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Background: The ThyPRO-39 questionnaire assesses health-related QoL (HRQoL) in patients with benign thyroid disease and has been validated for use in the local setting. The aim of the study is to investigate disease specific health-related quality of life using ThyPRO-39 in patients with newly diagnosed Graves’ disease treated with antithyroid medications over one year. Methods: Patients with newly diagnosed Graves’ disease were recruited in the outpatient setting. The ThyPRO-39 questionnaire was administered at baseline, 6 and 12 months of antithyroid medication treatment. Relevant demographic and clinical information was collected at the three time points of the study. Results of clinical parameters and various ThyPRO scales were compared between baseline, 6 months and 12 months of treatment. Results: There were 32 patients with newly diagnosed Graves’ disease recruited between April 2018 and May 2019. All except 2 patients completed all 3 time points of the study. Two patients missed their 6 months questionnaire. There were 24 females (75%) and 8 males (25%) in the study. Analysis of the clinical parameters showed significant changes in weight from baseline (59.7 + 17.7kg) to 6 months (59.4 + 9.9kg) to 12 months (63.4 + 17.4Kg), all p

A B S T R A C T Percutaneous fixation of pelvic and acetabular fractures are technically demanding procedures, and high rates of screw misplacement and potential neurovascular complications have been reported. One hundred and sixty two screws from a prospectively collected database were analysed to evaluate the accuracy of a fluoroscopically assisted computer navigated technique to insert a cannulated screw to treat pelvic and acetabular fractures. Actual screw position and trajectory with the intraoperative surgical plan stored in the navigation computer. The actual screw position differed from the surgical plan by a mean of 3.9 mm, with a mean 1.4 degree difference in screw trajectory. Post operative CT analysis of patients showed 10 screws perforated cortical bone. Our results show that the use of computer navigation can aid in the accurate placement of percutaneous screws along a predefined plan. It is still possible to incorrectly place a screw and great care needs to be taken with the surgical plan and also to understand the complex anatomy of the bony pelvis.