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The purpose of this study was to investigate the effects of family-of-origin differentiation, anxiety, and sense of well-being on marital adjustment among married men and women. The Participants of this study were 244 married men and 324 married women, who had preschooler children. The results were as follows: First, family-of-origin differentiation in both men and women had a direct effect on anxiety and sense of well-being. Second, family-of-origin differentiation for both men and women were indirectly influenced by marital adjustment through anxiety and sense of well-being. Third, anxiety of women influenced dyadic consensus at greater degree than men`s. Fourth, anxiety and sense of well-being in both men and women had a direct effect on dyadic consensus, dyadic satisfaction, dyadic cohesion and dyadic affection expression. Finally, in women`s cases, it was indicated that emotional cut-off from mother directly influences marital adjustment.