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Objectives: Involving parents and children in mindfulness-based interventions may holistically benefit family well-being. This meta-analysis systematically reviews and synthesizes the effects of mindfulness-based parallel-group (MBPG) interventions, which simultaneously involve parent and child, on family functioning, and the mental health of parents and children. Methods: A total of 20 relevant studies were identified from 14 databases. The overall intervention effect size was estimated by pooled standardized mean difference. Moderator analyses were performed to explain the variability in intervention effects. Risk of bias and publication bias were also assessed. Results: MBPG interventions showed minor-to-small positive effects on family functioning (d = 0.182, 95% CI [0.045, 0.319]), parental mental health (d = 0.238, 95% CI [0.110, 0.365]), and child mental health (d = 0.325, 95% CI [0.137, 0.513]). The effects of MBPG interventions on child mental health varied significantly by child age, child gender, recruitment setting, type of parent group, other activities in child group, other activities in parent group, and study design. Conclusions: MBPG interventions show promising effects in improving mental health of both parents and children as well as in improving overall family functioning. However, significant variations exist in characteristics of participants, interventions, and study designs. Given the limited evidence currently available, more studies are needed to assess the determinants of effectiveness in MBPG interventions. Protocol Registration: PROSPERO #CRD42020164927 [ABSTRACT FROM AUTHOR]

Childhood sexual abuse (CSA) has been shown to predict the coupling of depression and inflammation in adulthood. Trust within intimate relationships, a core element in marital relations, has been shown to predict positive physical and mental health outcomes, but the mediating role of trust in partners in the association between CSA and inflammation in adulthood requires further study. The present study aimed to examine the impact of CSA on inflammatory biomarkers (IL-6 and IL-1β) in adults with depression and the mediating role of trust. A cross-sectional survey data set of adults presenting with mood and sleep disturbance was used in the analysis. CSA demonstrated a significant negative correlation with IL-6 level (r = -0.28, p<0. 01) in adults with clinically significant depression, while trust showed a significant positive correlation with IL-6 level (r = 0.36, p <.01). Sobel test and bootstrapping revealed a significant mediating role for trust between CSA and IL-6 level. CSA and trust in partners were revealed to have significant associations with IL-6 level in adulthood. Counterintuitively, the directions of association were not those expected. Trust played a mediating role between CSA and adulthood levels of IL-6. Plausible explanations for these counterintuitive findings are discussed. [ABSTRACT FROM AUTHOR]