69 results on '"Ugo, Bottoni"'
Search Results
2. Ablative fractional laser improves treatment of actinic keratoses with Ingenol Mebutate
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Mario Sannino, Federica Tamburi, Ester Del Duca, Steven Paul Nistico, Giovanni Cannarozzo, and Ugo Bottoni
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medicine.medical_specialty ,business.industry ,Laser treatment ,lcsh:R ,Immunology ,Fractional laser ,Actinic keratosis ,Ingenol mebutate ,lcsh:Medicine ,Actinic keratoses ,medicine.disease ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,chemistry ,030220 oncology & carcinogenesis ,Ablative case ,Immunology and Allergy ,Medicine ,business - Abstract
Actinic keratoses (AK) are pre-neoplastic lesions related to an excessive ultraviolet exposure that represent an emerging issue in the area of skin diseases which undergo high risk for developing squamous cell carcinoma (SCC). In this open study, we tested the safety efficacy profile of sequential ablative laser and Ingenol Mebutate gel (IngMeb). Thirteen patients with a total of 99 lesions were selected for this open study. When multiple lesions on the same area were found, the treatment area was split in half. In one group, fractional CO2 laser microablative treatment was performed the day before three daily applications of IngMeb 150 lg/g; the other group received IngMeb without previous laser ablation. Fifty-six lesions were treated with laser and IngMeb and a total of 43 lesions in the second group were treated with IngMeb alone. Results at the 12-week follow-up visit showed that a clearance rate of 50/56 (89.2%) had been achieved. On the side that was not pre-treated with laser, 31 out of 43 lesions were cleared (72.1%). In our opinion, ablative fractional laser treatment could improve topical treatment of AKs, or provide a further therapeutic option for resistant patients.
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- 2016
3. Prognostic correlation between vitamin D serological levels, Body Mass Index and clinical-pathological features in melanoma patients
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Stefano Calvieri, Ugo Bottoni, Nicola Veronese, Elisa Moliterni, Dario Didona, Giovanni Paolino, Michele Cardone, Paola Corsetti, Teresa Lopez, Moliterni, E., Paolino, G., Veronese, N., Bottoni, U., Corsetti, P., Cardone, M., Didona, D., Lopez, T., and Calvieri, S.
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Male ,0301 basic medicine ,medicine.medical_specialty ,Skin Neoplasms ,Dermatology ,Gastroenterology ,Body Mass Index ,Serology ,Correlation ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Internal medicine ,Vitamin D and neurology ,Humans ,Medicine ,Vitamin D ,Melanoma ,Pathological ,melanoma ,vitamin D ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,030104 developmental biology ,030220 oncology & carcinogenesis ,Female ,business ,Body mass index - Published
- 2018
4. AB0938 Treatment patterns in early psoriatic arthritis according to the age of onset
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G. Tramontano, Ugo Bottoni, M. Gilio, Salvatore D'Angelo, and Angela Padula
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medicine.medical_specialty ,Psoriatic arthritis ,business.industry ,Medicine ,Age of onset ,business ,medicine.disease ,Dermatology - Published
- 2018
5. Superhydrophobic lab-on-chip measures secretome protonation state and provides a personalized risk assessment of sporadic tumour
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S. Bonacci, Ivan Presta, Rosario Sacco, Elisabetta Ferraro, Nicola Coppedè, M. Greco, Natalia Malara, Ugo Bottoni, Domenica Scumaci, Giuseppe Donato, Gianni Cuda, Roksana Majewska, Volpentesta G, Francesco Gentile, A. Donato, Valentina Trunzo, Giusy Guzzi, Nadia Innaro, Domenico Augusto Francesco Maisano, Valentina Onesto, A. Castellini, C. K. Pirrone, P. Candeloro, Chiara Mignogna, Gerardo Perozziello, Francesco Amato, F. Casale, Maria Laura Coluccio, F. Givigliano, Lorenzo Ferrara, C. Voci, M. Renne, E. Di Fabrizio, Vincenzo Mollace, Marco Giannetto, Giuseppe Sena, Angelo Lavano, Elisabetta Scali, Maria Careri, Malara, N., Gentile, F., Coppedè, N., Coluccio, M. L., Candeloro, P., Perozziello, G., Ferrara, L., Giannetto, M., Careri, M., Castellini, A., Mignogna, C., Presta, I., Pirrone, C. K., Maisano, D., Donato, A., Donato, G., Greco, M., Scumaci, D., Cuda, G., Casale, F., Ferraro, E., Bonacci, S., Trunzo, V., Mollace, V., Onesto, V., Majewska, R., Amato, F., Renne, M., Innaro, N., Sena, G., Sacco, R., Givigliano, F., Voci, C., Volpentesta, G., Guzzi, G., Lavano, A., Scali, E., Bottoni, U., and Di Fabrizio, E.
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0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,tumor early detection ,lab-on-a-chip ,business.industry ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Cancer Early Detection ,lcsh:RC254-282 ,Article ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Text mining ,030220 oncology & carcinogenesis ,Internal medicine ,oect ,medicine ,False positive paradox ,Cancer risk ,business ,Risk assessment ,Sporadic cancer - Abstract
Secretome of primary cultures is an accessible source of biological markers compared to more complex and less decipherable mixtures such as serum or plasma. The protonation state (PS) of secretome reflects the metabolism of cells and can be used for cancer early detection. Here, we demonstrate a superhydrophobic organic electrochemical device that measures PS in a drop of secretome derived from liquid biopsies. Using data from the sensor and principal component analysis (PCA), we developed algorithms able to efficiently discriminate tumour patients from non-tumour patients. We then validated the results using mass spectrometry and biochemical analysis of samples. For the 36 patients across three independent cohorts, the method identified tumour patients with high sensitivity and identification as high as 100% (no false positives) with declared subjects at-risk, for sporadic cancer onset, by intermediate values of PS. This assay could impact on cancer risk management, individual’s diagnosis and/or help clarify risk in healthy populations., Diagnostics: Proton state of secreted proteins in blood helps identify cancer A blood test that measures whether molecules secreted by cells contain titratable proton atoms can accurately discriminate between patients who have cancer and those who don’t. Titratable species may in turn influence the protonation state of a solution, i.e. the number of protons added to and the net charge of that solution. A team led by Natalia Malara from University Magna Graecia in Catanzaro, Italy and Enzo Di Fabrizio from the King Abdullah University of Science and Technology in Thuwal, Saudi Arabia, Francesco Gentile from the University Federico II in Naples, Italy, and Nicola Coppedè from the Institute of Materials for Electronics and Magnetism in Parma, Italy, created an eletrochemical device that can detect faulty metabolism by quantifying the proportion of secreted proteins with and without extra protons—an indicator of abnormal cell division, proliferation and invasion. The researchers tested the device on blood samples from patients with solid tumors and healthy controls. The method identified cancer patients with a high degree of accuracy. If the findings are confirmed in larger trials, the test could help with the screening, diagnosis and management of cancer.
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- 2018
6. Dermatofibrosarcoma protuberans: when the age makes the difference
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Antonio Giovanni Richetta, Giovanni Paolino, Paola Corsetti, Stefano Calvieri, Ugo Bottoni, Federico Romaniello, and Dario Didona
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Adult ,Male ,medicine.medical_specialty ,Disease free survival ,Skin Neoplasms ,Disease-free survival ,Dermatofibrosarcoma ,Neoplasms ,Retrospective studies ,2708 ,Kaplan-Meier Estimate ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Statistical significance ,medicine ,Overall survival ,Dermatofibrosarcoma protuberans ,Humans ,Survival rate ,Aged ,business.industry ,Age Factors ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Primary tumor ,Survival Rate ,Infectious Diseases ,Italy ,030220 oncology & carcinogenesis ,Female ,business - Abstract
BACKGROUND Dermatofibrosarcoma protuberans is a malignant tumor that affects exclusively the skin. It is a low-grade malignant tumor of subcutaneous tissues, characterized by a local recurrence but it seldom metastasizes. This study aimed to evaluate the impact of different clinical parameters on disease free survival and overall survival of dermatofibrosarcoma protuberans patients. METHODS A retrospective study of data including seventeen cases of dermatofibrosarcoma protuberans (eleven male, six female) retrieved from the files of the Dermatology Clinics of La Sapienza University, Rome. We evaluated three clinical parameters (age, sex and anatomic site of the primary tumor) using the Kaplan-Meier product and the Log-Rank Test. RESULTS The results highlighted that patients with an age ≤49 years showed a median disease free survival of 36 months, while patients with an age ≥50 years of 4 months (P
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- 2018
7. PS7:137 The use of belimumab in recalcitrant cutaneous lupus: a case report
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T Carbone, M. Gilio, Ugo Bottoni, A Padula, Salvatore D'Angelo, Cutro, G. Tramontano, and V Picerno
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Skin manifestations ,medicine.medical_specialty ,Leukopenia ,business.industry ,Disease ,Dermatology ,Belimumab ,Refractory ,immune system diseases ,medicine ,Outpatient clinic ,medicine.symptom ,skin and connective tissue diseases ,Malar rash ,business ,Cutaneous lupus ,medicine.drug - Abstract
Background The anti-BAFF monoclonal antibody, belimumab, was approved about five years ago by the US Food and Drug Administration for the treatment of adult SLE patients. The utility of belimumab for management of resistant systemic lupus erythematosus (SLE) has been demostrated but concerning skin manifestations only scarce evidences have been reported. We describe our experience of using this new drug for the successful management of recalcitrant cutaneous lupus. Case report A 38-year-old man with a five year history of SLE presented, in May 2017, at our outpatient clinic for a disease flare with severe cutaneous involvement. On examination the patient presented malar rash and erythematous-infiltrated discoid lesions in the region of head and neck and erythematosus papules also on the extensor surface of the hands. Additional tests showed also systemic involvement by detecting low levels of C3 and C4, leukopenia (WBC 3000/µL) and positivity of ANA (1:1280 by IFI) and anti-dsDNA (42.8 UI/ml by ELISA, nv Conclusion In this case report, the addition of belimumab to steroid monotherapy, in patient who failed previous immunosuppressive treatment improved the signs and symptoms of refractory cutaneous lupus. This report highlights the utility of belimumab for the treatment of severe skin involvement in SLE refractory to conventional therapies. Additional studies should be performed to assess the use of belimumab in the treatment of cutaneous lupus.
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- 2018
8. Carbamazepine-induced necrotizing leukocytoclastic vasculitis with a 20-year latency
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Flavia Pigliacelli, Andrea D 'arino, Giulia Pranteda, Ugo Bottoni, Guglielmo Pranteda, and Gian L Rampioni-Vinciguerra
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medicine.medical_specialty ,Infectious Diseases ,business.industry ,Leukocytoclastic vasculitis ,Medicine ,Dermatology ,Carbamazepine ,Latency (engineering) ,business ,Vasculitis ,medicine.disease ,medicine.drug - Published
- 2018
9. Cost-efficacy analysis of 3% diclofenac sodium, ingenol mebutate, and 3.75% imiquimod in the treatment of actinic keratosis
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Ugo Bottoni, Carolina Muscoli, Steven Paul Nisticò, Micaela Gliozzi, Ester Del Duca, and Valeria Torchia
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medicine.medical_specialty ,Ingenol Mebutate Gel ,Diclofenac ,Cost-Benefit Analysis ,Drug Compounding ,Immunology ,Ingenol mebutate ,Imiquimod ,diclofenac gel ,030207 dermatology & venereal diseases ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Adjuvants, Immunologic ,medicine ,actinic keratosis ,Immunology and Allergy ,Humans ,Multicenter Studies as Topic ,030212 general & internal medicine ,Letter to the Editor ,Randomized Controlled Trials as Topic ,Pharmacology ,pharmacoeconomy ,Epidermis (botany) ,business.industry ,Actinic keratosis ,Anti-Inflammatory Agents, Non-Steroidal ,Decision Trees ,Diclofenac Sodium ,Cost efficacy ,medicine.disease ,Dermatology ,Keratosis, Actinic ,dermatology ,Treatment Outcome ,chemistry ,Clinical Trials, Phase III as Topic ,Aminoquinolines ,Diterpenes ,business ,medicine.drug - Abstract
Actinic keratosis (AK) is a clinical condition characterized by keratinocytic dysplastic lesions of the epidermis, affecting individuals chronically exposed to sunlight. Topical therapies allow the treatment of a whole area of affected skin and currently include diclofenac sodium gel, 5-fluorouracil cream, 5-fluorouracil and acetylsalicylic acid solution, imiquimod cream, and ingenol mebutate gel. Due to the comparable efficacy of 3% diclofenac, ingenol mebutate, and 3.75% imiquimod in treating AK multiple lesions, a pharmacoeconomic evaluation of cost-effectiveness of the three treatments was needed. A cost-efficacy analysis comparing 3% diclofenac sodium with ingenol mebutate and 3.75% imiquimod was performed. In this analysis, efficacy data were combined with quality-of-life measurement derived from previous studies as well as the costs associated with the management of these lesions in Italy. Patients’ demographics and clinical characteristics were assumed to reflect those from the clinical studies considered.
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- 2018
10. Scleroderma with an update about clinico-pathological correlation
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Caterina Ferreli, Ugo Bottoni, Franco Rongioletti, Giuseppe Soda, Laura Atzori, Rongioletti, Franco, Ferreli, Caterina, Atzori, Laura, Bottoni, Ugo, and Soda, Giuseppe
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0301 basic medicine ,medicine.medical_specialty ,Biopsy ,Dermatology ,Skin Diseases ,Scleroderma ,Diagnosis, Differential ,03 medical and health sciences ,Scleroderma, Localized ,0302 clinical medicine ,Scleromyxedema ,Medicine ,Humans ,skin and connective tissue diseases ,Localized Scleroderma ,Scleroderma, Systemic ,integumentary system ,medicine.diagnostic_test ,business.industry ,medicine.disease ,030104 developmental biology ,Infectious Diseases ,Nephrogenic systemic fibrosis ,Skin biopsy ,Scleredema ,scleroderma, systemic ,scleroderma, localized ,pathology ,Cytokines ,business ,030217 neurology & neurosurgery ,Morphea ,Rheumatism - Abstract
Scleroderma is divided into a systemic form called systemic sclerosis and a localized form also called morphea. According to 2013 ACR/EULAR Classification Criteria for Systemic Sclerosis, developed by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR), skin thickening of the fingers extending proximal to the metacarpophalangeal joints is sufficient for a patient to be classified as having scleroderma. Histological examination is not included in the diagnostic criteria and is not routinely performed. Skin biopsy is recommended only in the case of diagnostic doubt with other scleroderma like disorders (scleromyxedema, scleredema, nephrogenic systemic fibrosis). Alternatively, skin biopsy is also often performed for research purposes. Indeed, the first step analysis of new cytokines or pathways that may contribute to the pathogenesis of the disease requires the evaluation of their expression or activation in the skin of scleroderma patients compared to healthy controls. The histological picture of the skin in bot localized and systemic scleroder shows initially microvascular alterations and chronic inflammation while in the more advanced stages skin fibrosis prevails. Localized scleroderma (LS) or morphea includes a number of subtypes which are classified more according to their clinical presentation rather than histopathological pictures. However, some histopathologic changes may be useful in differentiating each entity from the others and from other sclerodermoid disorders.
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- 2018
11. Melanoma in female patients: general features and focus on the impact of estro-progestinic pills in prognostic factors
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Ugo Bottoni, Giovanni Paolino, Teresa Lopez, Diego Abbenante, Dario Didona, Paola Corsetti, Elisa Moliterni, and Stefano Calvieri
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Adult ,Oncology ,medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,melanoma ,female ,estro-progestinic ,Dermatology ,Contraceptives, Oral, Hormonal ,Young Adult ,Internal medicine ,Female patient ,medicine ,Humans ,Melanoma ,Focus (computing) ,business.industry ,Estrogens ,Middle Aged ,Prognosis ,medicine.disease ,Infectious Diseases ,Pill ,Female ,Progestins ,business - Published
- 2018
12. Prognostic factors in head and neck melanoma according to facial aesthetic units
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Dario Didona, Michele Cardone, Giovanni Paolino, Paola Corsetti, Teresa Lopez, Elisa Moliterni, Stefano Calvieri, Ugo Bottoni, Giusy Schipani, and Luigi Losco
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Oncology ,Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,diagnosis ,Dermatology ,Kaplan-Meier Estimate ,melanoma ,facial ,aesthetic ,units ,Malignancy ,Disease-Free Survival ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Head and neck ,Melanoma ,Survival analysis ,Aged ,Retrospective Studies ,Aged, 80 and over ,Scalp ,business.industry ,Incidence (epidemiology) ,Facial neoplasms ,Prognosis ,Retrospective studies ,Surgery ,Middle Aged ,medicine.disease ,Predictive value ,medicine.anatomical_structure ,Head and Neck Neoplasms ,Clinicopathological features ,Female ,Neoplasm Recurrence, Local ,business - Abstract
Background Head and neck melanoma is a clinical challenge. Indeed, cutaneous head and neck melanoma shows a worse prognosis in comparison to melanomas of other body sites. Although the emphasis on facial cosmetic preservation plays a pivotal role in comparison to other body areas, specific Facial Aesthetic Units (FAU) could also play a key role in the prognostic evaluation of the malignancy. Methods The aim of the current study was to evaluate the general outcome and clinicopathological features of head and neck melanoma and to detect prognostic differences according to each FAU. The Kaplan-Meier product was used to calculate survival curves, while Cox proportional-hazard regression was performed to evaluate the predictive value of each FAU. Results A total of 221 head and neck melanoma patients was included in our analysis. In the nasal FAU, we found a high rate of local recurrence, which affected significantly disease-free survival. The worse prognosis was observed in melanoma of the scalp, which showed a greater tendency to skip metastases in internal organs. Moreover, we found that scalp showed a low incidence of non-melanoma skin cancers, if compared to other FAU, highlighting that the scalp local milieu might play a more prominent role in melanoma biology than chronic UV exposition. Conclusions Although FAUs have an aesthetic function, they could also play a role in the evaluation and follow-up of melanoma.
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- 2017
13. AN UNUSUAL CASE OF NEONATAL MASTOCYTOMA
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Giulia di Silvio, Flavia Pigliacelli, Ugo Bottoni, Marta Muscianese, Francesca Magri, Guglielmo Pranteda, Giulia Pranteda, and Andrea D'Arino
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Pathology ,medicine.medical_specialty ,Unusual case ,business.industry ,medicine ,Mastocytoma ,General Medicine ,medicine.disease ,business - Published
- 2017
14. Vitamin D receptor immunohistochemistry variability in sun-exposed and non-sun-exposed melanomas
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Carlo Cota, Dario Didona, Elisa Moliterni, Chiara Panetta, Pietro Donati, Cinzia Di Mattia, Gaetano De Vita, Giovanni Paolino, Stefano Calvieri, and Ugo Bottoni
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Male ,Cancer Research ,Pathology ,Skin Neoplasms ,vitamin D ,Calcitriol receptor ,030207 dermatology & venereal diseases ,0302 clinical medicine ,Buttocks ,Aged, 80 and over ,Vulvar Neoplasms ,Melanoma ,Torso ,Middle Aged ,medicine.anatomical_structure ,Oncology ,Lower Extremity ,030220 oncology & carcinogenesis ,immunohistochemistry ,Scrotum ,Sunlight ,Immunohistochemistry ,Female ,Adult ,medicine.medical_specialty ,Dermatology ,ultraviolet rays ,Malignancy ,Foot Diseases ,Upper Extremity ,03 medical and health sciences ,medicine ,melanoma ,Humans ,vitamin D receptor ,Penile Neoplasms ,Aged ,Scalp ,business.industry ,medicine.disease ,Hand ,Trunk ,Receptors, Calcitriol ,Facial Neoplasms ,business ,Neck - Abstract
Ultraviolet rays are one of the leading factors in the development of melanoma (MM); however, ultraviolet rays seem not to play a role in non-sun-exposed MM, where systemic immunosuppression, anatomical, and physiological features may contribute toward the development of the malignancy. Our aim was to evaluate vitamin D receptor (VDR) expression in shield-site melanoma (ST-MM) and non-shield-site melanoma (NST-MM) to find features that could explain the different biological behavior of MM according to the area of onset. We reviewed 118 specimens of MM. VDR expression was assayed using immunohistochemistry by dividing the specimens according to the anatomical area. We included MM of the soles, feet, hands, gluteus, scrotum, skin of the penile shaft, and large vaginal labia in the ST-MM group. The NST-MM group was divided into two main categories: NST-MM of chronic sun-exposed areas, including MM of the face, scalp, neck, back of the hands, and NST-MM of intermittent sun-exposed areas, including MM of the trunk, lower, and upper limbs. In shield sites, 66.67% of MMs showed VDR expression; in intermittent sun-exposed areas, 33.3% showed VDR expression; and in chronic sun-exposed areas, only 4.66% showed VDR expression. A similar behavior was observed for Breslow's thickness, where VDR staining intensity was higher in thicker lesions, ranging between 60 and 100%. We found that VDR expression decreased from ST-MM to NST-MM. These findings confirm the hypothesis that different pathways are involved in ST-MM and NST-MM.
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- 2017
15. Superiority of a vitamin B12-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis
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Ugo Bottoni, Francesca Farnetani, Ester Del Duca, Steven Paul Nisticò, Giovanni Pellacani, and Nathalie De Carvalho
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Adult ,Male ,medicine.medical_specialty ,Immunology ,Treatment outcome ,Population ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Psoriasis ,Humans ,Immunology and Allergy ,Medicine ,Single-Blind Method ,Vitamin B12 ,Letters to the Editor ,education ,Aged ,Pharmacology ,Plaque psoriasis ,education.field_of_study ,Emollients ,business.industry ,Pruritus ,Inflammatory skin disease ,psoriasis ,vitamin B12 ,Middle Aged ,medicine.disease ,Dermatology ,Vitamin B 12 ,Treatment Outcome ,hydration ,030220 oncology & carcinogenesis ,Quality of Life ,Female ,business - Abstract
Psoriasis is a chronic inflammatory skin disease affecting 2%–3% of the population. The wide range of drugs currently available for its treatment could be associated, in the long term, with organ toxicity and adverse events, thus, clinical monitoring throughout treatment is required. This investigator-initiated trial (IIT) evaluated the efficacy and the safety of a vitamin B12-containing ointment in comparison with glycerol-petrolatum-based emollient cream used twice a day to treat mild-to-moderate plaque psoriasis for a period over 12 weeks followed by a wash-out observation period of 4 weeks. This study was conducted as a randomized, controlled, single-blind, intra-patient left- to right-side trial comparing the efficacy and safety of vitamin B12-containing ointment (M-treatment) with a glycerol-petrolatum-based emollient cream (C-treatment). The Psoriasis Area Severity Index (PASI) was determined at baseline (T0), at time points T2 (14 days), T4 (4 weeks), T8 (8 weeks), T12 (12 weeks) and 4 weeks after the end of the wash-out period (F1). In total, 24 patients with plaque psoriasis were randomized to receive left- or right-side treatment with B12ointment. From time point T2 to time point F1, there was a statistically significant difference in PASI reduction between M-treatment side and C-treatment side. At time point T 12, the difference between the mean reductions from baseline PASI scores by 5.92 ± 2.49 (87, 6%) in the M-treatment side versus 1.08 ± 1.02 (23, 1%) C-treatment side was statistically highly significant ( PWex 12ointment will represent a new concrete therapy option and should be considered in the update of therapeutic algorithm for the treatment of psoriasis
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- 2017
16. Management of dermatologic toxicities associated with monoclonal antibody epidermal growth factor receptor inhibitors: A case review
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Laura Paletta, Gino Perri, Christian Leporini, Francesca Saullo, Antonio Sorrentino, Gianluca Dima, Gaetana La Gattuta, Virginia Olivito, Giovambattista De Sarro, Rosa Toscano, Stefania Infusino, Gianfranco Filippelli, Maria Lucia, and Ugo Bottoni
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safety ,Oncology ,medicine.medical_specialty ,Colorectal cancer ,Cetuximab ,rash ,Pharmacology ,Growth factor receptor ,Papulopustular ,Internal medicine ,medicine ,Panitumumab ,dermatologic toxicity ,Pharmacology (medical) ,integumentary system ,business.industry ,Cancer ,Minocycline ,Case Review ,medicine.disease ,Rash ,medicine.symptom ,panitumumab ,business ,medicine.drug - Abstract
Introduction: The epidermal growth factor receptor inhibitors (EGFRIs), cetuximab and panitumumab, represent an effective treatment option for patients affected by metastatic colorectal cancer (mCRC); furthermore, they are relatively devoid of systemic toxicities, which are commonly observed with standard cytotoxic chemotherapy. However, the majority of patients treated with these monoclonal antibodies (mAbs), will experience dermatologic toxicities, most notably the papulopustular skin rash, which can impact quality-of-life and affect adherence to therapy. This paper reviews the most recent practices in the management of skin rash related to anti-epidermal growth factor receptor (EGFR) mAbs, cetuximab and panitumumab, in the treatment of mCRC. Materials and Methods: We reviewed relevant literature regarding dermatologic toxicities associated with anti-EGFR mAbs in order to give important indications about prevention and reactive treatment of skin rash. Results: Two case reports were presented to show how skin rash could hamper mAb EGFRIs use in clinical practice, underscoring the need of implementing a comprehensive management strategy of skin toxicity in order to promote patients' compliance with anti-EGFR therapy and maintain quality-of-life. Based on randomized data, recent guidelines established by the Multinational Association for Supportive Care in Cancer Skin Toxicity Study Group suggest that prophylactic use of oral doxycycline or minocycline reduces the risk and severity of skin rash, improving clinical outcomes. Conclusions: At the start of treatment with cetuximab and panitumumab, the proper patient education about the skin rash associated with these mAbs and the implementation of a pre-emptive, comprehensive skin toxicity program significantly contribute to improve adherence to therapy, optimize anti-EGFR therapy and maintain quality-of-life.
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- 2013
17. Sequential treatment of daylight photodynamic therapy and imiquimod 5% cream for the treatment of superficial basal cell carcinoma on sun exposed areas
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Franca Cantoresi, Dario Didona, Domenico Piccolo, Santo Raffaele Mercuri, Mariagrazia Tallarico, Aikaterini Kyriakou, Marco Scarnò, Carmen Cantisani, Giovanni Paolino, Stefano Calvieri, and Ugo Bottoni
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Male ,Imiquimod 5% cream ,medicine.medical_specialty ,Skin Neoplasms ,medicine.medical_treatment ,Treatment outcome ,Antineoplastic Agents ,Photodynamic therapy ,Dermatology ,carcinoma ,basal cell ,Superficial basal cell carcinoma ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Carcinoma ,Humans ,Medicine ,Daylight ,aged ,antineoplastic agents ,carcinoma, basal cell ,female ,humans ,imiquimod ,male ,photochemotherapy ,skin neoplasms ,sunlight ,treatment outcome ,Aged ,Imiquimod ,business.industry ,General Medicine ,medicine.disease ,Sequential treatment ,Treatment Outcome ,Photochemotherapy ,Carcinoma, Basal Cell ,030220 oncology & carcinogenesis ,Sunlight ,Female ,business - Published
- 2018
18. Pitted keratolysis, erythromycin, and hyperhidrosis
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Marta Carlesimo, Guglielmo Pranteda, Miriam Grimaldi, Giulia Pranteda, Sabrina De Micco, Marta Muscianese, Ugo Bottoni, and C. Abruzzese
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medicine.medical_specialty ,business.industry ,Hyperhidrosis ,Erythromycin ,Topical treatment ,Dermatology ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Antibiotic therapy ,medicine ,Eccrine sweat gland ,medicine.symptom ,business ,Clinical evaluation ,medicine.drug ,Pitted keratolysis - Abstract
Pitted keratolysis (PK) is a plantar skin disorder mainly caused by coryneform bacteria. A common treatment consists of the topical use of erythromycin. Hyperhidrosis is considered a predisposing factor for bacterial proliferation and, consequently, for the onset of PK. The aim of this study was to evaluate the relationship between PK erythromycin and hyperhidrosis. All patients with PK seen in Sant'Andrea Hospital, between January 2009 and December 2011, were collected. PK was clinically and microscopically diagnosed. All patients underwent only topical treatment with erythromycin 3% gel twice daily. At the beginning of the study and after 5 and 10 days of treatment, a clinical evaluation and a gravimetric measurement of plantar sweating were assessed. A total of 97 patients were diagnosed as PK and were included in the study. Gravimetric measurements showed that in 94 of 97 examined patients (96.90%) at the time of the diagnosis, there was a bilateral excessive sweating occurring specifically in the areas affected by PK. After 10 days of antibiotic therapy, hyperhidrosis regressed together with the clinical manifestations. According to these data, we hypothesize that hyperhidrosis is due to an eccrine sweat gland hyperfunction, probably secondary to bacterial infection.
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- 2013
19. Time course, clinical pathways, and long-term hazards risk trends of disease progression in patients with classic mycosis fungoides
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Piergiacomo Calzavara-Pinton, Serena Rupoli, Angelo Carbone, Angela Maria Mamusa, Ugo Bottoni, Nicola Pimpinelli, Paolo Fava, Pietro Quaglino, Mauro Alaibac, Emilio Berti, Stefano Titli, Maria Grazia Bernengo, Michele Fimiani, Pier Luigi Zinzani, Giuseppe Alfonso Lombardo, Quaglino, P, Pimpinelli, N, Berti, E, Calzavara Pinton, P, Alfonso Lombardo, G, Rupoli, S, Alaibac, M, Bottoni, U, Carbone, A, Fava, P, Fimiani, M, Mamusa, A, Titli, S, Zinzani, P, Bernengo, M, Quaglino P, Pimpinelli N, Berti E, Calzavara-Pinton P, Alfonso Lombardo G, Rupoli S, Alaibac M, Bottoni U, Carbone A, Fava P, Fimiani M, Mamusa AM, Titli S, Zinzani, P L, Bernengo MG, and On behalf of the Gruppo Italiano Linfomi Cutanei (GILC).
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Adult ,Male ,Oncology ,Cancer Research ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,Erythroderma ,Disease ,Cutaneous lymphoma ,Follow-Up Studie ,Retrospective Studie ,Internal medicine ,classification, cutaneous T-cell lymphoma, erythroderma, multivariate analysis, mycosis fungoides, prognosis, tumor-lymph node-metastasis-blood (TNMB), tumor-stage ,Humans ,Medicine ,Skin Neoplasm ,cutaneous T-cell lymphoma ,Child ,tumor-lymph node-metastasis-blood (TNMB) ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,Mycosis Fungoide ,Mycosis fungoides ,mycosis fungoides ,business.industry ,erythroderma ,Cutaneous T-cell lymphoma ,Cancer ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Lymphoma ,multivariate analysis ,classification ,Disease Progression ,Female ,prognosis ,business ,prognosi ,Human ,Follow-Up Studies ,tumor-stage - Abstract
BACKGROUND: Mycosis fungoides (MF) is an indolent primary cutaneous T-cell lymphoma. To the authors' knowledge, no data currently are available regarding the evolution over time of the risk of developing specific pathways of disease progression. METHODS: This retrospective study analyzed 1422 patients with MF who were diagnosed and followed from 1975 through 2010 in 27 Italian Study Group for Cutaneous Lymphoma centers. The primary objectives were to ascertain the time course, pathways, and hazards risk trends of cutaneous/extracutaneous disease progression; to evaluate whether different tumor-lymph node-metastasis-blood (TNMB) stages have different pathways of disease progression; and to analyze differences between tumor-stage and erythrodermic MF with regard to clinical onset, disease evolution, and prognosis. The secondary objective was to provide a further validation for the revised International Society for Cutaneous Lymphomas and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (ISCL/EORTC) classification. RESULTS: The median follow-up was 14.5 years; stage progression occurred in 29.7% of patients and blood involvement was the most frequent extracutaneous site of disease progression. Patients with stage IA to stage IB disease demonstrated a steady low annual incidence of disease progression to tumor-stage (1%-2%); patients with stage IIA disease had a higher risk within the first years (up to 9.4%). Erythroderma evolved with a significantly higher frequency from patches/plaques (13.9%/28.2%) than tumors (P = .028 and P = .013, respectively). Hazards rates of extracutaneous involvement were low (< 1%). The T-score was found to be associated with extracutaneous involvement site, tumor-stage disease with lymph node/visceral lesions, and erythroderma with blood involvement. TNMB classification and stage progression resulted as independent prognostic variables being detected on multivariate analysis; the type of extracutaneous involvement was found to affect survival . CONCLUSIONS: The data from the current study support the need for a stage-tailored follow-up, suggest that the classification of tumor-stage disease at a stage below erythroderma could be modified, and offer a further validation for the revised TNMB classification. Cancer 2012. © 2012 American Cancer Society.
- Published
- 2012
20. Melanoma with unknown primary: report and analysis of 24 patients
- Author
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Giovanni Paolino, Paola Corsetti, Rita Clerico, Marina Ambrifi, Stefano Calvieri, Ugo Bottoni, and Valeria Devirgiliis
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Adult ,Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,Adolescent ,Vitiligo ,survival ,Lesion ,immune system ,melanocytes ,melanoma ,occult primary ,Internal medicine ,medicine ,Humans ,Stage (cooking) ,Survival rate ,Aged ,Retrospective Studies ,Aged, 80 and over ,Hematology ,business.industry ,Incidence (epidemiology) ,Melanoma ,Retrospective cohort study ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Neoplasms, Unknown Primary ,Female ,medicine.symptom ,business - Abstract
In the literature, there are some papers report- ing on patients with metastatic melanoma from an unknown primary lesion (MUP). The pathogenesis of this phenomenon and the prognosis of these patients are still debatable. Therefore, we reviewed our casistics on MUP patients. We identified 24 MUP patients out of all patients registered into a melanoma database from June 1996 to June 2011. The incidence was 1.4 %. We compared the survival rate of all patients with MUP stage III-IV with all patients with metastatic melanoma known primary (MMKP) stage III-IV observing a clear survival improvement for MUP patients in front of MMKP patients (p \ 0.01). In a second instance, we compared stage III MUP patients with only lymph nodal involvement with stage III MMKP patients with only lymph nodal involve- ment, and again we found statistically significant better survival for MUP patients (p \ 0.05). In this retrospective study, the number of lymph nodes involved (p = 0.8), the sex (p = 0.9), and S100 value (p = 0.2) were not statisti- cally relevant for prognosis. The better prognosis for these patients is very similar to better survival rate for metastatic melanoma patients and vitiligo. This correlation may be in accord with the hypothesis of a regression of primary lesion by immunological system of the host and also the median age of patients at the time of diagnosis, commonly older than melanoma patients, may correspond to a long period of immunological interferences between the host and the melanoma disease.
- Published
- 2012
21. Infrared Saliva Analysis of Psoriatic and Diabetic Patients: Similarities in Protein Components
- Author
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Steven Paul Nisticò, Salvatore A. Pullano, Stefano Dastoli, Raffaele Tiriolo, Ugo Bottoni, Antonino S. Fiorillo, and Giuseppe Fabrizio Amoruso
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Adult ,Male ,medicine.medical_specialty ,Pathology ,Saliva ,Spectrophotometry, Infrared ,Population ,Biomedical Engineering ,02 engineering and technology ,01 natural sciences ,Gastroenterology ,Saliva analysis ,Internal medicine ,Diabetes mellitus ,Psoriasis ,medicine ,Diabetes Mellitus ,Chronic skin disease ,Humans ,Salivary Proteins and Peptides ,education ,Aged ,education.field_of_study ,Principal Component Analysis ,Clinical pathology ,business.industry ,010401 analytical chemistry ,Case-control study ,Middle Aged ,021001 nanoscience & nanotechnology ,medicine.disease ,0104 chemical sciences ,Case-Control Studies ,Female ,0210 nano-technology ,business - Abstract
Goal: Psoriasis is a chronic skin disease which is very common in the population and requires frequent clinical and pharmacological treatment. In the following, a study based on Fourier transform infrared spectroscopy analyzing saliva proteomic components in psoriatic patients against diabetic patients and a control group is presented. Clinical analysis showed a prominent amide II band, at around 1545 cm−1, and the composition of the amide I band, at around 1647 cm−1, allowing us to distinguish the infrared salivary signature of psoriatic and diabetic patients from the control group and even from patients with different kinds of psoriasis. Moreover, results highlighted existing differences in the secondary structure composition of proteins between psoriatic and diabetic patients as compared to the control group. In fact, the saliva spectra of the control group and that of the palmoplantar psoriatic patients differ from plaque psoriasis and diabetic patient spectra because of the absence of the amide II band and the presence of different secondary protein-structure conformations.
- Published
- 2015
22. Differences in clinicopathological features and distribution of risk factors in Italian melanoma patients
- Author
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Stefano Cavicchini, Fabrizio Fantini, M. A. Tomassini, Andrea Maurichi, Ga Vena, Rodolfo Capizzi, V. Girgenti, Camilla Salvini, Paolo Fava, Chiara Astrua, Paola Savoia, Ugo Bottoni, Caterina Catricalà, Giorgio Filosa, Alessandra Chiarugi, D. Strippoli, R. Clerico, Marco Simonacci, Maria Antonietta Pizzichetta, Paolo Nardini, Elena Tolomio, Claudio Guarneri, P. Calzavara Pinton, Alessandro Borghi, Emanuele Crocetti, Enrico Colombo, Annalisa Patrizi, Mario Santinami, Pietro Rubegni, Erika Giulioni, Maria Concetta Fargnoli, L. Zichichi, Manuela Papini, Paolo Lisi, Mauro Alaibac, Giuseppe Argenziano, P. De Simone, Maria Teresa Corradin, Arianna Lamberti, Ketty Peris, A. Annetta, Caterina Ferreli, Pietro Quaglino, Nicola Pimpinelli, A. M. Manganoni, Fava, P, Astrua, C, Chiarugi, A, Crocetti, E, Pimpinelli, N, Fargnoli, Mc, Maurichi, A, Rubegni, P, Manganoni, Am, Bottoni, U, Catricala, C, Cavicchini, S, Santinami, M, Alaibac, M, Annetta, A, Borghi, A, Pinton, Pc, Capizzi, R, Clerico, R, Colombo, E, Corradin, Mt, De Simone, P, Fantini, F, Ferreli, C, Filosa, G, Girgenti, V, Giulioni, E, Guarneri, C, Lamberti, A, Lisi, P, Nardini, P, Papini, M, Peris, K, Pizzichetta, Ma, Salvini, C, Savoia, P, Strippoli, D, Tolomio, E, Tomassini, Ma, Vena, Ga, Zichichi, L, Patrizi, A, Argenziano, G, Simonacci, M, Quaglino, P, Fava P, Astrua C, Chiarugi A, Crocetti E, Pimpinelli N, Fargnoli MC, Maurichi A, Rubegni P, Manganoni AM, Bottoni U, Catricalà C, Cavicchini S, Santinami M, Alaibac M, Annetta A, Borghi A, Calzavara Pinton P, Capizzi R, Clerico R, Colombo E, Corradin MT, De Simone P, Fantini F, Ferreli C, Filosa G, Girgenti V, Giulioni E, Guarneri C, Lamberti A, Lisi P, Nardini P, Papini M, Peris K, Pizzichetta MA, Salvini C, Savoia P, Strippoli D, Tolomio E, Tomassini MA, Vena GA, Zichichi L, Patrizi A, Argenziano G, Simonacci M, Quaglino P., Catricalà, C, Calzavara Pinton, P, Argenziano, Giuseppe, and Quaglino, P.
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medicine.medical_specialty ,Skin Neoplasms ,Referral ,Epidemiology ,Dermato-oncology, Epidemiology, Melanoma, Risk factors ,Distribution (economics) ,Dermatology ,NO ,Dermato-oncology ,Melanoma ,Risk factors ,Humans ,Italy ,Middle Aged ,Risk Factors ,2708 ,Medicine (all) ,melanoma ,Medicine ,risk factors ,business.industry ,medicine.disease ,Phototype ,Frequent use ,Immunology ,Clinicopathological features ,Observational study ,business ,Settore MED/35 - MALATTIE CUTANEE E VENEREE - Abstract
Background: No studies are available in the literature on the distribution of different melanoma features and risk factors in the Italian geographical areas. Objective: To identify the differences in clinical-pathological features of melanoma, the distribution of risk factors and sun exposure in various Italian macro-areas. Methods: Multicentric-observational study involving 1,472 melanoma cases (713 north, 345 centre, 414 south) from 26 referral centres belonging to the Italian Multidisciplinary Group for Melanoma. Results: Melanoma patients in northern regions are younger, with thinner melanoma, multiple primaries, lower-intermediate phototype and higher counts of naevi with respect to southern patients; detection of a primary was mostly connected with a physician examination, while relatives were more involved in the south. Northern patients reported a more frequent use of sunbeds and occurrence of sunburns before melanoma despite sunscreen use and a lower sun exposure during the central hours of the day. Conclusions: The understanding of differences in risk factors distribution could represent the basis for tailored prevention programmes.
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- 2015
23. Transitory Acquired Flagellate Ictyosis, an Easy Treatment
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Ugo Bottoni, Giulia Pranteda, Claudia Abruzzese¸ Manuel Tuzi, Enrica Sper, Isabella Carboni, Marta Muscianese, and Guglielmo Pranteda
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Pathology ,medicine.medical_specialty ,Cell layer ,biology ,Flagellate dermatitis ,business.industry ,medicine ,Thermal water ,Flagellate ,biology.organism_classification ,business - Abstract
We described the case of 45 years-old woman affected by a flagellate dermatitis arisen immediately after having a bath in sulfurous thermal water. Such dermopathy resolved after a common scratching of the lesions by the patient, so that the possible pathogenetic mechanism to explain the resolution of the lesions is the mechanical removal of cornified cell layer. After six months follow-up, the patient is in good conditions, without relapses of the flagellate dermatitis.
- Published
- 2015
24. Association between autoimmune disease and cutaneous melanoma with regard to melanoma prognosis
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Giovanni Paolino, Carmen Cantisani, Marina Ambrifi, Rita Clerico, Dario Didona, Paola Corsetti, Marcello Albanesi, Paolo Lido, A. Brachini, Antonio Giovanni Richetta, Stefano Calvieri, and Ugo Bottoni
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Oncology ,Adult ,Male ,Prognostic factor ,medicine.medical_specialty ,Skin Neoplasms ,Paraneoplastic Syndromes ,Antineoplastic Agents ,Autoimmunity ,Dermatology ,Kaplan-Meier Estimate ,medicine.disease_cause ,Disease-Free Survival ,Autoimmune Diseases ,Young Adult ,Internal medicine ,medicine ,Adjuvant therapy ,Humans ,In patient ,Melanoma ,Survival analysis ,Aged ,Autoimmune disease ,Aged, 80 and over ,business.industry ,Middle Aged ,medicine.disease ,Prognosis ,Cutaneous melanoma ,Immunology ,Female ,business - Abstract
Summary Background An association between autoimmune disease and malignant melanoma (MM) has often been reported in the literature as a positive prognostic factor for MM. Consequently, we evaluated the influence of different autoimmune diseases on the prognosis of MM. Aim To evaluate the prognosis of patients with MM who also had an autoimmune disorder, whether tumour-associated, paraneoplastic or drug-induced. Methods Autoimmune diseases were classified and analysed as tumour-associated, paraneoplastic or drug-induced. Patients were enrolled according to their clinicopathological features and matched with control groups. Kaplan–Meier analysis was used to estimate disease-free survival (DFS) and overall survival (OS), and log-rank test was used to evaluate differences between the survival curves. Results In total, 49 patients with MM and tumour-associated autoimmune disease were included in our analysis. No case of paraneoplastic autoimmune disease was detected. The survival analyses showed a range of results, from a worsening of DFS and OS to a lack of any difference. In a second analysis, we separately analysed patients who developed autoimmune disorders after starting adjuvant therapy with interferon-α; we did not find significant differences between these patients and the untreated patients. Conclusions Autoimmune disease, whether tumour-associated or drug-induced, was not associated with better prognosis in patients with MM. The results suggest that the reported relationship between autoimmunity and MM may be a result of individual variation in sensitivity to the autoimmune disease, the tumour or the treatments.
- Published
- 2015
25. Clinicopathological features, vitamin D serological levels and prognosis in cutaneous melanoma of shield-sites. An update
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Carmen Cantisani, Giovanni Paolino, Valentina Garelli, Antonio Giovanni Richetta, Dario Didona, Stefano Calvieri, Ugo Bottoni, Teresa Lopez, Elisa Moliterni, and Paola Corsetti
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Adult ,Male ,Proto-Oncogene Proteins B-raf ,Cancer Research ,medicine.medical_specialty ,Pathology ,Skin Neoplasms ,Kaplan-Meier Estimate ,Disease ,Gastroenterology ,BRAF ,melanoma ,predictors ,prognosis ,shield-sites ,vitamin D ,oncology ,cancer research ,ematology ,Disease-Free Survival ,Serology ,Internal medicine ,Vitamin D and neurology ,Humans ,Medicine ,Vitamin D ,Melanoma ,Aged ,Retrospective Studies ,Hematology ,business.industry ,Retrospective cohort study ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Oncology ,Mutation ,Cutaneous melanoma ,Sunlight ,Clinicopathological features ,Female ,business - Abstract
Intermittent sun exposure and sunburns are strongly related to the development of melanoma (MM); however, MM can also arise in non-sun exposed areas, where other biological pathways may cause the disease, with different outcomes. At the same time, evidences of serum levels of vitamin D in melanoma patients according to sun-exposed or not-sun-exposed areas are still lacking, especially if compared with the percentage of BRAF mutation. We performed a retrospective analysis with patients registered in our electronic database and an observational study in patients with a recent diagnosis of MM. Performing Kaplan–Meier product and log-rank test, median disease-free survival was 78 months in non-shield-sites (NST-MM) patients and 20.5 months in shield-sites (ST-MM) patients (p
- Published
- 2015
26. Patterns of Detection of Superficial Spreading and Nodular-Type Melanoma: A Multicenter Italian Study
- Author
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Paolo Carli, Domenico Dioguardi, Vincenzo De Giorgi, G. Imberti, Giovanni Lo Scocco, Massimiliano Scalvenzi, Domenico Palli, Catiuscia Orlandi, Ugo Bottoni, Patrizio Mulas, Roberto Betti, Benvenuto Giannotti, Caterina Catricala, Ignazio Stanganelli, Andrea Maurichi, Pierfranco Soma, and Simone Paoli
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Adult ,Male ,medicine.medical_specialty ,Pathology ,Skin Neoplasms ,Dermatology ,Thick melanoma ,Surveys and Questionnaires ,medicine ,Humans ,Registries ,Melanoma ,neoplasms ,Melanoma diagnosis ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Atypical nevus ,Original data ,Logistic Models ,Italy ,Late diagnosis ,Multicenter study ,Logistic analysis ,Female ,Surgery ,business - Abstract
Nodular histotype represents the condition that is mostly associated with diagnosis of thick melanoma.The objectives were to evaluate variables associated with and pattern of detection of nodular melanomas and to investigate variables associated with early diagnosis in accordance with histotype (nodular vs. superficial spreading melanomas).From the original data set of 816 melanomas, all the invasive lesions classified as superficial spreading (n=500) and nodular (n=93) melanomas were considered for the study. A multivariate logistic analysis was performed. Results. Nodular melanomas did not significantly differ from superficial spreading melanomas regarding sex, anatomic site, number of whole-body nevi, and the presence of atypical nevi. As expected, nodular melanomas were represented by a higher percentage of thick (2 mm) lesions compared to superficial spreading melanomas (64.5% vs. 9.6%, p0.001). The pattern of detection significantly differed between nodular and superficial spreading melanomas, the former being more frequently self-detected (44.1% vs. 38.0%) or detected by the family doctor (34.4% vs. 11.4%). Female sex, high level of education, and detection made by a dermatologist had an independent, protective effect against late (1 mm in thickness) diagnosis in superficial spreading melanomas. No protective variable associated with nodular melanomas was found.Patterns of detection for nodular melanomas significantly differ from those for superficial spreading melanomas. For superficial spreading, but not for nodular, melanomas, variables associated with protective effect against late diagnosis can be identified.
- Published
- 2004
27. Serum tryptase levels in melanoma patients
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Valentina Garelli, Antonio Giovanni Richetta, Teresa Lopez, Giulia Macrì, Giovanni Paolino, Stefano Calvieri, Ugo Bottoni, Dario Didona, Michele Cardone, and Elisa Moliterni
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Cancer Research ,medicine.medical_specialty ,Pathology ,business.industry ,Melanoma ,Dermatology ,medicine.disease ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,Humans ,Medicine ,Clinicopathological features ,Tryptases ,business ,Serum tryptase - Published
- 2016
28. GRANULOMA ANNULARIS REVEALING WEGENER'S GRANULOMATOSIS
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Livia Ferri, Marta Muscianese, Maria Proietta, N. Cifani, Guglielmo Pranteda, Federica Tamburi, F. Del Porto, Ugo Bottoni, Guglielmo Bruno, and Steven Paul Nisticò
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Pharmacology ,Erythema nodosum ,medicine.medical_specialty ,integumentary system ,business.industry ,Immunology ,Arthritis ,wegener's granulomatosis ,granuloma annularis ,systemic autoimmune disease ,medicine.disease ,Dermatology ,Scleroderma ,Granuloma ,Rheumatoid arthritis ,medicine ,Immunology and Allergy ,Sarcoidosis ,skin and connective tissue diseases ,Granulomatosis with polyangiitis ,business ,Granuloma annulare - Abstract
Skin manifestations are often associated with systemic autoimmune diseases (SAD). Some SAD, such as systemic lupus erythematosus, psoriatic arthritis and scleroderma display pathognomonic dermatological features, whereas other systemic diseases such as sarcoidosis, vasculitis and rheumatoid arthritis can present with non-specific skin manifestations that range from erythema nodosum to necrotic lesions. Here we report the case of a 25-year-old man with uveitis, polyarthrirtis, pulmonary involvement, nephrotic syndrome, cutaneous granuloma and pneumonia by E. coli.
- Published
- 2014
29. Clinicopathological predictive factors of melanoma lung metastases
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Carmen Cantisani, Dario Didona, Federico Venuta, Giovanni Paolino, Paola Corsetti, Antonio Giovanni Richetta, Teresa Lopez, Rita Clerico, Marina Ambrifi, Stefano Calvieri, and Ugo Bottoni
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Oncology ,medicine.medical_specialty ,Poor prognosis ,Pathology ,Multivariate analysis ,Lung ,business.industry ,Melanoma ,melanoma ,lung ,metastases ,survival ,medicine.disease ,Omics ,Primary tumor ,medicine.anatomical_structure ,Internal medicine ,Cox proportional hazards regression ,medicine ,business ,Survival analysis - Abstract
Background: The lung is the second most common site for metastatic malignant melanoma, with a poor prognosis. In this regard, identify clinicopathological predictors for Melanoma Lung Metastases (MLM) plays a pivotal role in clinical practice. Methods: We computer-searched the clinical records of all our patients registered in our melanoma database to identify patients that presented MLM. Kaplan-Meier product was used to estimate time to MELANOMA LUNG METASTASES (TMLM) and Overall Survival (OS); while the log-rank test was used to evaluate differences between the survival curves. Cox proportional hazards regression was performed in the analysis between clinicopathological features of the primary tumor and MLM. Results: A total of 63 patients with MLM were included in our analysis. Median TMLM was 27.4 months, while median OS was 55.5 months, with a Median Lung Metastases Survival (MLMS) of 10 months. Melanoma patients with a primary axial tumor (p
- Published
- 2014
30. Thin melanoma and late recurrences: it is never too thin and never too late
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Antonio Giovanni Richetta, Giovanni Paolino, Carmen Cantisani, Paola Corsetti, Marina Ambrifi, Rita Clerico, Stefano Calvieri, and Ugo Bottoni
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Male ,Cancer Research ,medicine.medical_specialty ,Sentinel lymph node ,Kaplan-Meier Estimate ,Disease-Free Survival ,Cohort Studies ,Recurrence ,Risk Factors ,Statistical significance ,Biopsy ,medicine ,Humans ,Neoplasm Metastasis ,Melanoma ,Survival analysis ,Proportional Hazards Models ,medicine.diagnostic_test ,Female ,Middle Aged ,Sentinel Lymph Node Biopsy ,Treatment Outcome ,business.industry ,Proportional hazards model ,Hematology ,General Medicine ,medicine.disease ,Surgery ,Oncology ,Cohort ,Radiology ,business ,Cohort study - Abstract
In the absence of risk factors, thin melanomas (TM) present a long-term survival; however, recurrences may occur. We describe the predictive clinicopathological features of patients with metastatic TM. Kaplan-Meier product was performed for the survival analysis, while Cox proportional hazards regression was used to evaluate the effect of the clinicopathological features on disease-free survival (DFS) and overall survival (OS). Median DFS of the entire cohort was 26 months and three patients developed late metastases. Nine patients developed extra-nodal metastases as first recurrence, while cases of positive sentinel lymph node biopsy (SLNB) were not found. DFS and OS varied according to the clinicopathological features, but only ulceration remained the main statistical significance value. According to our results, a hypothetical use of SLNB in TM without other risk factors is not currently feasible. No consensus exists as to which patients with TM are at risk for metastases or late recurrences.
- Published
- 2014
31. Dermoscopy of a Plantar Combined Blue Nevus: A Simulator of Melanoma
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Monica Mancini, Daniele Innocenzi, Michela Curzio, M. Rossi, B. Mastrecchia, Stefano Calvieri, Ugo Bottoni, Valeria Devirgiliis, R.G. Borroni, and Vincenzo Panasiti
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medicine.medical_specialty ,Pathology ,Skin Neoplasms ,parallel ridge pattern ,Early detection ,Dermatology ,Histopathological examination ,acral volar skin ,blue nevus ,Diagnosis, Differential ,Foot Diseases ,combined ,dermoscopy ,Nevus, Blue ,medicine ,Humans ,Nevus ,skin and connective tissue diseases ,Melanoma ,neoplasms ,Melanoma diagnosis ,Blue nevus ,Skin ,Dermatoscopy ,integumentary system ,medicine.diagnostic_test ,business.industry ,Papule ,Middle Aged ,medicine.disease ,Female ,medicine.symptom ,business - Abstract
Dermoscopy allows early detection of melanoma also on acral volar skin. The majority of melanocytic nevi on palms and soles may show three major dermoscopic patterns: the parallel-furrow pattern, the lattice-like pattern, and the fibrillar pattern. Melanomas at these sites are characterized by the parallel ridge pattern. We present the case of a 59-year-old woman who had an oval papule of bluish color, measuring 0.6 x 0.9 cm, localized on her left sole, that had been present, unchanged, for more than 10 years. Dermoscopy showed a parallel ridge pattern. The histopathological examination revealed a combined blue nevus. We present this case to underline that on acral volar skin also intradermal nevi, such as combined blue nevi, may dermoscopically exhibit a parallel ridge pattern, simulating melanoma.
- Published
- 2007
32. Pulmonary mycobacteriosis in a patient affected by mycosis fungoides: A diagnostic and therapeutic challenge
- Author
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Valeria Devirgiliis, R.G. Borroni, Monica Mancini, Vincenzo Panasiti, M. Rossi, Maurizio Martelli, Mario Venditti, Michela Curzio, Stefano Calvieri, Ugo Bottoni, Salvatore Delia, and Rita Clerico
- Subjects
Adult ,Lung Diseases ,Male ,Microbiology (medical) ,medicine.medical_specialty ,Skin Neoplasms ,medicine.medical_treatment ,Antitubercular Agents ,Asymptomatic ,Mycobacterium ,Sepsis ,Mycosis Fungoides ,hemic and lymphatic diseases ,medicine ,Humans ,Cause of death ,Mycobacterium Infections ,Mycosis fungoides ,Chemotherapy ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Dermatology ,Surgery ,Regimen ,Treatment Outcome ,Infectious Diseases ,Bronchoalveolar lavage ,complication ,ctcl ,infection ,mycobacteriosis ,mycosis fungoides ,Drug Therapy, Combination ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Complication - Abstract
Among patients with cutaneous T-cell lymphoma (CTCL), sepsis and pulmonary infections are the first cause of death. We report on a patient with CTCL who, after more than 10 years of aggressive antineoplastic treatments, showed extensive pulmonary infiltrations on staging CT scan. Repeated CT scans were inconclusive for an infectious process, and the patient was still asymptomatic. The diagnosis of mycobacteriosis was made on the microbiologic exam of bronchoalveolar lavage. Specific treatment was started with contemporary dosage reduction of chemotherapy. After six months of antibiotic treatment the pulmonary lesions improved, whereas CTCL progressed. Therefore, a new antineoplastic regimen was started obtaining control of CTCL, without aggravation of the pulmonary lesions. We highlight the diagnostic and therapeutic pitfalls encountered when pulmonary mycobacteriosis complicates the course and treatment of CTCL.
- Published
- 2006
33. Bullous lesions in chronic lymphocytic leukaemia: pemphigoid or insect bites?
- Author
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Maura Del Giudice, Franco Mandelli, Stefano Calvieri, Ugo Bottoni, Aurora Parodi, Emanuele Cozzani, Francesca Romana Mauro, Alfredo Rebora, and Daniele Innocenzi
- Subjects
Male ,Pemphigoid ,INSECT BITES ,medicine.medical_specialty ,Dermatology ,Diagnosis, Differential ,Pemphigoid, Bullous ,medicine ,Humans ,Lymphocytes ,Fluorescent Antibody Technique, Indirect ,Aged ,Lymphocytic leukaemia ,business.industry ,Insect Bites and Stings ,General Medicine ,Middle Aged ,medicine.disease ,Leukemia, Lymphocytic, Chronic, B-Cell ,Eosinophils ,Bullous lesions ,Fluorescent Antibody Technique, Direct ,Case-Control Studies ,Female ,business - Abstract
This article does not have an abstract.
- Published
- 2006
34. Erythema Multiforme Major after Whole Brain Radiotherapy: A Case of Emar Syndrome?
- Author
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V. Arcidiacono, Steven Paul Nistico, Stefano Calvieri, Ugo Bottoni, A. Sacco, and G.F. Amoruso
- Subjects
medicine.medical_specialty ,business.industry ,Immunology ,Whole brain radiotherapy ,lcsh:R ,lcsh:Medicine ,Metastatic Breast Carcinoma ,medicine.disease ,Dermatology ,Erythema multiforme major ,chemistry.chemical_compound ,medicine.anatomical_structure ,stomatognathic system ,Methylprednisolone ,Exemestane ,chemistry ,Scalp ,medicine ,Immunology and Allergy ,Erythema multiforme ,business ,medicine.drug - Abstract
We report the case of a woman with a 4-year history of metastatic breast carcinoma presenting a large erosive area on her scalp plus erosive lesions on the lips and in the mouth and erythematous plaques with vesicles on the trunk and upper limbs. In this case, contrary to other reports, the most important trigger for this syndrome was radiotherapy rather than the systemic medications administered. Therefore we propose the term EMAR (erythema multiforme associated to radiotherapy) to describe this case.
- Published
- 2013
35. Predictors and survival in patients with melanoma brain metastases
- Author
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Marina Ambrifi, Rita Clerico, Giovanni Paolino, Paola Corsetti, Stefano Calvieri, and Ugo Bottoni
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Pathology ,Skin Neoplasms ,Sentinel lymph node ,Kaplan-Meier Estimate ,Gastroenterology ,brain metastases ,predictive factors ,melanoma ,survival ,Breslow Thickness ,Internal medicine ,medicine ,Humans ,Melanoma ,Subclinical infection ,Hematology ,Brain Neoplasms ,Sentinel Lymph Node Biopsy ,business.industry ,Incidence (epidemiology) ,General Medicine ,Middle Aged ,medicine.disease ,Primary tumor ,Oncology ,Female ,business ,Brain metastasis - Abstract
Brain metastases (BM) are one of the most frequent neurological complications of cancers. Melanoma is the third most common tumor to metastasize to the brain with a reported incidence of 10–40 %, and many patients have subclinical BM (>73 %). We computer-searched the clinical records of all our patients registered into a database to identify patients that presented or developed BM. A total of 49 patients with melanoma BM were included in our analysis. General time to brain metastases (TTBM) was 23 months. The nonparametric test between TTBM and the single variables showed an association between TTBM and Breslow thickness (p
- Published
- 2013
36. NEUROCUTANEOUS MELANOSIS IN A WOMAN WITH MULTIPLE BRAIN MELANOCYTOMAS, CUTANEOUS MELANOCYTOSIS AND ORAL INVOLVEMENT
- Author
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Steven Paul Nistico, Andrea Amorosi, Valeria Zuccalà, F. Tamburi, A. L. Gabriele, Francesco Conforti, Giuseppe Donato, Giuseppe Nicoletti, and Ugo Bottoni
- Subjects
Right shoulder ,medicine.medical_specialty ,business.industry ,lcsh:R ,Immunology ,lcsh:Medicine ,Oral cavity ,medicine.disease ,Dermatology ,Neurocutaneous melanosis ,brain melanocytoma ,Immunology and Allergy ,Medicine ,neurocutaneous melanosis ,benign dermal melanocytic infiltration ,business - Abstract
A 34-year-old female was referred to us for a consultation of her dermatological lesions (pigmented lesions present in her oral cavity and on her right shoulder) in May 2007. These lesions had been present since childhood. Recently, the patient had developed seizures and a headache. An MRI of the brain showed the presence of two intracranial masses. The intracranial tumours were surgically removed whereas skin and mucosal lesions were biopsied. Histological findings of brain tumours were consistent with a diagnosis of “melanocytoma” while cutaneous lesions presented “benign dermal melanocytic infiltrations”. Whole brain irradiation was performed. After 3 months a new melanocytic skin lesion appeared on the scalp with histological picture similar to the other cutaneous ones. At the 5-year follow-up examination no recurrence of intracranial tumour or other skin or mucosal lesions were registered. According to the clinical and histological findings, we classify our case as a form of neurocutaneous melanosis in a young adult patient and we present it for the rarity of this syndrome, for the difficulty of the diagnosis, for the potential aggressive behaviour of intracranial lesions that necessitates a constant attentive follow-up and for the unusual feature of new developing skin lesion during the course of the disease.
- Published
- 2013
37. Tufted hair folliculitis: complete enduring response after treatment with rifampicin
- Author
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A. Di Napoli, Guglielmo Pranteda, Ugo Bottoni, E. Palese, and Miriam Grimaldi
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staphylococcus aureus ,medicine.medical_specialty ,medicine.drug_class ,Antibiotics ,Erythromycin ,Folliculitis ,Dermatology ,rifampicin ,Humans ,Medicine ,Antibacterial agent ,tufted hair folliculitis ,biology ,medicine.diagnostic_test ,business.industry ,Middle Aged ,biology.organism_classification ,medicine.disease ,Anti-Bacterial Agents ,Surgery ,medicine.anatomical_structure ,Scalp Dermatoses ,Scalp ,Skin biopsy ,Female ,Staphylococcal Skin Infections ,Rifampin ,business ,Cabello ,Rifampicin ,medicine.drug - Abstract
A 47-year-old woman presented with erythematous lesions with papules and pustules on her parieto-occipital region that had been present for 8 months. Areas of sclero-atrophic alopecia were evident, whereas at different points tufted hair shafts were coming out from single dilatated follicular ostia. Before our observation, an antibiotic oral therapy with tetracyclines and local with erythromycin had been administered to the patient, with partial improvement and relapse on its suspension.Bacterial culture from pustules showed the development of Staphylococcus aureus. A skin biopsy was done. According to clinical and histopathological findings a diagnosis of tufted hair folliculitis was made and a treatment with oral rifampicin was started at the dosage of 450 mg twice per day.After 3 weeks of therapy, the pustular lesions regressed completely and after a follow-up of 1 year no relapse was observed.Rifampicin is one of the best active antibiotics against S. aureus, which seems to play a role in the pathogenesis of tufted hair folliculitis. Our results, if further confirmed, may suggest a role for rifampicin either for the control of the pustular phase of this rare disorder or to prevent its relapses for a long time.
- Published
- 2004
38. Reversible acute global left ventricular dysfunction in a patient with autosomal recessive dystrophic epidermolysis bullosa
- Author
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Stefano Calvieri, Ugo Bottoni, Roberto Porciello, Morelli S, Alessandro Sgreccia, and Caterina Dianzani
- Subjects
medicine.medical_specialty ,Myocarditis ,Viral Myocarditis ,business.industry ,Cardiomyopathy ,Epidermolysis bullosa dystrophica ,epidermolysis bullosa dystrophica ,Dilated cardiomyopathy ,medicine.disease ,Dermatology ,Virus ,dilated cardiomyopathy ,Dystrophic epidermolysis bullosa ,Immunity ,medicine ,myocarditis ,Cardiology and Cardiovascular Medicine ,business - Abstract
We report for the first time a patient with autosomal recessive dystrophic epidermolysis bullosa, who developed dilated cardiomyopathy and recovered completely within 2 months. The benign course, the previous influenza-like syndrome, the impairment of immunity, the presence of malignant cutaneous lesions which contained DNA of "low risk" virus suggest that cardiomyopathy might have been secondary to acute viral myocarditis.
- Published
- 2001
39. Predictive factors for false negative sentinel lymph node in melanoma patients
- Author
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Nicolò Scuderi, Michela Curzio, Vincenzo Roberti, M. Rossi, Valeria Devirgiliis, Silvia Gobbi, Stefano Calvieri, Ugo Bottoni, Vincenzo Panasiti, and Rita Clerico
- Subjects
Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,Sentinel lymph node ,Dermatology ,Disease-Free Survival ,Young Adult ,Predictive Value of Tests ,Medicine ,Humans ,Lymph node ,Survival rate ,False Negative Reactions ,Melanoma ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Sentinel Lymph Node Biopsy ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Survival Analysis ,Surgery ,Survival Rate ,Dissection ,medicine.anatomical_structure ,Logistic Models ,Predictive value of tests ,Lymphatic Metastasis ,Lymph Node Excision ,Female ,Radiology ,Lymph Nodes ,business ,Follow-Up Studies - Abstract
BACKGROUND Sentinel lymph node biopsy (SLNB) represents a useful tool for staging melanoma patients. However false-negative SLNB are reported in the literature. OBJECTIVE The aim of our study is to identify predictive factors for false-negative SLNB in melanoma patients. MATERIALS AND METHODS We conducted a retrospective analysis on 316 melanoma patients who underwent SLNB and were followed up at the Department of Dermatology and Plastic Surgery of University of Rome “Sapienza” from March 1994 to June 2008. RESULTS In our patients, SLNB was positive in 35 cases (11.07%) whereas it was negative in 281 cases (88.93%); 12/316 patients (3.8%) had positive SLNB and positive therapeutic lymph node dissection (TLND); 23/316 (7.28%) patients had positive SLNB and negative TLND; 266/316 (84.18%) patients had negative SLNB but without subsequent metastases in the SLN site; 15/316 (4.74%) patients had negative SLNB, but with subsequent metastases in the same SLN site (false-negative patients). Among the different prognostic factors, only ulceration was the main predictive factor for false-negative SLNB, according to statistical analysis (p=.0420). CONCLUSION Our data confirm that SLNB is a useful technique for staging melanoma patients. However, in patients with negative SLNB, a closer follow-up is recommended when ulceration is present. The authors have indicated no significant interest with commercial supporters.
- Published
- 2010
40. Amoxicillin-clavulanic acid-induced linear immunoglobulin A bullous dermatosis: case report and review of the literature
- Author
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Stefano Calvieri, Ugo Bottoni, Valeria Devirgiliis, Vincenzo Panasiti, M. Rossi, and Michela Curzio
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Immunoglobulin A ,Male ,medicine.medical_specialty ,Amoxicillin/clavulanic acid ,integumentary system ,biology ,Skin Diseases, Vesiculobullous ,business.industry ,Dermatology ,Amoxicillin ,Dapsone ,Middle Aged ,Amoxicillin-Potassium Clavulanate Combination ,Clavulanic acid ,medicine ,biology.protein ,Humans ,Antibody ,skin and connective tissue diseases ,business ,Direct fluorescent antibody ,medicine.drug ,Antibacterial agent - Abstract
Background Linear immunoglobulin A bullous dermatosis (LABD) is an autoimmune subepidermal blistering disease, rarely induced by drugs. Methods We describe a case of a 47-year-old man who developed a severe blistering eruption after therapy with amoxicillin–clavulanic acid. Results Histopathologic examination and direct immunofluorescence were consistent with a diagnosis of LABD. Therapy with dapsone controlled the disease but, after sun exposure, there was a worsening of the illness. Conclusion To our knowledge, this is the first case of amoxicillin–clavulanic acid-induced LABD in an adult.
- Published
- 2009
41. The role of G-CSF in the treatment of advanced tumors
- Author
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Francesco Trapasso and Ugo Bottoni
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,Fas Ligand Protein ,Mammary Neoplasms ,Blotting, Western ,Apoptosis ,Granulocyte ,Adenocarcinoma ,TNF-Related Apoptosis-Inducing Ligand ,Mice ,Cell Line, Tumor ,Granulocyte Colony-Stimulating Factor ,medicine ,Animals ,Humans ,bcl-2-Associated X Protein ,Pharmacology ,Mice, Inbred BALB C ,Interleukin-13 ,business.industry ,Caspase 3 ,Tumor Necrosis Factor-alpha ,Mammary Neoplasms, Experimental ,Interleukin-12 ,Recombinant Proteins ,Blot ,medicine.anatomical_structure ,Oncology ,Proto-Oncogene Proteins c-bcl-2 ,Cell culture ,Molecular Medicine ,Experimental pathology ,Female ,business - Abstract
Commentary to:Peritumoral administration of granulocyte colony-stimulating factor induces an apoptotic response on a murine mammary adenocarcinomaJulieta Marino, Veronica A. Furmento, Elsa Zotta, Leonor P. Roguin
- Published
- 2009
42. Tenascin C: A defensive role in sentinel lymph nodes of melanoma patients?
- Author
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Nicolò Scuderi, Bruno Vincenzi, Carmine Alfano, Fortunata Vasaturo, Stefano Calvieri, Ugo Bottoni, Angela Gradilone, Anna Maria Aglianò, Paola Gazzaniga, Luigi Frati, and Emanuele Cigna
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,adhesion molecules ,prognosis ,rt-pcr ,tenascin c ,Dermatology ,Biochemistry ,80 and over ,medicine ,Biomarkers, Tumor ,Humans ,Molecular Biology ,Melanoma ,Aged ,Retrospective Studies ,Aged, 80 and over ,Tumor ,biology ,Cell adhesion molecule ,business.industry ,Sentinel Lymph Node Biopsy ,Tenascin C ,Tenascin ,Middle Aged ,medicine.disease ,Adhesion molecules ,Prognosis ,RT-PCR ,Disease Progression ,Female ,Lymph Nodes ,Real-time polymerase chain reaction ,biology.protein ,Lymph ,business ,Biomarkers - Published
- 2009
43. Erythema annulare centrifugum as the presenting sign of breast carcinoma
- Author
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Stefano Calvieri, Ugo Bottoni, M. Rossi, Michela Curzio, Valeria Devirgiliis, Vincenzo Panasiti, and Vincenzo Roberti
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Erythema annulare centrifugum ,business.industry ,MEDLINE ,Dermatology ,medicine.disease ,Infectious Diseases ,Carcinoma ,medicine ,Mammography ,business ,Breast carcinoma ,Sign (mathematics) - Published
- 2009
44. The reticular point of view in dermatoscopy
- Author
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Vincenzo Roberti, Raffaele Masciangelo, Vincenzo Panasiti, Benedetto Mastrecchia, Stefano Calvieri, Michela Curzio, Ugo Bottoni, Valeria Devirgiliis, and Silvia Gobbi
- Subjects
medicine.medical_specialty ,Skin Neoplasms ,pigment network ,Dermoscopy ,Skin Pigmentation ,Dermatology ,dermatoscopy ,Malignancy ,Sensitivity and Specificity ,Severity of Illness Index ,Lesion ,Diagnosis, Differential ,medicine ,melanoma ,Humans ,Dermatoscopy ,Nevus, Pigmented ,algorithm ,medicine.diagnostic_test ,business.industry ,Melanoma ,Reproducibility of Results ,Melanocytic nevus ,medicine.disease ,ROC Curve ,Dysplasia ,Reticular connective tissue ,Dysplastic nevus ,medicine.symptom ,business ,Dysplastic Nevus Syndrome ,Algorithms - Abstract
Background Different dermatoscopic algorithms have been developed to evaluate pigmented lesions of the skin, with pattern analysis being the most commonly used. We sought to develop and evaluate a diagnostic scoring system, the reticular point of view, to distinguish common melanocytic nevus from dysplastic nevus and from melanoma. Methods We analyzed 1543 pigmented lesions, most of which contained a pigment network, and assessed the presence of linear extensions, thickened or hyperpigmented lines, areas of abrupt cut off, and areas with large "holes." We then conducted statistical analyses on these parameters to verify which of these exerted the most influence on the dermatologist's decision to surgically excise the lesion and to verify which feature was most linked to histopathologic signs of dysplasia or malignancy. Results Among the lesions excised, histopathologic examination revealed 33 (10.28%) melanomas. Among these, 25 (75.75%) showed an asymmetric distribution of the pigment network, whereas 20 (60.6%) showed a linear extension of it. The analysis of our data showed that all the evaluated criteria were statistically significant and played an important role in the dermatologist's decision to perform surgical excision of the lesion. Regarding the diagnosis of melanoma, only the presence of large holes, areas of abrupt cut off, and linear extensions revealed statistical significance. Limitations Reticular point of view may be useful only in lesions with a large pigment network. It is not applicable in nodular, thick, and amelanotic melanomas that are usually lacking in pigment network. Conclusion Although pattern analysis represents the most effective analytical method in dermatoscopy, our scoring system may be useful to distinguish between benign lesions, which need only clinical follow-up, and malignant lesions, which need surgical excision.
- Published
- 2009
45. Bullous keloid: a distinct entity?
- Author
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P. De Simone, Guglielmo Pranteda, Teresa Grieco, Stefano Calvieri, and Ugo Bottoni
- Subjects
medicine.medical_specialty ,Keloid ,business.industry ,medicine ,Dermatology ,medicine.disease ,business - Published
- 1999
46. Epidemiology of dermatophytic infections in Rome, Italy: a retrospective study from 2002 to 2004
- Author
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Vincenzo Panasiti, Valeria Devirgiliis, Michela Curzio, Stefano Calvieri, Ugo Bottoni, M. Rossi, R.G. Borroni, and Monica Mancini
- Subjects
Adult ,Male ,medicine.medical_specialty ,Veterinary medicine ,Adolescent ,dermatophytes ,Rome ,medicine.disease_cause ,tinea ,Trichophyton ,Epidemiology ,medicine ,Dermatomycoses ,Humans ,Microsporum ,Microsporum canis ,Child ,Aged ,Retrospective Studies ,Aged, 80 and over ,Geographic area ,biology ,business.industry ,Incidence (epidemiology) ,Incidence ,Infant ,Retrospective cohort study ,General Medicine ,epidemiology ,Middle Aged ,biology.organism_classification ,Dermatology ,Infectious Diseases ,Child, Preschool ,Dermatophyte ,Female ,business ,Arthrodermataceae - Abstract
In the present study, we determined the incidence of dermatophyte species causing superficial mycoses among outpatients referred to the Department of Dermatology of the “La Sapienza” University of Rome between 2002 and 2004. Of the 3160 subjects studied, 1275 (40.3%) were positive for fungal infection, but only 252 (19.7%) of these had infections caused by dermatophytes. The dermatophyte most frequently isolated was Microsporum canis. Our epidemiological data were compared with those obtained previously by other authors in the same geographic area. For the first time we described an inversion of the T. rubrum/T. mentagrophytes ratio, the latter being more frequently encountered. We also observed the emergence of M. audouinii.
- Published
- 2007
47. Management of skin ulcers in a patient with mycosis fungoides
- Author
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Vincenzo Panasiti, Stefano Calvieri, M. Rossi, Ugo Bottoni, R.G. Borroni, Michela Curzio, Valeria Devirgiliis, and Monica Mancini
- Subjects
Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,Lymphoma ,Dermatology ,Skin infection ,Sepsis ,Mycosis Fungoides ,hemic and lymphatic diseases ,Antineoplastic Combined Chemotherapy Protocols ,Skin Ulcer ,medicine ,Humans ,cancer ,Stage (cooking) ,mycosis ,Cause of death ,Mycosis fungoides ,business.industry ,Hydrogels ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Abdomen ,Wound healing ,business - Abstract
We present a patient with a cutaneous T-cell lymphoma/mycosis fungoides (CTCL/MF) followed for more than 10 years. After several different aggressive treatments to control progression of CTCL/MF, the patient developed several ulcerated tumors on the abdomen and limbs. Specific systemic antibiotic therapy failed to treat skin infection. While treating the stage III CTCL with polychemotherapy, we used an active colloidal hydrogel topically to manage wound healing and to treat and prevent potential sources of sepsis. After 11 weeks of treatment we observed complete cicatrization of ulcerated tumors. We reported on this case to describe the importance of a correct management of skin ulcers in immunosuppressed patients in order to avoid possible systemic spread of infection which represents the major cause of death in these patients.
- Published
- 2006
48. Comparison of diagnostic methods in the diagnosis of dermatomycoses and onychomycoses
- Author
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Stefano Calvieri, Ugo Bottoni, R.G. Borroni, Vincenzo Panasiti, Valeria Devirgiliis, L. Fabbrizio, Raffaele Masciangelo, and M. Rossi
- Subjects
Pathology ,medicine.medical_specialty ,Diagnostic methods ,business.industry ,Fungi ,dermatomycosis ,fluorescence ,onychomycosis ,Dermatology ,General Medicine ,Dermatomycosis ,Sensitivity and Specificity ,Acridine Orange ,Staining ,Infectious Diseases ,parasitic diseases ,Dermatomycoses ,Humans ,Medicine ,Mycological Typing Techniques ,business ,Azo Compounds ,Fungal material - Abstract
Direct microscopic examination of potassium hydroxide (KOH)-prepared specimens is the simplest, cheapest method used for the diagnosis of mycotic infections of the skin. However, KOH preparations have been reported to have 5-15% of false-negative results, possibly because of the low visibility of scant, scattered fungal material of the nail scrapings and because the detection of fungal elements depends on the skill of the observer [Arch Dermatol133 (1997) 1317; Clin Microbiol Rev8 (1995) 240]. We compared two different KOH-based staining methods in order to obtain reliable results in shorter time than expected for cultures. A total of 124 patients with suspect diagnosis of dermatomycosis or onychomycosis were enrolled. Two scrapings from the same lesion of each patient were stained with KOH-Chlorazole and KOH-Acridine Orange (AO), respectively; cultural examination of the same specimen was considered as diagnostic gold standard. The two methods showed neither significantly different sensitivity nor specificity; however, for onychomycoses, we observed a slightly higher sensitivity for KOH-Chlorazole and a higher specificity for KOH-AO. We suggest the use of both techniques in order to improve detection of fungal infection, especially for onychomycoses.
- Published
- 2006
49. A pigmented acral lesion
- Author
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Stefano Calvieri, Ugo Bottoni, Luigi Laino, Daniele Innocenzi, and Carmen Cantisani
- Subjects
Lesion ,Pathology ,medicine.medical_specialty ,Infectious Diseases ,business.industry ,Medicine ,Dermatology ,medicine.symptom ,business - Published
- 2006
50. Complete remission of brain metastases in three patients with stage IV melanoma treated with BOLD and G-CSF
- Author
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Guido Trasimeni, Vincenzo Panasiti, Rita Clerico, Stefano Calvieri, Ugo Bottoni, R.G. Borroni, P. Bonaccorsi, and Valeria Devirgiliis
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Vincristine ,Skin Neoplasms ,medicine.medical_treatment ,Dacarbazine ,Disease-Free Survival ,Bleomycin ,Lomustine ,Antineoplastic Combined Chemotherapy Protocols ,Granulocyte Colony-Stimulating Factor ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Melanoma ,Aged ,Neoplasm Staging ,Chemotherapy ,Brain Neoplasms ,business.industry ,Remission Induction ,General Medicine ,Middle Aged ,medicine.disease ,Chemotherapy regimen ,Surgery ,Regimen ,Treatment Outcome ,Oncology ,Concomitant ,Female ,business ,Progressive disease ,medicine.drug ,bold ,brain metastases ,g-csf ,melanoma ,polychemotherapy - Abstract
Background Brain metastases are the most life-threatening among the secondary localizations of melanoma for their unresponsiveness to the surgical, radiotherapeutic and/or chemotherapeutic treatments. Methods Accidentally, we observed a complete response (CR) in a patient undergoing chemotherapy with bleomycin, vincristine or Oncovin, CCNU or lomustine, dacarbazine (BOLD) regimen for metastatic melanoma including brain metastases, who was also treated with G-CSF to manage a concomitant leukopenia. After this observation, seven more patients with stage IV melanoma with brain metastases were treated with BOLD regimen repeated every 6 weeks with administration of G-CSF in the intervals. Results Three patients presented CR (37.5%). Two patients stopped the treatment after two courses for evident progressive disease (25%). The other three patients showed stable disease (SD: 37.5%). Median duration of SD was 24 weeks. Among the eight patients, six (75%) achieved clinical benefit. Median time to progression was 8.5 months (range 0-74+ months). Median survival was 12.5 months (range 4-74+ months). Two patients are still alive and disease-free after 74 and 57 months, respectively. Conclusion We believe that the brilliant CR, the long duration of the disease-free intervals and the long survival in at least three of eight patients should encourage further research on BOLD with G-CSF for the treatment of advanced melanoma.
- Published
- 2005
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