1. The singular epidemiology of HPV infection among French Guianese women with normal cytology
- Author
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Vincent Lacoste, Jean Luc Deshayes, Fatiha Najioullah, Hatem Ben Amor, Paul Brousse, Maylis Douine, Vincent Molinie, Raymond Césaire, Odile Kilié, Nadia Thomas, Valentin Dufit, Gabriel Carles, Remy Pignoux, Dominique Catherine, Antoine Adenis, Claire Grenier, Mathieu Nacher, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Laboratoire de Virologie [Fort-de-France, Martinique], CHU de la Martinique [Fort de France], Service d'anatomopathologie [Fort de France, Martinique], CHU Fort de France, Service de Gynecologie Obstétrique [Cayenne], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Association de Dépistage Organisé des Cancers de Guyane (AGDOC), Département des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyane Française], Centre Hospitalier de l'Ouest Guyanais, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), The Study was funded by the European Regional Development Fund (FEDER) Presage number 30814., We wish to thank all study participants and the staff from the health centers of French Guiana., Lacoste, Vincent, Centre d'investigation clinique Antilles-Guyane ( CIC - Antilles Guyane ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU de la Martinique-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Laboratoire de Virologie-Immunologie [Fort de France, Martinique], Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Association guyanaise de dépistage organisé des cancers ( AGDOC ), Service de gynécologie-obstétrique [Saint Laurent du Maroni, Guyane Française], Réseau International des Instituts Pasteur ( RIIP ), and Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine ( COREVIH Guyane )
- Subjects
MESH: Cervix Uteri/cytology ,MESH: Uterine Cervical Neoplasms/pathology ,[SDV]Life Sciences [q-bio] ,MESH: Uterine Cervical Neoplasms/epidemiology ,Uterine Cervical Neoplasms ,Cervix Uteri ,0302 clinical medicine ,Informed consent ,Surveys and Questionnaires ,Epidemiology ,Prevalence ,MESH: DNA, Viral/genetics ,Medicine ,030212 general & internal medicine ,Papillomaviridae ,MESH: Aged ,MESH: Papillomavirus Infections/epidemiology ,Cervical cancer ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,MESH: Middle Aged ,Obstetrics ,lcsh:Public aspects of medicine ,HPV infection ,virus diseases ,[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH: Uterine Cervical Neoplasms/diagnosis ,Middle Aged ,female genital diseases and pregnancy complications ,3. Good health ,French Guiana ,[SDV] Life Sciences [q-bio] ,MESH: Papillomaviridae/genetics ,Women's Health Services ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,MESH: Papillomaviridae/isolation & purification ,MESH: Young Adult ,030220 oncology & carcinogenesis ,Female ,Normal cytology ,Research Article ,Papanicolaou Test ,Adult ,medicine.medical_specialty ,Human papillomavirus ,MESH: French Guiana/epidemiology ,Genotype ,MESH: Papillomavirus Infections/prevention & control ,MESH: Women's Health Services ,MESH: Papanicolaou Test ,Young Adult ,03 medical and health sciences ,MESH: Cross-Sectional Studies ,Humans ,MESH: Papillomaviridae/classification ,MESH: Surveys and Questionnaires ,MESH: Uterine Cervical Neoplasms/prevention & control ,[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology ,MESH: Prevalence ,MESH: Papillomavirus Infections/pathology ,Aged ,Gynecology ,MESH: Humans ,business.industry ,Public health ,Papillomavirus Infections ,Public Health, Environmental and Occupational Health ,Cancer ,MESH: Adult ,lcsh:RA1-1270 ,medicine.disease ,MESH: Papillomavirus Infections/diagnosis ,Cross-Sectional Studies ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Concomitant ,DNA, Viral ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Biostatistics ,business ,MESH: Female ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; BACKGROUND:In French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana.METHODS:Before the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear. Only women with normal cytology and a good quality smear were analyzed. The detection of HPV-DNA was performed using the GREINER-BIO-ONE kit.RESULTS:Overall, 27.2% of women with normal cervical cytology had a positive HPV-test. There was a U-shaped evolution of prevalence with women over 50 years having the highest HPV prevalence, followed by the 20 to 29 years group. The most prevalent HPV genotypes were HPV 53(3.52%), 68(3.33%), 52(2.59%), 31(2.22%) and 16 (1.85%). The proportion of HPV 16 among HPV-infected women was 6.8%.CONCLUSIONS:HPV prevalence in cytologically normal women was very high. The most prevalent genotypes were very different from what is usually described in the world, and notably in South America.
- Published
- 2017