28 results on '"Miriam A. Knoll"'
Search Results
2. Clinical Cancer Advances 2021: ASCO's Report on Progress Against Cancer
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Timothy J. Moynihan, Robert G. Uzzo, Merry Jennifer Markham, Noelle K. LoConte, Daniel A. Mulrooney, Melissa Lynne Johnson, Miriam A. Knoll, Jane L. Meisel, Nathan A. Pennell, Daniel J. George, Helen Mackay, Douglas E. Peterson, Kerri Wachter, Ryan J. Sullivan, Olatoyosi Odenike, Katherine E. Reeder-Hayes, Therese M. Mulvey, Sonali M. Smith, Johanna C. Bendell, Howard A. Burris, Robert Dreicer, Muhammad Shaalan Beg, Randall J. Kimple, Kathryn Finch Mileham, Vicki L. Keedy, Cardinale B. Smith, and Richard L. Schilsky
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Cancer Research ,2019-20 coronavirus outbreak ,medicine.medical_specialty ,Biomedical Research ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MEDLINE ,Medical Oncology ,Neoplasms ,Pandemic ,medicine ,Humans ,Precision Medicine ,Intensive care medicine ,Pandemics ,Societies, Medical ,SARS-CoV-2 ,business.industry ,COVID-19 ,Cancer ,Precision medicine ,medicine.disease ,United States ,Oncology ,Neoplasms diagnosis ,business - Published
- 2021
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3. #ThisIsBrachytherapy: Increasing awareness of brachytherapy
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Chirag Shah, Jenna M. Kahn, Ashley Albert, Shauna R. Campbell, and Miriam A. Knoll
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medicine.medical_specialty ,business.industry ,Sentiment score ,medicine.medical_treatment ,Brachytherapy ,Australia ,United States ,Influencer marketing ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,Physicians ,030220 oncology & carcinogenesis ,Family medicine ,Health care ,Radiation oncology ,Radiation Oncology ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Social media ,business ,Social Media - Abstract
Purpose The use of brachytherapy continues to be a vital application of radiation oncology for various cancers. Despite this, there has been a decrease in the utilization of brachytherapy in many cancers. Social media in medicine facilitates engagement and advocacy. We launched a social media campaign to bring awareness of brachytherapy throughout the world with #ThisIsBrachytherapy hashtag on July 17, 2019. Methods and Materials #ThisIsBrachytherapy hashtag was registered with Symplur Healthcare Hashtag Project. We collected total tweet counts, retweet counts, impression counts, geolocation, top 10 influencers, associated hashtags, associated words, and word sentiment score. Results The campaign launched on July 17, 2019, had a total of 145 tweets on that day with 213,416 impressions. Twenty-seven accounts (45%) were identified as physicians. Top countries which tweeted, among those with information available, included the United States, United Kingdom, and Australia. Since July 17, 2019, there has been an increase in tweets using #ThisIsBrachytherapy, with 1990 total tweets with 1,999,248 impressions. Fifty-four percent (1030) of the tweets contained photos and 319 contained links. This was from 462 unique users. Word sentiment was overwhelmingly positive. Associated hashtags with #ThisIsBrachytherapy included most commonly #radonc, #brachytherapy, #brachy, #prostatecancer, and #pcsm. Conclusions The #ThisIsBrachytherapy inaugural campaign was successful and has continued to grow throughout the months after the initiation. By continuing to advocate for brachytherapy through the social media campaign #ThisIsBrachytherapy, we can empower radiation oncologists, especially trainees, and patients to address underutilization.
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- 2021
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4. Gender Diversity in Radiation Oncology Board Certification
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Reshma Jagsi, Paul E. Wallner, and Miriam A. Knoll
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Male ,Cancer Research ,medicine.medical_specialty ,Certification ,Radiation ,Gender diversity ,business.industry ,Extramural ,MEDLINE ,Sex Factors ,Oncology ,Sex factors ,Specialty Boards ,Family medicine ,Radiation oncology ,Radiation Oncology ,Humans ,Medicine ,Female ,Radiology, Nuclear Medicine and imaging ,Board certification ,business - Published
- 2020
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5. Thank you to those who Peer Reviewed in 2018 for Advances in Radiation Oncology
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Chiaojung Jillian Tsai, Isabel L. Jackson, Catheryn M. Yashar, Miriam A. Knoll, Sinae Kim, William Small, Sharad Goyal, Dawit Tegbaru, Kathleen M. Hintenlang, Gregory M.M. Videtic, Bradford S. Hoppe, Curtiland Deville, and Robert C. Miller
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medicine.medical_specialty ,Editorial ,Oncology ,business.industry ,Radiation oncology ,Medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,business - Published
- 2019
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6. Gender & Racial/Ethnic Disparities in Academic Oncology Leadership
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K. Patel, Gavin P. Jones, Narjust Duma, Mudit Chowdhary, Akansha Chowdhary, Miriam A. Knoll, Curtiland Deville, N. Dhawan, Trevor J. Royce, Arpit M. Chhabra, Neha Vapiwala, and Karen M. Winkfield
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Intersectionality ,Oncology ,Cancer Research ,medicine.medical_specialty ,Radiation ,business.industry ,Ethnic group ,White female ,Racial ethnic ,Test (assessment) ,Internal medicine ,Workforce ,Radiation oncology ,Medicine ,Radiology, Nuclear Medicine and imaging ,Training program ,business - Abstract
Purpose/Objective(s) Gender & racial/ethnic leadership disparities have been independently identified in academic hematology/oncology (HO) and radiation oncology (RO). Here, we evaluate gender and racial/ethnic intersectionality from the trainee to the leadership level. Materials/Methods All ACGME accredited HO and RO training program websites were queried to identify constituent trainees, academic faculty, program directors (PD) and department chairs (DC), with a leadership position defined as PD or DC. Individual gender & race/ethnicity was determined using externally validated software tools, publicly available descriptors, and image review. We grouped individuals into 6 categories: White Male (WM), White Female (WF), Asian Male (AM), Asian Female (AF), Underrepresented Groups in Medicine (as defined by AAMC) Male (URMM) and Female (URMF). The chi-squared goodness-of-fit test was applied to examine if deviations exist between the observed vs. expected proportions of gender/race dyads in trainees, PD, and DC compared to academic faculty. Results We identified 7,722 individuals from 2019-2020: 1,759 trainees (HO = 1525; RO = 234), 5,726 faculty (HO = 4834; RO = 892), 242 PD (HO = 149; RO = 93) and 237 DC (HO = 144; RO = 93). Leadership positions were most often comprised by WM (52.6%), and least often comprised by URMF (2.9%). Combined HO/RO analysis revealed significant differences in the observed representation of trainees & DC vs expected levels based on total faculty, respectively: WM (33.7% & 60.3% vs. 42.3%), WF (19.2% & 13.9% vs. 22.3%), AM (20.75% & 16.9% vs. 16.4%), AF (17.9% & 2.5% vs. 12.7%), URMM (4.09% & 5.5% vs. 3.5%) and URMF (4.3% & 0.8% vs. 2.8%), P Conclusion Gender & racial/ethnic disparity is present in academic oncology. Specifically, women of all races/ethnicities are proportionally underrepresented in DC positions in HO and RO programs. These data can serve as a benchmark to raise awareness and monitor progress towards a more balanced workforce in oncology.
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- 2021
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7. Evaluating Bias in Speaker Introductions at the American Society for Radiation Oncology Annual Meeting
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Jolie Kantor, C.J. Tsai, Kaitlyn Lapen, Miriam A. Knoll, Christina C. Huang, Narjust Duma, Erin F. Gillespie, Fumiko Chino, and Kanan Shah
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Male ,Cancer Research ,medicine.medical_specialty ,Sexism ,MEDLINE ,Black People ,Demographic data ,Logistic regression ,White People ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Racism ,Sex Factors ,Asian People ,Bias ,Radiation oncology ,Medicine ,Humans ,Names ,Radiology, Nuclear Medicine and imaging ,Societies, Medical ,Retrospective Studies ,Radiation ,Chi-Square Distribution ,business.industry ,Perceived credibility ,Odds ratio ,Hispanic or Latino ,Congresses as Topic ,Confidence interval ,United States ,Cross-Sectional Studies ,Logistic Models ,Oncology ,030220 oncology & carcinogenesis ,Family medicine ,Indians, North American ,Radiation Oncology ,Educational Status ,Female ,business ,Inclusion (education) - Abstract
Introducing a physician without a professional title may reinforce bias in medicine by influencing perceived credibility. We evaluated differences in the use of professional titles in introductions of speakers at recent American Society for Radiation Oncology (ASTRO) Annual Meetings.We reviewed recordings from the 2017 to 2019 ASTRO Annual Meetings and included complete introductions of speakers with a doctoral degree. Professional introduction was defined as "Doctor" or "Professor" followed by the speaker's full or last name. We collected use of professional introduction, introducer gender, speaker gender, and speaker professional and demographic variables. Identified speakers were sent surveys to collect self-reported demographic data. Analysis was performed using χOf 3267 presentations reviewed, 1226 (38%) met the inclusion criteria. Overall, 805 (66%) speakers and 710 (58%) introducers were men. Professional introductions were used in 74% (2017), 71% (2018), and 69% (2019) of the presentations. There was no difference in the use of professional introductions for male and female speakers (71% vs 73%; P = .550). On MVA, male introducers were associated with decreased use of professional address (odds ratio [OR], 0.36; 95% confidence interval [CI], 0.26-0.49; P.001). At the 2019 conference, professional introduction was less likely to be used (2019 vs 2017: OR, 0.68; 95% CI, 0.49-0.96; P = 0.026). Those who self-identified as Asian/Pacific Islander were twice as likely to receive a professional introduction compared with those who identified as white (OR, 1.95; 95% CI, 1.07-3.64; P = .033).Male introducers were significantly less likely to introduce any speaker, regardless of gender, by their professional title, and overall use of professional introductions decreased from 2017 to 2019. Furthermore, no difference in professional introduction use by speaker gender was identified at the recent ASTRO meetings. Implementing speaker guidelines could increase the use of professional introductions and raise awareness of unconscious bias at future ASTRO meetings.
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- 2020
8. Delayed presentations of pediatric solid tumors at a tertiary care hospital in the Bronx due to COVID‐19
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Miriam A. Knoll, David M. Loeb, and Rachel Offenbacher
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2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,SARS-CoV-2 ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Time to treatment ,MEDLINE ,COVID-19 ,Hematology ,Tertiary care hospital ,Time-to-Treatment ,Tertiary Care Centers ,Oncology ,Neoplasms ,Pediatrics, Perinatology and Child Health ,Emergency medicine ,medicine ,Humans ,New York City ,Pediatrics, Perinatology, and Child Health ,Child ,Emergency Service, Hospital ,business - Published
- 2020
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9. The Impact of COVID-19 on Radiation Oncology Clinics and Patients With Cancer in the United States
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Miriam A. Knoll, Evan M. Thomas, Nitin Ohri, Robert C. Miller, and Amanda Rivera
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2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MEDLINE ,Cancer ,COVID-19 ,medicine.disease ,Oncology ,Radiology Nuclear Medicine and imaging ,Family medicine ,Radiation oncology ,medicine ,Radiology, Nuclear Medicine and imaging ,business - Published
- 2020
10. Women's Representation in Leadership Positions in Academic Medical Oncology, Radiation Oncology, and Surgical Oncology Programs
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Miriam A. Knoll, Kirtesh R. Patel, Gaurav Marwaha, Trevor J. Royce, Shikha Jain, Mudit Chowdhary, Neha Vapiwala, Arpit M. Chhabra, Barbara Pro, and Akansha Chowdhary
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Oncology ,Adult ,medicine.medical_specialty ,Faculty, Medical ,education ,Medical Oncology ,Representation (politics) ,Physicians, Women ,Surgical oncology ,Internal medicine ,Radiation oncology ,medicine ,Humans ,Gender disparity ,Academic Medical Centers ,business.industry ,Program director ,General Medicine ,United States ,Leadership ,Cross-Sectional Studies ,Surgical Oncology ,Workforce ,Radiation Oncology ,Female ,Training program ,business - Abstract
Importance Women are underrepresented in medical leadership positions; however, representation of women among academic oncology leadership is unknown. Objectives To evaluate representation of women overall and in leadership positions in academic medical oncology (MO), radiation oncology (RO), and surgical oncology (SO) programs and to examine the association of women leadership with overall faculty representation of women per program. Design, Setting, and Participants In this cross-sectional study, MO, RO, and SO training program websites were queried from October 2018 through June 2019. All faculty from 265 of 273 accredited MO, RO, and SO training programs (97.1%) were included. Exposure Gender. Main Outcomes and Measures Observed proportions of women in leadership positions compared with the expected proportion of overall women faculty in MO, RO, and SO were assessed. Rates of representation of women across each MO, RO, and SO program’s faculty based on the presence or absence of a woman in a leadership position were compared. Results Of 6030 total faculty, only 2164 (35.9%) were women. Total representation of women among MO, RO, and SO faculty was 37.1% (1563 of 4215), 30.7% (389 of 1269), and 38.8% (212 of 546), respectively. Women composed only 21.7% (30 of 138), 11.7% (11 of 94), and 3.8% (1 of 26) of MO, RO, and SO chair positions, respectively. The observed proportion of women in chair positions was significantly lower than the expected proportion for MO, RO, and SO. In all, 47.9%, 33%, and 18.5% of MO, RO, and SO programs, respectively, had at least 1 woman in a leadership position (program director or chair). Programs with 1 or more women in a leadership position were associated with a higher mean (SD) percentage of women faculty than those without at least 1 woman leader in MO (40.7% [12.5%] vs 33.1% [11.0%];P Conclusions and Relevance Gender disparity exists in academic MO, RO, and SO faculty, which is magnified at the chair level. Programs in MO and RO with a woman physician in a leadership position were associated with a higher percentage of women faculty, but this was not true for SO. These data will serve as a benchmark to monitor progress toward a more balanced workforce.
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- 2020
11. Putting Women on the Escalator: How to Address the Ongoing Leadership Disparity in Radiation Oncology
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Reshma Jagsi, Eitan Glucksman, Miriam A. Knoll, and Nancy J. Tarbell
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Male ,Cancer Research ,medicine.medical_specialty ,Radiation ,business.industry ,MEDLINE ,Leadership ,Oncology ,Radiation oncology ,Radiation Oncology ,Humans ,Medicine ,Female ,Radiology, Nuclear Medicine and imaging ,Medical physics ,business ,Societies, Medical - Published
- 2019
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12. Current Social Media Use Among Radiation Oncology Trainees
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Seth T. Lirette, Matthew S. Katz, Raphael Yechieli, Miriam A. Knoll, Jenna M. Kahn, Reshma Jagsi, Ashley Albert, and Naamit K. Gerber
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lcsh:Medical physics. Medical radiology. Nuclear medicine ,Cancer Research ,medicine.medical_specialty ,lcsh:R895-920 ,lcsh:RC254-282 ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Scientific Article ,Radiology, Nuclear Medicine and imaging ,Social media ,Response rate (survey) ,Radiation ,Descriptive statistics ,business.industry ,Professional development ,Odds ratio ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Confidence interval ,Oncology ,030220 oncology & carcinogenesis ,Family medicine ,Professional association ,business ,Career development - Abstract
Purpose: Resident physicians use social media (SM) for many reasons. We sought to characterize current SM use by radiation oncology (RO) trainees for education and professional development. Methods and Materials: An anonymous 40-question survey was sent by e-mail to RO residents in the 2018 to 2019 academic year. SM platform use, time spent on SM, professional use, and opinions regarding SM use were assessed. Descriptive statistics and a univariate logistic regression analysis were performed to identify factors associated with perceptions of SM and spending >25% of SM time for academic or professional purposes. Results: Of the 615 residents surveyed, 149 responded (24% response rate). Facebook (73%), theMednet (62%), Instagram (59%), Twitter (57%), and Doximity (50%) were the top SM platforms used. Most respondents (53%) reported 60 minutes per day over the past week. Residents with an RO mentor on SM (n = 35; 24%; odds ratio [OR]: 2.79; 95% confidence interval [CI], 1.29-6.08; P = .010), those participating in RO discussions on SM (n = 71; 48%; OR: 2.85; 95% CI, 1.42-5.72; P = .003), and those interacting with professional societies (n = 69; 46%; OR: 7.11; 95% CI, 3.32-15.24; P < .001) were more likely to spend >25% of their SM time on professional/academic purposes. The vast majority of respondents agreed that SM exposed them to novel educational content (82%) and was helpful for career development (65%). In addition, 69% agreed that SM can improve clinical skills and knowledge. A substantial minority agreed that SM distracts them from studying (38%) or they felt pressure to have a SM presence (29%). Conclusions: Most RO residents reported that SM provides novel educational content and can help with career development. Potential disadvantages of SM for trainees may include distraction and pressure to maintain a SM presence. SM use by RO trainees merits further research to optimize its potential for education and professional development.
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- 2020
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13. PO-1285: Gender disparity among United States academic oncology program leadership
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Gaurav Marwaha, Trevor J. Royce, S. Jain, Neha Vapiwala, Mudit Chowdhary, Arpit M. Chhabra, Akansha Chowdhary, Kirtesh R. Patel, Miriam A. Knoll, and B. Pro
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medicine.medical_specialty ,Oncology ,Family medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Hematology ,Psychology ,Gender disparity - Published
- 2020
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14. Non-Melanoma Skin Cancers in the Older Patient
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Miriam A. Knoll, Ashley Albert, John A. Conti, and Ross I S Zbar
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Male ,0301 basic medicine ,medicine.medical_specialty ,Skin Neoplasms ,medicine.medical_treatment ,Population ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,medicine ,Humans ,Molecular Targeted Therapy ,Intensive care medicine ,education ,Geriatric Assessment ,Aged ,Randomized Controlled Trials as Topic ,Aged, 80 and over ,education.field_of_study ,Radiotherapy ,business.industry ,Incidence (epidemiology) ,Age Factors ,medicine.disease ,Radiation therapy ,030104 developmental biology ,Clinical Trials, Phase III as Topic ,Oncology ,Geriatric oncology ,030220 oncology & carcinogenesis ,Quality of Life ,Life expectancy ,Female ,Skin cancer ,business ,Non melanoma - Abstract
The incidence of non-melanomatous skin cancer (NMSC) increases with age and there are specific considerations regarding management of NMSC for the older patient population. Here we will review current data regarding treatment considerations and options for older patients with NMSC. Hypofractionated regimens and high-dose brachytherapy may be non-surgical treatment options for older patients with NMSC. Other less aggressive strategies such as active surveillance can also be considered in some settings. Management of NMSC in the older patient population requires a thorough assessment of comorbidities, frailty, and life expectancy. Additionally, discussions regarding goals of care and quality of life (QOL) issues are especially important in this population. Older patients with NMSC in particular may benefit from a tailored treatment plan based on current available data rather than a broad application of general treatment guidelines for NMSC.
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- 2019
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15. Association of Gender and Parenthood With Conference Attendance Among Early Career Oncologists
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Reshma Jagsi, Rochelle D. Jones, Miriam A. Knoll, and Kent A. Griffith
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Cancer Research ,medicine.medical_specialty ,business.industry ,education ,MEDLINE ,Parenthood Status ,Attendance ,Survey research ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,Family medicine ,medicine ,Research Letter ,030212 general & internal medicine ,Early career ,Association (psychology) ,business - Abstract
This survey study evaluates the association of gender and parenthood status with conference attendance among career oncologists.
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- 2019
16. 162: Twitter: A Platform for Dissemination and Discussion of Scientific Papers in Radiation Oncology
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Chirag Shah, Miriam A. Knoll, Guila Delouya, Houda Bahig, Daniel Taussky, Carole Lambert, and Noémie Paradis
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Engineering ,medicine.medical_specialty ,Oncology ,business.industry ,Radiation oncology ,medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Hematology ,business - Published
- 2020
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17. Additional Factors in the Association of Gender and Parenthood With Conference Attendance—Reply
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Reshma Jagsi and Miriam A. Knoll
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Cancer Research ,medicine.medical_specialty ,Oncology ,business.industry ,Surveys and Questionnaires ,Family medicine ,Attendance ,Humans ,Internship and Residency ,Medicine ,business ,Association (psychology) - Published
- 2020
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18. Defining and Shattering the Glass Ceiling in Radiation Oncology
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Miriam A. Knoll
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Cancer Research ,medicine.medical_specialty ,Neurosurgery ,Dermatology ,Medical Oncology ,03 medical and health sciences ,Otolaryngology ,Physicians, Women ,0302 clinical medicine ,Radiation oncology ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical physics ,030212 general & internal medicine ,Surgery, Plastic ,Glass ceiling ,Radiation ,business.industry ,Hematology ,Surgery.plastic ,Career Mobility ,Oncology ,030220 oncology & carcinogenesis ,Radiation Oncology ,Female ,business - Published
- 2017
19. It starts at the top: An analysis of female representation in academic medical oncology (MO), radiation oncology (RO), and surgical oncology (SO) program leadership positions
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Neilayan Sen, Neha Vapiwala, Dian Wang, Kirtesh R. Patel, Parul N. Barry, Trevor J. Royce, Mia Levy, Miriam A. Knoll, Ruta D. Rao, Mudit Chowdhary, Akansha Chowdhary, Shikha Jain, Barbara Pro, and Gaurav Marwaha
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Oncology ,Cancer Research ,medicine.medical_specialty ,Surgical oncology ,business.industry ,Internal medicine ,Radiation oncology ,medicine ,Representation (systemics) ,business ,Academic medicine - Abstract
10520 Background: Female underrepresentation in academic medicine leadership is well-documented; however, oncology specific data are scarce. This study evaluates female leadership representation in academic medical oncology (MO), radiation oncology (RO) and surgical oncology (SO) programs. Furthermore, we examine the impact of female leadership on overall female faculty representation. Methods: A total of 264 (96%) Accreditation Council for Graduate Medical Education actively accredited MO [144 of 153], RO [93 of 94] and SO [27 of 27] training programs were included. The gender of overall faculty and those in leadership positions (program director and departmental chair/division chief) of each program was determined using hospital websites from 10/01/18 to 01/27/19. The chi-squared goodness-of-fit test was used to examine whether the observed proportion of females in leadership positions deviates significantly from the expected proportion based on the actual proportion of overall female faculty in MO, RO and SO. Two-sample t-tests were used to compare rates of female faculty representation across each program based on the presence/absence of female in a leadership position for MO, RO and SO. Results: Female faculty representation in MO, RO and SO was 37.1% (1,554/4,191), 30.7% (389/1,269) and 38.8% (212/546), respectively. Female representation in leadership positions was 31.5% (82/260), 17.4% (31/178) and 11.1% (5/45), respectively. The observed proportion of females in leadership positions was significantly lower than the expected proportion of females in leadership positions for RO (17.4% vs. 30.7%, p = .0001) and SO (11.1% vs. 38.8%, p = .0001), and demonstrated a trend towards significance for MO (31.5% vs. 37.1%, p = .063). 47.9%, 33% and 18.5% of MO, RO and SO programs had ≥1 female in a leadership position, respectively. Programs that had a female in a leadership position had a higher mean percentage of overall female faculty than those that did not: 41.0% vs 35.0% (p = .0006), 36.0% vs 26.0% (p = .0002) and 39.0% vs 32.0% (p = .348) for MO, RO and SO, respectively. Conclusions: Gender disparity exists in academic MO, RO and SO faculty and is magnified at the leadership level. Programs with a female physician in a leadership position are associated with a higher percentage of female faculty.
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- 2019
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20. Focal Radiation Therapy for Cancer
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Reshma Jagsi, Kenneth E. Rosenzweig, and Miriam A. Knoll
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Oncology ,Cancer Research ,medicine.medical_specialty ,Stereotactic body radiation therapy ,business.industry ,Patient Selection ,medicine.medical_treatment ,Treatment outcome ,MEDLINE ,Cancer ,Radiosurgery ,medicine.disease ,Radiation therapy ,Treatment Outcome ,Text mining ,Risk Factors ,Neoplasms ,Internal medicine ,medicine ,Humans ,business - Published
- 2019
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21. Social Media and Gender Equity in Oncology
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Reshma Jagsi and Miriam A. Knoll
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Oncologists ,Cancer Research ,Gender equity ,medicine.medical_specialty ,Attitude of Health Personnel ,business.industry ,Mentors ,Sexism ,Work-Life Balance ,Work–life balance ,MEDLINE ,Career Mobility ,Physicians, Women ,Oncology ,Family medicine ,Humans ,Medicine ,Female ,Social media ,business ,Social Media ,Women, Working - Published
- 2019
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22. Adjuvant radiation for salivary gland malignancies is associated with improved survival: A National Cancer Database analysis
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Ryan Rhome, Miriam A. Knoll, Vishal Gupta, Brett A. Miles, Umut Ozbek, Richard L. Bakst, and William Su
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Oncology ,lcsh:Medical physics. Medical radiology. Nuclear medicine ,medicine.medical_specialty ,lcsh:R895-920 ,Malignancy ,lcsh:RC254-282 ,03 medical and health sciences ,0302 clinical medicine ,Major Salivary Gland ,Internal medicine ,Epidemiology ,medicine ,Radiology, Nuclear Medicine and imaging ,Scientific Article ,030223 otorhinolaryngology ,Salivary gland ,business.industry ,Hazard ratio ,Cancer ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.anatomical_structure ,Salivary gland cancer ,030220 oncology & carcinogenesis ,Cohort ,business - Abstract
Objective There are no randomized data to support the use of postoperative radiation for salivary gland malignancies. This study uses the National Cancer Database (NCDB) to describe the epidemiology of salivary gland cancer patients and to investigate whether treatment with adjuvant radiation improves overall survival. Methods and materials A total of 8243 patients diagnosed with a major salivary gland cancer were identified from the NCDB. All patients received primary surgical resection of their malignancy. Patients were risk-stratified by adverse features, and overall survival rates were determined. Patients were considered high risk if they had extracapsular extension and/or positive margin after resection. Patients were considered intermediate risk if they did not meet the criteria for high risk but had pT3-T4 disease, pN+ disease, lymphovascular space invasion, adenoid cystic histology, or grade 2-3 disease. Patients who did not meet criteria for high or intermediate risk were considered low risk. Overall patient demographics, disease characteristics, treatment factors, and outcomes were summarized with descriptive statistics and analyzed with STATA. Results Median follow-up in this cohort was 42.4 months, with the median age of 58 years. Patients in the high-risk group had greater survival (hazard ratio [HR], 0.76; P = .002; 95% confidence interval [CI], 0.64-0.91) if they received adjuvant radiation therapy. In contrast, patients in the intermediate- (HR, 1.01; P = .904; 95% CI, 0.85-1.20) and low-risk groups (HR, 0.85; P = .427; 95% CI, 0.57-1.26) did not experience a survival benefit with adjuvant radiation therapy. Conclusions This large analysis compared survival outcomes between observation and adjuvant radiation alone in risk-stratified patients after resection of major salivary glands using a national database. The use of adjuvant radiation for high-risk major salivary gland cancers appears to offer a survival benefit. Although an overall survival benefit was not seen in low- and intermediate-risk salivary gland cancers, this study could not address impact on local control because of the limitations of the NCDB.
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- 2016
23. Palliation of Ulcerative Breast Lesions with Radiation
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S Green, Amy Tiersten, Kavita V. Dharmarajan, Miriam A. Knoll, Richard L. Bakst, and Prashant Vempati
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0301 basic medicine ,Oncology ,Adult ,Cancer Research ,medicine.medical_specialty ,Palliative care ,Palliative Radiation Therapy ,Advanced breast ,Breast Neoplasms ,Disease-Free Survival ,Capecitabine ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Quality of life ,Internal medicine ,medicine ,Humans ,Breast ,Radiation Injuries ,Contraindication ,Aged ,Neoplasm Staging ,Systemic chemotherapy ,business.industry ,Palliative Care ,Cancer ,Radiotherapy Dosage ,General Medicine ,Middle Aged ,medicine.disease ,Treatment characteristics ,Surgery ,030104 developmental biology ,Treatment Outcome ,030220 oncology & carcinogenesis ,Cohort ,Toxicity ,Quality of Life ,Female ,Neoplasm Recurrence, Local ,business ,medicine.drug - Abstract
199 Background: Patients with advanced breast cancer may experience ulcerative breast lesions. Breast cancer with ulcerative lesions has been shown to severely affect a patient’s quality of life (QoL). The role of palliative radiation therapy (RT) in the management of ulcerative breast lesions needs to be further explored. Methods: IRB-approval was obtained to retrospectively review the radiation treatment records for all patients who underwent palliative RT for breast cancer at our urban academic medical center. A total of 13 patients were identified, and we herein report their demographics, treatment characteristics, and clinical outcomes. Results: The mean age of the patients receiving palliative RT for ulcerative breast cancer was 64 years. All patients had stage IV disease when they were evaluated for RT. All patients received prior systemic chemotherapy with a mean of four chemotherapeutic agents, the most common of which was Capecitabine. The mean radiation dose received for palliative RT was 27.54 Gy in 11 fractions with a median dose of 30 Gy in 15 fractions. Six (46%) of the patients received prior RT to the same breast, with a median dose of 59.5 Gy in 31 fractions. Among these six patients, the average interval between initial RT and ulcerative breast lesion was 69.5 months. The median overall survival in all patients since ulcerative breast lesion was 5 months and the mean survival did not differ between patients with previous history of RT and RT-naïve patients (4.50 vs. 4.57; p = 0.95). Six out of the 9 (69%) patients who received ≥ 30 Gy reported clinical improvement, whereas none of the 4 patients who received < 30 Gy reported any benefit. There were no radiation-associated toxicities reported by patients. Conclusions: These data suggest that palliative RT ( ≥ 30 Gy) is an efficacious treatment for ulcerative breast cancer with minimal toxicity. Prior RT should not be a contraindication as patients with previous history of RT have similar outcomes compared to RT-naïve patients.
- Published
- 2016
24. Survival of Patients With Multiple Intracranial Metastases Treated With Stereotactic Radiosurgery: Does the Number of Tumors Matter?
- Author
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Andrew I. Yang, Matthew G. Ewend, Ima Paydar, Douglas Kondziolka, Brian T. Collins, Sean P. Collins, Jeremy Steinberger, Eric K. Oermann, and Miriam A. Knoll
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Male ,Cancer Research ,medicine.medical_specialty ,Systemic disease ,Databases, Factual ,medicine.medical_treatment ,Radiosurgery ,03 medical and health sciences ,0302 clinical medicine ,Cyberknife ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Survival rate ,Aged ,Retrospective Studies ,Performance status ,business.industry ,Brain Neoplasms ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Prognosis ,Confidence interval ,Surgery ,Survival Rate ,Oncology ,030220 oncology & carcinogenesis ,Female ,Radiology ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Defining prognostic factors is a crucial initial step for determining the management of patients with brain metastases. Randomized trials assessing radiosurgery have commonly limited inclusion criteria to 1 to 4 brain metastases, in part due to multiple retrospective studies reporting on the number of brain metastases as a prognostic indicator. The present study reports on the survival of patients with 1 to 4 versus ≥5 brain metastases treated with radiosurgery. We evaluated a retrospective multi-institutional database of 1523 brain metastases in 507 patients who were treated with radiosurgery (Gamma Knife or Cyberknife) between 2001 and 2014. A total of 243 patients were included in the analysis. Patients with 1 to 4 brain metastases were compared with patients with ≥5 brain metastases using a standard statistical analysis. Cox hazard regression was used to construct a multivariable model of overall survival (OS). To find covariates that best separate the data at each split, a machine learning technique Chi-squared Automated Interaction Detection tree was utilized. On Pearson correlation, systemic disease status, number of intracranial metastases, and overall burden of disease (number of major involved organ systems) were found to be highly correlated (P
- Published
- 2016
25. MALT Lymphoma of the Bladder: A Case Report and Review of the Literature
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Miriam A. Knoll, Richard L. Bakst, Adriana K. Malone, Mahfood Alqatari, Prashant Vempati, and James A. Strauchen
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Pathology ,medicine.medical_specialty ,business.industry ,lcsh:RC633-647.5 ,Case Report ,MALT lymphoma ,General Medicine ,lcsh:Diseases of the blood and blood-forming organs ,medicine.disease ,Malignancy ,Definitive Radiation Therapy ,Optimal management ,immune system diseases ,Total dose ,hemic and lymphatic diseases ,medicine ,Radiology ,Stage (cooking) ,Early stage disease ,business ,Rare disease - Abstract
The presentation of a MALT lymphoma in the bladder is exceedingly rare. Furthermore, the optimal treatment of primary MALT confined to the bladder remains to be defined. Here, we report a case of a 65-year-old female with primary MALT lymphoma treated with definitive radiation therapy. The patient received a total dose of 30 Gy in 20 equal daily fractions to the bladder and tolerated the treatment well. In addition, we have extensively reviewed the relevant literature to better define the optimal management of this rare disease. In conclusion, primary MALT lymphoma of the bladder represents a rare malignancy with excellent prognosis if detected at an early stage. For early stage disease, definitive radiation represents an excellent treatment modality with a minimal side-effect profile.
- Published
- 2015
26. (P050) Adjuvant Radiation for Salivary Gland Malignancies Is Associated With Improved Survival- an Analysis From the National Cancer Database
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Vishal Gupta, Ryan Rhome, Miriam A. Knoll, Umut Ozbek, William Su, Richard L. Bakst, and Brett A. Miles
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Oncology ,Cancer Research ,Adjuvant radiotherapy ,medicine.medical_specialty ,Radiation ,Salivary gland ,business.industry ,Cancer ,Improved survival ,medicine.disease ,medicine.anatomical_structure ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,business - Published
- 2017
- Full Text
- View/download PDF
27. 673 LONG TERM URINARY AND RECTAL TOLERANCE IN PROSTATE CANCER SURVIVORS TREATED WITH DEFINITIVE CONFORMAL RADIOTHERAPY
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Dahlia Sperling, Xin Pei, Michael J. Zelefsky, and Miriam A. Knoll
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Oncology ,Prostate cancer ,medicine.medical_specialty ,business.industry ,Urology ,Urinary system ,Internal medicine ,medicine ,Conformal radiotherapy ,medicine.disease ,business ,Term (time) - Published
- 2012
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- View/download PDF
28. Long-term urinary and rectal tolerance in prostate cancer survivors treated with definitive conformal radiation therapy
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Xin Pei, Michael J. Zelefsky, and Miriam A. Knoll
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Oncology ,Cancer Research ,medicine.medical_specialty ,Radiation ,business.industry ,Urinary system ,Urology ,Conformal radiation therapy ,medicine.disease ,Term (time) ,Prostate cancer ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,business
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