwen, G, van Putten, J, Westerman, L, Berge, E, Sirnes, P, Gjertsen, E, Hole, T, Erga, K, Hallaraker, A, Skjelvan, G, Ostrem, A, Ghezai, B, Svilaas, A, Christersson, P, Oien, T, Hoegh Henrichsen, S, Berg-Johansen, J, Otterstad, J, Antonsen, H, Ausen, K, Claussen, H, Dominguez, I, Jekthammer, A, Lensebraaten, A, Nilsen, V, O'Donovan, M, Ringdalen, K, Strand, S, Korzeniak, R, Gieroba, A, Biedrzycka, M, Ogorek, M, Wozakowska-Kaplon, B, Loboz-Grudzien, K, Kosior, J, Supinski, W, Kuzniar, J, Zaluska, R, Hiczkiewicz, J, Swiatkowska-Byczynska, L, Kucharski, L, Gruchala, M, Minc, P, Olszewski, M, Kania, G, Krzciuk, M, Lajkowski, Z, Ostrowska-Pomian, B, Lewczuk, J, Zinka, E, Karczmarczyk, A, Chmielnicka-Pruszczynska, M, Trusz-Gluza, M, Opolski, G, Bronisz, M, Glanowska, G, Ruszkowski, P, Jaworska, K, Sciborski, R, Okopien, B, Kukla, P, Wozniak-Skowerska, I, Galbas, K, Cymerman, K, Jurowiecki, J, Miekus, P, Myszka, W, Mazur, S, Lysek, R, Baszak, J, Rusicka-Piekarz, T, Raczak, G, Domanska, E, Nessler, J, Lesnik, J, Ambicka, M, Andrzejewski, D, Araminowicz, J, Barszcz, A, Bartkowiak, R, Bartnik, J, Basiak, M, Bekieszczuk, E, Bernat, L, Biedrzycki, L, Biernacka, A, Blaszczyk, D, Broton, E, Brzozowski, W, Brzustowska, M, Bzymek, R, Chmielowski, A, Chojnowski, P, Cichomski, R, Cieslak, K, Cieszynska, A, Curyllo, B, Czamara, M, Danilowicz-Szymanowicz, L, Dolecka, B, Drelich, L, Dudzik-Richter, B, Dybala, T, Dziuba, M, Faron, W, Figura-Chmielewska, M, Frankiewicz, A, Gadzinski, W, Gasior, E, Gosciniecka, B, Gutknecht, P, Guziewicz, M, Jackun-Podlesna, A, Jaguszewska, G, Jankielewicz, J, Jaremczuk-Kaczmarczyk, A, Jargiello-Baszak, M, Jarzebowski, A, Jaskulska-Niedziela, E, Jaworska-Drozdowska, M, Kabat, J, Kaczmarzyk-Radka, A, Kalin, K, Kaliszczak, R, Kiliszek, M, Klata, M, Kluczewski, M, Kobielusz-Gembala, I, Kochanska, E, Kociolek, D, Kolodzinska, A, Komlo, A, Konopka, A, Korczowska, E, Kowal, E, Kowalczyk, H, Kremis, E, Kruczyk, D, Krzesiak-Lodyga, A, Krzyzanowski, M, Kurdzielewicz, W, Kustrzycka-Kratochwil, D, Lesniewska-Krynska, D, Leszczynski, J, Lewicka, E, Lichota, E, Lip, K, Loboz-Rudnicka, M, Luka, J, Lysek-Jozefowicz, A, Machnikowska, M, Majewska, K, Mariankowski, R, Markiewicz, A, Mazur, M, Metzgier-Gumiela, A, Miedlar, E, Mielcarek, M, Neubauer-Geryk, J, Niedek, J, Niemirycz-Makurat, A, Nowak, A, Nowak, S, Opielowska-Nowak, B, Ozgowicz, M, Pawelska-Buczen, A, Pawlik-Rak, E, Piotrowicz, R, Ptaszynski, P, Raczynska, A, Rogowski, W, Romanek, J, Romaszkiewicz, R, Rostoff, P, Roszczyk, N, Rozewska-Furmanek, D, Rychta, J, Rzyczkowska, B, Sidor, A, Skalska, J, Smichura, M, Splawski, M, Staneta, P, Staniszewska, E, Starak-Marciniak, J, Stopyra-Poczatek, M, Sukiennik-Kujawa, M, Szafranski, J, Szalecki, P, Szczepanska, A, Szkrobka, W, Szuchnik, E, Szulowska, A, Szumczyk-Muszytowska, G, Szwoch, M, Traczyk, T, Troszczynska, M, Trzcinski, G, Tybura, S, Walasik, P, Wegrzynowska, M, Wesolowska, K, Wieczorek, W, Wierzbicka, A, Wilczewski, P, Wilgat-Szecowka, M, Wojewoda, P, Wojnowski, L, Wrobel, M, Zakutynska-Kowalczyk, K, Zyczynska-Szmon, M, Eltishcheva, V, Libis, R, Tereshchenko, S, Popov, S, Kamalov, G, Belenky, D, Zateyshchikova, A, Kropacheva, E, Kolesnikova, A, Nikolaev, K, Egorova, L, Khokhlov, A, Yakupov, E, Poltavskaya, M, Zateyshchikov, D, Drapkina, O, Vishnevsky, A, Barbarash, O, Miller, O, Aleksandrova, E, Chizhov, P, Sergeev, M, Shutemova, E, Mazur, E, Zrazhevskiy, K, Novikova, T, Kostenko, V, Moiseeva, Y, Polkanova, E, Sobolev, K, Rossovskaya, M, Zubeeva, G, Shapovalova, Y, Nagibovich, O, Edin, A, Agakhanyan, A, Batalov, R, Belenkova, Y, Bitakova, F, Chugunnaya, S, Dumikyan, A, Erofeeva, S, Gorbunova, E, Gorshkova, T, Gubanov, A, Gurmach, M, Ivanova, Y, Kolesova, T, Konyushenko, D, Korneeva, O, Kropova, O, Kuchuk, P, Kungurtseva, O, Kupriyanova, T, Kurylo, B, Kuvanova, M, Lebedeva, O, Lileeva, E, Machilskaya, O, Medvedeva, T, Monako, G, Motylev, I, Nagibovich, G, Novikova, E, Orlov, Y, Osmolovskaya, Y, Ovsannikova, A, Platonov, D, Rachkova, S, Sinitsina, O, Speshilova, S, Suslova, O, Ushakov, A, Volodicheva, O, Zemlianskaia, O, Zhirov, I, Zhuravleva, E, Zotova, I, Garcia, P, Fernandez, M, Tercedor, L, Iparraguirre, S, Monserrat, P, Contreras, E, Rafecas, J, Carrasco, J, Pavia, P, Pajuelo, C, Serrano, C, Alonso, L, Klein, J, Juanatey, J, Esquivias, G, Collado, I, Piquero, H, Cuixart, C, Morato, M, Llibre, J, Gutierrez, M, Gonzalo, F, Fernandez, C, Plana, N, Montserrat, E, Alia, J, Oliva, M, Sanmartin, J, Alvarez, M, Melenchon, J, Vera, T, Soriano, F, Riesco, L, Macian, M, Granado, J, Navarro, M, Sales, J, Perez, J, Caamano, M, Gomez, G, Romo, A, Diaz, M, Alonso, C, Alvarez, D, Amaro, M, Andere, N, Villar, J, Ochoa, R, Austria, A, Barbeira, S, Feu, E, Bartes, A, Munoz, V, Jimenez, F, Tijuan, A, Ramirez, J, Ramos, M, Martinez, E, Moreno, M, Corchado, G, Gil, M, Orive, M, Fernandez, D, del Misterio, M, Alsina, R, Cabrera, A, de Faria, J, Costas, S, Marco, M, Dachs, M, Lopez, C, Borras, A, Madariaga, A, Espallargas, A, Escobar, E, Mas, E, Ferrer, A, Fosch, J, Bermudez, M, Millan, V, Saenz, M, Gomez, C, Perez, Y, Segovia, A, Gonzalez, P, Grigorian, L, Molina, A, del Val, M, Maeso, B, Rodriguez, E, Garcia, A, Besa, B, Salvadores, P, Bouzamayor, M, Lasuncion, I, Gort, L, Molina, M, Lopez, M, Rey, A, Guerra, J, Marcus, S, Vila, A, Mena, M, Mazon, P, Zurita, F, Millan, G, Alia, P, Montes, D, Munoz, R, Palma, A, Figueroa, H, Ortega, V, Cortes, C, Tomera, D, Merchan, N, Ibar, I, Garcia, E, Armayor, M, Carasa, M, Prieto, I, Quintern, V, Renom, R, Diaz, L, Rios, V, Sola, L, Rivera, R, Robiro, X, Roca, M, Saumell, C, Rodrigo, C, Garcia, M, Jimenez, S, Calderon, P, Mendez, L, Parra, S, Santolaya, C, Sanz, M, Blanco, A, Serralvo, E, Sierra, N, Valero, C, Lopez, J, Fontanillas, M, Riera, M, Tobajas, G, Torres, C, Marques, J, Pastor, M, Wirdby, A, Linden, J, Henriksson, K, Elmersson, M, Egilsson, A, Borjesson, U, Svard, G, Liu, B, Lindh, A, Olsson, L, Gustavsson, M, Andersson, L, Benson, L, Bothin, C, Hajimirsadeghi, A, Kadir, K, Ericsson, M, Ohlsson, A, Lindvall, H, Svensson, P, Thorne, K, Handel, H, Platonov, P, Eriksson, B, Timberg, I, Romberg, K, Crisby, M, Karlsson, J, Jensen, S, Andersson, A, Malmqvist, L, Martinsson, B, Bernsten, F, Engdahl, J, Thulin, J, Hot-Bjelac, A, Stalby, P, Aaroe, H, Ahbeck, E, Ahlmark, H, Al-Khalili, F, Bonkowski, G, Dzeletovic, S, Ekstrand, A, Eriksson, G, Floren, K, Grassjo, C, Hahn, S, Jaensson, P, Jansson, B, Jansson, J, Kangert, R, Koch, A, Kusiak, D, Lettenstrom, A, Lindberg, A, Lindholm, C, Mannermyr, A, Mansson, K, Millborg, M, Nilsson, C, Ohlin, A, Olofsson, A, Osberg, A, Pedersen, A, Risbecker, K, Rosenberg, K, Samuelsson, J, Shayesteh, M, Skoglund, K, Stjernberg, M, Thorsen, C, Beer, J, Debrunner, J, Amstutz, D, Bruegger, J, Elise, G, Grau, A, Guinand, A, Henriette, I, Saga, E, Winnik, S, Rudyk, I, Tseluyko, V, Karpenko, O, Zhurba, S, Kraiz, I, Kupnovytska, I, Serediuk, N, Mostovoy, Y, Ushakov, O, Koval, O, Kovalskyi, I, Svyshchenko, Y, Sychov, O, Stanislavchuk, M, Kraydashenko, O, Yagensky, A, Tykhonova, S, Fushtey, I, Belegai, R, Berko, G, Burdeuna, L, Chabanna, O, Daniuk, I, Ivanov, A, Kamenska, E, Kaplan, P, Khyzhnyak, O, Kizim, S, Matova, O, Medentseva, O, Mochonyi, V, Mospan, M, Nemtsova, V, Ovdiienko, T, Palamarchuk, O, Pavelko, M, Petrovskyy, R, Plevak, D, Proshak, O, Pyvovar, S, Rasputina, L, Romanenko, O, Romanova, O, Sapatyi, A, Shumakov, O, Stets, R, Todoriuk, L, Varenov, V, Chauhan, N, Goodwin, D, Saunders, P, Evans, R, Leese, J, Jhittay, P, Ross, A, Kainth, M, Pickavance, G, Mcdonnell, J, Williams, A, Gooding, T, Wagner, H, Suryani, S, Singal, A, Sircar, S, Bilas, R, Hutchinson, P, Wakeman, A, Stokes, M, Paul, N, Aziz, M, Ramesh, C, Wilson, P, Franklin, S, Fairhead, S, Thompson, J, St Joseph, V, Taylor, G, Tragen, D, Seamark, D, Paul, C, Richardson, M, Jefferies, A, Sharp, H, Jones, H, Giles, C, Page, M, Oginni, O, Aldegather, J, Wetherwell, S, Lumb, W, Evans, P, Scouller, F, Macey, N, Stipp, Y, West, R, Thurston, S, Wadeson, P, Matthews, J, Pandya, P, Gallagher, A, Railton, T, Sinha, B, Russell, D, Davies, J, Ainsworth, P, Jones, C, Weeks, P, Eden, J, Kernick, D, Murdoch, W, Lumley, L, Patel, R, Wong, S, Saigol, M, Ladha, K, Douglas, K, Cumberlidge, D, Bradshaw, C, Van Zon, G, Jones, K, Thomas, M, Watson, E, Sarai, B, Ahmad, N, Willcock, W, Cairns, J, Sathananthan, S, de Kare-Silver, N, Gilliland, A, Strieder, E, Howitt, A, Vishwanathan, B, Bird, N, Gray, D, Clark, M, Bisatt, J, Litchfield, J, Fisher, E, Fooks, T, Kelsall, A, Alborough, E, Wakeling, J, Parfitt, M, Milne, K, Rogers, S, Priyadharshan, R, Oliver, J, Davies, E, Abushal, S, Jacobs, M, Hutton, C, Walls, N, Thompson, R, Chigbo, C, Zaidi, S, Howard, M, Butter, K, Barrow, S, Little, H, Haq, I, Gibbons, L, Glencross, S, Mcleod, A, Poland, K, Mulholland, C, Warke, A, Conn, P, Burns, G, Smith, R, Lowe, S, Kamath, R, Dau, H, Webster, J, Hodgins, I, Vercoe, S, Roome, P, Pinnock, H, Patel, J, Ali, A, Hart, N, Davies, R, Stuart, E, Neden, C, Danielsen, M, Heath, R, Sharma, P, Galloway, S, Hawkins, C, Oliver, R, Aylward, M, Mannion, S, Braddick, M, Edwards, D, Rothwell, A, Sabir, A, Choudhary, F, Khalaque, S, Wilson, A, Peters, S, Coulson, W, Roberts, N, Heer, A, Coates, S, Ward, B, Jackson, D, Walton, S, Shepherd, D, Sterry, M, Wong, T, Boon, M, Bunney, R, Haria-Shah, R, Baron, R, Davies, S, Schatzberger, T, Hargreaves, N, Stephenson, T, Batson, R, Lucraft, L, Myhill, T, Estifano, S, Geatch, D, Wilkinson, J, Veale, R, Forshaw, K, Davies, T, Zaman, K, Vinson, P, Liley, C, Bandrapalli, M, Mcginty, P, Wastling, R, Mceleny, P, Beattie, A, Cooke, P, Wong, M, Gunasegaram, J, Pugsley, M, Ahmad, S, A'Court, C, Ayers, J, Bennett, J, Cartwright, S, Dobson, S, Dooldeniya, C, Flynn, A, Fox, R, Goram, J, Halpin, A, Hay, A, Jacobs, P, Jeffers, L, Lomax, L, Munro, I, Muvva, R, Nadaph, M, Powell, K, Randfield, S, Redpath, D, Reed, R, Rickenbach, M, Rogers, G, Seamark, C, Shewring, J, Simmons, P, Simper, H, Stoddart, H, Sword, A, Thomas, N, Thomson, A, Blenkhorn, A, Singh, B, Van Gaal, W, Abhayaratna, W, Lehman, R, Roberts-Thomson, P, Kilian, J, Coulshed, D, Catanchin, A, Colquhoun, D, Kiat, H, Eccleston, D, French, J, Zimmett, L, Ayres, B, Phan, T, Blombery, P, Crimmins, D, O'Donnell, D, Choi, A, Astridge, P, Arstall, M, Jepson, N, Binnekamp, M, Lee, A, Rogers, J, Starmer, G, Carroll, P, Faunt, J, Aggarwala, A, Barry, L, Batta, C, Beveridge, R, Black, A, Bonner, M, Boys, J, Buckley, E, Campo, M, Carlton, L, Connelly, A, Conway, B, Cresp, D, Dimitri, H, Dixon, S, Dolman, M, Duroux, M, Eskandari, M, Eslick, R, Ferreira-Jardim, A, Fetahovic, T, Fitzpatrick, D, Geraghty, R, Gibbs, J, Grabek, T, Modi, M, Hayes, K, Hegde, M, Hesketh, L, Hoffmann, B, Johnson, K, Juergens, C, Kassam, I, Lawlor, V, Lehman, M, Lehman, S, Leung, D, Mackay, S, Mackenzie, M, Mccarthy, C, Mcintosh, C, Mckeon, L, Morrison, H, Mussap, C, Myers, J, Nagalingam, V, Oldfield, G, O'May, V, Palmer, J, Parsons, L, Patching, K, Patching, T, Paul, V, Plotz, M, Preston, S, Rashad, H, Ratcliffe, M, Raynes, S, Rose, J, Sanders, L, Seremetkoska, M, Setio, H, Shone, S, Shrestha, P, Singh, C, Singleton, C, Stoyanov, N, Sutcliffe, S, Swaraj, K, Tarrant, J, Thompson, S, Tsay, I, Vorster, M, Waldman, A, Wallis, L, Wilford, E, Wong, K, Luton, R, Gupta, M, Pandey, A, Cheung, S, Leader, R, Beaudry, P, Ayala-Paredes, F, Berlingieri, J, Heath, J, Poirier, G, Du Preez, M, Nadeau, R, Dresser, G, Dhillon, R, Hruczkowski, T, Schweitzer, B, Coutu, B, Angaran, P, Macdonald, P, Vizel, S, Fikry, S, Parkash, R, Lavoie, A, Cha, J, Ramjattan, B, Bonet, J, Ahmad, K, Aro, L, Aves, T, Beaudry, K, Bergeron, C, Bigcanoe, J, Bignell, N, Breakwell, L, Burke, E, Carroll, L, Clarke, B, Cleveland, T, Daheb, S, Dehghani, P, Denis, I, Djaidani, Z, Dorian, P, Douglass, S, Dunnigan, J, Ewert, A, Farquhar, D, Fearon, A, Ferleyko, L, Fournier, D, Fox, B, Grenier, M, Gulliver, W, Haveman, K, Hines, C, Hines, K, Jackson, A, Jean, C, Jethoo, G, Kahlon, R, Kelly, S, Kim, R, Korley, V, Kornder, J, Kwan, L, Largy, J, Lewis, C, Lewis, S, Mangat, I, Moor, R, Navratil, J, Neas, I, Otis, J, Otis, R, Pandey, M, Petrie, F, Pinter, A, Raines, M, Roberts, P, Robinson, M, Sas, G, Schulman, S, Snell, L, Spearson, S, Stevenson, J, Trahey, T, Wright, D, El-Aziz, A, Seif, S, El Din, M, El Etriby, S, Elbahry, A, El-Etreby, A, Elkhadem, M, Katta, A, Khairy, T, Mowafy, A, Nawar, M, Ohanissian, A, Reda, A, Reda, M, Salem, H, Sami, N, Samir, S, Setiha, M, Sobhy, M, Soliman, A, Taha, N, Tawfik, M, Zaatout, E, Kettles, D, Bayat, J, Siebert, H, Horak, A, Kelfkens, Y, Garda, R, Pillay, T, Guerra, M, van Zyl, L, Theron, H, Murray, A, Louw, R, Greyling, D, Mntla, P, Ueckermann, V, Loghdey, R, Ismail, S, Ahmed, F, Engelbrecht, J, Ramdass, A, Maharajh, S, Oosthuysen, W, Angel, G, Bester, C, Booysen, M, Boshoff, C, Cannon, C, Cassimjee, S, Chami, C, Conway, G, Davids, A, de Meyer, L, Du Plessis, G, Ellis, T, Henley, L, Karsten, M, Loyd, E, Marks, J, Mavhusa, L, Mostert, M, Page, A, Rikhotso, L, Salie, M, Sasto, J, Shaik, F, Skein, A, Smith, L, Tarr, G, Tau, T, van Zyl, F, Yousef, G, Agrawal, A, Nathani, M, Ibrahim, M, Esheiba, E, Singh, R, Naguib, A, Abu-Mahfouz, M, Al Omairi, M, Al Naeemi, A, Maruthanayagam, R, Bazargani, N, Wassef, A, Gupta, R, Khan, M, Subbaraman, B, Abdul, A, Al Mulla, A, El Bardisy, S, Haridas, P, Jadhav, S, Magdaluyo, K, Makdad, M, Maqsood, I, Mohamed, R, Sharma, N, Sharma, R, Thanzeel, M, Canosa, R, Rama, P, Blumberg, E, Garcia, J, Mullen, P, Wilson, V, Quick, A, Ferrick, K, Kutayli, W, Cox, M, Franco, M, Falkowski, S, Mendelson, R, Williams, M, Miller, S, Beach, S, Alfieri, A, Gutowski, T, Haque, I, Reddy, R, Ahmed, W, Delafontaine, P, Diercks, D, Theodoro, D, Remmel, K, Alberts, M, Ison, R, Noveck, H, Duffy, P, Pitta, S, Nishijima, D, Treasure, C, Asafu-Adjaye, N, Ball, K, Bartlett, M, Bentley, M, Bowers, S, Brown, A, Browne, A, Cameron-Watts, J, Canova, M, Cassidy, D, Cervellione, K, Congal, S, Depauw, J, Dickerson, A, Eley, M, Evans, L, Felpel, S, Ferdinand, K, Fielder, D, Gentry, P, Haideri, A, Hakimi, F, Harbour, T, Hartranft, E, Hawkins, B, Headlee, M, Henson, L, Herrick, C, Hicks, T, Jasinski, S, Jones, A, Jones, L, Jones, P, Karl, S, Keeling, M, Kerr, J, Knowles, P, Langdon, J, Lay, M, Lee, J, Lincoln, T, Malone, E, Merliss, A, Merritt, D, Minardo, J, Mooso, B, Orosco, C, Palumbo, V, Parker, M, Parrott, T, Paserchia, S, Pearl, G, Peterson, J, Pickelsimer, N, Purcell, T, Raynor, J, Raziano, S, Richard, C, Richardson, T, Robertson, C, Sage, A, Sanghera, T, Shaw, P, Shoemaker, J, Smith, K, Stephanie, B, Thatcher, A, Theobald, H, Thompson, N, Treasure, L, Tripti, T, Verdi, C, Worthy, V, Jerjes-Sanchez, C., Corbalan, R., Barretto, A. C. P., Luciardi, H. L., Allu, J., Illingworth, L., Pieper, K. S., Kayani, G., Fitzmaurice, D. A., Goto, S., Hacke, W., Mantovani, L. G., Turpie, A. G. G., Gersh, B. J., Gibbs, H., Brodmann, M., Cools, F., Connolly, S. J., Spyropoulos, A., Eikelboom, J., Hu, D., Jansky, P., Nielsen, J. D., Ragy, H., Raatikainen, P., Le Heuzey, J. -Y., Darius, H., Keltai, M., Kakkar, S., Sawhney, J. P. S., Agnelli, G., Ambrosio, G., Koretsune, Y., Diaz, C. J. S., ten Cate, H., Atar, D., Stepinska, J., Panchenko, E., Lim, T. W., Jacobson, B., Oh, S., Vinolas, X., Rosenqvist, M., Steffel, J., Angchaisuksiri, P., Parkhomenko, A., Al Mahmeed, W., Chen, K. N., Zhao, Y. S., Zhang, H. Q., Chen, J. Z., Cao, S. P., Wang, D. W., Yang, Y. J., Li, W. H., Yin, Y. H., Tao, G. Z., Yang, P., Chen, Y. M., He, S. H., Wang, Y., Fu, G. S., Li, X., Wu, T. G., Cheng, X. S., Yan, X. W., Zhao, R. P., Chen, M. S., Xiong, L. G., Chen, P., Jiao, Y., Guo, Y., Xue, L., Wang, F. Z., Li, H., Yang, Z. M., Bai, C. L., Chen, J., Chen, J. Y., Chen, X., Feng, S., Fu, Q. H., Gao, X. J., Guo, W. N., He, R. H., He, X. A., Hu, X. S., Huang, X. F., Li, B., Li, J., Li, L., Li, Y. H., Liu, T. T., Liu, W. L., Liu, Y. Y., Lu, Z. C., Luo, X. L., Ma, T. Y., Peng, J. Q., Sheng, X., Shi, X. J., Sun, Y. H., Tian, G., Wang, K., Wang, L., Wu, R. N., Xie, Q., Xu, R. Y., Yang, J. S., Yang, L. L., Yang, Q., Ye, Y., Yu, H. Y., Yu, J. H., Yu, T., Zhai, H., Zhan, Q., Zhang, G. S., Zhang, Q., Zhang, R., Zhang, Y., Zheng, W. Y., Zhou, B., Zhou, Z. H., Zhu, X. Y., Jadhav, P., Durgaprasad, R., Ravi Shankar, A. G., Rajput, R. K., Bhargava, K., Sarma, R., Srinivas, A., Roy, D., Nagamalesh, U. M., Chopda, M., Kishore, R., Kulkarni, G., Chandwani, P., Pothiwala, R. A., Padinhare Purayil, M., Shah, S., Chawla, K., Kothiwale, V. A., Raghuraman, B., Vijayaraghavan, G., Vijan, V. M., Bantwal, G., Bisne, V., Khan, A., Gupta, J. B., Kumar, S., Jain, D., Abraham, S., Adak, D., Barai, A., Begum, H., Bhattacharjee, P., Dargude, M., Davies, D., Deshpande, B., Dhakrao, P., Dhyani, V., Duhan, S., Earath, M., Ganatra, A., Giradkar, S., Jain, V., Karthikeyan, R., Kasala, L., Kaur, S., Krishnappa, S., Lawande, A., Lokesh, B., Madarkar, N., Meena, R., More, P., Naik, D., Prashanth, K., Rao, M., Rao, N. M., Sadhu, N., Shah, D., Sharma, M., Shiva, P., Singhal, S., Suresh, S., Vanajakshamma, V., Panse, S. G., Kanamori, S., Yamamoto, K., Kumagai, K., Katsuda, Y., Sadamatsu, K., Toyota, F., Mizuno, Y., Misumi, I., Noguchi, H., Ando, S., Suetsugu, T., Minamoto, M., Oda, H., Shiraishi, K., Adachi, S., Chiba, K., Norita, H., Tsuruta, M., Koyanagi, T., Ando, H., Higashi, T., Okada, K., Azakami, S., Komaki, S., Kumeda, K., Murayama, T., Matsumura, J., Oba, Y., Sonoda, R., Goto, K., Minoda, K., Haraguchi, Y., Suefuji, H., Miyagi, H., Kato, H., Nakamura, T., Nandate, H., Zaitsu, R., Fujiura, Y., Yoshimura, A., Numata, H., Ogawa, J., Tatematsu, H., Kamogawa, Y., Murakami, K., Wakasa, Y., Yamasawa, M., Maekawa, H., Abe, S., Kihara, H., Tsunoda, S., Saito, K., Fudo, T., Obunai, K., Tachibana, H., Oba, I., Kuwahata, T., Higa, S., Gushiken, M., Eto, T., Yoshida, H., Ikeda, D., Ishizawa, M., Nakatsuka, M., Murata, K., Ogurusu, C., Shimoyama, M., Akutsu, M., Takamura, I., Hoshino, F., Yokota, N., Iwao, T., Tsuchida, K., Takeuchi, M., Hatori, Y., Kitami, Y., Nakamura, Y., Oyama, R., Ageta, M., Go, Y., Mishima, K., Unoki, T., Morii, S., Shiga, Y., Sumi, H., Nagatomo, T., Sanno, K., Fujisawa, K., Atsuchi, Y., Nagoshi, T., Seto, T., Tabuchi, T., Kameko, M., Nii, K., Oshiro, K., Takezawa, H., Nagano, S., Miyamoto, N., Iwaki, M., Fujii, M., Okawa, M., Abe, M., Saito, T., Mito, T., Nagao, K., Minami, J., Mita, T., Sakuma, I., Taguchi, T., Marusaki, S., Doi, H., Tanaka, M., Fujito, T., Matsuta, M., Kusumoto, T., Kakinoki, S., Ashida, K., Yoshizawa, N., Agata, J., Arasaki, O., Manita, M., Ikemura, M., Fukuoka, S., Murakami, H., Matsukawa, S., Hata, Y., Taniguchi, T., Ko, T., Kubo, H., Imamaki, M., Akiyama, M., Inagaki, M., Odakura, H., Ueda, T., Katsube, Y., Nakata, A., Watanabe, H., Techigawara, M., Igarashi, M., Taga, K., Kimura, T., Tomimoto, S., Shibuya, M., Nakano, M., Ito, K., Seo, T., Hiramitsu, S., Hosokawa, H., Hoshiai, M., Hibino, M., Miyagawa, K., Horie, H., Sugishita, N., Soma, A., Neya, K., Yoshida, T., Mizuguchi, M., Ishiguro, M., Minagawa, T., Wada, M., Mukawa, H., Okuda, F., Nagasaka, S., Abe, Y., Adachi, T., Akahane, K., Amano, T., Aoki, K., Aoyama, T., Arai, H., Arima, S., Arino, T., Asano, H., Asano, T., Azuma, J., Baba, T., Betsuyaku, T., Chibana, H., Date, H., Doiuchi, J., Emura, Y., Endo, M., Fujii, Y., Fujiki, R., Fujisawa, A., Fujisawa, Y., Fukuda, T., Fukui, T., Furukawa, N., Furukawa, T., Furumoto, W., Goto, T., Hamaoka, M., Hanazono, N., Hasegawa, K., Hatsuno, T., Hayashi, Y., Higuchi, K., Hirasawa, K., Hirayama, H., Hirose, M., Hirota, S., Honda, M., Ido, T., Iiji, O., Ikeda, H., Ikeda, K., Ikeoka, K., Imaizumi, M., Inaba, H., Inoue, T., Iseki, F., Ishihara, A., Ishioka, N., Ito, N., Iwase, T., Kakuda, H., Kamata, J., Kanai, H., Kanda, H., Kaneko, M., Kano, H., Kasai, T., Kato, T., Kato, Y., Kawada, Y., Kawai, K., Kawakami, K., Kawakami, S., Kawamoto, T., Kawano, S., Kim, J., Kira, T., Kitazawa, H., Kitazumi, H., Kito, T., Kobayashi, T., Koeda, T., Kojima, J., Komatsu, H., Komatsu, I., Koshibu, Y., Kotani, T., Kozuka, T., Kumai, Y., Kumazaki, T., Maeda, I., Maeda, K., Maruyama, Y., Matsui, S., Matsushita, K., Matsuura, Y., Mineoi, K., Mitsuhashi, H., Miura, N., Miyaguchi, S., Miyajima, S., Miyamoto, H., Miyashita, A., Miyata, S., Mizuguchi, I., Mizuno, A., Mori, T., Moriai, O., Morishita, K., Murai, O., Nagai, S., Nagata, E., Nagata, H., Nakagomi, A., Nakahara, S., Nakamura, M., Nakamura, R., Nakanishi, N., Nakayama, T., Nakazato, R., Nanke, T., Nariyama, J., Niijima, Y., Niinuma, H., Nishida, Y., Nishihata, Y., Nishino, K., Nishioka, H., Nishizawa, K., Niwa, I., Nomura, K., Nomura, S., Nozoe, M., Ogawa, T., Ohara, N., Okada, M., Okamoto, K., Okita, H., Okuyama, M., Ono, H., Ono, T., Pearce, Y. O., Oriso, S., Ota, A., Otaki, E., Saito, Y., Sakai, H., Sakamoto, N., Sakamoto, Y., Samejima, Y., Sasagawa, Y., Sasaguri, H., Sasaki, A., Sasaki, T., Sato, K., Sawano, M., Seki, S., Sekine, Y., Seta, Y., Sezaki, K., Shibata, N., Shiina, Y., Shimono, H., Shimoyama, Y., Shindo, T., Shinohara, H., Shinohe, R., Shinozuka, T., Shirai, T., Shiraiwa, T., Shozawa, Y., Suga, T., Sugimoto, C., Suzuki, K., Suzuki, S., Suzuki, Y., Tada, M., Taguchi, A., Takagi, T., Takagi, Y., Takahashi, K., Takahashi, S., Takai, H., Takanaka, C., Take, S., Takeda, H., Takei, K., Takenaka, K., Tana, T., Tanabe, G., Taya, K., Teragawa, H., Tohyo, S., Toru, S., Tsuchiya, Y., Tsuji, T., Tsuzaki, K., Uchiyama, H., Ueda, O., Ueyama, Y., Wakaki, N., Wakiyama, T., Washizuka, T., Watanabe, M., Yamada, T., Yamagishi, T., Yamaguchi, H., Yamamoto, T., Yamaura, M., Yamazoe, M., Yasui, K., Yokoyama, Y., Yoshida, K., Ching, C. K., Foo, C. G., Chow, J. H., Chen, D. D., Jaufeerally, F. R., Lee, Y. M., Lim, G., Lim, W. T., Thng, S., Yap, S. Y., Yeo, C., Pak, H. N., Kim, J. -B., Kim, J. H., Jang, S. -W., Kim, D. H., Ryu, D. R., Park, S. W., Kim, D. -K., Choi, D. J., Oh, Y. S., Cho, M. -C., Kim, S. -H., Jeon, H. -K., Shin, D. -G., Park, J. S., Park, H. K., Han, S. -J., Sung, J. H., Cho, J. -G., Nam, G. -B., On, Y. K., Lim, H. E., Kwak, J. J., Cha, T. -J., Hong, T. J., Park, S. H., Yoon, J. H., Kim, N. -H., Kim, K. -S., Jung, B. C., Hwang, G. -S., Kim, C. -J., Kim, D. B., Ahn, J. J., An, H. J., Bae, H., Baek, A. L., Chi, W. J., Choi, E. A., Choi, E. H., Choi, H. K., Choi, H. S., Han, S., Heo, E. S., Her, K. O., Hwang, S. W., Jang, E. M., Jang, H. -S., Jang, S., Jeon, H. -G., Jeon, S. R., Jeon, Y. R., Jeong, H. K., Jung, I. -A., Kim, H. J., Kim, J. S., Kim, J. A., Kim, K. T., Kim, M. S., Kim, S. H., Kim, Y. -I., Lee, C. S., Lee, E. H., Lee, G. H., Lee, H. Y., Lee, H. -Y., Lee, K. H., Lee, K. R., Lee, M. S., Lee, M. -Y., Lee, R. W., Lee, S. E., Lee, S. H., Lee, S., Lee, W. Y., Noh, I. K., Park, A. R., Park, B. R., Park, H. N., Park, J. H., Park, M., Park, Y., Seo, S. -Y., Shim, J., Sim, J. H., Sohn, Y. M., Son, W. S., Son, Y. S., Song, H. J., Wi, H. K., Woo, J. J., Ye, S., Yim, K. H., Yoo, K. M., Yoon, E. J., Yun, S. Y., Chawanadelert, S., Mongkolwongroj, P., Kanokphatcharakun, K., Cheewatanakornkul, S., Laksomya, T., Pattanaprichakul, S., Chantrarat, T., Rungaramsin, S., Silaruks, S., Wongcharoen, W., Siriwattana, K., Likittanasombat, K., Katekangplu, P., Boonyapisit, W., Cholsaringkarl, D., Chatlaong, B., Chattranukulchai, P., Santanakorn, Y., Hutayanon, P., Khunrong, P., Bunyapipat, T., Jai-Aue, S., Kaewsuwanna, P., Bamungpong, P., Gunaparn, S., Hongsuppinyo, S., Inphontan, R., Khattaroek, R., Khunkong, K., Kitmapawanont, U., Kongsin, C., Naratreekoon, B., Ninwaranon, S., Phangyota, J., Phrommintikul, A., Phunpinyosak, P., Pongmorakot, K., Poomiphol, S., Pornnimitthum, N., Pumprueg, S., Ratchasikaew, S., Sanit, K., Sawanyawisuth, K., Silaruks, B., Sirichai, R., Sriwichian, A., Suebjaksing, W., Sukklad, P., Suttana, T., Tangsirira, A., Thangpet, O., Tiyanon, W., Vorasettakarnkij, Y., Wisaratapong, T., Wongtheptien, W., Wutthimanop, A., Yawila, S., Altun, A., Ozdogru, I., Ozdemir, K., Yilmaz, O., Aydinlar, A., Yilmaz, M. B., Yeter, E., Ongen, Z., Cayli, M., Pekdemir, H., Ozdemir, M., Sucu, M., Sayin, T., Demir, M., Yorgun, H., Ersanli, M., Okuyan, E., Aras, D., Abdelrahman, H., Aktas, O., Alpay, D., Aras, F., Bireciklioglu, M. F., Budeyri, S., Buyukpapuc, M., Caliskan, S., Esen, M., Felekoglu, M. A., Genc, D., Ikitimur, B., Karaayvaz, E. B., Karatas, S. K., Okutucu, S., Ozcelik, E., Quisi, A., Sag, H., Sahiner, L., Sayin, B. Y., Seker, T., Alkan, D. U., Yildirim, E., Yildirim, R., Yilmaz, F., Yuksekdag, V., Vensentini, N., Ingaramo, A. C., Sambadaro, G. A., Caputi, V. F., Berman, S. G., Dragotto, P., Kleiban, A. J., Centurion, N., Giacomi, G., Guerrero, R. A. A., Conde, D., Zapata, G., Di Paola, L. A., Ramos, J. L., Dran, R. D., Egido, J., Fernandez, A. A., Fosco, M. J., Sassone, S., Sinisi, V. A., Cartasegna, L. R., Berli, M. A., Vilamajo, O. A. G., Ferroni, F., Alaguibe, E. D., D'Amelio, A. A., Arabetti, C., Arias, L., Belardi, J. A., Bergesio, L., Berli, F., Berli, M., Borchowiec, S., Buzzetti, C., Cabrini, R., Campisi, V., Cappi, A. L., Carrizo, R., Berra, F. C., Costabel, J. P., Costamagna, O. J. A., Damonte, A. A., De Urquiza, I. N., Diez, F., Eden, M. F., Fanuele, M., Voena, F. F., Torres, M. F., Funosas, C., Giacomi, M. P., Gimenez, C. H., Gurfinkel, E. P., Had, M. D. L. M., Hansen, V., Hrabar, A. D., Ingratta, M., Lopez, A., Maehara, G., Maffei, L., Martinelli, A., Martinelli, C., Matkovich, J., Mautner, B., Meirino, A., Munguia, R., Navarro, A., Novas, V., Prados, G. P., Pontoriero, J., Potito, R. N., Ricotti, C., Rodriguez, M. A., Rolandi, F., Palladino, M. E. S., Salinger, M., Sanziani, L. S., Schygiel, P. O., Sossich, A., Tinto, J. F., Tonelli, L., Tufare, A. L., Vallejo, M., Yunis, M. E., Zillo, M., Zurbrigk, F. J., Filho, D. C. S., Jaber, J., Armaganijan, D., Neto, J. F., Steffens, A., de Souza, W. K. S. B., de Souza Neto, J. D., Ribeiro, J. M., Teixeira, M. S., Rossi, P. R. F., Pires, L., Moreira, D., Jorge, J. C. M., Filho, A. M. L., Bodanese, L. C., Montera, M. W., Del Carlo, C. H., Rodrigues, T. D. R., da Costa, F. A. A., Lopes, A., Lopes, R., Araujo, G. R., Manenti, E. R. F., Saraiva, J. F. K., Braga, J. C. F., Negri, A., Souto, L., Moncada, C., Precoma, D. B., Roquette, F., Reis, G., Filho, R. A. R., Figueiredo, E. L., Botelho, R. V., Tavares, C. M. D. F., Frack, C. R. C., Saad, J. A., Finimundi, H. C., Pisani, C., Chemello, D., Martins, M. P., Franca, C. C. B., Alban, F., Rosito, G. B. A., Moraes Junior, J. B. M. X., Tumelero, R. T., Maia, L. N., de Almeida, R. S., do Carmo Borges, N. C., Ferreira, L. G. G., Agliardi, P., Gomes, J. A. O., Araujo, V., Nakazone, M. A., Barbosa, T., Barroso, S., Falchetto, E. B., Lopes, H. B., Lemos, M. A. B. T., Biazus, G., Queiroz, L. B., Camazzola, F. E., Caporale, M., Cardoso Boscato, S., Chieza, F., Chokr, M. O., Mingireanov, R. C., Goes, N. C., Correa, C., Costa, M., Ortiz, C. C., da Silva, L. S., Paulitsch, F. D. S., da Silveira, J. A., Daros, E., de Araujo, G. R., Del Monaco, M. I., Dias, C., Dias, M. A., Wainstein, A. P. D., Pizzato, P. E., Esteves, D. C., Fabri, P., Fonseca, T. F. L., Fernandes, E., Fonseca, C., Costantini, C. R. F., Ferraz, R. F., Freire, F., Gottardo, P., Guanaes, D., Guizzardi, S., Magedanz, E. H., Igansi, F., Jannuzzi, F., Junior, G., Komar, D., Lino, E. G., Lopes, D., Junior, O. L. D. S., Lustosa, E., Macagnan, A. P., Marinho, M. C., Mazzoni, M., Melo, G., Mortari, L., Mouco, O. M. C. C., Vital, C. N., Ormundo, C., Emmer, S. O., Palmegiani, E., Pavani, R., Pereira, L., Pereira, V. L., Perreira, R., Poletti, S., Fortunato, S. C. Q., Queirantes, C., Pereira, N. R., Rech, R. L., Ribeiro, S., Rodrigues, A., Roesch, H., Reichert, T. R., Santos, D., Santos, I., Santos, M., Seroqui, M. V., Silva, S., Soares, L., Spolaor, L., Stoll, C., Duda, N. T., Trama, L., Unterkircher, B., Valois, M. V., Vargas, T., Viana, T., Vicente, C., Armaganijan, L. V., Homem, R. V., Torres, L. G. V., Vila, L., Filho, F. V. G., Eggers, G., Gutierrez, C. B., Arriagada, G., Cardenas, S. P., Fernandez, B. A. J. S., Conejeros, C., Houzvic, C., Cuevas, P. M., Montecinos, H., Forero, A., Lanas, F., Gomez, M. L., Vilches, G. C., Rey, C., Astudillo, C., Aguilar, J., Campisto, Y., Lara, C., Molina, E., Oyarzon, J. M., Olguin, V., Vergara, M., Villan, C., Diaz, J. I., Cantu, R. L., Zavala, M. G. R., Jardines, R. C., Zavaleta, N. E., Umana, S. V., Rosas, E. L., Esperon, G. L., Pozas, G., Munoz, E. C., Hernandez, N. M., Rendon, A. L., Hernandez, N. G., Ibarra, M. L. R., Carrillo, L. V., Villezca, D. L., Herrera, C. H., Prieto, J. J. L., Rodriguez, R. G., Espinosa, E. V., Martinez, D. F., Barcena, J. V., Yong, R., Briones, I. R., Pons, J. L. L., Lopez, H. A., Ruiz, R. O., de la Vega, C. D., Brito, C. C., Valenzuela, E. C., Reyes-Sanchez, R., Ruiz, A. B., Flores, O. N., Gonzalez, M. B., Nava, R. A., Cerda, J. D. M., Fierro, O. F., Campos, P. F., Alfaro, T. A. A., Bellorin, S. A., Avena, R., Chavarria, M., Espinosa, I., Silva, F. F., Nava, R. H. G., Godoy, K., Felix, E. J. G., Garcia, C. L. G., Salas, L. G. G., Guajardo, P., Gonzalez, S. H., Izquierdo, T., Ortiz, M. C. M., Vasquez, D. M., Mendoza, N., Morales, J., Nikitina, N., Aybar, S. O., Ortiz, A., Macias, P. P., Perez, F., Sanchez, J. A. P., Toledano, S. P., Gonzalez, M. R., Ramos, C. R., Castro, V. R., Cardona, G. R., Cornejo, M. R., Salinas, A., Santana, G., Perez, P. S., Castaneda, A. C. T., Cortes, R. T., Lenz, K., Drexel, H., Foechterle, J., Hagn, C., Podczeck-Schweighofer, A., Huber, K., Winkler, M., Schneeweiss, B., Gegenhuber, A., Lang, W., Eichinger-Hasenauer, S., Kaserer, P., Sykora, J., Rasch, H., Pichler, M., Schaflinger, E., Strohmer, B., Breier, R., Ebner, K. -M., Eischer, L., Freihoff, F., Lischka-Lindner, A., Mark, T., Mirtl, A., Said, A., Stocklocker, C., Vogel, B., Vonbank, A., Wohrer, C., Zanolin, D., Paparella, G., Vandergoten, P., Parque, J. -L., Capiau, L., Vervoort, G., Wollaert, B., Desfontaines, P., Mairesse, G., Boussy, T., Godart, P., De Wolf, A., Voet, J., Heyse, A., Hollanders, G., Anne, W., Vercammen, J., Purnode, P., Blankoff, I., Faes, D., Balthazar, Y., Beutels, M., Marechal, P., Verstraete, S., Xhaet, O., Striekwold, H., Thoeng, J., Hermans, K., Alzand, B., Ascoop, A. -K., Banaeian, F., Barbuto, A. -M., Billiaux, A. C., Blockmans, M., Bouvy, C., Brike, C., Capiau, H., Casier, T., Bolado, A. C. Y., De Cleen, D., De Coninck, M., de Vos, M., de Weerdt, N., Delforge, M., Delvigne, M., Denie, D., Derycker, K., Deweerd, E., Dormal, F., Drieghe, S., Everaert, M., Eykerman, T., Feys, E., Ghekiere, M., Gits, F., Hellemans, S., Helvasto, L., Jacobs, C., Lips, S., Mestdagh, I., Nimmegeers, J., Piamonte, V., Pollet, P., Postolache, A., Raepers, M., Raymenants, E., Richa, J., Rombouts, H., Salembier, J., Scheurwegs, C., Semeraro, O., Simons, N., Smessaert, C., Smolders, W., Stockman, I., Tahon, S., Thyssen, V., Tincani, G., Van Durme, F., Van Lier, D., Vandekerckhove, H., Vandekerckhove, Y., Vandenbroeck, D., Vandorpe, A., Vanhalst, E., Vanhauwaert, B., Vantomme, C., Vergauwen, L., Verloove, H., Vydt, T., Weyn, T., Reichert, P., Spacek, R., Machova, V., Zidkova, E., Ludka, O., Olsr, J., Kotik, L., Plocova, K., Racz, B., Ferkl, R., Hubac, J., Kotik, I., Monhart, Z., Burianova, H., Jerabek, O., Pisova, J., Petrova, I., Dedek, V., Honkova, M., Podrazil, P., Spinar, J., Vitovec, J., Novak, M., Lastuvka, J., Durdil, V., Antonova, P., Bockova, L., Bultas, J., Chlumsky, J., Dastychova, L., Drasnar, T., Honek, J., Horejsi, M., Hubacova, V., Janska, L., Kopeckova, I., Kratochvilova, R., Krcova, E., Labrova, R., Lindourkova, A., Lipoldova, J., Lubanda, H., Ludkova, A., Mahdalikova, L., Majernikova, M., Michalik, D., Potuznik, P., Prochazkova, E., Sulc, A., Sveceny, J., Valtova, M., Zidek, M., Zika, J., Nielsen, H., Husted, S., Hintze, U., Rasmussen, S., Bremmelgaard, A., Markenvard, J., Boerger, J., Solgaard, J., Simonsen, P., Loekkegaard, T., Bruun, M., Mertz, J., Dominguez, H., Skagen, K., Egstrup, K., Ibsen, H., Raymond, I., Bang-Hansen, T., Ellervik, C., Eriksen, E., Jensen, L., Jensen, M., Leth, M., Nygaard, A., Park, J., Schou, M., Therkelsen, A., Tilma, J., Vesterager, K., Airaksinen, J., Arola, O., Koistinen, J., Nappila, H., Peltomaki, K., Rasanen, V., Vasankari, T., Galinier, M., Gottwalles, Y., Paganelli, F., Loiselet, P., Muller, J. -J., Koujan, M. B., Marquand, A., Destrac, S., Piot, O., Delarche, N., Cebron, J. -P., Boveda, S., Guenoun, M., Guedj-Meynier, D., Galley, D., Ohayon, J., Assouline, S., Zuber, M., Amarenco, P., Ellie, E., Kadouch, J., Fournier, P. -Y., Huberman, J. -P., Lemaire, M., Rodier, G., Milandre, L., Vandamme, X., Sibon, I., Neau, J. -P., Mahagne, M. H., Mielot, A., Bonnefoy, M., Churet, J. -B., Navarre, V., Sellem, F., Monniot, G., Boyes, J. -P., Doucet, B., Martelet, M., Obadia, D., Crousillat, B., Mouallem, J., Bearez, E., Nazeyrollas, P., Brugnaux, J. P., Fedorowsky, A., Casassus, F., Berneau, J. -B., Chemin, F., Falvo, N., Perron, J. -M., Poulard, J. -E., Barreau, A., Beltra, C., Corrihons, E., Decarsin, N., Dubois, B., Ducasse, E., Giry, X., Kemmel, A., Ledure, S., Lemaire, N., Robin, F., Rosolin, N., Sanchez, D., Suissa, A., Koniger, G., Purr, J., Gerbaulet, U., Kellner, B. -T., Kopf, A., Schafer, T., Zauzig, H., Riegel, P., Hohensee, H., Eissfeller, E., Eder, W., Rehling, G., Glatzel, D., Zutz, S., Heinz, G. -U., Menke, H., Pustelnik, A., Sandow, P., Ludwig, N., Wiswedel, H., Wildenauer, W., Axthelm, C., Schwarz, T., Babyesiza, A., Stuchlik, G., Zimny, H. -H., Kropp, M., Kahl, F., Caspar, A., Omankowsky, S., Lassig, T., Hartmann, H. -J., Lehmann, G., Bindig, H. -W., Hergdt, G., Reimer, D., Hauk, J., Dorsch, W., Dshabrailov, J., Michel, H., Rapp, K. -A., Vormann, R., Mayer, P., Horstmeier, U., Eissing, V., Hey, H., Leuchtgens, H., Lilienweiss, V., Kolitsch, K., Schubert, C., Lauer, H., Buchner, T., Brauer, G., Kamin, S., Muller, K., Abdel-Qader, M., Baumbach, S., Ebert, H. -H., Schwencke, C., Schellong, S., Bernhardt, P., Karolyi, L., Sievers, B., Haverkamp, W., Salbach, P., Rohnisch, J. -U., Schoen, S., Erdle, W., Mueller, T., Mueller, H., Mitrovic, V., Babjakova, Z., Bergner, K., Boehme, S., Bonin, K., Buckert, D., Busch, F., Dichristin, U., Diez, S., Fleck, A., Flint, K., Floegel, H., Fritz, C., Frommhold, R., Gehre, J., Geyer, J., Grytzmann, A., Hahn, M., Helgert, K., Hubert, K., Kirchner-Volker, K., Klein, V., Kroll, D., Krueger, A., Lehmann, R., Mann, L., Maselli, A., Menken, G., Mikes, K., Mortan, H., Nasser, N., Nicolaus, D., Plauskat, A., Pomper, L., Quietzsch, A., Ravenhorst, C., Reichelt, C., Reimer, C., Schaefer, B., Scharrer, S., Schirmer, K., Schmidt, K., Schoene, R., Schulze, J., Schuppe, M., Simon, S., Sommer, S., Spranger, K., Talkenberger, A., Tauber, K., Tetlak, A., Toennishoff, T., Voelkel-Babyesiza, R., Voigts, B., Weiser, U., Wesendorf, S., Wildenauer, S., Wolf, T., Wurziger, J., Zak, J., Zauzig, H. -D., Ziefle, S., Zincke, S., Vangel, S., Szalai, G., Merkely, B., Kancz, S., Boda, Z., Nagy, A., Laszlo, Z., Matoltsy, A., Gaszner, B., Polgar, P., Habon, T., Noori, E., Juhasz, G., Kanakaridisz, N., Szentpeteri, I., Juhasz, F., Vertes, A., Papp, A., May, Z., Ferenczi, J., Egyutt, M., Kis, E., Engelthaler, G., Szantai, G., Fulop, E., Gombos, P., Gulyas, D., Jen, P., Kiralyhazine Gyorke, E., Kovacs, M., Kovacsne Levang, S., Marianna, S., Radics, Z., Sydo, N., Szalo, R., Szilagyi, A., Sztanyik, F., Vandrus, B., Tiraferri, E., Santoro, R., Testa, S., Di Minno, G., Moia, M., Caimi, T. M., Martini, G., Tessitori, M., Cappelli, R., Poli, D., Quintavalla, R., Melone, F., Cosmi, F., Pizzini, A., Piseddu, G., Fanelli, R., Latella, C., Santi, R., Pancaldi, L., De Cristofaro, R., Palareti, G., De Blasio, A., Salerno Uriarte, J., Minetti, F., Pogliani, E. M., Lonati, L. M., Accogli, M., Ciampani, N., Malengo, S., Feola, M., Raisaro, A., Fattore, L., Grilli, P., Germini, F., Settimi, M., Alunni, M., Duranti, G., Tedeschi, L., Baglioni, G., Avanzino, G., Berardi, M., Pannacci, V., Giombolini, A., Nicoli, S., Scarponi, T., Allasia, B., Ricciarini, P., Nasorri, R., Argena, A., Bossolasco, P., Ronchini, P., Filippi, A., Tradati, F., Bulla, C., Donzelli, L., Foppa, L., Bottarelli, M. L., Tomasello, A., Mauric, A., Femiano, C., Reggio, R., Lillo, F., Mariani, A., Forcignano, F., Volpe, M., D'Avino, M., Bongiorni, M. G., Severi, S., Capucci, A., Lodigiani, C., Salomone, E., Serviddio, G., Tondo, C., Golino, P., Mazzone, C., Iacopino, S., Pengo, V., Galvani, M., Moretti, L., Ambrosino, P., Banfi, E., Biagioli, V., Bianchi, A., Boggian, G., Breschi, M., Brusorio, S., Calcagnoli, F., Campagna, G., Carpenedo, M., Ciabatta, C., Ciliberti, G., Cimmino, G., D'Arienzo, C., Di Gennaro, L., Fedele, M., Ferrini, P. M., Granzow, K., Guazzaloca, G., Guerra, F., Lo Buglio, A., Longo, S., Macellari, F., Mesolella, E., Mollica Poeta, E., Occhilupo, P., Oriana, V., Rangel, G., Salomone, L., Scaccianoce, A., Scarone, C., Segreti, L., Sottilota, G., Villani, R., Zecca, C., Ruiter, J. H., Klomps, H., Bongaerts, M., Pieterse, M. G. C., Guldener, C., Herrman, J. -P., Lochorn, G., Lucassen, A., Adriaansen, H., The, S. H. K., Nierop, P. R., Hoogslag, P. A. M., Hermans, W., Groenemeijer, B. E., Terpstra, W., Buiks, C., Boersma, L. V. A., Boersma-Slootweg, M., Bosman, F., Bosschaert, M., Bruin, S., Danse, I., De Graaf, J., de Graauw, J., Debordes, M., Dols, S., Geerlings, F., Gorrebeeck, K., Jerzewski, A., Jetten, W., Kelderman, M., Kloosterman, T., Koomen, E. M., Krikken, J., Melman, P., Mulder, R., Pronk, A., Stallinga-de Vos, A., te Kaat, J., Tonino, P., Uppelschoten, B., van de Loo, R., van der Kley, T., van Leeuwen, G., van Putten, J. J., Westerman, L., Berge, E., Sirnes, P. A., Gjertsen, E., Hole, T., Erga, K., Hallaraker, A., Skjelvan, G., Ostrem, A., Ghezai, B., Svilaas, A., Christersson, P., Oien, T., Hoegh Henrichsen, S., Berg-Johansen, J., Otterstad, J. E., Antonsen, H., Ausen, K., Claussen, H., Dominguez, I., Jekthammer, A., Lensebraaten, A. B., Nilsen, V., O'Donovan, M., Ringdalen, K., Strand, S., Korzeniak, R., Gieroba, A., Biedrzycka, M., Ogorek, M., Wozakowska-Kaplon, B., Loboz-Grudzien, K., Kosior, J., Supinski, W., Kuzniar, J., Zaluska, R., Hiczkiewicz, J., Swiatkowska-Byczynska, L., Kucharski, L., Gruchala, M., Minc, P., Olszewski, M., Kania, G., Krzciuk, M., Lajkowski, Z., Ostrowska-Pomian, B., Lewczuk, J., Zinka, E., Karczmarczyk, A., Chmielnicka-Pruszczynska, M., Trusz-Gluza, M., Opolski, G., Bronisz, M., Glanowska, G., Ruszkowski, P., Jaworska, K., Sciborski, R., Okopien, B., Kukla, P., Wozniak-Skowerska, I., Galbas, K., Cymerman, K., Jurowiecki, J., Miekus, P., Myszka, W., Mazur, S., Lysek, R., Baszak, J., Rusicka-Piekarz, T., Raczak, G., Domanska, E., Nessler, J., Lesnik, J., Ambicka, M., Andrzejewski, D., Araminowicz, J., Barszcz, A., Bartkowiak, R., Bartnik, J., Basiak, M., Bekieszczuk, E., Bernat, L., Biedrzycki, L., Biernacka, A., Blaszczyk, D., Broton, E., Brzozowski, W., Brzustowska, M., Bzymek, R., Chmielowski, A., Chojnowski, P., Cichomski, R., Cieslak, K., Cieszynska, A., Curyllo, B., Czamara, M., Danilowicz-Szymanowicz, L., Dolecka, B., Drelich, L., Dudzik-Richter, B., Dybala, T., Dziuba, M., Faron, W., Figura-Chmielewska, M., Frankiewicz, A., Gadzinski, W., Gasior, E., Gosciniecka, B., Gutknecht, P., Guziewicz, M., Jackun-Podlesna, A., Jaguszewska, G., Jankielewicz, J., Jaremczuk-Kaczmarczyk, A., Jargiello-Baszak, M., Jarzebowski, A., Jaskulska-Niedziela, E., Jaworska-Drozdowska, M., Kabat, J., Kaczmarzyk-Radka, A., Kalin, K., Kaliszczak, R., Kiliszek, M., Klata, M., Kluczewski, M., Kobielusz-Gembala, I., Kochanska, E., Kociolek, D., Kolodzinska, A., Komlo, A., Konopka, A., Korczowska, E., Kowal, E., Kowalczyk, H. K., Kremis, E., Kruczyk, D., Krzesiak-Lodyga, A., Krzyzanowski, M., Kurdzielewicz, W., Kustrzycka-Kratochwil, D., Lesniewska-Krynska, D., Leszczynski, J., Lewicka, E., Lichota, E., Lip, K., Loboz-Rudnicka, M., Luka, J., Lysek-Jozefowicz, A., Machnikowska, M., Majewska, K., Mariankowski, R., Markiewicz, A., Mazur, M., Metzgier-Gumiela, A., Miedlar, E., Mielcarek, M., Neubauer-Geryk, J., Niedek, J., Niemirycz-Makurat, A., Nowak, A., Nowak, S., Opielowska-Nowak, B., Ozgowicz, M., Pawelska-Buczen, A., Pawlik-Rak, E., Piotrowicz, R., Ptaszynski, P., Raczynska, A., Rogowski, W., Romanek, J., Romaszkiewicz, R., Rostoff, P., Roszczyk, N., Rozewska-Furmanek, D., Rychta, J., Rzyczkowska, B., Sidor, A., Skalska, J., Smichura, M., Splawski, M., Staneta, P., Staniszewska, E., Starak-Marciniak, J., Stopyra-Poczatek, M., Sukiennik-Kujawa, M., Szafranski, J., Szalecki, P., Szczepanska, A., Szkrobka, W., Szuchnik, E., Szulowska, A., Szumczyk-Muszytowska, G., Szwoch, M., Traczyk, T., Troszczynska, M., Trzcinski, G., Tybura, S., Walasik, P., Wegrzynowska, M., Wesolowska, K., Wieczorek, W., Wierzbicka, A., Wilczewski, P., Wilgat-Szecowka, M., Wojewoda, P., Wojnowski, L., Wrobel, M., Zakutynska-Kowalczyk, K., Zyczynska-Szmon, M., Eltishcheva, V., Libis, R., Tereshchenko, S., Popov, S., Kamalov, G., Belenky, D., Zateyshchikova, A., Kropacheva, E., Kolesnikova, A., Nikolaev, K., Egorova, L., Khokhlov, A., Yakupov, E., Poltavskaya, M., Zateyshchikov, D., Drapkina, O., Vishnevsky, A., Barbarash, O., Miller, O., Aleksandrova, E., Chizhov, P., Sergeev, M., Shutemova, E., Mazur, E., Zrazhevskiy, K., Novikova, T., Kostenko, V., Moiseeva, Y., Polkanova, E., Sobolev, K., Rossovskaya, M., Zubeeva, G., Shapovalova, Y., Nagibovich, O., Edin, A., Agakhanyan, A., Batalov, R., Belenkova, Y., Bitakova, F., Chugunnaya, S., Dumikyan, A., Erofeeva, S., Gorbunova, E., Gorshkova, T., Gubanov, A., Gurmach, M., Ivanova, Y., Kolesova, T., Konyushenko, D., Korneeva, O., Kropova, O., Kuchuk, P., Kungurtseva, O., Kupriyanova, T., Kurylo, B., Kuvanova, M., Lebedeva, O., Lileeva, E., Machilskaya, O., Medvedeva, T., Monako, G., Motylev, I., Nagibovich, G., Novikova, E., Orlov, Y., Osmolovskaya, Y., Ovsannikova, A., Platonov, D., Rachkova, S., Sinitsina, O., Speshilova, S., Suslova, O., Ushakov, A., Volodicheva, O., Zemlianskaia, O., Zhirov, I., Zhuravleva, E., Zotova, I., Garcia, P. A., Fernandez, M. F. L., Tercedor, L., Iparraguirre, S. T., Monserrat, P. T., Contreras, E. M., Rafecas, J. I., Carrasco, J. M., Pavia, P. G., Pajuelo, C. G., Serrano, C. M., Alonso, L. F. I., Ruiz, A. G., Klein, J. M., Juanatey, J. R. G., Esquivias, G. B., Collado, I. M., Piquero, H. P., Cuixart, C. B., Morato, M. R., Llibre, J. B. I., Vicente, C. C., Gutierrez, M. V., Gonzalo, F. E., Fernandez, C. A. A., Plana, N. D. V., Montserrat, E. E., Alia, J. J. M., Oliva, M. A. M., Sanmartin, J. I., Gonzalez, M. J., Alvarez, M. R., Melenchon, J. H., Vera, T. R., Soriano, F. R., Riesco, L. G., Macian, M. D. M., Granado, J. Q., Navarro, M. J., Sales, J. C., Perez, J. V. V., Caamano, M. V., Torres, M. F. A., Gomez, G. M., Romo, A. I., Diaz, M. A. P., Alonso, C., Alvarez, D., Alvarez, M., Amaro, M., Andere, N., Villar, J. A., Ochoa, R. A., Austria, A., Barbeira, S., Feu, E. B., Bartes, A., Munoz, V. B., Jimenez, F. J. B., Tijuan, A. B., Ramirez, J. C., Ramos, M. C., Martinez, E. C., Moreno, M. C., Corchado, G. C., Gil, M. C., Orive, M. C., Fernandez, D. C., del Misterio, M. C., Alsina, R. C., Cabrera, A. C., de Faria, J. C. P. P., Costas, S., Marco, M. I. C., Dachs, M., Lopez, C. M. D., Borras, A. D., Madariaga, A. E., Espallargas, A., Fernandez, M., Escobar, E. F., Mas, E. F., Ferrer, A., Fosch, J., Bermudez, M. G., Millan, V. G., Saenz, M. G., Garcia, C. G., Gomez, C., Perez, Y. G., Segovia, A. G., Gonzalez, P., Grigorian, L., Molina, A. G., del Val, M. C. G., Maeso, B. H., Rodriguez, E. H., Garcia, A. I., Fernandez, M. J. J., Besa, B. J., Salvadores, P. J., Bouzamayor, M. B. L., Lasuncion, I., Gort, L. E. L., Molina, M. L., Lopez, M., Rey, A. M., Guerra, J. M., Marcus, S., Vila, A. M., Mena, M. M., Mazon, P., Zurita, F. M., Millan, G., Molina, M., Alia, P. M., Montes, D., Gonzalez, M. M., Munoz, R. B. M., Palma, A. N., Figueroa, H. N. O., Ortega, V. M., Cortes, C. O., Tomera, D. O., Merchan, N. P., Ibar, I. P., Garcia, E. P., Armayor, M. P., Carasa, M. P., Prieto, I., Quintern, V., Renom, R., Diaz, L. M. R., Rios, V., Sola, L. R., Rivera, R., Robiro, X. R., Roca, M., Saumell, C. R., Rodrigo, C., Rodriguez, E., Garcia, M. R., Jimenez, S. S., Calderon, P. S., Mendez, L. S., Parra, S. S., Santolaya, C., Sanz, M. R. S., Blanco, A. S., Serralvo, E., Sierra, N., Valero, C. S., Lopez, J. S., Fontanillas, M. T., Riera, M. T., Tobajas, G., Torres, C., Marques, J. T., Pastor, M. U., Wirdby, A., Linden, J., Henriksson, K., Elmersson, M., Egilsson, A., Borjesson, U., Svard, G., Liu, B., Lindh, A., Olsson, L. -B., Gustavsson, M., Andersson, L., Benson, L., Bothin, C., Hajimirsadeghi, A., Kadir, K., Ericsson, M., Ohlsson, A., Lindvall, H., Svensson, P., Thorne, K., Handel, H., Platonov, P., Eriksson, B., Timberg, I., Romberg, K., Crisby, M., Karlsson, J. -E., Jensen, S. A., Andersson, A., Malmqvist, L., Martinsson, B., Bernsten, F., Engdahl, J., Thulin, J., Hot-Bjelac, A., Stalby, P., Aaroe, H., Ahbeck, E., Ahlmark, H., Al-Khalili, F., Bonkowski, G., Dzeletovic, S., Ekstrand, A. -B., Eriksson, G. -B., Floren, K., Grassjo, C., Hahn, S., Jaensson, P., Jansson, B., Jansson, J. -H., Kangert, R. -M., Koch, A., Kusiak, D., Lettenstrom, A., Lindberg, A., Lindholm, C. -J., Mannermyr, A., Mansson, K., Millborg, M., Nilsson, C., Ohlin, A. -M., Olofsson, A., Osberg, A., Pedersen, A., Risbecker, K., Rosenberg, K., Samuelsson, J., Shayesteh, M., Skoglund, K., Stjernberg, M., Thorsen, C., Beer, J. H., Debrunner, J., Amstutz, D., Bruegger, J., Elise, G., Grau, A., Guinand, A., Henriette, I., Saga, E., Winnik, S., Rudyk, I., Tseluyko, V., Karpenko, O., Zhurba, S., Kraiz, I., Kupnovytska, I., Serediuk, N., Mostovoy, Y., Ushakov, O., Koval, O., Kovalskyi, I., Svyshchenko, Y., Sychov, O., Stanislavchuk, M., Kraydashenko, O., Yagensky, A., Tykhonova, S., Fushtey, I., Belegai, R., Berko, G., Burdeuna, L., Chabanna, O., Daniuk, I., Ivanov, A., Kamenska, E., Kaplan, P., Khyzhnyak, O., Kizim, S., Matova, O., Medentseva, O., Mochonyi, V., Mospan, M., Nemtsova, V., Ovdiienko, T., Palamarchuk, O., Pavelko, M., Petrovskyy, R., Plevak, D., Proshak, O., Pyvovar, S., Rasputina, L., Romanenko, O., Romanova, O., Sapatyi, A., Shumakov, O., Stets, R., Todoriuk, L., Varenov, V., Chauhan, N., Goodwin, D., Saunders, P., Evans, R., Leese, J., Jhittay, P. S., Ross, A., Kainth, M. S., Pickavance, G., Mcdonnell, J., Williams, A., Gooding, T., Wagner, H., Suryani, S., Singal, A., Sircar, S., Bilas, R., Hutchinson, P., Wakeman, A., Stokes, M., Paul, N., Aziz, M., Ramesh, C., Wilson, P., Franklin, S., Fairhead, S., Thompson, J., St Joseph, V., Taylor, G., Tragen, D., Seamark, D., Paul, C., Richardson, M., Jefferies, A., Sharp, H., Jones, H., Giles, C., Page, M., Oginni, O., Aldegather, J., Wetherwell, S., Lumb, W., Evans, P., Scouller, F., Macey, N., Stipp, Y., West, R., Thurston, S., Wadeson, P., Matthews, J., Pandya, P., Gallagher, A., Railton, T., Sinha, B., Russell, D., Davies, J. A., Ainsworth, P., Jones, C. P., Weeks, P., Eden, J., Kernick, D., Murdoch, W., Lumley, L., Patel, R. P., Wong, S. W., Saigol, M., Ladha, K., Douglas, K., Cumberlidge, D. F., Bradshaw, C., Van Zon, G., Jones, K. P., Thomas, M. J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A. R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J. L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N. I., Thompson, R., Chigbo, C., Zaidi, S. M. A., Howard, M., Butter, K. C., Barrow, S., Little, H., Haq, I. U., Gibbons, L., Glencross, S., Mcleod, A. J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R. N., Lowe, S., Kamath, R., Dau, H. S., Webster, J., Hodgins, I., Vercoe, S., Roome, P. C., Pinnock, H., Patel, J. R. A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C. A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A. C., Sabir, A., Choudhary, F., Khalaque, S., Wilson, A., Peters, S., Coulson, W., Roberts, N., Heer, A., Coates, S., Ward, B., Jackson, D., Walton, S., Shepherd, D., Sterry, M., Wong, T., Boon, M., Bunney, R., Haria-Shah, R., Baron, R. T., Davies, S., Schatzberger, T., Hargreaves, N., Stephenson, T., Choi, H., Batson, R., Lucraft, L., Myhill, T., Estifano, S., Geatch, D., Wilkinson, J., Veale, R., Forshaw, K., Davies, T., Zaman, K., Vinson, P., Liley, C., Bandrapalli, M., Mcginty, P., Wastling, R., Mceleny, P., Beattie, A., Cooke, P., Wong, M., Gunasegaram, J., Pugsley, M., Ahmad, S., A'Court, C., Ayers, J., Bennett, J., Cartwright, S., Dobson, S., Dooldeniya, C., Flynn, A., Fox, R., Goram, J., Halpin, A., Hay, A., Jacobs, P., Jeffers, L., Lomax, L., Munro, I., Muvva, R., Nadaph, M., Powell, K., Randfield, S., Redpath, D., Reed, R., Rickenbach, M., Rogers, G., Saunders, P. B., Seamark, C., Shewring, J., Simmons, P., Simper, H., Stoddart, H., Sword, A., Thomas, N., Thomson, A., Blenkhorn, A., Singh, B., Van Gaal, W., Abhayaratna, W., Lehman, R., Roberts-Thomson, P., Kilian, J., Coulshed, D., Catanchin, A., Colquhoun, D., Kiat, H., Eccleston, D., French, J., Zimmett, L., Ayres, B., Phan, T., Blombery, P., Crimmins, D., O'Donnell, D., Choi, A., Astridge, P., Arstall, M., Jepson, N., Binnekamp, M., Lee, A., Rogers, J., Starmer, G., Carroll, P., Faunt, J., Aggarwala, A., Barry, L., Batta, C., Beveridge, R., Black, A., Bonner, M., Boys, J., Buckley, E., Campo, M., Carlton, L., Connelly, A., Conway, B., Cresp, D., Dimitri, H., Dixon, S., Dolman, M., Duroux, M., Eskandari, M., Eslick, R., Ferreira-Jardim, A., Fetahovic, T., Fitzpatrick, D., Geraghty, R., Gibbs, J., Grabek, T., Modi, M. H., Hayes, K., Hegde, M. P., Hesketh, L., Hoffmann, B., Johnson, K., Juergens, C., Kassam, I., Lawlor, V., Lehman, M., Lehman, S., Leung, D., Mackay, S., Mackenzie, M., Mccarthy, C., Mcintosh, C., Mckeon, L., Morrison, H., Mussap, C., Myers, J. -D., Nagalingam, V., Oldfield, G., O'May, V., Palmer, J., Parsons, L., Patching, K., Patching, T., Paul, V., Plotz, M., Preston, S., Rashad, H., Ratcliffe, M., Raynes, S., Rose, J., Sanders, L., Seremetkoska, M., Setio, H., Shone, S., Shrestha, P., Singh, C., Singleton, C., Stoyanov, N., Sutcliffe, S., Swaraj, K., Tarrant, J., Thompson, S., Tsay, I. M., Vorster, M., Waldman, A., Wallis, L., Wilford, E., Wong, K., Luton, R., Gupta, M., Pandey, A. S., Cheung, S., Leader, R., Beaudry, P., Ayala-Paredes, F., Berlingieri, J., Heath, J., Poirier, G., Du Preez, M., Nadeau, R., Dresser, G., Dhillon, R., Hruczkowski, T., Schweitzer, B., Coutu, B., Angaran, P., Macdonald, P., Vizel, S., Fikry, S., Parkash, R., Lavoie, A., Cha, J., Ramjattan, B., Bonet, J., Ahmad, K., Aro, L., Aves, T., Beaudry, K., Bergeron, C., Bigcanoe, J., Bignell, N., Breakwell, L., Burke, E., Carroll, L., Clarke, B., Cleveland, T., Daheb, S., Dehghani, P., Denis, I., Djaidani, Z., Dorian, P., Douglass, S., Dunnigan, J., Ewert, A., Farquhar, D., Fearon, A., Ferleyko, L., Fournier, D., Fox, B., Grenier, M. -C., Gulliver, W., Haveman, K., Hines, C., Hines, K., Jackson, A. M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., El-Aziz, A. A., Seif, S. K. A., El Din, M. G., El Etriby, S., Elbahry, A., El-Etreby, A., Elkhadem, M., Katta, A., Khairy, T., Mowafy, A., Nawar, M., Ohanissian, A., Reda, A., Reda, M., Salem, H., Sami, N., Samir, S., Setiha, M., Sobhy, M., Soliman, A., Taha, N., Tawfik, M., Zaatout, E., Kettles, D., Bayat, J., Siebert, H., Horak, A., Kelfkens, Y., Garda, R., Pillay, T., Guerra, M., van Zyl, L., Theron, H., Murray, A., Louw, R., Greyling, D., Mntla, P., Ueckermann, V., Loghdey, R., Ismail, S., Ahmed, F., Engelbrecht, J., Ramdass, A., Maharajh, S., Oosthuysen, W., Angel, G., Bester, C., Booysen, M., Boshoff, C., Cannon, C., Cassimjee, S., Chami, C., Conway, G., Davids, A., de Meyer, L., Du Plessis, G., Ellis, T., Henley, L., Karsten, M., Loyd, E., Marks, J., Mavhusa, L., Mostert, M., Page, A., Rikhotso, L., Salie, M., Sasto, J., Shaik, F., Skein, A., Smith, L., Tarr, G., Tau, T., van Zyl, F., Yousef, G., Agrawal, A., Nathani, M., Ibrahim, M., Esheiba, E. M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W. M., Cox, M., Franco, M., Falkowski, S., Mendelson, R., Williams, M., Miller, S., Beach, S., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., Depauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J. A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.

Subjects
Registrie, Male, Latin Americans, 030204 cardiovascular system & hematology, outcomes, 0302 clinical medicine, Drug Prescription, Retrospective Studie, Risk Factors, Atrial Fibrillation, Antithrombotic, Prospective Studies, Registries, 030212 general & internal medicine, Practice Patterns, Physicians', Stroke, Anticoagulant, Atrial fibrillation, General Medicine, Middle Aged, Treatment Outcome, Stroke prevention, outcome, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Human, medicine.medical_specialty, medicine.drug_class, Clinical Investigations, Hemorrhage, antithrombotic treatment, Drug Prescriptions, 03 medical and health sciences, Internal medicine, medicine, Humans, Mexico, Aged, Retrospective Studies, Fibrillation, business.industry, Risk Factor, Anticoagulants, South America, medicine.disease, Drug Utilization, Clinical trial, Prospective Studie, Latin American, antithrombotic treatment, atrial fibrillation, Latin American, outcomes, business
Abstract

Author(s): Jerjes-Sanchez, Carlos; Corbalan, Ramon; Barretto, Antonio CP; Luciardi, Hector L; Allu, Jagan; Illingworth, Laura; Pieper, Karen S; Kayani, Gloria; GARFIELD-AF Investigators | Abstract: BackgroundAtrial fibrillation (AF) is an important preventable cause of stroke. Anticoagulation (AC) therapy can reduce this risk. However, prescribing patterns and outcomes in patients with non-valvular AF (NVAF) from Latin American countries are poorly described.MethodsUsing data from the Global Anticoagulant Registry in the FIELD-AF (GARFIELD-AF), we examined the stroke prevention strategies and the 1-year outcomes in patients from four Latin American countries: Argentina, Brazil, Chile, and Mexico.ResultsA total of 4162 patients (2010-2014) were included in this analysis. At the time of AF diagnosis, 39.9% of patients were prescribed vitamin K antagonists (VKA) ± antiplatelet (AP) therapy, 21.8% non-VKA oral anticoagulant (NOAC) ± AP, 24.1% AP only and 14.1% no antithrombotic treatment. The proportion of moderate-high risk patients receiving no AC therapy at participating centers was highest in Mexico (46.4%) and lowest in Chile (14.3%). During 1-year follow-up, the rates of all-cause mortality, stroke/SE and major bleeding were: 5.77 (95% CI) (5.06-6.56), 1.58 (1.23-2.02), and 0.99 (0.72-1.36) and per 100 person-years, respectively, which are higher than the global rates across all countries in GARFIELD-AF. Unadjusted rates of all-cause mortality were highest in Argentina, 6.95 (5.43-8.90), and lowest in Chile, 4.01 (2.92-5.52).ConclusionsGARFIELD-AF results describes the marked variation in the baseline characteristics and patterns of antithrombotic treatments in patients with NVAF in four Latin American countries. Over one-third of patients with a moderate-to-high risk of stroke received no AC therapy, highlighting the need for improved management of patients according to national guideline. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362.

Published
2019

38. Etiological factors and characterization of patients with lung cancer at the National Cancer Institute, Paraguay

Author

Cinthia Gauna, Miguel Antonio Agüero, Silvia Josefina Ayala León, and Miguel Ayala León

Subjects
Oncology, medicine.medical_specialty, carcinógenos ambientales, pulmonary neoplasms, business.industry, neoplasias pulmonares, Cancer, General Medicine, medicine.disease, smoking, environmental carcinogens, tabaquismo, Internal medicine, medicine, Etiology, business, Lung cancer
Abstract

RESUMEN Introducción: el cáncer de pulmón es un problema de Salud Pública en el mundo y en nuestro país por su alta mortalidad e incidencia. Los carcinógenos medioambientales y el tabaquismo están directamente relacionados como factores de riesgo. Objetivo: Caracterizar los factores etiológicos de fumador activo y carcinógenos medioambientales de los pacientes con cáncer de pulmón detectados durante 9 años en el Instituto Nacional del Cáncer, Paraguay. Metodología: estudio observacional retrospectivo descriptivo analítico de una base de datos del período 2004-2013. Las variables medidas fueron datos demográficos, carga tabáquica, tabaquismo, la exposición a carcinógenos medioambientales categoría I. Resultados: se incluyeron 478 pacientes con cáncer pulmonar, 88,1% de sexo masculino y 11,9% femenino. La edad promedio del sexo masculino fue 60±10 años y del sexo femenino 58±12 años. La prevalencia de exposición carcinógenos medioambientales categoría I fue 36,90%. La media del índice tabáquico fue 4,48±20. El modelo de regresión lineal múltiple entre exposición ambiental, tabaquismo y tipo histológico para predecir la severidad clínica fue 3,6%. En el análisis de regresión logística de la relación de tipos histológicos con tabaquismo, género y exposición ambiental no mejoran el modelo de predicción. Conclusiones: Los factores etiológicos relacionados con carcinógenos medioambientales estuvieron presentes en más de un tercio de la población, el hábito tabáquico es mayor en hombres que en mujeres. El tipo histológico más frecuente para ambos sexos, con y sin el hábito tabáquico, es el carcinoma de células no pequeñas. ABSTRACT Introduction: Lung cancer is a public health problem in the world and in our country due to its high mortality and incidence. Environmental carcinogens and smoking are directly related as risk factors. Objective: To characterize the etiological factors of active smokers and environmental carcinogens of patients with lung cancer detected during 9 years at the National Cancer Institute, Paraguay. Methodology: Retrospective observational descriptive analytical study of a database for the period 2004-2013. The variables measured were demographic data, smoking load, smoking, exposure to category I environmental carcinogens. Results: Four hundred seventy-eight patients with lung cancer, 88.1% male and 11.9% female were included. The mean age of the male sex was 60±10 years and 58±12 years of the female age. The prevalence of exposure to category I environmental carcinogens was 36.90%. The mean smoking index was 4.48±20. The multiple linear regression model between environmental exposure, smoking and histological type to predict clinical severity was 3.6%. In the logistic regression analysis of the relationship of histological types with smoking, gender and environmental exposure, the prediction model was not improved. Conclusions: The etiological factors related to environmental carcinogens were present in more than one third of the population, and smoking was greater in men than in women. The most frequent histological type for both sexes, with and without the smoking habit, was non-small cell carcinoma.

Published
2020

39. Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance

Author

Allegra Kawles, Sara R. Dunlop, Margaret E. Flanagan, Changiz Geula, Tamar Gefen, Ivan Ayala, and M.-Marsel Mesulam

Subjects
Lewy Body Disease, Basal Forebrain, Degeneration (medical), Biology, Biochemistry, Article, Choline O-Acetyltransferase, Cellular and Molecular Neuroscience, Alzheimer Disease, mental disorders, medicine, Animals, Humans, Dementia, Receptors, Cholinergic, Cholinergic neuron, Basal forebrain, nutritional and metabolic diseases, Frontotemporal lobar degeneration, Resilience, Psychological, medicine.disease, Cholinergic Neurons, nervous system diseases, medicine.anatomical_structure, Tauopathies, Cerebral cortex, Nerve Degeneration, Cholinergic, Disease Susceptibility, Tauopathy, Frontotemporal Lobar Degeneration, Neuroscience
Abstract

The basal forebrain cholinergic neurons (BFCN) provide the primary source of cholinergic innervation of the human cerebral cortex. They are involved in the cognitive processes of learning, memory, and attention. These neurons are differentially vulnerable in various neuropathologic entities that cause dementia. This review summarizes the relevance to BFCN of neuropathologic markers associated with dementias, including the plaques and tangles of Alzheimer's disease (AD), the Lewy bodies of diffuse Lewy body disease, the tauopathy of frontotemporal lobar degeneration (FTLD-TAU) and the TDP-43 proteinopathy of FTLD-TDP. Each of these proteinopathies has a different relationship to BFCN and their corticofugal axons. Available evidence points to early and substantial degeneration of the BFCN in AD and diffuse Lewy body disease. In AD, the major neurodegenerative correlate is accumulation of phosphotau in neurofibrillary tangles. However, these neurons are less vulnerable to the tauopathy of FTLD. An intriguing finding is that the intracellular tau of AD causes destruction of the BFCN, whereas that of FTLD does not. This observation has profound implications for exploring the impact of different species of tauopathy on neuronal survival. The proteinopathy of FTLD-TDP shows virtually no abnormal inclusions within the BFCN. Thus, the BFCN are highly vulnerable to the neurodegenerative effects of tauopathy in AD, resilient to the neurodegenerative effect of tauopathy in FTLD and apparently resistant to the emergence of proteinopathy in FTLD-TDP and perhaps also in Pick's disease. Investigations are beginning to shed light on the potential mechanisms of this differential vulnerability and their implications for therapeutic intervention.

Published
2021

40. Psychometric evaluation of the Substance Abuse Subtle Screening Inventory-3 with Northern Plains American Indians

Author

Jacqueline S. Gray, Evelyn Ayala, and Thomas V. Petros

Subjects
Psychometrics, Screening test, Substance-Related Disorders, business.industry, PsycINFO, medicine.disease, Sensitivity and Specificity, Mental health, Substance abuse, Clinical Psychology, Substance Abuse Subtle Screening Inventory, Internal consistency, Indians, North American, Predictive power, medicine, Humans, Mass Screening, Medical diagnosis, business, American Indian or Alaska Native, Applied Psychology, Clinical psychology
Abstract

The efficacy of the Substance Abuse Subtle Screening Inventory-3 (SASSI-3) was assessed among northern plains American Indians (AIs). The current study examined the efficacy of the SASSI-3 for identification of substance abuse in AIs. Northern plains AIs from 7 reservations participated in the study. The participants were either a clinical sample receiving substance abuse (SA) or mental health diagnoses from behavioral health clinicians and receiving outpatient treatment services or a community sample that had no substance abuse or mental health diagnoses and were not currently in treatment (no diagnosis). The internal consistency for Face Valid Alcohol (FVA), Face Valid Other Drugs, and Symptoms (SYM) subscales were excellent, and the consistency for the other subscales was moderate, ranging from .21 to 73. The results of the study suggest that the SASSI-3 has good positive predictive power (PPP) and negative predictive power (NPP), particularly when the criterion group substance abuse is larger in the sample. Additionally, the PPP and NPP varied depending on the decision rules. For the analysis that included individuals with just SA, the clinical group scored significantly higher than the no diagnosis group on all measures of the SASSI-3, except for Defensiveness. When the SA group included all individuals with the diagnosis (regardless of the comorbid diagnosis), the clinical group scored significantly higher than the no diagnosis group for all the SASSI-3 subscales. A discriminant examination of the standardized function coefficients indicated that the FVA and SYM subtests contributed the most to the function. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Published
2021

41. Salivary proteome of aphthous stomatitis reveals the participation of vitamin metabolism, nutrients, and bacteria

Author

Esteban Núñez, Paola Andrea Camargo-Ayala, Alfredo Pereira, César Rivera, Fabiane M. Nachtigall, Mariagrazia Muñoz, Jenaro Garcia-Huidobro, Leonardo S. Santos, and Romina Hernández-Olivos

Subjects
0301 basic medicine, Vitamin, Saliva, Proteome, Science, Dental diseases, Proteomics, medicine.disease_cause, Recurrent aphthous stomatitis, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Western blot, Recurrence, medicine, Oral diseases, Humans, Aphthous stomatitis, Stomatitis, Multidisciplinary, medicine.diagnostic_test, business.industry, Neisseria meningitidis, 030206 dentistry, Vitamins, medicine.disease, Pathophysiology, stomatognathic diseases, 030104 developmental biology, chemistry, Immunology, Medicine, Stomatitis, Aphthous, business
Abstract

There are currently no preventative options for recurrent aphthous stomatitis, and the only available treatments are palliative. This is partly due to a poor understanding of its etiopathogenesis. In this case-control study, we characterized the salivary proteome of patients with recurrent aphthous stomatitis in the presence and absence of lesions. Through mass spectrometry-based proteomics and bioinformatics tools, we identified that the presence of oral ulcers is associated with several specific biological processes, including the metabolic pathways of vitamin B9, B12, nitrogen, selenium, and the bacterium Neisseria meningitidis. These changes occurred only in the presence of clinically visible lesions, and there were no relevant differences between patients in anatomical regions unaffected by ulcers. Additionally, using western blot and ELISA assays, we verified that carbonic anhydrase 1 (CA1, UniProtKB - P00915, CAH1_HUMAN) and hemoglobin subunit beta (HBB, UniProtKB - P68871, HBB_HUMAN) proteins are highly expressed during the ulcerative and remission phases of recurrent aphthous stomatitis. Our results cumulatively support saliva as an indicator of the pathophysiological changes, which occur during the clinical course of lesions. From a clinical perspective, we suggest that recurrent aphthous stomatitis is a condition triggered by temporary biological changes in people with lesions.

Published
2021

42. Association between maternal hypertensive disorders, fetal growth and childhood learning outcomes

Author

Melissa A. Clark, Nina K. Ayala, Patrick M. Vivier, Erika F. Werner, Lauren E. Schlichting, Samara Viner-Brown, and Marga Kempner

Subjects
Adult, medicine.medical_specialty, education, Birth certificate, Cohort Studies, Fetal Development, Young Adult, Pre-Eclampsia, Pregnancy, Prenatal Diagnosis, Internal Medicine, medicine, Humans, Maternal hypertension, cardiovascular diseases, Child, reproductive and urinary physiology, Retrospective Studies, Obstetrics, Infant, Newborn, Pregnancy Outcome, Rhode Island, Obstetrics and Gynecology, Gestational age, Retrospective cohort study, medicine.disease, female genital diseases and pregnancy complications, Neurodevelopmental Disorders, Relative risk, Infant, Small for Gestational Age, Cohort, Small for gestational age, Female
Abstract

Objective Both small for gestational age (SGA) birthweight and pregnancies complicated by maternal hypertension (HTN) are independently associated with poorer childhood learning outcomes, however the relative contribution of each remains unknown. Study design A retrospective cohort was created in which 2014–2017 third grade Rhode Island Department of Education data were linked to Rhode Island Department of Health birth certificate data. The study population was composed of non-anomalous, singleton births between 22- and 42-weeks’ gestation. Reading and math proficiency were compared among four groups: 1) appropriate for gestational age (AGA) and no maternal HTN (referent), 2) AGA with HTN, 3) SGA without HTN and 4) SGA with HTN. Main outcome measures Bivariable and multivariable log-binomial regression were used to examine the association between subject proficiency and pregnancy complication, adjusting for potential confounders. Results Of the 23,097 who met inclusion criteria, 1004 (4%) were AGA with HTN, 1575 (7%) were SGA without HTN and 176 (1%) were SGA with HTN. Overall, when adjusted for maternal age, gestational age, sex and socioeconomic factors, only children born SGA without HTN had reduced reading proficiency (relative risk (RR) 0.86 95% confidence interval (CI) 0.78, 0.92) and math proficiency (RR 0.88 95% CI 0.82, 0.94) compared to children born AGA without HTN. Conclusion In a diverse, statewide cohort, only SGA without HTN was associated with lower reading and math proficiency compared to uncomplicated pregnancies. This suggests that only decreased fetal growth from causes other than HTN is associated with risk of poorer school-age outcomes, and has implications for early resource allocation.

Published
2021

43. Impact of the COVID-19 pandemic on the activity of advanced-practice nurses on a reference unit for inflammatory bowel disease

Author

Irene Joana Batuecas Duelt, sara López Branchadell, Jorge García Alcaide, Natalia Borruel, V. Robles, Ester Navarro-Correal, Zahira Pérez Martínez, Arantxa Ibarz Casas, Luis Fernando Mayorga Ayala, Sandra Agustino Rodríguez, Esperanza Zuriguel-Pérez, Francesc Casellas, and Claudia Herrera-de Guise

Subjects
Adult, Male, Telesalud, Telemedicine, medicine.medical_specialty, Occupational prestige, UACC, Crohn-Colitis Care Unit, Telehealth, Disease, Inflammatory bowel disease, Unit (housing), Advanced-practice nurses, Crohn Disease, Colitis ulcerosa, Pandemic, Humans, Medicine, TA, Telematic Assistance, Enfermedad de Crohn, Pandemics, Retrospective Studies, Analysis of Variance, Chi-Square Distribution, Electronic Mail, Hepatology, business.industry, Gastroenterology, COVID-19, Retrospective cohort study, Telemedicina, Middle Aged, Enfermeras de práctica avanzada, Symptom Flare Up, medicine.disease, Telephone, Crohn's disease, Ulcerative colitis, Enfermedad inflamatoria intestinal, Spain, Emergency medicine, Original Article, Colitis, Ulcerative, Female, business, AIN, Advanced IBD Nurse
Abstract

Objective To report the impact of the COVID-19 pandemic on the activity of nurses working on an inflammatory bowel disease (IBD) unit and to identify reasons for telehealth care and its relationship to certain characteristics. Background The COVID-19 pandemic had led to an increase in demand for remote care in patients with inflammatory bowel disease who require monitoring and frequent access to health services. Design – methods A retrospective study of all activity (in person and by phone call or email) done on the unit during the acute phase of the pandemic at a reference hospital in Spain. Numbers of activities done by nurses, reasons for telehealth care and sociodemographic and clinical data were collected. Statistical analysis was performed using frequency, chi-squared and analysis of variance tests. Results A total of 1095 activities for 561 patients who received care were reported. Among them, 1042 (95.2%) were telemedicine activities, amounting to a 47.3% increase over the prior year. COVID-19-related activities numbered 588 (59.5%). Consultations due to disease flare-up numbered 134 (13.7%), representing a 145% increase compared to 2019. Significant differences were found between reasons for using telemedicine and diagnosis, occupational status, contact week and treatment. Conclusion The acute phase of the pandemic has changed the activity managed by the nursing staff on the unit. Identifying and analysing these changes has yielded valuable information to achieve more efficient management and better care quality for patients in special situations.

Published
2021

44. Treatment of <scp> CSF1R </scp> ‐Related Leukoencephalopathy: Breaking New Ground

Author

Daniel L. Kenney-Jung, Daniel F. Broderick, David Nascene, Zbigniew K. Wszolek, Erik H. Middlebrooks, Balvindar Singh, Ernesto Ayala, Shernan G. Holtan, Beth K. Rush, Philip W. Tipton, and Troy C. Lund

Subjects
Pediatrics, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Neuropsychology, Brain, Neurodegenerative Diseases, Neurological examination, Disease, Hematopoietic stem cell transplantation, medicine.disease, White Matter, Leukoencephalopathy, Neurology, Leukoencephalopathies, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Cohort, medicine, Humans, Brain magnetic resonance imaging, In patient, Neurology (clinical), business
Abstract

Background Colony-stimulating factor-1 receptor (CSF1R)-related leukoencephalopathy is a rapidly progressive neurodegenerative disease for which there is currently no cure. Hematopoietic stem cell transplantation (HSCT) has been proposed as a disease-modifying treatment. Objective The objective of this study was to determine the effect of HSCT on disease progression. Methods We collected all available clinical data from a cohort of 7 patients with CSF1R-related leukoencephalopathy who underwent HSCT at our institutions. Clinical data included detailed neurological examination by a board-certified neurologist, serial cognitive screens, formal neuropsychological evaluations, and serial brain magnetic resonance imaging (MRI). Results Our patients had an average disease duration of 27.6 months at the time of transplant, and we have 87 months of total posttransplant follow-up time (median, 11; range, 2-27). One patient died in the periprocedural period. The remaining patients showed a variable response to treatment, with 6 of 7 patients trending toward stabilization on motor examination, cognitive scores, and/or MRI abnormalities, especially with white matter lesion burden. Conclusions This is the largest series of patients with CSF1R-related leukoencephalopathy receiving HSCT. We conclude that HSCT can stabilize the disease in some patients. Variability in patient responsiveness suggests that measures of disease heterogeneity and severity need to be considered when evaluating a patient's candidacy for transplant. HSCT appears to be the first disease-modifying therapy for CSF1R-related leukoencephalopathy. This milestone may serve as a foothold toward better understanding the disease's pathomechanism, thus providing new opportunities for better disease-specific therapies. © 2021 International Parkinson and Movement Disorder Society.

Published
2021

45. Auditory and olfactory findings in patients with <scp> USH2A </scp> ‐related retinal degeneration—Findings at baseline from the rate of progression in <scp> USH2A </scp> ‐related retinal degeneration natural history study ( <scp>RUSH2A</scp> )

Author

Paul S. Bernstein, Wadih M. Zein, Katarina Stingl, Isabelle Audo, Alessandro Iannaccone, Richard L. Doty, Gavin M. Bidelman, Mark H. Myers, Janet K. Cheetham, Carmen C. Brewer, Todd Durham, Jacque L. Duncan, Robert B. Hufnagel, Peiyao Cheng, Allison R Ayala, and Maureen G. Maguire

Subjects
Retinal degeneration, education.field_of_study, medicine.medical_specialty, Hearing loss, business.industry, Usher syndrome, Population, Olfaction, Audiology, medicine.disease, eye diseases, otorhinolaryngologic diseases, Genetics, medicine, Sensorineural hearing loss, Autosomal recessive retinitis pigmentosa, medicine.symptom, education, business, Genetics (clinical), Natural history study
Abstract

Sensorineural hearing loss (SNHL) is characteristic of Usher syndrome type 2 (USH2), but less is known about SNHL in nonsyndromic autosomal recessive retinitis pigmentosa (ARRP) and olfaction in USH2A-associated retinal degeneration. The Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) is a natural history study that enrolled 127 participants, 80 with USH2 and 47 with ARRP. Hearing was measured by pure-tone thresholds and word recognition scores, and olfaction by the University of Pennsylvania Smell Identification Test (UPSIT). SNHL was moderate in 72% of USH2 participants and severe or profound in 25%, while 9% of ARRP participants had moderate adult-onset SNHL. Pure-tone thresholds worsened with age in ARRP but not in USH2 participants. The degree of SNHL was not associated with other participant characteristics in either USH2 or ARRP. Median pure-tone thresholds in ARRP participants were significantly higher than the normative population (p < 0.001). Among 14 USH2 participants reporting newborn hearing screening results, 7 reported passing. Among RUSH2A participants, 7% had mild microsmia and 5% had moderate or severe microsmia. Their mean (±SD) UPSIT score was 35 (±3), similar to healthy controls (34 [±3]; p = 0.39). Olfaction differed by country (p = 0.02), but was not significantly associated with clinical diagnosis, age, gender, race/ethnicity, smoking status, visual measures, or hearing. Hearing loss in USH2A-related USH2 did not progress with age. ARRP patients had higher pure-tone thresholds than normal. Newborn hearing screening did not identify all USH2A-related hearing loss. Olfaction was not significantly worse than normal in participants with USH2A-related retinal degeneration.

Published
2021

46. A phase 2 trial of the histone deacetylase inhibitor panobinostat for graft-versus-host disease prevention

Author

Brian C. Betts, Joseph Pidala, Ram Thapa, Claudio Anasetti, Hugo F. Fernandez, Ernesto Ayala, Mohamed A. Kharfan-Dabaja, Lia Perez, Michael Nieder, Farhad Khimani, Leonel Ochoa-Bayona, Asmita Mishra, Frederick L. Locke, John Powers, Eva Sahakian, Alex Achille, and Xuefeng Wang

Subjects
Adult, 0301 basic medicine, medicine.medical_specialty, Transplantation Conditioning, medicine.medical_treatment, Peripheral edema, Graft vs Host Disease, Hematopoietic stem cell transplantation, Gastroenterology, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Panobinostat, Humans, Medicine, Cumulative incidence, Adverse effect, Aged, Transplantation, Leukopenia, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, Middle Aged, medicine.disease, Rash, Histone Deacetylase Inhibitors, 030104 developmental biology, Graft-versus-host disease, chemistry, 030220 oncology & carcinogenesis, medicine.symptom, business
Abstract

Immunomodulatory properties of histone deacetylase inhibitors represent a reasonable approach for acute graft-versus-host disease (aGVHD) prevention. We report a phase 2 trial evaluating panobinostat (PANO) administered over 26 weeks, starting on day −5 (5 mg orally 3 times a week) with tacrolimus initiated on day −3 plus sirolimus on day −1, with a median patient age of 58 years (range, 19-72 years) (n = 38). Donor source consisted of HLA 8/8–matched donors, related (n = 13) or unrelated (n = 25), using granulocyte colony-stimulating factor–stimulated peripheral blood stem cells. Myeloablative (n = 18) or reduced-intensity (n = 20) conditioning regimens were used for patients with acute myeloid leukemia (n = 17), myelodysplastic syndrome (n = 13), or other malignancies (n = 8). The cumulative incidence of aGVHD II-IV by day 100 was 18.4% (90% confidence interval [CI], 9.4% to 29.9%). Cumulative incidence of chronic GVHD at 1 year was 31.6% (90% CI, 19.5% to 44.3%). Adverse events related to PANO were thrombocytopenia (n = 5), leukopenia (n = 6), gastrointestinal toxicity (n = 3), rash (n = 4), renal failure/peripheral edema (n = 1), and periorbital edema (n = 1). At 1 year, overall survival was 89.5% (90% CI, 81.6% to 98.0%), relapse-free survival was 78.9% (90% CI, 68.8% to 90.6%), nonrelapse mortality was 2.6% (90% CI, 0.3% to 9.9%), and GVHD relapse-free survival was 60.5% (90% CI, 48.8% to 75.1%). PANO hits histone 3 as early as day 15 in CD8, CD4 and T regs. In conclusion, PANO combination met the primary study end point for aGVHD prevention and warrants further testing. This trial was registered at www.clinicaltrials.gov as #NCT02588339.

Published
2021

47. Spatial and Temporal Variability of Visceral Leishmaniasis in Colombia, 2007 to 2018

Author

Patricia Fuya, Giovanny Herrera, Martha S. Ayala, Adriana Castillo-Castañeda, and Juan David Ramírez

Subjects
Adult, medicine.medical_specialty, Time Factors, Distribution (economics), Disease, Colombia, Young Adult, Species Specificity, Public health surveillance, Virology, parasitic diseases, Epidemiology, medicine, Animals, Humans, Child, Aged, Retrospective Studies, Leishmania, Spatial Analysis, Poverty, business.industry, Infant, Tropical disease, Articles, Middle Aged, medicine.disease, Insect Vectors, Infectious Diseases, Geography, Visceral leishmaniasis, Child, Preschool, Leishmaniasis, Visceral, Parasitology, Spatial variability, Psychodidae, business, Demography
Abstract

Visceral leishmaniasis (VL) is a neglected tropical disease associated with poverty and is endemic in 56 countries worldwide. Brazil, Venezuela, and Colombia are the most affected countries in South America. In Colombia, the National Public Health Surveillance System (SIVIGILA) consolidates epidemiological information and monitors all VL cases nationwide. However, to date, no studies have investigated the occurrence of VL in Colombia using metadata analysis. We studied the demographic data, the spatial and temporal distribution of VL cases, and the association with vector distribution of Leishmania species in Colombia from 2007 to 2018. We found 306 VL cases reported to SIVIGILA for this period, with a coverage of 25.5 cases/year, and a mortality of 2.28% (seven deaths). The highest number of confirmed cases (N = 52) occurred in 2007; the lowest (N = 9) occurred in 2012. The cases were reported mainly in children (< 7 years) affiliated with the subsidized health regimen. Regarding the geographic distribution, the cases were reported by 42 municipalities distributed in 10 departments. The occurrence of VL cases toward the northeast of Colombia, and the distribution of vectors, such as Lutzomyia longipalpis and Lu. evansi, may be changing the panorama of VL in the country. We conclude that VL, mainly in recent years, shows a temporal and spatial variability associated with the occurrence of cases in new settings. Our findings increase our understanding and knowledge of this disease, and suggest the need to monitor and prioritize areas with changes in geographic expansion to improve prevention and control actions in the country.

Published
2021

48. Direct comparison of high-sensitivity cardiac troponin T and I in the early differentiation of type 1 vs. type 2 myocardial infarction

Author

Raphael Twerenbold, Luca Koechlin, Christian Müller, Tobias Zimmermann, F. Javier Martín-Sánchez, Pedro Lopez-Ayala, Damian Kawecki, Ketina Arslani, Òscar Miró, Jasper Boeddinghaus, Thomas Nestelberger, Desiree Wussler, Michael Freese, Karin Wildi, Paul David Ratmann, Therese Rinderknecht, Maria Rubini Gimenez, Nicolas Geigy, Patrick Badertscher, Apace Investigators, and Dagmar I. Keller

Subjects
medicine.medical_specialty, Cardiac troponin, Myocardial Infarction, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, 03 medical and health sciences, 0302 clinical medicine, Troponin T, Internal medicine, Clinical information, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Myocardial infarction, Cardiac imaging, Receiver operating characteristic, business.industry, General Medicine, Odds ratio, medicine.disease, Confidence interval, Clinical trial, Early Diagnosis, Cardiology, Cardiology and Cardiovascular Medicine, business, Biomarkers
Abstract

Aims To directly compare the diagnostic accuracy of high-sensitivity cardiac troponin (hs-cTn) T vs. hs-cTnI in the early non-invasive differentiation of Type 1 myocardial infarction (T1MI) due to plaque rupture and atherothrombosis from Type 2 myocardial infarction (T2MI) due to supply–demand mismatch. Methods and results In a prospective multicentre diagnostic study, two independent cardiologists centrally adjudicated the final diagnosis of T1MI vs. T2MI according to the fourth universal definition of myocardial infarction (MI), using all available clinical information including cardiac imaging in patients presenting with acute chest pain. Diagnostic accuracy was quantified by the area under the receiver operating characteristics curve (AUC). The most extensively validated hs-cTnT-Elecsys and hs-cTnI-Architect assays were measured at presentation, 1 h, and 2 h. Among 5887 patients, 1106 (19%) had a final diagnosis of MI, including 860 (78%) T1MI and 246 (22%) T2MI. The AUC of hs-cTnT-Elecsys to differentiate T1MI from T2MI was moderate and comparable to that provided by hs-cTnI-Architect: hs-cTnT-Elecsys AUC-presentation 0.67 [95% confidence interval (CI) 0.64–0.71], AUC-1 h 0.70 (95% CI 0.66–0.74), and AUC-2 h 0.71 (95% CI 0.66–0.75) vs. hs-cTnI-Architect AUC-presentation 0.71 (95% CI 0.67–0.74), AUC-1 h 0.72 (95% CI 0.68–0.76), and AUC-2 h 0.74 (95% CI 0.69–0.78), all P = not significant (NS). Similarly, the AUC of absolute changes was moderate and comparable for hs-cTnT-Elecsys and hs-cTnI-Architect (all P = NS). Cut-off concentrations achieving at least 90% specificity for the differentiation of T1MI vs. T2MI were >114 ng/L for hs-cTnT-Elecsys [odds ratio (OR) 4.2, 95% CI 2.7–6.6] and >371 ng/L for hs-cTnI-Architect (OR 4.0, 95% CI 2.6–6.2). Conclusion hs-cTnT-Elecsys and hs-cTnI-Architect provided comparable, albeit only moderate, diagnostic accuracy for the early differentiation of T1MI vs. T2MI. Clinical trial registration ClinicalTrials.gov number, NCT00470587, https://clinicaltrials.gov/ct2/show/NCT00470587.

Published
2021

49. Subcutaneous sarcoidosis: A case series of 19 patients

Author

M C Gonzalez-Vela, A E Lopez-Sundh, T Maestre-Orozco, and M Fernandez-Ayala

Subjects
medicine.medical_specialty, Systemic disease, skin, business.industry, Darier-Roussy's sarcoid, Less invasive, Mean age, General Medicine, Disease, medicine.disease, Lung involvement, Gastroenterology, subcutaneous nodules, Subcutaneous nodule, Internal medicine, medicine, Medicine, Subcutaneous sarcoidosis, Case Series, disease severity, Sarcoidosis, sarcoidosis, business
Abstract

Subcutaneous sarcoidosis is a rare variant of this disease, whose relationship with systemic disease is still controversial. Our objective was to describe the clinical characteristics of a series of patients with subcutaneous sarcoidosis and to investigate the relationship between these skin lesions and the disease's activity, severity, and prognosis. Nineteen patients with biopsy-confirmed subcutaneous sarcoidosis between 2009 and 2019 were selected. Mean age at diagnosis was 53 years. Lung involvement was detected in 10 patients (52.6%), mainly in stages I and II. Only two patients (10.5%) had additional systemic signs and five patients (26%) suffered from other autoimmune diseases simultaneously. Six patients (31.6%) had elevated angiotensin-converting enzyme levels (mean level 174.5 U/L). Eight patients (42%) received treatment, mainly systemic corticosteroids, and all patients except for one had a favorable clinical outcome. Subcutaneous sarcoidosis is frequently associated with a mild form of systemic disease, and the prognosis seems favorable regardless of treatment. Sarcoid nodules could be an early finding of systemic disease, allowing for less invasive procedures for histological confirmation.

Published
2021

50. Factors associated with negative 99mTc-MIBI scanning in patients with primary hyperparathyroidism

Author

C. Ayala, F. Carral, A.I. Jiménez, A. Díez, M. Tomé, J. Alvarez, and F. Partida

Subjects
medicine.medical_specialty, Multivariate analysis, endocrine system diseases, Adenoma, business.industry, General Engineering, Parathyroid hormone, Retrospective cohort study, Mean age, medicine.disease, Gastroenterology, Internal medicine, medicine, General Earth and Planetary Sciences, In patient, business, Primary hyperparathyroidism, General Environmental Science, Parathyroid adenoma
Abstract

Objective The objective was to evaluate the clinical and biological factors associated with negative 99mTc-MIBI scanning in patients with primary hyperparathyroidism (PHPT). Methods A retrospective observational study was designed in 195 patients (mean age: 59.2 ± 13.0 years; 77% woman) with PHPT (calcium: 11,3 ± 1,1 mg/dl and PTH: 218 ± 295 pg/ml) studied in endocrinology setting between 2013 and 2020. An univariate and multivariate analysis was made to evaluate the clinical and biological factors associated with negative 99mTc-MIBI scanning. Result 50 patients (26%) with negative 99mTc-MIBI scanning had lower PTH levels (146 ± 98 vs. 244 ± 334; p Conclusions One in four patients studied for PHPT had a negative 99mTc-MIBI scanning and were independent associated with size of adenoma ≤1 cm and upper adenoma localization.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results