Search

Proliferative fasciitis (PF) is a rare pseudosarcomatous lesion arising from the subcutaneous fascia and the fibrous septa. Only few hundred cases have been reported in the literature. In the largest series of 53 patients, only two patients had PF lesion arising from the flank. The most common site of origin is extremities followed by abdomen and head and neck. Its origin from the abdominal wall layer and presentation as the fever has been rarely reported in the literature. A PF lesion larger than 5 cm dimension has been sparsely noted. We report the presence of this rare entity in a 68-year-old gentleman who presented to us with low-grade fever and the presence of large lump arising from the abdominal wall. In our patient, the lesion was arising from transervsalis fascia and was excised in toto laparoscopically without damaging the abdominal muscles. It is imperative to differentiate both these lesions from sarcoma on histopathological examination as the follow-up treatment protocols for both vary.

We report a case of hand soft tissue tumor-proliferative fasciitis (PF)-in a 12-year-old patient that presented as a painful lump causing trigger finger. After meticulous diagnostic workup, a surgical excision led to immediate amelioration of symptoms. PF is a rare benign pseudosarcomatous lesion arising typically in the subcutaneous tissue and fascia in adults. It is very uncommon in the hand. To the best of our knowledge, this is the first report of a trigger finger being caused due to this pathology. In this report, the authors review PF lesions on hands, advice careful evaluation of magnetic resonance imaging features, and recommend surgical management.

Antrochoanal polyps are occasionally encountered in an ear, nose and throat practice and most of them present with progressive unilateral nasal blockage. This paper depicts a pediatric patient’s peculiar presentation of an infected antrochoanal polyp along with obstructive symptoms as the stalk of the antrochoanal polyp which favours proliferative fasciitis could be a possible cause of an acute manifestation of the disease. The stalk, which was adherent to the medial wall of the maxillary sinus and anterior portion of the polyp was removed via intranasal endoscopic approach. Postoperatively, the patient was discharged well and after two years of follow-up, there were no signs of recurrence.

Proliferative fasciitis (PF) is a benign fibroblastic reaction with histological and clinical characteristics that overlap with those of malignant soft tissue tumors; thus, it is referred to as a pseudosarcomatous reaction. It continues to be an important cause of diagnostic error and overtreatment. The childhood PF subtype has some distinct histological and immunohistochemical characteristics that make differential diagnosis with malignant tumors even harder, especially with sarcoma. These proliferations generally occur in the lower limbs, and the periorbital region is a rare location of appearance. Here, we describe a case of childhood subtype PF in a 16-year-old girl located in the periorbital area. To the best of our knowledge, this is the first reported case of childhood subtype PF in the periorbital area, and the third case if PF subtypes are not taken into account.

Of the many benign mimickers of soft tissue sarcoma, proliferative fasciitis is a rare entity which is a diagnostic challenge for pathologist. Recognition of this pseudo sarcoma is very essential as it aids in the appropriate management of the same. Other members of the pseudo sarcoma family are proliferative myositis, nodular fasciitis, inflammatory pseudotumor and proliferative peribursitis. We present 3 cases of proliferative fasciitis which was reported in our hospital in the last 10 years, between 2007 and 2017. Keywords: Pseudosarcoma, Proliferative fasciitis, Rare soft tissue pseudo sarcoma.

Benign myofibroblastic lesions can clinically and histologically be mistaken for sarcoma. Excessive and potentially disfiguring surgical treatment can be avoided by ruling out malignancy. We present the case of a low-grade, myofibroblastic lesion of the lip, which shows how detailed clinical examination rather than reliance on histopathological information alone helped to achieve this. Differential diagnoses of myofibroblastic lesions are also discussed.

Proliferative fasciitis (PF) of the hand is a rare condition, which typically occurs in adulthood. To date, only two dozen cases of PF have been reported in children. This benign condition can mimic malignant soft tissue tumors such as soft tissue sarcoma. We present a case of histopathologically confirmed PF of the fifth right finger in a nine-year-old girl, along with the imaging workup. We also provide a review of the previous literature on PF in children.

Nodular fasciitis is a benign myofibroblastic tumor. Its uncommon variant, proliferative fasciitis (PF), can present in an even less common intradermal form. We report a case of intradermal PF of the ear in a 45-year-old man who presented with recurrent episodes of pain and swelling of the lesion. Histologic examination showed a dermal, nodular proliferation of ganglion-like basophilic fibroblasts with prominent nuclei and nucleoli, admixed with foamy histiocytes and areas of spindle cells arranged in intersecting fascicles in a fibromyxoid background. Lesional cells stained positive for smooth muscle actin and were negative for AE1/AE3, p63, and Melan-A. CD68 highlighted intervening histiocytes. We postulate that the underlying chondrodermatitis nodularis helicis was a triggering etiology, consistent with the current speculation that intradermal PF results from trauma.

Proliferative fasciitis is a pseudo-sarcomatous myofibroblastic proliferation characterized by the presence of unusual giant cells resembling ganglion cells, which usually occurs in the adult population with a mean age of 54 years. It usually affects the upper extremities and is rare in head and neck region with only 11 cases described in the literature so far. Because of rapid growth and histological similarity to various malignant tumors such as rhabdomyosarcoma, recognition of this benign condition is a matter of utmost importance when a pathologist is concerned. In this study, we report a case of a 11-year-old boy presented with a lesion on the right side of chin, along with a literature review involving those cases reported in the head and neck region.

Background Proliferative fasciitis is a benign and reactive lesion involving fibroblasts in the subcutaneous tissues and deep fascia, with a rare occurrence in the head and neck region. It is considered a variant of nodular fasciitis, which could involve trauma as an etiology. Proliferative fasciitis mostly occurs in adults, but cases in children have been reported. Clinically, it can present as an aggressive lesion with pain or no symptoms, mimicking sarcomas. Case Summary We report a case of a 53-year-old woman who presented to our clinic for an evaluation of a reddish lesion of the right mandibular gingiva around the molar areas with a relatively rapid onset. The patient had prediabetes with moderate oral hygiene and no other significant medical history.Intraoral examination revealed a poorly circumscribed gingival lesion on the posterior, Conclusions Because proliferative fasciitis has not been reported in the oral cavity, to our knowledge, and because it poses a diagnostic challenge and can mimic malignancies, it is essential to know the salient diagnostic features to avoid aggressive treatment in patients presenting with such lesions in the oral cavity.

proliferative fasciitis pF is a reactive proliferative soft tissue lesion. ıt is seen only rarely in the head and neck region. pF lesions are mostly small in size but they grow rapidly and can be confused with sarcomatous lesions. a 36-year-old man presented with a swelling in the right neck. on physical examination, about an immobile mass of about 1x1 cm was noted on the right neck. magnetic resonance imaging showed a mass, measuring 16x12 mm. excisional biopsy was performed. The tumor was diagnosed as pF. pF is synonymous with pseudosarcomatous fasciitis that typically manifests as tender solitary lesions measuring less than 3c m. These lesions are most often located on the lower extremities. The pathogenesis of pF is unclear. Trauma is the most common factor in the etiopathology of pF. microscopically, the tumor is composed of ganglion-like cells and giant fibroblast cells. The best treatment option for pF is complete surgical excision of the lesion, reaktif proliferatif yumuşak doku lezyonlarından biri olan proliferatif fasiitis baş-boyun bölgesinde nadir görülür. sıklıkla küçük boyutta olan bu lezyonlar hızlı büyüme gösterdikleri için sarkomatöz lezyonlar ile karışabilirler. otuz altı yaşında erkek hasta, boyunda şişlik şikayeti ile başvurdu. Fizik muayenesinde boyun sağ lateralinde yaklaşık 1x1cm boyutunda sert, immobil kitlesel lezyon palpe edildi. Yapılan manyetik rezonans görüntülemesinde kontrast enhansmanı gösteren 16x12mm boyutlarında kitlesel lezyon izlendi. Yapılan eksizyonel biyopsi sonucu histopatolojik inceleme proliferatif fasiitis olarak raporlandı. lezyon tamamen çıkarıldığı için başka bir tedaviye gerek duyulmadı. proliferatif fasiitis, proliferatif myozitis ve nodüler fasiitis ile birlikte psödosarkomatöz fibroblastik proliferasyonları oluştururlar. hızlı büyüme göstermelerine rağmen, çok büyük boyutlara ulaşmazlar. etyolojisi tam olarak bilinmemekle birlikte travma suçlanan nedenler arasındadır. Bu lezyonlara en sık alt ekstremitelerde rastlanır. mikroskobik olarak iğsi, iki nükleuslu, dev fibroblast benzeri ve ganglion benzeri hücreler görülür. Klinik olarak çok benzerlik gösterdikleri için malign mezenkimal tümörler ile ayırıcı tanıları mutlaka yapılmalıdır. Tedavisinde lezyonun total eksizyonu yeterli olmaktadır

Intradermal nodular fasciitis is a rare but not extraordinary pathological finding with approximately 100 cases reported since originally described in 1990. Intradermal proliferative fasciitis, however, has only been reported twice and both arose in the postauricular region. Herein, we report a third case of intradermal proliferative fasciitis and the first to occur on the finger. This case was also unusual in its slow growth, and complete lack of smooth muscle actin expression that has only been reported once before.

Proliferative Fasciitis (PF) is a benign lesion with histologic and clinical features overlapping with those of malignant soft tissue tumours. Its occurrence in children is considered very rare. We present a case of PF appearing as a painful, red, gradually increasing in size lesion, during a period of a few weeks, on the finger of a five-year-old boy compromising the dermis and subcutaneous tissue. We were able to locate literature on 20 paediatric PF cases, which we review. Only five of these focus on the clinical data, the rest describing mainly histological findings. It is the first reported paediatric case appearing on the finger.

Proliferative fasciitis is a benign lesion that usually has a self-limited course and rarely recurs after excision. In the literature, the multifocal occurrence of PF in different anatomic sites has not been reported so far. In this report, we describe the clinical case of a 30-year-old woman with two metachronous proliferative fasciitis occurring firstly in the orbit and, after 18 months, in the forearm; we also review the available literature on this topic, outlining guidelines for therapy and the follow-up of these patients.

Proliferative fasciitis is a rare entity in the orbit. A 16-year-old boy presented with a growing right orbital mass, which was palpable just inferior to the medial right eyebrow. MRI demonstrated a 12 × 8 × 9 mm mass located medial to and slightly above the right globe within the subcutaneous soft tissues. An anterior orbitotomy with debulking of the lesion was performed. Histopathological examination confirmed a diagnosis of proliferative fasciitis. To the authors' knowledge, there is only one prior case in the literature demonstrating proliferative fasciitis of the orbit.

Proliferative fasciitis (PF) is a pseudosarcomatous proliferation which typically occurs in the subcutaneous tissue and fascia. Although patients are characteristically middle-aged people, occasionally PF can arise in children. Histologically, PF is characterized by a proliferation of large ganglion-like and spindle-shaped cells which, especially in childhood, may exhibit high mitotic activity, but no atypical mitoses. We report a case of PF in the dermis of a 13-year-old boy. This is the first case of PF primarily arising in the dermis. Apart from the unusual site, another intriguing finding was the presence of rare atypical mitoses, a feature which has not been previously emphasized in PF. Awareness that PF may occur in the dermis, exhibiting occasional atypical mitoses, is crucial to avoid a misdiagnosis of malignancy.

稀な増殖性筋膜炎の後腹膜腔発生例を経験したので本邦報告例の集計とともに報告する.症例は51歳,男性.右下腹部の無痛性の腫瘤を主訴に当院を受診し, CTにて右腸腰筋に接し,盲腸を圧排する9cm大の後腹膜腔腫瘤が認められた.後腹膜腔原発の悪性腫瘍を疑い,開腹手術となった.腫瘍は11cm径に増大して尿管を巻き込むように存在し,腸腰筋への浸潤を認め,右尿管切除に伴う腫瘍摘出術を施行した.病理組織学的に腫瘍は良性疾患である増殖性筋膜炎と診断された.本症はganglion-like cellの出現を特徴とする良性疾患で四肢への発生例が多く,自然消退例の報告もみられる.しかし本症のような後腹膜腔発生例は極めて稀であり,興味深い症例と考えられた.

Proliferative myositis (PM) along with proliferative fasciitis and nodular fasciitis are a group of pseudosarcomatous myofibroblastic proliferations. Although the histologic presentation of each is almost identical, the magnetic resonance imaging (MRI) appearance of proliferative myositis is closer to that of inflammatory myopathies. We report a case of PM in which the imaging and histologic features combine typical findings of PM with unusual imaging features, suggesting of reactive (or nodular) fasciitis.

During ultrastructural examination of a difficult to diagnose tumor, short spacing collagen fibrils (periodicity of banding, approximately 43.2 nm) and native collagen fibrils (periodicity of banding, approximately 53 nm) were found in dilated and vacuolated cisternae of rough endoplasmic reticulum and the perinuclear cistern. Original diagnoses from several histopathologists included alveolar soft part sarcoma, malignant fibrous histiocytoma, atypical fibroxanthoma, and myogenic tumor. The finding of intracisternal collagen (which is but a variety of intracellular collagen) led to the conclusion that this was a fibroblastic neoplasm. This, plus a review of the histologic findings, led to the diagnosis of proliferative fasciitis and myositis of childhood.

We report trisomy 2 as the sole clonal karyotypic abnormality in a case of proliferative fasciitis. To our knowledge, this is the first cytogenetic report of proliferative fasciitis.

Eleven cases of proliferative fasciitis and myositis in children, ages 2.5 months to 13 years, are presented. Eight lesions averaging 2.3 cm in size occurred in the extremities, two in the head and neck region and one on the chest wall. Like proliferative fasciitis and myositis in adults, these lesions consisted of admixtures of large polygonal to spindled, ganglion-cell-like fibroblasts with vesicular nuclei and prominent inclusion-like nucleoli. Seven of 11 lesions were initially diagnosed as sarcomas, most commonly rhabdomyosarcoma. Four patients were treated by wide excision (three with regional lymphadenectomy), three received chemotherapy, and one was given radiation therapy. There were some histologic differences from adult-type proliferative fasciitis and myositis. The childhood lesions were generally well circumscribed, lobulated, extremely cellular with less collagen production, and often associated with acute inflammation and microscopic foci of necrosis. Immunohistochemical comparison with adult proliferative fasciitis and myositis showed similar immuneprofiles; the ganglion-like cells stained for vimentin and actin and focally with KP1, suggesting myofibroblastic and histiocytic features. None of the lesions stained for keratin, desmin, or S-100 protein. Ultrastructural examination of two cases revealed cells with a constellation of fibroblastic, myofibroblastic, and histiocytic features. Follow-up of seven patients, averaging 58 months from diagnosis, confirmed that all are alive and well. Recognition of this cellular variant of proliferative fasciitis and myositis is important to prevent misdiagnosis as a sarcoma and unnecessary, excessive therapy.

This is a report of a 43-year-old man with nodular fasciitis of the little finger. Nodular fasciitis with its feature of rapid growth and aggressive histological appearance is often mistaken for a malignant neoplasm and rarely involves fingers.

A case of proliferative fasciitis in the forearm of a 7-year-old child is presented. The lesion is composed of spindle cells and large bizarre ganglionlike cells in a collagenous matrix with some myxoid areas. The cells contain intracytoplasmic inclusions of collagen. The cytoplasm stains for vimentin, and the cells have ultrastructural features of myofibroblasts. This is the second case reported of proliferative fasciitis occurring in a child, and the importance of distinguishing this lesion from childhood neoplasms with a similar appearance is discussed.

Proliferative myositis and proliferative fasciitis are benign lesions that are often misdiagnosed as sarcomas, leading to unnecessary mutilating surgery and chemotherapy. We report two such initially misdiagnosed cases. Key words: Clinical features; immunohistochemistry; histology DOI: 10.4038/cmj.v50i4.1412 Ceylon Medical Journal Vol.50(4) 2005: 169-170

Nodular fasciitis is a benign, reactive, subcutaneous fibroblastic tumour, which usually presents as a rapidly growing lesion with occasional involvement of the deep fascia and muscle. Unfortunately, nodular fasciitis may be histologically confused with a malignant neoplasm such as malignant fibrous histiocytoma or fibrosarcoma. Although commonly found in the arm and thorax, the hand is rarely involved. The terminology of nodular fasciitis presenting in the hand is confusing. The diagnosis of pseudosarcomatous fasciitis, proliferative fasciitis, and parosteal fasciitis are some of the terms found in the few extant reports. –3 When nodular fasciitis demonstrates the direct association with bone, it is appropriately termed as parosteal fasciitis. We report the radiological and pathological features of a case of parosteal fasciitis of the hand.

Nodular fascitis is a benign fibroblastic tumour characterized by rapid growth and most of the time requires its differentiation from other tumorous lesions. Here is a case of 45 year old male who presented with a soft tissue swelling in the popliteal region. On FNAC, a differential diagnosis of proliferative myositis and proliferative fasciitis was given. Histopathological examination gave a diagnosis of nodular fascitis. Hence cytology helps to give a definite diagnosis and aid in the surgical management of soft tissue tumors.

These are hyperplastic, self-limiting processes, whose cellularity, cell features, and sometimes permeative growth pattern may mimic a sarcoma. They are somehow similar to “myositis ossificans”, except that they do not produce bone. For this reasons, Angervall proposed the term “pseudosarcomatous proliferative lesion of soft tissues without bone formation”.

Nodular fasciitis is characterized by a proliferation of spindle cells which may be misdiagnosed as sarcomas due to the rich cellularity, mitotic activity and variant morphologic patterns.This report includes 42 cases of nodular fasciitis and related conditions of skin and soft tissue from the pathology files of the Royal Brisbane Hospital, Queensland, Australia. There were 33 cases of nodular fasciitis, three cases of ossifying fasciitis, three cases of proliferative fasciitis, two cases of proliferative myositis and one case of intravascular fasciitis. Two-thirds of cases were referred from outside Royal Brisbane Hospital.Nodular fasciitis and ossifying occurred most commonly in young adults with 16 patients (44%) between the ages of 20 and 29. However, the other variants of nodular fasciitis including proliferative myositis and intravascular fasciitis occurred in older people (six patients being older than 49 years) and more commonly occurring in men (n=5). A painless rapidly growing mass was most common. The lesions of nodular fasciitis were most often located in the upper extremity with the forearm most commonly affected.Nodular fasciitis and related conditions are benign. All patients are alive and well 3 months to 13 years (mean 7.2 years) after simple local resection.

Pseudosarcomatous lesions are reactive proliferative lesions of the soft tissue, that are likely to be misdiagnosed as malignant, based on clinical and histological features. The most common lesions are nodular fasciitis, proliferative fasciitis, proliferative myositis and myositis ossificans. These rapidly growing soft-tissue lesions can represent a variety of diagnoses involving radically different treatment modalities. Accurate diagnosis is important to avoid unnecessary and often mutilating surgery. We report two cases to illustrate the importance of correct identification of these lesions by fine needle aspiration cytology.

This is the first report of proliferative fasciitis presenting in a finger. This is a benign pseudo-sarcomatous lesion which normally runs a self-limiting course.

These terms indicate nodular lesions whose anatomo-clinical presentation and nature are similar to that of nodular fasciitis (Fig. 855).

Proliferative fasciitis is unusual in the hand and is particularly unusual in young children. The histology of this benign process can be confusing, and it must be differentiated from a sarcoma. The proper treatment is local excision.