1. Performance characteristics of an artificial intelligence based on convolutional neural network for screening conventional Papanicolaou-stained cervical smears
- Author
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Prosenjit Ganguli, Parikshit Sanyal, and Sanghita Barui
- Subjects
0301 basic medicine ,Cervical cancer ,Focus (geometry) ,business.industry ,030106 microbiology ,Papanicolaou stain ,Pattern recognition ,General Medicine ,medicine.disease ,Convolutional neural network ,Data set ,03 medical and health sciences ,0302 clinical medicine ,Cancer screening ,medicine ,False positive paradox ,Original Article ,030212 general & internal medicine ,Artificial intelligence ,Hyperchromasia ,business - Abstract
Background The conventional Papanicolaou-stained cervical smear is the most common screening test for cervical cancer. The sensitivity of the test in detecting abnormal cells is 67–75% in various studies. Owing to the volume of smears at cancer screening centres, significant man-hours are expended in the test. We have developed a software program for identification of foci of abnormal cells from conventional smears. We have chosen the convolutional neural network (CNN) model for its efficacy in image classification. Methods A total of 1838 microphotographs from cervical smears, containing 1301 ‘normal’ foci and 537 ‘abnormal’ foci were included in the study. The data set was split into training, testing and validation sets. A CNN was developed in the Python programming language. The CNN was trained with the training and testing set. At the end of training, 94.64% accuracy was achieved in the testing set. The CNN was then run on the validation set (441 images). Results The CNN showed 94.28% sensitivity, 96.01% specificity, 91.66% positive predictive value and 97.30% negative predictive value. The CNN could recognise normal squamous cells, overlapping cells, neutrophils and debris and classify the focus appropriately. False positives were reported when the CNN failed to recognise overlapping cells (2.7% microphotographs). It could correctly label cell clusters with high nuclear cytoplasmic ratio and hyperchromasia. In 1.8% of microphotographs, a false negative was reported. Conclusion The CNN showed 95.46% diagnostic accuracy, suggesting potential use in screening.
- Published
- 2020