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3 results on '"Brian Ichihara"'

1. Cost-effectiveness of the use of the continuous subcutaneous insulin infusion pump versus daily multiple injections in type 1 diabetes adult patients at the Mexican Institute of Social Security

Author

Ricardo Pérez-Cuevas, Aldo Ferreira-Hermosillo, Casper Barsoe, J.E. Valencia, Ricardo Gasca-Pineda, Erick Gryzbowski, Brian Ichihara, S Roze, Kyla Jones, Jonathan Baran, and Svetlana V. Doubova

Subjects
Insulin pump, Pediatrics, medicine.medical_specialty, Cost effectiveness, Continuous subcutaneous insulin infusion, Context (language use), 03 medical and health sciences, Indirect costs, 0302 clinical medicine, medicine, 030212 general & internal medicine, Mexico, health care economics and organizations, lcsh:R5-920, Incremental cost-effectiveness ratio, Type 1 diabetes, business.industry, Research, 030503 health policy & services, Health Policy, medicine.disease, Quality-adjusted life year, Cohort, lcsh:Medicine (General), 0305 other medical science, business
Abstract

Background To estimate the incremental cost-effectiveness ratio (ICER) of the use of continuous subcutaneous insulin infusion (CSII) therapy versus multiple daily injections (MDI) therapy in adult patients with type 1 diabetes (T1D) at the Mexican Institute of Social Security (IMSS). Methods An analysis was developed using the internationally validated Core Diabetes Model (CDM) with which the incidence and progression of acute and chronic complications and the mortality of T1D was simulated throughout life. The baseline characteristics of the simulated cohorts were obtained from Mexican T1D adult patients aged ≥ 18 years that received care at two national IMSS medical centres in 2016. In the base case, the costs of the complications and treatment of the disease with both therapies were estimated in Mexican currency from the perspective of the institution, using Diagnosis Related Groups for outpatient and inpatient care. Utilities were taken from the international bibliography. In a secondary analysis, indirect costs were included using a human capital approach. The model used a lifetime time horizon, and a discount rate of 5% was applied for health outcomes and costs. A one-way sensitivity analysis was conducted on key variables and patient sub-groups; uncertainty was evaluated using a Cost-Effectiveness Acceptability Curve. Results The average age of the cohort was 32 years, with diabetes duration of 19 years, an average HbA1c of 9.2%; 29% were men. A gain of 0.614 Quality Adjusted Life Years (QALYs) was estimated with the use of CSII therapy. The estimated ICER was MXN$478,020 per QALY in the base case, and MXN$369,593 when indirect costs were considered. The sensitivity analysis showed that, in adult patients with HbA1c > 9.0%, the ICER was MXN$262,237. Conclusions This is the first economic evaluation study that compares CSII therapy versus MDI therapy for T1D adult patients in Mexico. The insulin pump therapy can be considered cost-effective in the context of the IMSS when considering a threshold of three GDPs per capita with 43.9% probability. Results improve substantially when patients have an HbA1c above 9%.

Published
2019
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2. Obesity in Youth with Type 1 Diabetes in Germany, Austria, and the United States

Author

Stephanie N. DuBose, Julia M. Hermann, William V. Tamborlane, Roy W. Beck, Axel Dost, Linda A. DiMeglio, Karl Otfried Schwab, Reinhard W. Holl, Sabine E. Hofer, David M. Maahs, Steven Willi, Terri Lipman, Tammy Calvano, Olena Kucheruk, Pantea Minnock, Chau Nguyen, Georgeanna Klingensmith, Carolyn Banion, Jennifer Barker, Cindy Cain, Peter Chase, Sandy Hoops, Megan Kelsy, David Maahs, Cathy Mowry, Kristen Nadeau, Jennifer Raymond, Marian Rewers, Arleta Rewers, Robert Slover, Andrea Steck, Paul Wadwa, Philippe Walravens, Philip Zeitler, Heidi Haro, Katherine Manseau, Ruth Weinstock, Roberto Izquierdo, Umair Sheikh, Patricia Conboy, Jane Bulger, Suzan Bzdick, Robin Goland, Rachelle Gandica, Lindsay Weiner, Steve Cook, Ellen Greenberg, Kevin Kohm, Sarah Pollack, Joyce Lee, Brigid Gregg, Meng Tan, Kimberly Burgh, Ashley Eason, Satish Garg, Aaron Michels, Lisa Myers, Linda DiMeglio, Tamara Hannon, Donald Orr, Christy Cruz, Stephanie Woerner, Joseph Wolfsdorf, Maryanne Quinn, Olivia Tawa, Andrew Ahmann, Jessica Castle, Farahnaz Joarder, Chris Bogan, Nancy Cady, Jennifer Cox, Amy Pitts, Rebecca Fitch, Brad White, Bethany Wollam, Bruce Bode, Katie Lindmark, RaShonda Hosey, Kathleen Bethin, Teresa Quattrin, Michelle Ecker, Jamie Wood, Lily Chao, Clement Cheung, Lynda Fisher, Debra Jeandron, Francine Kaufman, Mimi Kim, Brian Miyazaki, Roshanak Monzavi, Payal Patel, Pisit Pitukcheewanont, Anna Sandstrom, Marisa Cohen, Brian Ichihara, Megan Lipton, Ayse Cemeroglu, Yaw Appiagyei-Dankah, Maala Daniel, Daniel Postellon, Michael Racine, Michael Wood, Lora Kleis, Irl Hirsch, Anthony DeSantis, D.C. Dugdale, R. Alan Failor, Lisa Gilliam, Carla Greenbaum, Mary Janci, Peggy Odegard, Dace Trence, Brent Wisse, Emily Batts, Angela Dove, Deborah Hefty, Dori Khakpour, Jani Klein, Kristen Kuhns, Marli McCulloch-Olson, Christina Peterson, Mary Ramey, Marissa St. Marie, Pam Thomson, Christine Webber, David Liljenquist, Mark Sulik, Carl Vance, Tiffany Coughenour, Chris Brown, Jean Halford, Andrea Prudent, Shanda Rigby, Brandon Robison, Harold Starkman, Tymara Berry, Barbara Cerame, Daisy Chin, Laurie Ebner-Lyon, Frances Guevarra, Kristen Sabanosh, Lawrence Silverman, Christine Wagner, Marie Fox, Bruce Buckingham, Avni Shah, Kimberly Caswell, Breanne Harris, Richard Bergenstal, Amy Criego, Greg Damberg, Glenn Matfin, Margaret Powers, David Tridgell, Cassie Burt, Beth Olson, LeeAnn Thomas, Sanjeev Mehta, Michelle Katz, Lori Laffel, Joanne Hathway, Roxanne Phillips, Eda Cengiz, William Tamborlane, Darryll Cappiello, Amy Steffen, Melinda Zgorski, Anne Peters, Valerie Ruelas, Robert Benjamin, Deanna Adkins, Juanita Cuffee, Amber Spruill, Grazia Aleppo-Kacmarek, Teresa Derby, Elaine Massaro, Kimberly Webb, Christine Burt Solorzano, Mark DeBoer, Helen Madison, Janet McGill, Lori Buechler, Mary Jane Clifton, Stacy Hurst, Sarah Kissel, Carol Recklein, Eva Tsalikian, Michael Tansey, Joanne Cabbage, Julie Coffey, Sarah Salamati, Mark Clements, Sripriya Raman, Angela Turpin, Jennifer Bedard, Cyndy Cohoon, Aliza Elrod, Amanda Fridlington, Lois Hester, Davida Kruger, Desmond Schatz, Michael Clare-Salzler, Kenneth Cusi, Colleen Digman, Becky Fudge, Mike Haller, Collette Meehan, Henry Rohrs, Janet Silverstein, Sujata Wagh, Miriam Cintron, Eleni Sheehan, Jamie Thomas, Mark Daniels, Susan Clark, Timothy Flannery, Nikta Forghani, Ajanta Naidu, Christina Reh, Peggy Scoggin, Lien Trinh, Natalie Ayala, Rebeca Quintana, Heather Speer, William Zipf, Diane Seiple, Julie Kittelsrud, Ashutosh Gupta, Vikki Peterson, Ashley Stoker, Michael Gottschalk, Marla Hashiguchi, Katheryn Smith, Henry Rodriguez, Craig Bobik, Danielle Henson, Jill Simmons, Amy Potter, Margo Black, Faith Brendle, Rose Gubitosi-Klug, Beth Kaminski, Susan Bergant, Wendy Campbell, Catherine Tasi, Kenneth Copeland, Joni Beck, Joane Less, Jill Schanuel, Jennifer Tolbert, Saleh Adi, Andrea Gerard-Gonzalez, Stephen Gitelman, Nassim Chettout, Christine Torok, Catherine Pihoker, Joyce Yi-Frazier, Susan Kearns, Ingrid Libman, Vicky Bills, Ana Diaz, Julie Duke, Brandon Nathan, Antoinette Moran, Melena Bellin, Shannon Beasley, Anne Kogler, Janice Leschyshyn, Kara Schmid, Anne Street, Bryce Nelson, Carrie Frost, Erin Reifeis, Morey Haymond, Fida Bacha, Maria Caldas-Vasquez, Sara Klinepeter, Maria Redondo, Rosa Berlanga, Teresa Falk, Elizabeth Garnes, Janette Gonzalez, Cecilia Martinez, Mariam Pontifes, Ronald Yulatic, Kathleen Arnold, Traci Evans, Sharon Sellers, Vandana Raman, Carol Foster, Mary Murray, Trina Brown, Hillarie Slater, Karen Wheeler, David Harlan, Mary Lee, John-Paul Lock, Celia Hartigan, Lisa Hubacz, John Buse, Ali Calikoglu, Joseph Largay, Laura Young, Helen Brown, Vinnie Duncan, Michelle Duclos, Julie Tricome, Verdayne Brandenburg, Julie Blehm, Julie Hallanger-Johnson, Dawn Hanson, Corliss Miller, Jennifer Weiss, Robert Hoffman, Monika Chaudhari, David Repaske, Elizabeth Gilson, Jesse Haines, Justen Rudolph, Charles McClave, Doris Biersdorf, Anthony Tello, Donna Amundson, Rhonda Ward, Michael Rickels, Cornelia Dalton-Bakes, Eileen Markman, Amy Peleckis, Nora Rosenfeld, Lawrence Dolan, Sarah Corathers, Jessica Kichler, Holly Baugh, Debbie Standiford, Jeanne Hassing, Jennifer Jones, Stephen Willis, Carol Wysham, Lisa Davis, Scott Blackman, Kimber-Lee Abel, Loretta Clark, Andrea Jonas, Ellie Kagan, Jay Sosenko, Carlos Blashke, Della Matheson, Rachel Edelen, Thomas Repas, Denise Baldwin, Trista Borgwardt, Christina Conroy, Kelly DeGrote, Rod Marchiando, Michelle Wasson, Larry Fox, Nelly Mauras, Ligeia Damaso, Kim Englert, Marwan Hamaty, Laurence Kennedy, Michelle Schweiger, Pantelis Konstantinopoulos, Carolyn Mawhorter, Amy Orasko, Denise Rose, Larry Deeb, Kim Rohrbacher, Leroy Schroeder, Amanda Roark, Omar Ali, Joanna Kramer, Donna Whitson-Jones, Heidi Gassner, Sobha Kollipara, Katerina Harwood, Vijaya Prasad, and Judy Brault

Subjects
Male, Pediatrics, medicine.medical_specialty, endocrine system diseases, Adolescent, MEDLINE, Hypoglycemia, Body Mass Index, Diabetes mellitus, Germany, medicine, Humans, Obesity, Registries, Child, Glycemic, Glycated Hemoglobin, Type 1 diabetes, business.industry, nutritional and metabolic diseases, medicine.disease, Institutional review board, United States, Diabetes Mellitus, Type 1, Austria, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, business, Body mass index, Demography
Abstract

To examine the current extent of the obesity problem in 2 large pediatric clinical registries in the US and Europe and to examine the hypotheses that increased body mass index (BMI) z-scores (BMIz) are associated with greater hemoglobin A1c (HbA1c) and increased frequency of severe hypoglycemia in youth with type 1 diabetes (T1D).International (World Health Organization) and national (Centers for Disease Control and Prevention/German Health Interview and Examination Survey for Children and Adolescents) BMI references were used to calculate BMIz in participants (age 2-18 years and ≥ 1 year duration of T1D) enrolled in the T1D Exchange (n = 11,435) and the Diabetes Prospective Follow-up (n = 21,501). Associations between BMIz and HbA1c and severe hypoglycemia were assessed.Participants in both registries had median BMI values that were greater than international and their respective national reference values. BMIz was significantly greater in the T1D Exchange vs the Diabetes Prospective Follow-up (P.001). After stratification by age-group, no differences in BMI between registries existed for children 2-5 years, but differences were confirmed for 6- to 9-, 10- to 13-, and 14- to 17-year age groups (all P.001). Greater BMIz were significantly related to greater HbA1c levels and more frequent occurrence of severe hypoglycemia across the registries, although these associations may not be clinically relevant.Excessive weight is a common problem in children with T1D in Germany and Austria and, especially, in the US. Our data suggest that obesity contributes to the challenges in achieving optimal glycemic control in children and adolescents with T1D.

Published
2014

3. Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone

Author

Lars Klemm, Emily Ng, Rocky Pramanik, Reuben Antony, Steven D. Mittelman, Xia Sheng, Brian Ichihara, and Ehsan A. Ehsanipour

Subjects
Cancer Research, medicine.medical_specialty, Calcitriol, Apoptosis, vitamin D deficiency, Dexamethasone, Article, Internal medicine, hemic and lymphatic diseases, Cell Line, Tumor, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, medicine, Vitamin D and neurology, Cytotoxic T cell, Humans, Cell Proliferation, business.industry, Hematology, medicine.disease, Leukemia, Endocrinology, Oncology, Cancer cell, Cancer research, business, medicine.drug
Abstract

Vitamin D deficiency has been linked with increased cancer risk, and vitamin D has been shown to be cytotoxic to some cancer cells in vitro. In the present study we evaluated whether vitamin D would have antiproliferative or cytotoxic effects on human pre-B acute lymphoblastic leukemia cells. Contrary to our hypotheses, calcitriol, the active form of vitamin D, had no effect on leukemia cell proliferation. Calcitriol actually had a modest effect to impair dexamethasone cytotoxicity and induction of apoptosis. Further studies are needed to evaluate the effects of vitamin D on leukemia cells in vivo.

Published
2011

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