1. Synthesis and Pharmacological Activity of Amino Alcohols of the Indole Series
- Author
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V. A. Kuznetsova, T. M. Mitina, N. A. Gurova, N. A. Kolobrodova, Alexander A. Spasov, V. A. Kosolapov, Sophia V. Den’kina, D. S. Yakovlev, Konstantin F. Suzdalev, A. F. Kucheryavenko, D. V. Mal’tsev, O. Yu. Grechko, L. V. Naumenko, and M. N. Babakova
- Subjects
Pharmacology ,Quinidine ,Indole test ,Antioxidant ,Stereochemistry ,medicine.medical_treatment ,Alcohol ,Biological activity ,Ring (chemistry) ,In vitro ,chemistry.chemical_compound ,nervous system ,chemistry ,Drug Discovery ,medicine ,Receptor ,medicine.drug - Abstract
Opening of the oxirane ring in 1-oxiranylmethylindoles yielded new indole derivatives containing 1,2-amino alcohol residues at the nitrogen atom. Compounds were studied in vitro in relation to various types of pharmacological activity typical of this class of compounds, including receptor (5-HT2, 5-HT3, P2Y1-ergic, κ-opioid), antiaggregant, hemorheological, antiarrhythmic, and antioxidant activities.
- Published
- 2013
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