1. Metastases of soft tissue sarcoma to the liver: A Historical Cohort Study from a Hospital‐based Cancer Registry
- Author
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Toru Harabayashi, Masatake Matsuoka, Hiroaki Suzuki, Wataru Sakai, Toshiki Shinohara, Hiroyuki Kato, Ryuta Arai, Tamotsu Sagawa, Tamotsu Soma, Hidenori Kato, Masanori Okamoto, Hiroaki Hiraga, Noriaki Nishiyama, Toshikazu Nambu, and Hirohumi Adachi
- Subjects
0301 basic medicine ,Male ,Cancer Research ,Gastroenterology ,Cohort Studies ,neoplasm metastasis ,0302 clinical medicine ,Medicine ,Registries ,Child ,Original Research ,Aged, 80 and over ,Soft tissue sarcoma ,Soft tissue ,Sarcoma ,Hospital based ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Survival Rate ,Oncology ,030220 oncology & carcinogenesis ,Child, Preschool ,soft tissue sarcoma ,Female ,Leiomyosarcoma ,Adult ,Risk ,medicine.medical_specialty ,Stromal cell ,Adolescent ,retroperitoneal neoplasm ,lcsh:RC254-282 ,03 medical and health sciences ,Young Adult ,Internal medicine ,Confidence Intervals ,Humans ,Radiology, Nuclear Medicine and imaging ,Retroperitoneal Neoplasms ,Survival rate ,Aged ,liver neoplasms ,business.industry ,Infant ,Clinical Cancer Research ,leiomyosarcoma ,medicine.disease ,Retroperitoneal Neoplasm ,Cancer registry ,030104 developmental biology ,business - Abstract
Background: Hepatic metastasis of soft tissue sarcoma is rare compared to lung metastasis, and the literature is scarce. We examined the risk of hepatic metastasis according to the site of occurrence and histological type. Methods: From a Hospital-based Cancer Registry, 658 patients registered between 2007 and 2017 with soft tissue sarcomas were evaluated. The exclusion criteria were gastrointestinal stromal tumors, tumors of unknown origin, and follow-up periods of less than 1 month. SPSS 25 was used for statistical analysis. Results: The risk of hepatic metastasis was significantly higher in the retroperitoneum (HR, 5.981; 95% CI, 2.793-12.808) and leiomyosarcoma (HR, 4.303; 95% CI, 1.782-10.390). Multivariate analysis showed that the risk of hepatic metastasis as first distant metastasis was high in leiomyosarcoma (HR, 4.546; 95% CI, 2.275-9.086) and retroperitoneal onset (HR, 4.588; 95% CI, 2.280-9.231). The 2-year survival rate after hepatic metastasis was 21.7%. Conclusions: The onset of hepatic metastasis indicates a poor prognosis. However, hepatic metastasis from retroperitoneal sarcoma and leiomyosarcoma may be the first distant metastasis in some cases. For retroperitoneal sarcoma and leiomyosarcoma, additional screening for hepatic metastasis such as contrast CT should be considered during staging and follow-up after treatment., Article, Cancer medicine 17(17) : 6159-6165(2020)
- Published
- 2020