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Alveolar soft part sarcoma (ASPS) is a rare malignant neoplasm that tends to occur in the deep soft tissues of both adults and children. ASPS has a progressive clinical course that is unfortunately characterised by late metastases and an overall poor prognosis. Although the tumour has been reported in a wide range of anatomic sites, few cases of primary laryngeal ASPS are reported in the literature. Here, we report the case of a 24-year-old man with no significant medical history who presented with progressive mild dysphonia and hoarseness. Imaging studies revealed a well-circumscribed, partially cystic submucosal mass with involvement of the right vocal fold and other local structures, and the patient was referred for surgical excision. Morphological and immunohistochemical examination of the excised lesion revealed ASPS. The findings of this case are compared with those of seven additional cases of primary laryngeal ASPS, which were found following literature review.

In the structure of oncological morbidity of the upper respiratory tract, malignant tumors of the larynx, including tumors of mesenchymal origin, are the most common. From 1959 to 2013, 55 cases of laryngeal leiomyosarcoma were described in scientific literature. Rarity of this localization of the tumor was the reason for publication of a clinical observation of a patient with endophytic tumor of the right vocal fold. Differential diagnosis for myofibro-, fibro-, and leiomyosarcoma was conducted. Based on immunohistological examination, well-differentiated laryngeal leiomyosarcoma was diagnosed.

Background: Laryngeal mask airway (LMA) insertion contributes to airway protection in patients with a laryngeal tumor around the glottis. There has been no report of LMA insertion itself exacerbating airway obstruction in such patients. Case presentation: A 62-year-old male underwent elective surgical resection of a large laryngeal polyp. The polyp was attached to the right vocal fold and synchronously swung inward into the trachea and outward to the larynx with inspiration and expiration, respectively. Although manual positive pressure ventilation was easily achieved without any airway obstruction after anesthetic induction, the airway was completely obstructed by the polyp lodged between the vocal cords immediately after LMA insertion. Soon after removal of the LMA, patency of the airway was dramatically improved. Conclusion: Our experience indicates that we should pay attention to airway obstruction due to lodging of the polyp between the vocal cords after LMA insertion in patients with a laryngeal polyp., Article, JA CLINICAL REPORTS.4:43(2018)

BACKGROUND Vocal fold injury results in severe voice alteration that limits occupational function and social interaction. An ovine model of laryngeal injury has been developed, validated and utilized to examine laryngeal wound healing and the effect of a novel collagen inhibitor (halofuginone) on surgical wound healing. The study design includes basic research and animal model. METHODS An ovine laryngeal model was utilized to study controlled vocal fold injury and healing. Twenty-five sheep were divided into five groups. Sheep underwent right vocal fold injury preceded or followed by administration of halofuginone orally, topically or intralesionally. Biopsies were taken at commencement, 1 month and larynges explanted at 3 months. Specimens were examined for elastin and collagen density and epithelial changes. Pearson correlation statistics and Student's t-tests were used to assess inter-relationships. RESULTS All sheep tolerated halofuginone. One sheep death occurred in an untreated sheep. Vocal fold tissue demonstrated a predictable histological response to injury. Elastin was significantly reduced post-injury in the glottis. Halofuginone administered orally for 10 weeks prevented elastin loss and demonstrated a trend of reducing collagen density post-injury. CONCLUSION In an ovine laryngeal injury model, administration of a fibrosis inhibitor resulted in altered elastin and collagen deposition after injury in the glottis. Further investigation is warranted to examine whether these tissue changes affect vocal fold dynamics.

Summary Objectives A single case study is reported of a child who underwent several surgical procedures as result of congenital grade III subglottic stenosis. The anterior aspect of the right vocal cord was damaged and underwent atrophy during one of these procedures. Now, an active 10-year-old, the patient has become increasingly aware of his vocal limitations on functional activities. Injection of hyaluronic acid into the vocal folds has been known to provide improved voice quality in adults although there are no known cases reported of this procedure in children. Methods This article reports voice outcomes after injection of hyaluronic acid into the Reinke's space in a single case study. Voice recordings were made before, after, and 1 month after injection. The voice recordings were subject to acoustic and perceptual analysis. Results Post and follow-up voice recordings demonstrate decreased jitter, shimmer, and harmonics-to-noise ratio. Perceptual evaluation indicates improved voice quality. Conclusion Injection of hyaluronic acid in children who require voice augmentation is possible and may contribute to increased vocal function and improved voice outcomes.

A case of laryngeal papilloma with malignant change in a 84-year-old female was reported.This patient has suffered from hoarseness since October 1988. She visited a neighboring ENT clinic and was urged to surgical treatment. However, she waited almost two years without undergoing any treatment. In October 1990, she visited us because of severe difficulty in respiration. A laryngoendoscopy revealed a papillomatous tumor occupying the laryngeal cavity. Successively, she underwent laryngomicrosurgery using the CO2 laser technique. A histopathological study revealed that the tumor was a papilloma with a highly dysplastic change. Unexpectedly, a recurrence was endoscopically found at the right vocal fold in July 1991. Laryngomicrosurgery with a CO2 laser was immediately performed again. Our histopathological division reported that a squamous cell carcinoma was found in part of the specimen.

OBJETIVO: descrever o trabalho fonoaudiológico, após diagnóstico diferencial do cisto intracordal, por meio do exame de videolaringoestroboscopia associado à fonação inspiratória. MÉTODOS: relato de caso, baseado em dados de anamnese, da avaliação clínica fonoaudiológica, do exame videolaringoestroboscópico e conduta terapêutica específica. RESULTADOS: identificação do cisto intracordal em prega vocal direita com alterações encontradas no exame laringológico, compatível à avaliação clínica fonoaudiológica. Verificou-se que, após conduta direcionada, a paciente obteve melhora na vibração e amplitude da onda mucosa da prega vocal direita, com manutenção de períodos de estabilidade vocal. CONCLUSÃO: a eficiência dos procedimentos depende diretamente das avaliações e diagnósticos precisos dos profissionais envolvidos, o que permite uma conduta direcionada ao caso e, menor tempo de tratamento. PURPOSE: to describe the voice therapy after a cyst differential diagnosis by means of videostrobolaryngoscopy associated with inspiratory phonation. METHODS: vase study based on clinical evaluation anamnesis data of phonoaudiologic, videostroboscopic examination, and specific therapeutic conduct. RESULTS: cyst identification in right vocal fold and alterations found in the laryngological examination which were compatible with phonoaudiologic clinical evaluation. After guides speech therapy, we verified evolution in vibration and amplitude of the mucous wave of the right vocal fold, with maintenance of periods as for vocal stability. CONCLUSION: the efficiency of the preceding methods directly depends on the precise evaluations and diagnosis, of the involved professionals, which allows for a conduct guided to the case and less treatment time.

We report a rare case of laryngeal myxoma in a 57-year-old Japanese man. Except for a five-year history of gradually progressive hoarseness, he had been in good health. Video-stroboscopic examination revealed a solid mass in the anterior third of the right vocal fold. Phonosurgery performed with a microscope showed that the mass was encapsulated and located between the epithelium and vocal fold ligaments of the right vocal fold. This hard, elastic mass which measured 7 mm in diameter, was diagnosed as a myxoma. Only three cases of myxoma of the larynx have been reported in the English literature, with only one other case involving the vocal fold.

We report the clinical use of beclomethasone dipropionate inhaler (BDI; Aldecin® inhaler), in the management of contact ulcer and idiopathic granuloma of the larynx.Patient 1 was a 66-year-old woman with an ulcerative lesion at the posterior end of left vocal fold. The lesion was diagnosed as contact ulcer of the larynx and treated by oral spray of BDI, which resulted in improvement in five months.Patient 2 was a 66-year-old man with a small mass at the posterior end of right vocal fold. It was diagnosed as idiopathic granuloma of the larynx and treated by oral spray of BDI. His symptoms and laryngeal lesion markedly improved in three months.BDI appears to be useful in the treatment of contact ulcer and idiopathic granuloma of the larynx.