21 results on '"Makoto Hayase"'
Search Results
2. Clinical Outcome of Patients With Large Vessel Occlusion and Low National Institutes of Health Stroke Scale Scores
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Takuya Saito, Ryo Itabashi, Yukako Yazawa, Kazutaka Uchida, Hiroshi Yamagami, Nobuyuki Sakai, Takeshi Morimoto, Shinichi Yoshimura, Ryosuke Doijiri, Yukiko Enomoto, Masayuki Ezura, Norihito Fukawa, Eisuke Furui, Akira Handa, Koichi Haraguchi, Taketo Hatano, Makoto Hayase, Nagayasu Hiyama, Koji Iihara, Norio Ikeda, Keisuke Imai, Hideyuki Ishihara, Yuki Kamiya, Chisaku Kanbayashi, Kazumi Kimura, Kazuo Kitagawa, Yoshihiro Kiura, Junya Kobayashi, Takao Kojima, Ryushi Kondo, Naoya Kuwayama, Yuji Matsumaru, Keigo Matsumoto, Yoshihisa Matsumoto, Kazuo Minematsu, Masafumi Morimoto, Kohei Nii, Kuniaki Ogasawara, Hiroyuki Ohnishi, Hajime Ohta, Takahiro Ohta, Yasushi Okada, Toshiyuki Onda, Manabu Sakaguchi, Shigeyuki Sakamoto, Makoto Sasaki, Junichiro Satomi, Masunari Shibata, Atsushi Shindo, Masataka Takeuchi, Norio Tanahashi, Naoki Toma, Kazunori Toyoda, Tomoyuki Tsumoto, Wataro Tsuruta, Naoyuki Uchiyama, Yoshiki Yagita, Taro Yamashita, Daisuke Yamamoto, Ikuya Yamaura, Takaaki Yamazaki, and Hiroaki Yasuda
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Male ,medicine.medical_specialty ,Multivariate analysis ,Brain Ischemia ,Modified Rankin Scale ,Internal medicine ,Post-hoc analysis ,medicine ,Humans ,Stroke ,Aged ,Advanced and Specialized Nursing ,Stroke scale ,business.industry ,Clinical Studies as Topic ,Endovascular Procedures ,Odds ratio ,Middle Aged ,medicine.disease ,United States ,Intracranial Embolism ,National Institutes of Health (U.S.) ,Tissue Plasminogen Activator ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Plasminogen activator ,Large vessel occlusion - Abstract
Background and Purpose— The treatment and prognosis of acute large vessel occlusion with mild symptoms have not been sufficiently studied. The present study aimed to investigate the clinical or radiological predictors of clinical outcome in patients with stroke with mild symptoms due to acute large vessel occlusion. Methods— Of 2420 patients with acute large vessel occlusion in the RESCUE-Japan Registry 2 (Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism-Japan Registry 2), a multicenter prospective registry in Japan, patients with modified Rankin Scale scores of 0 to 2 before onset and initial National Institutes of Health Stroke Scale (NIHSS) scores of 0 to 5 were examined in post hoc analysis. We examined the clinical and radiological characteristics associated with a favorable outcome (modified Rankin Scale score, 0–2 at 90 days) using multivariate analysis, as well as the factors associated with a favorable outcome in patients treated with endovascular therapy. Results— We analyzed 272 patients (median age, 73 years; median NIHSS score on admission, 3). Eighty-six (31.6%) patients were treated with intravenous recombinant tissue-type plasminogen activator, 54 (19.9%) underwent endovascular therapy, and 208 (76.5%) showed a favorable outcome. In multivariate analysis, age P Conclusions— Younger age, lower initial NIHSS score, intravenous recombinant tissue-type plasminogen activator, and absence of hyperglycemia were independently associated with a favorable outcome in patients with acute large vessel occlusion with low NIHSS scores. Registration— URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02419794.
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- 2020
3. Dissection of the Vertebral Artery Fenestration Limb Presenting with Occlusion After Rupture
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Tomoyuki Yamashita, Noritaka Sano, Ryotaro Otsuka, Hiroki Toda, Makoto Hayase, Hiroyuki Ikeda, Sadaharu Torikoshi, and Yoshitaka Tsujimoto
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medicine.medical_specialty ,Subarachnoid hemorrhage ,medicine.diagnostic_test ,business.industry ,Vertebral artery ,medicine.medical_treatment ,Blood flow ,Dissection (medical) ,medicine.disease ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine.artery ,Angiography ,Occlusion ,medicine ,Neurology (clinical) ,Embolization ,business ,Fenestration ,030217 neurology & neurosurgery - Abstract
Background Dissection of a vertebral artery (VA) fenestration is extremely rare. We herein present the first case of a patient who presented with the dissection of a VA fenestration limb accompanied by occlusion after rupture, who was treated with internal trapping of the dissected limb and the parent artery proximal to the fenestration. Case Description A 55-year-old man presented with sudden headache and altered consciousness. Computed tomography at admission showed subarachnoid hemorrhage. Angiography showed occlusion of the inner limb of the vertebrobasilar junction fenestration, and the occluded ends had a tapered shape, suggesting the occlusion of the dissection of the inner limb after rupture. Angiography immediately before embolization revealed inner limb recanalization with an irregular string sign; thus only the inner limb was embolized. Angiography after embolization showed near-complete suppression of the blood flow in the inner limb; however, a slight antegrade flow through the coil mass was observed in the late phase. The procedure was finished with the expectation of complete occlusion over time with natural heparin reversal. Angiography 8 days after embolization revealed a significant increase in antegrade blood flow through the coil mass within the inner limb. Therefore additional embolization of the parent artery proximal to the fenestration was performed, which achieved complete occlusion. Conclusions The embolization length was limited and the antegrade blood flow through the other limb remained during internal trapping for the dissected VA fenestration limb; therefore careful observation of the blood flow to the dissected segment after embolization is necessary.
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- 2020
4. A Patient with a Large Basilar Artery Aneurysm in Whom Coil Embolization Was Performed by Protruding an LVIS into the Aneurysmal Neck in a Barrel-like Shape and Preserving a Branch Vessel
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Noritaka Sano, Ryotaro Otsuka, Hiroki Toda, Sadaharu Torikoshi, Tomoyuki Yamashita, Makoto Hayase, and Hiroyuki Ikeda
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business.industry ,medicine.medical_treatment ,Barrel (horology) ,Stent ,Branch vessel ,Anatomy ,medicine.disease ,Aneurysm ,medicine.artery ,medicine ,Basilar artery ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Coil embolization - Published
- 2020
5. Blood Pressure Level and Variability During Long-Term Prasugrel or Clopidogrel Medication After Stroke: PRASTRO-I
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Kazunori Toyoda, Hiroshi Yamagami, Kazuo Kitagawa, Takanari Kitazono, Takehiko Nagao, Kazuo Minematsu, Shinichiro Uchiyama, Norio Tanahashi, Masayasu Matsumoto, Izumi Nagata, Masakatsu Nishikawa, Shinsuke Nanto, Toshiaki Shirai, Kenji Abe, Yasuo Ikeda, Akira Ogawa, Yukio Ozaki, Yoshinori Go, Hidefuku Gi, Eisuke Furui, Satoru Kosaka, Hiroshi Uenohara, Kozo Fukuyama, Chikashi Maruki, Katsunobu Takenaka, Tsuneaki Ogiichi, Kazushi Matsushima, Masato Osaki, Hidemitsu Nakagawa, Michio Aoki, Nobuyuki Sakai, Kazuhiko Kuroki, Takahisa Mori, Eiichi Uno, Tadashi Terasaki, Norifumi Metoki, Takashi Naka, Hideyuki Ohnishi, Hideki Koyama, Kotaro Ogihara, Hideki Kiriyama, Shuuichi Oki, Kei Murao, Masahiro Matsumoto, Kazunari Suzuki, Shinjiro Saito, Sumio Suda, Takashi Sadatomo, Hiroji Miyake, Kouji Itamoto, Keishi Fujita, Toshihiko Ohashi, Hiroki Ito, Yasuhiro Ito, Makoto Dehara, Tsutomu Hitotsumatsu, Makoto Hirose, Yusuke Nakagaki, Sunao Takemura, Hiroyuki Tomimitsu, Makoto Izuta, Susumu Mekaru, Shigenari Kin, Yuji Akaike, Masaki Miyatake, Naomichi Wada, Norio Shibata, Kazuo Koyama, Yasumitsu Ichikawa, Tsuyoshi Torii, Hiroshi Nakane, Yasushi Kobayashi, Shinya Kida, Shigeki Nishino, Hitoshi Tabata, Motoki Sano, Hiroto Fujigasaki, Kazuyuki Nagatsuka, Masatoshi Koga, Hitoshi Fujita, Masahiro Yasaka, Kimihiro Nakahara, Masahiko Tomiyama, Tsuneo Fujita, Seiichiro Hoshi, Takahiro Ota, Satoshi Orimo, Yoshio Momose, Katsuhiro Yamashita, Tatsuya Shingaki, Yasuhiko Kaku, Hideo Terasawa, Yukihiko Kawamoto, Yoshiharu Tokunaga, Kei Chiba, Yoshio Okada, Yoshimi Yanai, Atsushi Sato, Hirotomo Miake, Shu Imai, Masanori Morimoto, Mitsuru Nunomura, Shinsuke Irie, Shu Konno, Takao Kanzawa, Makoto Hayase, Kimihiro Yoshino, Tomohiko Izumidani, Masutaro Kanda, Shinichiro Kurokawa, Sanami Kawada, Keiichiro Takase, Hiroshi Takashima, Koichi Haraguchi, Hiroshi Murai, Mikio Suzuki, Mitsuteru Shimohata, Shigekazu Takeuchi, Ken Asakura, Tatsuya Seguchi, Yasuyuki Toba, Eishun Nitta, Akihito Moriki, Yoko Koan, Yoshiro Kaneko, Hisahiko Suzuki, Yasumasa Yoshida, Yutaka Naka, Shinji Katayama, Eiji Imamura, Kiyoshi Kazekawa, Iwae Yu, Akira Satoh, Junichi Maruyama, Akira Takahashi, Hirohiko Arimoto, Yasuhiro Hasegawa, Seiji Fukazawa, Yasuaki Nishimura, Tomonori Yamada, Tetsuro Tsuji, Akatsuki Wakayama, Kenichi Murao, Atsushi Tominaga, Hitonori Takaba, Mitsunori Shimazaki, Yasuhiro Ishibashi, Eiichi Oguni, Takayuki Kuroyanagi, Hirokazu Tanno, Norikazu Kawada, Hideki Hondo, Hideki Matsuoka, Toshitaka Umemura, Takanori Hazama, Masami Nishio, Tomoyuki Kawaba, Hirochiyo Wada, Ikuo Kamitsukasa, Sumio Endo, Toshihiro Ueda, Osamu Narumi, Tadashi Ino, Takeshi Yamada, Takao Urabe, Koichi Ota, Tokunori Kato, Kyoichi Nomura, Toshiaki Ieda, Masahiro Kagawa, Takamitsu Mizota, Kenji Sueyoshi, Yoshikazu Nakajima, Toshiaki Fujita, Yoshifumi Teramoto, Katsuharu Mori, Satoru Takaya, Kazuya Uemura, Akira Inukai, Michiya Kubo, Ryoichi Takahashi, Tsutomu Takahashi, Masamitsu Kawauchi, Kazuho Hirahara, Sadayuki Matsumoto, Osamu Masuo, Shinsuke Nishi, Jun Niwa, Naohiko Kubo, Kanji Yamamoto, Sadayoshi Watanabe, Satoshi Okuda, Kensho Okamoto, Atsuo Masago, Masafumi Ohuchi, Kunihiko Harada, Yoichiro Hashimoto, Kentaro Hayashi, Nobuya Fujita, Shuichi Mori, Manabu Sakaguchi, Kosumo Noda, Takeshi Aoki, Taizen Nakase, Satoshi Shibuya, Satoshi Kamei, Chisaku Kanbayashi, Naoyuki Hattori, Shutaro Takashima, Yasuhiro Manabe, Nobuaki Kobayashi, Katsunobu Takano, Minoru Ajiki, Yoshiyuki Kondo, Kazuo Hashikawa, Koji Ikezoe, Mitsuya Morita, Keiichi Sakai, Sono Toi, Makoto Iwamura, Juji Takeuchi, Toshihiko Suenaga, Masaki Takao, Takashi Kimura, Akihiko Ozaki, Tsutomu Kadekaru, Tsutomu Kato, Kosuke Yamashita, Tetsuro Ago, Shinichi Tamaru, Yoshiki Sekijima, Hisashi Ito, Masahiro Yamasaki, Hiromichi Kawai, Keisuke Imai, Tomoyuki Sekine, Hiroshi Inoya, Motoshi Sawada, Kazuo Mano, Masahiro Sonoo, and Masaki Ikeda
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Male ,medicine.medical_specialty ,Prasugrel ,Blood Pressure ,Double-Blind Method ,Recurrent stroke ,Internal medicine ,Thromboembolism ,Antithrombotic ,medicine ,Secondary Prevention ,Humans ,cardiovascular diseases ,Stroke ,Aged ,Ischemic Stroke ,Advanced and Specialized Nursing ,business.industry ,Blood pressure level ,Middle Aged ,medicine.disease ,Clopidogrel ,Blood pressure ,Ischemic stroke ,Hypertension ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Prasugrel Hydrochloride ,Platelet Aggregation Inhibitors ,medicine.drug - Abstract
Background and Purpose: High blood pressure increases bleeding risk during treatment with antithrombotic medication. The association between blood pressure levels and the risk of recurrent stroke during long-term secondary stroke prevention with thienopyridines (particularly prasugrel) has not been well studied. Methods: This was a post hoc analysis of the randomized, double-blind, multicenter PRASTRO-I trial (Comparison of Prasugrel and Clopidogrel in Japanese Patients With Ischemic Stroke-I). Patients with noncardioembolic stroke were randomly assigned (1:1) to receive prasugrel 3.75 mg/day or clopidogrel 75 mg/day for 96 to 104 weeks. Risks of any ischemic or hemorrhagic stroke, combined ischemic events, and combined bleeding events were determined based on the mean level and visit-to-visit variability, including successive variation, of systolic blood pressure (SBP) throughout the observational period. These risks were also compared between quartiles of mean SBP level and successive variation of SBP. Results: A total of 3747 patients (age 62.1±8.5 years, 797 women), with a median average SBP level during the observational period of 132.5 mm Hg, were studied. All the risks of any stroke (146 events; hazard ratio, 1.318 [95% CI, 1.094–1.583] per 10-mm Hg increase), ischemic stroke (133 events, 1.219 [1.010–1.466]), hemorrhagic stroke (13 events, 3.247 [1.660–6.296]), ischemic events (142 events, 1.219 [1.020–1.466]), and bleeding events (47 events, 1.629 [1.172–2.261]) correlated with increasing mean SBP overall. Similarly, an increased risk of these events correlated with increasing successive variation of SBP (hazard ratio, 3.078 [95% CI, 2.220–4.225] per 10-mm Hg increase; 3.051 [2.179–4.262]; 3.276 [1.172–9.092]; 2.865 [2.042–4.011]; 2.764 [1.524–5.016], respectively). Event rates did not differ between the clopidogrel and prasugrel groups within each quartile of SBP or successive variation of SBP. Conclusions: Both high mean SBP level and high visit-to-visit variability in SBP were significantly associated with the risk of recurrent stroke during long-term medication with either prasugrel or clopidogrel after stroke. Control of hypertension would be important regardless of the type of antiplatelet drugs. Registration: URL: https://www.clinicaltrials.jp ; Unique identifier: JapicCTI-111582.
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- 2021
6. Acute Thrombectomy for Cerebral Infarction: Comparative Study between Patients over 85 Years Old and Those below 85 Years Old
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Makoto Hayase, Akinori Miyakoshi, Kohichi Go, Yuki Oichi, Hiroki Toda, Noritaka Sano, and Takeshi Kawauchi
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medicine.medical_specialty ,Cerebral infarction ,business.industry ,030204 cardiovascular system & hematology ,medicine.disease ,Mechanical thrombectomy ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Acute cerebral infarction ,medicine ,Cardiology ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Acute ischemic stroke ,030217 neurology & neurosurgery - Published
- 2018
7. A peripartum major cerebral infarction in a patient with moyamoya disease following previous bilateral STA-MCA anastomosis: A case report
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Makoto Hayase, Masaki Nishimura, Yusuke Nakajima, Takahiro Kitahara, Tomoyuki Yamashita, Noritaka Sano, Sadaharu Torikoshi, and Ryota Motoie
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medicine.medical_specialty ,RD1-811 ,Anastomosis ,Magnetic resonance angiography ,Moyamoya disease ,Pregnancy ,medicine.artery ,Medicine ,Peripartum Period ,RC346-429 ,Stroke ,medicine.diagnostic_test ,business.industry ,Cerebral infarction ,medicine.disease ,Superficial temporal artery ,Surgery ,Middle cerebral artery ,Neurology. Diseases of the nervous system ,Neurology (clinical) ,business ,Delivery - Abstract
Background Although the incidence is rare, patients with moyamoya disease are at risk of stroke during pregnancy. Therefore, there is limited information regarding appropriate peripartum management. Herein, we report a case of major postpartum cerebral infarction in a patient with moyamoya disease, despite previous direct bilateral anastomosis of the superficial temporal artery to the middle cerebral artery (STA-MCA). Case description The patient was a 32-year-old woman who had undergone direct STA-MCA anastomosis and encephalo-myo-synangiosis in her childhood. This was her second pregnancy. She sustained a major ischemic stroke in the left middle cerebral artery area on postpartum day 3, which resulted in right hemiplegia and aphasia. On magnetic resonance angiography, simultaneous interruption of antegrade flow of the left middle cerebral artery and STA-MCA anastomosis was observed. The patency of these vessels was confirmed before the first pregnancy. The patient’s consciousness was impaired for several days due to edema in the infarct area. However, her condition improved following conservative treatment with osmotic diuretics and antiplatelet therapy; the patient recovered independent gait and her aphasia improved after 5 months of inpatient rehabilitation. Conclusions Careful monitoring of women with moyamoya disease is recommended during pregnancy and the peripartum period even if direct or indirect anastomosis has been previously performed.
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- 2021
8. Occipital Sinus Dural Arteriovenous Fistula Presenting with Cerebellar Hemorrhage
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Noritaka Sano, Yuki Oichi, Makoto Hayase, Akinori Miyakoshi, Hiroki Toda, Koichi Go, Hiroyuki Ikeda, and Takeshi Kawauchi
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medicine.medical_specialty ,Cerebellum ,Transvenous embolization ,Arteriovenous fistula ,Cranial Sinuses ,03 medical and health sciences ,0302 clinical medicine ,Occipital sinus ,Cerebellar Diseases ,medicine ,Humans ,Central Nervous System Vascular Malformations ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Embolization, Therapeutic ,Meningeal Arteries ,Shunt (medical) ,Cerebral Angiography ,medicine.anatomical_structure ,medicine.vein ,030220 oncology & carcinogenesis ,Cerebellar hemorrhage ,Angiography ,Surgery ,Female ,Neurology (clinical) ,Radiology ,Varices ,business ,Intracranial Hemorrhages ,030217 neurology & neurosurgery - Abstract
Background Occipital sinus (OS) dural arteriovenous fistula (DAVF) is extremely rare, and we are aware of no case accompanied by cerebral hemorrhage. We present a case of OS DAVF presenting with cerebellar hemorrhage, treated successfully by transvenous embolization. Case Description A 62-year-old female presented with headache and nausea of recent onset. Computed tomography revealed left cerebellar hemorrhage with perihematomal edema. Angiography showed OS DAVF fed by bilateral occipital and posterior meningeal arteries, with drainage into the left inferior hemispheric vein and right transverse sinus receiving the shunt flow from OS. The caudal side of the OS was occluded. The inferior hemispheric vein was dilated with 2 varices, and the junction between the OS and right transverse sinus was narrowed. Because the OS was not involved in normal cerebellar drainage, transvenous embolization of the OS was performed. The microcatheter was advanced to the OS from the transverse sinus during balloon occlusion at the confluence of sinuses. Coils were placed in the OS from the caudal to cranial side, and complete occlusion of the shunt was obtained. Conclusions This is the first report of OS DAVF presenting with cerebellar hemorrhage. Transvenous embolization of the affected OS appears ideal when transvenous access is feasible, and the OS is not involved in normal venous drainage of the cerebellum.
- Published
- 2019
9. Breakage and Retrieval of an Aspiration Catheter Coil with a Stent Retriever During Mechanical Thrombectomy
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Ryotaro Otsuka, Noritaka Sano, Yoshitaka Tsujimoto, Hiroyuki Ikeda, Makoto Hayase, Takeshi Kawauchi, Hiroki Toda, and Sadaharu Torikoshi
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Male ,medicine.medical_specialty ,Catheters ,medicine.medical_treatment ,Self Expandable Metallic Stents ,Infarction ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Occlusion ,medicine ,Humans ,cardiovascular diseases ,Common carotid artery ,Thrombus ,Device Removal ,Aged ,Thrombectomy ,business.industry ,Stent ,Cerebral Arteries ,equipment and supplies ,medicine.disease ,Surgery ,Prosthesis Failure ,Catheter ,030220 oncology & carcinogenesis ,Middle cerebral artery ,Neurology (clinical) ,Internal carotid artery ,business ,030217 neurology & neurosurgery - Abstract
Background Some mechanical thrombectomy techniques for acute ischemic stroke use a combination of an aspiration catheter and stent retriever. We experienced a rare case of aspiration catheter coil breakage and subsequent retrieval using a stent retriever. Case Description A 79-year-old man suddenly developed somnolence, global aphasia, and right hemiplegia. Magnetic resonance imaging revealed acute infarction of the left frontal lobe and occlusion of the left common carotid artery. Thus, using an aspiration catheter and a stent retriever, mechanical thrombectomy was performed. The stent retriever was deployed from the middle cerebral artery to the internal carotid artery and retracted into the aspiration catheter placed in the internal carotid artery proximal to the thrombus. The catheter was bent during retraction of the stent retriever. After thrombus aspiration, the internal carotid and anterior and middle cerebral arteries were successfully reperfused; however, the stent retriever captured a broken section of the winding coil of the aspiration catheter. We suspected that an X-ray marker on the stent retriever broke the winding coil at the bent segment of the aspiration catheter and the stent captured the broken coil. Conclusions The combined use of an aspiration catheter and a stent retriever may cause unexpected device breakage, especially when the catheter is bent.
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- 2019
10. Endovascular Therapy in Ischemic Stroke With Acute Large-Vessel Occlusion: Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism Japan Registry 2
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Ikuya Yamaura, Masafumi Morimoto, Ryo Itabashi, Junya Kobayashi, Kazutaka Uchida, Tomoyuki Tsumoto, Chisaku Kanbayashi, Yoshihisa Matsumoto, Koichi Haraguchi, Naoyuki Uchiyama, Naoya Kuwayama, Naoto Kimura, Eisuke Furui, Masataka Takeuchi, Takahiro Ohta, Yoshiki Yagita, Yasushi Okada, Takao Kojima, Masayuki Ezura, Manabu Sakaguchi, Nobuyuki Sakai, Kuniaki Ogasawara, Hiroaki Yasuda, Shigeyuki Sakamoto, Taro Yamashita, Kazuo Minematsu, Keigo Matsumoto, Atsushi Shindo, Hideyuki Ishihara, Kazunori Toyoda, Makoto Sasaki, Ryosuke Doijiri, Wataro Tsuruta, Norihito Fukawa, Kouhei Nii, Yoshihiro Kiura, Keisuke Imai, Hajime Ohta, Hiroyuki Ohnishi, Takaaki Yamazaki, Ryushi Kondo, Kazuo Kitagawa, Taketo Hatano, Hiroshi Yamagami, Norio Ikeda, Yuki Kamiya, Nagayasu Hiyama, Junichiro Satomi, Yuji Matsumaru, Akira Handa, Koji Iihara, Takeshi Morimoto, Makoto Hayase, Daisuke Yamamoto, Naoki Toma, Masunari Shibata, Norio Tanahashi, Shinichi Yoshimura, Yukiko Enomoto, Toshiyuki Onda, and Kazumi Kimura
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Male ,Time Factors ,030204 cardiovascular system & hematology ,registry ,Brain Ischemia ,Disability Evaluation ,0302 clinical medicine ,Japan ,Risk Factors ,Occlusion ,Prospective Studies ,Registries ,Stroke ,Thrombectomy ,Original Research ,Aged, 80 and over ,Quality and Outcomes ,Fibrinolysis ,Endovascular Procedures ,Middle Aged ,Treatment Outcome ,Intracranial Embolism ,Cardiology ,Female ,Stents ,Cardiology and Cardiovascular Medicine ,Adult ,medicine.medical_specialty ,Endovascular therapy ,Cerebrovascular Procedures ,03 medical and health sciences ,Young Adult ,Text mining ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,propensity score ,Aged ,Ischemic Stroke ,endovascular therapy ,business.industry ,large‐vessel occlusion ,Recovery of Function ,medicine.disease ,Embolism ,Propensity score matching ,Ischemic stroke ,Cerebrovascular Disease/Stroke ,business ,030217 neurology & neurosurgery ,Angioplasty, Balloon ,Large vessel occlusion - Abstract
Background Endovascular therapy has been shown to be effective in patients with acute cerebral large‐vessel occlusion, but real‐world efficacies are unknown. Methods and Results We conducted a prospective registry at 46 centers between October 2014 and January 2017. Eligible patients were those who were aged 20 years or older, with acute cerebral large‐vessel occlusion, and who were hospitalized within 24 hours of the onset. We enrolled both consecutive patients who were treated with or without endovascular therapy. Endovascular therapy included thrombectomy, balloon angioplasty, stenting, local fibrinolysis, and piercing. The primary outcome was a favorable outcome as defined by a modified Rankin Scale of 0 to 2 at 90 days after onset. Secondary outcomes were modified Rankin Scale of 0 to 1 and mortality. Safety outcomes were intracerebral hemorrhage or a recurrence of ischemic stroke. We constructed the 2242 (1121 each) propensity score–matched patients cohort based on a propensity score for endovascular therapy and estimated the adjusted odds ratio, followed by sensitivity analyses on original 2399 (1278 in endovascular therapy versus 1121 in no endovascular therapy) patients. In the propensity score–matched cohort, favorable outcomes were observed in 35.3% and 30.7% of patients in the endovascular therapy and no endovascular therapy groups, respectively ( P= 0.02). The adjusted odds ratio for the favorable outcome was 1.44 (95% confidence interval, 1.10–1.86, P =0.007). The efficacy of endovascular therapy in achieving favorable outcomes did not differ between our subgroups and in the sensitivity analyses. Conclusions Endovascular therapy decreased disabilities at 90 days in real‐world patients with acute cerebral large‐vessel occlusion. Clinical Trial Registration URL: http://www.clinicaltrials.gov . Unique identifier: NCT02419794.
- Published
- 2018
11. International multicentre validation of the arteriovenous malformation-related intracerebral haemorrhage (AVICH) score
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Dino Podlesek, Volker Seifert, Marian Christoph Neidert, Christopher S. Ogilvy, Gabriele Schackert, Makoto Hayase, Luca Regli, Burkhardt Seifert, Jan-Karl Burkhardt, John D. Nerva, Juergen Konczalla, Nazife Dinc, Oliver Bozinov, Andreas Kneist, Thomas Wanet, Kaoru Kurisu, Fusao Ikawa, Michael T. Lawton, Ulrich Sure, Christoph J. Griessenauer, Sven Gläsker, Julian Habdank-Kolaczkowski, Louis J. Kim, Taketo Hatano, University of Zurich, Burkhardt, Jan-Karl, Faculty of Medicine and Pharmacy, Neurosurgery, and Surgical clinical sciences
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Adult ,Intracranial Arteriovenous Malformations ,Male ,medicine.medical_specialty ,Adolescent ,Clinical Neurology ,Medizin ,610 Medicine & health ,Severity of Illness Index ,cerebrovascular ,2738 Psychiatry and Mental Health ,Young Adult ,03 medical and health sciences ,Ich score ,0302 clinical medicine ,Internal medicine ,Statistics ,medicine ,Humans ,Trial registration ,Cerebral Hemorrhage ,Retrospective Studies ,Univariate analysis ,business.industry ,Modified rankin score ,External validation ,Univariate ,Arteriovenous malformation ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,Middle Aged ,Prognosis ,medicine.disease ,2746 Surgery ,Psychiatry and Mental health ,2728 Neurology (clinical) ,030220 oncology & carcinogenesis ,Female ,Surgery ,Neurology (clinical) ,Outcome prediction ,business ,030217 neurology & neurosurgery - Abstract
ObjectiveThe recently published arteriovenous malformation-related intracerebral haemorrhage (AVICH) score showed better outcome prediction for patients with arteriovenous malformation (AVM)-related intracerebral haemorrhage (ICH) than other AVM or ICH scores. Here we present the results of a multicentre, external validation of the AVICH score.MethodsAll participating centres (n=11) provided anonymous data on 325 patients to form the Spetzler-Martin (SM) grade, the supplemented SM (sSM) grade, the ICH score and the AVICH score. Modified Rankin score (mRS) at last follow-up (mean 25.6 months) was dichotomized into favourable (mRS 0-2, n=210) and unfavourable (mRS 3-6;n=115). Univariate and AUROC analyses were performed to validate the AVICH score.ResultsExcept nidus structure and AVM size, all single parameters forming the SM, sSM, ICH and AVICH score and the scores itself were significantly different between both outcome groups in the univariate analysis. The AVICH score was confirmed to be the highest predictive outcome score with an AUROC of 0.765 compared with 0.705 for the ICH score and 0.682 for the sSM grade.ConclusionThe multicentre-validated AVICH score predicts clinical outcome superior to pre-existing scores. We suggest the routine use of this score for future clinical outcome prediction and in clinical research.Trial registration numberNCT02920645.
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- 2018
12. Myeloperoxidase Propagates Damage and is a Potential Therapeutic Target for Subacute Stroke
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Reza Forghani, Yi Zheng, John W. Chen, Lionel Bure, Hyeon Ju Kim, Ying Wei, Gregory R. Wojtkiewicz, Michael A. Moskowitz, Yue Wu, and Makoto Hayase
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medicine.medical_specialty ,Subacute stroke ,Ischemia ,Inflammation ,Pharmacology ,Mice ,Oxidative enzyme ,medicine ,Animals ,Enzyme Inhibitors ,Stroke ,Peroxidase ,Mice, Knockout ,biology ,medicine.diagnostic_test ,business.industry ,Brain ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Enzyme assay ,Surgery ,Mice, Inbred C57BL ,Disease Models, Animal ,Neurology ,Myeloperoxidase ,biology.protein ,Original Article ,Neurology (clinical) ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Few effective treatment options exist for stroke beyond the hyperacute period. Radical generation and myeloperoxidase (MPO) have been implicated in stroke. We investigated whether pharmacologic reduction or gene deletion of this highly oxidative enzyme reduces infarct propagation and improves outcome in the transient middle cerebral artery occlusion mouse model (MCAO). Mice were treated with 4-aminobenzoic acid hydrazide (ABAH), a specific irreversible MPO inhibitor. Three treatment regimens were used: (1) daily throughout the 21-day observational period, (2) during the acute stage (first 24 hours), or (3) during the subacute stage (daily starting on day 2). We found elevated MPO activity in ipsilateral brain 3 to 21 days after ischemia. 4-Aminobenzoic acid hydrazide reduced enzyme activity by 30% to 40% and final lesion volume by 60% ( P
- Published
- 2015
13. Two cases of symptomatic contrast-induced encephalopathy after coil embolization of unruptured cerebral aneurysm
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Akinori Miyakoshi, Taketo Hatano, Junya Taki, Takehiko Nakamura, Toshinari Kawasaki, and Makoto Hayase
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medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Encephalopathy ,medicine.disease ,medicine ,Unruptured cerebral aneurysm ,Contrast (vision) ,Neurology (clinical) ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,media_common ,Coil embolization - Published
- 2015
14. Carotid Artery Stenting for Bilateral Cerebral Malperfusion due to Carotid Dissection after Open Surgical Repair of Type A Aortic Dissection in Marfan Syndrome : A Case Report
- Author
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Makoto Hayase, Tao Yang, Masashi Oda, Takehiko Nakamura, and Taketo Hatano
- Subjects
Marfan syndrome ,Carotid artery dissection ,medicine.medical_specialty ,business.industry ,medicine ,Surgery ,Neurology (clinical) ,medicine.disease ,business - Published
- 2015
15. Anticoagulant therapy for recurrent in-stent thrombosis following carotid artery stenting: A case report
- Author
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Akinori Miyakoshi, Makoto Hayase, Etsuko Hattori, Takeshi Kawauchi, Yuki Oichi, and Hiroki Toda
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Argatroban ,Magnetic resonance angiography ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Internal medicine ,Coronary stent ,medicine ,Humans ,cardiovascular diseases ,Carotid Artery Thrombosis ,Thrombus ,Ultrasonography, Doppler, Color ,Aged, 80 and over ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,business.industry ,Stent ,Anticoagulants ,medicine.disease ,Clopidogrel ,Thrombosis ,Surgery ,Stroke ,Diffusion Magnetic Resonance Imaging ,Cardiology ,Stents ,business ,030217 neurology & neurosurgery ,Angioplasty, Balloon ,Magnetic Resonance Angiography ,medicine.drug - Abstract
We report a case in which strict anticoagulant therapy management was useful for a recurrent in-stent thrombosis after carotid artery stenting (CAS). An 84-year-old man presented with cognitive decline that progressed rapidly over two months. Head magnetic resonance imaging showed an acute-stage infarct occurring frequently in the right cerebral hemisphere, and he underwent hospitalization and treatment. On neck magnetic resonance angiography (MRA), severe stenosis was found at the origin of the right internal carotid artery. Since he took aspirin, clopidogrel, and a statin after placement of an indwelling coronary stent, we treated him by adding argatroban and edaravone drip therapy to his existing medication. CAS was performed on day 15 of the hospitalization. A small in-stent thrombosis with plaque protrusion was observed on a carotid sonogram performed at the second day after CAS, and re-examination at the seventh day confirmed enlargement of the lesion and an increase in peak systolic velocity; thus, a second CAS procedure was performed on the same day. After the second CAS, oral cilostazol was added for triple antiplatelet therapy (TAPT), but as the in-stent thrombosis increased further, we started a continuous infusion of heparin with the goal of an activated partial thromboplastin time (APTT) of 50 to 65 seconds. After starting heparin, the lesion did not progress; after 14 days of continuous heparin infusion, the patient was switched to TAPT, and regression of the plaque was confirmed. This case demonstrated to us that controlled anticoagulation therapy can be an effective treatment for cases in which a thrombus recurs within a stent after CAS.
- Published
- 2017
16. Jailed double-microcatheter technique following horizontal stenting for coil embolization of intracranial wide-necked bifurcation aneurysms: A technical report of two cases
- Author
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Makoto Hayase, Akinori Miyakoshi, Etsuko Hattori, Takehiko Nakamura, Takahiro Kitahara, and Taketo Hatano
- Subjects
medicine.medical_specialty ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Aneurysm ,medicine.artery ,medicine ,Basilar artery ,Initial treatment ,Humans ,cardiovascular diseases ,Endovascular treatment ,Coil embolization ,business.industry ,Endovascular Procedures ,Intracranial Aneurysm ,Middle Aged ,medicine.disease ,Embolization, Therapeutic ,Blood Vessel Prosthesis ,Surgery ,Wide necked aneurysm ,Basilar Artery ,cardiovascular system ,Female ,Stents ,Radiology ,Internal carotid artery ,business ,030217 neurology & neurosurgery ,Carotid Artery, Internal - Abstract
The horizontal stenting technique facilitates endovascular treatment of wide-necked bifurcation intracranial aneurysms. Previous literature shows, however, that subsequent coil embolization at initial treatment results in incomplete obliteration in many cases. The authors present two consecutive cases of wide-necked large bifurcation aneurysms to describe an additional coil embolization technique following horizontal stenting. The patients were a 53-year-old female with an unruptured internal carotid artery terminus aneurysm and a 57-year-old female with a recurrent basilar artery tip aneurysm. Both patients underwent endovascular treatment with horizontal stenting followed by coil embolization with jailed double-microcatheters. Immediate complete obliteration was achieved with no complications, and no recanalization was observed at the one-year follow-up in both cases. Coil embolization with jailed double-microcatheter technique following horizontal stenting is a safe and effective strategy for wide-necked bifurcation aneurysms.
- Published
- 2017
17. Surgical Interposition of a Cervical Carotid Artery Pseudoaneurysm caused by Central Venous Catheterization using a Synthetic Graft : A Case Report
- Author
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Yukinori Terada, Makoto Hayase, Masashi Oda, Taketo Hatano, and Takehiko Nakamura
- Subjects
medicine.medical_specialty ,Pseudoaneurysm ,Venous catheterization ,business.industry ,Carotid arteries ,medicine ,Surgery ,Synthetic graft ,Neurology (clinical) ,medicine.disease ,business ,Carotid artery aneurysm - Published
- 2013
18. Transplantation of telencephalic neural progenitors induced from embryonic stem cells into subacute phase of focal cerebral ischemia
- Author
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Kazuhiko Nozaki, Takeshi Marumo, Hiroharu Kataoka, Masanori Gomi, Masaki Nishimura, Makoto Hayase, Hideki Hayashi, Susumu Miyamoto, Nobuo Hashimoto, Motoaki Fujimoto, Yasushi Takagi, and Jun Takahashi
- Subjects
Pathology ,medicine.medical_specialty ,Cellular differentiation ,Central nervous system ,Cell Culture Techniques ,Ischemia ,Biology ,Basal Ganglia ,Culture Media, Serum-Free ,Brain Ischemia ,Cell Line ,Pathology and Forensic Medicine ,Cell therapy ,Mice ,SOX1 ,Neural Stem Cells ,medicine ,Animals ,Progenitor cell ,Molecular Biology ,Embryonic Stem Cells ,Neurologic Examination ,Brain Neoplasms ,SOXB1 Transcription Factors ,Teratoma ,Cell Differentiation ,Cell Biology ,Flow Cytometry ,medicine.disease ,Embryonic stem cell ,Cell biology ,Transplantation ,medicine.anatomical_structure - Abstract
Cerebral ischemia causes neuronal death and disruption of neural circuits in the central nervous system. Various neurological disorders caused by cerebral infarction can severely impair quality of life and are potentially fatal. Functional recovery in the chronic stage mainly depends on physical treatment and rehabilitation. We aim to establish cell therapy for cerebral ischemia using embryonic stem (ES) cells, which have self-renewing and pluripotent capacities. We previously reported that the transplanted monkey and mouse ES cell-derived neural progenitors, by stromal cell-derived inducing activity method, could survive and differentiate into various types of neurons and glial cells, and form the neuronal network in basal ganglia. In this report, we induced the differentiation of the neural progenitors from mouse ES cells using the serum-free suspension culture method and confirmed the expression of various basal ganglial neuronal markers and neurotransmitter-related markers both in vitro and in vivo, which was thought to be suitable for replacing damaged striatum after middle cerebral artery occlusion. This is the first report that used selectively induced telencephalic neural progenitors into ischemia model. Furthermore, we purified the progenitors expressing the neural progenitor marker Sox1 by fluorescence-activated cell sorting and Sox1-positive neural progenitors prevented tumor formation in ischemic brain for 2 months. We also analyzed survival and differentiation of transplanted cells and functional recovery from ischemic damage.
- Published
- 2012
19. Tissue Inhibitor of Metalloproteinases Protect Blood—Brain Barrier Disruption in Focal Cerebral Ischemia
- Author
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Motoaki Fujimoto, Hiroharu Kataoka, Yasushi Takagi, Makoto Hayase, Kazuhiko Nozaki, Masanori Gomi, Tomohiro Aoki, Takeshi Marumo, Masaki Nishimura, and Nobuo Hashimoto
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Ischemia ,Apoptosis ,Endogeny ,Matrix metalloproteinase ,Blood–brain barrier ,Neuroprotection ,Brain Ischemia ,Tight Junctions ,Brain ischemia ,Mice ,chemistry.chemical_compound ,Internal medicine ,Edema ,medicine ,Animals ,RNA, Messenger ,Evans Blue ,Mice, Knockout ,Neurons ,Tissue Inhibitor of Metalloproteinase-2 ,Tissue Inhibitor of Metalloproteinase-1 ,Caspase 3 ,business.industry ,Brain ,medicine.disease ,Mice, Inbred C57BL ,medicine.anatomical_structure ,Endocrinology ,Matrix Metalloproteinase 9 ,Neurology ,chemistry ,Blood-Brain Barrier ,Matrix Metalloproteinase 2 ,Neurology (clinical) ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Enhanced matrix metalloproteinases (MMPs) can cause vasogenic edema and hemorrhagic transformation after cerebral ischemia, and affect the extent of ischemic injury. We hypothesized that the endogenous MMP inhibitors, tissue inhibitor of MMPs (TIMPs), were essential to protect against blood—brain barrier (BBB) disruption after ischemia by regulating the activities of MMPs. We confirmed the transition of MMP-2 and MMP-9, and the TIMPs family after 30 mins of middle cerebral artery occlusion, and elucidated the function of TIMP-1 and TIMP-2 in focal ischemia, using TIMP-1−/−and TIMP-2−/− mice. TIMP-1 mRNA expression was gradually increased until 24 h after reperfusion. In TIMP-1−/− mice, MMP-9 protein expression and gelatinolytic activity were significantly more augmented after cerebral ischemia than those in WT mice, and were accompanied by exacerbated BBB disruption, neuronal apoptosis, and ischemic injury. In contrast, TIMP-2 gene deletion mice exhibited no significant difference in MMP expressions and the degree of ischemic injury despite an increased Evans blue leakage. These results suggest that TIMP-1 inhibits MMP-9 activity and can play a neuroprotective role in cerebral ischemia.
- Published
- 2008
20. Intraprocedural detection of cerebral hyperperfusion by flat detector computed tomography in the evaluation of cerebral blood volume during carotid artery stenting. A case report
- Author
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Makoto Hayase, Yukinori Terada, Masashi Oda, Yasunori Nagai, Taketo Hatano, and Takehiko Nakamura
- Subjects
Male ,medicine.medical_specialty ,Subarachnoid hemorrhage ,Hemodynamics ,Blood volume ,Lateralization of brain function ,medicine ,Humans ,Carotid Stenosis ,Aged, 80 and over ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,Blood Volume Determination ,business.industry ,Endovascular Procedures ,Original Articles ,Sulcus ,medicine.disease ,Cerebral Angiography ,medicine.anatomical_structure ,Cerebral blood volume ,Blood pressure ,Diffusion Magnetic Resonance Imaging ,Stents ,Radiology ,business ,Tomography, X-Ray Computed ,Cerebral angiography - Abstract
Cerebral blood volume (CBV) can be measured using a C-arm flat detector angiographic system. The present report describes a case in which cerebral hyperperfusion was detected with the Neuro parenchymal blood volume (PBV) system (syngo Neuro PBV IR, Siemens Medical Solutions, Erlangen, Germany) during carotid artery stenting (CAS). An 89-year-old man was referred to our hospital for cerebral brain infarction and severe stenosis of the left carotid artery. CAS was performed, and Neuro PBV was used to measure CBV both during and after the procedure. Postoperative Neuro PBV revealed dramatically increased CBV, and a hyperperfusion state was suspected. The next day, subarachnoid hemorrhage along the sulcus of the left hemisphere was revealed on computed tomography. Strict management of blood pressure was instituted just after the detection of hyperperfusion, and the patient was ultimately discharged from the hospital without any new neurological deficits. Neuro PBV has the advantage that it can be performed in the angiography suite and does not require patient transfer to an alternate setting. Therefore, intracranial hemodynamic changes can be detected during the procedure. We conclude that the Neuro PBV system is useful for monitoring intracranial hemodynamics during endovascular procedures.
- Published
- 2013
21. The Role of Ly6C+ Inflammatory Spleen-derived Monocytes in an Animal Model of Brain Ischemia
- Author
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Oleg Butovsky, Makoto Hayase, Laurel Yong-Hwa Lee, Howard L. Weiner, Ying Wei, Michael A. Moskowitz, and Christian Waeber
- Subjects
Brain ischemia ,Pathology ,medicine.medical_specialty ,Animal model ,medicine.anatomical_structure ,business.industry ,Immunology ,medicine ,Immunology and Allergy ,Spleen ,business ,medicine.disease - Published
- 2010
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