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This study was conducted to evaluate the effects of whey protein coating incorporated with ohmic-ultrasound (OH-US) pretreated whey protein concentrate (WPC) (1 and 0.5%), Aloysia citrodora essential oil (ACEO) (0.5 and 0.25%) and selenium nanoparticle (SeNPs) (0.5 and 0.25%), separately and in combination on the shelf life extension of chicken breast slices during refrigerated storage (4 °C) over a period of 12 days. The control and treated samples were analyzed for chemical (pH, TVB-N and TBARS), microbial (total mesophilic and psychrotrophic bacteria, Pseudomonas spp., Salmonella typhimurium and Listeria monocytogenes) and sensory properties (odor, color, texture and acceptability). The GC-MS analysis of ACEO disclosed that geranial (28.32%) followed by neral (26.04%), were the most dominant components. The spoilage was significantly suppressed in the samples treated with the fabricated coating, containing different concentrations of WPC hydrolysates (WPCH), ACEO and SeNPs as compared to the control (P

MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded, tiny RNAs with 21-23 nucleotides that regulate several biological functions through binding to target mRNAs and modulating gene expression at post-transcriptional levels. Recent studies have described crucial roles for miRNAs in pathophysiology of numerous human cancers. They can act as an oncogene and promote cancer or as a tumor suppressor and alleviate the disease. Recently discovered microRNA-154 (miR-154) has been proposed to be involved in multiple physiological and pathological processes including cancer. With this aspect, aberrant expression of miR-154 has been demonstrated in variety of human malignancies, suggesting an important role for miR-154 in tumorigenesis. To be specific, it is considered as a tumor suppressor miRNA and exerts its beneficial effects by targeting several genes. This review systematically summarizes the recent advances done on the role of miR-154 in different cancers and discusses its potential prognostic, diagnostic and therapeutic values.

MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded and tiny RNAs that modulate several biological functions, more importantly, the pathophysiology of numerous human cancers. They are bound with target mRNAs and thereby regulate gene expression at post-transcriptional levels. MiRNAs can either trigger cancer progression as an oncogene or alleviate it as a tumor suppressor. Abnormal expression of microRNA-1297 (miR-1297) has been noticed in several human cancers suggesting a distinct role for the miRNA in tumorigenesis. More specifically, it is both up-regulated and down-regulated in various cancers suggesting that it can act as both tumor suppressor and oncogene. This review systematically highlights the different roles of miR-1297 in the pathophysiology of human cancers, explains the mechanisms underlying miR-1297-mediated tumorigenesis, and discusses its potential prognostic, diagnostic, and therapeutic importance.

A 49-day fully randomized trial was conducted to investigate the dietary effects of clove (Syzygium aromaticum L.) essential oil (CEO) on growth performance and oxidative/nitrosative stress biomarkers in broilers under heat stress. A total of 288 male broilers (Ross 308) were randomly divided into 6 dietary groups (4 replicates and 12 birds/replicate) and supplemented as follows: (I) Normal control (NC) received only basal diet under normal condition. The rest of the animals were challenged with heat and assigned to the following groups: (II) Heat stress control (HSC) received only basal diet; (III) Standard treatment (ST) received basal diet + vit E (100 ppm); (IV-VI) Herbal treatments (HT) received basal diet + 250, 350, and 450 ppm CEO. Heat stress could significantly decrease the animals' performance and induce severe oxidative/nitrosative stress. The HT at the middle dose could significantly improve body weight, body weight gain, and feed intake compared to HSC; however, none of the treatments had a significant effect on feed conversion ratio after inducing heat stress. Moreover, both ST and HT with a trend towards concentration-dependent fashion significantly contributed to normalization of oxidative/nitrosative biomarkers. It appears that CEO is a potential replacement for synthetic antioxidants in broiler diets.

Breast, ovarian and uterine cancers are the most common neoplasms among women. Several mechanisms may be involved in oncogenesis and these include environmental and genetic factors. Bacteria may affect the development of some cancers, with bacterial components, their products and metabolites interacting with susceptible tissues. Commensalism and dysbiosis are important potential mechanisms involved in oncogenesis, and an effective strategy for diagnosis and treatment is required. The purpose of this review was to analyze the complex associations between these cancers in women, and the microbiota, specifically bacterial microbes. However, several cancers have an increased prevalence among individuals with HIV and HPV so the relationship between viral infections and malignancies in women is also referred to. We described how different phylum of bacteria, particularly in the gut, mammary tissue and vaginal microbiome may be involved in carcinogenesis; and we discuss the potential pathways involved: (I), that lead to cell proliferation, (II), immune system perturbation, (III), cell metabolic changes (e.g., hormonal factors), and (IV), DNA damage. Studies investigating the differences between the composition of the bacterial microbiota of healthy women compared to that present in various conditions, and the clinical trials are summarized for the few studies that have addressed the microbiota and related conditions, are also reviewed.