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1. Factors associated with climacteric symptoms in women around menopause attending menopause clinics in Italy.

Author

Di Donato P, Giulini NA, Bacchi Modena A, Cicchetti G, Comitini G, Gentile G, Cristiani P, Careccia A, Esposito E, Gualdi F, Golinelli S, Bergamini E, Masellis G, Rastelli S, Gigli C, Elia A, Marchesoni D, Sticotti F, Del Frate G, Zompicchiatti C, Marino L, Costa MR, Pinto P, Dodero D, Storace A, Spinelli G, Quaranta S, Bossi CM, Ollago A, Omodei U, Vaccari M, Luerti M, Repetti F, Zandonini G, Raspagliesi F, Dolci F, Gambarino G, De Pasquale B, Polizzotti G, Borsellino G, Alpinelli P, Natale N, Colombo D, Belloni C, Viani A, Cecchini G, Vinci GW, Samaja BA, Pasinetti E, Penotti M, Ognissanti F, Pesando P, Malanetto C, Gallo M, Dolfin G, Tartaglino P, Mossotto D, Pistoni A, Tarani A, Rattazzi PD, Rossaro D, Campanella M, Arisi E, Gamper M, Salvatores D, Bocchin E, Stellin G, Meli G, Azzini V, Tirozzi F, Buoso G, Fraioli R, Marsoni V, Cetera C, Sposetti R, Candiotto E, Sposetti R, Candiotto E, Pignalosa R, Del Pup L, Bellati U, Angeloni C, Buonerba M, Garzarelli S, Santilli C, Mucci M, Di Nisio Q, Cappa F, Pierangeli I, Cordone A, Falasca L, Ferrante D, Cirese E, Todaro PA, Spagnuolo L, Lanzone A, Donadio C, Fabiani M, Baldaccini E, Votano S, Bellardini P, Favale W, Pietrobattista V, Massacesi L, Donini G, Del Savio F, Palombi L, Procaccioli P, Romani A, Romagnoli G, Genazzani AR, Gambacciani M, Scarselli G, Curiel P, De Leo V, Melani A, Levi D'Ancona V, Giarrè G, Di Gioia E, Ceccarelli P, Massi GB, Cosci S, Gacci G, Cascianini A, Donati Sarti C, Bircolotti S, Pupita P, Mincigrucci M, Spadafora A, Santeufemia G, Marongiu G, Lai GR, Lai R, Dessole S, D'Andrea SA, Coppola, Chiantera A, De Placido, Arienzo R, Pastore AR, Tamburrino A, Cardone A, Colacurci N, Izzo S, Tesauro R, Pascarella A, De Silvio MG, Di Prisco L, Lauda N, Sirimarco F, Agrimi C, Casarella G, Senatore G, Ronzini S, Ruccia G, De Carlo G, Pisaturo G, Carlomagno F, Fasolino A, Fiorillo F, Sorrentino R, Ercolano VB, Panariello S, Brun A, Tropea P, Stigliano CM, Amoroso A, Vadalà P, Coco A, Galati G, Barese G, Masciari G, Pirillo P, Gioffrè T, Mastrantonio P, Cardamone A, D'Angelo N, Valentino G, Barretta R, Ferraro G, Ferruccio C, Agostinelli D, Corrado G, Scopelliti A, Schonauer S, Trojano V, Bongiovanni F, Tinelli F, Poddi ER, Scarpello F, Colonna L, Fischetti G, Doria R, Trombetta G, Cocca EB, D'Amore A, Di Masi M, Liguori R, Dimaggio A, Laneve MR, Maolo MC, Gravina G, Nacci G, Nocera F, Lupo A, Giannola C, Graziano R, Mezzatesta M, Vegna G, Giannone G, Palumbo G, Cancellieri F, Mondo A, Cordopatri A, Carrubba M, Mazzola V, Cincotta L, D'Asta S, Bono A, Li Calsi L, Cavallaro Nigro S, Schilirò S, Repici A, Gullo D, Orlando A, Specchiale F, Papotto A, Angeloni, D'Andrea, Stigliano, Arienzo, Di Donato, Giulini, Gigli, Todaro, Marino, Luerti, Donini, Ferrante, Dolfin, Poddi, Santeufemia, Nocera, Melani, Arisi, Mincigrucci, Salvatores, Bocchin, Massacesi A, Chiantera A, De Aloysio P, Omodei U, Ognissanti F, Campagnoli C, Penotti M, Gambacciani A, Graziottin A, Baldi C, Colacurci N, Tonti GC, Parazzini F, Chatenoud L, and Donati Sarti C

Subjects
Adult, Age Factors, Aged, Body Mass Index, Climacteric psychology, Cross-Sectional Studies, Depression epidemiology, Diet, Educational Status, Female, Headache epidemiology, Hot Flashes epidemiology, Humans, Italy epidemiology, Logistic Models, Marital Status, Menopause psychology, Middle Aged, Reproductive History, Smoking, Ambulatory Care Facilities statistics & numerical data, Climacteric physiology, Menopause physiology
Abstract

Objective: To obtain data on correlates of climacteric symptoms in women around menopause attending menopause clinics in Italy., Methods: Since 1997 a large cross sectional study has been conducted on the characteristics of women around menopause attending a network of first level menopause outpatient's clinics in Italy. A total of 66,501 (mean age 54.4 years) women are considered in the present paper., Results: The odds ratios of moderate and severe hot flashes/night sweats were lower in more educated women and (for severe symptoms only) in women reporting regular physical activity. Depression, difficulty to sleep, forgetfulness and irritability tended to be less frequent in more educated women and (depression only) in women reporting regular physical activity. Parous women reported more frequently these symptoms., Conclusions: This large study confirms in Southern European population that low education, body mass index and low physical activity are associated with climacteric symptoms. Parous women are at greater risk of psychological symptoms.

Published
2005
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2. Risk factors for type 2 diabetes in women attending menopause clinics in Italy: a cross-sectional study.

Author

Di Donato P, Giulini NA, Bacchi Modena A, Cicchetti G, Comitini G, Gentile G, Cristiani P, Careccia A, Esposito E, Gualdi F, Golinelli S, Bergamini E, Masellis G, Rastelli S, Gigli C, Elia A, Marchesoni D, Sticotti F, Del Frate G, Zompicchiatti C, Marino L, Costa MR, Pinto P, Dodero D, Storace A, Spinelli G, Quaranta S, Bossi CM, Ollago A, Omodei U, Vaccari M, Luerti M, Repetti F, Zandonini G, Raspagliesi F, Dolci F, Gambarino G, De Pasquale B, Polizzotti G, Borsellino G, Alpinelli P, Natale N, Colombo D, Belloni C, Viani A, Cecchini G, Vinci GW, Samaja BA, Pasinetti E, Penotti M, Ognissanti F, Pesando P, Malanetto C, Gallo M, Dolfin G, Tartaglino P, Mossotto D, Pistoni A, Tarani A, Rattazzi PD, Rossaro D, Campanella M, Arisi E, Gamper M, Salvatores D, Bocchin E, Stellin G, Meli G, Azzini V, Tirozzi F, Buoso G, Fraioli R, Marsoni V, Cetera C, Sposetti R, Candiotto E, Pignalosa R, Del Pup L, Bellati U, Angeloni C, Buonerba M, Garzarelli S, Santilli C, Mucci M, Di Nisio Q, Cappa F, Pierangeli I, Cordone A, Falasca L, Ferrante D, Serra GB, Cirese E, Todaro PA, Romanini C, Spagnuolo L, Lanzone A, Donadio C, Fabiani M, Baldaccini E, Votano S, Bellardini P, Favale W, Monti V, Bonomo A, Boninfante CE, Pietrobattista P, Massacesi L, Donini G, Del Savio F, Palombi L, Procaccioli P, Romani A, Romagnoli G, Genazzani AR, Gambacciani M, Scarselli G, Curiel P, De Leo V, Melani A, Levi D'Ancona V, Giarrè G, Di Gioia E, Ceccarelli P, Massi GB, Cosci S, Gacci G, Cascianini A, Donati Sarti C, Bircolotti S, Pupita P, Mincigrucci M, Spadafora A, Santeufemia G, Marongiu G, Lai GR, Lai R, Dessole S, D'Andrea SA, Coppola, Chiantera A, De Placido, Arienzo R, Pastore AR, Tamburrino A, Cardone A, Colacurci N, Izzo S, Tesauro R, Pascarella A, De Silvio MG, Di Prisco L, Lauda N, Sirimarco F, Agrimi C, Casarella G, Senatore G, Ronzini S, Ruccia G, De Carlo G, Pisaturo G, Carlomagno F, Fasolino A, Fiorillo F, Sorrentino R, Ercolano VB, Panariello S, Brun A, Tropea P, Stigliano CM, Amoroso A, Vadalà P, Coco A, Galati G, Barese G, Masciari G, Pirillo P, Gioffrè T, Mastrantonio P, Cardamone A, D'Angelo N, Valentino G, Barretta R, Ferraro G, Ferruccio C, Agostinelli D, Corrado G, Scopelliti A, Schonauer S, Trojano V, Bongiovanni F, Tinelli F, Poddi ER, Scarpello F, Colonna L, Fischetti G, Doria R, Trombetta G, Cocca EB, D'Amore A, Di Masi M, Liguori R, Dimaggio A, Laneve MR, Maolo MC, Gravina G, Nacci G, Nocera F, Lupo A, Giannola C, Graziano R, Mezzatesta M, Vegna G, Giannone G, Palumbo G, Cancellieri F, Mondo A, Cordopatri A, Carrubba M, Mazzola V, Cincotta L, D'Asta S, Bono A, Li Calsi L, Cavallaro Nigro S, Schilirò S, Repici A, Gullo D, Orlando A, Specchiale F, Papotto A, Abruzzo, Basilicata, Calabria, Campania, Emilia, Romagna, Giulia FV, Lazio, Liguria, Lombardia, Marche, Molise, Piemonte, Puglia, Sardegna, Sicilia, Toscana, Adige TA, Umbria, D'Aosta V, Veneto, Massacesi A, Chiantera A, Donati Sarti C, De Aloysio P, Omodei U, Ognissanti F, Campagnoli C, Penotti M, Gambacciani A, Graziottin A, Baldi C, Colacurci N, Corrado Tonti G, Parazzini F, and Chatenoud L

Subjects
Age Distribution, Ambulatory Care Facilities, Cross-Sectional Studies, Educational Status, Female, Hormone Replacement Therapy, Humans, Italy epidemiology, Middle Aged, Motor Activity, Multivariate Analysis, Obesity epidemiology, Odds Ratio, Risk Factors, Diabetes Mellitus, Type 2 epidemiology, Menopause
Abstract

Objective: To analyze risk factors for type 2 diabetes among women attending menopause clinics in Italy for counselling about the menopause., Subjects: Women attending a network of first-level outpatient menopause clinics in Italy for general counselling about menopause or treatment of menopausal symptoms., Methods: Cross-sectional study with no exclusion criteria. Type 2 diabetes was defined according to National Diabetes Data Groups Indications and the fasting blood glucose at an oral glucose tolerance test within the previous year., Results: Out of the 44 694 considered in this analysis, 808 had a diagnosis of diabetes type 2 (1.8%). In comparison with women aged < 50 years, the multivariate odds ratios (OR) of type 2 diabetes were 1.31 (95% confidence interval (CI), 0.99-1.74) for women aged 50-52 years, 1.66 (95% CI, 1.27-2.17) at 53-56 years and 2.84 (95% CI, 2.20-3.67) in women aged > or = 57 years. Type 2 diabetes was less frequently reported in more educated women (OR high school/university vs. primary school = 0.44 (95% CI, 0.36-0.55)). Being overweight was associated with an increased risk of type 2 diabetes. In comparison with women reporting a low level of physical activity, the multivariate OR of type 2 diabetes was 0.67 (95% CI, 0.54-0.84) for women reporting regular physical activity. In comparison with premenopausal women, the multivariate OR of type 2 diabetes was 1.38 (95% CI, 1.03-1.84) in women with natural menopause. This finding was present also after allowing for the potential confounding effect of age. The multivariate OR of diabetes for users of hormonal replacement therapy was 0.58 (95% CI, 0.46-0.73)., Conclusions: This large cross-sectional study suggests that postmenopausal women are at higher risk of type 2 diabetes after allowance for the effect of age. Other main determinants of risk of type 2 diabetes in women around menopause were low socioeconomic status and being overweight. Diabetes was found less frequently in those taking hormone replacement therapy.

Published
2005
Full Text
View/download PDF

3. Risk factors for type 2 diabetes in women attending menopause clinics in Italy: a cross-sectional study

Author

Di Donato, P, Giulini, N. A, Bacchi Modena, A, Cicchetti, G, Comitini, G, Gentile, G, Cristiani, P, Careccia, A, Esposito, E, Gualdi, F, Golinelli, S, Bergamini, E, Masellis, G, Rastelli, S, Gigli, C, Elia, A, Marchesoni, D, Sticotti, F, Del Frate, G, Zompicchiatti, C, Marino, L, Costa, M. R, Pinto, P, Dodero, D, Storace, A, Spinelli, G, Quaranta, S, Bossi, C. M, Ollago, A, Omodei, U, Vaccari, M, Luerti, M, Repetti, F, Zandonini, G, Raspagliesi, F, Dolci, F, Gambarino, G, De Pasquale, B, Polizzotti, G, Borsellino, G, Alpinelli, P, Natale, N, Colombo, D, Belloni, C, Viani, A, Cecchini, G, Vinci, G. W, Samaja, B. A, Pasinetti, E, Penotti, M, Ognissanti, F, Pesando, P, Malanetto, C, Gallo, M, Dolfin, G, Tartaglino, P, Mossotto, D, Pistoni, A, Tarani, A, Rattazzi, P. D, Rossaro, D, Campanella, M, Arisi, E, Gamper, M, Salvatores, D, Bocchin, E, Stellin, G, Meli, G, Azzini, V, Tirozzi, F, Buoso, G, Fraioli, R, Marsoni, V, Cetera, C, Sposetti, R, Candiotto, E, Pignalosa, R, Del Pup, L, Bellati, U, Angeloni, C, Buonerba, M, Garzarelli, S, Santilli, C, Mucci, M, Di Nisio, Q, Cappa, F, Pierangeli, I, Cordone, A, Falasca, L, Ferrante, D, Serra, G. B, Cirese, E, Todaro, P. A, Romanini, C, Spagnuolo, L, Lanzone, A, Donadio, C, Fabiani, M, Baldaccini, E, Votano, S, Bellardini, P, Favale, W, Monti, V, Bonomo, A, Boninfante, C. E, Pietrobattista, P, Massacesi, L, Donini, G, Del Savio, F, Palombi, L, Procaccioli, P, Romani, A, Romagnoli, G, Genazzani, A. R, Gambacciani, M, Scarselli, G, Curiel, P, De Leo, V, Melani, A, Levi D'Ancona, V, Giarrè, G, Di Gioia, E, Ceccarelli, P, Massi, G. B, Cosci, S, Gacci, G, Cascianini, A, Donati Sarti, C, Bircolotti, S, Pupita, P, Mincigrucci, M, Spadafora, A, Santeufemia, G, Marongiu, G, Lai, G. R, Lai, R, Dessole, S, D'Andrea, S. A, Coppola, Null, Chiantera, A, De Placido, Null, Arienzo, R, Pastore, A. R, Tamburrino, A, Cardone, A, Izzo, S, Tesauro, R, Pascarella, A, De Silvio, M. G, Di Prisco, L, Lauda, N, Sirimarco, F, Agrimi, C, Casarella, G, Senatore, G, Ronzini, S, Ruccia, G, De Carlo, G, Pisaturo, G, Carlomagno, F, Fasolino, A, Fiorillo, F, Sorrentino, R, Ercolano, V. B, Panariello, S, Brun, A, Tropea, P, Stigliano, C. M, Amoroso, A, Vadalà, P, Coco, A, Galati, G, Barese, G, Masciari, G, Pirillo, P, Gioffrè, T, Mastrantonio, P, Cardamone, A, D'Angelo, N, Valentino, G, Barretta, R, Ferraro, G, Ferruccio, C, Agostinelli, D, Corrado, G, Scopelliti, A, Schonauer, S, Trojano, V, Bongiovanni, F, Tinelli, F, Poddi, E. R, Scarpello, F, Colonna, L, Fischetti, G, Doria, R, Trombetta, G, Cocca, E. B, D'Amore, A, Di Masi, M, Liguori, R, Dimaggio, A, Laneve, M. R, Maolo, M. C, Gravina, G, Nacci, G, Nocera, F, Lupo, A, Giannola, C, Graziano, R, Mezzatesta, M, Vegna, G, Giannone, G, Palumbo, G, Cancellieri, F, Mondo, A, Cordopatri, A, Carrubba, M, Mazzola, V, Cincotta, L, D'Asta, S, Bono, A, Li Calsi, L, Cavallaro Nigro, S, Schilirò, S, Repici, A, Gullo, D, Orlando, A, Specchiale, F, Papotto, A, Abruzzo, Null, Basilicata, Null, Calabria, Null, Campania, Null, Emilia, Null, Romagna, Null, Giulia, Friuli Venezia, Lazio, Null, Liguria, Null, Lombardia, Null, Marche, Null, Molise, Null, Piemonte, Null, Puglia, Null, Sardegna, Null, Sicilia, Null, Toscana, Null, Adige, Trentino Alto, Umbria, Null, D'Aosta, Valle, Veneto, Null, Massacesi, A, De Aloysio, P, Campagnoli, C, Gambacciani, A, Graziottin, A, Baldi, C, Colacurci, N, Corrado Tonti, G, Parazzini, F, Chatenoud, L., COLACURCI, Nicola, Di Donato, P, Giulini, N. A, Bacchi Modena, A, Cicchetti, G, Comitini, G, Gentile, G, Cristiani, P, Careccia, A, Esposito, E, Gualdi, F, Golinelli, S, Bergamini, E, Masellis, G, Rastelli, S, Gigli, C, Elia, A, Marchesoni, D, Sticotti, F, Del Frate, G, Zompicchiatti, C, Marino, L, Costa, M. R, Pinto, P, Dodero, D, Storace, A, Spinelli, G, Quaranta, S, Bossi, C. M, Ollago, A, Omodei, U, Vaccari, M, Luerti, M, Repetti, F, Zandonini, G, Raspagliesi, F, Dolci, F, Gambarino, G, De Pasquale, B, Polizzotti, G, Borsellino, G, Alpinelli, P, Natale, N, Colombo, D, Belloni, C, Viani, A, Cecchini, G, Vinci, G. W, Samaja, B. A, Pasinetti, E, Penotti, M, Ognissanti, F, Pesando, P, Malanetto, C, Gallo, M, Dolfin, G, Tartaglino, P, Mossotto, D, Pistoni, A, Tarani, A, Rattazzi, P. D, Rossaro, D, Campanella, M, Arisi, E, Gamper, M, Salvatores, D, Bocchin, E, Stellin, G, Meli, G, Azzini, V, Tirozzi, F, Buoso, G, Fraioli, R, Marsoni, V, Cetera, C, Sposetti, R, Candiotto, E, Pignalosa, R, Del Pup, L, Bellati, U, Angeloni, C, Buonerba, M, Garzarelli, S, Santilli, C, Mucci, M, Di Nisio, Q, Cappa, F, Pierangeli, I, Cordone, A, Falasca, L, Ferrante, D, Serra, G. B, Cirese, E, Todaro, P. A, Romanini, C, Spagnuolo, L, Lanzone, A, Donadio, C, Fabiani, M, Baldaccini, E, Votano, S, Bellardini, P, Favale, W, Monti, V, Bonomo, A, Boninfante, C. E, Pietrobattista, P, Massacesi, L, Donini, G, Del Savio, F, Palombi, L, Procaccioli, P, Romani, A, Romagnoli, G, Genazzani, A. R, Gambacciani, M, Scarselli, G, Curiel, P, De Leo, V, Melani, A, Levi D'Ancona, V, Giarrè, G, Di Gioia, E, Ceccarelli, P, Massi, G. B, Cosci, S, Gacci, G, Cascianini, A, Donati Sarti, C, Bircolotti, S, Pupita, P, Mincigrucci, M, Spadafora, A, Santeufemia, G, Marongiu, G, Lai, G. R, Lai, R, Dessole, S, D'Andrea, S. A, Coppola, Null, Chiantera, A, De Placido, Null, Arienzo, R, Pastore, A. R, Tamburrino, A, Cardone, A, Colacurci, Nicola, Izzo, S, Tesauro, R, Pascarella, A, De Silvio, M. G, Di Prisco, L, Lauda, N, Sirimarco, F, Agrimi, C, Casarella, G, Senatore, G, Ronzini, S, Ruccia, G, De Carlo, G, Pisaturo, G, Carlomagno, F, Fasolino, A, Fiorillo, F, Sorrentino, R, Ercolano, V. B, Panariello, S, Brun, A, Tropea, P, Stigliano, C. M, Amoroso, A, Vadalà, P, Coco, A, Galati, G, Barese, G, Masciari, G, Pirillo, P, Gioffrè, T, Mastrantonio, P, Cardamone, A, D'Angelo, N, Valentino, G, Barretta, R, Ferraro, G, Ferruccio, C, Agostinelli, D, Corrado, G, Scopelliti, A, Schonauer, S, Trojano, V, Bongiovanni, F, Tinelli, F, Poddi, E. R, Scarpello, F, Colonna, L, Fischetti, G, Doria, R, Trombetta, G, Cocca, E. B, D'Amore, A, Di Masi, M, Liguori, R, Dimaggio, A, Laneve, M. R, Maolo, M. C, Gravina, G, Nacci, G, Nocera, F, Lupo, A, Giannola, C, Graziano, R, Mezzatesta, M, Vegna, G, Giannone, G, Palumbo, G, Cancellieri, F, Mondo, A, Cordopatri, A, Carrubba, M, Mazzola, V, Cincotta, L, D'Asta, S, Bono, A, Li Calsi, L, Cavallaro Nigro, S, Schilirò, S, Repici, A, Gullo, D, Orlando, A, Specchiale, F, Papotto, A, Abruzzo, Null, Basilicata, Null, Calabria, Null, Campania, Null, Emilia, Null, Romagna, Null, Giulia, Friuli Venezia, Lazio, Null, Liguria, Null, Lombardia, Null, Marche, Null, Molise, Null, Piemonte, Null, Puglia, Null, Sardegna, Null, Sicilia, Null, Toscana, Null, Adige, Trentino Alto, Umbria, Null, D'Aosta, Valle, Veneto, Null, Massacesi, A, De Aloysio, P, Campagnoli, C, Gambacciani, A, Graziottin, A, Baldi, C, Colacurci, N, Corrado Tonti, G, Parazzini, F, and Chatenoud, L.

Subjects
medicine.medical_specialty, Cross-sectional study, Hormone Replacement Therapy, medicine.medical_treatment, Type 2 diabetes, Motor Activity, Ambulatory Care Facilities, Age Distribution, Risk Factors, Diabetes mellitus, medicine, Odds Ratio, Humans, Obesity, Multivariate Analysi, menopausal status, Gynecology, Cross-Sectional Studie, diabetes, business.industry, Obstetrics, Risk Factor, Obstetrics and Gynecology, Hormone replacement therapy (menopause), General Medicine, Odds ratio, Middle Aged, medicine.disease, Educational Statu, Confidence interval, Menopause, Ambulatory Care Facilitie, women, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Italy, Multivariate Analysis, Educational Status, Female, business, Human
Abstract

To analyze risk factors for type 2 diabetes among women attending menopause clinics in Italy for counselling about the menopause.Women attending a network of first-level outpatient menopause clinics in Italy for general counselling about menopause or treatment of menopausal symptoms.Cross-sectional study with no exclusion criteria. Type 2 diabetes was defined according to National Diabetes Data Groups Indications and the fasting blood glucose at an oral glucose tolerance test within the previous year.Out of the 44 694 considered in this analysis, 808 had a diagnosis of diabetes type 2 (1.8%). In comparison with women aged50 years, the multivariate odds ratios (OR) of type 2 diabetes were 1.31 (95% confidence interval (CI), 0.99-1.74) for women aged 50-52 years, 1.66 (95% CI, 1.27-2.17) at 53-56 years and 2.84 (95% CI, 2.20-3.67) in women agedor = 57 years. Type 2 diabetes was less frequently reported in more educated women (OR high school/university vs. primary school = 0.44 (95% CI, 0.36-0.55)). Being overweight was associated with an increased risk of type 2 diabetes. In comparison with women reporting a low level of physical activity, the multivariate OR of type 2 diabetes was 0.67 (95% CI, 0.54-0.84) for women reporting regular physical activity. In comparison with premenopausal women, the multivariate OR of type 2 diabetes was 1.38 (95% CI, 1.03-1.84) in women with natural menopause. This finding was present also after allowing for the potential confounding effect of age. The multivariate OR of diabetes for users of hormonal replacement therapy was 0.58 (95% CI, 0.46-0.73).This large cross-sectional study suggests that postmenopausal women are at higher risk of type 2 diabetes after allowance for the effect of age. Other main determinants of risk of type 2 diabetes in women around menopause were low socioeconomic status and being overweight. Diabetes was found less frequently in those taking hormone replacement therapy.

Published
2005

4. Factors associated with climacteric symptoms in women around menopause attending menopause clinics in Italy

Author

Parazzini, Fabio, Di Donato, P., Giulini, N. A., Bacchi Modena, A., Cicchetti, G., Comitini, G., Gentile, G., Cristiani, P., Careccia, A., Esposito, E., Gualdi, F., Golinelli, S., Bergamini, E., Masellis, G., Rastelli, S., Gigli, C., Elia, A., Marchesoni, D., Sticotti, F., Del Frate, G., Zompicchiatti, C., Marino, L., Costa, M. R., Pinto, P., Dodero, D., Storace, A., Spinelli, G., Quaranta, S., Bossi, C. M., Ollago, A., Omodei, U., Vaccari, M., Luerti, M., Repetti, F., Zandonini, G., Raspagliesi, F., Dolci, F., Gambarino, G., De Pasquale, B., Polizzotti, G., Borsellino, G., Alpinelli, P., Natale, N., Colombo, D., Belloni, C., Viani, A., Cecchini, G., Vinci, G. W., Samaja, B. A., Pasinetti, E., Penotti, M., Ognissanti, F., Pesando, P., Malanetto, C., Gallo, M., Dolfin, G., Tartaglino, P., Mossotto, D., Pistoni, A., Tarani, A., Rattazzi, P. D., Rossaro, D., Campanella, M., Arisi, E., Gamper, M., Salvatores, D., Bocchin, E., Stellin, G., Meli, G., Azzini, V., Tirozzi, F., Buoso, G., Fraioli, R., Marsoni, V., Cetera, C., Sposetti, R., Candiotto, E., Pignalosa, R., Del Pup, L., Bellati, U., Angeloni, C., Buonerba, M., Garzarelli, S., Santilli, C., Mucci, M., Di Nisio, Q., Cappa, F., Pierangeli, I., Cordone, A., Falasca, L., Ferrante, D., Cirese, E., Todaro, P. A., Spagnuolo, L., Lanzone, A., Donadio, C., Fabiani, M., Baldaccini, E., Votano, S., Bellardini, P., Favale, W., Monti, V., Bonomo, A., Boninfante, C. E., Pietrobattista, P., Massacesi, L., Donini, G., Del Savio, F., Palombi, L., Procaccioli, P., Romani, A., Romagnoli, G., Genazzani, A. R., Gambacciani, M., Scarselli, G., Curiel, P., De Leo, V., Melani, A., Levi D'Ancona, V., Giarrè, G., Di Gioia, E., Ceccarelli, P., Massi, G. B., Cosci, S., Gacci, G., Cascianini, A., Donati Sarti, C., Bircolotti, S., Pupita, P., Mincigrucci, M., Spadafora, A., Santeufemia, G., Marongiu, G., Lai, G. R., Lai, R., Dessole, S., D'Andrea, S. A., Coppola, Null, Chiantera, A., De Placido, Null, Arienzo, R., Pastore, A. R., Tamburrino, A., Cardone, A., Izzo, S., Tesauro, R., Pascarella, A., De Silvio, M. G., Di Prisco, L., Lauda, N., Sirimarco, F., Agrimi, C., Casarella, G., Senatore, G., Ronzini, S., Ruccia, G., De Carlo, G., Pisaturo, G., Carlomagno, F., Fasolino, A., Fiorillo, F., Sorrentino, R., Ercolano, V. B., Panariello, S., Brun, A., Tropea, P., Stigliano, C. M., Amoroso, A., Vadalà, P., Coco, A., Galati, G., Barese, G., Masciari, G., Pirillo, P., Gioffrè, T., Mastrantonio, P., Cardamone, A., D'Angelo, N., Valentino, G., Barretta, R., Ferraro, G., Ferruccio, C., Agostinelli, D., Corrado, G., Scopelliti, A., Schonauer, S., Trojano, V., Bongiovanni, F., Tinelli, F., Poddi, E. R., Scarpello, F., Colonna, L., Fischetti, G., Doria, R., Trombetta, G., Cocca, E. B., D'Amore, A., Di Mas, M., Liguori, R., Dimaggio, A., Laneve, M. R., Maolo, M. C., Gravina, G., Nacci, G., Nocera, F., Lupo, A., Giannola, C., Graziano, R., Mezzatesta, M., Vegna, G., Giannone, G., Palumbo, G., Cancellieri, F., Mondo, A., Cordopatri, A., Carrubba, M., Mazzola, V., Cincotta, L., D'Asta, S., Bono, A., Li Calsi, L., Cavallaro Nigro, S., Schilirò, S., Repici, A., Gullo, D., Orlando, A., Specchial, F., Papotto, A., Abruzzo, Angeloni, Basilicata, D'Andrea, Calabria, Stigliano, Campania, Arienzo, Emilia, Di Donato, Romagna, Giulini, Friuli Venezia Giulia, Gigli, Lazio, Todaro, Liguria, Marino, Lombardia, Luerti, Marche, Donini, Molise, Ferrante, Piemonte, Dolfin, Puglia, Poddi, Sardegna, Santeufemia, Sicilia, Nocera, Toscana, Melani, Trentino Alto Adige, Arisi, Umbria, Mincigrucci, Valle D'Aosta, Salvatores, Veneto, Bocchin, Massacesi, A., De Aloysio, P., Campagnoli, C., Gambacciani, A., Graziottin, A., Baldi, C., Colacurci, N., Corrado Tonti, G., Chatenoud, L., COLACURCI, Nicola, Parazzini, Fabio, Di Donato, P., Giulini, N. A., Bacchi Modena, A., Cicchetti, G., Comitini, G., Gentile, G., Cristiani, P., Careccia, A., Esposito, E., Gualdi, F., Golinelli, S., Bergamini, E., Masellis, G., Rastelli, S., Gigli, C., Elia, A., Marchesoni, D., Sticotti, F., Del Frate, G., Zompicchiatti, C., Marino, L., Costa, M. R., Pinto, P., Dodero, D., Storace, A., Spinelli, G., Quaranta, S., Bossi, C. M., Ollago, A., Omodei, U., Vaccari, M., Luerti, M., Repetti, F., Zandonini, G., Raspagliesi, F., Dolci, F., Gambarino, G., De Pasquale, B., Polizzotti, G., Borsellino, G., Alpinelli, P., Natale, N., Colombo, D., Belloni, C., Viani, A., Cecchini, G., Vinci, G. W., Samaja, B. A., Pasinetti, E., Penotti, M., Ognissanti, F., Pesando, P., Malanetto, C., Gallo, M., Dolfin, G., Tartaglino, P., Mossotto, D., Pistoni, A., Tarani, A., Rattazzi, P. D., Rossaro, D., Campanella, M., Arisi, E., Gamper, M., Salvatores, D., Bocchin, E., Stellin, G., Meli, G., Azzini, V., Tirozzi, F., Buoso, G., Fraioli, R., Marsoni, V., Cetera, C., Sposetti, R., Candiotto, E., Pignalosa, R., Del Pup, L., Bellati, U., Angeloni, C., Buonerba, M., Garzarelli, S., Santilli, C., Mucci, M., Di Nisio, Q., Cappa, F., Pierangeli, I., Cordone, A., Falasca, L., Ferrante, D., Cirese, E., Todaro, P. A., Spagnuolo, L., Lanzone, A., Donadio, C., Fabiani, M., Baldaccini, E., Votano, S., Bellardini, P., Favale, W., Monti, V., Bonomo, A., Boninfante, C. E., Pietrobattista, P., Massacesi, L., Donini, G., Del Savio, F., Palombi, L., Procaccioli, P., Romani, A., Romagnoli, G., Genazzani, A. R., Gambacciani, M., Scarselli, G., Curiel, P., De Leo, V., Melani, A., Levi D'Ancona, V., Giarrè, G., Di Gioia, E., Ceccarelli, P., Massi, G. B., Cosci, S., Gacci, G., Cascianini, A., Donati Sarti, C., Bircolotti, S., Pupita, P., Mincigrucci, M., Spadafora, A., Santeufemia, G., Marongiu, G., Lai, G. R., Lai, R., Dessole, S., D'Andrea, S. A., Coppola, Null, Chiantera, A., De Placido, Null, Arienzo, R., Pastore, A. R., Tamburrino, A., Cardone, A., Colacurci, Nicola, Izzo, S., Tesauro, R., Pascarella, A., De Silvio, M. G., Di Prisco, L., Lauda, N., Sirimarco, F., Agrimi, C., Casarella, G., Senatore, G., Ronzini, S., Ruccia, G., De Carlo, G., Pisaturo, G., Carlomagno, F., Fasolino, A., Fiorillo, F., Sorrentino, R., Ercolano, V. B., Panariello, S., Brun, A., Tropea, P., Stigliano, C. M., Amoroso, A., Vadalà, P., Coco, A., Galati, G., Barese, G., Masciari, G., Pirillo, P., Gioffrè, T., Mastrantonio, P., Cardamone, A., D'Angelo, N., Valentino, G., Barretta, R., Ferraro, G., Ferruccio, C., Agostinelli, D., Corrado, G., Scopelliti, A., Schonauer, S., Trojano, V., Bongiovanni, F., Tinelli, F., Poddi, E. R., Scarpello, F., Colonna, L., Fischetti, G., Doria, R., Trombetta, G., Cocca, E. B., D'Amore, A., Di Mas, M., Liguori, R., Dimaggio, A., Laneve, M. R., Maolo, M. C., Gravina, G., Nacci, G., Nocera, F., Lupo, A., Giannola, C., Graziano, R., Mezzatesta, M., Vegna, G., Giannone, G., Palumbo, G., Cancellieri, F., Mondo, A., Cordopatri, A., Carrubba, M., Mazzola, V., Cincotta, L., D'Asta, S., Bono, A., Li Calsi, L., Cavallaro Nigro, S., Schilirò, S., Repici, A., Gullo, D., Orlando, A., Specchial, F., Papotto, A., Abruzzo, Angeloni, Basilicata, D'Andrea, Calabria, Stigliano, Campania, Arienzo, Emilia, Di Donato, Romagna, Giulini, Friuli Venezia Giulia, Gigli, Lazio, Todaro, Liguria, Marino, Lombardia, Luerti, Marche, Donini, Molise, Ferrante, Piemonte, Dolfin, Puglia, Poddi, Sardegna, Santeufemia, Sicilia, Nocera, Toscana, Melani, Trentino Alto Adige, Arisi, Umbria, Mincigrucci, Valle D'Aosta, Salvatore, Veneto, Bocchin, Massacesi, A., De Aloysio, P., Campagnoli, C., Gambacciani, A., Graziottin, A., Baldi, C., Colacurci, N., Corrado Tonti, G., and Chatenoud, L.

Subjects
Aging, Epidemiology, Cross-sectional study, Marital Statu, Ambulatory Care Facilities, Body Mass Index, Age Factor, Reproductive History, Depression (differential diagnoses), Depression, Smoking, Age Factors, Headache, Obstetrics and Gynecology, Middle Aged, Menopause, Italy, Educational Status, Female, medicine.symptom, Climacteric, Human, Adult, medicine.medical_specialty, Hot Flashe, Logistic Model, Symptom, Irritability, General Biochemistry, Genetics and Molecular Biology, medicine, Humans, Aged, Cross-Sectional Studie, Marital Status, business.industry, Odds ratio, medicine.disease, Educational Statu, Diet, Ambulatory Care Facilitie, Cross-Sectional Studies, Logistic Models, Risk factors, Hot Flashes, Symptoms, Physical therapy, Risk factor, business, Body mass index, Demography
Abstract

OBJECTIVE To obtain data on correlates of climacteric symptoms in women around menopause attending menopause clinics in Italy. METHODS Since 1997 a large cross sectional study has been conducted on the characteristics of women around menopause attending a network of first level menopause outpatient's clinics in Italy. A total of 66,501 (mean age 54.4 years) women are considered in the present paper. RESULTS The odds ratios of moderate and severe hot flashes/night sweats were lower in more educated women and (for severe symptoms only) in women reporting regular physical activity. Depression, difficulty to sleep, forgetfulness and irritability tended to be less frequent in more educated women and (depression only) in women reporting regular physical activity. Parous women reported more frequently these symptoms. CONCLUSIONS This large study confirms in Southern European population that low education, body mass index and low physical activity are associated with climacteric symptoms. Parous women are at greater risk of psychological symptoms.

Published
2005

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