30 results on '"Yongfeng Chen"'
Search Results
2. <scp> KIT </scp> ‐related piebaldism in a Chinese girl
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Yu-Qi Huang, Yongfeng Chen, Chao Yang, Lei Zhu, Qi Zhang, Wen-Cong Xu, and Wei Zhong
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Proband ,Sanger sequencing ,Mutation ,medicine.medical_specialty ,business.industry ,Genetic counseling ,Piebaldism ,Prenatal diagnosis ,medicine.disease_cause ,medicine.disease ,Dermatology ,symbols.namesake ,Depigmentation ,Genetics ,symbols ,Medicine ,Family history ,medicine.symptom ,business ,Genetics (clinical) - Abstract
Piebaldism is a rare, autosomal dominant and congenital pigmentary disorder characterized by stable depigmentation of the skin and white forelock. Mutations in KIT or SNAI2 genes result in piebaldism. Most individuals with piebaldism have a family history of the disorder. Herein, we report a 5-month-old Chinese girl with severe piebaldism but no family history thereof. She has white forelock and large patches of depigmentation in the jaw, central anterior trunk, perineum and extremities. We performed whole-exome and Sanger sequencing and identified a de novo KIT mutation (NM_000222.2: c.2657G>A, p.Gly886Val) in exon 18 of KIT in the proband. Currently, this mutation is located in the most extreme C-terminal of the tyrosine kinase domain 2 of the KIT gene amongst all reported mutations and causes a severe clinical phenotype. We further reviewed literature on piebaldism and summarized 79 KIT gene mutations that lead to this disease. Our study may expand knowledge on the genotype-phenotype correlation in piebaldism and serve as a reference for genetic counseling and prenatal diagnosis of affected families.
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- 2020
3. Self-Care Efficacy-Mediated Associations Between Healthcare Provider-Patient Communication and Psychological Distress Among Patients With Gastrointestinal Cancers
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Jinbing Bai, Liyuan Zhang, Jilian Li, Yanrong Chen, and Yongfeng Chen
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Mediation (statistics) ,medicine.medical_specialty ,Oncology (nursing) ,business.industry ,Communication ,Health Personnel ,Psychological intervention ,Psychological distress ,Health Promotion ,Affect (psychology) ,Hospital Anxiety and Depression Scale ,Psychological Distress ,Self Care ,Cross-Sectional Studies ,Oncology ,Health care ,Medicine ,Humans ,Patient communication ,business ,Psychiatry ,Healthcare providers ,Gastrointestinal Neoplasms - Abstract
BACKGROUND Both healthcare provider-patient communication and self-care efficacy affect psychological distress, which is prevalent among patients with gastrointestinal (GI) cancers. It is essential to explore the underlying mechanism among them to relieve psychological distress. OBJECTIVE The aim of this study was to examine whether self-care efficacy mediated the association between healthcare provider-patient communication and psychological distress among patients with GI cancers. METHODS A cross-sectional study was conducted between March 2018 and May 2019 in China. In total, 219 patients with GI cancers were recruited before discharge from chemotherapy. Healthcare provider-patient communication was assessed by the revised Physician-Patient Communication Scale; patient self-care efficacy was assessed by the Strategies Used by People to Promote Health; and psychological distress was assessed by the Distress Thermometer and the Hospital Anxiety and Depression Scale. Mediation analyses were conducted to examine the mediating effect of self-care efficacy on the association between healthcare provider-patient communication and psychological distress. RESULTS A total of 54.34% of patients experienced psychological distress. Patients reported a mean score of 89.93 (SD, 13.81) for healthcare provider-patient communication and 93.91 (SD, 23.39) for self-care efficacy. Self-care efficacy completely mediated the association between healthcare provider-patient communication and psychological distress, and communication outcome was the only domain that significantly influenced self-care efficacy. CONCLUSION Psychological distress is prevalent among patients with GI cancers. Healthcare provider-patient communication, especially communication outcome, promoted patients' self-care efficacy to reduce psychological distress. IMPLICATIONS FOR PRACTICE Healthcare providers should design interventions to improve communication outcomes and eventually increase self-care efficacy to relieve psychological distress among patients with GI cancers.
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- 2021
4. Evaluation of short‐term (16‐week) effectiveness and safety of guselkumab in patients with psoriasis: A prospective real‐life study on the Chinese population
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Yongfeng Chen, Xin-Ze Li, Ze-Qiao Zhang, Jia-Yi Zhuang, Xiao-Hua Wang, Jin-Sheng Li, Hang Su, Yuan-Qiu Zhong, and Fang-Fei Zhang
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China ,medicine.medical_specialty ,Chinese population ,business.industry ,Antibodies, Monoclonal ,FOXP3 ,Dermatology ,General Medicine ,Disease ,Antibodies, Monoclonal, Humanized ,Logistic regression ,medicine.disease ,Severity of Illness Index ,Treatment Outcome ,Guselkumab ,Internal medicine ,Psoriasis ,Humans ,Medicine ,In patient ,Prospective Studies ,business ,Adverse effect - Abstract
Real-life data on guselkumab in psoriasis are limited and not available in China hitherto. This study aimed to evaluate the short-term effectiveness and safety of guselkumab in patients with psoriasis under Chinese real-life conditions and to explore the effect of guselkumab on CD4+ CD25+ Foxp3+ regulatory T cells (Tregs). A Chinese prospective and real-life study involving patients with psoriasis in Dermatology Hospital of Southern Medical University, Guangzhou, China from April to September 2020 was conducted. A total of 45 patients with psoriasis were finally enrolled in the study. Psoriasis Area Severity Index (PASI) 90 and 100 responses at week 16 were achieved by 88.6% and 45.5% of patients, respectively. The analysis of PASI response in different subgroups showed no statistically significant difference. Univariate logistic regression analysis revealed that at week 16, none of the variables were associated with decreasing PASI 90 response, whereas age at onset of disease was a predictor of PASI 100 response. Dynamic detection of CD4+ CD25+ Foxp3+ Tregs frequency from peripheral blood suggested a stable maintained trend in terms of guselkumab treatment duration. No severe adverse events occurred during the follow-up period. This study confirmed the short-term effectiveness and safety of guselkumab, as well as its good tolerance against psoriasis, in the Chinese population. Guselkumab treatment maintains levels of Tregs in patients with psoriasis.
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- 2021
5. Methotrexate-induced toxic epidermal necrolysis in a child undergoing a combination therapy for systemic lupus erythematosus
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Huotao Li, Jiao Zhang, and Yongfeng Chen
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medicine.medical_specialty ,Combination therapy ,business.industry ,Dermatology ,medicine.disease ,Combined Modality Therapy ,Toxic epidermal necrolysis ,Methotrexate ,Infectious Diseases ,Stevens-Johnson Syndrome ,Lupus Erythematosus, Cutaneous ,medicine ,Humans ,Lupus Erythematosus, Systemic ,Child ,business ,medicine.drug - Published
- 2021
6. Phaeohyphomycosis due to Exophiala spinifera greatly improved by ALA-PDT: A case report
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Yangxia Chen, Weiying Zeng, Ruzeng Xue, Jiao Zhang, Hongfang Liu, Yongfeng Chen, and Liyan Xi
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medicine.medical_specialty ,Erythema ,Itraconazole ,medicine.medical_treatment ,Biophysics ,Dermatology ,Exophiala ,medicine ,Adjuvant therapy ,Humans ,Pharmacology (medical) ,Aged, 80 and over ,Photosensitizing Agents ,business.industry ,Aminolevulinic Acid ,medicine.disease ,Phaeohyphomycosis ,Photochemotherapy ,Oncology ,Granuloma ,Terbinafine ,Female ,medicine.symptom ,business ,Adjuvant ,medicine.drug ,Exophiala spinifera - Abstract
An 80-year-old women complained of painful erythema, papules, nodules on her right wrist for 9 months. Granuloma and inflammatory infiltrates with septate fungal hyphae were observed in pathological sections. Growth of demaciatious fungus on SDA was confirmed to be Exophiala spinifera by microscopic appearance and ITS rDNA sequencing. The diagnosis of phaeohyphomycosis due to E. spinifera was established. The patient had a poor response to oral itraconazole (200 mg/d) combining with terbinafine (250 mg/d) for 6 weeks. Then, following three courses of ALA-PDT, used as adjuvant therapy, skin lesions greatly improved and remained stable after 3 months follow-up. The case suggests that ALA-PDT is an effective adjuvant treatment option for patients with recalcitrant local subcutaneous fungal infection.
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- 2019
7. Using the synthesized peptide HAYED (5) to protect the brain against iron catalyzed radical attack in a naturally senescence Kunming mouse model
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Hongdian Wang, Limiao Dai, Shi Bai, Yang Yue, Zou Zhenyou, Shiyi Shen, Chengbo Huang, Yaping Zhou, Cuiping Rong, Yali Xu, Lin Cheng, Fan Yihao, Xiaoying Cheng, Yewen Luo, Derong Fu, Liu Yang, Jue Huang, Lifen Chen, Tan Jie, Shanshan Zhang, Kechun Zou, Jie Chen, Ye Chen, Yuxiang Lu, Zhongmin Wu, Jianxing Zhang, Lijuan Wu, Qiqiong Shen, Xiaotong Zhang, Yukai Lin, Zengxian Wang, Cai Jing, Yongfeng Chen, Li Liangxian, Xin Chen, Xin Li, Aiguo Zhong, Chengliang Zhang, Ying Ye, Hongjie Zheng, Yong Zhou, Yarong Ding, Qiang Zhao, Yingjie Lou, Jiaren Chen, and Baohua Bian
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0301 basic medicine ,Senescence ,Aging ,medicine.medical_specialty ,Iron ,Morris water navigation task ,Inflammation ,Brain damage ,Biochemistry ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Cerebrospinal fluid ,Alzheimer Disease ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,Humans ,Maze Learning ,Neurons ,Kidney ,Amyloid beta-Peptides ,Chemistry ,Brain ,Neurodegenerative Diseases ,Peptide Fragments ,Disease Models, Animal ,Neuroprotective Agents ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,Gene Expression Regulation ,Cell culture ,Neuron ,medicine.symptom ,030217 neurology & neurosurgery - Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disease of the brain. It cannot be cured currently, and those suffering from AD place a great burden on their caregivers and society. AD is characterized by high levels of iron ions in the brain, which catalyze radicals that damage the neurons. Knowing that the Aβ42 peptide precipitates iron by binding iron ions at amino acid residues D1, E3, H11, H13, and H14, we synthesized a 5-repeat (HAYED) sequence peptide. By treating iron-stressed SH-SY5Y cells with it and injecting it into the cerebrospinal fluid (CSF) of naturally senescence Kunming mouse, which displaying AD-similar symptoms such as learning and memory dysfunction, neuron degeneration and high level of iron in brain, we found that HAYED (5) decreased the iron and radical levels in the cell culture medium and in the CSF. Specially, the synthesized peptide prevented cell and brain damage. Furthermore, functional magnetic resonance imaging (fMRI), Morris water maze and passive avoidance tests demonstrated that the peptide ameliorated brain blood-oxygen metabolism and slowed cognitive loss in the experimental senescence mice, and clinical and blood tests showed that HAYED (5) was innoxious to the kidney, the liver and blood and offset the AD-associated inflammation and anemia.
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- 2019
8. D-Dimer as a Prognostic Indicator in Critically Ill Patients Hospitalized With COVID-19 in Leishenshan Hospital, Wuhan, China
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Yongfeng Chen, Kun Li, Linqi Xiao, Gaosong Wu, Xiaoming Xu, Xiaohui Wu, Qian Wu, Meilin Yi, Zeming Liu, Jinpeng Li, and Jincao Chen
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Poor prognosis ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,medicine.drug_class ,Antibiotics ,critically ill patients ,Disease ,030204 cardiovascular system & hematology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Internal medicine ,D-dimer ,medicine ,Pharmacology (medical) ,030212 general & internal medicine ,d-dimer ,Original Research ,Pharmacology ,Critically ill ,business.industry ,lcsh:RM1-950 ,COVID-19 ,Retrospective cohort study ,Intensive care unit ,prognostic indicator ,lcsh:Therapeutics. Pharmacology ,SARS–CoV–2 ,business - Abstract
Background: D-dimer is a small protein fragment and high levels of D-dimer have been associated with increased mortality in patients presenting to emergency departments with infection. Previous studies have reported increased levels of D-dimer in COVID-19; however, it is unclear whether an increased D-dimer level provides early warning of poor prognosis. Therefore, this study aimed to assess the usefulness of D-dimer as an early indicator of prognosis in patients with coronavirus disease (COVID-19).Methods: We conducted a retrospective study of patients with COVID-19 admitted to Leishenshan Hospital in Wuhan, China, from February 15 to March 30, 2020. The final date of follow-up was April 11, 2020.Results: Of the 1,643 patients with COVID-19, 691 had elevated D-dimer levels. Their median age was 65 years. Of the patients with elevated D-dimer levels, 45% had comorbidities, with cardiovascular disease (205 [29.7%]) being the most common. Patients with elevated D-dimer were more likely to require treatment with high-flow oxygen, anticoagulation, antibiotics, and admission to the intensive care unit They were also more likely to have increased interleukin-6, monocytes, and lymphocytes. Patients with elevated D-dimer levels had significantly higher mortality than those with normal or low D-dimer levels.Conclusion: In patients with COVID-19, elevated D-dimer was associated with abnormal immunity, underlying disease, increased disease severity, and increased mortality. Taken together, D-dimer may be a marker for the early warning of disease severity and increased risk of death. These findings provide insights into the potential risk of elevated D-dimer in patients with COVID-19.
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- 2020
9. Improvements in two subtypes of porokeratosis by superficial X‐ray radiotherapy
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Jia-Yi Zhuang, Jiao Zhang, Weijia Wang, Yongfeng Chen, Qing-Wen Li, and Jiarui Liu
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medicine.medical_specialty ,business.industry ,X-Rays ,medicine.medical_treatment ,X-ray ,Dermatology ,General Medicine ,X-Ray Therapy ,medicine.disease ,Porokeratosis ,Radiation therapy ,Humans ,Medicine ,Radiology ,business - Published
- 2020
10. Refractory classic juvenile pityriasis rubra pilaris successfully treated with a combination of etanercept and methotrexate
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Jingyi Li, Yunsheng Liang, Ruzeng Xue, Zemin Zhong, and Yongfeng Chen
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medicine.medical_specialty ,business.industry ,Dermatology ,General Medicine ,medicine.disease ,Etanercept ,Methotrexate ,Refractory ,Pityriasis Rubra Pilaris ,medicine ,Humans ,Juvenile ,Pityriasis rubra pilaris ,business ,Skin ,medicine.drug - Published
- 2020
11. The values of coagulation function in COVID-19 patients
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Yongwei Duan, Yawen Chen, Yuanyuan Li, Shi Mao, Junjuan Gu, Tengfei Bao, Yongfeng Chen, Xin Jin, and Wen Xie
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Adult ,Male ,medicine.medical_specialty ,China ,Science ,Pneumonia, Viral ,030204 cardiovascular system & hematology ,Thrombin time ,Thrombomodulin ,Fibrinogen ,Gastroenterology ,03 medical and health sciences ,Betacoronavirus ,0302 clinical medicine ,Internal medicine ,Coagulopathy ,medicine ,Humans ,Platelet ,Blood Coagulation ,Pandemics ,Blood coagulation test ,Aged ,Prothrombin time ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,SARS-CoV-2 ,COVID-19 ,Blood Coagulation Disorders ,Middle Aged ,medicine.disease ,Coagulation ,030220 oncology & carcinogenesis ,Case-Control Studies ,Medicine ,Female ,Blood Coagulation Tests ,business ,Coronavirus Infections ,Partial thromboplastin time ,medicine.drug ,Research Article - Abstract
ObjectiveTo investigate the blood coagulation function in COVID-19 patients, and the correlation between coagulopathy and disease severity.MethodsWe retrospectively collected 147 clinically diagnosed COVID-19 patients at Wuhan Leishenshan Hospital of Hubei, China. We analyzed the coagulation function in COVID-19 patients through the data including thrombin-antithrombin complex (TAT), α2-plasmininhibitor-plasmin Complex (PIC), thrombomodulin (TM), t-PA/PAI-1 Complex (t-PAIC), prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), D-Dimer (DD), and platelet (PLT).ResultThe levels of TAT, PIC, TM, t-PAIC, PT, INR, FIB, and DD in COVID-19 patients were higher than health controls (pConclusionThe coagulation systems in COVID-19 patients are inordinate, and dynamic monitoring of them, might be a key in the control of COVID-19 death.
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- 2020
12. Clinical features and outcomes of 221 patients with COVID-19 in Wuhan, China
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Yongfeng Chen, Fang Fang, Linjie Luo, Zhiyong Peng, Jianguo Li, Chang Hu, Guqin Zhang, and Huaqin Pan
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medicine.medical_specialty ,Leukopenia ,business.industry ,Mortality rate ,Disease ,medicine.disease ,Single Center ,Procalcitonin ,Pneumonia ,Internal medicine ,Epidemiology ,medicine ,medicine.symptom ,business ,Case series - Abstract
RationaleIn late December 2019, an outbreak of acute respiratory illness, now officially named as COVID-19, or coronavirus disease 2019, emerged in Wuhan, China, now spreading across the whole country and world. More data were needed to understand the clinical characteristics of the disease.ObjectivesTo study the epidemiology, clinical features and outcomes of patients with COVID-19.Methodswe performed a single center, retrospective case series study in 221 patients with laboratory confirmed SARS-CoV-2 pneumonia at a university hospital.Measurements and Main ResultsThe median age was 55.0 years and 48.9% were male and only 8 (3.6%) patients had a history of exposure to the Huanan Seafood Market. Compared to the non-severe pneumonia patients, the median age of the severe patients was significantly older, and they were more likely to have chronic comorbidities. Most common symptoms in severe patients were high fever, anorexia and dyspnea. On admission, 33.0% patients showed leukopenia and 73.8% showed lymphopenia. In addition, the severe patients suffered a higher rate of co-infections with bacteria or fungus and they were more likely to developing complications. As of February 15, 2020, 19.0% patients had been discharged and 5.4% patients died. 80% of severe cases received ICU care, and 52.3% of them transferred to the general wards due to relieved symptoms, and the mortality rate of severe patients in ICU was 20.5%.ConclusionsThe COVID-19 epidemic spreads rapidly by human-to-human transmission. Patients with elder age, chronic comorbidities, blood leukocyte/lymphocyte count, procalcitonin level, co-infection and severe complications might increase the risk of poor clinical outcomes.
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- 2020
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13. Critically Ill Patients with COVID-19 in China: A Multicenter Retrospective Observational Study
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Zhifeng Li, Xingguo Zhang, Xing Liu, Yongfeng Chen, Chang Hu, Shuliang Zhou, Dawei Wang, Chaoyun Jiang, Binbin Wang, Zhiyong Peng, Yimei Yin, Chunxia Chen, and Xiaoyi Zhang
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2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Critically ill ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Outbreak ,Retrospective cohort study ,medicine.disease_cause ,Critical illness ,medicine ,Intensive care medicine ,business ,Coronavirus - Abstract
Background: Since the end of 2019, coronavirus disease-2019 (COVID-19) outbreak spreads around the world We aimed to share the details of critically ill patien
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- 2020
14. Clinical Features and Treatment of 221 Patients with COVID-19 in Wuhan, China
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Chang Hu, Fang Fang, Guqin Zhang, Jian-guo Li, Huaqin Pan, Linjie Luo, Zhiyong Peng, and Yongfeng Chen
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medicine.medical_specialty ,ARDS ,APACHE II ,business.industry ,Mortality rate ,Acute kidney injury ,medicine.disease ,Intensive care unit ,law.invention ,law ,Internal medicine ,Epidemiology ,medicine ,Complication ,business ,Case series - Abstract
Background: In late December 2019, an outbreak of acute respiratory illness, now officially named as COVID-19, or coronavirus disease 2019, emerged in Wuhan, China. We aimed to study the epidemiology and clinical features of patients diagnosed as coronavirus disease 2019 (COVID-19) and their treatment and outcome in Wuhan, China. Methods: We did a single center, retrospective case series study in patients from Zhongnan Hospital of Wuhan University, Wuhan, China. 221 admitted patients with laboratory confirmed SARS-CoV-2 infection, including 55 severe patients and 166 non-severe patients, were recruited from January 2, 2020 to February 10, 2020. Data of epidemiology, clinic, laboratory exams, radiology and treatment were collected from standardized case report forms and compared between the severe and non-severe patients with COVID-19. Specifically, the outcome of corticosteroid therapy was analyzed in the severe patients in intensive care unit (ICU). Findings: Of the 221 patients with COVID-19, 108 (48.9%) of them were male and only 8 (3.6%) patients had a history of exposure to the Huanan Seafood Market. Compared to the non-severe patients, the median age of the severe patients was significantly older (62.0 vs 51.0 years), and they were more likely to have chronic comorbidities, including hypertension, cardiovascular disease and cerebrovascular disease. Most common symptoms in severe patients were high fever, anorexia and dyspnea. On admission, 73 (33.0%) of the 221 patients showed leukopenia and 163 (73.8%) showed lymphopenia. The laboratory results showed more severity of aberrant coagulation pathway, hepatic injury, myocardial injury and kidney injury in the severe patients. In addition, the severe patients suffered a higher rate of co-infections with bacteria or fungus and they were more likely to developing complications, including acute respiratory distress syndrome (ARDS), arrhythmia, acute cardiac injury, shock and acute kidney injury. As of Feb 15, 2020, a total of 42 (19.0%) patients had been discharged and 12 (5.4%) patients died. In the 55 severe patients, 44 (80%) of them received ICU care, and 23 of them transferred to the general wards due to relieved symptoms, and the mortality rate was 21.8%. Interpretation: In this single-center case series of 221 hospitalized patients with confirmed COVID-19 in Wuhan, China, 55 severe patients with elder age and chronic comorbidities, developed more than one complication. The mortality rate was significantly higher in the severe patients compared to that in the non-severe patients (21.8% vs 0.0%). Older and male patients with higher APACHE II & SOFA scores, elevated PCT level, excessive fluid volume input, as well as the delayed use of corticosteroid might increase the risk of death in ICU. Funding Statement: This work was supported by the National Natural Science Foundation of China (grant no. 81700493 to Dr. Pan; grant no. 81971816 to Dr. Peng). Declaration of Interests: The authors declared no conflicts. Ethics Approval Statement: This study was approved by the National Health Commission of China and Ethics Commission of Zhongnan Hospital. Written informed consent was waived by the Ethics Commission for emerging infectious disease.
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- 2020
15. Thin superficial inferior epigastric artery perforator flap for reconstruction of the tongue
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Dong Wang, Tingyi Gao, Tao Xu, Kai Zhang, Shengkai Liao, Yongfeng Chen, and Liang Liu
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Mammaplasty ,Pubic symphysis ,Dissection (medical) ,030230 surgery ,Anastomosis ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Tongue ,medicine ,Humans ,Aged ,medicine.diagnostic_test ,business.industry ,Angiography ,Middle Aged ,medicine.disease ,Epigastric Arteries ,eye diseases ,Surgery ,medicine.anatomical_structure ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Glossectomy ,Abdomen ,Female ,Oral Surgery ,Breast reconstruction ,business ,Perforator Flap - Abstract
The superficial inferior epigastric artery (SIEA) flap is widely used in the repair of large soft tissue defects of the extremities and in breast reconstruction. Because of the high fat content of the abdomen, it has been less used for glossectomy reconstruction. Here we present a series of seven patients who each underwent reconstruction with a thin SIEA flap after resection of the tongue. There were six men and one woman (mean age 48, range 24-66 years). All patients underwent preoperative computed tomographic (CT) angiography, and colour Doppler ultrasound (US) was used to select and map the most suitable SIEA. The flap was raised above the Scarpa's layer while adjusted the plane of dissection according to the specific needs for bulk in each case. All the flaps survived; one flap required a secondary anastomosis because of a venous anastomotic embolus. The size of flap used was 5.0cm×6.0cm - 7.0cm×9.0cm, and the flap was 0.8cm-1.4cm thick. The functional outcome was evaluated at 6 - 18 months follow up, when speech and swallowing were both good in all cases. The dissection above the pubic symphysis is an important refinement of the SIEA flap, and we conclude that the thin SIEA flap is a good choice for reconstruction after excision of cancer of the tongue.
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- 2019
16. Linear orofacial lichen sclerosus
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Jiao Zhang, Ruzeng Xue, Huiqin Pan, Yongfeng Chen, and Eryi Lin
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medicine.medical_specialty ,business.industry ,MEDLINE ,030206 dentistry ,Dermatology ,Lichen sclerosus ,lcsh:RL1-803 ,medicine.disease ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,lcsh:Dermatology ,Medicine ,business - Published
- 2018
17. Symptoms, Hope, Self-Management Behaviors, and Quality of Life Among Chinese Preoperative Patient With Symptomatic Valvular Heart Diseases
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Jing He, Jinbing Bai, Yongfeng Chen, Jing Wei, Guifen Fu, and Fang Liang
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Male ,Pediatrics ,medicine.medical_specialty ,China ,Psychometrics ,Adult population ,Heart Valve Diseases ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Surveys and Questionnaires ,Medicine ,Humans ,030212 general & internal medicine ,General Nursing ,Aged ,Postoperative Care ,Self-management ,business.industry ,Self-Management ,valvular heart disease ,Middle Aged ,medicine.disease ,Quality of Life ,Female ,business - Abstract
Introduction: More than 42 million people are estimated to suffer from valvular heart disease (VHD) worldwide with a prevalence of 5.3% to 7.7% in the Chinese adult population. The purpose of this study was to examine the associations between symptoms, hope, self-management behaviors, and quality of life (QOL) for preoperative patients with symptomatic VHD in a rural area of China. Method: This was a descriptive comparative study that took place in Nanning, China, between January 2015 and March 2016. The sample was 128 preoperative patients with symptomatic VHD. Data were collected using the Symptom Distress Questionnaire, Herth Hope Index, Self-Management Scale, and Minnesota Living with Heart Failure Questionnaire. Results: Data from 122 patients were included in the final analysis. Mean scores of hope, self-management, and QOL were 36.71, 55.27, and 55.56. Worse total scores of symptom severity ( r = 0.57 to 0.69, p < .001) and self-management behaviors ( r = −0.22 to −0.25, p < .05) were associated with poorer QOL. Fatigue, loss of appetite, and self-management behaviors explained 49.90% variance of QOL ( p < .001). Discussion: Fatigue, loss of appetite, and self-management influenced QOL of patients with symptomatic VHD. Interventions aimed at strengthening self-management and relieving symptoms should be tailored for patients with symptomatic VHD base on their traditional animist belief and food culture in rural areas of China such as the Zhuang Autonomous Region.
- Published
- 2019
18. Hydroxychloroquine combined with superficial X‐ray—A new therapeutic method in the treatment of morphea profunda
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Weijia Wang, Yongfeng Chen, Jiao Zhang, and Chao Li
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Adult ,Male ,medicine.medical_specialty ,business.industry ,Standard treatment ,Hydroxychloroquine ,Dermatology ,General Medicine ,X-Ray Therapy ,medicine.disease ,Combined Modality Therapy ,Scleroderma, Localized ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Rare case ,medicine ,Humans ,business ,Morphea ,medicine.drug - Abstract
Morphea profunda (MP) is a variant of morphea that presents clinically as localized fibrotic plaques. Based on previous reports, there was no unified standard treatment for MP. Here we report a rare case of MP, which is the first report about treatment by hydroxychloroquine in combination with superficial X-ray. Compared with other regular therapeutic methods, this method not only produced a positive clinical effect in a short amount of time, but also caused fewer side effects.
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- 2019
19. Combination therapy with afatinib and bevacizumab in an EGFR-mutated non-small cell lung cancer patient with acquired ERBB2 amplification
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Tianmin Xiang, Wei Lu, Qiongyue Zhang, Yuanyuan Li, Zhenzhen Zhang, Yuan Lu, Yongfeng Chen, Gehui Wang, Shuiqiang Hong, Yongguang Cai, Sixian Chen, and Suli Zhou
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Oncology ,medicine.medical_specialty ,Lung Neoplasms ,Combination therapy ,Bevacizumab ,Receptor, ErbB-2 ,Pleural effusion ,Afatinib ,medicine.medical_treatment ,Targeted therapy ,03 medical and health sciences ,Antineoplastic Agents, Immunological ,0302 clinical medicine ,Gefitinib ,Carcinoma, Non-Small-Cell Lung ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,case report ,Humans ,Clinical Case Report ,ERBB2 amplification ,030212 general & internal medicine ,Lung cancer ,non-small cell lung cancer ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,ErbB Receptors ,Drug Resistance, Neoplasm ,030220 oncology & carcinogenesis ,Adenocarcinoma ,Female ,business ,Research Article ,medicine.drug - Abstract
Introduction: Acquired resistance to reversible EGFR tyrosine kinase inhibitors remains a significant obstacle, and acquired ERBB2 amplification is the most common “bypass” mechanism. For patients with sensitizing EGFR mutation who experience resistance via ERBB2 amplification, no targeted drug has been demonstrated to be effective. Patient concerns: A 56-year-old female nonsmoker suffered from left leg paralysis and low back pain. Imaging examination revealed a mass in the anterior segment of the right upper lobe lung and possible multiple metastases in the right hilar, mediastinal lymph nodes, bone metastases, and soft tissue invasion. Diagnosis: Transbronchial lung biopsy revealed a moderately differentiated adenocarcinoma (cT4N2M1c, stage IV). An EGFR exon 19 deletion was identified using amplification refractory mutation system. Interventions: After the patient was treated with gefitinib initiation (250 mg/d) for 15 months, the tumor progressed with ERBB2 amplification revealed by next-generation sequencing test. Then, the patient was started on afatinib (40 mg/d) plus bevacizumab (7.5 mg/kg every 3 weeks). Outcomes: The combination therapy of afatinib and bevacizumab in this patient was effective with some slight side effects. Computed tomography scans showed the tumor shrinkage and the pleural effusion disappeared in the right lung. The overall survival was 23.5 months. Conclusion: To date, there is no targeted therapy approved and demonstrated to be effective for non-small cell lung cancer patients with EGFR sensitizing mutations, and ERBB2 amplification. The effectiveness of combination therapy with afatinib and bevacizumab may provide a new therapeutic option for these patients.
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- 2021
20. Sentinel lymph node biopsy in oral cavity cancer using indocyanine green: A systematic review and meta-analysis
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Yongfeng Chen, Qi Xiao, Weina Zou, Chengwan Xia, Hongling Yin, Yumei Pu, Yuxin Wang, and Kai Zhang
- Subjects
Indocyanine Green ,Medicine (General) ,medicine.medical_specialty ,Sentinel lymph node ,Review Article ,Likelihood ratios in diagnostic testing ,Oral Cavity Cancer ,chemistry.chemical_compound ,R5-920 ,Sensitivity ,medicine ,Humans ,Mouth neoplasm ,Receiver operating characteristic ,Sentinel Lymph Node Biopsy ,business.industry ,Cancer ,General Medicine ,medicine.disease ,chemistry ,Inclusion and exclusion criteria ,Specificity ,Diagnostic odds ratio ,Mouth Neoplasms ,Radiology ,Sentinel Lymph Node ,business ,Indocyanine green - Abstract
This meta-analysis was conducted to evaluate the value of indocyanine green (ICG) in guiding sentinel lymph node biopsy (SLNB) for patients with oral cavity cancer. An electronic database search (PubMed, MEDLINE, Cochrane Library, Embase, and Web of Science) was performed from their inception to June 2020 to retrieve clinical studies of ICG applied to SLNB for oral cavity cancer. Data were extracted from 14 relevant articles (226 patients), and 9 studies (134 patients) were finally included in the meta-analysis according to the inclusion and exclusion criteria. The pooled sentinel lymph node (SLN) sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 88.0% (95% confidence interval [CI], 74.0-96.0), 64.0% (95% CI, 61.0-66.0), 2.45 (95% CI, 1.31-4.60), 0.40 (95% CI, 0.17-0.90), and 7.30 (95% CI, 1.74-30.68), respectively. The area under the summary receiver operating characteristic curve was 0.8805. In conclusion, ICG applied to SLNB can effectively predict the status of regional lymph nodes in oral cavity cancer.
- Published
- 2021
21. Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China
- Author
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Fang Fang, Zhiyong Peng, Huaqin Pan, Yongfeng Chen, Jianguo Li, Chang Hu, Linjie Luo, and Guqin Zhang
- Subjects
Adult ,Male ,0301 basic medicine ,China ,medicine.medical_specialty ,Fever ,Pneumonia, Viral ,030106 microbiology ,Comorbidity ,macromolecular substances ,Article ,Procalcitonin ,law.invention ,Betacoronavirus ,03 medical and health sciences ,0302 clinical medicine ,law ,Virology ,Internal medicine ,Epidemiology ,Humans ,Medicine ,030212 general & internal medicine ,Pandemics ,Aged ,Retrospective Studies ,Coinfection ,SARS-CoV-2 ,business.industry ,Mortality rate ,Age Factors ,COVID-19 ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Intensive care unit ,Anorexia ,Intensive Care Units ,Pneumonia ,Dyspnea ,Infectious Diseases ,Female ,Coronavirus Infections ,business ,Case series - Abstract
Background In late December 2019, an outbreak of acute respiratory illness, coronavirus disease 2019 (COVID-19), emerged in Wuhan, China. We aimed to study the epidemiology, clinical features and short-term outcomes of patients with COVID-19 in Wuhan, China. Methods We performed a single center, retrospective case series study in 221 patients with laboratory confirmed SARS-CoV-2 pneumonia at a university hospital, including 55 severe patients and 166 non-severe patients, from January 2, 2020 to February 10, 2020. Results Of the 221 patients with COVID-19, the median age was 55.0 years and 48.9% were male and only 8 (3.6%) patients had a history of exposure to the Huanan Seafood Market. Compared to the non-severe pneumonia patients, the median age of the severe patients was significantly older, and they were more likely to have chronic comorbidities. Most common symptoms in severe patients were high fever, anorexia and dyspnea. On admission, 33.0% patients showed leukopenia and 73.8% showed lymphopenia. In addition, the severe patients suffered a higher rate of co-infections with bacteria or fungus and they were more likely to developing complications. As of February 15, 2020, 19.0% patients had been discharged and 5.4% patients died. 80% of severe cases received ICU (intensive care unit) care, and 52.3% of them transferred to the general wards due to relieved symptoms, and the mortality rate of severe patients in ICU was 20.5%. Conclusions Patients with elder age, chronic comorbidities, blood leukocyte/lymphocyte count, procalcitonin level, co-infection and severe complications might increase the risk of poor clinical outcomes.
- Published
- 2020
22. Evaluation of the economic burden of leprosy among migrant and resident patients in Guangdong Province, China
- Author
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Mingzhou Xiong, Yongfeng Chen, Ting Su, Daocheng Zheng, Bin Yang, Ming Li, and Xiaohua Wang
- Subjects
Adult ,Male ,medicine.medical_specialty ,China ,Cross-sectional study ,030231 tropical medicine ,Population ,Disease ,Economic burden ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Acquired immunodeficiency syndrome (AIDS) ,Cost of Illness ,Leprosy ,medicine ,Humans ,lcsh:RC109-216 ,030212 general & internal medicine ,education ,Transients and Migrants ,education.field_of_study ,business.industry ,Migrant ,Middle Aged ,medicine.disease ,Medical insurance ,Infectious Diseases ,Cross-Sectional Studies ,Family medicine ,Tropical medicine ,Female ,business ,Research Article - Abstract
Background A lot of time and money was needed during the diagnosis and treatment process of leprosy, the delayed leprosy would also impair the labor capability of patients as well, and these put a heavy burden for the leprosy patients. The migrant leprosy patient is a special group and need more concern. Our goal was to assess the economic burden of leprosy on migrant and resident patient populations in Guangdong province, China. Methods We conducted a population-based cross-sectional survey from February to July of 2016. A self-designed questionnaire was administered to leprosy patients who: (1) had registered in Leprosy Management Information System in China (LEPMIS) by the end of February 2016, (2) had received multiple drug treatment (MDT) drugs at a local leprosy control institution for three consecutive months or had had at least one physical check in the past half year, and (3) were willing to take part in the investigation and give informed written consent. Demographic characteristics, Financial and disease information, and costs before and after leprosy diagnosis were collected and compared using t-test and χ2 test. Results A total of 254 participants completed the questionnaires, including 168 males and 86 females. Migrants and residents accounted for 33.9% and 66.1% of patients, respectively. Among migrant patients, the median cost before diagnosis was $131.6 (39.2–450.9), the median yearly cost of leprosy treatment after diagnosis was $300.6 (158.4–868.5), and the median yearly cost of leprosy complications was $69.5 (11–178.4). In comparison, among residents the median yearly costs were $152.4 (30.7–770.9) pre-diagnosis, $309.7 (103.2–1016.7) after diagnosis, and $91.9 (32.6–303.1) for leprosy complications. Base on this, we determined that the median yearly total expense after diagnosis amounted to 15% of migrant and 38% of resident patients’ annual income. Conclusion Leprosy places a heavy economic burden on both migrant and resident leprosy patients and governmental policies and programs could substantially alleviate this. Measures to implement more active surveillance and early diagnosis would benefit both populations, while labor protection and medical insurance are urgently needed for migrant patients and easier access to medical services and social aids could substantially decrease the burden of leprosy for resident patients.
- Published
- 2017
23. Evaluating the effectiveness of psychological and/or educational interventions in psoriasis: A narrative review
- Author
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Yongfeng Chen, Andy S. K. Cheng, and Tiantian Xin
- Subjects
medicine.medical_specialty ,Weakness ,Cognitive Behavioral Therapy ,business.industry ,Psychological intervention ,Alternative medicine ,Dermatology ,General Medicine ,medicine.disease ,law.invention ,Patient Education as Topic ,Randomized controlled trial ,law ,Psoriasis ,medicine ,Nursing Interventions Classification ,Humans ,Narrative ,Educational interventions ,medicine.symptom ,business ,Clinical psychology - Abstract
The aim of the present study was to review the effectiveness of psychological and/or educational interventions for reducing psoriasis severity and improving psychological and quality of life (QOL) outcomes in psoriasis. Sixteen papers met the inclusion criteria. Overall, the effectiveness of the existing interventions from this narrative synthesis is positive, especially in psychological and QOL outcomes. Of the 16 included studies, only five were randomized controlled trials (RCTs). The strength of the evidence to support the effectiveness of the existing interventions was limited due to methodological weakness in the included studies. The review concludes that further research is needed to examine the effectiveness of psychological and/or educational interventions for individuals with psoriasis, including a greater number of RCTs in order to increase the methodological validity of intervention studies. Also, future research needs to be conducted to establish which interventions are most effective for specific sub-populations who may best profit from psycho-educational interventions.
- Published
- 2014
24. Cutaneous plasmacytosis occurring on the head-face area: a Chinese case
- Author
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Tieqiang Wu, Ruzeng Xue, Yongfeng Chen, Wenjing Chen, Lining Huang, and Huiqing Pan
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Head (linguistics) ,business.industry ,Plasmacytosis ,Biopsy ,medicine ,Dermatology ,medicine.disease ,business - Published
- 2013
25. Effect of an educational intervention on parental readiness for premature infant discharge from the neonatal intensive care units
- Author
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Jinbing Bai, Yongfeng Chen, and Jun Zhang
- Subjects
Adult ,Male ,Parents ,medicine.medical_specialty ,Pediatrics ,Group based ,China ,Care setting ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Child Rearing ,030225 pediatrics ,Intervention (counseling) ,Intensive care ,Health care ,medicine ,Humans ,Young adult ,General Nursing ,030504 nursing ,Child rearing ,Parenting ,business.industry ,Moderate level ,Infant, Newborn ,Middle Aged ,Patient Discharge ,Caregivers ,Family medicine ,Female ,0305 other medical science ,business ,Infant, Premature - Abstract
Aim To examine the effect of an educational intervention on parental readiness for premature infant discharge from neonatal intensive care units. Background Low readiness for discharge can result in negative healthcare outcomes for infants and their parents. However, few studies have examined the effect of discharge education programmes on parental readiness for premature infant discharge in Chinese critical care settings. Design A quasi-experimental study. Methods Between October 2011–March 2012, 154 parents of premature infants were recruited from neonatal intensive care units of two tertiary hospitals in Central China. These parents were assigned to either the intervention or control group based on their entry order. Parents in the intervention group received two sessions of 60-minute discharge education along with hospital routine care; parents in the control group only received hospital routine care. Parental readiness for discharge and quality of discharge education were assessed on the day of infant discharge from neonatal intensive care units. Independent samples t-test and linear regression were used to analyse the data. Results Parental readiness for premature infant discharge was in the moderate level. Independent samples t-test showed that both mean scores of parental discharge readiness and discharge teaching quality from the intervention group were significantly higher than those in the control group. Linear regression analysis showed that discharge teaching quality explained 39·7% of the variance in parental readiness for premature infant discharge. Conclusion Discharge education can improve parental readiness for premature infant discharge. Quality of discharge teaching can significantly predict parental readiness for premature infant discharge.
- Published
- 2015
26. Low-dose methotrexate combined with superficial X-ray in the treatment of folliculotropic mycosis fungoides: A case report
- Author
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Yanan Jiang, Ruzeng Xue, Weijia Wang, and Yongfeng Chen
- Subjects
medicine.medical_specialty ,business.industry ,Treatment outcome ,Dermatology ,lcsh:RL1-803 ,Folliculotropic Mycosis Fungoides ,Low dose methotrexate ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,030220 oncology & carcinogenesis ,lcsh:Dermatology ,Medicine ,business - Published
- 2017
27. Relationship between apparent diffusion coefficient and tumour cellularity in lung cancer
- Author
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Wenwei Wang, Xiao-Chu Yan, Lihua Chen, Yongfeng Chen, Jian Wang, Xiangdong Zhou, and Jiuquan Zhang
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Cytoplasm ,Lung Neoplasms ,lcsh:Medicine ,Adenocarcinoma ,Diagnostic Radiology ,Diffusion ,Diagnostic Medicine ,Biopsy ,medicine ,Medicine and Health Sciences ,Cancer Detection and Diagnosis ,Effective diffusion coefficient ,Humans ,Prospective Studies ,Prospective cohort study ,Lung cancer ,lcsh:Science ,Cell Nucleus ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,Radiology and Imaging ,lcsh:R ,Magnetic resonance imaging ,respiratory system ,Thorax ,medicine.disease ,Small Cell Lung Carcinoma ,body regions ,Diffusion Magnetic Resonance Imaging ,Oncology ,Carcinoma, Squamous Cell ,lcsh:Q ,Female ,business ,Software ,Diffusion MRI ,Research Article - Abstract
BACKGROUND AND OBJECTIVE: To prospectively investigate the relationship between the apparent diffusion coefficient (ADC) and cellularity in lung cancer. METHODS: Sixty patients histopathologically confirmed with lung cancer (41 men, 19 women) underwent diffusion-weighted magnetic resonance imaging of the chest (with b values of 50 and 1000 s/mm2). The median mean ADC (ADC mean) value and median minimum ADC (ADC min) value within each primary tumour were calculated and compared with the median nucleo-cytoplasmic ratio (NCR), which was selected to represent the cellularity. The correlation between the NCR and ADC mean/ADC min was calculated with SPSS 18.0 software. RESULTS: The mean ADC mean values, ADC min values and median NCR were (1.07 ± 0.12) × 10(-3) mm2/s, (0.86 ± 0.14) × 10(-3) mm2/s, and (14.9 ± 2.6) %, respectively, in adenocarcinoma; (0.88 ± 0.10) × 10(-3) mm2/s, (0.73 ± 0.12) × 10(-3)) mm2/s, and (20.6 ± 4.4) %, respectively, in squamous cell carcinoma; and (0.89 ± 0.13) × 10(-3) mm2/s, (0.67 ± 0.13) × 10(-3) mm2/s, and (18.3 ± 3.5) %, respectively in small cell lung cancer. The NCR of squamous cell carcinoma and small cell lung cancer is greater than that of adenocarcinoma (P < 0.01 and P = 0.002, respectively). There was an inverse relationship between ADC mean/NCR and ADC min/NCR (r = -0.60, P = 0.001 and r = -0.47, P < 0.001, respectively). CONCLUSION: There is a significant inverse relationship between tumour cellularity and ADC in lung cancer. However, tumour cellularity most likely is not the sole determinant of the ADC.
- Published
- 2014
28. Tumor Vascularity and Glucose Metabolism Correlated in Adenocarcinoma, but Not in Squamous Cell Carcinoma of the Lung
- Author
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Jiuquan Zhang, Jian Wang, Lin Cheng, Wenwei Wang, Lihua Chen, Xiangdong Zhou, and Yongfeng Chen
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Lung Neoplasms ,Tumor Physiology ,PET imaging ,lcsh:Medicine ,Contrast Media ,Squamous Cell Lung Carcinoma ,Carbohydrate metabolism ,Adenocarcinoma ,Lung and Intrathoracic Tumors ,Diagnostic Radiology ,Computed Tomography ,Carcinoma, Non-Small-Cell Lung ,Basic Cancer Research ,medicine ,Humans ,lcsh:Science ,Multidisciplinary ,Squamous-cell carcinoma of the lung ,Lung ,medicine.diagnostic_test ,business.industry ,lcsh:R ,Cancers and Neoplasms ,Magnetic resonance imaging ,Blood flow ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Non-Small Cell Lung Cancer ,stomatognathic diseases ,medicine.anatomical_structure ,Glucose ,Oncology ,Positron emission tomography ,Positron-Emission Tomography ,Nuclear medicine ,Carcinoma, Squamous Cell ,Medicine ,lcsh:Q ,Female ,business ,Radiology ,Tomography, X-Ray Computed ,Drug metabolism ,Research Article - Abstract
Background/Objectives To prospectively examine the relation between tumor vascularity and glucose metabolism in adenocarcinoma (AC) and squamous cell carcinoma(SCC) of the lung by using positron emission tomography/computed tomography (PET/CT) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Materials and Methods Forty-one consecutive patients with histologically confirmed untreated NSCLC underwent routine diagnostic work-up, including DCE-MRI and PET/CT. PET/CT images were used to derive glucose metabolism (SUVmax and SUVmean), and DCE-MRI images were used to derive tumor vascularity (Ktrans, Kep, Ve and iAUC). Any differences in the DCE-MRI and PET/CT estimations between the NSCLC subtypes were determined by the Wilcoxon rank sum test. Spearman’s rank correlation coefficients were calculated between the DCE-MRI parameter values and the SUV. Results SUVmean and SUVmax in AC were significantly lower than in SCC, but Ktrans and Ve in AC were significantly higher than in SCC. Significant correlations between SUV and DCE-MRI parameters were observed for SUVmax and Ve (ρ = −0.357, P = 0.022), SUVmean and Ktrans (ρ = −0.341, P = 0.029), and SUVmean and iAUC (ρ = −0.374, P = 0.016 ) in total; for SUVmax and iAUC (ρ = −0.420, P = 0.037), SUVmean and Ktrans (ρ = −0.411, P = 0.041), SUVmean and Kep (ρ = −0.045, P = 0.026), and SUVmean and iAUC (ρ = −0.512, P = 0.009) in AC; However, for neither in SCC. Conclusion AC and SCC showed different patterns in both tumor vascularity and glucose metabolism. Tumor vascularity and glucose metabolism negatively correlated in AC, but not in SCC. These differences may underlie the heterogeneity in clinical aspect of NSCLC subtypes and have implications for their imaging profiling and monitor the treatment response.
- Published
- 2014
29. A Case of Cutaneous Blastic Plasmacytoid Dendritic Cell Neoplasm
- Author
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Ruzeng Xue, Youshou Gu, Bin Yang, Tieqiang Wu, Jushi Qiu, Yongfeng Chen, and Huiqing Pan
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Medicine ,Dermatology ,General Medicine ,Blastic plasmacytoid dendritic cell neoplasm ,Dendritic cell ,business - Published
- 2010
30. Retraction
- Author
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Yongfeng Chen, Qing Zhang, Marcia Petrini, Yan-Qiong Ouyang, and You-xian Xu
- Subjects
medicine.medical_specialty ,Nursing ,business.industry ,Family medicine ,Obstetrics and Gynecology ,Medicine ,Breastfeeding knowledge ,business - Abstract
Ouyang,Y, Xu Y, Petrini M, Zhang Q, Chen Y. (2011). Breastfeeding knowledge, attitudes, and behavior of female Chinese physicians in 2009. J Hum Lact. (Original DOI: 10.1177/0890334411411916)
- Published
- 2011
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