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Mucormycosis is an opportunistic fungal infection involving among others the paranasal sinuses, nasal fossa and brain parenchyma. Mucor can invade the brain parenchyma by either contiguous spread from the paranasal sinuses or through vascular invasion. We report a case of fatal rhino-cerebral mucormycosis in whom cytotoxic edema at magnetic resonance diffusion-weighted imaging was symmetrically restricted to both neocortical and paleocortical primary areas of olfactory projection at earliest phase of the disease process. Shortly later tissue damage extended into the whole brain. This undescribed observation raised the hypothesis of preferential way of brain invasion by Mucor through the olfactory tract.

Resume De nouveaux medicaments anti-epileptiques sont apparus ces dernieres annees. Les anti-epileptiques demeurent des substances frequemment utilisees lors des tentatives de suicide medicamenteuses. Les donnees recueillies par les centres antipoison nord-americains indiquent que la mortalite et la morbidite demeurent elevees avec les molecules anti-epileptiques de la generation anterieure, en particulier avec l’acide valproique. L’objectif de cette courte revue est de presenter le profil de securite de sept anti-epileptiques recents : topiramate, vigabatrin, tiagabine, gabapentine, levetiracetam, felbamate, lamotrigine et oxcarbazepine. Il decoule des observations isolees ou des rares series publiees que les intoxications aigues par les anti-epileptiques de nouvelles generations s’accompagnent d’une mortalite et d’une morbidite extremement basses. Comme prevu, une depression du systeme nerveux central de courte duree a ete frequemment observee. Cependant, seul un faible nombre de patients a du beneficier d’une ventilation artificielle. Des crises d’epilepsie sont occasionnellement decrites. Une toxicite cardiovasculaire significative n’a ete rapportee a ce jour que dans quelques observations. Le traitement de ces intoxications est essentiellement symptomatique.

A particularly severe case of Guillain-Barré syndrome occurring during pregnancy is reported. The therapeutic approach including plasmapheresis, ventilation, analgesia, sedation, metabolic requirements and heparin therapy is discussed with the consequences on foetal development and the early days of life.

Presents a case study of a massive oral exposure to hexavalent chromium in which there was demonstrable toxic effects seen on the proximal renal tubule that remained limited. Initial treatment of the medical condition; Main manifestations of hexavalent chromium toxicity; Results of the early administration of ascorbic acid and N-acetylcysteine.