1. Childhood Overweight, Tallness, and Growth Increase Risks of Ovarian Cancer
- Author
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Nicolas Wentzensen, Lian G. Ulrich, Britton Trabert, Julie Aarestrup, Jennifer L. Baker, and Thorkild I. A. Sørensen
- Subjects
Adult ,0301 basic medicine ,Oncology ,Pediatric Obesity ,medicine.medical_specialty ,endocrine system diseases ,Epidemiology ,Disease ,Overweight ,Article ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Humans ,Medicine ,Young adult ,Aged ,Aged, 80 and over ,Ovarian Neoplasms ,2. Zero hunger ,business.industry ,Hazard ratio ,Middle Aged ,medicine.disease ,Obesity ,Body Height ,female genital diseases and pregnancy complications ,3. Good health ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cohort ,Female ,medicine.symptom ,business ,Ovarian cancer ,Body mass index - Abstract
Background: Adult body size is related to ovarian cancer risks, but size in childhood may also influence risks. We investigated if childhood body mass index (kg/m2), height, and growth patterns were associated with ovarian cancer overall and by histologic subtypes, including effects of birthweight. Methods: A cohort of 155,958 girls from the Copenhagen School Health Records Register, born 1930 to 1989 with measured weights and heights from 7 to 13 years, were included. During follow-up, 1,041 ovarian cancers were recorded. Overweight was defined using International Obesity Task Force criteria. Cox regressions were performed. Results: Compared with non-overweight girls, at most ages girls with overweight had increased risks of ovarian cancer overall (HR range: 1.24–1.34), mucinous, endometrioid, and clear cell ovarian cancers, but not serous and other ovarian cancers. Childhood height had positive and significant associations with ovarian cancer overall (HR range: 1.07–1.10 per z-score) and the endometrioid subtype but not with the other subtypes. Adjusting for birthweight minimally altered the associations with childhood body size. In growth analyses, girls with overweight or who were tall at 7 and 13 years had increased risks of ovarian cancer overall compared with average-sized girls at both ages. Conclusions: Ovarian carcinogenesis is linked to childhood overweight, tallness, and growth, with variations across histological subtypes, suggesting that early life plays a role in the origins of this disease. Impact: These findings emphasize that healthy body size and growth during childhood are important as they may contribute to reducing ovarian cancer risks.
- Published
- 2019