43 results on '"Lincoln E"'
Search Results
2. Isolation, characterization, and distribution of somatostatin receptor subtype 2 (SSTR 2) mRNA in rainbow trout (Oncorhynchus mykiss), and regulation of its expression by glucose
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Mark A. Sheridan, Lincoln E. Martin, Barton J. Slagter, and Jeffrey D. Kittilson
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Fish Proteins ,medicine.medical_specialty ,Physiology ,Molecular Sequence Data ,Gene Expression ,In Vitro Techniques ,Biology ,Biochemistry ,Internal medicine ,Complementary DNA ,Gene expression ,medicine ,Animals ,Amino Acid Sequence ,RNA, Messenger ,Receptors, Somatostatin ,Receptor ,Molecular Biology ,Phylogeny ,Regulation of gene expression ,Messenger RNA ,Base Sequence ,Sequence Homology, Amino Acid ,Somatostatin receptor ,Open reading frame ,Glucose ,medicine.anatomical_structure ,Endocrinology ,Gene Expression Regulation ,Liver ,Organ Specificity ,Oncorhynchus mykiss ,Pancreas - Abstract
In this study, cDNA for a somatostatin receptor variant (somatostatin receptor subtype 2, SSTR 2) was isolated, cloned, and sequenced from rainbow trout. A 1821-nt cDNA was isolated and found to contain a single initiation site 387-nt from the most 5' end, an open reading frame of 1116-nt, and a single putative polyadenylation site 189-nt from the most 3' end. The encoded protein contains 372 amino acids and contains seven membrane-spanning domains. Based on structural analysis, the protein was identified as a subtype 2 SSTR. These data support the emergence of a multigenic SSTR family early in the course of vertebrate evolution, concomitant with or perhaps prior to the divergence of boney fish. The distribution of SSTR 2 mRNA in tissues was determined by quantitative real time-PCR (QRT-PCR). SSTR 2 was most abundant in the brain (where it was detected in the telencephalon, optic tectum, and hypothalamus), skeletal muscle, and liver, but it also was present in the endocrine pancreas (Brockmann body) and various regions of the gastrointestinal tract (esophagus, stomach, intestine). SSTR 2 mRNA was most abundant in the brain, muscle, and liver. In vitro the Brockmann body and liver with increasing concentrations of glucose (1, 4, 10mM) resulted in increased expression of SSTR 2 mRNA. These findings contribute to the understanding of the evolution of the SSTR family and provide insight into the roles of SSTR 2 in fish. more...
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- 2011
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Catalog
3. Maximal stimulation-induced in situ myosin light chain kinase activity is upregulated in fetal compared with adult ovine carotid arteries
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Renan Joel Sandoval, William J. Pearce, Lincoln E. Ford, Elisha R. Injeti, James M. Williams, and Alexander V. Smolensky
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Aging ,medicine.medical_specialty ,Myofilament ,Myosin Light Chains ,Time Factors ,Myosin light-chain kinase ,Carotid Artery, Common ,Physiology ,chemistry.chemical_element ,Stimulation ,macromolecular substances ,Naphthalenes ,Calcium ,Biology ,Myosin light chain kinase activity ,Myosin-Light-Chain Phosphatase ,Fetus ,Calmodulin ,Physiology (medical) ,Internal medicine ,Myosin ,medicine ,Animals ,Enzyme Inhibitors ,Phosphorylation ,Myosin-Light-Chain Kinase ,Oxazoles ,Sheep ,Dose-Response Relationship, Drug ,Age Factors ,Articles ,Azepines ,Up-Regulation ,Endocrinology ,chemistry ,Vasoconstriction ,Marine Toxins ,Myosin-light-chain phosphatase ,medicine.symptom ,Cardiology and Cardiovascular Medicine - Abstract
Postnatal decreases in vascular reactivity involve decreases in the thick filament component of myofilament calcium sensitivity, which is measured as the relationship between cytosolic calcium concentration and myosin light chain (MLC20) phosphorylation. The present study tests the hypothesis that downregulation of thick filament reactivity is due to downregulation of myosin light chain kinase (MLCK) activity in adult compared with fetal arteries. Total MLCK activity, calculated as %MLC20phosphorylated per second in intact arteries during optimal inhibition of myosin light chain phosphatase activity, was significantly less in adult (6.56 ± 0.29%) than in fetal preparations (7.39 ± 0.53%). In situ MLC20concentrations (μM) in adult (198 ± 28) and fetal arteries (236 ± 44) did not differ significantly. In situ MLCK concentrations (μM), however, were significantly greater in adult (8.21 ± 0.59) than in fetal arteries (1.83 ± 0.13). In situ MLCK activities (ng MLC20phosphorylated·s−1·ng MLCK−1) were significantly less in adult (0.26 ± 0.01) than in fetal arteries (1.52 ± 0.11). In contrast, MLCK activities in adult (15.8 ± 1.5) and fetal artery homogenates (17.3 ± 1.3) were not significantly different. When in situ fractional activation was calculated, adult values (1.72 ± 0.17%) were significantly less than fetal values (9.08 ± 0.83%). Together, these results indicate that decreased thick filament reactivity in adult compared with fetal ovine carotid arteries is due at least in part to greater MLCK activity in fetal arteries, which in turn cannot be explained by differences in MLCK, MLC20, or calmodulin concentrations. Instead, this difference appears to involve age-related differences in fractional activation of the MLCK enzyme. more...
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- 2008
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4. Comparison of safety and efficacy of ERCP performed with the patient in supine and prone positions
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Lincoln E V V C Ferreira and Todd H. Baron
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Male ,medicine.medical_specialty ,Abdominal pain ,Percutaneous ,Supine position ,Biliary Tract Diseases ,Sedation ,Risk Assessment ,Sensitivity and Specificity ,Statistics, Nonparametric ,Prone Position ,Supine Position ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Probability ,Retrospective Studies ,Cholangiopancreatography, Endoscopic Retrograde ,business.industry ,Gastroenterology ,Pancreatic Diseases ,Retrospective cohort study ,Middle Aged ,Surgery ,Prone position ,Anesthesia ,Midazolam ,Female ,Safety ,medicine.symptom ,Complication ,business ,Follow-Up Studies ,medicine.drug - Abstract
Background ERCP is usually performed with the patient in the prone position. Little data exist on ERCP in the supine position, which is considered unsafe in nonintubated patients. Objective Our purpose was to compare outcomes of ERCP in the prone and supine positions. Design Retrospective study. Setting Tertiary care medical center. Patients All patients undergoing ERCP by one endoscopist over an 18-month period. Main Outcome Measurements American Society of Anesthesiologists (ASA) score, procedural degree of difficulty, procedural time, success rates, complication rates, effects on oxygen desaturation and hemodynamics, amount of sedation, need for precut sphincterotomy. Results A total of 649 patients were evaluated, of whom 506 patients were prone and 143 were supine. There were no differences between the groups with regard to sex, procedural time, ASA scores, need for precut sphincterotomy, adverse cardiovascular events, episodes of oxygen desaturation, dose of meperidine or midazolam, or oxygen supplementation. Complete success and complication rates were similar for both groups (90.2% and 11.2% for supine and 92.5% and 9.1% for prone, respectively). Procedural degree of difficulty was significantly higher in the supine group ( P Limitations Retrospective study, one endoscopist. Conclusions ERCP performed in nonintubated patients placed supine is often more difficult and may lead to more mild adverse respiratory events than when performed with the patient prone. Supine ERCP is appropriate in certain patients who cannot lie prone (abdominal pain, abdominal distention, ascites, recent abdominal or neck surgery, indwelling percutaneous tubes and need for access during the procedure to indwelling internal/external percutaneous biliary catheters, and in the morbidly obese) with more intensive monitoring in those who are not intubated. more...
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- 2008
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5. Mechanism and significance of early, rapid shortening in sensitized airway smooth muscleThis article is one of a selection of papers published in the Special Issue on Recent Advances in Asthma Research
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Susan H. Gilbert and Lincoln E. Ford
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Pharmacology ,medicine.medical_specialty ,Reactive airway disease ,Contraction (grammar) ,Physiology ,Chemistry ,General Medicine ,Airway obstruction ,medicine.disease ,medicine.anatomical_structure ,Endocrinology ,CrossBridge ,Physiology (medical) ,Internal medicine ,Myosin ,medicine ,Respiratory system ,Sensitization ,Respiratory tract - Abstract
It has been reported that sensitization of animals to allergens increases both early shortening velocity and myosin light-chain kinase of their airway smooth muscle without increasing force generated by these muscles. Since early shortening sets muscle length for the duration of a contraction, these responses might be expected to produce greater airway obstruction. Here, it is explained how the more rapid early shortening without increased force production is predicted by the 2-stage process of activation followed by contraction posited by the crossbridge theory of contraction when the rate, but not the extent, of activation is increased. The experimental results are reproduced by a simple model in which activation rate is increased 1.6-fold without any other changes in contractile parameters. These results reinforce suggestions that sensitized animals are a model for reactive airway disease. more...
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- 2007
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6. Inhibition of myosin light-chain phosphorylation inverts the birefringence response of porcine airway smooth muscle
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Alexander V. Smolensky, Susan H. Gilbert, Margaret Harger-Allen, and Lincoln E. Ford
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medicine.medical_specialty ,Myofilament ,Myosin light-chain kinase ,Physiology ,Skeletal muscle ,macromolecular substances ,Biology ,Wortmannin ,chemistry.chemical_compound ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Internal medicine ,Myosin ,medicine ,Trachealis muscle ,Biophysics ,Myocyte ,Actin - Abstract
Muscle birefringence, caused mainly by parallel thick filaments, increases in smooth muscle during stimulation, signalling thick filament formation upon activation. The reverse occurs in skeletal muscle, where a decrease in birefringence has been correlated with crossbridge movement away from the thick filaments. When force generation by trachealis muscle was inhibited with wortmannin, which inhibits myosin light-chain phosphorylation and thick-filament formation, but not the calcium increase caused by stimulation, the birefringence response inverted, suggesting crossbridge movement similar to that of skeletal muscle. Resistance to quick stretches was much greater in stimulated muscle than in unstimulated muscle before wortmannin treatment and no different in stimulated and unstimulated muscle after force inhibition by wortmannin. Before wortmannin treatment, stimulation reduced thick-filament cross-sectional areas in electron micrographs by 44%. After force inhibition by wortmannin, filament areas were not significantly different in stimulated and unstimulated muscle and not significantly different from those of relaxed muscle without wortmannin treatment. These results suggest that myofibrillar-space calcium causes crossbridges to move away from the thick filaments without firmly attaching to thin filaments. more...
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- 2007
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7. The importance of maturational studies in airway smooth muscle
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Susan H. Gilbert and Lincoln E. Ford
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Pulmonary and Respiratory Medicine ,Pediatrics ,medicine.medical_specialty ,education.field_of_study ,Physiology ,business.industry ,Incidence (epidemiology) ,Population ,Cell Biology ,Airway smooth muscle ,Disease ,medicine.disease ,Surgery ,Physiology (medical) ,medicine ,business ,education ,Asthma - Abstract
asthma affects 17.7 million Americans, 5 million of them children ([41][1]). Its incidence has more than doubled in the general population since 1980, with a disproportionate increase in children under the age of 4 ([41][1]). Measures of the yearly burden of this disease, 5,500 deaths ([31][2]) more...
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- 2005
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8. Differing Effects of Inotropic Agents on Length Change Deactivation of Isolated Rat Myocardium
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Betty J. Skipper, John M. Perea, Laura A. Grimes, Lincoln E. Ford, and John K. Leach
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Inotrope ,Cardiac function curve ,medicine.medical_specialty ,Cardiotonic Agents ,Contraction (grammar) ,Epinephrine ,chemistry.chemical_element ,Isometric exercise ,In Vitro Techniques ,Calcium ,General Biochemistry, Genetics and Molecular Biology ,Rats, Sprague-Dawley ,Caffeine ,Internal medicine ,medicine ,Animals ,Cardiac muscle ,General Medicine ,Papillary Muscles ,Myocardial Contraction ,Rats ,Surgery ,medicine.anatomical_structure ,chemistry ,Length change ,Cardiology ,medicine.drug - Abstract
Background A rapid change in length of cardiac muscle during isometric contraction is followed by developed force that is less than appropriate for the new length because of deactivation of the contractile system. Length change deactivation may have favorable or unfavorable effects on cardiac function, depending on the circumstances under which it is produced. Methods Left ventricular papillary muscles from male Sprague-Dawley rats were arranged for recording of isometric force. After each control or reference isometric contraction, a quick release-quick stretch V-step was applied to the following contraction. For each repetition of control and experimental contractions, the time of application of V-steps was increased by 20 ms until peak force was reached. Effects of these V-steps were assessed from ratios of peak redeveloped force to peak force in an isometric reference contraction. Slopes of plots of these ratios versus time after the onset of the contraction were used to quantify the effects of inotropic agents on deactivation. Results Increasing calcium from 2.5 to 5.0 or 7.5 mM increased force by 12±4% (mean±SEM), did not change time to peak, and did not significantly alter the deactivation slope. Adding 5 mM epinephrine increased force by 16±5%, decreased time to peak by 34±3%, and increased the deactivation slope by 106±9% ( PConclusions The quantitatively different effects of the three agents on length change deactivation slopes and time to peak force suggest a common mechanism, probably involving thin-filament cooperativity. more...
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- 2002
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9. Outpatient Management of Heart Failure
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Lincoln E. Ford
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Adult ,Male ,medicine.medical_specialty ,Digoxin ,Adrenergic beta-Antagonists ,Hemodynamics ,Angiotensin-Converting Enzyme Inhibitors ,chemistry.chemical_compound ,Internal medicine ,Ambulatory Care ,medicine ,Humans ,Diuretics ,Carvedilol ,Aged ,business.industry ,General Medicine ,Middle Aged ,Hydralazine ,medicine.disease ,Angiotensin II ,Blood pressure ,chemistry ,Heart failure ,Cardiology ,Spironolactone ,Drug Therapy, Combination ,Female ,Cardiomyopathies ,Cardiology and Cardiovascular Medicine ,business ,Anti-Arrhythmia Agents ,medicine.drug - Abstract
The outpatient treatment of heart failure can be divided into 2 broad categories: older therapies, which improve hemodynamics, and newer therapies, which increase survival and improve function. Hemodynamic "triple" therapy includes digoxin to increase cardiac inotropy, antihypertensives to lower systolic pressure, and diuretics to remove fluid and decrease filling pressures. Disease-modifying therapy requires the use of specific agents to lower blood pressure (angiotensin-converting enzyme inhibitors, angiotensin II blockers, spironolactone, or hydralazine and nitrates) and beta-adrenergic blockade with carvedilol. The success of these newer therapies suggests that the standard triple therapy for heart failure should be expanded to "quadruple" therapy that includes carvedilol. more...
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- 1999
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10. Covered expandable metal stent placement for treatment of a refractory pancreatic duct leak
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Lincoln E V V C Ferreira and Todd H. Baron
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Aged, 80 and over ,Male ,Pancreatic duct ,Leak ,medicine.medical_specialty ,business.industry ,Biliary Tract Diseases ,medicine.medical_treatment ,Gastroenterology ,Stent ,Surgery ,Radiography ,Stent placement ,medicine.anatomical_structure ,Refractory ,medicine ,Humans ,Cholecystectomy ,Stents ,Radiology, Nuclear Medicine and imaging ,Endoscopy, Digestive System ,Radiology ,business - Published
- 2007
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11. Environmental estrogens inhibit growth of rainbow trout (Oncorhynchus mykiss) by modulating the growth hormone-insulin-like growth factor system
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Lincoln E. Martin, Jeffrey D. Kittilson, Andrea M. Hanson, and Mark A. Sheridan
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Gills ,medicine.medical_specialty ,medicine.medical_treatment ,Growth hormone receptor ,Biology ,Environment ,Growth hormone ,Real-Time Polymerase Chain Reaction ,Insulin-like growth factor ,Endocrinology ,Insulin-Like Growth Factor II ,Internal medicine ,medicine ,Juvenile ,Animals ,RNA, Messenger ,Insulin-Like Growth Factor I ,Receptor ,Insulin-like growth factor 1 receptor ,Messenger RNA ,Reverse Transcriptase Polymerase Chain Reaction ,Muscles ,Estrogens ,Receptors, Somatomedin ,Receptors, Somatotropin ,Liver ,Growth Hormone ,Oncorhynchus mykiss ,Animal Science and Zoology ,Rainbow trout - Abstract
Although environmental estrogens (EE) have been found to disrupt a wide variety of developmental and reproductive processes in vertebrates, there is a paucity of information concerning their effects on organismal growth, particularly postembryonic growth. In this study, we exposed juvenile rainbow trout (Oncorhynchus mykiss) to 17β-estradiol (E2) β-sitosterol (βS), or 4-n-nonylphenol (NP) to assess the effects of EE on overall organismal growth and on the growth hormone-insulin-like-growth factor (GH-IGF) system. EE treatment significantly reduced food conversion, body condition, and body growth. EE-inhibited growth resulted from alterations in peripheral elements of the GH-IGF system, which includes multiple GH receptors (GHRs), IGFs, and IGF receptors (IGFRs). In general, E2, βS, and NP reduced the expression of GHRs, IGFs, and IGFRs; however, the effects varied in an EE-, tissue-, element type-specific manner. For example, in liver, E2 was more efficacious than either βS, and NP in reducing GHR expression, and the effect of E2 was greater on GHR 1 than GHR2 mRNA. By contrast, in gill, all EEs affected GHR expression in a similar manner and there was no difference in the effect on GHR1 and GHR 2 mRNA. With regard to IGF expression, all EEs reduced hepatic IGF1 and IGF2 mRNA levels, whereas as in gill, only E2 and NP significantly reduced IGF1 and IGF2 expression. Lastly, E2 and NP reduced the expression of IGFR1A and IGFR1B mRNA expression similarly in gill and red and white muscle, whereas βS had no effect on expression of IGFR mRNAs. These findings indicate that EEs disrupt post-embryonic growth by reducing GH sensitivity, IGF production, and IGF sensitivity. more...
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- 2013
12. Endoscopic stenting for palliation of malignant biliary obstruction
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Lincoln E V V C Ferreira and Todd H. Baron
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medicine.medical_specialty ,Cholestasis ,medicine.diagnostic_test ,business.industry ,Bile duct ,Biomedical Engineering ,Endoscopy ,General Medicine ,Jaundice ,equipment and supplies ,Stent patency ,Stent occlusion ,surgical procedures, operative ,medicine.anatomical_structure ,Medicine ,Biliary stent ,Humans ,Surgery ,Endoscopic stenting ,In patient ,Stents ,Radiology ,medicine.symptom ,business - Abstract
Malignant biliary obstruction results in jaundice, often with symptoms that decrease the quality of life. Biliary stent placement has largely supplanted surgical bypass for palliation of malignant biliary obstruction. Traditional rigid plastic stents are commonly used, inexpensive and easily removed, although with limited duration of stent patency. Self-expandable metal stents (SEMS) attain larger luminal diameters and provide longer patency than traditional rigid plastic stents in patients with distal bile duct obstruction. SEMS are composed of a variety of metals and can be uncoated, partially covered, or fully covered. Data do not support a prolongation of patency with covered SEMS for distal obstruction, although they have the potential for removability. The data to support SEMS for palliation of hilar biliary obstruction are not as convincing and reintervention for stent occlusion can be difficult. In this article, the design and performance of expandable metal stents for treatment of malignant biliary obstruction will be reviewed. more...
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- 2010
13. Endoscopic Treatment of Pancreatic Disease
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Lincoln E V V C Ferreira and Todd H. Baron
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medicine.medical_specialty ,Pancreatic disease ,business.industry ,Internal medicine ,medicine ,business ,medicine.disease ,Endoscopic treatment ,Gastroenterology - Published
- 2010
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14. Shortening velocity and power output of skinned muscle fibers from mammals having a 25,000-fold range of body mass
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Chun Y. Seow and Lincoln E. Ford
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medicine.medical_specialty ,Maximum power principle ,Fold (higher-order function) ,Physiology ,Muscle Relaxation ,Isometric exercise ,Body size ,Mice ,Isometric Contraction ,Internal medicine ,medicine ,Animals ,Range (particle radiation) ,Sheep ,Lagomorpha ,biology ,Muscles ,Body Weight ,Rats, Inbred Strains ,Articles ,biology.organism_classification ,Rats ,Muscle relaxation ,Endocrinology ,Shortening velocity ,Mice, Inbred CBA ,Biophysics ,Cattle ,Rabbits - Abstract
The shortening velocities of single, skinned, fast and slow skeletal muscle fibers were measured at 5-6 degrees C in five animal species having a 25,000-fold range of body size (mouse, rat, rabbit, sheep, and cow). While fiber diameter and isometric force showed no dependence on animal body size, maximum shortening velocity in both fast and slow fibers and maximum power output in fast fibers were found to vary with the -1/8 power of body size. Maximum power output in slow fibers showed a slightly greater (-1/5 power) dependence on body size. The isometric force produced by the fibers was correlated (r = 0.74) inversely with fiber diameter. For all sizes of animal the average maximum velocity was 1.7 times faster in fast fibers than in slow fibers. The large difference in mechanical properties found between fibers from large and small animals suggests that properties of the contractile proteins vary in a systematic manner with the body size. These size-dependent changes can be used to study the correlations of structure and function of these proteins. Experimental results also suggest that the different metabolic rates observed in different sizes of animals could be accounted for, at least in part, by the difference in the properties of the contractile proteins. more...
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- 1991
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15. Tetanized Cardiac Muscle
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Robert Forman and Lincoln E. Ford
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medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Internal medicine ,Cardiac muscle ,medicine ,Cardiology ,business - Published
- 2008
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16. Zenker's diverticula: pathophysiology, clinical presentation, and flexible endoscopic management
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Lincoln E V V C Ferreira, Dia T. Simmons, and Todd H. Baron
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Zenker Diverticulum ,Myotomy ,medicine.medical_specialty ,medicine.medical_treatment ,Zenker's diverticulum ,Esophagus ,otorhinolaryngologic diseases ,medicine ,Humans ,Digestive System Surgical Procedures ,medicine.diagnostic_test ,business.industry ,General surgery ,Gastroenterology ,General Medicine ,medicine.disease ,Dysphagia ,Endoscopy ,Surgery ,Pharyngoesophageal Diverticulum ,Cricopharyngeal myotomy ,Esophagoscopy ,medicine.symptom ,business ,Deglutition Disorders ,Diverticulum - Abstract
Zenker's diverticulum (ZD) is the most common type of diverticulum in the upper gastrointestinal tract. Most patients are elderly and present with symptoms of dysphagia. Serious complications include aspiration and malnutrition. The most common treatments are open surgical diverticulectomy with or without cricopharyngeal myotomy and rigid endoscopic myotomy. Recently, cricopharyngeal myotomy using flexible endoscopes has been described as a treatment option for symptomatic ZD. In this article we describe the pathophysiology, clinical presentation and review the techniques and outcome following flexible endoscopic management of Zenker's diverticulum. more...
- Published
- 2008
17. Post-sphincterotomy bleeding: who, what, when, and how
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Todd H. Baron and Lincoln E V V C Ferreira
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Bleeding episodes ,medicine.medical_specialty ,Endoscopic retrograde cholangiopancreatography ,Hepatology ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Incidence ,Gastroenterology ,Postoperative Hemorrhage ,Endoscopy ,Surgery ,Sphincterotomy, Endoscopic ,Refractory ,Biliary tract ,Biliary sphincterotomy ,Risk Factors ,Angiography ,medicine ,Humans ,Embolization ,business ,Algorithms - Abstract
Endoscopic biliary sphincterotomy (ES) is the cornerstone of therapeutic endoscopic retrograde cholangiopancreatography (ERCP). Bleeding is one of the most frequent complications following ES. Rates of post-ES bleeding vary widely and its presentation may be immediate (intraprocedural) or several days later. Clinically, bleeding can range from insignificant to life threatening. Most bleeding episodes are managed successfully by conservative measures with or without endoscopic therapy. Endoscopic treatment options include injection, thermal, and mechanical methods-alone or in combination. For refractory cases, angiographic embolization, or surgery, is necessary. Both technical risk factors and patient risk factors contribute to the development of post-ES bleeding. When these risk factors are present, measures can be taken to reduce the risk of bleeding. In this manuscript the literature on post-ES bleeding is reviewed. more...
- Published
- 2007
18. Airway smooth muscle dynamics: A common pathway of airway obstruction in asthma
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Robert H. Brown, Alan L. James, Paul G. Smith, Kenneth R. Lutchen, Reinoud Gosens, Michael J. Sanderson, Lu Wang, S. H. Gilbert, R. H. Ingram, Thai Tran, Robert S. Tepper, David H. Eidelman, Peter D. Paré, Steven S. An, Geoffrey N. Maksym, Pasquale Chitano, Peter J. Sterk, Ben Fabry, Thomas M. Murphy, Newman L. Stephens, Darryl A. Knight, Linhong Deng, Thais Mauad, Richard W. Mitchell, William T. Gerthoffer, Paulo Sérgio Panse Silveira, Howard W. Mitchell, Alastair G. Stewart, O. J. Lakser, S. J. Gunst, Judith L. Black, Srboljub M. Mijailovich, Nigel J. Fairbank, James G. Martin, Dale D. Tang, Jeffrey J. Fredberg, Wayne Mitzner, Brent E. McParland, Mara S. Ludwig, Anne-Marie Lauzon, Tony R. Bai, Lincoln E. Ford, Charles G. Irvin, Vito Brusasco, R. Robert Schellenberg, Maria Dowell, Jason H. T. Bates, Luke J. Janssen, Chun Y. Seow, Riccardo Pellegrino, Gregory G. King, Julian Solway, Andrew J. Halayko, Molecular Pharmacology, Engineering and Technology Institute Groningen, and Groningen Research Institute for Asthma and COPD (GRIAC) more...
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Pathology ,Pathophysiology of asthma ,Physiological ,Apoptosis ,Respiratory physiology ,urologic and male genital diseases ,Article ,immune system diseases ,Internal medicine ,Medicine ,Humans ,Adaptation ,Asthma ,MÚSCULOS DO SISTEMA RESPIRATÓRIO ,Lung ,business.industry ,Muscle adaptation ,Respiratory disease ,Muscle, Smooth ,Airway obstruction ,respiratory system ,medicine.disease ,Adaptation, Physiological ,respiratory tract diseases ,Respiratory Function Tests ,Airway Obstruction ,medicine.anatomical_structure ,Cardiology ,Respiratory Mechanics ,Muscle ,Smooth ,Bronchial Hyperreactivity ,business ,Airway ,Muscle Contraction - Abstract
Excessive airway obstruction is the cause of symptoms and abnormal lung function in asthma. As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is suspected that dysfunction of ASM contributes to the pathophysiology of asthma. However, the precise role of ASM in the series of events leading to asthmatic symptoms is not clear. It is not certain whether, in asthma, there is a change in the intrinsic properties of ASM, a change in the structure and mechanical properties of the noncontractile components of the airway wall, or a change in the interdependence of the airway wall with the surrounding lung parenchyma. All these potential changes could result from acute or chronic airway inflammation and associated tissue repair and remodelling. Anti-inflammatory therapy, however, does not "cure" asthma, and airway hyperresponsiveness can persist in asthmatics, even in the absence of airway inflammation. This is perhaps because the therapy does not directly address a fundamental abnormality of asthma, that of exaggerated airway narrowing due to excessive shortening of ASM. In the present study, a central role for airway smooth muscle in the pathogenesis of airway hyperresponsiveness in asthma is explored. more...
- Published
- 2007
19. Force and myosin light chain phosphorylation in dog airway smooth muscle activated in different ways
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Joseph Ragozzino, Richard W. Mitchell, Lincoln E. Ford, and Theodor Burdyga
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inorganic chemicals ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Myosin light-chain kinase ,Myosin Light Chains ,Physiology ,Pyridines ,macromolecular substances ,Biology ,In Vitro Techniques ,environment and public health ,Potassium Chloride ,Wortmannin ,chemistry.chemical_compound ,Dogs ,Internal medicine ,Isometric Contraction ,Myosin ,medicine ,Animals ,Enzyme Inhibitors ,Phosphorylation ,Oxazoles ,Tetany ,Dose-Response Relationship, Drug ,Kinase ,General Neuroscience ,Muscle, Smooth ,Amides ,Acetylcholine ,Electric Stimulation ,Y-27632 ,Androstadienes ,Trachea ,enzymes and coenzymes (carbohydrates) ,Endocrinology ,chemistry ,Trachealis muscle ,Biophysics ,bacteria ,Marine Toxins ,Calyculin - Abstract
To assess activation mechanisms of dog trachealis muscle and test whether isometric force generation could be separated from myosin light-chain (MLC) phosphorylation, force and phosphorylation were measured in the presence of wortmannin (a light-chain kinase inhibitor) or Y-27632 (a rho-kinase inhibitor) during electrically stimulated tetani and sustained contractures induced by acetylcholine, KCl, or calyculin A, a light-chain phosphatase inhibitor which caused irreversible contractures and both di- and mono-phosphorylation of light chain. Phosphorylation was not much more than half under any circumstances. A nearly constant proportionality between steady force and phosphorylation existed over a 9-fold force range during contractures and 25-sec tetani, except that force correlated best with the di-phosphorylated light chain produced by calyculin A. Phosphorylation was disproportionately higher than force at the outset of tetani, and this disproportion was exaggerated by Y-27632. The results suggest that about half the light chain is sequestered from kinases and that mechanical activation is tightly linked to phosphorylation, except at the outset of stimulation. more...
- Published
- 2003
20. Gender- and height-related limits of muscle strength in world weightlifting champions
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Lincoln E. Ford, Kevin K. Ho, Alvin J. Detterline, and Wenyuan Cao
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medicine.medical_specialty ,Sex Characteristics ,Weight Lifting ,Physiology ,Body height ,Body Weight ,Anatomy ,Anthropometry ,Body weight ,Body Height ,Physical medicine and rehabilitation ,Human muscle ,Physical performance ,Physiology (medical) ,medicine ,Muscle strength ,Humans ,Muscle fibre ,Psychology ,Muscle, Skeletal ,Body mass index - Abstract
To assess factors that limit human muscle strength and growth, we examined the relationship between performance and body dimensions in the world weightlifting champions of 1993–1997. Weight lifted varied almost exactly with height squared (Ht2.16), suggesting that muscle mass scaled almost exactly with height cubed (Ht3.16) and that muscle cross-sectional area was closely correlated with body height, possibly because height and the numbers of muscle fibers in cross section are determined by a common factor during maturation. Further height limitations of muscle strength were shown by only one male champion ≥183 cm and no female champions ≥175 cm. The ratio of weight lifted to mean body cross-sectional area was approximately constant for body-weight classes ≤83 kg for men and ≤64 kg for women and decreased abruptly for higher weight classes. These findings suggest a nearly constant fraction of body mass devoted to muscle in lighter lifters and a lesser fraction in heavier lifters. Analysis also suggests that contractile tissue comprises ∼30% less body mass in female champions. more...
- Published
- 2000
21. The importance of biomechanical feedback in the generation of asthma
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Lincoln E. Ford
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medicine.medical_specialty ,Medical education ,Physiology ,business.industry ,Myocytes, Smooth Muscle ,Alternative medicine ,Muscle, Smooth ,medicine.disease ,Physiology (medical) ,medicine ,Animals ,business ,Myosin-Light-Chain Kinase ,Asthma - Abstract
those of us who pursue biological research do so mainly because of the intellectual satisfaction derived from making discoveries. But we are blessed with generous grants from our governments whose motivations are more practical and include improving the health of our populations, promoting new more...
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- 2011
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22. Corrigendum
- Author
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Todd H. Baron and Lincoln E V V C Ferreira
- Subjects
medicine.medical_specialty ,business.industry ,Biomedical Engineering ,Medicine ,Surgery ,Endoscopic stenting ,General Medicine ,business - Published
- 2011
- Full Text
- View/download PDF
23. Inotropic mechanism of myocardium
- Author
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Lincoln E. Ford
- Subjects
Inotrope ,medicine.medical_specialty ,Contraction (grammar) ,business.industry ,Cardiac muscle ,Muscle mechanics ,Post extrasystolic potentiation ,medicine.anatomical_structure ,Isoproteronol ,Internal medicine ,Beta-Adrenergic Agonist ,Myosin ,medicine ,Cardiology ,business - Published
- 1992
- Full Text
- View/download PDF
24. 'Idiopathic' Acute Pancreatitis Due To Biliary Sludge: Prevention of Relapses by Endoscopic Biliary Sphincterotomy in High-Risk Patients
- Author
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Julio Maria Fonseca Chebli, Lincoln E V V C Ferreira, Ângelo Paulo Ferrari, Liliana Andrade Chebli, Pedro Duarte Gaburri, Aécio Flávio Meirelles de Souza, and Manoel Martins das Neves
- Subjects
Adult ,Male ,medicine.medical_specialty ,Gastroenterology ,Sphincterotomy, Endoscopic ,Recurrence ,Internal medicine ,medicine ,Bile ,Humans ,Biliary sludge ,Aged ,Aged, 80 and over ,High risk patients ,Hepatology ,business.industry ,Bilirubin ,Middle Aged ,medicine.disease ,Surgery ,Idiopathic acute pancreatitis ,Cholesterol ,Pancreatitis ,Biliary sphincterotomy ,Acute Disease ,Acute pancreatitis ,Female ,Crystallization ,business - Abstract
“idiopathic” acute pancreatitis due to biliary sludge: prevention of relapses by endoscopic biliary sphincterotomy in high-risk patients
- Published
- 2000
- Full Text
- View/download PDF
25. A New Approach to Therapeutic ERCP After Long-Limb Roux-En-Y Gastric Bypass Surgery: A Porcine Study
- Author
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Lincoln E V V C Ferreira, Todd H. Baron, and Thomas C. Smyrk
- Subjects
medicine.medical_specialty ,Gastric bypass surgery ,business.industry ,Gastroenterology ,medicine ,Radiology, Nuclear Medicine and imaging ,medicine.disease_cause ,business ,Roux-en-Y anastomosis ,Surgery - Published
- 2008
- Full Text
- View/download PDF
26. Utility of a Fully Covered Metal Stent for the Treatment of Benign Esophageal Conditions
- Author
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Lincoln E V V C Ferreira, Todd H. Baron, and Louis-Michel Wong Kee Song
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Gastroenterology ,medicine ,Stent ,Radiology, Nuclear Medicine and imaging ,Radiology ,business - Published
- 2008
- Full Text
- View/download PDF
27. Bouveret’s Syndrome: Diagnosis and Endoscopic Treatment
- Author
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Lincoln E V V C Ferreira, Todd H. Baron, and Mark Topazian
- Subjects
Aged, 80 and over ,Cholangiopancreatography, Endoscopic Retrograde ,medicine.medical_specialty ,S syndrome ,Hepatology ,Gastric Outlet Obstruction ,business.industry ,General surgery ,Gastroenterology ,Gallstones ,Syndrome ,Endoscopy, Gastrointestinal ,Diagnosis, Differential ,Text mining ,Lithotripsy ,medicine ,Humans ,Female ,Duodenal Obstruction ,Tomography, X-Ray Computed ,business ,Endoscopic treatment - Published
- 2008
- Full Text
- View/download PDF
28. Management of Clinically Significant Bleeding Following Endoscopic Sphincterotomy
- Author
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Todd H. Baron and Lincoln E V V C Ferreira
- Subjects
medicine.medical_specialty ,business.industry ,Gastroenterology ,Medicine ,Radiology, Nuclear Medicine and imaging ,business ,Surgery - Published
- 2007
- Full Text
- View/download PDF
29. The hypoxic cytotoxin sr 4233 enhances the antitumor activity of radioimmunotherapy in scid mice bearing transplanted human t cell lymphomas (ASTRO research fellowship)
- Author
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Michael L. Goris, Lincoln E. Moses, Andrew I. Minchinton, Richard B. Wilder, W. Sutherland, Susan J. Knox, Edmund K. Waller, and Judeth K. McGann
- Subjects
Antitumor activity ,Cancer Research ,Pathology ,medicine.medical_specialty ,Radiation ,business.industry ,medicine.medical_treatment ,T cell ,Scid mice ,medicine.anatomical_structure ,Oncology ,Radioimmunotherapy ,Cancer research ,Medicine ,Radiology, Nuclear Medicine and imaging ,business - Published
- 1992
- Full Text
- View/download PDF
30. AIDS: Perspectives on Public Health, Policy, and Administration
- Author
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Vivian E. Fransen, Walter J. Jones, James A. Johnson, Lincoln E. Moses, Charles F. Tumer, and Heather G. Miller
- Subjects
Marketing ,Gerontology ,medicine.medical_specialty ,Public Administration ,Sociology and Political Science ,Acquired immunodeficiency syndrome (AIDS) ,Political science ,Family medicine ,medicine ,medicine.disease ,Community-based care ,Administration (government) ,Public health policy - Published
- 1991
- Full Text
- View/download PDF
31. AIDS: The Second Decade
- Author
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Heather G. Miller, Lincoln E. Moses, and Charles F. Turner
- Subjects
medicine.medical_specialty ,Acquired immunodeficiency syndrome (AIDS) ,business.industry ,Family medicine ,Medicine ,business ,medicine.disease ,Social Sciences (miscellaneous) ,Demography - Published
- 1991
- Full Text
- View/download PDF
32. AIDS: The Second Decade
- Author
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[John Bongaarts], Heather G. Miller, Charles F. Turner, and Lincoln E. Moses
- Subjects
medicine.medical_specialty ,Sociology and Political Science ,Intravenous drug ,business.industry ,Behavior change ,Human immunodeficiency virus (HIV) ,MEDLINE ,Human sexuality ,Development ,medicine.disease_cause ,medicine.disease ,Sexual behavior ,Acquired immunodeficiency syndrome (AIDS) ,Intervention (counseling) ,Family medicine ,medicine ,Psychiatry ,business ,Demography - Abstract
Expanding on the 1989 National Research Council volume AIDS, Sexual Behavior, and Intravenous Drug Use, this book reports on changing patterns in the distribution of cases and the results of intervention efforts under way. It focuses on two important subpopulations that are becoming more and more at risk: adolescents and women. The committee also reviews strategies to protect blood supplies and to improve the quality of surveys used in AIDS research.AIDS: The Second Decade updates trends in AIDS cases and HIV infection among the homosexual community, intravenous drug users, women, minorities, and other groups; presents an overview of a wide range of behavioral intervention strategies directed at specific groups; discusses discrimination against people with AIDS and HIV infection; and presents available data on the proportion of teenagers engaging in the behaviors that can transmit the virus and on female prostitutes and HIV infection. more...
- Published
- 1990
- Full Text
- View/download PDF
33. Social Science, Human Behavior, and the AIDS Epidemic
- Author
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Padraig O'Malley, Ronald Bayer, William W. Darrow, Heather G. Miller, Lincoln E. Moses, and Charles F. Turner
- Subjects
medicine.medical_specialty ,Sociology and Political Science ,Intravenous drug ,business.industry ,Public health ,Criminology ,Public relations ,medicine.disease ,Public interest ,Politics ,Acquired immunodeficiency syndrome (AIDS) ,Sexual behavior ,Political science ,medicine ,Private rights ,Social consequence ,business - Published
- 1990
- Full Text
- View/download PDF
34. Dimensional Correlates of Left Ventricular Dilation in the Presence of Hypertrophy
- Author
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Lincoln E. Ford, Mamoun B. Al-Nouri, and Herschel Wix
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,Cardiac Catheterization ,medicine.medical_specialty ,Left ventricular dilation ,animal structures ,Heart Ventricles ,Heart Valve Diseases ,Cardiomegaly ,Critical Care and Intensive Care Medicine ,Muscle hypertrophy ,Valvular disease ,Internal medicine ,Humans ,Medicine ,cardiovascular diseases ,Cardiac Output ,Ejection fraction ,business.industry ,Ventricular dilatation ,valvular heart disease ,Hemodynamics ,Stroke Volume ,Middle Aged ,equipment and supplies ,medicine.disease ,Echocardiography ,Hypertension ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Twelve normal subjects, 50 patients with valvular heart disease, and 14 with hypertension were studied. Those with valvular disease were divided into two groups: 28 with angiographically measured ejection fractions greater than or equal to 0.6 and 22 with ejection fractions less than 0.6. The echocardiographically measured ventricular thickness divided by radius ratio (t/r) was approximately proportional to peak systolic pressure (P) in all groups having ejection fractions greater than or equal to 0.6, so that the t/r divided by P ratios were nearly the same. Patients with ejection fractions less than 0.6 had significantly lower t/r divided by P values. No single component of the t/r divided by P ratio would identify the patients with lower ejection fractions. The t/r divided by P ratios in 14 hypertensive patients were nearly identical to the ratios in six patients with aortic stenosis and ejection fractions greater than or equal to 0.6, indicating that an aortic valve gradient does not cause a grossly abnormal form of pressure hypertrophy. The t/r ratio is thus a double sensitive, noninvasive index of dilation when correlated with systolic pressure. more...
- Published
- 1983
- Full Text
- View/download PDF
35. Unequal Corrected Visual Acuity as Related to Anisometropia
- Author
-
Arthur Jampolsky, Lincoln E. Moses, Bernice C. Flom, and Frank W. Weymouth
- Subjects
medicine.medical_specialty ,Visual acuity ,genetic structures ,business.industry ,Visual Acuity ,Refractive Errors ,medicine.disease ,Refraction ,Anisometropia ,Ophthalmology ,Socioeconomic Factors ,Statistical analyses ,medicine ,Humans ,Optometry ,Statistical analysis ,medicine.symptom ,business ,Vision, Ocular - Abstract
It is well known that corrected acuity in ametropia is usually normal, or approximately so, but is sometimes markedly reduced. In many cases this low acuity occurs in eyes which appear normal, even to careful examination. Often the corrected acuity differs markedly in the two eyes; for example, one may be 20/15 and the other 20/40. In some cases unequal acuity is known to be associated with unequal refraction or anisometropia. Anisometropia, it is generally agreed, presents difficult problems of correction. Many writers have speculated regarding the possible relations of corrected acuity to refractive conditions, but satisfacory statistical analyses are lacking. The clinical importance of the problems, particularly in the correction of anisometropia in children, justifies a reexamination of the question with material selected to present those refractive conditions mentioned. The present study is an attempt to apply adequate statistical analysis to appropriate data. SOURCE OF DATA AND TERMINOLOGY The more...
- Published
- 1955
- Full Text
- View/download PDF
36. AN IMPROVED BIOASSAY METHOD FOR THYROTROPIC HORMONE USING THYROID UPTAKE OF RADIOPHOSPHORUS12
- Author
-
William Lew, Lincoln E. Moses, Joseph P. Kriss, and Francis S. Greenspan
- Subjects
endocrine system ,medicine.medical_specialty ,Pituitary gland ,Thyroid uptake ,Chemistry ,Thyroid ,Stimulation ,Phosphorus metabolism ,Guinea pig ,Endocrinology ,medicine.anatomical_structure ,Internal medicine ,medicine ,Bioassay ,Hormone - Abstract
ARAPID, accurate, and sensitive method is needed for the bioassay of hypophyseal thyrotropic hormone (TSH). Borell, in 1945, demonstrated an increase in total phosphorus content of the thyroid gland following stimulation with TSH. This observation led Borell and Holmgren in 1949 to the use of radioactive phosphorus (P32) uptake of the thyroid of the guinea pig as an indicator of TSH activity. Later, Crooke and Matthews (1953), and Lamberg (1953), presented bioassay methods utilizing P32 uptake of the one day old chick. This report describes modifications in the radiophosphorus uptake methods which increase the accuracy and sensitivity of the assay and decrease the work required. Abstracts of this work have been reported previously (Greenspan, et al.z, 1954; Kriss and Greenspan, 1954). more...
- Published
- 1956
- Full Text
- View/download PDF
37. A plastic anemia following prolonged administration of chloramphenicol; a report of two cases, one a fatality
- Author
-
O. O. Witherbee, Julius Kahn, Lincoln E. Wilson, H. H. Henstell, and M.. S. Harris
- Subjects
Pediatrics ,medicine.medical_specialty ,Bronchiectasis ,Dose ,Drug-Related Side Effects and Adverse Reactions ,medicine.drug_class ,business.industry ,Chloramphenicol ,Antibiotics ,Anemia, Aplastic ,Anemia ,medicine.disease ,Surgery ,Penicillin ,Streptomycin ,medicine ,Sputum ,Aplastic anemia ,medicine.symptom ,business ,Plastics ,medicine.drug - Abstract
Following prolonged administration of chloramphenicol, two cases of aplastic anemia, one of which ended fatally, were encountered. In a study to be reported elsewhere by one of us (M. S. H.), on the effects of chloramphenicol in the bacteriostatic control of chronic bronchopulmonary suppuration, 62 patients, ranging in age from 1 year to 72 years, were given the drug over periods of from 1 month to 14 months. Dosages of 1 gm., two to three times weekly and, in a few instances, daily, were administered after an initial period of more intensive antibiotic therapy, which included penicillin and/ or streptomycin. Thus, in a controlled series, 2 of 62 patients receiving the drug for long periods had severe hematological complications. In the two cases of aplastic anemia to be reported, the first of which ended fatally, the drug was given for approximately seven months and five and one-half months, respectively. REPORT more...
- Published
- 1952
38. Scientific Foundations of Cardiology
- Author
-
Lincoln E. Ford
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,media_common.quotation_subject ,Cardiology ,medicine ,Cover (algebra) ,Quality (business) ,General Medicine ,business ,media_common - Abstract
This large and useful book is the latest in aScientific Foundationsseries dealing with various topics in medicine. It contains 73 chapters, each well circumscribed and directed at a highly specific topic. Most of the nearly 100 authors are well known and the quality of the writing is quite high. The editors are to be congratulated on their choice of collaborators. The 73 chapters are arranged into major sections, most of which deal with clinical topics. The arrangement requires that each chapter be independent of the others, so that each can be read without reference to other parts of the book. Part of the usefulness of the book is that each small segment can be read and understood on its own. The book does not make a great effort to cover every area of cardiology completely; the authors seen to have had the freedom to write on topics of more...
- Published
- 1984
- Full Text
- View/download PDF
39. AIDS: Sexual Behavior and Intravenous Drug Use
- Author
-
[John Bongaarts], Charles F. Turner, Heather G. Miller, and Lincoln E. Moses
- Subjects
medicine.medical_specialty ,Sociology and Political Science ,business.industry ,Social phenomenon ,Public health ,Behavior change ,Social change ,Psychological intervention ,Disease ,Development ,medicine.disease ,Acquired immunodeficiency syndrome (AIDS) ,Family medicine ,Medicine ,business ,Psychiatry ,Demography ,Social behavior - Abstract
Since the acquired immunodeficiency syndrome (AIDS) epidemic is partly a social phenomenon changes in the social behaviors that spread the disease are as necessary as the development of vaccines and other therapies. To help in the design implementation and evaluation of programs to curb the spread of AIDS there is a need for greater understanding of the human behaviors that transmit human immunodeficiency virus (HIV) infection as well as the social contexts in which these behaviors occur. Toward this end the US Committee on AIDS Research and the Behavioral Social and Statistical Sciences was asked to: 1) describe what is known about the spread of HIV and AIDS in the US with special attention to the quality of information at hand and the kind of additional information that is needed; 2) identify critical populations and indicate objectives and tasks related to them; 3) describe existing research findings in the behavioral and social sciences that should be useful in planning and choosing among interventions designed to control the spread of HIV infection; 4) describe existing research on interventions intended to facilitate behavior changes and ways to evaluate their effectiveness; and 5) identify new research that should be undertaken in these areas. The 7 chapters of the resultant report are divided into 3 parts: Understanding the Spread of HIV Infection; Intervening to Limit the Spread of HIV Infection; and Impediments to Research and Intervention. Also included are 6 background papers. Among the recommendations of the Committee are: vigorous programs of basic social and behavioral research on human sexual behavior; availability of condoms and treatment for sexually transmitted diseases through local public health authorities; drug treatment upon request for intravenous drug users; trials of sterile needle programs; and anonymous HIV antibody testing with appropriate counseling on a voluntary basis. more...
- Published
- 1989
- Full Text
- View/download PDF
40. The Evaluation of Hospital Death Rates
- Author
-
Lincoln E. Moses
- Subjects
medicine.medical_specialty ,business.industry ,Mortality rate ,medicine.medical_treatment ,MEDLINE ,General Medicine ,Disease ,medicine.disease ,Age groups ,Emergency medicine ,Medicine ,Confidentiality ,Medical emergency ,business ,Human services ,Cardiac catheterization - Abstract
The article by Luft and Hunt 1 in this issue ofThe Journalhas acquired an urgent relevancy since it was accepted for publication. In that time interval, the Department of Health and Human Services has begun to release individually identified hospital death rates. Luft and Hunt examined the 1982 experience of patients undergoing cardiac catheterization in the 151 member hospitals of the Commission on Professional and Hospital Activities known to have had cardiac catheterization laboratories in that year. Confidentiality mechanisms ensured that the authors were blind to the identity of the hospitals from which the data came. The age of the patient and the patient's disease are both powerful influences on the probability of death, so the investigators sorted the patients into 12 categories, defined as the possible combinations of three age groups and four diagnostic groups. For each of these 12 categories, the whole-study death rate (across the more...
- Published
- 1986
- Full Text
- View/download PDF
41. Rheumatoid-like Arthritis Associated With a Colonic Carcinoma
- Author
-
Richard D. Simon and Lincoln E. Ford
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Acute joint effusion ,business.industry ,Arthritis ,medicine.disease ,Gastroenterology ,Surgery ,Internal medicine ,Internal Medicine ,medicine ,Rheumatoid factor ,business ,Colonic Carcinoma - Abstract
• A 76-year-old woman with rapidly progressive arthritis associated with a rising rheumatoid factor, acute joint effusion, and fever had remission of her symptoms and return of her laboratory values to normal following removal of a colonic carcinoma. ( Arch Intern Med 140:698-700, 1980) more...
- Published
- 1980
- Full Text
- View/download PDF
42. Planning and Analysis of Observational Studies
- Author
-
William G. Cochran, Lincoln E. Moses, Frederick Mosteller, and Nigel C. Smeeton
- Subjects
Statistics and Probability ,medicine.medical_specialty ,Computer science ,medicine ,Medical physics ,Observational study - Published
- 1984
- Full Text
- View/download PDF
43. Statistics of Therapeutic Trials
- Author
-
G. Herdan and Lincoln E. Moses
- Subjects
Statistics and Probability ,medicine.medical_specialty ,business.industry ,medicine ,Statistics, Probability and Uncertainty ,Intensive care medicine ,business ,Therapeutic trial - Published
- 1956
- Full Text
- View/download PDF
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