Search

Summary The report concerns a family “with autosomally inherited diabetes insipidus of the pituitary form. A detailed description is given of a boy who was hospitalized for long periods during his first three years and then showed the dehydration, fever, vomiting, constipation and retarded development hitherto only observed in the nephrogenic form of diabetes insipidus. The child, who is now 14 years old, has an I.Q. of 58 according to Terman-Merrill. One of his father's sisters, who also has diabetes insipidus, is severely mentally retarded. In view of the fact that mental retardation has now been observed in two genetically different forms of diabetes insipidus, the authors reject the hypothesis of it being the effect of a pleiotropic gene. The authors stress how important it is to include a copious amount of fluid in the diet of children who have or might have diabetes insipidus of any form. Description d'un cas de diabete insipide genetique du type hypophysaire presentant l'aspect d'un diabete insipide du type renal. Cet article concerne une famille ou l'on rencontre des cas de diabete insipide hereditaire du type hypophygaire chez des membres des deux sexes. Les auteurs decrivent en detail le cas d'un garcon qui avait ete hospitalise durant de longues periodes au eours des trois premieres annees de son existence et se mit alors a presenter les phenomenes de deshydratation, fievre, vomissements, constipation et arrieration que l'on n'avait jusqu'alors observes que dans la forme renale du diabete insipide. Cet enfant, qui est maintenant âge de 14 ans, presente un quotient intellectuel de 58 selon la table de Terman-Merrill. Une des soeurs de son pere. qui est egalement atteinte de diabete insipide, souffre d'arrieration mentale severe. Puisque l'arrieration mentale a desormais ete observee dans deux formes genetiquement differentes du diabete insipide, les auteurs rejettent l'hypothese d'apres laquelle cette maladie serait due a l'intervention d'un gene pleiotrope. Les auteurs attirent l'attention sur l'iniportance de l'abondance des liquides dans le regime des enfants atteints ou susceptibles d'etre atteints d'une forme queleonque du diabete insipide. Ein Fall von genetischem Diabetes insipidus von hypophysarem Typus mit scheinbar nephrogenen Symptomen. Der Bericht betrifft eine Familie mit autosomatisch vererbtem Diabetes insipidus von hypophysarem Typus. Eine eingehende Beschreibung ernes Jungen wird dargeboten, welcher wahrend der ersten drei Lebensjahre im Hospital behandelt wurde und die Symptome von Wasserverlust, Fieber, Erbrechen, Verstopfung und Entwicklungshemmung aufwies, wie sie bisher nur in der nephrogenen Form des Diabetes insipidus beobachtet worden waren. Bei dem gegenwartig 14 Jahre alten Kinde betragt der Intelligenzquotient nach Terman-Merrill 58. Eine Schwester seines Vaters, auch mit Diabetes insipidus behaftet, ist geistig sehr stark zuruckgeblieben. Im Hinblick auf die Tatsache, dass geistige Hemmung in zwei genetisch verschiedenartigen Formen des Diabetes insipidus beobachtet worden ist, lehnen die Verfasser die Hypothese, dass er von einem pleiotropischen Gen bewirkt werde, ab. Die Verfasser betonen mit Nachdruck, wie wichtig es sei, reichliche Flussigkeitsmengen in der Diat von Kindern mit ausgesprochenem oder vermutetem Diabetes insipidus, einzuschliessen. Un caso de diabetes insipida genetica del tipo pituitario simulando tipo nefrogeno. En esta relacion se expone el caso de una familia presentando diabetes insipida autosoma hereditaria en forma pituitaria. Se describe detalladamente el caso de un nino hospitalizado por largos espacios de tiempo durante sus tres primeros anos de edad y que luego manifesto la deshidratacion, fiebre, los vomitos, estrenimiento y desarrollo atrasado, observados hasta entonces en la forma nefrogena de la diabetes insipida. El nino, que cumple en la actualidad 14 anos de edad, tiene un I.Q. de 58, de acuerdo con Terman-Merrill. Una de las hermanas de su padre, que tambien padece diabetes insipida, presenta un severo atraso mental. En vista del hecho de que ahora el atraso mental ha sido observado en dos formas geneticas distintas de diabetes insipida, los autores refutan la hipotesis de que pudiera tratarse de los efectos de un gen pleotropico. Los autores subrayan insistentemente la importancia de incluir una cantidad copiosa de liquido en la dieta de los ninos que manifiesten, o puedan manifestar, cualquier forma de diabetes insipida.

An investigation material consisting of 120 persons who were born after refusal of an application for therapeutic abortion, with the same number of controls, has previously been followed up by the writers to the age of 21 years. This follow-up study has now been extended to completion of the 35th year. It is found that in social-psychiatric respects the index cases as a group are still somewhat worse situated than the control cases. However, the differences have to a certain extent levelled out and during the later part of the observation period no statistically significant differences can be demonstrated for any single variable.This second follow-up study of 120 Swedish patients who were born between 1939-42 after refusal of therapeutic abortions extends the study to their 35th year. Individual information on economic support, criminal record, psychiatric care, health, and marriage/divorce was obtained from local social service authorities. Comparison was made with a 2nd control group. The results of the extended observation reveals a decrease in the differences between the 2 groups although the test group continues to show more frequent records of social and psychiatric difficulties. Over the extended period the differences have leveled out and no statistically significant differences can be demonstrated for any single variable.

In the mid-1960.s, reports came from Scotland and England of a high frequency of gonosomal aberrations among male patients in maximum security hospitals (Jacobs et al., 1965; Casey et al., 1966). This led to a lively discussion. If these observations could be generalized so as to apply also to similar institutions in other countries, the question would be whether gonosomal aneuploidy had any bearing on the development of criminality and psychic diseases? In particular, the significance of a double Y condition as a predisposing factor was called in question. Unfortunately, from the outset the discussion became too categorical and oversimplified. When in subsequent studies socially well-adjusted individuals of normal intelligence were found, it was doubted whether aneuploidy had any importance at all. In a survey as recent as 1972, for example, Owen questions whether there is any connection at all between excess Y-chromosomes and behaviour disorders and mental diseases. Hook (1973), on the contrary, in a somewhat more detailed compilation, shows that there is a clear connection between the occurrence of double Y-chromosomes and individuals whom he defines as ‘mental-penal’. A common feature in all the literature, however, is that almost all writers insist on the importance of more research in this field.

120 children born in 1939-1942 after their mothers had applied for therapeutic abortion on psychiatric grounds and had been refused were compared with an appropriate control group of the same size. Many more unwanted than control children had not had the advantage of a secure family life during childhood. There was a statistically significant difference (p

Many of the links in the chain of circumstances leading to anorexia nervosa are still not clear. Ever since Sir William Gull in 1868 first described and in, 874 named the condition, investigators have put most of the blame for it on psychological circumstances, such as an adverse relationship between mother and daughter. Tolstrup (1967), after reviewing the observations of a long list of authors, concluded that no physical explanation of note was forth-coming. Another of the many adherents of the psychogenetic school is Thomä (1961).