1. Evaluation of cyclodextrin polymer as an additive for furosemide tablet
- Author
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Kozo Takayama, Tsuneji Nagai, Eva Fenyvesi, and Jozsef Szejtli
- Subjects
Cyclodextrins ,Chromatography ,Chemistry ,Drug Compounding ,Furosemide ,Excipient ,Starch ,General Chemistry ,General Medicine ,Microcrystalline cellulose ,Excipients ,chemistry.chemical_compound ,Chemical engineering ,Drug Discovery ,Dextrins ,medicine ,Cellulose ,Dissolution ,Computer optimization ,Cyclodextrin polymer ,medicine.drug ,Tablets - Abstract
The effectiveness of cyclodextrin polymer as a disintegrating agent for directly compressed tablets containing furosemide, cyclodextrin polymer and microcrystalline cellulose was investigated. Regression analysis based on statistically designed experiments made it possible to determine how various tablet characteristics are affected by the amount of excipients. As a result of computer optimization an optimum formulation was obtained exhibiting high dissolution rate, sufficient dissolution stability, fast disintegration, high hardness immediately after preparation and adequate hardness after ageing.
- Published
- 1984