1. Aortic valve repair for insufficiency in older children offers unpredictable durability that may not be advantageous over a primary Ross operation
- Author
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Mohammed Al Jughiman, Christopher A. Caldarone, Michael Gritti, Glen S. Van Arsdell, Edward J. Hickey, E. Pham-Hung, and Travis J. Wilder
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Reoperation ,Pulmonary and Respiratory Medicine ,Aortic valve ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Aortic Valve Insufficiency ,030204 cardiovascular system & hematology ,Prosthesis ,03 medical and health sciences ,0302 clinical medicine ,Aortic valve repair ,Aortic valve replacement ,Internal medicine ,medicine ,Humans ,Cardiac Surgical Procedures ,Child ,Retrospective Studies ,Heart Valve Prosthesis Implantation ,Analysis of Variance ,Univariate analysis ,business.industry ,Ross procedure ,Infant ,Repeated measures design ,General Medicine ,medicine.disease ,Surgery ,Stenosis ,medicine.anatomical_structure ,030228 respiratory system ,Aortic Valve ,Child, Preschool ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objectives To evaluate the durability of aortic valve (AoV) repair relative to other strategies for children with significant aortic insufficiency (AI). Methods From 2001 to 2012, 90 children with greater than or equal to moderate AI underwent surgery. Resulting procedures were classified according to final operative outcome: AoV repair (repair; n = 46, 51%), Ross procedure (Ross; n = 21, 23%) or replacement with mechanical or tissue prosthesis [aortic valve replacement (AVR); n = 23, 26%]. Repeated measures (n = 1081 echocardiograms) mixed-model analysis and parametric multiphase risk-adjusted hazard analysis were used to evaluate haemodynamic parameters and durability of operations. Results Mean age at operation was similar for repair and Ross groups, but slightly higher for the AVR group (10.6, 11 and 13.2, respectively; P = 0.04). Baseline annular dimensions were similar among groups. Of 46 repairs, 85% involved pericardial leaflet extensions (commonly with leaflet shaving and/or commisuroplasty). The remaining repairs were commissuroplasties. On multivariable analysis, repair was associated with increased early (∼1-2 years) AI and increased outflow tract peak pressure gradients relative to Ross and AVR procedures. On univariate analysis, repairs tended to have a larger annulus size compared with Ross or AVR; however, this was not significant on multivariable analysis. There were 25 reinterventions (surgical reoperation = 16; transcatheter intervention = 9) for 22 children. Freedom from surgical reoperation was 64, 100 and 51% at 6 years for repairs, Ross and AVR, respectively (P = 0.05); however, three of five reoperations after AVR were for failed bioprosthetic devices. The freedom from reintervention was not significantly influenced by the type of AoV operation (P = 0.43). Conclusions Durability of aortic valve repair for children is limited by recurrence of AI and/or stenosis, often within the first few years. After repair, reoperation should be anticipated within ∼7 years.
- Published
- 2015
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