1. The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective
- Author
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Nael Nadif Kasri, Dirk Schubert, Britt Mossink, and Moritz Negwer
- Subjects
Neurodevelopment ,Radial glia ,Review ,Biology ,Epigenesis, Genetic ,Histones ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Glutamatergic ,Transcriptional regulation ,0302 clinical medicine ,Intellectual disability ,medicine ,Animals ,Humans ,Epigenetics ,Molecular Biology ,030304 developmental biology ,Progenitor ,Neurons ,Pharmacology ,Chromatin accessibility ,0303 health sciences ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,DNA Helicases ,Neural progenitor ,Cell Biology ,Chromatin Assembly and Disassembly ,medicine.disease ,Chromatin ,Neurodevelopmental Disorders ,Molecular Medicine ,GABAergic ,Autism ,Protein Processing, Post-Translational ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Contains fulltext : 235071.pdf (Publisher’s version ) (Open Access) Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism spectrum disorders (ASD), are a large group of disorders in which early insults during brain development result in a wide and heterogeneous spectrum of clinical diagnoses. Mutations in genes coding for chromatin remodelers are overrepresented in NDD cohorts, pointing towards epigenetics as a convergent pathogenic pathway between these disorders. In this review we detail the role of NDD-associated chromatin remodelers during the developmental continuum of progenitor expansion, differentiation, cell-type specification, migration and maturation. We discuss how defects in chromatin remodelling during these early developmental time points compound over time and result in impaired brain circuit establishment. In particular, we focus on their role in the three largest cell populations: glutamatergic neurons, GABAergic neurons, and glia cells. An in-depth understanding of the spatiotemporal role of chromatin remodelers during neurodevelopment can contribute to the identification of molecular targets for treatment strategies.
- Published
- 2021