1. Detection Level of Salivary Survivin in Patients with OSCC
- Author
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Andrea Santarelli, Giuseppe Colella, Lo Muzio L, Maurizio Procaccini, Bambini F, G Giannatempo, Lo Russo L, Monica Emanuelli, and Marco Mascitti
- Subjects
Saliva ,medicine.medical_specialty ,Pathology ,business.industry ,Inhibitor of apoptosis ,Omics ,medicine.disease ,Gastroenterology ,Metastasis ,stomatognathic diseases ,Internal medicine ,Statistical significance ,Survivin ,medicine ,Biomarker (medicine) ,Stage (cooking) ,business - Abstract
Introduction: Survivin is a member of the Inhibitor of Apoptosis (IAP) proteins family, broadly expressed in most solid and haematological malignancies, but almost undetectable in normal adult tissues. Regarding Oral Squamous Cell Carcinoma (OSCC), Survivin expression seems to be correlated with aggressive phenotype and unfavorable outcome. In this work, the effectiveness of Survivin detection in saliva samples as diagnostic tool was investigated. Methods: 55 saliva samples from patients with histological diagnosis of OSCC and 30 samples from healthy controls matched for age and gender were collected. All samples from OSCC were collected before therapy. Saliva was analyzed using Assay Designs human Total Survivin TiterZyme® Enzyme Immunometric Assay (EIA) kit for Survivin detection and quantification. Survivin concentration (pg/ml) was studied in relationship to clinical data. Univariate statistical analysis was performed. Results: 35/55 (63.6%) among OSCC patients were found to be positive for surviving expression in saliva vs 12/30 (40%) among health controls; but the mean value was found to be higher in OSCC group (8,69 pg/ml ± 10,15 vs 2.44 pg/ml ± 4.22) reaching statistical significance (p
- Published
- 2013