1. Role of endothelial cell specific molecule-1 (endocan) and cardiac imaging in early detection of cardiac involvement in psoriatic patients with or without arthritis
- Author
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Ahmed I. Eldesoky, Marwa Y. Soltan, Hala Abdulhady, Hala M.A. Sabah, Salwa M.A. Ibrahim, and Hebatallah A. Elshamy
- Subjects
Pathology ,medicine.medical_specialty ,Endothelial Cell-Specific Molecule 1 ,Tissue Doppler echocardiography ,business.industry ,Arthritis ,Early detection ,RC581-607 ,medicine.disease ,Rheumatology ,Psoriatic arthritis ,medicine ,Psoriasis ,Endocan ,Subclinical atherosclerosis ,Immunologic diseases. Allergy ,business ,Cardiac imaging - Abstract
Aim of the work: Measuring serum endocan level to determine its potential role in detecting subclinical cardiovascular involvement in psoriatic patients with or without arthritis. Patients and methods: This work included 14 psoriatic arthritis (PsA) patients, 14 psoriasis only (PsO) patients, and 14 age and sex matched controls. The psoriasis area severity index was evaluated. Serum endocan level was measured, subclinical atherosclerosis was assessed using brachial artery flow-mediated vasodilation (FMD), and echocardiography: standard and tissue Doppler imaging (TDI) was performed. Results: The mean age of PsA patients was 38.3 ± 9.9 years and for PsO was 37.9 ± 8 years. They were 3 males and 11 females in both groups with a comparable psoriasis duration (11 ± 4.9 vs 8 ± 6.3 years; p = 0.17). PsA patients had significantly increased endocan level (618 ± 227.8 ng/L) compared to those with PsO or controls (359 ± 185.7 and 130.6 ± 38.2 ng/L respectively; p
- Published
- 2022