9 results on '"Emmanuel Dudoignon"'
Search Results
2. Early hypoalbuminemia is associated with 28-day mortality in severely burned patients: A retrospective cohort study
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Maurice Mimoun, Maïté Chaussard, Alexandre Fratani, Christian de Tymowski, Haikel Oueslati, Alexandru Cupaciu, James Anstey, Lucie Guillemet, Mourad Benyamina, Alexandre Mebazaa, Matthieu Legrand, Simon Pallado, Nabilla Moreno, Maxime Coutrot, Marion Jully, Sabri Soussi, M. Chaouat, Emmanuel Dudoignon, and François Dépret
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Burn Units ,Context (language use) ,Critical Care and Intensive Care Medicine ,Post injury ,Gastroenterology ,Capillary Permeability ,Cohort Studies ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Albumins ,Sepsis ,Internal medicine ,medicine ,Humans ,Severe burn ,Hypoalbuminemia ,Mortality ,Serum Albumin ,Aged ,Retrospective Studies ,Respiratory Distress Syndrome ,Trauma Severity Indices ,business.industry ,Albumin ,030208 emergency & critical care medicine ,Retrospective cohort study ,Crystalloid Solutions ,General Medicine ,Acute Kidney Injury ,Length of Stay ,Middle Aged ,Prognosis ,medicine.disease ,Respiration, Artificial ,Renal Replacement Therapy ,Emergency Medicine ,Fluid Therapy ,Female ,Surgery ,Burns ,28 day mortality ,Multiple organ dysfunction syndrome ,business - Abstract
Hypoalbuminemia is a frequent condition in the first 24 h after a severe burn injury and is associated with worse outcomes.We investigated the relation between very early hypoalbuminemia (6 h after admission) and clinical outcome in a retrospective cohort admitted to our unit for severe burn injuries between 2012 and 2017.73 severely burned patients were included, with a delay of admission of 3 (2-4) h. In a context of early exogenous supply of albumin, admission and 4H Albuminemia (Alb4 h) were significantly lower in deceased patients (respectively, 34 (29-37) vs 27 (23-30) g/l; p = 0.009 and 27 (24-32) vs 21 (17-27) g/l; p = 0.022) whereas albuminemia ≥6 h were not. The best threshold value of Alb4 h to discriminate 28-day mortality was 23 g/l. Patients with an Alb4 h 23 g/l had a higher 28-day mortality than patients with an Alb4 h ≥ 23 g/l (42% vs 11%; p = 0.003); adjusted OR = 4.47 (95% CI 1.15-17.36); p = 0.03.In severely burned patients receiving early albumin supply, early hypoalbuminemia is associated with higher mortality whereas later albuminemia (≥6 h) is not. Exploration of whether early albumin infusion (8-12 h post injury) may alter clinical outcome is warranted.
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- 2020
3. Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings?
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Emmanuel Dudoignon, François Dépret, and Matthieu Legrand
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medicine.medical_specialty ,030232 urology & nephrology ,Angiotensin-Converting Enzyme Inhibitors ,030204 cardiovascular system & hematology ,Kidney ,Renin-Angiotensin System ,Contractility ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Renin–angiotensin system ,Angiotensin-2 ,Renal fibrosis ,medicine ,Animals ,Humans ,Mineralocorticoid Receptor Antagonists ,business.industry ,Acute kidney injury ,Renal inflammation ,Acute Kidney Injury ,medicine.disease ,Fibrosis ,medicine.anatomical_structure ,Blood pressure ,Cardiology ,business - Abstract
The renin-angiotensin-aldosterone system (RAAS) plays a major role in the regulation of blood pressure, renal hemodynamic, myocardial contractility via an enzymatic cascade leading to the synthesis of angiotensin 2. The activation of the RAAS system after acute kidney injury triggers renal inflammation and fibrotic process with long-term damaging consequences. To date, there is still a debate on the benefits of RAAS for the kidney in acute settings. Effects of RAAS antagonists are variable in chronic or acute conditions. The aim of this review is to discuss the renal and systemic effects of the RAAS, and its modulation, in acute situations.
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- 2019
4. Outcome and potentially modifiable risk factors for candidemia in critically ill burns patients: A matched cohort study
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Blandine Denis, Marc Chaouat, Alexandre Alanio, Christian de Tymowski, Alexandru Cupaciu, David Boccara, François Dépret, Stéphane Bretagne, Haikel Oueslati, Maurice Mimoun, Axelle Ferry, Sabri Soussi, Matthieu Lafaurie, Maud Gits-Muselli, Emmanuel Dudoignon, Maxime Coutrot, Alexandre Fratani, James Anstey, Kevin Serror, Marion Jully, Matthieu Legrand, Maïté Chaussard, Mourad Benyamina, and Alexandre Mebazaa
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Adult ,Male ,0301 basic medicine ,Antifungal ,medicine.medical_specialty ,medicine.drug_class ,Critical Illness ,030106 microbiology ,Dermatology ,Sepsis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,fluids and secretions ,0302 clinical medicine ,Matched cohort ,Risk Factors ,hemic and lymphatic diseases ,Antibiotic therapy ,Internal medicine ,medicine ,Humans ,Aged ,Retrospective Studies ,Icu mortality ,Critically ill ,Septic shock ,business.industry ,Candidemia ,General Medicine ,Middle Aged ,equipment and supplies ,bacterial infections and mycoses ,medicine.disease ,Survival Analysis ,Drug Utilization ,Anti-Bacterial Agents ,Treatment Outcome ,Infectious Diseases ,Candida spp ,Female ,Burns ,business - Abstract
BACKGROUND Patients with extensive burns are at risk of developing candidemia. OBJECTIVES To identify potentially modifiable risk factors and outcomes of candidemia in critically ill burns patients. PATIENTS AND METHODS Retrospective matched cohort study including adult burns patients. Patients who developed candidemia were matched with burns patients with Candida spp colonisation and sepsis or septic shock without candidemia in a ratio of 1:3 (same severity scores and colonisation index). Univariate and multiple regression analyses were performed. RESULTS Of 130 severely burned patients with Candida spp colonisation and at least one episode of sepsis or septic shock, 14 were diagnosed with candidemia. In the candidemia group, patients had a median (IQR) total burns surface area (TBSA) of 57 (38-68)%, SAPSII of 43 (36-58) and ABSI of 11 (8-13). Multiple regression analysis showed that only duration of prior antibiotic therapy was independently associated with candidemia. ICU mortality was higher in the candidemia group (71% vs 35% [P = 0.02]). The log-rank test for 28-day mortality comparing patients with candidemia treated with an empirical strategy vs a curative strategy did not reach significance (P = 0.056). CONCLUSIONS Burns patients having received recent antibiotherapy have a higher risk of candidemia. Antifungal strategies did not influence outcome in this series.
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- 2018
5. Performance of a multiplex polymerase chain reaction panel for identifying bacterial pathogens causing pneumonia in critically ill patients with COVID-19
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Thibaut Poncin, Béatrice Berçot, Mourad Benyamina, Alexandre Mebazaa, François Caméléna, Jérôme Le Goff, Benoit Plaud, Emmanuel Dudoignon, Anne Clotilde Moy, Lucie Guillemet, Matthieu Lafaurie, Maxime Coutrot, Maïté Chaussard, Mélissa Budoo, François Dépret, Benjamin Deniau, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), CCSD, Accord Elsevier, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Université Sorbonne Paris Nord
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Male ,0301 basic medicine ,Microbiology (medical) ,Time Factors ,Microbiological culture ,Critical Illness ,[SDV]Life Sciences [q-bio] ,030106 microbiology ,medicine.disease_cause ,Sensitivity and Specificity ,Article ,Microbiology ,03 medical and health sciences ,0302 clinical medicine ,Multiplex polymerase chain reaction ,Pneumonia, Bacterial ,medicine ,Humans ,030212 general & internal medicine ,Pathogen ,Aged ,Bacteriological Techniques ,Bacteria ,medicine.diagnostic_test ,Pseudomonas aeruginosa ,business.industry ,SARS-CoV-2 ,Bacterial pneumonia ,COVID-19 ,General Medicine ,Rapid diagnostics ,Middle Aged ,medicine.disease ,3. Good health ,[SDV] Life Sciences [q-bio] ,Pneumonia ,Infectious Diseases ,Bronchoalveolar lavage ,Staphylococcus aureus ,Female ,business ,Bronchoalveolar Lavage Fluid ,Multiplex Polymerase Chain Reaction ,FilmArray Pneumonia Plus - Abstract
International audience; The FilmArray® Pneumonia Plus (FA-PP) panel can provide rapid identifications and semiquantitative results for many pathogens. We performed a prospective single-center study in 43 critically ill patients with coronavirus disease 2019 (COVID-19) in which we performed 96 FA-PP tests and cultures of blind bronchoalveolar lavage (BBAL). FA-PP detected 1 or more pathogens in 32% (31/96 of samples), whereas culture methods detected at least 1 pathogen in 35% (34/96 of samples). The most prevalent bacteria detected were Pseudomonas aeruginosa (n = 14) and Staphylococcus aureus (n = 11) on both FA-PP and culture. The FA-PP results from BBAL in critically ill patients with COVID-19 were consistent with bacterial culture findings for bacteria present in the FA-PP panel, showing sensitivity, specificity, and positive and negative predictive value of 95%, 99%, 82%, and 100%, respectively. Median turnaround time for FA-PP was 5.5 h, which was significantly shorter than for standard culture (26 h) and antimicrobial susceptibility testing results (57 h).
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- 2021
6. Ketamine-induced cholangiopathy in ARDS patients
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François Dépret, Matthieu Legrand, Christian de Tymowski, Vincent Mallet, and Emmanuel Dudoignon
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medicine.medical_specialty ,ARDS ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Pain medicine ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MEDLINE ,Critical Care and Intensive Care Medicine ,medicine.disease ,Anesthesiology ,Emergency medicine ,medicine ,Ketamine ,business ,medicine.drug - Published
- 2021
7. Intravenous ketamine and progressive cholangiopathy in COVID-19 patients
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Vincent Mallet, Kilian Bock, Paul Doumbe Mandengue, Nicolas Dufour, Torsten Voigtlaender, Jean-Damien Ricard, Pierre Isnard, Vincent Frochot, Emmanuel Letavernier, Lucile Moga, Amandine Landrieux, Pierre-Emmanuel Rautou, Nathalie Pons-Kerjean, Anaïs Vallet-Pichard, Laurent Chouchana, Coralie Gernez, Carole Burger, Anne Scemla, Christian de Tymoski, François Depret, Emmanuel Dudoignon, Lionel Lamhaut, Rémi Flicoteau, Géraldine Rousseau, Jean-Paul Duong Van Huyen, Jean-Michel Correas, Heiner Wedemeyer, and Stanislas Pol
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Male ,Cholangiopathy ,2019-20 coronavirus outbreak ,Intravenous ketamine ,Coronavirus disease 2019 (COVID-19) ,Cholangitis ,Biopsy ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Covid-19, Coronavirus infectious disease 2019 ,Bile Duct Diseases ,AST, aspartate aminotransferase ,UDCA, ursodeoxycholic acid ,End Stage Liver Disease ,ULN, upper limit of normal ,Liver Function Tests ,Cholestasis ,Germany ,ALT, alanine aminotransferase ,medicine ,Humans ,GGT, gamma-glutamyl transferase ,Ketamine ,Letter to the Editor ,Intrahepatic ,Anesthetics, Dissociative ,Duration of Therapy ,Dose-Response Relationship, Drug ,ALP, alkaline phosphatase ,Hepatology ,SARS-CoV-2 ,business.industry ,Middle Aged ,medicine.disease ,Respiration, Artificial ,Outcome and Process Assessment, Health Care ,Anesthesia ,Administration, Intravenous ,Female ,France ,Drug Monitoring ,Chemical and Drug Induced Liver Injury ,Covid-19 ,business ,MRI, magnetic resonance imaging ,medicine.drug - Published
- 2021
8. Three-month quality of life in survivors of ARDS due to COVID-19: a preliminary report from a French academic centre
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Emmanuel Dudoignon, Quentin Ressaire, Benoit Plaud, François Dépret, and Arnaud Valent
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medicine.medical_specialty ,2019-20 coronavirus outbreak ,ARDS ,post-intensive care syndrome ,Coronavirus disease 2019 (COVID-19) ,Critical Care and Intensive Care Medicine ,Quality of life (healthcare) ,Preliminary report ,Pandemic ,medicine ,Humans ,Survivors ,Letter to the Editor ,Fatigue ,Respiratory Distress Syndrome ,business.industry ,SARS-CoV-2 ,COVID-19 ,Retrospective cohort study ,General Medicine ,medicine.disease ,Post-intensive care syndrome ,Anesthesiology and Pain Medicine ,quality of life ,Emergency medicine ,business - Published
- 2020
9. Bacterial Pneumonia in COVID-19 Critically Ill Patients: A Case Series
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François Dépret, Emmanuel Dudoignon, Adrien Habay, Béatrice Berçot, Benjamin Deniau, Quentin Ressaire, Benoit Plaud, Maxime Coutrot, and François Caméléna
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Microbiology (medical) ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Critically ill ,business.industry ,Coinfection ,SARS-CoV-2 ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Critical Illness ,Bacterial pneumonia ,COVID-19 ,medicine.disease ,Coronavirus ,Pneumonia ,AcademicSubjects/MED00290 ,Infectious Diseases ,Anti-Infective Agents ,Correspondence ,Critical illness ,medicine ,Pneumonia, Bacterial ,Humans ,Intensive care medicine ,business - Published
- 2020
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